CN108210371B - Whitening skin-care mask and preparation method thereof - Google Patents
Whitening skin-care mask and preparation method thereof Download PDFInfo
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- CN108210371B CN108210371B CN201810235989.2A CN201810235989A CN108210371B CN 108210371 B CN108210371 B CN 108210371B CN 201810235989 A CN201810235989 A CN 201810235989A CN 108210371 B CN108210371 B CN 108210371B
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- whitening
- mask
- baicalin
- shearing
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- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention discloses a whitening skin-care mask and a preparation method thereof, wherein the mask liquid comprises the following components in percentage by weight: 0.1-10% of neohesperidin dihydrochalcone, 0.1-10% of baicalin, 0.1-5% of daidai pectin, 0.1-2% of dai essential oil, 15-30% of an organic solvent, 800.1-1.0% of tween and the balance of water. In the components of the whitening skin-care mask, the neohesperidin dihydrochalcone and the baicalin are compounded according to the weight percentage, so that the active part of tyrosinase can be damaged, the tyrosinase loses the effect on melanin precursor tyrosine, and the aim of inhibiting melanin formation is fulfilled. In addition, the neohesperidin dihydrochalcone and baicalin can effectively inhibit MMP-1 gene up-regulation caused by infrared rays, so that the premature senility of human skin can be effectively prevented. The preparation method of the whitening skin-care mask has the advantages of easily obtained raw materials, low cost, simple method and easy realization of industrial production.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a whitening skin-care mask and a preparation method thereof.
Background
Skin whitening is one of the traditional aesthetic standards of Chinese females, many females hope to achieve the whitening effect by using a functional whitening skin care product, the whitening product has great market value at home and abroad, but the infrared ray causes the up-regulation of MMP-1 gene in a human body, the MMP-1 is a regulation gene of collagen degrading enzyme, and the degradation of collagen is a main factor of the premature senility of human skin. Meanwhile, the hyperpigmentation of melanin causes skin problems such as spots, freckles, etc., and affects the skin quality of the skin.
The currently accepted process of melanogenesis can be briefly expressed as: tyrosine-dopa-dopaquinone-dopachrome-dihydroxyindole-ketoindole-melanin, the formed melanin is eumelanin or eumelanin, and the skin pigment mainly consists of the eumelanin. Since the formation of melanin occurs mainly in melanocytes, studies on the mechanism of melanin formation in melanocytes have shown that the formation of melanin is mainly due to the inclusion of four enzymes in melanocytes: tyrosinase, dopachrome tautomerase (TRP-2), peroxidase and DI-IICA oxidase (TRP-1), which stabilize tyrosinase activity, which is different from tyrosinase of mice, mushrooms, etc., in human body, and the above four enzymes act individually or synergistically. Inhibition of various melanin-forming enzymes is important if true skin lightening is to be achieved.
Among the various melanin-forming enzymes mentioned above, tyrosinase is a polyphenol oxidase, which belongs to the class of redox enzymes that catalyze mainly two different types of reactions: hydroxylating the monophenol to generate an ortho-dihydroxy compound, and oxidizing the ortho-diphenol to generate ortho-diphenoquinone. In both reactions, oxygen free radicals participate. Tyrosinase is the main rate-limiting enzyme in the process of melanin formation, and the size of the enzyme activity determines the amount of melanin formation. Therefore, the purpose of inhibiting the formation of melanin can be achieved by destroying the active site of tyrosinase.
Disclosure of Invention
The invention provides a whitening skin-care mask and a preparation method thereof, which aim to solve the technical problems of poor skin quality and blackening caused by the formation of melanin in skin, skin senilism and pigmentation caused by infrared rays.
The technical scheme adopted by the invention is as follows:
the whitening skin-care facial mask comprises the following components in percentage by weight: 0.1-10% of neohesperidin dihydrochalcone, 0.1-10% of baicalin, 0.1-5% of daidai pectin, 0.1-2% of dai essential oil, 15-30% of an organic solvent, 800.1-1.0% of tween and the balance of water.
Further, the facial mask liquid comprises the following components in percentage by weight: 0.6-8% of neohesperidin dihydrochalcone, 0.1-5% of baicalin, 0.5-5% of daidai pectin, 0.1-2% of dai essential oil, 15-30% of an organic solvent, 800.1-1.0% of tween and the balance of water.
Furthermore, the whitening skin-care facial mask also comprises mulberry leaf flavone, and the weight percentage of the mulberry leaf flavone is 0.1-5%.
Furthermore, the whitening skin-care facial mask also comprises mulberry leaf flavone, and the weight percentage of the mulberry leaf flavone is 0.1-3%.
Further, the whitening skin-care mask also comprises the following components in percentage by weight: 0.1 to 5 percent of phloretin and 0.1 to 5 percent of lycium barbarum polysaccharide.
Further, the whitening skin-care mask also comprises the following components in percentage by weight: 0.5 to 5 percent of phloretin and 0.1 to 3 percent of lycium barbarum polysaccharide.
Further, the organic solvent is butanediol and glycerol, and the weight percentage of the organic solvent in the mask liquid is 5-10% of butanediol and 10-20% of glycerol respectively.
According to another aspect of the present invention, there is also provided a preparation method of the whitening and skin-care mask, comprising the following steps: placing an organic solvent in a shearing machine, respectively adding tween 80, water and dai pectin during shearing, then adding neohesperidin dihydrochalcone and baicalin, and finally adding dai essential oil to obtain a mask solution, and soaking the mask paper in the mask solution to obtain the whitening and skin-care mask.
The invention has the following beneficial effects:
according to the whitening skin-care mask liquid, the neohesperidin dihydrochalcone and the baicalin are compounded, so that destructive inhibition can be generated on tyrosinase, namely, the active part of the tyrosinase is damaged, the tyrosinase loses the effect on melanin precursor tyrosine, and the purpose of inhibiting melanin formation is achieved. Meanwhile, the neohesperidin dihydrochalcone and baicalin can effectively inhibit MMP-1 gene up-regulation caused by infrared rays, so that the premature senility of human skin can be effectively prevented. In addition, the bitter orange essential oil is added, so that the whitening skin-care mask has a stronger antibacterial effect; the citrus aurantium pectin is an antidote and a prophylactic agent for heavy metals, can reduce the content of heavy metals introduced by air, food and other cosmetics in skin, and can prolong the antibacterial action and the bacteriostatic cycle of citrus aurantium essential oil when combined with the citrus aurantium essential oil; the solubility of the neohesperidin dihydrochalcone and the baicalin in a normal-temperature water solution is limited, the neohesperidin dihydrochalcone and the baicalin are easy to separate out to influence the whitening effect, and the addition of the citrus aurantium pectin can enhance the stability of the whole system and further enhance the whitening effect of the skin-care mask.
The preparation method of the whitening skin-care mask provided by the invention has the advantages of easily obtained raw materials, low cost, simple method and easy realization of industrial production. The traditional preparation method of the facial mask comprises the steps of heating a system to improve the solubility of each component, reducing the temperature of the system, and then subpackaging and blending. The traditional method wastes energy sources, has long preparation period, and can destroy the effective components of each component in the heating process to a certain extent, thereby influencing the whitening effect of the mask. The invention utilizes the high-speed shearing machine to shear and dissolve each component, avoids the heating process of the system, does not damage each component, reduces the energy loss and shortens the preparation period.
In addition to the objects, features and advantages described above, other objects, features and advantages of the present invention are also provided. The present invention will be described in further detail below.
Detailed Description
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail with reference to examples.
The preferred embodiment of the invention provides a whitening and skin-care mask, which comprises the following components in percentage by weight: 0.1-10% of neohesperidin dihydrochalcone, 0.1-10% of baicalin, 0.1-5% of daidai pectin, 0.1-2% of dai essential oil, 15-30% of an organic solvent, 800.1-1.0% of tween and the balance of water.
In the components of the whitening and skin-protecting mask, neohesperidin dihydrochalcone is one of flavonoid compounds derived from plants, and is mainly used as a sweetener in the food industry at present. Researches show that the neohesperidin dihydrochalcone has better effect of inhibiting the neuraminidase than beta-arbutin, kojic acid and VC. Neohesperidin dihydrochalcone is a glycoside flavonoid, and a flavonoid compound is a natural substance extracted from plants. Many flavone glycosides are peculiar to Rutaceae plants, and the synthesis starting material of neohesperidin dihydrochalcone is neohesperidin which is extracted and refined from bitter orange. The literature indicates that the tyrosinase inhibition rate of the neohesperidin dihydrochalcone is the highest compared with the beta-arbutin, VC and kojic acid. The inhibitory capacity of the neohesperidin dihydrochalcone on melanin generation is close to that of VC and kojic acid and is 3 times of that of beta-arbutin, so that the neohesperidin dihydrochalcone is a novel whitening agent with application potential and can be used as a main active ingredient in the development of novel whitening skin care products.
In the components of the whitening skin-care mask, baicalin is a flavonoid compound extracted from astragalus, and the antioxidant activity of scutellaria is proved to be greater than that of vitamin E by an in vitro oxygen radical absorption capacity method, so that the baicalin is a natural strong antioxidant except vitamin E, vitamin C and carotene. The baicalin can inhibit lipid peroxidation of mouse brain cells induced by ascorbic acid and ferrous sulfate, and reduce oxygen consumption of brain nerves stimulated by ADP by using malic acid and glutamic acid as substrates, thereby reducing lipid peroxidation.
Among the components of the whitening skin-care mask, the method for extracting the dai essential oil comprises the steps of extracting the dai essential oil from dai flower, wherein the extraction conditions are that the temperature is 40 ℃, the pressure is 35Mpa, the carbon dioxide flow is 20kg/h, the bulk density of the dai flower is 0.33g/ml, the extract yield is 3.0-3.3%, the extracted dai essential oil is light yellow clear liquid in appearance, and the fragrance is pure. The main active ingredient of daidaidai essential oil is limonene, and pharmacological experiments prove that daidai essential oil is a natural bacteriostatic agent and has a strong antibacterial effect.
In the components of the whitening skin-care mask, the method for extracting citrus aurantium pectin comprises the steps of taking citrus aurantium flavone extraction residues, adding 10 times of pure water, adjusting the pH value to 1.5-2 by using citric acid, extracting for 2 hours at 85 ℃, filtering, concentrating filtrate to 2 times of the extraction residues, adjusting the alcohol content to 55% -60% by using absolute ethyl alcohol, collecting precipitates, drying in vacuum, and crushing to obtain the citrus aurantium pectin, wherein the extracted citrus aurantium pectin is white powder. The citrus aurantium pectin is a purely natural stabilizer and thickener, is also an antidote and a prophylactic agent for heavy metals, can prolong the action of antibiotics, and is matched with citrus aurantium essential oil to obviously enhance the antibacterial capacity and the antibacterial period of the citrus aurantium essential oil.
In the components of the whitening and skin-protecting facial mask, Tween 80 is used as an emulsifier and used as a solubilizer for insoluble components in water in the components of the whitening and skin-protecting facial mask to enhance the solubility of main components.
In the components of the whitening skin-care mask, the neohesperidin dihydrochalcone and the baicalin are compounded according to the weight percentage, so that destructive inhibition can be generated on tyrosinase, namely, the active part of the tyrosinase is damaged, the tyrosinase loses the effect on melanin precursor tyrosine, and the purpose of inhibiting melanin formation is achieved. Meanwhile, the neohesperidin dihydrochalcone and baicalin can effectively inhibit MMP-1 gene up-regulation caused by infrared rays, so that the premature senility of human skin can be effectively prevented. In addition, the bitter orange essential oil is added, so that the whitening skin-care mask has a stronger antibacterial effect; the citrus aurantium pectin is an antidote and a prophylactic agent for heavy metals, can reduce the content of heavy metals introduced by air, food and other cosmetics in skin, and can prolong the antibacterial action and the bacteriostatic cycle of citrus aurantium essential oil when combined with the citrus aurantium essential oil; the solubility of the neohesperidin dihydrochalcone and the baicalin in a normal-temperature water solution is limited, the neohesperidin dihydrochalcone and the baicalin are easy to separate out to influence the whitening effect, and the addition of the citrus aurantium pectin can enhance the stability of the whole system and further enhance the whitening effect of the skin-care mask.
Preferably, the mask solution of the whitening and skin-care mask comprises the following components in percentage by weight: 0.6-8% of neohesperidin dihydrochalcone, 0.1-5% of baicalin, 0.5-5% of daidai pectin, 0.1-2% of dai essential oil, 15-30% of an organic solvent, 800.1-1.0% of tween and the balance of water. More preferably, the mask solution of the whitening and skin-care mask comprises the following components in percentage by weight: 0.6-5% of neohesperidin dihydrochalcone, 0.1-1% of baicalin, 3-5% of daidai pectin, 0.1-2% of dai essential oil, 15-30% of an organic solvent, 800.1-1.0% of tween and the balance of water.
The components in the whitening skin-care mask are compounded according to the preferred weight percentage, so that tyrosinase can be better inhibited, and the formation of melanin is inhibited; in addition, the preferable proportion of the neohesperidin dihydrochalcone and the baicalin can most effectively inhibit the MMP-1 gene up-regulation caused by infrared rays, thereby generating better inhibiting effect on the skin premature senility of human bodies; the optimal proportion of daidai essential oil and dai pectin enables the antibacterial effect of the skin care mask to be strongest, and the stability of each component in the system to be enhanced to the maximum extent, so that the whitening effect is optimal.
Preferably, the whitening skin-care mask also comprises mulberry leaf flavone, and the weight percentage of the mulberry leaf flavone is 0.1-5%. More preferably, the weight percentage is 0.1-3%. More preferably, the weight percentage is 0.1 to 1 percent.
In the components of the whitening skin-care mask, the mulberry leaf flavone is a flavonoid compound extracted from mulberry, and can achieve antioxidant activity by improving SOD activity, reducing LPO content and changing GSH-PX level. The compounding of the mulberry leaf flavone, the neohesperidin dihydrochalcone and the baicalin can enhance the capability of destroying the active site of tyrosinase, so that the tyrosinase loses the effect on melanin precursor tyrosine and is enhanced, and the whitening effect of the whitening and skin-protecting mask is enhanced.
Preferably, the whitening and skin-care facial mask further comprises the following components in percentage by weight: 0.1 to 5 percent of phloretin and 0.1 to 5 percent of lycium barbarum polysaccharide. Preferably, the whitening and skin-care facial mask further comprises the following components in percentage by weight: 0.5 to 5 percent of phloretin and 0.1 to 3 percent of lycium barbarum polysaccharide. More preferably, the whitening and skin-care facial mask further comprises the following components in percentage by weight: phloretin 1-5 wt% and wolfberry fruit polysaccharide 0.1-1 wt%.
In the components of the whitening skin-care mask, phloretin is an aglycone part of phlorizin and is separated from the phlorizin by adding acid and hydrolyzing; or synthesized by corresponding chemical processes. Phloretin can inhibit excessive secretion of sebaceous gland, and can be used for treating acne with excessive secretion; can inhibit activity of melanocyte, and has strong effect in eliminating various skin color spots.
In the components of the whitening skin-care mask, the lycium barbarum polysaccharide is a polysaccharide compound extracted from lycium barbarum. Epidemiological data prove that the occurrence and development of skin diseases such as acne, atopic dermatitis, polymorphous light eruption, scleroderma, epidermal tumor and the like are all related to oxidative stress injury, and lycium barbarum polysaccharide can relieve the oxidative stress injury of cells through an antioxidant mechanism, maintain the dynamic balance of skin oxidation and antioxidant to repair and protect the cells.
In the components of the whitening skin-care mask, when the phloretin, the lycium barbarum polysaccharide and the mulberry flavone are compounded, the purpose of inhibiting the formation of melanin can be achieved by inhibiting the biosynthesis of tyrosinase or substituting the action substrate of the tyrosinase. And the five components are combined for use by compounding with neohesperidin dihydrochalcone and baicalin, so that the source of melanin generation is thoroughly cut off, and the effect of whitening skin is achieved.
Preferably, the organic solvent is butanediol and glycerol, and the weight percentage of the organic solvent in the mask liquid is 5-10% of butanediol and 10-20% of glycerol respectively. The organic solvent is beneficial to fully dissolving each component in the whitening and skin-care facial mask so as to exert the synergistic effect of each component, and the organic solvent has good moisturizing effect and good solubility to the main component.
Preferably, the water used in the whitening and skin-care mask is deionized water, and more preferably secondary purified water.
According to another aspect of the present invention, there is also provided a method for preparing the whitening and skin-care mask, comprising the steps of: placing an organic solvent in a shearing machine, respectively adding tween 80, water and dai pectin during shearing, then adding neohesperidin dihydrochalcone and baicalin, and finally adding dai essential oil to obtain a mask solution, and placing a mask paper in the mask solution for soaking to obtain the whitening and skin-care mask. When the facial mask liquid also comprises mulberry leaf flavone, phloretin and lycium barbarum polysaccharide components, the mulberry leaf flavone, phloretin and lycium barbarum polysaccharide components are added together with neohesperidin dihydrochalcone and baicalin and then are sheared.
The preparation method of the whitening skin-care mask has the advantages of easily obtained raw materials, low cost, simple method and easy realization of industrial production. The traditional preparation method of the facial mask comprises the steps of heating a system to improve the solubility of each component, reducing the temperature of the system, and then subpackaging and blending. The traditional method wastes energy sources, has long preparation period, and can destroy the effective components of each component in the heating process to a certain extent, thereby influencing the whitening effect of the mask. The invention utilizes the high-speed shearing machine to shear and dissolve each component, avoids the heating process of the system, does not damage each component, reduces the energy loss and shortens the preparation period.
Examples
The chemicals are commercially available in the following examples.
Example 1
The whitening skin-care facial mask comprises the following components in percentage by weight: neohesperidin dihydrochalcone 2%, baicalin 1%, mulberry flavone 0.5%, phloretin 3%, lycium barbarum polysaccharide 0.5%, butanediol 5%, glycerol 10%, citrus aurantium pectin 5%, citrus aurantium essential oil 1%, tween 801.0% and secondary purified water 71%.
The preparation method of the whitening skin-care mask comprises the following steps: placing butanediol and glycerol into a high-speed shearing machine for shearing at the shearing speed of 15000 r/min, slowly adding Tween 80 in the shearing process, shearing at normal temperature for 10min, slowly adding secondary purified water, shearing at normal temperature for 10min, slowly adding citrus aurantium pectin, shearing at normal temperature for 10min, then adding neohesperidin dihydrochalcone, baicalin, mulberry leaf flavone, phloretin and lycium barbarum polysaccharide, shearing at normal temperature for 20min, dissolving, finally adding citrus aurantium essential oil, shearing for 10min to obtain a mask liquid, placing the mask paper into the packaged mask liquid, soaking, and sealing to obtain the whitening and skin-protecting mask.
The human skin fibroblasts were taken and tested for the inhibition of MMP-1 gene up-regulation after infrared irradiation of the 5 main ingredients in the above-described whitening and skin-care facial mask and the composition formulated in example 1 using a Hydrosun 500H IRA apparatus. The treatment of the 5 main components is as follows:
baicalin: diluting baicalin dissolved in DMSO at 44.8mmol/ml to 10umol/ml and 25umol/ml respectively;
phloretin: diluting phloretin 50mmol/ml dissolved in DMSO to 1umol/ml, 5umol/ml, 10umol/ml respectively;
and (3) mulberry leaf flavone: diluting folium Mori flavone 50mmol/ml dissolved in DMSO to 5umol/ml and 10umol/ml respectively;
wolfberry polysaccharide: diluting 50mmol/ml Lycium barbarum polysaccharides dissolved in DMSO to 5umol/ml and 10umol/ml respectively;
neohesperidin dihydrochalcone: 710mmol/ml neohesperidin dihydrochalcone dissolved in DMSO is respectively diluted to 100umol/ml, 500umol/ml and 1 mmol/ml.
Composition proportioned in example 1: 50mmol/ml of the composition dissolved in DMSO was diluted to 5. mu. mol/ml and 10. mu. mol/ml, respectively.
Before testing, human skin fibroblasts were incubated for 24h at the indicated concentrations of each of the above ingredients, followed by 360J/cm2And the infrared ray is irradiated for 24 hours, and the infrared ray is proved to be capable of inducing gene expression without damaging the cell function. Subsequently, RNA was extracted and MMP-1mRNA was analyzed. The analysis results are shown in table 1. As is clear from the analysis data in Table 1, the compositions of 5 main components and the composition prepared in example 1 were able to inhibit the infrared light-induced MMP-1 gene up-regulation.
TABLE 15 inhibition of MMP-1 gene up-regulation by compositions of the major ingredients and the ratios of examples 1-5
Example 2
The whitening skin-care facial mask comprises the following components in percentage by weight: 8% of neohesperidin dihydrochalcone, 5% of baicalin, 0.1% of mulberry leaf flavone, 0.1% of phloretin, 0.1% of lycium barbarum polysaccharide, 5% of butanediol, 15% of glycerol, 5% of daidaidai pectin, 1% of dai essential oil, 801.0% of tween and 59.7% of secondary purified water.
The preparation method of the whitening and skin-care mask is the same as that of the embodiment 1.
The inhibition effect of the composition prepared in example 2 on the up-regulation of MMP-1 gene after infrared light irradiation is shown in Table 1.
Example 3
The whitening skin-care facial mask comprises the following components in percentage by weight: neohesperidin dihydrochalcone 2%, baicalin 1%, mulberry flavone 5%, phloretin 5%, lycium barbarum polysaccharide 5%, butanediol 8%, glycerol 12%, daidaidai pectin 5%, daidai essential oil 2%, tween 801.0% and secondary purified water 54%.
The preparation method of the whitening and skin-care mask is the same as that of the embodiment 1.
The inhibition effect of the composition prepared in example 3 on the up-regulation of MMP-1 gene after infrared light irradiation is shown in Table 1.
Example 4
The whitening skin-care facial mask comprises the following components in percentage by weight: 8% of neohesperidin dihydrochalcone, 5% of baicalin, 3% of mulberry leaf flavone, 5% of phloretin, 3% of lycium barbarum polysaccharide, 10% of butanediol, 15% of glycerol, 5% of daidaidai pectin, 2% of daidaidai essential oil, 801.0% of tween and 43% of secondary purified water.
The preparation method of the whitening and skin-care mask is the same as that of the embodiment 1.
The inhibition effect of the composition prepared in example 4 on the up-regulation of MMP-1 gene after infrared light irradiation is shown in Table 1.
Example 5
The whitening skin-care facial mask comprises the following components in percentage by weight: 10% of neohesperidin dihydrochalcone, 10% of baicalin, 5% of mulberry leaf flavone, 5% of phloretin, 5% of lycium barbarum polysaccharide, 10% of butanediol, 20% of glycerol, 5% of daidaidai pectin, 2% of daidaidai essential oil, 801.0% of tween and 27% of secondary purified water.
The preparation method of the whitening and skin-care mask is the same as that of the embodiment 1.
The inhibition effect of the composition prepared in example 5 on the up-regulation of MMP-1 gene after infrared light irradiation is shown in Table 1.
In order to verify the whitening effect of the product, the following comparative test formula is carried out for a comparative experiment:
formula 1: the mulberry leaf flavone, phloretin and lycium barbarum polysaccharide are respectively replaced by the same amount of second-level purified water, and the composition and preparation method of other components are the same as those in example 1.
And (2) formula: neohesperidin dihydrochalcone and baicalin were replaced with the same amount of second-stage purified water, and the composition and preparation method of the other components were the same as those in example 1.
And (3) formula: the composition and preparation of all components are the same as in example 1.
Volunteers: randomly selecting 30 healthy male and female volunteers, wherein the male and female volunteers are 18-65 years old, have no serious system diseases, no immune defects or autoimmune diseases, have no allergic diseases, do not use various cosmetics and the like during a test period, and can finish the use of specified samples according to experimental requirements. The experimental method comprises the following steps: the volunteers are divided into 3 groups according to the formula, 10 persons are in each group, the 3 groups of the formula are subjected to a trial test on the volunteers for 28 days, the volunteers are used for 1 time every other night, and the trial part is the face. Testing an instrument: a skin elasticity CotometerMPA580 host manufactured by CK company, germany; skin melanin mexamettmx 18 test probe manufactured by CK company, germany. Face test conditions: the face test was performed indoors with no intense sunlight or direct lighting. Whitening products (including other cosmetics, external medicines or internal health care products) cannot be used 2-3 days before the test. The subjects required a uniform cleansing of facial skin and a clean wipe with dry tissue prior to testing.
Based on the principle of spectral absorption, the content of melanin in the skin is determined by measuring the reflection amount of light with a specific wavelength irradiated on the skin of a human body. The test probe of the pigment detector consists of a light source emitter and a light source receiver, and a spring is additionally arranged to keep the pressure on the skin constant during detection. The transmitter of the probe emits light with three wavelengths of 568nm, 660nm and 880nm to the surface of the skin, and the receiver measures the light reflected by the skin. Since the amount of emitted light is constant, the amount of light absorbed by the skin can be measured, and the amount of melanin in the skin can be measured. The data in table 2 are the skin melanin content determined.
TABLE 2 comparison of melanin content (%)
The data from the 3 formulations above were subjected to paired T-test using span 17.0, with the following results:
formula 1:
paired sample statistics
Correlation coefficient of paired samples
Paired sample testing
From the above data, it can be seen that the mean value of skin melanin content of the volunteers after the 28-day test period of formula 1 decreased by 10.7, and the skin whitening tendency was significant (P < 0.05).
And (2) formula:
paired sample statistics
Correlation coefficient of paired samples
Paired sample testing
From the above data, it can be seen that the mean value of skin melanin content of the volunteers after the 28-day test period of formula 2 decreased by 9.6, and the skin whitening trend was significant (P < 0.05).
And (3) formula:
paired sample statistics
Correlation coefficient of paired samples
Paired sample testing
From the above data, it can be seen that the mean value of skin melanin content of volunteers after the 28-day test period of formula 3 decreased by 18.1, and the skin whitening trend was significant (P < 0.05).
The above experimental results show that the skin melanin content of the volunteers is reduced after the test period of 28 days by the 3 test formulas, and the skin whitening trend is obvious, wherein the skin melanin content of the volunteers is reduced most obviously after the test period of 28 days by the formula 3, and the effect is obviously better than that of the former two groups of formulas. Consumer tests show that the whitening skin care mask has an obvious effect on whitening skin by combining 5 main components of neohesperidin dihydrochalcone, baicalin, mulberry leaf flavone, phloretin and lycium barbarum polysaccharide, and the whitening effect is superior to that of a formula in which neohesperidin dihydrochalcone and baicalin are singly combined or a formula in which mulberry leaf flavone, phloretin and lycium barbarum polysaccharide are singly combined.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (1)
1. The whitening skin-care mask is characterized by comprising the following components in percentage by weight:
8% of neohesperidin dihydrochalcone, 5% of baicalin, 3% of mulberry leaf flavone, 5% of phloretin, 3% of lycium barbarum polysaccharide, 10% of butanediol, 15% of glycerol, 5% of daidaidai pectin, 2% of daidaidai essential oil, 801.0% of tween and 43% of secondary purified water;
the preparation method of the whitening skin-care mask comprises the following steps:
placing butanediol and glycerol into a high-speed shearing machine for shearing, wherein the shearing speed is 15000 r/min, slowly adding Tween 80 in the shearing process, shearing for 10min at normal temperature, slowly adding secondary purified water, shearing for 10min at normal temperature, slowly adding citrus aurantium pectin, shearing for 10min at normal temperature, then adding neohesperidin dihydrochalcone, baicalin, mulberry leaf flavone, phloretin and lycium barbarum polysaccharide, shearing for 20min at normal temperature, dissolving, finally adding citrus aurantium essential oil, shearing for 10min, obtaining a mask solution, placing the mask paper into the packaged mask solution, soaking, and sealing to obtain the whitening and skin-care mask.
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| US20140045777A1 (en) * | 2012-08-13 | 2014-02-13 | L'oreal S.A. | Method of inhibiting premature aging of human skin caused by exposure to infrared radiation |
| US20150005247A1 (en) * | 2013-07-01 | 2015-01-01 | L'oreal | Compositions containing at least two phenolic compounds, a lipid-soluble antioxidant and at least one hydrotrope for cosmetic use |
| WO2017058594A1 (en) * | 2015-10-01 | 2017-04-06 | Senomyx, Inc. | Compounds useful as modulators of trpm8 |
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| CN102525853B (en) * | 2011-12-23 | 2013-06-05 | 广州市娇兰化妆品有限公司 | Compound natural plant extract with spot-removing function and preparation method and application thereof |
| CN103340795A (en) * | 2013-07-05 | 2013-10-09 | 上海珍馨化工科技有限公司 | Radix scutellariae toner |
| CN103845235A (en) * | 2014-02-13 | 2014-06-11 | 上海珍馨化工科技有限公司 | Whitening cosmetic |
| CN104490617B (en) * | 2014-11-24 | 2017-06-16 | 佛山市金骏康健康科技有限公司 | Dihydrochalcone glucosides is used as whitening, the purposes of the dark and gloomy skin quality active ingredient of improvement |
| CN105943433A (en) * | 2016-05-11 | 2016-09-21 | 杭州西顿生物科技有限公司 | Skin-whitening composition as well as preparation method and applications thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140045777A1 (en) * | 2012-08-13 | 2014-02-13 | L'oreal S.A. | Method of inhibiting premature aging of human skin caused by exposure to infrared radiation |
| US20150005247A1 (en) * | 2013-07-01 | 2015-01-01 | L'oreal | Compositions containing at least two phenolic compounds, a lipid-soluble antioxidant and at least one hydrotrope for cosmetic use |
| WO2017058594A1 (en) * | 2015-10-01 | 2017-04-06 | Senomyx, Inc. | Compounds useful as modulators of trpm8 |
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Address after: 417100 Loudi hi tech Industrial Development Zone, Loudi City, Hunan Province Patentee after: LIANYUAN KANGBIOTECH CO.,LTD. Patentee after: Lianyuan Kangcheng Agriculture and Forestry Technology Development Co.,Ltd. Address before: 417100 Loudi hi tech Industrial Development Zone, Loudi City, Hunan Province Patentee before: LIANYUAN KANGBIOTECH CO.,LTD. Patentee before: Lianyuan Kangcheng Agricultural Technology Development Co.,Ltd. |