CN103599409A - Traditional Chinese medicinal composition for treating prosopalgia - Google Patents
Traditional Chinese medicinal composition for treating prosopalgia Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition for treating prosopalgia. The composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 10-16 parts of chrysanthemum, 20-30 parts of angelica root, 20-30 parts of felwort, 10-16 parts of blighted wheat, 10-16 parts of selfheal, and 6-10 parts of caltrop. The traditional Chinese medicinal composition has a remarkable clinical curative effect in treating idiopathic trigeminal neuralgia, has the advantages of low medical cost and small toxic and side effect, and can be easily accepted by patients.
Description
Technical field
The invention belongs to Chinese medicine technical field, in particular to a kind of, treat prosopalgic Chinese medicine composition.
Background technology
Trigeminal neuralgia is the noun of modern medicine, belongs to motherland's medical science " wind syndrome of head " or " migraine " category.< < Plain Questions wind opinion piece of writing > > cloud: " pathogenic wind going up through acupoint FENG FU, is headache caused by pathogenic wind, visible severe headache ".In the logical headache of < < Zhang Shi doctor > >, say: " migraine person, its people has damp-phlegm usually, in addition wind is attacked it, and strongly fragrant for fire is total, belong to for a long time few sun faint the moon through ".Chinese medicine thinks that " stagnation of QI and blood may bring about pain ", trigeminal neuralgia are to be attacked by wind, cold, exopathogen.Because on top top, only wind can be, the heresy of affection of exogenous wind-cold, seek through upper criminal run top, key causes primary disease clearly.Nervous and Mental Factors also can be brought out this disease.Stagnation of QI due to depression of the liver, strongly fragrant fire-transformation of a specified duration, disturbs on burning hot pneumatic wind-fire folder expectorant and causes sun clearly and must not unfold, and head is that all sun only can.The essence of five ZANG-organs and six FU-organs China QI and blood is gathered in head on all, all pathogens, and wind, fire, phlegm-damp, blood are dissolved in meridians, stagnation of phlegm blood stasis, qi stagnation hemagglutination, checks meridians " stagnation of QI and blood may bring about pain ".Take adult's morbidity as main, and women is in the majority.Its sick ridge pathogenesis can be summarized as: exopathogen invasion and attack, stagnation of QI due to depression of the liver, stagnation of phlegm blood stasis, qi stagnation hemagglutination, stagnation of QI and blood may bring about pain.
Summary of the invention
The object of the invention is to, by prescription again after conventional medicament pharmacology is studied, provides a kind of good effect, instant effect, the little prosopalgic Chinese medicine composition for the treatment of of side effect.
The object of the present invention is achieved like this:
Treat a prosopalgic Chinese medicine composition, by the traditional Chinese medicinal material raw materials of following weight portion, be prepared from: Flos Chrysanthemi 10-16 part, Radix Angelicae Dahuricae 20-30 part, Radix Gentianae 20-30 part, Fructus Tritici Levis 10-16 part, Spica Prunellae 10-16 part, Fructus Tribuli 6-10 part.
Preferably, treat as mentioned above prosopalgic Chinese medicine composition, it is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Flos Chrysanthemi 12-15 part, Radix Angelicae Dahuricae 23-27 part, Radix Gentianae 23-27 part, Fructus Tritici Levis 12-15 part, Spica Prunellae 12-15 part, Fructus Tribuli 8-10 part.
In a most preferred embodiment of the present invention, Chinese medicine composition as above is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: 14 parts of Flos Chrysanthemis, 25 parts of the Radixs Angelicae Dahuricae, 25 parts of Radix Gentianaes, 13 parts of Fructus Tritici Levis, 13 parts of Spica Prunellaes, 8 parts of Fructus Tribulis.
Preferably, the prosopalgic Chinese medicine composition of above-mentioned treatment is oral formulations.
Again further preferably, the prosopalgic Chinese medicine composition of above-mentioned treatment is granule.
According to Chinese medicine Historical Data Data About, the pharmacologically active of above-mentioned Chinese crude drug and source are as follows:
Flos Chrysanthemi: the effect with dispelling wind, heat clearing away, improving eyesight, removing toxic substances.The diseases such as primary treatment headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling.Be selected from the dry capitulum of feverfew Flos Chrysanthemi Chrysanthemum morifolium Ramat.
The Radix Angelicae Dahuricae: wind-damp dispelling, the evacuation of pus of invigorating blood circulation, granulation promoting pain relieving.For headache, toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus.Select the root of samphire angelica anomala.
Radix Gentianae: heat clearing and damp drying; Eliminating pathogen in the liver arresting convulsion.Jaundice due to damp-heat; Urine leaching pain; Swelling of the vulva pudendal pruritus; Damp-heat vaginal discharge; The feeling of fullness in the head headache of liver and gall excess-fire; Conjunctival congestion and swelling pain; Deaf ear is swollen; Hypochondriac pain bitter taste; Calentura convulsion with spasms.Derive from root and the rhizome of gentianaceae plant Radix Gentianae (Gentiana scabra Bge.).
Fructus Tritici Levis: be shrivelled frivolous Semen Tritici aestivi, water is washed in a pan the person of floating.Except deficiency-heat; Hidroschesis.Main only fever due to yin deficiency; Night sweat; Spontaneous perspiration.
Spica Prunellae: relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, and goiter, swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension, hyperglycemia, hyperlipidemia and high blood viscosity.Select the dry fruit ear of labiate Spica Prunellae Prunella vulgaris L..
Fructus Tribuli: suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind, improving eyesight, antipruritic.Be used for having a headache dizzy, distending pain in the chest and hypochondrium, breast closes acute mastitis, conjunctival congestion cataracta, rubella pruritus.Select the dry mature fruit of zygophyllaceae plant Fructus Tribuli Tribulus terrestris L..
The preparation method that above-mentioned each Chinese crude drug is prepared into compound granular agent of the present invention, comprises the steps:
By recipe quantity, take the Flos Chrysanthemi 10-16 part cleaning up, Radix Angelicae Dahuricae 20-30 part, Radix Gentianae 20-30 part, Fructus Tritici Levis 10-16 part, Spica Prunellae 10-16 part and Fructus Tribuli 6-10 part, merge, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 1.5h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, the extractum that while being evaporated to 65 ℃ at 60-70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 75% (v/v) containing alcohol amount, stir, standing 24 hours, filter, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying, dry (condition is that inlet temperature is 100 ℃, leaving air temp is 80 ℃, temperature of charge is 80 ℃, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), pulverized 80 mesh sieves, obtain clear paste powder; According to clear paste powder: the weight ratio of dextrin 1:1～3 takes clear paste powder, dextrin and appropriate 55% ethanol, wherein 55% ethanol refers to that volumetric concentration is 55% ethanol water, clear paste powder and dextrin are dropped in trough type mixing machine, stir 20 minutes, slowly add while stirring 55% ethanol, to making soft material, with 12 order stainless steel sifts, granulate, 65～75 ℃ are dried 2 hours, take out, and cool and obtain described granule.
The clinical efficacy of traditional Chinese medicine composition for treating primary trigeminal neuralgia of the present invention is remarkable, has medical expense low, and patient is acceptant, the feature that toxicity is little, be association of activity and inertia in full side, both regulating yin and yang balance, promote again QI and blood smooth, thereby can reach the object for the treatment of must aim at the pathogenesis of disease.
The specific embodiment
Be below specific embodiments of the invention, technical scheme of the present invention is done to further description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
Embodiment 1
Crude drug prescription: 1.4 kilograms of Flos Chrysanthemis, 2.5 kilograms of the Radixs Angelicae Dahuricae, 2.5 kilograms of Radix Gentianaes, 1.3 kilograms of Fructus Tritici Levis, 1.3 kilograms of Spica Prunellaes, 0.8 kilogram of Fructus Tribuli.
Preparation technology: take the above-mentioned Chinese crude drug cleaning up by recipe quantity, merge, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 1.5h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, the extractum that while being evaporated to 65 ℃ at 60-70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 75% (v/v) containing alcohol amount, stir, standing 24 hours, filter, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying, dry (condition is that inlet temperature is 100 ℃, leaving air temp is 80 ℃, temperature of charge is 80 ℃, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), pulverized 80 mesh sieves, obtain clear paste powder; According to clear paste powder: the weight ratio of dextrin 1:2.5 takes clear paste powder, dextrin and appropriate 55% ethanol, wherein 55% ethanol refers to that volumetric concentration is 55% ethanol water, clear paste powder and dextrin are dropped in trough type mixing machine, stir 20 minutes, slowly add while stirring 55% ethanol, to making soft material, with 12 order stainless steel sifts, granulate, 65～75 ℃ are dried 2 hours, take out, cool and obtain described granule, by every bag of 15g packing.
Embodiment 2
Crude drug prescription: 1.6 kilograms of Flos Chrysanthemis, 2.2 kilograms of the Radixs Angelicae Dahuricae, 3 kilograms of Radix Gentianaes, 1.5 kilograms of Fructus Tritici Levis, 1.6 kilograms of Spica Prunellaes, 1 kilogram of Fructus Tribuli.
Preparation technology: take the above-mentioned Chinese crude drug cleaning up by recipe quantity, merge, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 1.5h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, the extractum that while being evaporated to 65 ℃ at 60-70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 75% (v/v) containing alcohol amount, stir, standing 24 hours, filter, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying, dry (condition is that inlet temperature is 100 ℃, leaving air temp is 80 ℃, temperature of charge is 80 ℃, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), pulverized 80 mesh sieves, obtain clear paste powder; According to clear paste powder: the weight ratio of dextrin 1:3 takes clear paste powder, dextrin and appropriate 55% ethanol, wherein 55% ethanol refers to that volumetric concentration is 55% ethanol water, clear paste powder and dextrin are dropped in trough type mixing machine, stir 20 minutes, slowly add while stirring 55% ethanol, to making soft material, with 12 order stainless steel sifts, granulate, 65～75 ℃ are dried 2 hours, take out, cool and obtain described granule, by every bag of 15g packing.
Embodiment 3
Crude drug prescription: 1 kilogram of Flos Chrysanthemi, 3 kilograms of the Radixs Angelicae Dahuricae, 2.1 kilograms of Radix Gentianaes, 1 kilogram of Fructus Tritici Levis, 1.5 kilograms of Spica Prunellaes, 0.8 kilogram of Fructus Tribuli.
Preparation technology: take the above-mentioned Chinese crude drug cleaning up by recipe quantity, merge, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 1.5h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, the extractum that while being evaporated to 65 ℃ at 60-70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 75% (v/v) containing alcohol amount, stir, standing 24 hours, filter, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying, dry (condition is that inlet temperature is 100 ℃, leaving air temp is 80 ℃, temperature of charge is 80 ℃, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), pulverized 80 mesh sieves, obtain clear paste powder; According to clear paste powder: the weight ratio of dextrin 1:3 takes clear paste powder, dextrin and appropriate 55% ethanol, wherein 55% ethanol refers to that volumetric concentration is 55% ethanol water, clear paste powder and dextrin are dropped in trough type mixing machine, stir 20 minutes, slowly add while stirring 55% ethanol, to making soft material, with 12 order stainless steel sifts, granulate, 65～75 ℃ are dried 2 hours, take out, cool and obtain described granule, by every bag of 15g packing.
The experimental study of embodiment 4 Chinese medicine granules treatment affected nerves of patients with trigeminal neuralgias
32 routine affected nerves of patients with trigeminal neuralgias, male 13 examples, female l9 example; Age 30-78 year, average (52.3 ± 8.7) year; 6 months-l2 of the course of disease, average (2.0 ± 0.7) year.Diagnostic criteria is made a definite diagnosis with reference to the standard of the classical trigeminal neuralgias of diagnosis (primary trigeminal neuralgia) of international headache association (IHS) in 1988 formulation.All patients 2 bags/d of Chinese medicine granules (being prepared from according to the prescription of embodiment 1 and technique) that takes after mixing it with water, each bag sooner or later, continuous use 4 weeks.After treatment finishes, by following canonical statistics curative effect:
Cure: pain outbreak disappears, and follows up a case by regular visits to and within 3 months, has no recurrence;
Take a turn for the better: attack times reduce and (or) pain degree alleviates during outbreak;
Invalid: attack times and outbreak pain degree are without alleviating.
Adopt Chinese medicine granules of the present invention to the therapeutic outcome of 32 routine affected nerves of patients with trigeminal neuralgias to be: to cure l3 example, 17 examples that take a turn for the better, invalid 2 examples, cure rate 40.6%, total effective rate 93.8%.
Claims (6)
1. the prosopalgic Chinese medicine composition for the treatment of, is characterized in that: described Chinese medicine composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Flos Chrysanthemi 10-16 part, Radix Angelicae Dahuricae 20-30 part, Radix Gentianae 20-30 part, Fructus Tritici Levis 10-16 part, Spica Prunellae 10-16 part, Fructus Tribuli 6-10 part.
2. the prosopalgic Chinese medicine composition for the treatment of according to claim 1, is characterized in that: described Chinese medicine composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Flos Chrysanthemi 12-15 part, Radix Angelicae Dahuricae 23-27 part, Radix Gentianae 23-27 part, Fructus Tritici Levis 12-15 part, Spica Prunellae 12-15 part, Fructus Tribuli 8-10 part.
3. treat according to claim 2 prosopalgic Chinese medicine composition, it is characterized in that: described Chinese medicine composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: 14 parts of Flos Chrysanthemis, 25 parts of the Radixs Angelicae Dahuricae, 25 parts of Radix Gentianaes, 13 parts of Fructus Tritici Levis, 13 parts of Spica Prunellaes, 8 parts of Fructus Tribulis.
4. described in claim 1 or 2 or 3, treat prosopalgic Chinese medicine composition, it is characterized in that: described Chinese medicine composition is oral formulations.
5. described in claim 1 or 2 or 3, treat prosopalgic Chinese medicine composition, it is characterized in that: described Chinese medicine composition is granule.
6. described in claim 1 or 2 or 3, treat prosopalgic Chinese medicine composition, it is characterized in that: described trigeminal neuralgia is primary trigeminal neuralgia.
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| CN201310569940.8A CN103599409B (en) | 2013-11-16 | 2013-11-16 | One treats prosopalgic Chinese medicine composition |
| CN201510722911.XA CN105148104A (en) | 2013-11-16 | 2013-11-16 | Method for preparing traditional Chinese medicine composition granules for treating prosopalgia |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105079552A (en) * | 2015-09-06 | 2015-11-25 | 付丽娜 | Preparation for treating prosopalgia and preparation method |
| CN105748807A (en) * | 2016-04-05 | 2016-07-13 | 胡佳 | Traditional Chinese medicine for treating primary trigeminal neuralgia and preparation method |
| CN106138810A (en) * | 2016-07-30 | 2016-11-23 | 刘建飞 | One treats prosopalgic Chinese medicine preparation |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879778A (en) * | 2005-06-15 | 2006-12-20 | 白云新 | Headache-treating medicine |
| CN101549104A (en) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | Traditional Chinese medicine composition for treating trigeminal neuralgia and preparation method thereof |
| CN101766767A (en) * | 2010-02-27 | 2010-07-07 | 王松国 | Chinese medicine composition for headaches |
| CN102228579A (en) * | 2011-06-15 | 2011-11-02 | *** | Medicament for treating prosopalgia |
| CN102949470A (en) * | 2012-11-14 | 2013-03-06 | 西安福安创意咨询有限责任公司 | Traditional Chinese medicine dispersible tablet for treating headache and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103263531B (en) * | 2013-05-30 | 2014-07-02 | 崔新明 | Chinese medicine composition for treating prosopalgia and preparation method thereof |
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2013
- 2013-11-16 CN CN201510722911.XA patent/CN105148104A/en not_active Withdrawn
- 2013-11-16 CN CN201310569940.8A patent/CN103599409B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879778A (en) * | 2005-06-15 | 2006-12-20 | 白云新 | Headache-treating medicine |
| CN101549104A (en) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | Traditional Chinese medicine composition for treating trigeminal neuralgia and preparation method thereof |
| CN101766767A (en) * | 2010-02-27 | 2010-07-07 | 王松国 | Chinese medicine composition for headaches |
| CN102228579A (en) * | 2011-06-15 | 2011-11-02 | *** | Medicament for treating prosopalgia |
| CN102949470A (en) * | 2012-11-14 | 2013-03-06 | 西安福安创意咨询有限责任公司 | Traditional Chinese medicine dispersible tablet for treating headache and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105079552A (en) * | 2015-09-06 | 2015-11-25 | 付丽娜 | Preparation for treating prosopalgia and preparation method |
| CN105748807A (en) * | 2016-04-05 | 2016-07-13 | 胡佳 | Traditional Chinese medicine for treating primary trigeminal neuralgia and preparation method |
| CN106138810A (en) * | 2016-07-30 | 2016-11-23 | 刘建飞 | One treats prosopalgic Chinese medicine preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105148104A (en) | 2015-12-16 |
| CN103599409B (en) | 2015-09-23 |
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