CN108704678A - The T-type micro flow control chip device that Morse code generates - Google Patents

The T-type micro flow control chip device that Morse code generates Download PDF

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Publication number
CN108704678A
CN108704678A CN201810420350.1A CN201810420350A CN108704678A CN 108704678 A CN108704678 A CN 108704678A CN 201810420350 A CN201810420350 A CN 201810420350A CN 108704678 A CN108704678 A CN 108704678A
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China
Prior art keywords
laser
main channel
morse code
phase fluid
type micro
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Pending
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CN201810420350.1A
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Chinese (zh)
Inventor
杨帆
邵旭升
王亚隆
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University of Shanghai for Science and Technology
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University of Shanghai for Science and Technology
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Priority to CN201810420350.1A priority Critical patent/CN108704678A/en
Publication of CN108704678A publication Critical patent/CN108704678A/en
Pending legal-status Critical Current

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/1023Microstructural devices for non-optical measurement
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/026Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N2015/1029Particle size
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N2015/103Particle shape

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Micromachines (AREA)

Abstract

The present invention relates to the T-type micro flow control chip devices that a kind of Morse code generates, the microchannel main channel front of T-type micro-fluidic chip is equipped with continuous phase fluid feeder connection, tail portion is exported equipped with microchannel, the microchannel subchannel of T-type micro-fluidic chip is equipped with the feeder connection of dispersed phase fluid, laser emitter and laser pickoff are equipped at the tail portion of main channel, by controlling the flow next life growth drop and short drop for dispersed phase fluid inject from the feeder connection of dispersed phase fluid, and show in the main channel of microchannel the form of Morse code;Laser emitter projects laser beam and passes through main channel, and when the length drop that length differs being made to pass through main channel, the pulse signal for exporting laser intensity is received by laser pickoff, and the Morse code signal representated by it is transmitted with this.The present invention can generate specific Morse code signal by microlayer model, so that the transmission of the Morse code newly obtained is visualized, it is easier to realize accurate delivery and the control of information.

Description

The T-type micro flow control chip device that Morse code generates
Technical field
The present invention relates to a kind of micro flow control chip device, especially a kind of drop by controlling different length in main channel Spacing is combined into Morse code to realize the device of information transmission.
Background technology
Microflow control technique and micro-fluidic chip are the multi-crossed disciplines fields rapidly developed in recent years, in biology, are changed Credit analysis, information processing etc. are widely used.The method for preparing miniature droplets at present mainly has using spray nozzle device and makes With two kinds of microfluidic device, micro-fluidic chip equipment preparation principle is as follows:
Two kinds of immiscible liquid(Ru Shui and oil)Since the effect of surface tension can form boundary when being in contact.It will be respectively The immiscible continuous phase and dispersed phase flowed in different channels is driven by pressure or volume, makes two kinds of fluids in channel Intersection contacts, the shearing to dispersed phase or squeezing action due to continuous phase so that surface tension is not enough to maintain interface stability And be broken, and then generate dispersed phase drop.
The device of drop is generated by external impetus compared to nozzle etc., micro flow control chip device only needs to control two phase flow The flow-rate ratio of body, the physical property factors such as stickiness generate the length of drop and generate frequency, it can be achieved that essence to drop size to control Quasi- control.
Morse code is in radio signal transmission, the fields extensive applications such as electronic information is transmitted.By between point, cross It combines to achieve the purpose that information is transmitted.In the present invention ruler for generating drop is controlled by controlling the inlet flow rate of two-phase fluid It is very little, to form the drop similar to " point " and " cross " in microchannel, forms different Morse codes and transmitted to reach information Purpose.
Invention content
The present invention is to provide for a kind of T-type micro flow control chip device that Morse code generates, and control T-type micro-fluidic chip generates The different drop of length comes analogy and " point " and " cross " in Morse code, passes through the change of " point " drop and " cross " drop in microchannel Combination is changed, different Morse codes is generated, and is converted into corresponding Maitong signal by the laser sensor of channel tail portion, to reach The purpose transmitted to signal
To achieve the above object, the technical scheme is that:A kind of T-type micro flow control chip device that Morse code generates, including T Type micro-fluidic chip, laser emitter, laser pickoff, the microchannel main channel front of the T-type micro-fluidic chip, which is equipped with, to be connected Continuous phase fluid feeder connection, tail portion are exported equipped with microchannel, and the microchannel subchannel of T-type micro-fluidic chip is equipped with dispersed phase fluid Feeder connection, laser emitter and laser pickoff are equipped at the tail portion of main channel, by control from the channel of dispersed phase fluid The flow next life growth drop of the dispersed phase fluid of entrance injection and short drop, and show Morse code in the main channel of microchannel Form;The laser emitter projects laser beam and passes through main channel, when the length drop that length differs being made to pass through main channel, The pulse signal of output laser intensity receives by laser pickoff, and the Morse code signal representated by it is transmitted with this.
It is mixed into extinction material in the continuous phase fluid of the main channel injection of the T-type micro-fluidic chip, makes mixed company Continuous phase liquid significantly weakens the intensity for taking in laser beam, and the dispersed phase fluid of subchannel injection is single component liquid, no Influence the penetrability of laser beam.
The beneficial effects of the invention are as follows:Control T-type micro-fluidic chip generates the different drop of length and comes analogy and Morse code In " point " and " cross ", combined with the transformation of " cross " drop by " point " drop in microchannel, generate different Morse codes, and lead to The laser sensor of channel tail portion is crossed to be converted into corresponding Maitong signal, to achieve the purpose that signal transmits.Compared to the former, The device can generate specific Morse code signal by microlayer model, so that the transmission of the Morse code newly obtained is visualized, it is easier to real The accurate delivery of existing information and control.
Description of the drawings
Fig. 1 is the T-type micro flow control chip device schematic diagram that Morse code generates;
Fig. 2 is Morse code pulse image.
Specific implementation mode
The invention will be further described with embodiment below in conjunction with the accompanying drawings.
As shown in Figure 1, the present invention Morse code generate T-type micro flow control chip device, including T-type micro-fluidic chip, swash Optical transmitting set 5, laser pickoff 6.The microchannel main channel front of T-type micro-fluidic chip is equipped with continuous phase fluid feeder connection 1, Tail portion is equipped with microchannel and exports 7, and the microchannel subchannel of T-type micro-fluidic chip is equipped with the feeder connection 2 of dispersed phase fluid, main logical Laser emitter 5 and laser pickoff 6 are equipped at road tail portion, point injected from the feeder connection 2 of dispersed phase fluid by control The flow next life growth drop and short drop of dephasing fluid, and show in the main channel of microchannel the form of Morse code;Laser Transmitter 5 projects laser beam and exports laser intensity when the length drop that length differs being made to pass through main channel across main channel Pulse signal is received by laser pickoff 6, and the Morse code signal representated by it is transmitted with this.Wherein, the long drop 3 of generation is used Represent the "-" in Morse code, the short drop 4 of generation is used for indicating " " in Morse code.
It is mixed into extinction material in the continuous phase fluid 2 of the main channel injection of T-type micro-fluidic chip, makes mixed continuous phase Liquid significantly weakens the intensity for taking in laser beam, and the dispersed phase fluid of subchannel injection is single component liquid, is not influenced The penetrability of laser beam.
Now the equipment Morse code transmittance process is illustrated:It is mixed into extinction material in continuous phase liquid, after making mixing Continuous phase liquid to the intensity of taking in laser beam, to have significant weakening, dispersed phase be single component liquid, do not influence laser and penetrate The penetrability of line.Continuous phase liquid is injected from continuous phase fluid feeder connection 1, dispersion fluid self-dispersing phase fluid leads to It is injected at road entrance 2, the length drop as shown in long drop 3 and short drop 4 can be generated by adjusting the flow of continuous phase, due to even Continuous weakening of the phase liquid to laser beam intensity, when the drop that size differs wears the laser beam of the transmitting of enough laser emitters 5 When, can receive the duration in laser pickoff 6 differs and the laser of varying strength, laser intensity letter after treatment It number can show Morse code pulse image as shown in Figure 2, achieve the purpose that transmit information with this.Such as the arteries and veins shown in Fig. 2 The Morse code for rushing graphical representation is " --- ", and the meaning indicated is English alphabet " X ".

Claims (2)

1. the T-type micro flow control chip device that a kind of Morse code generates, including T-type micro-fluidic chip, laser emitter, laser pick-off The microchannel main channel front of device, the T-type micro-fluidic chip is equipped with continuous phase fluid feeder connection, and tail portion goes out equipped with microchannel Mouthful, the microchannel subchannel of T-type micro-fluidic chip is equipped with the feeder connection of dispersed phase fluid, and being equipped with laser at the tail portion of main channel sends out Emitter and laser pickoff, the flow next life by controlling the dispersed phase fluid injected from the feeder connection of dispersed phase fluid grow up Drop and short drop, and show in the main channel of microchannel the form of Morse code;The laser emitter projects laser beam The pulse signal of laser intensity is exported by laser pick-off when the length drop that length differs being made to pass through main channel across main channel Device receives, and the Morse code signal representated by it is transmitted with this.
2. the T-type micro flow control chip device that Morse code according to claim 1 generates, it is characterised in that:The T-type miniflow It is mixed into extinction material in the continuous phase fluid of the main channel injection of control chip, mixed continuous phase liquid is made to penetrate intake laser The intensity of line significantly weakens, and the dispersed phase fluid of subchannel injection is single component liquid, does not influence the penetrability of laser beam.
CN201810420350.1A 2018-05-04 2018-05-04 The T-type micro flow control chip device that Morse code generates Pending CN108704678A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115193498A (en) * 2022-07-26 2022-10-18 之江实验室 Ceramic micro-fluidic chip and preparation method and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101842159A (en) * 2007-08-09 2010-09-22 赛路拉公司 The method and apparatus that related multi-parameter single cell measurements and remnant biological material reclaim
US20100297448A1 (en) * 2005-09-13 2010-11-25 True Randall J Miniaturized microparticles
CN106589412A (en) * 2016-11-28 2017-04-26 华南理工大学 Preparation method for polymer microgel based on microfluidic technology
CN106807463A (en) * 2017-01-22 2017-06-09 北京大学 Micro-fluidic chip and apply its microlayer model generation device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100297448A1 (en) * 2005-09-13 2010-11-25 True Randall J Miniaturized microparticles
CN101842159A (en) * 2007-08-09 2010-09-22 赛路拉公司 The method and apparatus that related multi-parameter single cell measurements and remnant biological material reclaim
CN106589412A (en) * 2016-11-28 2017-04-26 华南理工大学 Preparation method for polymer microgel based on microfluidic technology
CN106807463A (en) * 2017-01-22 2017-06-09 北京大学 Micro-fluidic chip and apply its microlayer model generation device

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115193498A (en) * 2022-07-26 2022-10-18 之江实验室 Ceramic micro-fluidic chip and preparation method and application thereof
CN115193498B (en) * 2022-07-26 2024-04-16 之江实验室 Ceramic micro-fluidic chip and preparation method and application thereof

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Application publication date: 20181026