KR102356144B1 - Cosmetic composition and health functional food for skin whitening and anti-wrinkle - Google Patents
Cosmetic composition and health functional food for skin whitening and anti-wrinkle Download PDFInfo
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- KR102356144B1 KR102356144B1 KR1020210076709A KR20210076709A KR102356144B1 KR 102356144 B1 KR102356144 B1 KR 102356144B1 KR 1020210076709 A KR1020210076709 A KR 1020210076709A KR 20210076709 A KR20210076709 A KR 20210076709A KR 102356144 B1 KR102356144 B1 KR 102356144B1
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- powder
- pomegranate
- skin
- lotion
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
Description
본 발명은 석류 발효 분말을 유효성분으로 함유하는 피부 미백 및 주름 개선용 건강기능식품 및 화장료 조성물에 관한 것이다.The present invention relates to a health functional food and cosmetic composition for skin whitening and wrinkle improvement containing fermented pomegranate powder as an active ingredient.
피부는 신체조직 중 직접적으로 외부환경에 노출되어 있으며, 인체의 내부와 외부환경 사이의 방어벽 역할을 하여 화학물질이나 자외선을 포함한 외부 환경오염 물질 및 미생물의 침입을 방어함으로써 주위환경으로부터 생체를 보호한다. 또한 피부는 멜라닌, 헤모글로빈(hemoglobin), 카로틴(carotene) 등에 의해 색이 결정되는데 이 중에서도 멜라닌이 가장 중요한 역할을 한다. 멜라닌은 사람의 피부색을 결정하는 것 이외에도 자외선 흡수 작용, 자유 라디칼 소거제(free radical scavenger) 등과 같은 피부 보호 작용을 수행한다. 그러나 자외선의 과다노출, 대기 오염, 스트레스 등과 같은 외부의 환경 변화에 의하여 멜라닌이 과다하게 생성되면 피부 내에서 색소 침착 현상을 일으켜 피부의 흑화(melanism) 또는 기미, 주근깨 등의 원인이 된다. 피부의 흑화는 내적 및 외적 요인에 대한 피부 세포의 반응에 의하여 발생하는 것으로, 대표적인 요인은 자외선 노출로 인한 것이다. 즉, 피부가 자외선에 노출되면 티로시나아제(tyrosinase)가 활성화되는데, 상기 티로시나아제가 피부조직에 존재하는 티로신에 작용하여 도파(DOPA) 및 도파퀴논(dopaquinone)을 생성시키는 산화 과정에 의하여, 피부 색소 세포인 멜라노사이트(melanocyte) 내의 멜라노좀(melanosome)에서 멜라닌이라는 중합체가 합성되며, 이러한 멜라닌이 피부의 각질 형성 세포인 케라티노사이트(keratinocyte)로 전달되고 각질화 과정에 의해 피부 표면에 도달하여 자외선으로부터 피부를 보호하게 된다. 따라서, 멜라닌은 우리 인체에 없어서는 안되는 자외선 방어제이며, 또한 단백질, 지질, 핵산 등과 같은 생체성분을 변형시키는 다양한 라디칼을 제거하는 효과적인 자유 라디칼 소거제의 역할을 담당하고 있다. 그러나 멜라닌이 국소적으로 과도하게 합성되거나, 피부 병변 및 노화에 따른 피부의 생리 기능이 떨어지게 되면, 멜라닌이 피부 표면에 침착되어 기미, 주근깨 및 다양한 색소 침착을 유발하게 된다. 상기한 바와 같이 피부 흑화의 원인과 기작이 밝혀지면서, 미백 화장료의 제조에 있어 피부 흑화 과정에 관여하는 효소인 티로시나아제의 활성 저해 효과를 갖는 물질들을 화장료에 배합하거나, 또는 멜라닌 생성과정 중에서 일부 반응을 저해함으로써 멜라닌의 생성을 감소시키는 방법이 일반적으로 사용되고 있다. 이러한 목적을 위해 사용되고 있는 대표적인 물질로는 아스코르브산(ascorbic acid), 코지산(kojic acid), 하이드로퀴논(hydroquinone) 등의 화학 물질과 상백피 추출물, 감초 추출물 등의 식물 추출물이 있다. 하지만, 아스코르브산은 티로시나아제 활성 저해 효과가 부족할 뿐만 아니라 분자 자체의 안정성이 낮아서 멜라닌 생성 억제제로 적합하지 않으며, 코지산은 티로시나아제의 저해활성이 우수하지만, 화장료에 배합할 때 변색되고 경시 변화에 따라서 역가가 저하되는 등의 안정성에 문제가 있을 뿐만 아니라, 피부 자극이 커서 사용상 한계가 있고, 하이드로퀴논은 피부 자극 및 안전성 문제로 인하여 화장료에서의 사용이 제한되고 있다. 따라서, 신규하고 효과적인 미백 성분의 개발에 대한 관심이 집중되고 있다.The skin is directly exposed to the external environment among body tissues, and acts as a barrier between the internal and external environments of the human body to protect the living body from the surrounding environment by preventing the intrusion of external environmental pollutants and microorganisms including chemicals and ultraviolet rays. . In addition, the skin color is determined by melanin, hemoglobin, carotene, etc. Among them, melanin plays the most important role. In addition to determining the color of a person's skin, melanin also performs skin protection functions such as UV absorption and free radical scavengers. However, when melanin is excessively generated by external environmental changes such as overexposure to ultraviolet rays, air pollution, stress, etc., it causes pigmentation in the skin, which causes skin blackening or melasma, freckles, and the like. Blackening of the skin is caused by the reaction of skin cells to internal and external factors, and a representative factor is due to UV exposure. That is, when the skin is exposed to ultraviolet light, tyrosinase is activated, and the tyrosinase acts on tyrosine present in the skin tissue to produce dopa (DOPA) and dopaquinone (dopaquinone) by an oxidation process, A polymer called melanin is synthesized in melanosomes in melanocytes, which are skin pigment cells, and this melanin is transferred to keratinocytes, which are keratinocytes of the skin, and reaches the skin surface through the keratinization process. It protects the skin from UV rays. Therefore, melanin is an essential UV protection agent for our human body, and also plays the role of an effective free radical scavenger that removes various radicals that modify biocomponents such as proteins, lipids, and nucleic acids. However, when melanin is locally synthesized excessively or the physiological function of the skin is deteriorated due to skin lesions and aging, melanin is deposited on the skin surface, causing melasma, freckles and various pigmentation. As described above, as the cause and mechanism of skin blackening have been revealed, substances having an inhibitory effect on the activity of tyrosinase, an enzyme involved in the skin blackening process in the manufacture of whitening cosmetics, are mixed in cosmetics, or some of the melanin production process A method of reducing the production of melanin by inhibiting the reaction is generally used. Representative materials used for this purpose include chemical substances such as ascorbic acid, kojic acid, and hydroquinone, and plant extracts such as epiphysis extract and licorice extract. However, ascorbic acid lacks tyrosinase activity inhibitory effect and has low molecular stability, so it is not suitable as a melanogenesis inhibitor. Therefore, there is a problem in stability such as a decrease in potency, and there is a limitation in use due to large skin irritation, and hydroquinone is limited in use in cosmetics due to skin irritation and safety problems. Therefore, attention is focused on the development of novel and effective whitening ingredients.
석류(Punica granatum L., Pomegranate)는 석류과(Punicaceae)에 속하는 낙엽성 소목의 열매로 이란을 중심으로 아열대 및 열대 각지에 널리 퍼져 있는 식물이다. 예부터 촌충의 구제, 설사, 이질, 구내염, 장출혈에 효과가 있는 것으로 알려져, 석류열매와 줄기껍질, 그리고 뿌리껍질을 건조하여 한약재로 많이 쓰여 왔으며, 근래에는 고혈압과 동맥경화, 항산화, 항염증, 항암 등의 임상적 효능을 가진 90여 종의 생리활성물질이 함유되어 있는 것으로 보고되어 있다. 석류의 주요 성분은 알칼로이드인 이소펠레티에린(isopelletierine)이며, 그 외 타닌인 퓨니칼린(punicalin), 이눌린(inuline), 만니톨(mannitol), 소르비톨(sorbitol), 말산(malic acid) 등이 함유되어 있다. 석류나무의 수피, 잎, 과피에는 에라지타닌(ellagitannin)과 갈로타닌(gallotanin)이 풍부하고, 잎에는 아피게닌(apigenin), 루테인(lutein) 등의 배당체가 함유되어 있다. 또한, 석류는 과즙보다 껍질과 씨부분에 기능성 성분의 함량뿐만 아니라, 항암 및 항산화 활성이 높으며, 여성호르몬인 에스트로겐 대응 물질도 많이 포함되어 있는 것으로 밝혀졌다. 최근 석류씨 중의 푸닉산(punicic acid), 에스트로겐(estrogen), 에스트라디올(estradiol), β-시토스테롤(β-sitosterol)의 생리활성 및 섭취 효과가 보고되면서 석류씨에 대한 많은 연구들이 발표되고 있다. 석류나 콩과류에서 발견되는 피토에스트로겐(phytoestrogen)의 주성분은 이소플라본과 리그난 등의 페놀성 화합물이며, 이들 페놀성 화합물은 천연의 성호르몬과 공통성을 갖는 구조를 가지고 있어 암, 심장혈관질환, 골다공증 등의 만성질환에 대해서 예방 효과가 있다고 보고되고 있다.Pomegranate ( Punica granatum L., Pomegranate) is a fruit of a deciduous tree belonging to the pomegranate family (Punicaceae). It has been known to be effective in the control of tapeworms, diarrhea, dysentery, stomatitis, and intestinal bleeding since ancient times, and the dried pomegranate fruit, stem peel, and root bark have been widely used as herbal medicines. It is reported that it contains about 90 kinds of physiologically active substances with clinical efficacy such as anticancer. The main component of pomegranate is isopelletierine, an alkaloid, and other tannins such as punicalin, inuline, mannitol, sorbitol, and malic acid are contained. have. The bark, leaves, and rinds of pomegranate trees are rich in ellagitannin and gallotannin, and the leaves contain glycosides such as apigenin and lutein. In addition, it was found that pomegranate not only has a higher content of functional ingredients in the skin and seeds than fruit juice, but also has high anticancer and antioxidant activity, and contains a lot of substances corresponding to estrogen, a female hormone. Recently, as the physiological activities and intake effects of punicic acid, estrogen, estradiol, and β-sitosterol in pomegranate seeds have been reported, many studies on pomegranate seeds have been published. The main components of phytoestrogen found in pomegranates and legumes are phenolic compounds such as isoflavones and lignans. It is reported to be effective in preventing chronic diseases such as osteoporosis.
한국공개특허 제2011-0038547호에는 피부진정 효과를 갖는 석류 추출물을 함유하는 화장료 조성물이 개시되어 있고, 한국공개특허 제2003-0025067호에는 석류 추출물을 함유하는 화장료 조성물이 개시되어 있으나, 본 발명의 석류 발효 분말을 유효성분으로 함유하는 피부 미백 및 주름 개선용 조성물과는 상이하다.Korea Patent Publication No. 2011-0038547 discloses a cosmetic composition containing a pomegranate extract having a skin soothing effect, and Korea Patent Publication No. 2003-0025067 discloses a cosmetic composition containing a pomegranate extract. It is different from the composition for skin whitening and wrinkle improvement containing pomegranate fermented powder as an active ingredient.
본 발명은 상기와 같은 요구에 의해 안출된 것으로서, 본 발명의 목적은 석류 발효 분말을 유효성분으로 함유하는 피부 미백 및 주름 개선용 건강기능식품 및 화장료 조성물을 제공하고, 본 발명의 유효성분인 석류 발효 분말이 세포 독성이 없으며, 멜라닌 생성 저해 활성 및 엘라스타아제 저해 활성이 현저한 것을 확인함으로써, 본 발명을 완성하였다.The present invention has been devised in response to the above needs, and an object of the present invention is to provide a health functional food and cosmetic composition for skin whitening and wrinkle improvement containing fermented pomegranate powder as an active ingredient, and pomegranate as an active ingredient of the present invention By confirming that the fermented powder has no cytotoxicity, melanin production inhibitory activity and elastase inhibitory activity are remarkable, the present invention has been completed.
상기 과제를 해결하기 위해, 본 발명은 석류 발효 분말을 유효성분으로 함유하는 피부 미백 및 주름 개선용 건강기능식품 조성물을 제공한다.In order to solve the above problems, the present invention provides a health functional food composition for skin whitening and wrinkle improvement containing fermented pomegranate powder as an active ingredient.
또한, 본 발명은 석류 발효 분말을 유효성분으로 함유하는 피부 미백 및 주름 개선용 화장료 조성물을 제공한다.In addition, the present invention provides a cosmetic composition for skin whitening and wrinkle improvement containing fermented pomegranate powder as an active ingredient.
본 발명의 석류 발효 분말은 피부 미백 및 피부 주름 개선 효과가 우수하여, 피부 미백 및 피부 주름 개선을 위한 화장료 및 건강기능식품 등이 유용하게 사용될 수 있다.The fermented pomegranate powder of the present invention has excellent skin whitening and skin wrinkle improvement effects, and thus cosmetics and health functional foods for skin whitening and skin wrinkle improvement can be usefully used.
본 발명의 목적을 달성하기 위하여, 본 발명은 석류, 곰취 분말, 나한과 분말 및 물을 혼합한 혼합물에 표고버섯 균사체를 혼합하여 배양한 배양물을 건조한 후 분쇄한 석류 발효 분말을 유효성분으로 함유하는 피부 미백 및 주름 개선용 건강기능식품 조성물을 제공한다.In order to achieve the object of the present invention, the present invention contains pomegranate fermented powder, which is pulverized after drying a culture by mixing shiitake mushroom mycelium in a mixture of pomegranate, gomchi powder, ragweed powder and water, as an active ingredient. It provides a health functional food composition for skin whitening and wrinkle improvement.
본 발명의 건강기능식품 조성물에서, 상기 혼합물은 바람직하게는 석류 63~67 중량%, 곰취 분말 8~12 중량%, 나한과 분말 8~12 중량% 및 물 13~17 중량%를 혼합한 혼합물일 수 있으며, 더욱 바람직하게는 석류 65 중량%, 곰취 분말 10 중량%, 나한과 분말 10 중량% 및 물 15 중량%를 혼합한 혼합물일 수 있으나, 이에 제한되지 않는다.In the health functional food composition of the present invention, the mixture is preferably a mixture of 63 to 67% by weight of pomegranate, 8 to 12% by weight of gomchi powder, 8 to 12% by weight of Nahanwa powder and 13 to 17% by weight of water More preferably, it may be a mixture of 65% by weight of pomegranate, 10% by weight of gomchwi powder, 10% by weight of Nahan and powder, and 15% by weight of water, but is not limited thereto.
또한, 본 발명의 건강기능식품 조성물에서, 상기 석류 발효 분말은 바람직하게는 석류 63~67 중량%, 곰취 분말 8~12 중량%, 나한과 분말 8~12 중량% 및 물 13~17 중량%를 혼합한 혼합물에 표고버섯 균사체를 혼합하여 20~30℃에서 12~16일 동안 배양한 배양물을 건조한 후 분쇄하여 제조된 것일 수 있으며, 더욱 바람직하게는 석류 65 중량%, 곰취 분말 10 중량%, 나한과 분말 10 중량% 및 물 15 중량%를 혼합한 혼합물에 표고버섯 균사체를 혼합하여 25℃에서 14일 동안 배양한 배양물을 건조한 후 분쇄하여 제조된 것일 수 있으나, 이에 제한되지 않는다.In addition, in the health functional food composition of the present invention, the fermented pomegranate powder is preferably 63 to 67% by weight of pomegranate, 8 to 12% by weight of gomchi powder, 8 to 12% by weight of Nahanwa powder and 13 to 17% by weight of water. It may be prepared by mixing shiitake mushroom mycelium in the mixed mixture and drying and pulverizing a culture cultured for 12 to 16 days at 20 to 30 ° C. More preferably, 65 wt% of pomegranate, 10 wt% of gomchi powder, It may be prepared by mixing shiitake mushroom mycelium in a mixture of Nahan, 10% by weight of powder and 15% by weight of water, and drying and pulverizing a culture cultured at 25°C for 14 days, but is not limited thereto.
또한, 본 발명의 건강기능식품 조성물에서, 상기 조성물은 분말, 과립, 환, 정제, 캡슐, 캔디, 시럽 및 음료 중에서 선택된 어느 하나의 제형으로 제조되는 것일 수 있으나, 이에 제한되지 않는다.In addition, in the health functional food composition of the present invention, the composition may be prepared in any one formulation selected from powder, granule, pill, tablet, capsule, candy, syrup and beverage, but is not limited thereto.
본 발명의 건강기능식품 조성물을 식품첨가물로 사용하는 경우, 상기 건강기능식품 조성물을 그대로 첨가하거나 다른 식품 또는 식품성분과 함께 사용될 수 있고, 통상적인 방법에 따라 적절하게 사용될 수 있다. 유효성분은 그의 사용 목적에 따라 적절하게 사용될 수 있다. 일반적으로, 식품 또는 음료의 제조시 본 발명의 건강기능식품 조성물은 원료에 대하여 50 중량부 이하, 바람직하게는 35 중량부 이하의 양으로 첨가된다. 그러나 건강을 목적으로 하는 장기간의 섭취의 경우에는 상기 양은 상기 범위 이하일 수 있으며, 안전성 면에서 아무런 문제가 없기 때문에 유효성분은 상기 범위 이상의 양으로 사용될 수 있다.When the health functional food composition of the present invention is used as a food additive, the health functional food composition may be added as it is or used together with other foods or food ingredients, and may be appropriately used according to a conventional method. The active ingredient may be appropriately used depending on the purpose of its use. In general, in the production of food or beverage, the health functional food composition of the present invention is added in an amount of 50 parts by weight or less, preferably 35 parts by weight or less, based on the raw material. However, in the case of long-term intake for health purposes, the amount may be less than the above range, and since there is no problem in terms of safety, the active ingredient may be used in an amount above the above range.
상기 건강기능식품의 종류에 특별한 제한은 없다. 상기 건강기능식품 조성물을 첨가할 수 있는 식품의 예로는 육류, 소시지, 빵, 초콜릿, 캔디류, 스낵류, 과자류, 피자, 라면, 기타 면류, 껌류, 아이스크림류를 포함한 낙농제품, 각종 스프, 음료수, 차 드링크제, 알콜 음료 및 비타민 복합제 등이 있으며, 통상적인 의미에서의 건강식품을 모두 포함한다.There is no particular limitation on the type of the health functional food. Examples of foods to which the health functional food composition can be added include meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gum, dairy products including ice cream, various soups, beverages, tea There are drinks, alcoholic beverages, vitamin complexes, etc., and includes all health foods in the ordinary sense.
또한, 본 발명의 건강기능식품 조성물은 식품, 특히 기능성 식품으로 제조될 수 있다. 본 발명의 기능성 식품은 통상적으로 첨가되는 성분을 포함할 수 있다. 예를 들어, 단백질, 탄수화물, 지방, 영양소 및 조미제를 포함한다. 예컨대, 드링크제로 제조되는 경우에는 유효성분 이외에 천연 탄수화물 또는 향미제를 추가 성분으로서 포함시킬 수 있다. 상기 천연 탄수화물은 모노사카라이드(예컨대, 글루코오스, 프럭토오스 등), 디사카라이드(예컨대, 말토스, 수크로오스 등), 올리고당, 폴리사카라이드(예컨대, 덱스트린, 시클로덱스트린 등) 또는 당알코올(예컨대, 자일리톨, 소르비톨, 에리쓰리톨 등)인 것이 바람직하다. 상기 향미제는 천연 향미제(예컨대, 타우마틴, 스테비아 추출물 등)와 합성 향미제(예컨대, 사카린, 아스파르탐 등)를 이용할 수 있다.In addition, the health functional food composition of the present invention may be prepared as a food, particularly a functional food. The functional food of the present invention may include ingredients that are usually added. Examples include proteins, carbohydrates, fats, nutrients and seasonings. For example, when manufactured as a drink, natural carbohydrates or flavoring agents may be included as additional ingredients in addition to the active ingredient. The natural carbohydrates include monosaccharides (eg, glucose, fructose, etc.), disaccharides (eg, maltose, sucrose, etc.), oligosaccharides, polysaccharides (eg, dextrin, cyclodextrin, etc.) or sugar alcohols (eg, , xylitol, sorbitol, erythritol, etc.) is preferable. As the flavoring agent, natural flavoring agents (eg, taumartin, stevia extract, etc.) and synthetic flavoring agents (eg, saccharin, aspartame, etc.) may be used.
상기 건강기능식품 조성물 이외에 여러 가지 영양제, 비타민, 전해질, 풍미제, 착색제, 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알콜, 탄산음료에 사용되는 탄산화제 등을 더 함유할 수 있다.In addition to the health functional food composition, various nutrients, vitamins, electrolytes, flavoring agents, coloring agents, pectic acid and its salts, alginic acid and its salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohol, carbonic acid It may further contain a carbonation agent and the like used in beverages.
본 발명은 또한, 석류, 곰취 분말, 나한과 분말 및 물을 혼합한 혼합물에 표고버섯 균사체를 혼합하여 배양한 배양물을 건조한 후 분쇄한 석류 발효 분말을 유효성분으로 함유하는 피부 미백 및 주름 개선용 화장료 조성물을 제공한다.The present invention also provides for skin whitening and wrinkle improvement containing pomegranate fermented powder as an active ingredient after drying a cultured culture by mixing shiitake mushroom mycelium in a mixture of pomegranate, gomchwi powder, ragweed powder and water. A cosmetic composition is provided.
본 발명의 화장료 조성물에 있어서, 상기 피부 미백 및 주름 개선용 화장료 조성물은 피부외용 연고, 크림, 유연화장수, 영양화장수, 팩, 에센스, 헤어토닉, 샴푸, 린스, 헤어 컨디셔너, 헤어 트리트먼트, 젤, 스킨로션, 스킨소프너, 스킨토너, 아스트린젠트, 로션, 밀크로션, 모이스처 로션, 영양로션, 마사지 크림, 영양크림, 모이스처 크림, 핸드 크림, 파운데이션, 영양에센스, 선스크린, 비누, 클렌징폼, 클렌징로션, 클렌징크림, 바디 로션 및 바디 클렌저로 이루어지는 군으로부터 선택된 어느 하나의 제형을 가질 수 있으나, 이에 제한되지 않는다. 이들 각 제형으로 이루어진 화장료 조성물은 그 제형의 제제화에 필요하고 적절한 각종의 기제와 첨가물을 함유할 수 있으며, 이들 성분의 종류와 양은 당업자에 의해 용이하게 선정될 수 있다.In the cosmetic composition of the present invention, the cosmetic composition for skin whitening and wrinkle improvement is an external skin ointment, cream, softening lotion, nutrient lotion, pack, essence, hair tonic, shampoo, conditioner, hair conditioner, hair treatment, gel, Skin Lotion, Skin Softener, Skin Toner, Astringent, Lotion, Milk Lotion, Moisture Lotion, Nourishing Lotion, Massage Cream, Nourishing Cream, Moisture Cream, Hand Cream, Foundation, Nourishing Essence, Sunscreen, Soap, Cleansing Foam, Cleansing Lotion, It may have any one formulation selected from the group consisting of cleansing cream, body lotion, and body cleanser, but is not limited thereto. The cosmetic composition composed of each of these formulations may contain various bases and additives necessary and appropriate for the formulation of the formulation, and the types and amounts of these components can be easily selected by those skilled in the art.
본 발명의 화장료 조성물의 제형이 페이스트, 크림 또는 겔인 경우에는 담체 성분으로서 동물섬유, 식물섬유, 왁스, 파라핀, 전분, 트라가칸트, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크 또는 산화아연 등이 이용될 수 있다.When the formulation of the cosmetic composition of the present invention is a paste, cream or gel, animal fiber, vegetable fiber, wax, paraffin, starch, tragacanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide as a carrier component etc. may be used.
본 발명의 화장료 조성물의 제형이 파우더 또는 스프레이인 경우에는 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄 히드록시드, 칼슘 실리케이트 또는 폴리아미드 파우더가 이용될 수 있고, 특히 스프레이인 경우에는 추가적으로 클로로플루오로히드로카본, 프로판-부탄 또는 디메틸 에테르와 같은 추진체를 포함할 수 있다.When the formulation of the cosmetic composition of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in particular, in the case of a spray, additional chlorofluorohydro It may contain a propellant such as carbon, propane-butane or dimethyl ether.
본 발명의 화장료 조성물의 제형이 용액 또는 유탁액의 경우에는 담체 성분으로서 용매, 용매화제 또는 유탁화제가 이용되고, 예컨대 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌글리콜, 1,3-부틸글리콜 오일, 글리세롤 지방족 에스테르, 폴리에틸렌 글리콜 또는 소르비탄의 지방산 에스테르가 있다.When the formulation of the cosmetic composition of the present invention is a solution or emulsion, a solvent, solvating agent or emulsifying agent is used as a carrier component, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene fatty acid esters of glycol, 1,3-butylglycol oil, glycerol fatty esters, polyethylene glycol or sorbitan.
본 발명의 화장료 조성물의 제형이 현탁액인 경우에는 담체 성분으로서 물, 에탄올 또는 프로필렌 글리콜과 같은 액상 희석제, 에톡실화 이소스테아릴 알코올, 폴리옥시에틸렌 소르비톨 에스테르 및 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소결정성 셀룰로오스, 알루미늄 메타히드록시드, 벤토나이트, 아가 또는 트라칸트 등이 이용될 수 있다.When the formulation of the cosmetic composition of the present invention is a suspension, as a carrier component, a liquid diluent such as water, ethanol or propylene glycol, ethoxylated isostearyl alcohol, a suspending agent such as polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester; Microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tracanth may be used.
본 발명의 화장료 조성물의 제형이 계면-활성제 함유 클렌징인 경우에는 담체 성분으로서 지방족 알코올 설페이트, 지방족 알코올 에테르설페이트, 설포숙신산 모노에스테르, 아세티오네이트, 이미다졸리늄 유도체, 메틸타우레이트, 사르코시네이트, 지방산 아미드 에테르 설페이트, 알킬아미도베타인, 지방족 알코올, 지방산 글리세리드, 지방산 디에탄올아미드, 식물성 유, 리놀린 유도체 또는 에톡실화 글리세롤 지방산 에스테르 등이 이용될 수 있다.When the formulation of the cosmetic composition of the present invention is surfactant-containing cleansing, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, acetionate, imidazolinium derivative, methyl taurate, sarcosinate as carrier components , fatty acid amide ether sulfate, alkylamidobetaine, fatty alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, linolin derivative or ethoxylated glycerol fatty acid ester, and the like can be used.
본 발명의 화장료 조성물은 형광물질, 살진균제, 굴수성 유발물질, 보습제, 방향제, 방향제 담체, 단백질, 용해화제, 당 유도체, 일광차단제, 비타민, 식물 추출물 등을 포함하는 부형제를 추가로 함유할 수 있다.The cosmetic composition of the present invention may further contain excipients including fluorescent substances, fungicides, hydrophobicity inducers, moisturizers, fragrances, fragrance carriers, proteins, solubilizers, sugar derivatives, sunscreens, vitamins, plant extracts, and the like. .
이하, 본 발명의 실시예를 들어 상세히 설명한다. 단, 하기 실시예는 본 발명을 예시하는 것일 뿐, 본 발명의 내용이 하기 실시예에 한정되는 것은 아니다.Hereinafter, an embodiment of the present invention will be described in detail. However, the following examples only illustrate the present invention, and the content of the present invention is not limited to the following examples.
실시예 1. 석류 발효 분말Example 1. Pomegranate Fermented Powder
(1) 혼합물 총 중량 기준으로, 석류 과실 65 중량%, 곰취잎 분말 10 중량%, 나한과 분말(오붐주식회사) 10 중량% 및 정제수 15 중량%를 혼합한 혼합물을 121℃에서 30분 동안 멸균하였다.(1) Based on the total weight of the mixture, a mixture of 65% by weight of pomegranate fruit, 10% by weight of Gomchwilea powder, 10% by weight of Nahanwa powder (Oboom Co., Ltd.) and 15% by weight of purified water was sterilized at 121°C for 30 minutes. .
(2) 상기 (1)단계의 멸균한 혼합물에 배양된 표고버섯 균사체를 혼합하여 25℃에서 14일 동안 배양하였다.(2) The cultured shiitake mushroom mycelium was mixed with the sterilized mixture of step (1) and cultured at 25° C. for 14 days.
(3) 상기 (2)단계의 배양한 배양물을 동결건조한 후 분쇄하였다.(3) The cultured culture in step (2) was freeze-dried and then pulverized.
비교예 1. 석류 분말Comparative Example 1. Pomegranate Powder
석류 과실을 동결건조한 후 분쇄하였다.The pomegranate fruit was freeze-dried and then pulverized.
비교예 2. 석류 발효 분말Comparative Example 2. Pomegranate Fermented Powder
(1) 석류 과실을 121℃에서 30분 동안 멸균하였다.(1) Pomegranate fruits were sterilized at 121°C for 30 minutes.
(2) 상기 (1)단계의 멸균한 석류 과실을 배양된 표고버섯 균사체를 혼합하여 25℃에서 14일 동안 배양하였다.(2) The sterilized pomegranate fruit of step (1) was mixed with the cultured shiitake mushroom mycelium and cultured at 25° C. for 14 days.
(3) 상기 (2)단계의 배양한 배양물을 동결건조한 후 분쇄하였다.(3) The cultured culture in step (2) was freeze-dried and then pulverized.
비교예 3. 석류 분말Comparative Example 3. Pomegranate Powder
(1) 혼합물 총 중량 기준으로, 석류 과실 65 중량%, 곰취잎 분말 10 중량%, 나한과 분말(오붐주식회사) 10 중량% 및 정제수 15 중량%를 혼합한 혼합물을 121℃에서 30분 동안 멸균하였다.(1) Based on the total weight of the mixture, a mixture of 65% by weight of pomegranate fruit, 10% by weight of Gomchwilea powder, 10% by weight of Nahanwa powder (Oboom Co., Ltd.) and 15% by weight of purified water was sterilized at 121°C for 30 minutes. .
(2) 상기 (1)단계의 멸균한 혼합물을 동결건조한 후 분쇄하였다.(2) The sterilized mixture of step (1) was freeze-dried and then pulverized.
비교예 4. 석류 발효 분말Comparative Example 4. Pomegranate Fermented Powder
상기 실시예 1의 방법으로 석류 발효 분말을 제조하되, (1)단계의 혼합 시 혼합물 총 중량 기준으로, 석류 과실 65 중량%, 곰취잎 분말 20 중량% 및 정제수 15 중량%를 혼합한 혼합물을 이용하여, 석류 발효 분말을 제조하였다A pomegranate fermented powder was prepared by the method of Example 1, but when mixing in step (1), a mixture of 65 wt% of pomegranate fruit, 20 wt% of Gomchwiap powder, and 15 wt% of purified water was used based on the total weight of the mixture. Thus, pomegranate fermented powder was prepared
비교예 5. 석류 발효 분말Comparative Example 5. Pomegranate Fermented Powder
상기 실시예 1의 방법으로 석류 발효 분말을 제조하되, (1)단계의 혼합 시 혼합물 총 중량 기준으로, 석류 과실 65 중량%, 나한과 분말(오붐주식회사) 20 중량% 및 정제수 15 중량%를 혼합한 혼합물을 이용하여, 석류 발효 분말을 제조하였다A fermented pomegranate powder was prepared by the method of Example 1, but 65 wt% of pomegranate fruit, 20 wt% of Nahanwa powder (Oboom Co., Ltd.) and 15 wt% of purified water were mixed based on the total weight of the mixture when mixing in step (1). One mixture was used to prepare pomegranate fermented powder
실시예 2. 건강기능식품Example 2. Health functional food
상기 실시예 1의 석류 발효 분말 35 중량%와 콜라겐 분말 45 중량%, 유자 추출 분말 10 중량%, 석류 물 추출 분말 5 중량%, 비타민 C 분말 2 중량% 및 포도당 3 중량%를 혼합하여 분말 형태의 피부 미용을 위한 건강기능식품을 제조하였다.35% by weight of the fermented pomegranate powder of Example 1, 45% by weight of collagen powder, 10% by weight of citron extract powder, 5% by weight of pomegranate extract powder, 2% by weight of vitamin C powder, and 3% by weight of glucose were mixed to form a powder. Health functional food for skin beauty was manufactured.
실시예 3. 크림 화장료Example 3. Cream Cosmetics
상기 실시예 1의 석류 발효 분말과 글리세린, 세테아릴알코올, 폴리소르베이트, 디메치콘, 베타인, 스테아린산, 솔비탄스테아레이트, 광물유, 프리옥타노인, 트리에탄올아민, 방부제, 향료, 색소 및 증류수 등을 적정량 배합하였다. The pomegranate fermented powder of Example 1 and glycerin, cetearyl alcohol, polysorbate, dimethicone, betaine, stearic acid, sorbitan stearate, mineral oil, preoctanoin, triethanolamine, preservatives, fragrances, colorants, distilled water, etc. was blended in an appropriate amount.
실험예 1. 세포 생존율 분석Experimental Example 1. Analysis of cell viability
B16F10 마우스 멜라노마 세포를 배양하여 96-웰 플레이트에 각 웰당 1×105 세포수/㎖를 분주하고 배양하여 24시간 동안 안정화시킨 후, 석류 분말을 각각 100 및 200 ㎍/㎖의 농도로 처리하여 24시간 반응 후 MTT(3-(4,5-디메틸디아졸-2-일)-2,5-데펜테르라졸리움 프로미드) 시약을 10㎕ 첨가하여 4시간 동안 포르마잔(formazan)을 형성시켰다. 반응이 끝나면 배지를 제거하고 디메틸 설폭시드(dimethyl sulfoxide; DMSO)로 포르마잔을 용해시켜 ELISA 리더를 이용하여 540 nm에서 흡광도를 측정하고 그 결과를 아무것도 처리하지 않은 대조군 값에 대한 비율로 계산하였다.B16F10 mouse melanoma cells were cultured, 1×10 5 cells/ml per well was dispensed in a 96-well plate, and the cells were stabilized for 24 hours. Then, pomegranate powder was treated at a concentration of 100 and 200 μg/ml, respectively. After 24 hours of reaction, 10 μl of MTT (3-(4,5-dimethyldiazol-2-yl)-2,5-depenterazolium promid) reagent was added to form formazan for 4 hours. . At the end of the reaction, the medium was removed, formazan was dissolved with dimethyl sulfoxide (DMSO), absorbance was measured at 540 nm using an ELISA reader, and the result was calculated as a ratio to the control value that was not treated with anything.
그 결과, 상기 표 1에 비교한 바와 같이, 모든 처리 농도에서 실시예 1과 비교예들의 석류 분말은 세포 독성이 없는 것을 확인하였다.As a result, as compared to Table 1, it was confirmed that the pomegranate powders of Example 1 and Comparative Examples had no cytotoxicity at all treatment concentrations.
실험예 2. 멜라닌 생성 저해효과 확인Experimental Example 2. Confirmation of melanin production inhibitory effect
멜라닌 생성량 측정은 B16/F10 멜라노 세포를 배양하여 24 웰 플레이트에 각 웰당 세포를 1×105 세포/웰에 시료를 처리한 후 48시간 배양하였다. 48시간 배양한 후 각 웰을 PBS로 세척한 후 0.2N NaOH 용액 400 ㎕를 첨가하고 60℃에서 1시간 동안 용해하였으며, ELISA 리더(Molecular Devices, USA)를 이용하여 405 ㎚에서 흡광도를 측정하였다.For measurement of melanin production, B16/F10 melanocytes were cultured, cells per well in a 24-well plate were treated with a sample at 1×10 5 cells/well, and then cultured for 48 hours. After incubation for 48 hours, each well was washed with PBS, then 400 μl of 0.2N NaOH solution was added and dissolved at 60° C. for 1 hour, and absorbance was measured at 405 nm using an ELISA reader (Molecular Devices, USA).
그 결과, 상기 표 2에 비교한 바와 같이, 100 및 200 ㎎/㎖의 시료 처리 시 실시예 1이 비교예들에 비해 멜라닌 생성 저해효과가 현저하였으며, 비교예 1이 가장 낮은 저해능을 나타내었다.As a result, as compared to Table 2, when 100 and 200 mg / ㎖ of sample treatment Example 1 compared to Comparative Examples the melanin production inhibitory effect was remarkable, Comparative Example 1 showed the lowest inhibitory ability.
실험예 3. 엘라스타아제 저해 활성 확인Experimental Example 3. Elastase inhibitory activity confirmation
본 발명의 시료의 엘라스타아제 저해 활성을 확인하기 위하여, 0.4M의 Tris-HCl 버퍼 (pH 8.6)을 50 ㎕, 농도별 시료를 50 ㎕, 50 mM의 Tris-HCl 버퍼(pH 8.6)에 0.6 U/ml이 되도록 희석한 효소(ex-porcine pancreas) 50 ㎕를 넣고 37℃에서 30분간 반응시킨 후 기질(methoxysuccinyl-LAla-L-Val-5-nitroanilide)을 100 ㎕를 넣은 후 37℃에서 30분간 반응시킨 후 다시 410 nm에서 흡광도를 측정하였다.In order to confirm the elastase inhibitory activity of the sample of the present invention, 50 μl of 0.4M Tris-HCl buffer (pH 8.6), 50 μl of each concentration sample, 0.6 in 50 mM Tris-HCl buffer (pH 8.6) Add 50 μl of dilute enzyme (ex-porcine pancreas) to U/ml, react at 37°C for 30 minutes, and then add 100 μl of substrate (methoxysuccinyl-LAla-L-Val-5-nitroanilide), and After reacting for a minute, the absorbance was again measured at 410 nm.
그 결과, 표 3에 개시한 바와 같이, 모든 시료에서 엘라스타아제 저해 활성이 있는 것으로 나타났다. 특히, 실시예 1의 석류 발효 분말의 엘라스타아제 저해활성이 통계적으로 유의미하게 증가된 것을 확인하였다(p<0.05).As a result, as shown in Table 3, it was found that all samples had elastase inhibitory activity. In particular, it was confirmed that the elastase inhibitory activity of the fermented pomegranate powder of Example 1 was statistically significantly increased ( p <0.05).
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KR20030055950A (en) * | 2001-12-27 | 2003-07-04 | 나드리화장품주식회사 | Cosmetic composition containing punica granatum l. extract for anti-aging effect |
KR100773856B1 (en) * | 2006-06-02 | 2007-11-06 | 주식회사 바이오랜드 | Composition comprising an extract of siraitia grosvenori or triterpene compound isolated therefrom showing anti-wrinkle activity |
KR20190078911A (en) * | 2017-12-27 | 2019-07-05 | 재단법인 홍천메디칼허브연구소 | Food composition for improvement of aging and immunity with the hot water extract of Cirsium setidens Nakai and Ligularia fischeri |
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KR20030055950A (en) * | 2001-12-27 | 2003-07-04 | 나드리화장품주식회사 | Cosmetic composition containing punica granatum l. extract for anti-aging effect |
KR100773856B1 (en) * | 2006-06-02 | 2007-11-06 | 주식회사 바이오랜드 | Composition comprising an extract of siraitia grosvenori or triterpene compound isolated therefrom showing anti-wrinkle activity |
KR20190078911A (en) * | 2017-12-27 | 2019-07-05 | 재단법인 홍천메디칼허브연구소 | Food composition for improvement of aging and immunity with the hot water extract of Cirsium setidens Nakai and Ligularia fischeri |
KR20190090129A (en) * | 2018-01-24 | 2019-08-01 | 신성대학교 산학협력단 | Manufacturing method of expanded graphite |
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