CN105616536A - Traditional Chinese medicine liniment for treating leukoderma - Google Patents
Traditional Chinese medicine liniment for treating leukoderma Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine preparation, and particularly relates to a traditional Chinese medicine liniment for treating leukoderma. The liniment is characterized by being prepared from the following medicinal raw materials in parts by weight: 18-30 parts of tribulus terrestris, 9-18 parts of fructus psoraleae, 8-12 parts of processed polygonum multiflorum, 6-15 parts of angelica sinensis, 2-6 parts of safflower carthamus and 2-10 parts of licorice root. The traditional Chinese medicine liniment has the beneficial effects of dispelling wind, drying dampness, nourishing blood, promoting blood circulation and soothing the liver, can be used for reversing the skin color of a leukoderma affected part and remarkably alleviating extension of the affected area, can cure mild cases and control serious cases, has no allergic response, has toxic or side effect, can be used for a long time since the raw materials are easily available and low in cost, and can be expected to become a necessary medicine for patients with leukoderma.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, namely one treats leukodermic Traditional Chinese medicine liniment.
Background technology
Vitiligo is a kind of chronic, intractable depigmentation dermatoses, it is apt to occur in exposure portion and affects attractive in appearance, it is characterized by that the polytype white patch varying in size, coming in every shape occurs in skin, the generation of skin lesion place melanocyte slows down or disappears, belong to the category of the traditional Chinese medical science " vitiligo is sick ", " leucoderma ", be that one easily diagnoses and dermatosis difficult to treat. Both at home and abroad its research being deepened continuously at present, have pharmacotherapy, physiotherapy and surgical treatment, but how inconspicuous therapeutic effect is, and treatment time is longer, costly, what have also has toxic and side effects. Therefore, finding a kind of evident in efficacy, side effect is little, and raw material is easy to get, the leukodermic medicine for the treatment of with low cost, becomes the target that medical research personnel generally pursue.
Summary of the invention
It is an object of the invention to provide a kind of definite curative effect that vitiligo is had, and raw material is easy to get, with low cost, side effect is little, can the Traditional Chinese medicine liniment of life-time service.
Above-mentioned purpose is realized by techniques below scheme: provide one to treat leukodermic Traditional Chinese medicine liniment, it is characterized in: described Traditional Chinese medicine liniment is made up of crude drug and the solvent of following weight portion: crude drug Fructus Tribuli 18 30 parts, Fructus Psoraleae 9 18 parts, Radix Polygoni Multiflori Preparata 8 12 parts, Radix Angelicae Sinensis 6 15 parts, 26 parts of Flos Carthami, 2 10 parts of Radix Glycyrrhizae, solvent is the alcoholic solution 650 1000 parts of 25% 30%.
Described Traditional Chinese medicine liniment preparation method is: the crude drug of said ratio amount was ground into the fine powder of 100 mesh sieves, Homogeneous phase mixing, loads in vial, adds the solvent of said ratio amount, cover bottle cap sealing, soaking 3, filter to obtain filtrate, residue squeezes to obtain pressed liquor, pressed liquor merges with filtrate, stand 24 hours, take the supernatant, obtain liniment.
Described crude drug adds Radix Sophorae Flavescentis 58 parts, Cortex Phellodendri 46 parts, Fructus Chaenomelis 34 parts.
The preparation method of above-mentioned Traditional Chinese medicine liniment is: by Fructus Tribuli 18 30 parts, Fructus Psoraleae 9 18 parts, Radix Polygoni Multiflori Preparata 8 12 parts, Radix Angelicae Sinensis 6 15 parts, 26 parts of Flos Carthami, 2 10 parts of Radix Glycyrrhizae, Radix Sophorae Flavescentis 58 parts, Cortex Phellodendri 46 parts, Fructus Chaenomelis 34 parts, was ground into the fine powder of 100 mesh sieves, Homogeneous phase mixing, loaded in vial, add the solvent of said ratio amount, cover bottle cap sealing, soak 3, filtering to obtain filtrate, residue squeezes to obtain pressed liquor, and pressed liquor merges with filtrate, stand 24 hours, take the supernatant, obtain liniment.
Described crude drug adds Radix Arnebiae (Radix Lithospermi) 57 parts, Radix Curcumae 36 parts, Radix Et Rhizoma Nardostachyos 25 parts.
The preparation method of above-mentioned Traditional Chinese medicine liniment is: by Fructus Tribuli 18 30 parts, Fructus Psoraleae 9 18 parts, Radix Polygoni Multiflori Preparata 8 12 parts, Radix Angelicae Sinensis 6 15 parts, 26 parts of Flos Carthami, 2 10 parts of Radix Glycyrrhizae, Radix Arnebiae (Radix Lithospermi) 57 parts, Radix Curcumae 36 parts, Radix Et Rhizoma Nardostachyos 25 parts, was ground into the fine powder of 100 mesh sieves, Homogeneous phase mixing, loaded in vial, add the solvent of said ratio amount, cover bottle cap sealing, soak 3, filtering to obtain filtrate, residue squeezes to obtain pressed liquor, and pressed liquor merges with filtrate, stand 24 hours, take the supernatant, obtain liniment.
Described crude drug adds pit 47 parts, Fructus Alpiniae Oxyphyllae 35 parts, Flos Trollii 35 parts.
The preparation method of above-mentioned Traditional Chinese medicine liniment is: by Fructus Tribuli 18 30 parts, Fructus Psoraleae 9 18 parts, Radix Polygoni Multiflori Preparata 8 12 parts, Radix Angelicae Sinensis 6 15 parts, 26 parts of Flos Carthami, 2 10 parts of Radix Glycyrrhizae, pit 47 parts, Fructus Alpiniae Oxyphyllae 35 parts, Flos Trollii 35 parts, was ground into the fine powder of 100 mesh sieves, Homogeneous phase mixing, load in vial, add the solvent of said ratio amount, cover bottle cap sealing, soak 3, filter to obtain filtrate, residue squeezes to obtain pressed liquor, and pressed liquor merges with filtrate, stands 24 hours, take the supernatant, obtain liniment.
The invention has the beneficial effects as follows: by expelling wind and removing dampness, replenishing and activating blood, suppressing the hyperactive liver dispelling wind, vitiligo affected part color reversal can be made, and can substantially slow down the extension suffering from face, mild can heal, and serious symptom is controlled, not yet finds anaphylaxis and toxic and side effects, and raw material is easy to get, with low cost, it is possible to life-time service, it is expected to become the required medicines of patients with vitiligo.
Detailed description of the invention
The present invention is characterized by: Fructus Tribuli, Fructus Psoraleae, Radix Polygoni Multiflori Preparata, Radix Angelicae Sinensis, Flos Carthami, Radix Glycyrrhizae is pulverized and makes liniment, for leukodermic treatment. Embodiment is a lot, below only for four embodiments:
The first embodiment: take Fructus Tribuli 18 30 parts by weight, Fructus Psoraleae 9 18 parts, Radix Polygoni Multiflori Preparata 8 12 parts, Radix Angelicae Sinensis 6 15 parts, 26 parts of Flos Carthami, 2 10 parts of Radix Glycyrrhizae, the alcoholic solution 650 1000 parts of 25% 30%. Preferred Fructus Tribuli 24g, Fructus Psoraleae 13g, Radix Polygoni Multiflori Preparata 10g, Radix Angelicae Sinensis 10 parts of g, Flos Carthami 4g, Radix Glycyrrhizae 6g, and said medicine was ground into the fine powder of 100 mesh sieves, Homogeneous phase mixing, load in vial, add the alcoholic solution 670ml of 25% 30%, cover bottle cap sealing, soak 3, filtering to obtain filtrate, residue squeezes to obtain pressed liquor, and pressed liquor merges with filtrate, stand 24 hours, take the supernatant, obtain liniment.
Using method is: embrocate affected part, 2 times on the one.
Taboo item: during medication, edible raw and cold, greasy, the maror of taboo; Forbid taking orally.
The second embodiment: take Fructus Tribuli 18 30 parts by weight, Fructus Psoraleae 9 18 parts, Radix Polygoni Multiflori Preparata 8 12 parts, Radix Angelicae Sinensis 6 15 parts, 26 parts of Flos Carthami, 2 10 parts of Radix Glycyrrhizae, Radix Sophorae Flavescentis 58 parts, Cortex Phellodendri 46 parts, Fructus Chaenomelis 34 parts, the alcoholic solution 650 1000 parts of 25% 30%. Preferred Fructus Tribuli 24g, Fructus Psoraleae 13g, Radix Polygoni Multiflori Preparata 10g, 10 parts of g of Radix Angelicae Sinensis, Flos Carthami 4g, Radix Glycyrrhizae 6g, Radix Sophorae Flavescentis 6g, Cortex Phellodendri 5g, Fructus Chaenomelis 3.5g, and said medicine was ground into the fine powder of 100 mesh sieves, Homogeneous phase mixing, load in vial, add the alcoholic solution 810ml of 25% 30%, cover bottle cap sealing, soak 3, filtering to obtain filtrate, residue squeezes to obtain pressed liquor, and pressed liquor merges with filtrate, stand 24 hours, take the supernatant, obtain liniment 110g.
Using method is: embrocate affected part, 2 times on the one.
Taboo item: during medication, edible raw and cold, greasy, the maror of taboo; Forbid taking orally.
The third embodiment: take Fructus Tribuli 18 30 parts by weight, Fructus Psoraleae 9 18 parts, Radix Polygoni Multiflori Preparata 8 12 parts, Radix Angelicae Sinensis 6 15 parts, 26 parts of Flos Carthami, 2 10 parts of Radix Glycyrrhizae, Radix Arnebiae (Radix Lithospermi) 57 parts, Radix Curcumae 36 parts, Radix Et Rhizoma Nardostachyos 25 parts, the alcoholic solution 650 1000 parts of 25% 30%. Preferred Fructus Tribuli 24g, Fructus Psoraleae 13g, Radix Polygoni Multiflori Preparata 10g, 10 parts of g of Radix Angelicae Sinensis, Flos Carthami 4g, Radix Glycyrrhizae 6g, Radix Arnebiae (Radix Lithospermi) 6g, Radix Curcumae 4.5g, Radix Et Rhizoma Nardostachyos 3.5g, and said medicine was ground into the fine powder of 100 mesh sieves, Homogeneous phase mixing, load in vial, add the alcoholic solution 810ml of 25% 30%, cover bottle cap sealing, soak 3, filtering to obtain filtrate, residue squeezes to obtain pressed liquor, and pressed liquor merges with filtrate, stand 24 hours, take the supernatant, obtain liniment.
Using method is: embrocate affected part, 2 times on the one.
Taboo item: during medication, edible raw and cold, greasy, the maror of taboo; Forbid taking orally.
4th kind of embodiment: take Fructus Tribuli 18 30 parts, Fructus Psoraleae 9 18 parts, Radix Polygoni Multiflori Preparata 8 12 parts, Radix Angelicae Sinensis 6 15 parts by weight, 26 parts of Flos Carthami, 2 10 parts of Radix Glycyrrhizae, pit 47 parts, Fructus Alpiniae Oxyphyllae 35 parts, Flos Trollii 35 parts, the alcoholic solution 650 1000 parts of 25% 30%. Preferred Fructus Tribuli 24g, Fructus Psoraleae 13g, Radix Polygoni Multiflori Preparata 10g, 10 parts of g of Radix Angelicae Sinensis, Flos Carthami 4g, Radix Glycyrrhizae 6g, pit 6g, Fructus Alpiniae Oxyphyllae 4g, Flos Trollii 4g, and said medicine was ground into the fine powder of 100 mesh sieves, Homogeneous phase mixing, load in vial, add the alcoholic solution 810ml of 25% 30%, cover bottle cap sealing, soak 3, filtering to obtain filtrate, residue squeezes to obtain pressed liquor, and pressed liquor merges with filtrate, stand 24 hours, take the supernatant, obtain liniment.
Using method is: embrocate affected part, 2 times on the one.
Taboo item: during medication, edible raw and cold, greasy, the maror of taboo; Forbid taking orally.
Experimental conditions
1. acute toxicity test:
1.1 Rabbits with Acute toxicity tests: adult healthy white rabbit 24, about body weight 2kg, male and female half and half. Excipient: the alcoholic solution of 25% 30%. Rabbit is randomly divided into 6 groups by body weight, sex, often group 4. Consider vitiligo medication process also exists skin complete and two kinds of situations of skin injury, therefore carried out intact skin experiment and damaged skin two kinds of experiments of experiment. Every kind of experiment divides equally three groups, it may be assumed that high dose group, low dose group and excipient control group. Intact skin tests 24h Na before test2S gelatinized corn starch is by all back part of animal spinal column both sides unhairing. After damaged skin experiment adopts same method unhairing and sterilizes, then with blade, skin is scratched, with oozing of blood for degree. Low dosage is set to 1.25ml/kg, and high dose is set to 5ml/kg, 2 times/d, is applied to depilation district, and surface covers nonirritant gauze, with immobilization with adhesive tape, within second day, removes left drug with warm water.
1.2 overviews: administration is at once to the 7th day, observe systemic toxicity profiles performance and the death condition of animal every day, including skin, hair, eyes, mucosa, extremity activity with or without ANOMALOUS VARIATIONS, observe animal breath, central nervous system shows with or without poisoning symptom simultaneously, and the weight of animals change before and after administration. Experimental result is in Table 1, table 2, table 3.
Table 1 intact skin animal pattern the acute toxicity tests
Table 2 damaged skin animal pattern the acute toxicity tests
Table 3 acute toxicity test rabbit body weight change (kg,)
| Group | Dosage (ml kg) | Before medication | 7d after medication |
| Intact skin | 0 | 2.08��0.13 | 2.28��0.17 |
| Low dose group | 1.25 | 2.05��0.13 | 2.23��0.10 |
| High dose group | 5.00 | 2.03��0.10 | 2.25��0.21 |
| Damaged skin | 0 | 1.98��0.19 | 2.20��0.24 |
| High dose group | 1.25 | 2.08��0.05 | 2.28��0.05 |
| Low dose group | 5.00 | 2.05��0.17 | 2.30��0.22 |
From table 1, table 2, when intact skin and damaged skin animal pattern dosage are up to clinical equivalent amount 40 times, animal is still without dead, observing each treated animal and ANOMALOUS VARIATIONS all do not occur, general activity is normal, and behavior is active, hair light, diet, defecation are without exception, mouth, eye, nose secretions without exception, and mucosa is without hyperemia; From table 3, before and after rabbit administration, body weight is without significant change. Illustrating that this medicine is nontoxic, the clinical application amount of this medicine is the dosage of a safety.
1.3 histopathologic examinations: the observation period terminates, taking each group of Some Animals, to knock head lethal, take medicine area skin and carry out histopathologic examination, result shows, normal group animal skin horny layer, epidermal area and skin corium structural integrity, and damaged skin treated animal is the stratified squamous epithelium of keratinization, it was shown that this liniment high and low dose group, after rabbit medication, skin compares unknown significance difference with matched group.
2. comprehensively analyze:
According to relevant theory of Chinese medical science, leukodermic medicine typing mainly has following three aspects: one, and the heresy of rheumatism is fought in skin, and QI and blood is lost smooth, caused by the not flourish skin of blood; Its two, because feelings will is hindered or because of leucoderma charming appearance and behaviour depressed emotion, liver imbalance is smooth, qi-blood disharmony, caused by failure of skin and muscle to be nourished; Its three, owing to the primary disease persistent period is permanent, prolonged illness damages, and causes caused by caused by liver and kidney deficiency. Based on above-mentioned cognition, through substantial amounts of experiment screening, define this regimen. Prescription is divided into main formula and subsidiary formula two parts, and its main formula can be independently operated, subsidiary formula and can use with main formula combination.
3. the main formula crude drug property of medicine is analyzed:
Fructus Tribuli, derives from the dry mature fruit of zygophyllaceae plant Fructus Tribuli TribulusterrestrisL.. Fatty oil and a small amount of volatile oil, tannin, resin, Alkaloid etc. Nature and flavor are pungent, bitter, and tepor is slightly poisonous, returns Liver Channel. There is suppressing the hyperactive liver dispelling wind, effect of dispelling pathogenic wind for improving eyesight. It is usually used in treatment excessive rising of liver-YANG, has a dizzy spell, wind heat is attacked, cataract, rubella Pruritus. Fructus Tribuli decocting liquid has reduction blood glucose effect; Water extract has anti-allergic effects. According to another report, Fructus Tribuli extract and cream, paraffin, glycerol make external preparation, treatment vulvovaginitis, acne, herpes, varicosis etc., have antiinflammatory, antiviral, antibacterial action (external botanical medicine fascicle, 2001,6:275). The experiment proved that, the Fructus Tribuli tincture of 25% is very micro-to the therapeutic effect of vitiligo disease, and cure rate is less than 2%.
Fructus Psoraleae, derives from the dry mature fruit of legumes psoraleae PsoraleacorylifoliaL.. The property of medicine: acrid, bitter, warm, returns kidney, spleen channel. Containing Coumarins, flavonoid and monoterpene phenols. There is warming the kidney to activate YANG, helping inspiration to relieve asthma, warming spleen and stopping diarrha effect; External pathogenic wind expelling speckle dispelling. For insufficiency of kidney-YANG, impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffer from a deficiency of the kidney and breathe heavily, Diarrhoea. Having pass made, patients with vitiligo is had certain therapeutical effect by the psoralea tincture of 75%, but this tincture sensitization is relatively strong, can produce the untoward reaction such as redness, blister.
Radix Polygoni Multiflori Preparata, for the Preparation process product of Radix Polygoni Multiflori. Mix steaming with Semen sojae atricolor liquor, after solarization, become black, claim Radix Polygoni Multiflori Preparata, its property of medicine: bitter, sweet, puckery, tepor, return liver, kidney channel. There is invigorating the liver and kidney, benefiting essence-blood, crow beard and hair, bone and muscle strengthening, change effect of turbid blood fat reducing. For blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, hyperlipemia is demonstrate,proved. Clinical research in modern age finds, Radix Polygoni Multiflori Preparata and Radix Rehmanniae Preparata, Radix Angelicae Sinensis are dipped in grain neutral spirit and treat poliosis effectively (Shandong journal of Chinese medicine, 1983,4:41).
Flos Carthami, derives from the tubular corolla of feverfew Flos Carthami CarthamustinctoriusL.. Containing carthamone, neocarthamin, Carthamus yellow and flavochrome, separately containing safflower oil. The property of medicine: pungent, warm, GUIXIN, Liver Channel. There is promoting blood circulation to restore menstrual flow, effect of dissipating blood stasis hemostasis. For amenorrhea, dysmenorrhoea, lochia, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, breast side of body twinge, injury from falling down, skin infection swells and ache. According to relevant information: coronary heart diseases and angina pectoris is had by the Flos Carthami injection of 50% controls effect significantly.
Radix Angelicae Sinensis, for the dry root of umbelliferae angelica Angellicasinensis (Oliv.) Diels. Containing neutral oil compositions such as australene, nopinenes, containing to acid-soluble oil composition, organic acid, aminoacid, vitamin etc. such as methylbenzyl alcohol, 5 methoxyl group 2,3 xylenols. The property of medicine: sweet, pungent, warm. Return liver, the heart, spleen channel. There is replenishing and activating blood, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation. Pharmacological action: Radix Angelicae Sinensis volatile oil can the excitation to uterus to antiadrenergic drug pituitrin or histamine. Eumenol has notable expansion isolated guinea pig coronary effect, increases coronary flow. Expeirmental myocardial ischemia is had obvious protective function by Radix Angelicae Sinensis neutral oil. To Mouse oral Radix Angelicae Sinensis infusion, hemoglobin and erythrocytic generation can be remarkably promoted. Clinical research: angelica fluid injects in sensitive spot or neuroganglion, or escalated dose is quiet pushes away or quiet, treatment thromboangiitis obliterans, suffering limb is had pain relieving, blood circulation promoting, improves skin temperature, stop necrosis to occur, develop, the effect such as wound healing (new medicine and pharmacology magazine, 1977,11:35).
Radix Glycyrrhizae, for glycyrrhizic legume GlicyrrhizaualensisFisch., the dry root of Glycyrrhiza inflata Bat. GlicyrrhizainflataBat. Glycyrrhiza glabra L. GlicyrrhizaglabraL. and rhizome. The property of medicine: sweet, flat. GUIXIN, lung, spleen, stomach warp. There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, effect of coordinating the actions of various ingredients in a prescription. It is usually used in weakness of the spleen and stomach, too fat to move sore, relaxes drug toxicity, strong.
Visible, above-mentioned Six-element medicine, Fructus Tribuli is monarch drug, has suppressing the hyperactive liver dispelling wind, effect of expelling wind and removing dampness, for treating the principal agent of leucoderma disease. Fructus Psoraleae, Radix Polygoni Multiflori Preparata return liver, kidney channel, have effect of nourishing the liver and kidney, benefiting essence-blood, and for ministerial drug, meaning has two: one, can assist a ruler in governing a country monarch drug and strengthen treatment vitiligo primary symptom. Its two, if the primary disease persistent period is permanent, prolonged illness damages, and causes caused by liver and kidney deficiency, and Fructus Psoraleae now, Radix Polygoni Multiflori can be held concurrently again treating the liver kidney yin deficient syndrome. Assistant, with Radix Angelicae Sinensis, Flos Carthami, is enriched blood, is invigorated blood circulation, and nourishes skin. Radix Glycyrrhizae QI invigorating and in, coordinating the actions of various ingredients in a prescription, alleviate toxicity, for adjuvant. All medicines share, and play expelling wind and removing dampness, suppressing the hyperactive liver dispelling wind, QI and blood regulating altogether, nourish skin, mediation feelings will, take good care of internal organs, dispel or suppress the merit of white macula.
4. main formula clinical experiment:
With reference to the criterion of therapeutical effect of " clinical disease diagnosis is according to curing improvement standard " (the Sun Chuanxing work People's Medical Officer Press second edition), the concrete curative effect of this liniment is divided into following three grades: cure: skin color recovers normal completely, does not recur; Effective: to have pigment island to be formed in white macula skin lesion, skin color 80% recovers normal, occurs without recurrence and new rash; Take a turn for the better: having pigment island to be formed in white macula skin lesion, skin color 50% recovers normal, occur without recurrence and new rash; Invalid: vitiligo symptom has no to disappear, and white macula is not any change.
Since 2011, in local multiple hospitals, when patient is voluntary, vitiligo disease 70 example betiding different parts is controlled in examination, and medication 15 days is a course for the treatment of, and all three courses for the treatment of of treatment, statistical result is table 1 such as:
Table 1
In above-mentioned 70 example patients with vitiligo, trick portion patient, overall clinical efficacy rate is minimum, and analysis reason is trick face is human body distal portion, and blood circulation is poor, and drug absorption is undesirable and causes, if long-term, intermittent treatment can be adhered to, it is expected to obtain better effect.
5. the subsidiary formula 1 crude drug property of medicine is analyzed:
Radix Sophorae Flavescentis is the dry root of leguminous plant Radix Sophorae Flavescentis SophoraflavescensAit.. Nature and flavor: bitter, cold. GUIXIN, liver, stomach, large intestine, bladder warp. Function with cure mainly: heat clearing and damp drying, parasite killing, diuresis. For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies addiction leprosy; External treatment trichomonal vaginitis.
Cortex Phellodendri is the dry bark of rutaceae wampee PhellodendronchinenseSchneid.. Nature and flavor: bitter, cold. Return kidney, bladder warp. Function with cure mainly: heat clearing and damp drying, pathogenic fire purging except steam, detoxification sore treatment. For damp-heat dysentery, yellow cellulitis dark coloured urine, leukorrhagia pudendal pruritus, the puckery pain of pyretic stranguria, beriberi flaccidity, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema eczema. Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire. For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.
Fructus Chaenomelis is the dry almost ripe fruit of rosaceous plant chaenomeles lagenaria Chaenomelesspeciosa (Sweet) Nakai. Nature and flavor: acid, temperature. Return liver, spleen channel. Function with cure mainly: relaxing muscles and tendons and activating QI and blood in the collateral, stomach function regulating removing dampness. For arthralgia chiefly caused by damp pathogen contracture, waist knee joint acid weight pain, heat-damp in summer is vomited and diarrhoea, and has a cramp spasm and pain, beriberi edema. In modern Application often using Fructus Chaenomelis as anti-acne, Anti-allergic cosmetic raw material.
Visible, above-mentioned three taste medicines, Radix Sophorae Flavescentis, Cortex Phellodendri nature and flavor bitter cold, relatively heat clearing and damp drying, dispels damp, is equipped with acid, the warm nature medicine Fructus Chaenomelis alleviation property of medicine, and can dispel redness, and removing dampness sore alleviates the other medicines sensitivity response to skin. This subsidiary formula 1 is share with main formula, relatively the treatment vitiligo initial stage, and damp invades skin, checks mechanism of qi, caused by the not flourish skin of blood.
6. main formula adds subsidiary formula 1 clinical trial
With reference to the criterion of therapeutical effect of " clinical disease diagnosis is according to curing improvement standard " (the Sun Chuanxing work People's Medical Officer Press second edition), the concrete curative effect of this liniment is divided into following three grades: cure: skin color recovers normal completely, does not recur; Effective: to have pigment island to be formed in white macula skin lesion, skin color 80% recovers normal, occurs without recurrence and new rash; Take a turn for the better: having pigment island to be formed in white macula skin lesion, skin color 50% recovers normal, occur without recurrence and new rash; Invalid: vitiligo symptom has no to disappear, and white macula is not any change.
Since 2012, in local multiple hospitals, when patient is voluntary, extract patient 90 example, wherein course of disease patient 30 example within 3 months, is ill initial stage, the course of disease patient of 3 months to 2 years 28 example, it is ill mid-term, 32 examples of the course of disease more than 2 years, is the ill later stage. Medication 15 days is a course for the treatment of, all three courses for the treatment of of treatment, and its result is added up such as table 2:
Table 2
Upper table data are visible: the overall clinical efficacy rate at initial stage, apparently higher than mid-term, later stage, illustrates that main formula adds subsidiary formula 1 and the initial stage patient that the course of disease is shorter is acted on substantially.
7. the subsidiary formula 2 crude drug property of medicine is analyzed:
Radix Arnebiae (Radix Lithospermi) is comfrey lithospermum euchromum Royle Arnebiaeuchroma (Royle) Johnst. or the dry root of arnebia guttata Bunge Arra coffee aBunge. Nature and flavor: sweet, salty, cold. GUIXIN, Liver Channel. Function with cure mainly: clearing away heat and cooling blood, promoting blood circulation and detoxication, rash speckle removing. Containing for heat in blood poison, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.
Radix Curcumae is the dried root of zingiberaceous plant RADIX CURCUMAE CurcumazvenyujinY.H_ChenetC.Ling, Rhizoma Curcumae Longae CurcumalongaL., Guangxi art CurcumakwangsiensisS.G.LeeetC.F.Liang or Rhizoma Curcumae CurcumaphaeocauLisVal.. Nature and flavor: pungent, bitter, cold. The heart, Liver Channel. Function with cure mainly: promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, clear away heart-fire removing heat from blood, promoting the function of the gallbladder to alleviate jaundice. Coercing twinge for breast, obstruction of qi in the chest and cardialgia, amenorrhea dysmenorrhea, distending pain of the breast, calentura coma, epilepsy is gone mad, and heat in blood tells nosebleed, jaundice dark coloured urine.
Radix Et Rhizoma Nardostachyos is the dry root and rhizome of Valerianaceae plant Radix Et Rhizoma Nardostachyos NardostachysjatamansiDC.. Nature and flavor: acrid, sweet, warm. Return spleen, stomach warp. Function: regulating QI to relieve pain, relieving stagnation and activating the spleen, external damp eliminating is subsided a swelling. For distension and fullness in the abdomen, inappetence, vomiting; Toothache, beriberi toxic swelling are controlled in external.
Visible, above-mentioned three taste medicines, Radix Arnebiae (Radix Lithospermi) enters the heart, Liver Channel, clearing away heat and cooling blood, promoting blood circulation and detoxication, Radix Curcumae master enters the heart, Liver Channel, promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, it is equipped with Radix Et Rhizoma Nardostachyos damp eliminating detumescence, alleviating the other medicines sensitivity response to skin, this subsidiary formula 2 is share with main formula, relatively treatment vitiligo mid-term, depressed emotion, liver imbalance is smooth, qi-blood disharmony, caused by failure of skin and muscle to be nourished.
8. main formula adds subsidiary formula 2 clinical trial
With reference to the criterion of therapeutical effect of " clinical disease diagnosis is according to curing improvement standard " (the Sun Chuanxing work People's Medical Officer Press second edition), the concrete curative effect of this liniment is divided into following three grades: cure: skin color recovers normal completely, does not recur; Effective: to have pigment island to be formed in white macula skin lesion, skin color 80% recovers normal, occurs without recurrence and new rash; Take a turn for the better: having pigment island to be formed in white macula skin lesion, skin color 50% recovers normal, occur without recurrence and new rash; Invalid: vitiligo symptom has no to disappear, and white macula is not any change.
Since 2013, in local multiple hospitals, when patient is voluntary, extract patient 92 example, wherein course of disease patient 32 example within 3 months, is ill initial stage, the course of disease patient of 3 months to 2 years 30 example, it is ill mid-term, 30 examples of the course of disease more than 2 years, is the ill later stage. Medication 15 days is a course for the treatment of, all three courses for the treatment of of treatment, and its result is added up such as table 3:
Table 3
Upper table data are visible: the overall clinical efficacy rate in mid-term apparently higher than initial stage, later stage, illustrates that main formula adds subsidiary formula 2 and course of disease patient in mid-term between 3 months to 2 years is acted on substantially.
9. the subsidiary formula 3 crude drug property of medicine is analyzed:
Pit mongolian medicine name awns accuses day Ji wood this " errorless mongolian medicine mirror ", and different name Ah bar comes, " errorless mongolian medicine mirror " is come in Sabah. Pit for Anacardiaceae plant fruit MangiferaindicaL.. Fruit contains myrcene, fruit keto acid, gallic acid, Quercetin, vitamin C, glucose etc. The property of medicine: sour in the mouth, sweet, warm in nature. Effect is heavy, greasy, returns kidney channel. Function cures mainly: the kidney invigorating, renal cold of dispelling. Cure mainly and suffer from a deficiency of the kidney, renal cold, lumbago and skelalgia.
Fructus Alpiniae Oxyphyllae is the dry mature fruit of zingiberaceous plant Fructus Alpiniae Oxyphyllae. Nature and flavor: pungent, temperature. Return spleen, kidney channel. Function with cure mainly: warming the kidney controlling nocturnal emission with astringent drugs reducing urination, warming spleen and stopping diarrha take the photograph saliva. For enuresis due to deficiency of the kidney, frequent micturition, nebulousurine of passing out semen, spleen-cold syndrome is had loose bowels, cold type of pain in abdomen, the many salivas of mouth.
My Tan Qiqige, not Dege Si Qin of Flos Trollii mongolian medicine name, my smooth Flos Nelumbinis, pentahapto Xi Laqiqige. Dried floral for ranunculaceae plant Flos Trollii TrolliuschinensisBunge. Nature and flavor: bitter in the mouth, cold in nature, blunt, light, soft. There are heat clearing away, dry pus, convergence, effect of Perishing prevention.
Visible, above-mentioned three taste medicines, pit nature and flavor are sour, warm, and Fructus Alpiniae Oxyphyllae nature and flavor are pungent, warm, all enter kidney channel, synergism, temperature compensation kidney, are equipped with Flos Trollii heat clearing away, dry pus, convergence, Perishing prevention, alleviate the other medicines sensitivity response to skin. This subsidiary formula 3 is share with main formula, relatively the treatment vitiligo later stage, and owing to the primary disease persistent period is permanent, prolonged illness damages, and causes caused by caused by liver and kidney deficiency.
10. main formula adds subsidiary formula 3 clinical trial
With reference to the criterion of therapeutical effect of " clinical disease diagnosis is according to curing improvement standard " (the Sun Chuanxing work People's Medical Officer Press second edition), the concrete curative effect of this liniment is divided into following three grades: cure: skin color recovers normal completely, does not recur; Effective: to have pigment island to be formed in white macula skin lesion, skin color 80% recovers normal, occurs without recurrence and new rash; Take a turn for the better: having pigment island to be formed in white macula skin lesion, skin color 50% recovers normal, occur without recurrence and new rash; Invalid: vitiligo symptom has no to disappear, and white macula is not any change.
Since 2014, in local multiple hospitals, when patient is voluntary, extract patient 95 example, wherein course of disease patient 32 example within 3 months, is ill initial stage, the course of disease patient of 3 months to 2 years 32 example, it is ill mid-term, 31 examples of the course of disease more than 2 years, is the ill later stage. Medication 15 days is a course for the treatment of, all three courses for the treatment of of treatment, and its result is added up such as table 4:
Table 4
Upper table data are visible: the overall clinical efficacy rate in later stage, apparently higher than initial stage, mid-term, illustrates that main formula adds subsidiary formula 3 and the later stage patient that the course of disease is longer is acted on substantially.
Claims (8)
1. treat leukodermic Traditional Chinese medicine liniment for one kind, it is characterised in that: described Traditional Chinese medicine liniment is made up of the crude drug of following weight portion: Fructus Tribuli 18 30 parts, Fructus Psoraleae 9 18 parts, Radix Polygoni Multiflori Preparata 8 12 parts, Radix Angelicae Sinensis 6 15 parts, 26 parts of Flos Carthami, 2 10 parts of Radix Glycyrrhizae.
2. the leukodermic Traditional Chinese medicine liniment for the treatment of according to claim 1, it is characterised in that: described Traditional Chinese medicine liniment preparation method is: the crude drug of said ratio amount was ground into the fine powder of 100 mesh sieves, Homogeneous phase mixing, load in vial, add the alcoholic solution that crude drug volume 10 times amount, concentration are 25% 30%, cover bottle cap sealing, soak 3, filter to obtain filtrate, residue squeezes to obtain pressed liquor, and pressed liquor merges with filtrate, stands 24 hours, take the supernatant, obtain liniment.
3. the leukodermic Traditional Chinese medicine liniment for the treatment of according to claim 1, it is characterised in that: described crude drug adds Radix Sophorae Flavescentis 58 parts, Cortex Phellodendri 46 parts, Fructus Chaenomelis 34 parts.
4. the leukodermic Traditional Chinese medicine liniment for the treatment of according to claim 3, it is characterized in that: the preparation method of above-mentioned Traditional Chinese medicine liniment is: by Fructus Tribuli 18 30 parts, Fructus Psoraleae 9 18 parts, Radix Polygoni Multiflori Preparata 8 12 parts, Radix Angelicae Sinensis 6 15 parts, 26 parts of Flos Carthami, 2 10 parts of Radix Glycyrrhizae, Radix Sophorae Flavescentis 58 parts, Cortex Phellodendri 46 parts, Fructus Chaenomelis 34 parts, it was ground into the fine powder of 100 mesh sieves, Homogeneous phase mixing, load in vial, add said medicine volume 10 times amount, concentration is the alcoholic solution of 25% 30%, cover bottle cap sealing, soak 3, filter to obtain filtrate, residue squeezes to obtain pressed liquor, pressed liquor merges with filtrate, stand 24 hours, take the supernatant, obtain liniment.
5. the leukodermic Traditional Chinese medicine liniment for the treatment of according to claim 1, it is characterised in that: described crude drug adds Radix Arnebiae (Radix Lithospermi) 57 parts, Radix Curcumae 36 parts, Radix Et Rhizoma Nardostachyos 25 parts.
6. the leukodermic Traditional Chinese medicine liniment for the treatment of according to claim 5, it is characterized in that: the preparation method of above-mentioned Traditional Chinese medicine liniment is: by Fructus Tribuli 18 30 parts, Fructus Psoraleae 9 18 parts, Radix Polygoni Multiflori Preparata 8 12 parts, Radix Angelicae Sinensis 6 15 parts, 26 parts of Flos Carthami, 2 10 parts of Radix Glycyrrhizae, Radix Arnebiae (Radix Lithospermi) 57 parts, Radix Curcumae 36 parts, Radix Et Rhizoma Nardostachyos 25 parts, it was ground into the fine powder of 100 mesh sieves, Homogeneous phase mixing, load in vial, add said medicine volume 10 times amount, concentration is the alcoholic solution of 25% 30%, cover bottle cap sealing, soak 3, filter to obtain filtrate, residue squeezes to obtain pressed liquor, pressed liquor merges with filtrate, stand 24 hours, take the supernatant, obtain liniment.
7. the leukodermic Traditional Chinese medicine liniment for the treatment of according to claim 1, it is characterised in that: described crude drug adds pit 47 parts, Fructus Alpiniae Oxyphyllae 35 parts, Flos Trollii 35 parts.
8. the leukodermic Traditional Chinese medicine liniment for the treatment of according to claim 7, it is characterized in that: the preparation method of above-mentioned Traditional Chinese medicine liniment is: by Fructus Tribuli 18 30 parts, Fructus Psoraleae 9 18 parts, Radix Polygoni Multiflori Preparata 8 12 parts, Radix Angelicae Sinensis 6 15 parts, 26 parts of Flos Carthami, 2 10 parts of Radix Glycyrrhizae, pit 47 parts, Fructus Alpiniae Oxyphyllae 35 parts, Flos Trollii 35 parts, it was ground into the fine powder of 100 mesh sieves, Homogeneous phase mixing, load in vial, add said medicine volume 10 times amount, concentration is the alcoholic solution of 25% 30%, cover bottle cap sealing, soak 3, filter to obtain filtrate, residue squeezes to obtain pressed liquor, pressed liquor merges with filtrate, stand 24 hours, take the supernatant, obtain liniment.
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Application publication date: 20160601 |