CN103271931B - Compound acetylisovalery tylosin tartrate pellet and preparation method thereof - Google Patents
Compound acetylisovalery tylosin tartrate pellet and preparation method thereof Download PDFInfo
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- CN103271931B CN103271931B CN201310187035.6A CN201310187035A CN103271931B CN 103271931 B CN103271931 B CN 103271931B CN 201310187035 A CN201310187035 A CN 201310187035A CN 103271931 B CN103271931 B CN 103271931B
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Abstract
The invention discloses a compound acetylisovalery tylosin tartrate pellet. The compound acetylisovalery tylosin tartrate pellet is made by wrapping a drug-loading pellet core by adopting a coating material, wherein the drug-loading pellet core comprises the following components in percentage by weight: 1-30% of acetylisovalery tylosin tartrate, 1-30% of sulfadimidine, 5-20% of lactose, 5-25% of corncob powder, 10-60% of starch, 15-35% of microcrystalline cellulose and 0.5-12% of pelletizing binding agent; and weight of the coating material is not more than 8% of the total weight of the compound acetylisovalery tylosin tartrate pellet. The compound acetylisovalery tylosin tartrate pellet has a better clinical treatment effect, application amount of acetylisovalery tylosin tartrate can be reduced, and production cost can be saved; and drug release can be delayed, drug action time can be prolonged, and long-acting effect can be achieved, so that administration frequency is reduced and labour intensity can be alleviated.
Description
Technical field
The present invention relates to a kind of compound acetylisovalery tylosin tartrate pellet and preparation method thereof, belong to technical field of veterinary.
Background technology
Safe ten thousand rhzomorphs of tartaric acid and acetylisovaleryl tylosin (Acetylisovalery Tylosin Tartrate) are by the commercial brand-new macrolide antibiotics of Yi Ke animal health-care product limited company of Britain.Be the derivant that Tylosin A generates through chemical improvement, all have stronger antibacterial activity to mycoplasma, spirillum, most of gram positive bacteria and part gram negative bacteria, especially large especially to the antibacterial activity of mycoplasma; Be mainly used in the mycoplasma infection of preventing and treating chicken, turkey and other animal, dysentery, the contagious pleuropneumonia of pig, disease of breathing, Proliferative Enteritis (PPE) etc. are the special antibiotic of poultry.
At present, Thailand ten thousand rhzomorph common on market is common pre-mixing agent and soluble powder, because preparation process is simple, make the bioavailability of medicine low, be subject to the impact of gastric acid, and medicine itself easily produces serious influence to gastrointestinal tract, ordinary preparation abnormal smells from the patient is large and bitter in the mouth easily disperses again so that palatability difference feed intake declines simultaneously, so that curative effect of medication reduces, and does not reach ideal effect; On the other hand, simple pre-mixing agent is blended in feedstuff, and multiple components, as acidulant, high-micro-element, electrolyte etc., chemical reaction occurs easily and in feedstuff, its drug effect is declined, and ordinary preparation administration number of times adds hand labor intensity; And the patent of invention that Chinese Patent Application No. is " 201110009247.6 " discloses a boar safe ten thousand rhzomorph injection and preparation method thereof; every 100 milliliters of injection contain the glyceryl triacetate of 20 grams of Acetylisovaleryl Tylosin Tartrates, 20 ~ 35 grams of propylene glycol, 10 ~ 15 grams of N, N-diformyl acetamides, 2 ~ 4 grams of benzyl alcohol, 0.1 ~ 1.0 gram of ditertbutylparacresol and surpluses.But it is large also to there is hand labor intensity with safe ten thousand rhzomorph injection in this boar, and injection to pig can produce very strong stress shortcoming.
Therefore, urgent clinical needs will be stablized, the safe ten thousand rhzomorph novel formulation of tartaric acid efficient, easy to use, to ensure its clinical efficacy, strengthen palatability and alleviate hand labor intensity.
Summary of the invention
For the deficiencies in the prior art, first object of the present invention is that the present invention has better clinical therapeutic efficacy in order to provide a kind of compound acetylisovalery tylosin tartrate pellet, and can reduce the use amount of safe ten thousand rhzomorphs of tartaric acid, saves production cost; The present invention simultaneously can improve medicine stability, make medicine from the impact of feed ingredient and gastric acid, cover adverse drug abnormal smells from the patient, increase palatability, reduce to gastrointestinal stimulate, and good fluidity again outsourcing painted clothing layer easily make mixed feeding even, decrease dust, the release of medicine can be delayed, prolong drug action time simultaneously, play long-acting and alleviate hand labor intensity to reduce administration number of times.
Second object of the present invention is the preparation method in order to provide a kind of compound acetylisovalery tylosin tartrate pellet, and the method has that preparation technology is simple, less energy consumption and the feature easily implemented.
Realize first object of the present invention to reach by taking following technical scheme:
A kind of compound acetylisovalery tylosin tartrate pellet, is characterized in that, wraps up the medicine carrying ball heart make by coating material;
1) described medicine carrying ball pericardium draws together the component of following weight percentage: tartaric acid safe ten thousand rhzomorph 1-30%, sulfadimidine 1-30%, lactose 5-20%, maize cob meal 5-25%, starch 10-60%, microcrystalline Cellulose 15-35%, granulation binders 0.5-12%;
2) described coating material weight is no more than 8% of described compound acetylisovalery tylosin tartrate pellet gross weight; Coating material is selected from one or more in hydroxypropyl emthylcellulose, hydroxyethyl-cellulose, sodium carboxymethyl cellulose, methylethylcellulose, Polyethylene Glycol, polyvinylpyrrolidone.
Preferably, described medicine carrying ball pericardium draws together the component of following weight percentage: the safe ten thousand rhzomorph 5-20% of tartaric acid; Sulfadimidine 5-20%; Lactose 10-15%; Maize cob meal 10-20%; Starch 20-50%; Microcrystalline Cellulose 15-30%; Granulation binders 1-8%.
Preferably, the described medicine carrying ball heart is that size is not more than 30 object micropartical.
Preferably, described granulation binders is selected from the compositions of one or more in gelatin, polyvinylpyrrolidone, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, methylcellulose, ethyl cellulose or starch slurry.
Realize second object of the present invention to reach by taking following technical scheme:
A preparation method for compound acetylisovalery tylosin tartrate pellet, is characterized in that carrying out according to the following steps:
1) compositions of one or more in gelatin, polyvinylpyrrolidone, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, methylcellulose, ethyl cellulose or starch is weighed, as granulation binders by formula;
2) weigh safe ten thousand rhzomorphs of tartaric acid, sulfadimidine, lactose, maize cob meal, starch, microcrystalline Cellulose mix homogeneously by formula, then add step 1) gained granulation binders and make soft material, via extruding, ball blast obtains the medicine carrying ball heart;
3) by step 2) the gained medicine carrying ball heart carries out drying, sieves out 30-50 object screening thing after drying;
4) be the coating solution of 10% by previously prepared for the one or more combination thing in hydroxypropyl emthylcellulose, hydroxyethyl-cellulose, sodium carboxymethyl cellulose, methylethylcellulose, Polyethylene Glycol, polyvinylpyrrolidone one-tenth solid content, then step 3) gained screening thing is sprayed in coating solution and carry out Cotton seeds, coated rear continuation is dry, obtains the safe ten thousand rhzomorph micropills of described tartaric acid.
Preferably, in step 3), the described medicine carrying ball heart is put into fluid bed and carries out drying.
Preferably, in step 4), the screening thing sieved is put into fluid bed, and inlet temperature is 40-60 DEG C, sprays into coating solution Cotton seeds, the follow-up continuous fluidized drying 15-30 minute of coating.
Beneficial effect of the present invention is:
1, Thailand ten thousand rhzomorph in formula of the present invention belongs to imitates antibacterial soon, and sulfadimidine suppresses the slow acting type antibacterial of the wide spectrum of its growth and breeding by disturbing the folic acid metabolism of sensitive organism, both share, and can obtain accumulative action, make up respective antimicrobial spectrum weak point.Safe for tartaric acid ten thousand rhzomorphs, sulfadimidine are made micropill simultaneously, there is better clinical therapeutic efficacy, and the use amount of safe ten thousand rhzomorphs of tartaric acid can have been reduced, saved production cost; The present invention simultaneously can improve medicine stability, make medicine from the impact of feed ingredient and gastric acid, cover adverse drug abnormal smells from the patient, increase palatability, reduce to gastrointestinal stimulate, and good fluidity again outsourcing painted clothing layer easily make mixed feeding even, decrease dust, the release of medicine can be delayed, prolong drug action time simultaneously, play long-acting and alleviate hand labor intensity to reduce administration number of times.Safe ten thousand rhzomorphs of tartaric acid on veterinary clinic unfavorable can be avoided and give full play to its effect; On the other hand, medication is convenient, and spice adds, and does not affect the feed intake of animal.
2, compound acetylisovalery tylosin tartrate pellet preparation method of the present invention has technique simply, less energy consumption, and production safety, easily realizes, the obtained even-grained advantage of micropill.
Detailed description of the invention
Below, in conjunction with detailed description of the invention, the present invention is described further:
Embodiment 1:
A kind of compound acetylisovalery tylosin tartrate pellet, comprise coating and the medicine carrying ball heart, the described medicine carrying ball heart is that size is not more than 30 object micropartical, and wherein medicine carrying ball pericardium is containing, for example the component of lower percetage by weight: safe ten thousand rhzomorphs 2% of tartaric acid; Sulfadimidine 2%; Lactose 10%; Maize cob meal 10%; Starch 58%; Microcrystalline Cellulose 15%; Granulation binders 3%.
Wherein, described granulation binders is gelatin adhesive.Described coat weight is 2% of described compound acetylisovalery tylosin tartrate pellet gross weight, and wherein coating material is hydroxypropyl emthylcellulose.
The preparation method of described compound acetylisovalery tylosin tartrate pellet, comprises following concrete steps:
1) following each component is weighed respectively by following percentage by weight: tartaric acid safe ten thousand rhzomorphs 2%, sulfadimidine 2%, lactose 10%, maize cob meal 10%, starch 58%, microcrystalline Cellulose 15%, gelatin granulation binders 3%.By safe for tartaric acid ten thousand rhzomorphs, sulfadimidine, lactose, maize cob meal, starch, microcrystalline Cellulose mix homogeneously;
2) add in the gelatin granulation binders prepared in step 1) gained mixture and make soft material, via extruding, ball blast obtains the medicine carrying ball heart;
3) by step 2) the gained medicine carrying ball heart carries out drying, screening 30-50 object screening thing after dry;
4) step 3) gained screening thing is put into fluid bed, inlet temperature is 45 DEG C, leaving air temp 30 DEG C, sprays into the coating solution modulated with hydroxypropyl emthylcellulose and carries out Cotton seeds, dry 20 minutes of coated rear continuation, obtains described compound acetylisovalery tylosin tartrate pellet.The solid content of coating solution is 10%.
Embodiment 2:
A kind of compound acetylisovalery tylosin tartrate pellet, comprise coating and the medicine carrying ball heart, the described medicine carrying ball heart is that size is not more than 30 object micropartical, wherein medicine carrying ball pericardium is containing, for example the component of lower percetage by weight: safe ten thousand rhzomorphs 5% of tartaric acid, sulfadimidine 5%, lactose 15%, maize cob meal 10%, starch 44%, microcrystalline Cellulose 15%, granulation binders 6%.
Wherein, described granulation binders is amylum adhesive.Described coat weight is 3% of described compound acetylisovalery tylosin tartrate pellet gross weight, and wherein coating material is methylcellulose.
The preparation method of described compound acetylisovalery tylosin tartrate pellet, comprises following concrete steps:
1) following each component is weighed respectively by following percentage by weight: tartaric acid safe ten thousand rhzomorphs 5%, sulfadimidine 5%, lactose 15%, maize cob meal 10%, starch 44%, microcrystalline Cellulose 15%, amylum adhesive 6%.By safe for tartaric acid ten thousand rhzomorphs, sulfadimidine, lactose, maize cob meal, starch, microcrystalline Cellulose mix homogeneously;
2) in step 1) gained mixture, add the amylum adhesive prepared and make soft material, via extruding, ball blast obtains the medicine carrying ball heart;
3) by step 2) the gained medicine carrying ball heart carries out drying, screening 30-50 object screening thing after dry;
4) step 3) gained screening thing is put into fluid bed, inlet temperature is 45 DEG C, leaving air temp 35 DEG C, sprays into the coating solution modulated with methylcellulose and carries out Cotton seeds, dry 25 minutes of coated rear continuation, obtains described compound acetylisovalery tylosin tartrate pellet.The solid content of coating solution is 10%.
Embodiment 3:
A kind of compound acetylisovalery tylosin tartrate pellet, comprise coating and the medicine carrying ball heart, the described medicine carrying ball heart is that size is not more than 30 object micropartical, and wherein medicine carrying ball pericardium is containing, for example the component of lower percetage by weight: safe ten thousand rhzomorphs 10% of tartaric acid, sulfadimidine 10%, lactose 10%; Maize cob meal 15%, starch 31%, microcrystalline Cellulose 20%, granulation binders 4%.
Wherein, described granulation binders is the mixture of polyvinyl pyrolidone and Polyethylene Glycol.Described coat weight is 3% of described compound acetylisovalery tylosin tartrate pellet gross weight, and wherein coating material is hydroxypropyl emthylcellulose.
The preparation method of described compound acetylisovalery tylosin tartrate pellet, comprises following concrete steps:
1) following each component is weighed respectively by following percentage by weight: the mixed type granulation binders 4% of tartaric acid safe ten thousand rhzomorphs 10%, sulfadimidine 10%, lactose 10%, maize cob meal 15%, starch 31%, microcrystalline Cellulose 20%, polyvinyl pyrolidone and Polyethylene Glycol.By safe for tartaric acid ten thousand rhzomorphs, sulfadimidine, lactose, maize cob meal, starch, microcrystalline Cellulose mix homogeneously;
2) add in the granulation binders prepared in step 1) gained mixture and make soft material, via extruding, ball blast obtains the medicine carrying ball heart;
3) by step 2) the gained medicine carrying ball heart carries out drying, screening 30-50 object screening thing after dry;
4) step 3) gained screening thing is put into fluid bed, inlet temperature is 55 DEG C, leaving air temp 30 DEG C, sprays into the coating solution modulated with sodium carboxymethyl cellulose and carries out Cotton seeds, dry 20 minutes of coated rear continuation, obtains described compound acetylisovalery tylosin tartrate pellet.The solid content of coating solution is 10%.
Embodiment 4:
A kind of compound acetylisovalery tylosin tartrate pellet, comprise coating and the medicine carrying ball heart, the described medicine carrying ball heart is that size is not more than 30 object micropartical, wherein medicine carrying ball pericardium is containing, for example the component of lower percetage by weight: safe ten thousand rhzomorphs 20% of tartaric acid, sulfadimidine 20%, lactose 5%, maize cob meal 10%, starch 7%, microcrystalline Cellulose 30%, granulation binders 8%.
Wherein, described granulation binders is sodium carboxymethyl cellulose binding agent.Described coat weight is 5% of described compound acetylisovalery tylosin tartrate pellet gross weight, and wherein coating material is hydroxypropyl emthylcellulose.
The preparation method of described compound acetylisovalery tylosin tartrate pellet, comprises following concrete steps:
1) following each component is weighed respectively by following percentage by weight: tartaric acid safe ten thousand rhzomorphs 20%, sulfadimidine 20%, lactose 5%, maize cob meal 10%, starch 7%, microcrystalline Cellulose 30%, sodium carboxymethyl cellulose granulation binders 8%.By safe for tartaric acid ten thousand rhzomorphs, sulfadimidine, lactose, maize cob meal, starch, microcrystalline Cellulose mix homogeneously;
2) add in the granulation binders prepared in step 1) gained mixture and make soft material, via extruding, ball blast obtains the medicine carrying ball heart;
3) by step 2) the gained medicine carrying ball heart carries out drying, screening 30-50 object screening thing after dry;
4) step 3) gained screening thing is put into fluid bed, inlet temperature is 55 DEG C, leaving air temp 35 DEG C, sprays into the coating solution modulated with hydroxyethyl-cellulose and sodium carboxymethyl cellulose and carries out Cotton seeds, dry 25 minutes of coated rear continuation, obtains described compound acetylisovalery tylosin tartrate pellet.The solid content of coating solution is 10%.
Embodiment 5:
A kind of compound acetylisovalery tylosin tartrate pellet, comprise coating and the medicine carrying ball heart, the described medicine carrying ball heart is that size is not more than 30 object micropartical, wherein medicine carrying ball pericardium is containing, for example the component of lower percetage by weight: safe ten thousand rhzomorphs 25% of tartaric acid, sulfadimidine 25%, lactose 5%, maize cob meal 5%, starch 5%, microcrystalline Cellulose 30%, granulation binders 5%.
Wherein, described granulation binders is the mixed type binding agent of hydroxypropyl emthylcellulose and methylcellulose.Described coat weight is 6% of described compound acetylisovalery tylosin tartrate pellet gross weight, and wherein coating material is hydroxypropyl emthylcellulose.
The preparation method of described compound acetylisovalery tylosin tartrate pellet, comprises following concrete steps:
1) following each component is weighed respectively by following percentage by weight: the mixed type granulation binders 5% of tartaric acid safe ten thousand rhzomorphs 25%, sulfadimidine 25%, lactose 5%, maize cob meal 5%, starch 5%, microcrystalline Cellulose 30%, hydroxypropyl emthylcellulose and methylcellulose.By safe for tartaric acid ten thousand rhzomorphs, sulfadimidine, lactose, maize cob meal, starch, microcrystalline Cellulose mix homogeneously;
2) add in the granulation binders prepared in step 1) gained mixture and make soft material, via extruding, ball blast obtains the medicine carrying ball heart;
3) by step 2) the gained medicine carrying ball heart carries out drying, screening 30-50 object screening thing after dry;
4) step 3) gained screening thing is put into fluid bed, inlet temperature is 55 DEG C, leaving air temp 35 DEG C, and the coating solution sprayed into hydroxypropyl emthylcellulose and ethyl vitamin modulate carries out Cotton seeds, dry 30 minutes of coated rear continuation, obtains described compound acetylisovalery tylosin tartrate pellet.The solid content of coating solution is 10%.
The clinical efficacy of compound acetylisovalery tylosin tartrate pellet of the present invention is described below by way of zoopery.
Choose the growing and fattening pigs 80 that Guangdong one large―scale hoggery is substantially identical from numerous autotrophy, feeding and management condition, birth age in days is close, be diagnosed as respiratory tract disease, be divided into 2 groups at random, i.e. experimental group, matched group, often organize 40.Experimental group gives the compound acetylisovalery tylosin tartrate pellet 25g/ ton feed mixing prepared by embodiment 3 application, matched group gives to prepare the safe ten thousand rhzomorph micropills of the tartaric acid prepared with embodiment 3 voluntarily and applies with safe ten thousand rhzomorph pre-mixing agents (carrier is starch) the 40g/ ton feed mixing of common tartaric acid of content, and two groups of feedings and managements are identical.
Outcome measure is cured: symptom after 2 ~ 3 times of offer medicine disappears completely, and cough disappears completely, and the normal person of appetite, body temperature is healing.Effective: to offer medicine after 4 ~ 5 times, spirit, appetite take a turn for the better, and symptom alleviates, and cough obviously alleviates as effectively.Inefficiency: in medication after dead or medication 6 ~ 7 times, symptom does not alleviate or continues to worsen is invalid, calculates accordingly and often fails to respond to any medical treatment in group.
Experimental result: show through clinical observation on the therapeutic effect statistics: the cure rate of experimental group is 87.5% (35/40), effective percentage is 92.5%(37/40), inefficiency 7.5% (3/40), matched group be respectively 70%(28/40), 80%(32/40), 20%(8/40).
Experiment conclusion: the effective percentage of experimental group is higher than matched group by 12.5%, difference extremely significantly (p < 0.01), compound acetylisovalery tylosin tartrate pellet of the present invention embodies than the better clinical effectiveness of common pre-mixing agent and the use amount reducing safe ten thousand rhzomorphs of tartaric acid in treatment porcine respiratory disease as can be seen here, has saved production cost.
For a person skilled in the art, according to technical scheme described above and design, other various corresponding change and distortion can be made, and all these change and distortion all should belong within the protection domain of the claims in the present invention.
Claims (7)
1. a compound acetylisovalery tylosin tartrate pellet, is characterized in that, wraps up the medicine carrying ball heart make by coating material;
1) described medicine carrying ball pericardium draws together the component of following weight percentage: tartaric acid safe ten thousand rhzomorph 1-30%, sulfadimidine 1-30%, lactose 5-20%, maize cob meal 5-25%, starch 10-60%, microcrystalline Cellulose 15-35%, granulation binders 0.5-12%;
2) described coating material weight is no more than 8% of described compound acetylisovalery tylosin tartrate pellet gross weight; Coating material is selected from one or more in hydroxypropyl emthylcellulose, hydroxyethyl-cellulose, sodium carboxymethyl cellulose, methylethylcellulose, Polyethylene Glycol, polyvinylpyrrolidone.
2. compound acetylisovalery tylosin tartrate pellet according to claim 1, is characterized in that: described medicine carrying ball pericardium draws together the component of following weight percentage: the safe ten thousand rhzomorph 5-20% of tartaric acid; Sulfadimidine 5-20%; Lactose 10-15%; Maize cob meal 10-20%; Starch 20-50%; Microcrystalline Cellulose 15-30%; Granulation binders 1-8%.
3. compound acetylisovalery tylosin tartrate pellet according to claim 1 and 2, is characterized in that: the described medicine carrying ball heart is that size is not more than 30 object micropartical.
4. compound acetylisovalery tylosin tartrate pellet according to claim 1 and 2, is characterized in that: described granulation binders is selected from the compositions of one or more in gelatin, polyvinylpyrrolidone, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, methylcellulose, ethyl cellulose or starch slurry.
5. the preparation method of a kind of compound acetylisovalery tylosin tartrate pellet according to claim 1 and 2, is characterized in that carrying out according to the following steps:
1) compositions of one or more in gelatin, polyvinylpyrrolidone, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, methylcellulose, ethyl cellulose or starch is weighed, as granulation binders by formula;
2) weigh safe ten thousand rhzomorphs of tartaric acid, sulfadimidine, lactose, maize cob meal, starch, microcrystalline Cellulose mix homogeneously by formula, then add step 1) gained granulation binders and make soft material, via extruding, ball blast obtains the medicine carrying ball heart;
3) by step 2) the gained medicine carrying ball heart carries out drying, sieves out 30-50 object screening thing after drying;
4) be the coating solution of 10% by previously prepared for the one or more combination thing in hydroxypropyl emthylcellulose, hydroxyethyl-cellulose, sodium carboxymethyl cellulose, methylethylcellulose, Polyethylene Glycol, polyvinylpyrrolidone one-tenth solid content, then step 3) gained screening thing is sprayed in coating solution and carry out Cotton seeds, coated rear continuation is dry, obtains the safe ten thousand rhzomorph micropills of described tartaric acid.
6. the preparation method of compound acetylisovalery tylosin tartrate pellet according to claim 5, is characterized in that: in step 3), the described medicine carrying ball heart is put into fluid bed and carries out drying.
7. the preparation method of compound acetylisovalery tylosin tartrate pellet according to claim 5, it is characterized in that: in step 4), the screening thing sieved is put into fluid bed, and inlet temperature is 40-60 DEG C, spray into coating solution Cotton seeds, the follow-up continuous fluidized drying 15-30 minute of coating.
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| CN107281158A (en) * | 2016-04-12 | 2017-10-24 | 王玉万 | Capsule core material and its micro-capsule containing tylosin are prepared with tylosin anti-stripping agent |
| CN108261410B (en) * | 2016-12-30 | 2020-10-27 | 武汉回盛生物科技股份有限公司 | Tylosin tartrate inclusion enteric-coated preparation and preparation method thereof |
| CN107496436A (en) * | 2017-10-19 | 2017-12-22 | 洛阳瑞华动物保健品有限公司 | A kind of Tylosin Tartrate sulfadimidine sustained release pellet and preparation method thereof |
| CN107753436B (en) * | 2017-10-31 | 2019-10-22 | 成都乾坤动物药业股份有限公司 | A kind of safe ten thousand rhzomorphs pre-mixing agent and the preparation method and application thereof |
| CN114028338B (en) * | 2021-12-28 | 2023-11-03 | 江西英特科胜动保科技有限公司 | Preparation method and application of water-soluble telavancin tartrate premix |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
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| C53 | Correction of patent for invention or patent application | ||
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Inventor after: Liu Xiaoyan Inventor after: Fang Binghu Inventor after: Chen Ruiai Inventor after: Yuan Zhaohong Inventor after: Zhan Suizhang Inventor before: Liu Xiaoyan Inventor before: Fang Fanhu Inventor before: Chen Ruiai Inventor before: Yuan Zhaohong Inventor before: Zhan Suizhang |
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Free format text: CORRECT: INVENTOR; FROM: LIU XIAOYAN FANG FANHU CHEN RUIAI YUAN ZHAOHONG ZHAN HUIZHANG TO: LIU XIAOYAN FANG BINGHU CHEN RUIAI YUAN ZHAOHONG ZHAN HUIZHANG |
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Effective date of registration: 20160617 Address after: 527400 Yunfu City, Xinxing County Province, the new town of North East embankment road, No. 6 Patentee after: GUANGDONG WENS DAHUANONG BIOTECHNOLOGY CO., LTD. Address before: 527400, No. 2, Wen Science Park, east north embankment road, Xinxing County new town, Guangdong, Yunfu, three Patentee before: Guangdong Dahuanong Animal Health Products Co., Ltd. Patentee before: Zhaoqing Dahuanong Biological Pharmaceutical Co., Ltd. |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150422 Termination date: 20190520 |
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| CF01 | Termination of patent right due to non-payment of annual fee |