CN108149334A - The method and special chip of complicated form microfibre are prepared based on micro-fluidic chip - Google Patents
The method and special chip of complicated form microfibre are prepared based on micro-fluidic chip Download PDFInfo
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- CN108149334A CN108149334A CN201611102522.8A CN201611102522A CN108149334A CN 108149334 A CN108149334 A CN 108149334A CN 201611102522 A CN201611102522 A CN 201611102522A CN 108149334 A CN108149334 A CN 108149334A
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- microfibre
- chip
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/06—Wet spinning methods
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/22—Formation of filaments, threads, or the like with a crimped or curled structure; with a special structure to simulate wool
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F9/00—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments
- D01F9/04—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments of alginates
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- Engineering & Computer Science (AREA)
- Textile Engineering (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The method that complicated form microfibre is prepared based on micro-fluidic chip：Solidify liquid is passed into motive fluid channel, fiber precursor solution is passed into sample flow channel, and the channel outlet on chip side wall is immersed under the liquid level for the container for filling solidify liquid, fiber precursor solution is exported by sample fluidic channels in the solidify liquid being passed into container with constant flow rate, fiber precursor solution is made to be cured reaction in the moment for touching solidify liquid, generates microfibre.The invention further relates to the special chips that complicated form microfibre is prepared based on micro-fluidic chip.Microfibre preparation method proposed by the invention and its used special chip Turin are lived controllably, can realize prepared by the automation of complex topography microfibre；It is widely used, method is flexible, easy to operate, and equipment cost is low, conducive to commercialization.
Description
Technical field
The present invention relates to new material technologies and the cross-application technical field of microflow control technique, specifically provide a kind of base
The method and special chip of complicated form microfibre are prepared in micro-fluidic chip.
Background technology
In the prior art, micro-fluidic chip (microfluidic chip) is also known as chip lab (lab on a
Chip), refer to that a Routine Test Lab basic operation unit is integrated on the chip of one piece several square centimeters (or even smaller), by
Microchannel forms network, with controlled fluid through whole system, to replace a kind of technology of the various functions of Routine Test Lab.
Fibrous material is widely used in many industries, and what can often be touched in our daily lifes includes
Artificial synthesized chemical fibre and natural fiber needed for clothing weaving, the optical fiber in telecommunications field, in order to improve in manufacturing industry
The glass fibre that the mechanical property of materials is added, the operation stitching fiber used in medical domain etc..
The fibrous material of micro-meter scale is especially suitable for the application of biomedical sector, such as builds strip or tubulose in vitro
Three-dimensional tissue when need to use fibrous material to be controlled as cytoskeleton functional cell transplanting is carried out disease into the human body
Fibrous material is needed during treatment as the carrier of embedding cell and the barrier for resisting immunological rejection, etc..Micro fibre material is due to tool
There is the features such as great specific surface area, flexible mechanical performance, linear structure easy to operation, be also widely used for many life sections
In the research in field, for example, the carrier of the stent of three-dimensional cell cultivation, functional molecular embedding and sustained release, physiological status are real-time
Implantation material of monitoring, etc..
The conventional method for preparing micro fibre material includes wet spinning, dry spinning, melt spinning, Electrospun etc..But this
A little methods limitation when preparing complicated micro fibre material is very big.Form of these methods to micro fibre material is primarily due to,
Structure, the controlling of composition are poor.It is a current hot spot direction to prepare micrograde polymer fiber using microflow control technique.It borrows
Micro-fluidic distinctive the characteristics of can accurately being manipulated to fluid under micro-meter scale is helped, can be conveniently formed with complex shape
The micro fibre material of state structure is one of method most promising in prepared by micro fibre material.
A kind of highly desirable technique effect of acquisition of people is excellent to prepare complicated form microfibre based on micro-fluidic chip
Method and special chip.
Invention content
It is excellent based on the complicated form microfibre of micro-fluidic chip preparation the object of the present invention is to provide a kind of technique effect
Method and special chip.
The present invention provides a kind of methods that complicated form microfibre is prepared based on micro-fluidic chip, it is characterised in that：Its
Complicated form microfibre is prepared using special chip；Following structures are provided on the basis material of the special chip：One straight
Sample fluidic channels and the parallel motive fluid channel for being distributed in sample fluidic channels surrounding；Sample fluidic channels and kinetic current
Body feeder connection is respectively positioned on the upper surface of chip；Outlet is respectively positioned on the same face side wall of chip；In the chip for being provided with outlet
This surface side wall on, centered on sample fluidic channels export, motive fluid channel outlet is uniformly distributed in sample fluidic channels
Export surrounding；In the position close to outlet, all motive fluid channels are bent to sample fluidic channels direction, and and sample flow
Body channel forms a fixed angle, i.e., all motive fluid channels on same special chip and sample fluidic channels institute into
Angle it is identical；Close to outlet port, the fixed angle formed between motive fluid channel and sample fluidic channels is adjustable,
Range is between 0 ° to 90 °；
The requirement of complicated form microfibre is prepared using special chip is：Solidify liquid is passed into motive fluid channel,
Fiber precursor solution is passed into sample flow channel, and the channel outlet on chip side wall is immersed in the appearance for filling solidify liquid
Under the liquid level of device, fiber precursor solution is exported by the solidify liquid being passed into container by sample fluidic channels with constant flow rate
In, fiber precursor solution is made to be cured reaction in the moment for touching solidify liquid, generates microfibre.
The method that complicated form microfibre is prepared based on micro-fluidic chip, it is characterised in that：It is being continuously generated fento
During dimension, the solidify liquid in motive fluid channel is controlled to be passed into container by motive fluid channel outlet, generate spray
Jet stream, and the microfibre in curing is disturbed, lead to microfibre flexural deformation, and by further curing, generation has complexity
The microfibre of form.
The method that complicated form microfibre is prepared based on micro-fluidic chip, it is characterised in that：By using solenoid valve
And program-controlled equipment, the flowing of the solidify liquid in each motive fluid channel is accurately controlled with stopping, so as to fulfill right
The form of microfibre is controlled；To prepare the variform microfibre with controlled dimensions, fibre morphology is following several
One or a combination set of kind：Waveform, spiral shape, ball-joint shape, etc..
In special chip, motive fluid number of channels is adjustable, is evenly arranged in around sample fluidic channels and integral array
Form is one of following concentration macroscopic patterns：Linear, triangle, square, circle.
The special chip for the method that complicated form microfibre is prepared based on micro-fluidic chip is also claimed in the present invention, is
Micro-fluidic chip；It is characterized in that：Following structures are provided on the basis material of the special chip：One straight sample fluid
Channel and the parallel motive fluid channel for being distributed in sample fluidic channels surrounding；Sample fluidic channels and motive fluid feeder connection
It is respectively positioned on the upper surface of chip；Outlet is respectively positioned on the same face side wall of chip；In this surface side wall for the chip for being provided with outlet
On, centered on sample fluidic channels export, motive fluid channel outlet is uniformly distributed in sample fluidic channels outlet surrounding；
Close to the position of outlet, all motive fluid channels are bent to sample fluidic channels direction, and are formed with sample fluidic channels
All motive fluid channels and sample fluidic channels angulation phase on one fixed angle, i.e. same special chip
Together；Close to outlet port, the fixed angle formed between motive fluid channel and sample fluidic channels is adjustable, and range is at 0 °
To between 90 °；
The special chip of the method that complicated form microfibre is prepared based on micro-fluidic chip, it is characterised in that：Also set
It is equipped with one or a combination set of following ancillary equipments：
First, it is used to that the solidify liquid in motive fluid channel be controlled to pass through kinetic current during microfibre is continuously generated
Body channel outlet is passed into container to generate the equipment of injection stream；
Second, the microfibre in disturbance curing is so that the equipment of microfibre flexural deformation, passes through further solid later
Change, you can microfibre of the generation with complicated form.
Third, solenoid valve and/or program-controlled equipment：So as to the flowing of the solidify liquid in each motive fluid channel with stopping
It is only accurately controlled, is controlled so as to fulfill the form to microfibre；To prepare a variety of shapes with controlled dimensions
State microfibre, fibre morphology are one of the following or a combination thereof：Waveform, spiral shape, ball-joint shape, etc..
The special chip of the method that complicated form microfibre is prepared based on micro-fluidic chip, it is characterised in that：It is special
In chip, motive fluid number of channels is adjustable, is evenly arranged in around sample fluidic channels and integral array form is following collection
One of middle macroscopic pattern：Linear, triangle, square, circle.
Microfibre preparation method proposed by the invention and its used special chip Turin are lived controllably, are had following excellent
Point：
1. controlling the form of microfibre by program, realize prepared by the automation of complex topography microfibre；
2. fiber producing processes are flexible, easy to operate, equipment cost is low, conducive to commercialization；
3. the type and pattern of the fibrous material that can be prepared are various, it is widely used.
Description of the drawings
Below in conjunction with the accompanying drawings and embodiment the present invention is described in further detail：
Fig. 1 is micro-fluidic chip schematic diagram of the tool there are four motive fluid channel；
Fig. 2 is the schematic diagram front view of the slave micro-fluidic chip channel design of corresponding diagram 1；
Fig. 3 is the schematic diagram left view of the slave micro-fluidic chip channel design of corresponding diagram 1；
Fig. 4 is the schematic diagram vertical view of the slave micro-fluidic chip channel design of corresponding diagram 1；
Fig. 5 is the schematic diagram that straight microfibre is prepared using micro-fluidic chip；
Fig. 6 is one of schematic diagram of microfibre that bending is prepared using micro-fluidic chip；
Fig. 7 is the two of the schematic diagram for the microfibre that bending is prepared using micro-fluidic chip.
Specific embodiment
Reference numeral meaning in Fig. 1,2 is as follows：
In Fig. 1：I1-I5 is respectively that five i.e. feeder connection A, feeder connection B, feeder connection C-channel entrance D, channel enter
Mouth E, O1-O5 are five channel outlets, that is, channel outlet A, channel outlet B, channel outlet C, channel outlet D, channel outlet E, II
For being passed through fiber precursor solution, I2-I5 is for being passed through solidify liquid, and O1 is spinning nozzle, and 02-05 is injection outflux；
In Fig. 2-4：From vertical view, side view, the schematic diagram of three direction observation micro-fluidic chip channel designs of forward sight, O1-O5
It is spinning nozzle for five channel outlets, that is, channel outlet A, channel outlet B, channel outlet C, channel outlet D, channel outlet E, O1,
02-05 is injection outflux；
In Fig. 5-7：Microfibre in curing bends deformation under the action of injection stream, and after hardening by Curved
State is fixed.
Embodiment 1
A kind of method that complicated form microfibre is prepared based on micro-fluidic chip prepares complicated form using special chip
Microfibre；Following structures are provided on the basis material of the special chip：One straight sample fluidic channels and parallel distribution
In the motive fluid channel of sample fluidic channels surrounding；Sample fluidic channels and motive fluid feeder connection are respectively positioned on the upper of chip
Surface；Outlet is respectively positioned on the same face side wall of chip；On this surface side wall for the chip for being provided with outlet, led to sample fluid
Centered on road outlet, motive fluid channel outlet is uniformly distributed in sample fluidic channels outlet surrounding；Close to outlet position,
All motive fluid channels are bent to sample fluidic channels direction, and form a fixed angle with sample fluidic channels, i.e.,
All motive fluid channels on same special chip are identical with sample fluidic channels angulation；In close outlet position
It puts, the fixed angle formed between motive fluid channel and sample fluidic channels is adjustable, and range is between 0 ° to 90 °；
The requirement of complicated form microfibre is prepared using special chip is：Solidify liquid is passed into motive fluid channel,
Fiber precursor solution is passed into sample flow channel, and the channel outlet on chip side wall is immersed in the appearance for filling solidify liquid
Under the liquid level of device, fiber precursor solution is exported by the solidify liquid being passed into container by sample fluidic channels with constant flow rate
In, fiber precursor solution is made to be cured reaction in the moment for touching solidify liquid, generates microfibre.
During microfibre is continuously generated, the solidify liquid in motive fluid channel is controlled to go out by motive fluid channel
Mouth is passed into container, generates injection stream, and disturbs the microfibre in curing, leads to microfibre flexural deformation, and pass through into one
The curing of step, microfibre of the generation with complicated form.
It, can be to the flowing of the solidify liquid in each motive fluid channel with stopping by using solenoid valve and program-controlled equipment
It is only accurately controlled, is controlled so as to fulfill the form to microfibre；To prepare a variety of shapes with controlled dimensions
State microfibre, fibre morphology are one of the following or a combination thereof：Waveform, spiral shape, ball-joint shape, etc..
In special chip, motive fluid number of channels is adjustable, is evenly arranged in around sample fluidic channels and integral array
Form is one of following concentration macroscopic patterns：Linear, triangle, square, circle.
The special chip of the method for complicated form microfibre is prepared based on micro-fluidic chip, is micro-fluidic chip；It is described
Following structures are provided on the basis material of special chip：One straight sample fluidic channels is led to the parallel sample fluid that is distributed in
The motive fluid channel of road surrounding；Sample fluidic channels and motive fluid feeder connection are respectively positioned on the upper surface of chip；Outlet is equal
On the same face side wall of chip；On this surface side wall for the chip for being provided with outlet, using sample fluidic channels outlet in
The heart, motive fluid channel outlet are uniformly distributed in sample fluidic channels outlet surrounding；In the position close to outlet, all kinetic currents
Body channel is bent to sample fluidic channels direction, and forms a fixed angle with sample fluidic channels, i.e. same is special
All motive fluid channels on chip are identical with sample fluidic channels angulation；Close to outlet port, motive fluid
The fixed angle formed between channel and sample fluidic channels is adjustable, and range is between 0 ° to 90 °；
In the special chip of the method that complicated form microfibre is prepared based on micro-fluidic chip, it is additionally provided with following auxiliary
Help one or a combination set of equipment：
First, it is used to that the solidify liquid in motive fluid channel be controlled to pass through kinetic current during microfibre is continuously generated
Body channel outlet is passed into container to generate the equipment of injection stream；
Second, the microfibre in disturbance curing is so that the equipment of microfibre flexural deformation, passes through further solid later
Change, you can microfibre of the generation with complicated form.
Third, solenoid valve and/or program-controlled equipment：So as to the flowing of the solidify liquid in each motive fluid channel with stopping
It is only accurately controlled, is controlled so as to fulfill the form to microfibre；To prepare a variety of shapes with controlled dimensions
State microfibre, fibre morphology are one of the following or a combination thereof：Waveform, spiral shape, ball-joint shape, etc..
The special chip of the method that complicated form microfibre is prepared based on micro-fluidic chip, it is characterised in that：It is special
In chip, motive fluid number of channels is adjustable, is evenly arranged in around sample fluidic channels and integral array form is following collection
One of middle macroscopic pattern：Linear, triangle, square, circle.
The microfibre preparation method and its used special chip Turin that the present embodiment is proposed are lived controllably, are had following
Advantage：
1. controlling the form of microfibre by program, realize prepared by the automation of complex topography microfibre；
2. fiber producing processes are flexible, easy to operate, equipment cost is low, conducive to commercialization；
3. the type and pattern of the fibrous material that can be prepared are various, it is widely used.
Embodiment 2
The preparation of waveform calcium alginate microfibre：Waveform sea is prepared using micro-fluidic chip as shown in Figure 1
Sorbsan, the diameter of O1-O5 channel outlets is 100x100um.Prepare sodium alginate aqueous solution (NaA, 2wt%) and chlorine
Change calcium aqueous solution (CaCl2, 2wt%).NaA solution is passed into I1 entrances, by CaCl2Solution is divided into four parts, each leads into
I2-I5 entrances.Chip outlet is immersed into CaCl2In aqueous solution, NaA solution is continually fed into the flow velocity of 2uL/min, makes it logical
It crosses O1 spinning nozzles and forms calcium alginate (CaA) microfibre.Continued with the flow velocity of 5uL/min by CaCl2Solution is led to by O2 and O3
Road outlet is passed into CaCl2In solution pool, pass through the CaCl of O4 and O5 channel outlets using program-controlled solenoid valve control2Solution
Flowing, makes solution in two channels be ejected into CaCl with the mode spacing of " this opens that pass "2In solution pool (5uL/min flow velocitys),
It is 500ms every the time, microfibre is made to generate primary reversed bending every 500ms, ultimately forms waveform CaA fibers.
Embodiment 3
The preparation of scroll calcium alginate microfibre：
Using as shown in Figure 1 micro-fluidic chip prepare waveform calcium alginate fibre, O1-O5 channel outlets it is straight
Diameter is 100x100um.Prepare sodium alginate aqueous solution (NaA, 2wt%) and calcium chloride water (CaCl2, 2wt%).It will
NaA solution is passed into I1 entrances, by CaCl2Solution is divided into four parts, each leads into I2-I5 entrances.Chip outlet is immersed into
CaCl2In aqueous solution, NaA solution is continually fed into the flow velocity of 2uL/min, O1 spinning nozzles is made it through and forms calcium alginate
(CaA) microfibre.Pass through the CaCl of O1-O5 channel outlets using program-controlled solenoid valve control2The flowing of solution makes four channels
Interior solution successively cyclic spray to CaCl2(5uL/min flow velocitys), interval time 500ms in solution pool, make microfibre every
500ms generates primary bending, ultimately forms scroll CaA fibers.
Claims (7)
1. the method for complicated form microfibre is prepared based on micro-fluidic chip, it is characterised in that：It is prepared multiple using special chip
Miscellaneous form microfibre；Following structures are provided on the basis material of the special chip：One straight sample fluidic channels peace
Row is distributed in the motive fluid channel of sample fluidic channels surrounding；Sample fluidic channels and motive fluid feeder connection are respectively positioned on core
The upper surface of piece；Outlet is respectively positioned on the same face side wall of chip；On this surface side wall for the chip for being provided with outlet, with sample
Centered on outlet flow channels, motive fluid channel outlet is uniformly distributed in sample fluidic channels outlet surrounding；In close outlet
Position, all motive fluid channels to sample fluidic channels direction be bent, and with sample fluidic channels formed a fixation
All motive fluid channels in angle, i.e. same special chip are identical with sample fluidic channels angulation；Fixed angles
Degree is between 0 ° to 90 °；
The requirement of complicated form microfibre is prepared using special chip is：Solidify liquid is passed into motive fluid channel, it will be fine
Dimension precursor solution is passed into sample flow channel, and the channel outlet on chip side wall is immersed in the container for filling solidify liquid
Under liquid level, fiber precursor solution is exported by sample fluidic channels in the solidify liquid being passed into container with constant flow rate, is made
Fiber precursor solution is cured reaction in the moment for touching solidify liquid, generates microfibre.
2. according to the method for preparing complicated form microfibre described in claim 1 based on micro-fluidic chip, it is characterised in that：It is holding
During continuous generation microfibre, the solidify liquid in motive fluid channel is controlled to be passed into container by motive fluid channel outlet
It is interior, injection stream is generated, and disturb the microfibre in curing, lead to microfibre flexural deformation, and by further curing, generation
Microfibre with complicated form.
3. according to the method for preparing complicated form microfibre described in claims 1 or 2 based on micro-fluidic chip, it is characterised in that：
By using solenoid valve and program-controlled equipment, the flowing of the solidify liquid in each motive fluid channel is accurately controlled with stopping
System, controls so as to fulfill the form to microfibre；To prepare the variform microfibre with controlled dimensions, fiber
Form is one of the following or a combination thereof：Waveform, spiral shape, ball-joint shape.
4. according to the method for preparing complicated form microfibre described in claim 3 based on micro-fluidic chip, it is characterised in that：It is special
In chip, motive fluid channel is evenly arranged in around sample fluidic channels and integral array form is following concentration macroscopic patterns
One of：Linear, triangle, square, circle.
It is micro-fluidic chip 5. preparing the special chip of the method for complicated form microfibre based on micro-fluidic chip；Its feature
It is：Following structures are provided on the basis material of the special chip：One straight sample fluidic channels is distributed in parallel
The motive fluid channel of sample fluidic channels surrounding；Sample fluidic channels and motive fluid feeder connection are respectively positioned on the upper table of chip
Face；Outlet is respectively positioned on the same face side wall of chip；On this surface side wall for the chip for being provided with outlet, with sample fluidic channels
Centered on outlet, motive fluid channel outlet is uniformly distributed in sample fluidic channels outlet surrounding；In the position close to outlet, institute
Dynamic fluid channel is bent to sample fluidic channels direction, and forms a fixed angle with sample fluidic channels, i.e., together
All motive fluid channels on one piece of special chip are identical with sample fluidic channels angulation；Fixed angle is arrived at 0 °
Between 90 °.
It is 6. special according to the special chip for the method for preparing complicated form microfibre described in claim 5 based on micro-fluidic chip
Sign is：It is additionally provided with one or a combination set of following ancillary equipments：
First, it is used to that the solidify liquid in motive fluid channel be controlled by motive fluid to lead to during microfibre is continuously generated
Road outlet is passed into container to generate the equipment of injection stream；
Second, the microfibre in disturbance curing is so that the equipment of microfibre flexural deformation；
Third, solenoid valve and/or program-controlled equipment：So as to the flowing to the solidify liquid in each motive fluid channel and stop into
The accurate control of row, controls so as to fulfill the form to microfibre.
It is 7. special according to the special chip for the method for preparing complicated form microfibre described in claim 6 based on micro-fluidic chip
Sign is：In special chip, motive fluid channel is evenly arranged in around sample fluidic channels and integral array form is following
Concentrate one of macroscopic pattern：Linear, triangle, square, circle.
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| CN201611102522.8A CN108149334B (en) | 2016-12-05 | 2016-12-05 | Method for preparing microfiber with complex shape based on microfluidic chip and special chip |
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| CN108149334B CN108149334B (en) | 2021-03-09 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110656387A (en) * | 2019-10-15 | 2020-01-07 | 中国科学院长春应用化学研究所 | Microfluidic biological spinning technology suitable for chemical crosslinking forming |
| CN112853510A (en) * | 2019-11-28 | 2021-05-28 | 中国科学院大连化学物理研究所 | Controllable preparation method of inner groove microfilament based on microfluidic technology |
| CN113913956A (en) * | 2021-09-27 | 2022-01-11 | 南京工业大学 | Micro-fluidic spinning construction method for high-strength spiral fibers |
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