CN108324700A - A kind of enteric slow release oxytetracycline calcium pre-mixing agent and preparation method thereof - Google Patents
A kind of enteric slow release oxytetracycline calcium pre-mixing agent and preparation method thereof Download PDFInfo
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- CN108324700A CN108324700A CN201810303185.1A CN201810303185A CN108324700A CN 108324700 A CN108324700 A CN 108324700A CN 201810303185 A CN201810303185 A CN 201810303185A CN 108324700 A CN108324700 A CN 108324700A
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- enteric
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- terramycin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
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Abstract
The present invention proposes a kind of enteric slow release oxytetracycline calcium pre-mixing agent and preparation method thereof, solve the problems, such as that bioavilability is low in animal body for terramycin in the prior art, a kind of enteric slow release oxytetracycline calcium pre-mixing agent, the pre-mixing agent includes capsule core and enteric coating layer, and the capsule core comprises the following raw materials by weight percent：Terramycin 8 40%, adhesive 1 20%, pore-foaming agent 10 30% and lubricant 15 40%, the enteric coating layer comprises the following raw materials by weight percent：Brazil wax 20 50%; palm grease 10 30%; organic solvent 15 30%, which can protect terramycin, it is made not to be dissolved and absorb in stomach; enterosoluble substance is disintegrated rapidly after entering enteron aisle; terramycin is released, to regulate and control to enteric microorganism bacterium colony, improves enteron aisle state; the utilization rate for improving nutriment, to reach the function of growth promotion and health care.
Description
Technical field
The present invention relates to technical field of pharmaceuticals, a kind of enteric slow release oxytetracycline calcium pre-mixing agent and its preparation side are particularly related to
Method.
Background technology
Terramycin is the antibiotic developed by the U.S. in 1949.It is China's production and most commonly used antibiotic.Soil is mould
Element is greyish white or golden yellow crystalline powder.It is usually produced and used with terramycin sodium or calcium salt, terramycin can be improved in this way
Stability.It has extensive antimicrbial power to gram-positive bacteria, negative bacterium, Leptospira, Rickettsial and large-scale virus,
It is effective drug of the breathing problem and dysentery to chicken, pig and calf.The most important characteristics of the antibacterial activity of terramycin are medicines
Object molecule includes the tetracycline core of a linear fusion.The simplest tetracycline molecule with antibacterial activity of structure is 62 de-
Oxygen 262 declomycins, this structure is considered as the pharmacophoric group of minimum.Terramycin is by preventing aminoacyl tRAN and bacterium core
Sugared body is in conjunction with inhibiting bacterio protein to synthesize.
Oxytetracycline Hcl USP is at home and abroad used with preventive dose in feed in Production of Livestock and Poultry, it is therefore an objective to promote growth of animals or poultry.
Terramycin is added in swine rations can improve sow reproductive performance, improve Market pigs performance and control grice diarrhoea, be pig
Field health and the choice drug for preventing disease.Currently, as country forbids adding olaquindox and colistine sulfate in feed
Etc. antibacterials policy execution, terramycin aquaculture as health care medication and prevent disease medication ratio it is increasing.
Oxytetracycline Hcl USP major defect is easily to be absorbed by gastrointestinal tract very much through digesting canal drug administration, and can develop immunity to drugs.Simple stomach is dynamic
Object reached peak concentration at 2-4 hours, widely distributed in vivo after absorption, easily penetrated into chest, abdominal cavity and milk；Also it can pass through placenta
Barrier enters fetal circulation；It is stored in courage, spleen in vivo, is especially easily deposited on bone and tooth.Mainly by kidney excretion, in bile
With concentration in urine height, be conducive to the treatment of biliary tract and urethral infection.
With the long-time service of feeding terramycin, bacterium increases the drug resistance of terramycin, in actual use, Yong Huyi
As by one times of recommended dose even more times of uses.When clinical research is shown for growth promotion, effect of the terramycin in enteron aisle
It is to improve stomach bad border, extends its release time, it is to improve drug effect to reduce dosage to the decomposition absorption of Oxytetracycline Hcl USP to avoid gastric juice
Good solution.Feeding terramycin available on the market is mainly that Direct spraying forms after addition calcium carbonate in zymotic fluid, is belonged to
Full fermentation class product.To improve the utilization rate of terramycin, destruction and absorption of the gastric juice to Oxytetracycline Hcl USP are reduced, makes terramycin in intestines
Uniform slow release in road, it is also necessary to which the preparation process for further increasing terramycin is horizontal.
Invention content
A kind of enteric slow release oxytetracycline calcium pre-mixing agent of present invention proposition and preparation method thereof, solves native mould in the prior art
The plain low problem of bioavilability in animal body.
The technical proposal of the invention is realized in this way：A kind of enteric slow release oxytetracycline calcium pre-mixing agent, the pre-mixing agent include
Capsule core and enteric coating layer, the capsule core comprise the following raw materials by weight percent：Terramycin 8-40%, adhesive 1-20%,
Pore-foaming agent 10-30% and lubricant 15-40%,
The enteric coating layer comprises the following raw materials by weight percent：Brazil wax 20-50%, palm grease 10-
30%, organic solvent 15-30%.
Preferably, described adhesive is in hydroxypropyl methyl cellulose, sodium carboxymethylcellulose, polyvinylpyrrolidone
It is a kind of.
Preferably, the pore-foaming agent is one kind in glucose, sucrose, chitosan.
Preferably, the lubricant is one kind in superfine silica gel powder, calcium carbonate, magnesium stearate.
Preferably, the organic solvent is polyethylene glycol 2000.
The present invention proposes a kind of preparation method of enteric slow release oxytetracycline calcium pre-mixing agent, including step again：
1) capsule core raw material terramycin, adhesive, pore-foaming agent and lubricant are weighed by weight percentage, crushed 80 mesh respectively
It being mixed evenly after sieve, softwood is made in the rear water that capsule core weight 20-30% is added,
2) softwood is added in screw extruder, uses hole diameter of sieve (perforated) plate 0.3-0.6mm, extrusion, bar obtained
It is transferred in spheronizator, it is 1000rpm to control round as a ball rate, is rolled onto pellet, and the pellet is done under the conditions of 60 DEG C -70 DEG C
Dry, moisture controls within 8%, and by shaking screen after drying, sieve is 30-50 mesh, obtains oxytetracycline calcium vegetable pill；
3) enteric coating layer is weighed by weight percentage, and the enteric coating layer is coated the oxytetracycline calcium vegetable pill,
Coating is sprayed using fluidized-bed coating machine bottom side, the process conditions of the coating：Whiff pressure 0.4MPa；Hydrojet flow velocity 100-
2000mL/ minutes；50-90 DEG C of stream temperature inlet air temperature；Time 2-4 hour；85% or more the mistake of product granularity eventually formed
20 mesh analysis sieve.
Beneficial effects of the present invention：
The present invention carries out pellet granulation to terramycin, and manufactured small form is no longer that dust state greatly reduces drug
Using when cross contamination, and increase mobility.Packet last layer enterosoluble substance height palm oil, the substance energy are sprayed in outer layer
Protection terramycin is not dissolved release in stomach, and enterosoluble substance is disintegrated after entering enteron aisle, releases terramycin in enteron aisle chyme
Middle long-time plays its antibacterial and bacteriostasis.Terramycin coated preparation is insoluble in stomach, is sustained after reaching animal intestinal tract, can be
It is distributed to entire enteron aisle evenly, is come into full contact with pathogenic microorganism, to reach the breeding for inhibiting pathogenic microorganism, prevents diarrhea
Effect.Terramycin will not lead to gastric disorder causing nausea and vomiting to stomach without pessimal stimulation after enteric coating.Enteric coating is in hydrochloric acid in gastric juice
Property environment be not damaged, all the accurate enteron aisles that reach play a role active ingredient.Bitter taste and medicine are masked after terramycin is coated
Object stink improves the palatability of feed.The present invention can improve oxytetracycline calcium at 4 times of function and effect of enteron aisle, such as feeding per ton
The 100ppm oxytetracycline calciums of material addition coating, then be equivalent to general formulation 400ppm oxytetracycline calciums；
The pre-mixing agent can protect terramycin, it is made not to be dissolved and absorb in stomach, the enterosoluble substance after entering enteron aisle
Rapid disintegration, releases terramycin, to regulate and control to enteric microorganism bacterium colony, improves enteron aisle state, improves nutriment
Utilization rate, to reach the function of growth promotion and health care.Meanwhile sustained-release dosage type is made and makes drug extended durations of action, it uses
Medicine number is reduced, and is reduced raiser's drug cost, is improved economic benefit.
Description of the drawings
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technology description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention without having to pay creative labor, may be used also for those of ordinary skill in the art
With obtain other attached drawings according to these attached drawings.
Fig. 1 is the technological process of production schematic diagram of the present invention；
Specific implementation mode
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common
The every other embodiment that technical staff is obtained without creative efforts belongs to the model that the present invention protects
It encloses.
Embodiment one
As shown in Figure 1, a kind of preparation method of enteric slow release oxytetracycline calcium pre-mixing agent, including step：
1) capsule core raw material, 5kg terramycin, 10kg hydroxypropyl methyl celluloses, 10kg chitosans are weighed by weight percentage
With 40kg calcium carbonate, it is mixed evenly after crushed 80 mesh sieve respectively, softwood is made in the rear water that 10kg is added,
2) softwood is added in screw extruder, using hole diameter of sieve (perforated) plate 0.3mm, extrusion, bar obtained is transferred to
In spheronizator, it is 1000rpm to control round as a ball rate, is rolled onto pellet, and the pellet is dry under the conditions of 60 DEG C, moisture control
Within 8%, by shaking screen after drying, sieve is 30 mesh, obtains oxytetracycline calcium vegetable pill；
3) enteric coating layer is weighed by weight percentage, takes 10kg Brazil waxs, 20kg palm greases that it is poly- to be dissolved in 15kg
In ethylene glycol 2000, the enteric coating layer is coated the oxytetracycline calcium vegetable pill, coating uses fluidized-bed coating machine bottom
Side spray, the process conditions of the coating：Whiff pressure 0.4MPa；Hydrojet flow velocity 1000mL/ minutes；Stream temperature inlet air temperature 50
℃；Time 2 h；85% or more the product granularity eventually formed crosses 20 mesh analysis sieve.
Embodiment two
As shown in Figure 1, a kind of preparation method of enteric slow release oxytetracycline calcium pre-mixing agent, including step：
1) capsule core raw material 10kg terramycin, 10kg hydroxypropyl methyl celluloses, 15kg chitosans are weighed by weight percentage
With 25kg calcium carbonate, it is mixed evenly after crushed 80 mesh sieve respectively, softwood is made in the rear water that capsule core weight 25% is added,
2) softwood is added in screw extruder, using hole diameter of sieve (perforated) plate 0.3mm, extrusion, bar obtained is transferred to
In spheronizator, it is 1000rpm to control round as a ball rate, is rolled onto pellet, and the pellet is dry under the conditions of 65 DEG C, moisture control
Within 8%, by shaking screen after drying, sieve is 30-50 mesh, obtains oxytetracycline calcium vegetable pill；
3) enteric coating layer is weighed by weight percentage, takes 15kg Brazil waxs, 20kg palm greases that it is poly- to be dissolved in 20kg
In ethylene glycol 2000, the enteric coating layer is coated the oxytetracycline calcium vegetable pill, coating uses fluidized-bed coating machine bottom
Side spray, the process conditions of the coating：Whiff pressure 0.4MPa；Hydrojet flow velocity 1200mL/ minutes；Stream temperature inlet air temperature 70
℃；3 hours time；85% or more the product granularity eventually formed crosses 20 mesh analysis sieve.
Embodiment three
As shown in Figure 1, a kind of preparation method of enteric slow release oxytetracycline calcium pre-mixing agent, including step：
1) capsule core raw material 20kg terramycin, 15kg hydroxypropyl methyl celluloses, 15kg chitosans are weighed by weight percentage
It with 10kg calcium carbonate, is mixed evenly after crushed 80 mesh sieve respectively, the rear water that capsule core weight 20-30% is added is made soft
Material,
2) softwood is added in screw extruder, using hole diameter of sieve (perforated) plate 0.3mm, extrusion, bar obtained is transferred to
In spheronizator, it is 1000rpm to control round as a ball rate, is rolled onto pellet, and the pellet is dry under the conditions of 70 DEG C, moisture control
Within 8%, by shaking screen after drying, sieve is 50 mesh, obtains oxytetracycline calcium vegetable pill；
3) enteric coating layer is weighed by weight percentage, takes 15kg Brazil waxs, 20kg palm greases that it is poly- to be dissolved in 30kg
In ethylene glycol 2000, the enteric coating layer is coated the oxytetracycline calcium vegetable pill, coating uses fluidized-bed coating machine bottom
Side spray, the process conditions of the coating：Whiff pressure 0.4MPa；Hydrojet flow velocity 100-2000mL/ minutes；Stream temperature is into wind-warm syndrome
80 DEG C of degree；3 hours time；85% or more the product granularity eventually formed crosses 20 mesh analysis sieve.
Using the cumulative release percentage of vitro release as evaluation index, to the alimentary canal of enteric slow release terramycin pre-mixing agent
Burst size is measured.
Table 1
As seen from the above table, bioavilability is high in animal body for the oxytetracycline calcium pre-mixing agent that prepared by the present invention.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
With within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention god.
Claims (6)
1. a kind of enteric slow release oxytetracycline calcium pre-mixing agent, which includes capsule core and enteric coating layer, which is characterized in that the ball
Core comprises the following raw materials by weight percent：Terramycin 8-40%, adhesive 1-20%, pore-foaming agent 10-30% and lubricant
15-40%,
The enteric coating layer comprises the following raw materials by weight percent：Brazil wax 20-50%, palm grease 10-30%,
Organic solvent 15-30%.
2. a kind of enteric slow release oxytetracycline calcium pre-mixing agent as described in claim 1, it is characterised in that：
Described adhesive is one kind in hydroxypropyl methyl cellulose, sodium carboxymethylcellulose, polyvinylpyrrolidone.
3. a kind of enteric slow release oxytetracycline calcium pre-mixing agent as described in claim 1, it is characterised in that：
The pore-foaming agent is one kind in glucose, sucrose, chitosan.
4. a kind of enteric slow release oxytetracycline calcium pre-mixing agent as described in claim 1, it is characterised in that：
The lubricant is one kind in superfine silica gel powder, calcium carbonate, magnesium stearate.
5. a kind of enteric slow release oxytetracycline calcium pre-mixing agent as described in claim 1, it is characterised in that：
The organic solvent is polyethylene glycol 2000.
6. a kind of preparation method of enteric slow release oxytetracycline calcium pre-mixing agent as described in any one of claim 1 to 5, feature
It is, including step：
1) capsule core raw material terramycin, adhesive, pore-foaming agent and lubricant are weighed by weight percentage, after crushed 80 mesh sieve respectively
It being mixed evenly, softwood is made in the rear water that capsule core weight 20-30% is added,
2) softwood is added in screw extruder, using hole diameter of sieve (perforated) plate 0.3-0.6mm, extrusion, bar obtained is transferred to
In spheronizator, it is 1000rpm to control round as a ball rate, is rolled onto pellet, and the pellet is dry under the conditions of 60 DEG C -70 DEG C, water
Sub-control system is within 8%, and by shaking screen after drying, sieve is 30-50 mesh, obtains oxytetracycline calcium vegetable pill；
3) enteric coating layer is weighed by weight percentage, the enteric coating layer is coated the oxytetracycline calcium vegetable pill, is coated
It is sprayed using fluidized-bed coating machine bottom side, the process conditions of the coating：Whiff pressure 0.4MPa；Hydrojet flow velocity 100-2000mL/
Minute；50-90 DEG C of stream temperature inlet air temperature；Time 2-4 hour；85% or more the product granularity eventually formed crosses the analysis of 20 mesh
Sieve.
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| CN201810303185.1A CN108324700A (en) | 2018-04-07 | 2018-04-07 | A kind of enteric slow release oxytetracycline calcium pre-mixing agent and preparation method thereof |
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| CN201810303185.1A CN108324700A (en) | 2018-04-07 | 2018-04-07 | A kind of enteric slow release oxytetracycline calcium pre-mixing agent and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3646852A1 (en) * | 2018-10-29 | 2020-05-06 | Fraunhofer Gesellschaft zur Förderung der Angewand | Tetracycline complexes with sustained activity |
| WO2020089249A1 (en) * | 2018-10-29 | 2020-05-07 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Tetracycline complexes with sustained activity |
| RU2806036C2 (en) * | 2018-10-29 | 2023-10-25 | Фраунхофер-Гезелльшафт Цур Фердерунг Дер Ангевандтен Форшунг Е.Ф. | Tetracycline complexes with sustainable activity |
-
2018
- 2018-04-07 CN CN201810303185.1A patent/CN108324700A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3646852A1 (en) * | 2018-10-29 | 2020-05-06 | Fraunhofer Gesellschaft zur Förderung der Angewand | Tetracycline complexes with sustained activity |
| WO2020089249A1 (en) * | 2018-10-29 | 2020-05-07 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Tetracycline complexes with sustained activity |
| CN113557008A (en) * | 2018-10-29 | 2021-10-26 | 弗劳恩霍夫应用研究促进协会 | Tetracycline complex with sustained activity |
| RU2806036C2 (en) * | 2018-10-29 | 2023-10-25 | Фраунхофер-Гезелльшафт Цур Фердерунг Дер Ангевандтен Форшунг Е.Ф. | Tetracycline complexes with sustainable activity |
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