CN108404040A - The application of drug containing Turmeric P.E and preparation method thereof and Turmeric P.E in preparing the drug for treatment of arthritis - Google Patents
The application of drug containing Turmeric P.E and preparation method thereof and Turmeric P.E in preparing the drug for treatment of arthritis Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/732—Chaenomeles, e.g. flowering quince
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
The present invention relates to the application of a kind of drug containing Turmeric P.E and preparation method thereof and Turmeric P.E in preparing the drug for treatment of arthritis.The drug containing Turmeric P.E is formulated by the raw material of following parts by weight:The turmeric of 30 70 parts by weight, the mustard seed of 10 30 parts by weight, the pawpaw of 10 30 parts by weight, the cassia twig of 5 20 parts by weight, the ramulus mori of 5 20 parts by weight and 5 20 parts by weight pepper.Drug according to the present invention is particularly effective in the treatment of the osteoarthritis and rheumatoid arthritis that are not resistant to the patient of long-term treatment of NSAIDs or steroid.
Description
Technical field
The present invention relates to a kind of drugs containing Turmeric P.E and preparation method thereof and Turmeric P.E to be used in preparation
Application in the drug for the treatment of of arthritis more particularly to it is a kind of for mitigate arthritis and pain containing Turmeric P.E
The application of drug and preparation method thereof and Turmeric P.E in preparing the drug for treatment of arthritis, belongs to the field of Chinese medicines.
Background technology
Arthritis (arthritis), which refers to, is happened at human synovial and its surrounding tissue, by inflammation, infection, degeneration, wound
Or inflammatory disease caused by other factors, tens of kinds can be divided into.The World Health Organization (WHO) arthritis is referred to as " not dead cancer
Disease ".About 1.2 hundred million people of China is undergo the torment of osteoarthritis, the far super cardiovascular and cerebrovascular disease of incidence, China 50 years old with
Half suffers from osteoarthritis in upper crowd, and 90% women and 80% male suffer from osteoarthritis in over-65s crowd.The illness in China
Rate is 0.34%~0.36%, and severe patient's service life about shortens 10~15 years.
From the point of view of pathological research, osteoarthritis is a kind of articular cartilage degeneration, the superfluous chronic regression formed of subchondral bone
Property disease, arthralgia and limitation of activity are its common symptons.The degeneration of osteoarthritis chondrocytes is due to a series of machine
Caused by the collective effects such as tool factor, inflammatory mediator, biochemical factors, especially matrix metalloproteinase and active oxygen.It is closed in bone
It saves in scorching pathology and progress, main reactive oxygen species are nitric oxide, peroxynitric acid salt, superoxide anion.Joint
Scorching clinical manifestation is the red, swollen, hot of joint, pain, dysfunction and joint deformity, and severe patient leads to joint deformity, influences patient
Quality of life.Meanwhile the course of disease is longer, and it is touching refractory, joint deformity, the forfeiture of tetanic and function are easily caused, disability rate is higher, therefore right
Its research treated is one of medicine hot spot now.Chornic arthritis with regard to its clinical characters, belong to motherland's medicine " severe and migratory arthralgia ",
" gout ", " bi Zheng " scope, because its normal recurrent exerbation, prognosis are bad, therefore the maintenance for treating the later stage is very crucial.
Currently, modern medicine there is no radical cure method, this chronic disease to annoying patients always, make chornic arthritis
It is lived, work is all severely impacted.The conventional therapy of osteoarthritis is related to the symptomatic treatment with antalgesic, and with non-steroid
The treatment of body anti-inflammatory drug, the treatment is known to generate serious side effects, which often causes treatment to interrupt.Similar examines
Worry is also applied for rheumatoid arthritis.Due to described, research also common concern is in plant treatment drug and natural plant
Object therapy.
Invention content
The present invention relates to a kind of drug and its preparation method and application containing Turmeric P.E contains turmeric extraction
Object, papaya extractives, Ramulus Cinnamomi extract, Semen Brassicae Junceae extract, extract of mulberry twig and Fructus Piperis extract.Drug is formed by can be used for
The locally and systemically treatment of arthralgia and surface and depth inflammation and antalgesic.Drug according to the present invention be not resistant to
By the osteoarthritis and rheumatoid arthritis (rheumatoid of the patient of the long-term treatment of NSAIDs or steroid
Arthritis it is particularly effective in treatment).
The object of the invention, which also resides in, provides a kind of drug containing Turmeric P.E mitigating arthritis and pain.
The present invention is achieved through the following technical solutions.
The technical solution adopted by the present invention is as follows:
One aspect of the present invention provide a kind of drug containing Turmeric P.E prepared by the raw material of following parts by weight and
At:The turmeric of 30-70 parts by weight, the mustard seed of 10-30 parts by weight, the pawpaw of 10-30 parts by weight, 5-20 parts by weight cassia twig, 5-
The pepper of the ramulus mori and 5-20 parts by weight of 20 parts by weight.
Further, the drug containing Turmeric P.E is formulated by the raw material of following parts by weight:50 weight
Part turmeric, the mustard seed of 15 parts by weight, the cassia twig of 15 parts by weight, the pawpaw of 10 parts by weight, 5 parts by weight ramulus mori and 5 parts by weight
Pepper.
Another aspect of the present invention provides a kind of preparation method of said medicine and includes the following steps:
Weigh respectively in parts by weight the turmeric of 30-70 parts by weight, the mustard seed of 10-30 parts by weight, 10-30 parts by weight wood
Melon, the cassia twig of 5-20 parts by weight, the ramulus mori of 5-20 parts by weight and 5-20 parts by weight pepper as raw material for standby, by the raw material
Extraction obtains Turmeric P.E, Semen Brassicae Junceae extract, papaya extractives, Ramulus Cinnamomi extract, ramulus mori according to a conventional method respectively after crushing
Extract and Fructus Piperis extract, then to the Turmeric P.E, the Semen Brassicae Junceae extract, the papaya extractives, the cassia twig
Extract, the extract of mulberry twig and the Fructus Piperis extract are added pharmaceutically acceptable auxiliary material and are made pharmaceutically acceptable
Meaning dosage form.
Wherein, the amount that the pharmaceutically acceptable auxiliary material is added is adjusted correspondingly according to the dosage form of drug.
Further, water extraction or alcohol extracting are carried out after the raw material being crushed, and after extraction, successively merge extracting solution, mistake
Medicinal extract is filtered and is concentrated under reduced pressure to give, gained medicinal extract is spray-dried to be made corresponding extract.
Further, water extraction is first carried out after the raw material being crushed, after extraction, extracting solution is successively merged, filters and subtract
Pressure is concentrated to give the first medicinal extract, and first medicinal extract is carried out alcohol extracting again, after extraction, extracting solution is successively merged, filters and subtract
Pressure is concentrated to give the second medicinal extract, and the second medicinal extract of gained is spray-dried to be made corresponding extract.
Further, alcohol extracting is first carried out after the raw material being crushed, after extraction, extracting solution is successively merged, filters and subtract
Pressure is concentrated to give the first medicinal extract, and first medicinal extract is carried out water extraction again, after extraction, extracting solution is successively merged, filters and subtract
Pressure is concentrated to give the second medicinal extract, and the second medicinal extract of gained is spray-dried to be made corresponding extract.
Wherein, the inlet air temperature of the spray drying is 170-180 DEG C, and the leaving air temp of the spray drying is 70-
80℃。
Further, the water, which extracts, includes:The 10-30 times of water measured of the raw material weight after addition crushes every time, and in
It is extracted 1-4 times at 80 DEG C~100 DEG C, every time extraction 1-3 hours.
Further, the alcohol extracting includes:The 4-15 times of containing alcohol capacity measured of the raw material weight after crushing is added every time
It for the ethyl alcohol of 30-80wt%, extracts 1-4 times, every time extraction 1-3 hours.
Further, the pharmaceutically acceptable auxiliary material includes one kind in disintegrant, lubricant, adhesive and filler
Or it is several:The disintegrant includes but not limited to cornstarch, sodium carboxymethyl starch;The lubricant includes but not limited to tristearin
Sour magnesium, polyethylene glycol, superfine silica gel powder (such as silica);Described adhesive includes but not limited to maltodextrin, microcrystalline cellulose
Element;And the filler includes but not limited to lactose, mannitol, sucrose;The drug is oral preparation, the oral preparation
Dosage form is decoction, syrup, pill, tablet, capsule, pill or granule.
The present invention also provides a kind of application of Turmeric P.E in preparing the drug for treatment of arthritis.
Specific implementation mode
Pathogenesis in relation to rheumatoid arthritis RA (Rheumatoid Arthritis), although not yet completely bright at present
Really, but recent years studies have shown that osteoarthritis is due to a series of mechanical factor, inflammatory mediator, biochemical factors, especially
It is caused by the collective effects such as matrix metalloproteinase and active oxygen.In the pathology and progress of osteoarthritis, main activity
Oxygen species are nitric oxide, peroxynitric acid salt, superoxide anion.These factors are not only to participate in having for articular chondrocyte apoptosis
Noxious material, and be the important signaling molecule of cell metabolism.It is clear that curcumin has proved to be a kind of effectively active oxygen in vitro
Except agent and active nitrogen provide agent.Inhibit neutrophil cell and the relevant enzyme of inflammation such as matrix metalloproteinase 9 by curcumin
Antioxidation is realized in activation, or the synthesis of enhancing glutathione, this is the mechanism of curcumin treatment of arthritis.Reach slow
Pain is solved, the purpose for improving joint mobility and improving the quality of living.
Curcumin is the native compound found in spice turmeric, belongs to polyphenols, is a kind of low molecule polyphenol
Close object.Ayurveda (Ayurvedic) medicine has had the history in several centuries using turmeric extract for treating disease.In conventional medicament
The purposes includes the treatment of indigestion, flatulence and diarrhea, and the inflammatory disorders especially after long-term treatment and
The treatment of arthralgia.Many conventional uses are confirmed by external biological chemical test or pharmacology.
With modern medicine curcumin is studied it is increasingly deep, find curcumin have extensive physiological activity, have
Anti-inflammatory, it is anti-oxidant, free radical is removed, the effects that anticancer, cardiovascular protection.(Di Jianbin, Gu Zhenlun, Zhao Xiaodong, Qian Peigang,
Jiang little Gang, anti-oxidant and Research progress in anti-inflammatory effects [J] Chinese herbal medicines .2010.41 (5) of Guo time instrument curcumin:Attached 18-21.
Luo Tingshun, Li Hongwen, Liu Zhengwen wait extraction separation and Advance on Pharmacological Activities [J] the modern medicines and clinic of curcumins,
2011,26(2):102-107.).Studies have found that curcumin (Curcumin) can effectively treat arthritis and osteoarthritis
Caused pain inhibits arthritic disease hair, reinforces the pliability of body.The Tucson vitamin K1 research center of Arizona State
A Human clinical study, it was also found that curcumin can efficiently reduce knee joint swelling and inflammation.(Funk, L., et
al.Turmeric extracts containing curcuminoids prevent experimental rheumatoid
arthritis.Journal of Natural Products.69(3):351-355,2006.).Curcumin has as one kind
Representative plant origin drug has apparent anti-inflammatory antioxidation and no stomach and intestine relative to nonsteroidal and-inflammatory drug
The adverse reactions such as road, this illustrates that it is likely to become the substitute of point steroidal anti-inflammatory medicines.(Zhang Rui, the clear curcumins protection of Liu's generation
Articular cartilage inhibits effect and mechanism [J] the China Tissue Engineering Study of osteoarthritis, 2015,19 (2):277-282.)
Simultaneously inhibitor of the curcumin as Nuclear factor κB kB, can protect mescenchymal stem cell from proinflammatory disease because
The damage of son helps to stimulate cartilage in vitro to create stable microenvironment for the Subchondral drilling of mescenchymal stem cell
Regeneration establishes experiment basis for treatment osteoarthritis in next step.And the pipering use in conjunction in Fructus Piperis extract can carry significantly
Bioavilability when curcumin is used alone in height, shortens the time for reaching maximum plasma concentration.
Pawpaw is that the drying of rosaceous plant chaenomeles lagenaria Chaenomeles speciosa (Sweet) Nakai is closely ripe
Fruit.It is sour, it is warm-natured.There is the effect of relaxing tendons and activating collaterals, stomach dampness elimination.For treating arthritis with fixed pain caused by dampness contraction, waist and knee joint acid weight pain, heat
Wet vomiting and diarrhoea, convulsion contraction pain, tinea pedis oedema.
Cassia twig acrid, sweet, warm enter lung, the heart, bladder warp.Zhenyang, degrading the channel, eliminating cold to stop pain can be helped.Cassia twig is that have in Chinese medicine
Representative drug is one of most common drug of Chinese medicine rheumatism.Can " the gas use for helping the whole body ", with " gas " five big work(
Can, and the reconciliation thought of Chinese medicine " causing to neutralize " is embodied, compatibility is carried out with the cassia twig with harmonizing nutrient QI and difensive QI, warming meridian,
Achieve the purpose that treat Bi condition, especially early stage RA cassia twig and its class can in and Rong Wei, transferring negative and positive.Modern medicine
Reason research confirms have anti-inflammatory and antalgic with rheumatism immunological diseases such as cassia twig compatibility combination side treatment rheumatoid arthritis, inhibit to promote
Inflammatory cytokine, parahormone sample activity, or even have certain prevention destruction of joint, delay the effect of disease progression.
Mustard seed is warm-natured, acrid flavour.There is the work(of moistening lung for removing phlegm, swelling and pain relieving, warming spleen and stomach for dispelling cold, the sharp aquation stasis of blood, degrading the channel, poison of subsiding a swelling
Effect, cures mainly the diseases such as gastrofrigid vomiting, trusted subordinate's pain, lung cold cough, rheumatism, larynx numbness, the tuberculosis of bone and joint, traumatic injury.《Compendium of Materia Medica》It says:
" mustard seed warming spleen and stomach for dispelling cold, the clear pain that dissipates swell ".The pungent row of mustard seed, Wen Tong have removing toxicity for detumescence, relax through dredging collateral, the work(of promoting blood circulation to remove blood stasis.In recent years
Show that semen brassicae alcohol extracting thing can obviously inhibit the increase of mouse capillary permeability for the pharmacological research of semen brassicae, prolongs
The long pain reaction time, to have the function that anti-inflammatory and antalgic.
Ramulus mori mildly bitter flavor, mild-natured, return liver warp have the effect of wind-damp dispelling, sharp joint, are used for Bi condition, shoulder arm, joint
Ache numbness.《Pharmacopoeia of People's Republic of China》(version in 2010):Ramulus mori has the effect of wind-damp dispelling, sharp joint.For rheumatism
Numbness disease, shoulder arm, joint pain are numb.
Pepper is the nearly ripe or ripening fruits of drying of Piperaceae plant pepper, pungent, heat.Return stomach, large intestine channel, there is middle benefit gas to dissipate
It is cold, the effect of lower gas, dissolving phlegm.It is antitumor, anti-insane that modern medicine study shows that the main pharmacodynamics ingredient pipering of pepper has
Epilepsy, antidepression, it is anti-oxidant, promote drug metabolism the effects that.Pipering can improve general naphthalene Lip river as bioavilability reinforcing agent
The bioavilability in vivo such as that, choline theophyllinate, curcumin;
The drug of the present invention has the advantages that:
The present invention is to provide the drugs for mitigating arthritis and pain, by Turmeric P.E, papaya extractives, osmanthus
Branch extract, Semen Brassicae Junceae extract, extract of mulberry twig and Fructus Piperis extract are compounded in specific proportions.
The effect of pawpaw, cassia twig in formula, mustard seed, ramulus mori all have dispelling wind and eliminating dampness, arthritis eliminating cold to stop pain is middle treatment
Treat the common drug of rheumatoid arthritis.To expelling wind and removing dampness, remove obstruction in channels to relieve pain, mass dissipating and swelling eliminating the effect of.Studies have shown that semen brassicae
In mustard seed alcohol extracting thing can obviously inhibit the increase of mouse capillary permeability, extend the pain reaction time, it is anti-to reach
Scorching analgesic effect.One of most common drug of Chinese medicine rheumatism the most
Cassia twig is for treating the with a long history of " bi Zheng ", modern research shows that modern pharmacological research confirms, with cassia twig compatibility
The rheumatism immunological diseases such as rheumatoid arthritis are treated by combination side to be had anti-inflammatory and antalgic, inhibits pro-inflammatory cytokine, parahormone sample
Activity, or even have certain prevention destruction of joint, delay the effect of disease progression.Pawpaw, ramulus mori have wind-damp dispelling, sharp joint
Effect.For Bi condition, shoulder arm, joint pain are numb.
The invention has the advantages that:
1, the formula of drug not only conforms with traditional Chinese medical theory, has also adequately used contemporary pharmacology to RA pathogenesis
Newest understanding, therefore have many advantages, such as that formula is reasonable, significant in efficacy.
2, drug is raw materials used safe and non-toxic, not will produce apparent toxic side effect, and cost while treating RA
It is relatively low, it is cheap.
Excellent effect in order to better illustrate the present invention, provides following embodiment:
Embodiment 1:
By the turmeric of 50 parts by weight, the mustard seed of 15 parts by weight, the pawpaw of 15 parts by weight, the cassia twig of 15 parts by weight, 5 weight
Part ramulus mori and 5 parts by weight pepper each raw material be respectively washed, dry after, carried respectively in 80 DEG C with 10 times of water of its weight
It takes, extracts 3 times, each duration 2h, obtained extracting solution, successively merge the extracting solution after 3 extractions, filtering and be concentrated under reduced pressure
To medicinal extract, gained medicinal extract is spray-dried, and (inlet air temperature being wherein spray-dried is 170-180 DEG C, and the outlet air being spray-dried
Temperature is 70-80 DEG C) Turmeric P.E, papaya extractives, Ramulus Cinnamomi extract, Semen Brassicae Junceae extract, extract of mulberry twig are made respectively
And Fructus Piperis extract;By obtained Turmeric P.E, papaya extractives, Ramulus Cinnamomi extract, Semen Brassicae Junceae extract, extract of mulberry twig
After being mixed with the silica of the magnesium stearate of 2 parts by weight and 2 parts by weight with Fructus Piperis extract, crosses 150 mesh and sieve, mixing, uniformly
Spray into distilled water, softwood processed, granulation, dry, whole grain are packed into capsule up to capsule, sieving, encapsulated and sterilize.
Case 1
Patient 1, man, 33 years old.It is after diagnosing rheumatic arthritis, through examining its symptom:Double knees are stranded soft, pain, send out cool 3 years
It is remaining, it is then aggravated whenever its moon rains.Repeatedly take in, Western medicine, fail effectively to control symptom always.The present embodiment 1 is taken to it
Product after, 3 times a day, 3 tablets each time, after 2 weeks, lower limb pain is alleviated, and still sends out cool, and lower limb feel like jelly mitigation after two months, slightly
Power, rainy days, limbs were still sent out cool, and three months lower limb pains have been cured after medication, send out cool mitigate, not by its moon rain influence, follow-up one
Year no relapse.
Embodiment 2:
By the turmeric of 40 parts by weight, the mustard seed of 25 parts by weight, the pawpaw of 15 parts by weight, the cassia twig of 10 parts by weight, 5 weight
Part ramulus mori and 5 parts by weight pepper each raw material be respectively washed, dry after, it is 60% (wt%'s) to use containing alcohol capacity respectively
Ethyl alcohol extracts, and extracts 3 times, and each extraction time is 1h, and extraction every time uses the weight of ethyl alcohol for 5 times of the weight of each raw material;
Merge the extracting solution after 3 extractions, filter and be concentrated under reduced pressure to give medicinal extract, gained medicinal extract is spray-dried (to be wherein spray-dried
Inlet air temperature be 170-180 DEG C, and be spray-dried leaving air temp be 70-80 DEG C) be made Turmeric P.E, pawpaw extraction
Object, Ramulus Cinnamomi extract, Semen Brassicae Junceae extract, extract of mulberry twig and Fructus Piperis extract.Obtained Turmeric P.E, pawpaw are extracted
Object, Ramulus Cinnamomi extract, Semen Brassicae Junceae extract, extract of mulberry twig and Fructus Piperis extract cross 150 mesh sieve, and (5 parts are weighed with 10% starch slurry
Starch, first plus in proportion cold water stirs evenly, then adds the hot water side trimming stirring of about 5 times of starch weight, and starch slurry is made) it is viscous
Softwood is made in mixture, and granulation, dry, whole grain add the silica of the magnesium stearate and 1 parts by weight of 2 parts by weight, and mixing is equal
It is even, tabletting, to obtain the final product tablet.
Case 2
Patient 2, female, 55 years old, bilateral gonalgia 2 years+, limitation of activity.The first right side gonalgia of patient, rear left
Side knee joint also begins to pain, and pain aggravates when walking and squatting down.Through being diagnosed as rheumatic arthritis in community medical institutions, give
It gives infusion, take orally a variety of methods treatments such as Chinese and western drugs (name, amount are unknown) and acusector, refreshing lamp, partial closure, have no apparent effect
Fruit.Unfavorable, limitation of activity in the wrong is stretched in bilateral gonalgia companion swelling.After the product for taking the present embodiment 2 to it, 3 times a day,
4 tablets each time, all diseases are improved after 2 weeks, and arthralgia mitigates, and still has swelling, pain when bending and stretching;3 months posterior joint pain of medication
Swelling has been cured, and right knee tenderness is only felt.1 year no relapse of follow-up.
Embodiment 3:
By the turmeric of 60 parts by weight, the mustard seed of 10 parts by weight, the pawpaw of 10 parts by weight, the cassia twig of 5 parts by weight, 10 weight
Part ramulus mori and 5 parts by weight pepper each raw material be respectively washed, dry after, carried respectively in 100 DEG C with 10 times of water of its weight
It takes 3 times, each extraction time is 2h, merges the extracting solution after 3 extractions, filters and be concentrated under reduced pressure to give medicinal extract, gained medicinal extract
Spray-dried (inlet air temperature being wherein spray-dried is 170-180 DEG C, and the leaving air temp being spray-dried is 70-80 DEG C) system
Obtain Turmeric P.E, papaya extractives, Ramulus Cinnamomi extract, Semen Brassicae Junceae extract, extract of mulberry twig and Fructus Piperis extract.It will be acquired
Turmeric P.E, papaya extractives, Ramulus Cinnamomi extract, Semen Brassicae Junceae extract, extract of mulberry twig and Fructus Piperis extract and 2 parts by weight
Magnesium stearate and 1 parts by weight silica mixing after, cross 150 mesh sieve, mixing uniformly sprays into distilled water, softwood processed, system
Grain, dry, whole grain, are packed into capsule up to capsule, sieving, encapsulated and sterilize.
Case 3
Patient 3, man, 62 years old.Left shoulder arthralgia, half the circumference of the sleeve where it joins the shoulder is difficult when from morning, and first visit improves after massage.After 2 months again
There is both shoulders arthralgia, and involves that both hands closely refer to, joints symptoms include arthroncus, pain, the part such as metacarpophalangeal joints and double wrists are burnt
Heat, activity is unfavorable, and morning stiffness phenomenon is apparent, is " rheumatoid arthritis " through hospital's confirmation.Take prednisone piece 10mg/ days, ammonia first
Petrin piece residual effect fruit in 7.5mg/ weeks March unobvious.Health usually, without similar Disease in family.This reality is taken to it
After the product for applying example 3,3 times a day, 3 tablets each time, after 2 weeks, arthroncus, pain weaken, and night is scorching hot, and both arms are still felt when being lifted
Pain, March, posterior joint pain and swelling was cured, and self-induction is without significant discomfort.1 year no relapse of follow-up.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of drug containing Turmeric P.E, which is characterized in that be formulated by the raw material of following parts by weight:
The turmeric of 30-70 parts by weight, the mustard seed of 10-30 parts by weight, the pawpaw of 10-30 parts by weight, 5-20 parts by weight cassia twig, 5-
The pepper of the ramulus mori and 5-20 parts by weight of 20 parts by weight.
2. the drug containing Turmeric P.E as described in claim 1, which is characterized in that matched by the raw material of following parts by weight
It makes:The turmeric of 50 parts by weight, the mustard seed of 15 parts by weight, the cassia twig of 15 parts by weight, the pawpaw of 10 parts by weight, 5 parts by weight
The pepper of ramulus mori and 5 parts by weight.
3. a kind of preparation method of the drug containing Turmeric P.E, which is characterized in that include the following steps:
Weigh respectively in parts by weight the turmeric of 30-70 parts by weight, the mustard seed of 10-30 parts by weight, 10-30 parts by weight pawpaw,
The pepper of the cassia twig of 5-20 parts by weight, the ramulus mori of 5-20 parts by weight and 5-20 parts by weight is as raw material for standby, by the raw material powder
Extraction obtains Turmeric P.E, Semen Brassicae Junceae extract, papaya extractives, Ramulus Cinnamomi extract, ramulus mori and carries according to a conventional method respectively after broken
Object and Fructus Piperis extract are taken, then is carried to the Turmeric P.E, the Semen Brassicae Junceae extract, the papaya extractives, the cassia twig
Object, the extract of mulberry twig and the pharmaceutically acceptable auxiliary material of Fructus Piperis extract addition is taken to be made pharmaceutically acceptable arbitrary
Dosage form.
4. the preparation method of the drug containing Turmeric P.E as claimed in claim 3, which is characterized in that by the raw material powder
Water extraction or alcohol extracting are carried out after broken respectively, after extraction, extracting solution is successively merged, filters and be concentrated under reduced pressure to give medicinal extract, gained
Medicinal extract is spray-dried to be made corresponding extract.
5. the preparation method of the drug containing Turmeric P.E as claimed in claim 3, which is characterized in that by the raw material point
Not Fen Sui after first carry out water extraction, after extraction, successively merge extracting solution, filter and be concentrated under reduced pressure to give the first medicinal extract, will be described
First medicinal extract carries out alcohol extracting again, after extraction, successively merges extracting solution, filters and be concentrated under reduced pressure to give the second medicinal extract, gained
Two medicinal extract are spray-dried to be made corresponding extract.
6. the preparation method of the drug containing Turmeric P.E as claimed in claim 3, which is characterized in that by the raw material point
Not Fen Sui after first carry out alcohol extracting, after extraction, successively merge extracting solution, filter and be concentrated under reduced pressure to give the first medicinal extract, will be described
First medicinal extract carries out water extraction again, after extraction, successively merges extracting solution, filters and be concentrated under reduced pressure to give the second medicinal extract, gained
Two medicinal extract are spray-dried to be made corresponding extract.
7. the preparation method of the drug containing Turmeric P.E as described in any one of claim 4 to 6, which is characterized in that
The water extracts:The 10-30 times of water measured of the raw material weight after crushing is added every time, and is extracted at 80 DEG C~100 DEG C
It 1-4 times, extracts 1-3 hours every time.
8. the preparation method of the drug containing Turmeric P.E as described in any one of claim 4 to 6, which is characterized in that
The alcohol extracting includes:The 4-15 times of containing alcohol capacity measured that the raw material weight after crushing is added every time is the ethyl alcohol of 30-80wt%,
Extraction 1-4 times is extracted 1-3 hours every time.
9. the preparation method of the drug containing Turmeric P.E as claimed in claim 3, which is characterized in that the pharmacy can connect
The auxiliary material received includes one or more of disintegrant, lubricant, adhesive and filler;The drug is oral preparation, institute
The dosage form for stating oral preparation is decoction, syrup, pill, tablet, capsule, pill or granule.
10. application of the Turmeric P.E in preparing the drug for treatment of arthritis.
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Cited By (2)
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CN109395030A (en) * | 2018-12-29 | 2019-03-01 | 江苏朸健生命科技发展有限公司 | The composition and preparation method and purposes of relief from osteoarthritis disease |
EP3943096A1 (en) * | 2020-07-24 | 2022-01-26 | Star Hi Herbs Pvt Ltd. | Method of synthesizing a turmeric based composition having enhanced bioavailability |
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CN106063911A (en) * | 2016-05-24 | 2016-11-02 | 南京泽朗医药技术有限公司 | A kind of profit joint medicine |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN109395030A (en) * | 2018-12-29 | 2019-03-01 | 江苏朸健生命科技发展有限公司 | The composition and preparation method and purposes of relief from osteoarthritis disease |
EP3943096A1 (en) * | 2020-07-24 | 2022-01-26 | Star Hi Herbs Pvt Ltd. | Method of synthesizing a turmeric based composition having enhanced bioavailability |
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