CN108014155A - A kind of preparation method of the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng - Google Patents
A kind of preparation method of the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng Download PDFInfo
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- CN108014155A CN108014155A CN201810092546.2A CN201810092546A CN108014155A CN 108014155 A CN108014155 A CN 108014155A CN 201810092546 A CN201810092546 A CN 201810092546A CN 108014155 A CN108014155 A CN 108014155A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/10—Preparation or pretreatment of starting material
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Abstract
A kind of preparation method of the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng provided by the invention, including will be toasted in American Ginseng section baking oven；Design temperature is 50~70 DEG C in baking oven；Treat that oven temperature drops to less than 40 DEG C, American Ginseng is cut into slices and is taken out；It is then in small, broken bits by the section coarse crushing of dried American Ginseng, obtain American Ginseng fine powder；American Ginseng fine powder is put into mixer, is uniformly mixed；American Ginseng fine powder after mixing is subjected to cobalt radiation sterilization；It is put into micronizer crush and then add ball mill progress ball milling, obtains the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng.A kind of directly oral broken wall prepared slices of Chinese crude drugs character of American Ginseng provided by the invention is powdered, micropowders are added into ball mill and carry out ball milling, by American Ginseng cell wall damage during ball milling, medicinal material active ingredient can be fully discharged after broken wall, so American Ginseng drug ingedient dissolved in human body, infiltration rate it is fast, increase American Ginseng effective ingredient utilization rate.
Description
Technical field
This application involves Chinese medicine manufacture field, more particularly to a kind of preparation side of the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng
Method.
Background technology
The one kind of American Ginseng as ginseng, there is the effect refreshed oneself after taking, can be as the food of daily health caring；Informal dress west
American ginseng can with anti-arrhythmia, resist myocardial ischemia, it is anti-cardiac muscle oxidation, strengthen cardiac contractility ability, patients with coronary heart disease Symptoms
For deficiency of both qi and yin, palpitation and short breath can long-term use of American Ginseng, it is evident in efficacy.
It is mostly currently on the market Western ginseng tablet using American Ginseng as character during health food, it is equal that American Ginseng is made into thin and thick
Even section, takes suitable Western ginseng tablet, adds water to be taken after brewing or decocting a few minutes.
Traditional Chinese medicine composition includes autonomic drug and mineral drug, and wherein autonomic drug account for the overwhelming majority, the drug effect of autonomic drug
Component is mainly distributed in plant cell wall, and when people brew or decoct and take in Yi Shui, part active ingredient is with the dregs of a decoction
Abandon and it is not utilized, cause the reduction of American Ginseng utilization ratio of drug, so as to cause the waste of American Ginseng.
The content of the invention
This application provides a kind of preparation method of the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng, to solve Western ginseng tablet
The problem of utilization ratio of drug is low.
In order to solve the above-mentioned technical problem, the embodiment of the present application discloses following technical solution：
A kind of preparation method of the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng provided by the invention, including：
American Ginseng section is laid in baking pan, the baking pan is put into baking oven and is toasted；Design temperature in the baking oven
For 50~70 DEG C；Treat that the oven temperature drops to less than 40 DEG C, American Ginseng section taking-up is obtained dried American Ginseng cuts
Piece, it is spare；By the dried American Ginseng section coarse crushing, American Ginseng coarse powder is obtained；The American Ginseng coarse powder is in small, broken bits, obtain
American Ginseng fine powder；The American Ginseng fine powder is put into mixer, it is spare after mixing；American Ginseng after mixing is thin
Powder carries out cobalt radiation sterilization；It is put into micronizer to be crushed to obtain micropowders, micropowders is added into ball mill, ball milling
Machine rotating speed is 30~40 revs/min, and Ball-milling Time is 3~7h, obtains the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng.
Preferably, American Ginseng section drying time in baking oven is 6~8h.
Preferably, the dried American Ginseng section moisture is less than 7%.
Preferably, by 20~40 mesh of coarse crushing mesh number during the dried American Ginseng section coarse crushing；The American Ginseng is thick
100~150 mesh of mesh number in small, broken bits when powder is in small, broken bits.
Preferably, the American Ginseng fine particle particle diameter is less than 75 μm.
Preferably, the American Ginseng fine powder in incorporation time in mixer be 28~32min.
Preferably, it is blue cloudy to include aerobic bacteria, yeast and mold, escherichia coli, bile tolerance leather for the cobalt irradiation sterilization
Property bacterium, detection of Salmonella；Wherein aerobic bacteria sum is less than 0.5 × 104Cfu/g, yeast and mold sum are less than 0.5 × 102Cfu/g,
Escherichia coli detected level is less than 1g, and bile tolerance gram-negative bacteria is less than 10cfu/g, and detection of Salmonella detected level is less than 10g.
A kind of preparation method of the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng provided by the invention, including American Ginseng is cut into slices
It is laid in baking pan, the baking pan is put into baking oven and is toasted；Design temperature is 50~70 DEG C in the baking oven；Treat the baking oven
Interior temperature drops to less than 40 DEG C, and American Ginseng section taking-up is obtained dried American Ginseng cuts into slices, spare；Will be described dried
American Ginseng section coarse crushing, obtains American Ginseng coarse powder；The American Ginseng coarse powder is in small, broken bits, obtain American Ginseng fine powder；By described the West
Ginseng fine powder is put into mixer, spare after mixing；American Ginseng fine powder after mixing is subjected to cobalt radiation sterilization；It is put into
Micronizer is crushed to obtain micropowders, and micropowders are added ball mill, and drum's speed of rotation is 30~40 revs/min,
Ball-milling Time is 3~7h, obtains the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng.
A kind of directly oral broken wall prepared slices of Chinese crude drugs character of American Ginseng provided by the invention is powdered, and micropowders are added
Ball mill carries out ball milling, and when ball milling crushes American Ginseng cell membrane, but does not change molecular structure and arrangement, can be after broken wall
Medicinal material active ingredient fully discharges, and after breaking-wall cell, intracellular moisture oil dissolution, makes particulate surface show half
Moisture state, so its dissolved in human body, infiltration rate it is fast, improve American Ginseng drug ingedient uptake, increase American Ginseng
The utilization rate of effective ingredient.
It should be appreciated that the general description and following detailed description of the above are only exemplary and explanatory, not
The application can be limited.
Brief description of the drawings
Attached drawing herein is merged in specification and forms the part of this specification, shows the implementation for meeting the present invention
Example, and for explaining the principle of the present invention together with specification.
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
There is attached drawing needed in technology description to be briefly described, it should be apparent that, for those of ordinary skill in the art
Speech, without having to pay creative labor, can also obtain other attached drawings according to these attached drawings.
Fig. 1 is that a kind of preparation method flow of the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng provided in an embodiment of the present invention is shown
It is intended to.
Embodiment
It is in order to make those skilled in the art better understand the technical solutions in the application, real below in conjunction with the application
The attached drawing in example is applied, the technical solution in the embodiment of the present application is clearly and completely described, it is clear that described implementation
Example only some embodiments of the present application, rather than whole embodiments.Based on the embodiment in the application, the common skill in this area
Art personnel all other embodiments obtained without making creative work, should all belong to the application protection
Scope.
In order that those skilled in the art will better understand the technical solution of the present invention, below in conjunction with the accompanying drawings to the present invention
Technical solution be described in further detail.
Embodiment 1
A kind of preparation method of the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng provided in an embodiment of the present invention, including,
S101：American Ginseng section is laid in baking pan, the baking pan is put into baking oven and is toasted；Setting in the baking oven
Temperature is 50 DEG C；Drying time is set to 6h in baking oven；
S102：Treat that the oven temperature drops to less than 40 DEG C, American Ginseng section taking-up is obtained into dried American Ginseng
Section, it is spare；
S103：By the dried American Ginseng section coarse crushing, 20 mesh of coarse crushing mesh number, obtains American Ginseng coarse powder during coarse crushing；
S104：The American Ginseng coarse powder is in small, broken bits, and 100 mesh of mesh number in small, broken bits, obtains American Ginseng fine powder；The American Ginseng is thin
Powder is put into mixer, mixes 28min, is uniformly mixed；
S105：American Ginseng fine powder after mixing is subjected to cobalt radiation sterilization；
S106：It is put into micronizer to be crushed to obtain micropowders, micropowders is added into ball mill, ball mill turns
Speed is 30 revs/min, Ball-milling Time 3h, obtains the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng.
In the present embodiment, the dried American Ginseng section moisture is less than 7%；The American Ginseng fine particle
Particle diameter is less than 75 μm；
Cobalt irradiation sterilization is the radiation sterilization of cobalt -60, and cobalt -60 is radioactive element, and cobalt -60 is radioactive element, it is declining
Gamma-rays can be produced during change, gamma-rays has higher energy, can make in the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng
The atom and molecule in portion produce excitation and ionization, so that a series of direct or indirect physics, chemistry and biological respinses are produced, this
A little reactions make the inside of the directly oral broken wall prepared slices of Chinese crude drugs molecule of American Ginseng that complicated decomposition and polymerization occur, and destroy and change
The internal structure of biomolecule, so as to play suppression or kill the effect of microorganism；Sterilizing mainly include aerobic bacteria, mould and
Saccharomycete, escherichia coli, bile tolerance gram-negative bacteria, detection of Salmonella, wherein,
Aerobic bacteria sum is less than 0.5 × 10 after cobalt irradiation sterilization4Cfu/g, yeast and mold sum be less than 0.5 ×
102Cfu/g, escherichia coli detected level are less than 1g, and bile tolerance gram-negative bacteria is less than 10cfu/g, and detection of Salmonella detected level is less than
10g。
Embodiment 2
A kind of preparation method of the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng provided in an embodiment of the present invention, including,
S201：American Ginseng section is laid in baking pan, the baking pan is put into baking oven and is toasted；Setting in the baking oven
Temperature is 60 DEG C；Drying time is set to 7h in baking oven；
S202：Treat that the oven temperature drops to less than 40 DEG C, American Ginseng section taking-up is obtained into dried American Ginseng
Section, it is spare；
S203：By the dried American Ginseng section coarse crushing, 30 mesh of coarse crushing mesh number, obtains American Ginseng coarse powder during coarse crushing；
S204：The American Ginseng coarse powder is in small, broken bits, and 125 mesh of mesh number in small, broken bits, obtains American Ginseng fine powder；The American Ginseng is thin
Powder is put into mixer, mixes 30min, is uniformly mixed；
S205：American Ginseng fine powder after mixing is subjected to cobalt radiation sterilization；
S206：It is put into micronizer to be crushed to obtain micropowders, micropowders is added into ball mill, ball mill turns
Speed is 40 revs/min, Ball-milling Time 7h, obtains the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng.
Embodiment 3
A kind of preparation method of the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng provided in an embodiment of the present invention, including,
S301：American Ginseng section is laid in baking pan, the baking pan is put into baking oven and is toasted；Setting in the baking oven
Temperature is 70 DEG C；Drying time is set to 8h in baking oven；
S302：Treat that the oven temperature drops to less than 40 DEG C, American Ginseng section taking-up is obtained into dried American Ginseng
Section, it is spare；
S303：By the dried American Ginseng section coarse crushing, 40 mesh of coarse crushing mesh number, obtains American Ginseng coarse powder during coarse crushing；
S304：The American Ginseng coarse powder is in small, broken bits, and 150 mesh of mesh number in small, broken bits, obtains American Ginseng fine powder；The American Ginseng is thin
Powder is put into mixer, mixes 32min, is uniformly mixed；
S305：American Ginseng fine powder after mixing is subjected to cobalt radiation sterilization；
S306：It is put into micronizer to be crushed to obtain micropowders, micropowders is added into ball mill, ball mill turns
Speed is 35 revs/min, Ball-milling Time 5h, obtains the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng.
To probe into a kind of security of the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng provided by the invention, the embodiment of the present invention
The safety evaluation method of the directly oral broken wall prepared slices of Chinese crude drugs of specific American Ginseng is provided, specific method is as follows：
Alimentary canal is the necessary path of oral administration of drugs, thus study alimentary system change and influence be research to
One of key point influenced after medicine on body.Influence of the medicine to alimentary system is mainly reflected in alimentary canal micro-ecological environment
Influence；Enteric bacteria about 400-500 kinds in people's enteron aisle, are divided into ancestral home flora and foreign nationality's flora, ancestral home flora be mostly enteron aisle just
Normal flora；By very long biological evolution process, normal flora is in commensalism with human body, when normal flora and human body are in
Human body is healthy during the dynamic equilibrium of interdependence, then causes a disease when in imbalance state, therefore intestinal flora is most significant
One of feature is its stability.When human body long-time service antibiotics, the conditioned pathogen such as enterococcus and enterobacteria will
A large amount of increments, and the probiotics such as Bacillus acidi lactici, Bifidobacterium, bacteroid quantity then substantially reduces, and causes the mistake of intestinal flora
Adjust, intestinal bacilli illness the result is that the nutrient absorption of body, immunocompetence etc. are reduced, so as to cause a series of diseases of body
Occur.
This research is by comparing the direct oral medicinal slice of American Ginseng and the influence after traditional medicine materical crude slice administration to intestinal flora, to test
Demonstrate,prove the safety evaluatio of the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng.
Experimental drug is divided into 2 classes and is contrasted by safety evaluation method provided in an embodiment of the present invention, is respectively：Broken wall
Medicine materical crude slice (the directly oral broken wall prepared slices of Chinese crude drugs of the American Ginseng that the application provides), traditional medicine materical crude slice；
The medicine ordinance of traditional medicine materical crude slice：According to important decocting method is faced, take traditional medicine materical crude slice to be put into marmite, shakeout, add water
More than medical surfaces, after soaking 30min, decoct 2 times, half an hour after of seething with excitement every time pours out liquid, merges 2 liquids, is made
1g.22.2mL-1Liquid.
The medicine ordinance of broken wall medicine materical crude slice：It is uniform using preceding first grinding, boiling water is added afterwards, and 1g.22.2mL is made-1Liquid.
Then mouse effect experimental subjects is selected, specific method is：30 mouse are selected, 8 week old, about 18-22g are random to divide
For blank group (not feeding any medicine), broken wall group (the directly oral broken wall prepared slices of Chinese crude drugs of the American Ginseng that feeding the application provides),
Traditional medicine materical crude slice group (feeding American Ginseng tradition medicine materical crude slice), 0.4mL.20g is pressed in every group of half male and half female, daily administration-1, mouse is observed daily
Active situation.
The configuration of culture medium：The culture medium for weighing respective amount is placed in clean conical flask, first adds a small amount of distilled water,
It is placed in heating in the electrothermal furnace for a little having asbestos gauge and makes fully to dissolve with glass bar stirring, its acid-base value is detected with pH test paper, and
Required acid-base value is adjusted to 0.05mol/L NaOH.The culture medium adjusted is sub-packed in sterile conical flask, then used
Clean plug seals and encases bottleneck with brown paper, in autoclave sterilization pot 121 DEG C sterilizing 30min, after take out
It is placed in super-clean bench and is cooled to 40 DEG C, be aseptically sub-packed in 9 ㎝ culture dishes, it is standby to be inverted tablet after culture medium solidification
With.
After liaison is administered 14 days, mouse ileocecus content is taken, dilutes and is inoculated in after homogenizing in corresponding culture medium,
Selectivity culture and counting Bifidobacterium, Bacillus acidi lactici, escherichia coli and enterococcus, compare the change of bacterium before and after administration,
Specific implementation process is as follows：
Stool in mice 0.1g is taken, with physiological saline after 10 times of doubling dilutions, selects suitable dilution factor to be respectively coated on
EA culture mediums (end lattice agar medium), EMB culture mediums (i.e. EMB agar medium), BBL culture mediums (i.e. bifid bar
Bacterio-agar culture medium), on MRS culture mediums (i.e. lactic acid bacteria agar medium), EA culture mediums, EMB cultures are had based on 37 DEG C
Oxygen culture 24h, is respectively used to detection enterococcus and escherichia coli；BBL culture mediums, MRS cultures are based on 37 DEG C of Anaerobic culturels
48h, is respectively used to detection Bifidobacterium and lactic acid bacteria.Average colony number is chosen during counting to be advisable in 35-350 clump count, unites
Count the clump count grown on tablet.
The each group mouse intestinal flora clump count of statistics, it is as follows：
1 each group mouse intestinal flora clump count of table compares
From experimental result, American Ginseng broken wall group, traditional medicine materical crude slice group to mouse intestinal escherichia coli and enterococcus without
Significantly affect, it is seen that American Ginseng is to the conditioned pathogen in intestinal microecology without ill-effect, and broken wall group can also reduce condition
The clump count of pathogenic bacteria；Quantity increase of the broken wall group to mouse intestinal Bacillus acidi lactici and Bifidobacterium, illustrates the direct mouth of American Ginseng
Taking the broken wall prepared slices of Chinese crude drugs has intestinal microecology certain corrective action, and traditional medicine materical crude slice does not have this effect then.
Since embodiment of above is to quote to combine on other modes to illustrate, have between different embodiments
Have an identical part, in this specification part identical, similar between each embodiment mutually referring to.It is no longer detailed herein
Illustrate.
Those skilled in the art will readily occur to the application its after considering specification and putting into practice the disclosure invented here
His embodiment.This application is intended to cover the present invention any variations, uses, or adaptations, these modifications, purposes or
Person's adaptive change follows the general principle of the application and including the undocumented common knowledge in the art of the application
Or conventional techniques.Description and embodiments are considered only as exemplary, and the true scope and spirit of the application will by right
The content asked is pointed out.
Above-described the application embodiment does not form the restriction to the application protection domain.
Claims (7)
- A kind of 1. preparation method of the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng, it is characterised in that including:American Ginseng section is laid in baking pan, the baking pan is put into baking oven and is toasted；Design temperature is 50~70 DEG C in the baking oven；Treat that the oven temperature drops to less than 40 DEG C, American Ginseng section taking-up is obtained dried American Ginseng cuts into slices, spare；By the dried American Ginseng section coarse crushing, American Ginseng coarse powder is obtained；The American Ginseng coarse powder is in small, broken bits, obtain American Ginseng fine powder；The American Ginseng fine powder is put into mixer, mixing is equal It is even；American Ginseng fine powder after mixing is subjected to cobalt radiation sterilization, micronizer is then placed in and is crushed to obtain ultra micro Fine powder；Micropowders are added into ball mill, drum's speed of rotation is 30~40 revs/min, and Ball-milling Time is 3~7h, and it is straight to obtain American Ginseng Interface takes the broken wall prepared slices of Chinese crude drugs.
- 2. the preparation method of the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng according to claim 1, it is characterised in that the West Ginseng section drying time in baking oven is 6~8h.
- 3. the preparation method of the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng according to claim 2, it is characterised in that described Dried American Ginseng section moisture is less than 7%.
- 4. the preparation method of the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng according to claim 1, it is characterised in that by institute 20~40 mesh of coarse crushing mesh number when stating dried American Ginseng section coarse crushing；By the American Ginseng coarse powder it is in small, broken bits when mesh number 100 in small, broken bits ~150 mesh.
- 5. the preparation method of the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng according to claim 4, it is characterised in that described American Ginseng fine particle particle diameter is less than 75 μm.
- 6. the preparation method of the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng according to claim 1, it is characterised in that described American Ginseng fine powder is 28~32min in incorporation time in mixer.
- 7. the preparation method of the directly oral broken wall prepared slices of Chinese crude drugs of American Ginseng according to claim 1, it is characterised in that described Cobalt irradiation sterilization includes aerobic bacteria, yeast and mold, escherichia coli, bile tolerance gram-negative bacteria, detection of Salmonella；WhereinAerobic bacteria sum is less than 0.5 × 104Cfu/g, yeast and mold sum are less than 0.5 × 102Cfu/g, escherichia coli inspection Output is less than 1g, and bile tolerance gram-negative bacteria is less than 10cfu/g, and detection of Salmonella detected level is less than 10g.
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| CN111821329A (en) * | 2019-04-18 | 2020-10-27 | 珠海岐微生物科技有限公司 | Application of ginseng in regulating intestinal microorganisms |
| CN112075623A (en) * | 2020-09-07 | 2020-12-15 | 天马（安徽）国药科技股份有限公司 | Fresh American ginseng powder and production process thereof |
| CN116059107A (en) * | 2021-11-01 | 2023-05-05 | 广东美的生活电器制造有限公司 | Medicinal material processing method, device, apparatus and storage medium |
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| CN104585399A (en) * | 2015-01-21 | 2015-05-06 | 河南科技大学 | Method for preparing American ginseng solid instant tea |
| CN105902587A (en) * | 2016-04-29 | 2016-08-31 | 河北林益堂药业有限公司 | Preparation method of panax quinquefolius raw powder tablets |
| CN106109520A (en) * | 2016-08-08 | 2016-11-16 | 湖南盟合投资管理有限公司 | The preparation method of Radix Panacis Quinquefolii breaking cellular wall decoction pieces |
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| CN108524567A (en) * | 2018-05-17 | 2018-09-14 | 广州艾普纳米科技有限公司 | A kind of preparation method of Chinese medicine wall cell disruption medicine materical crude slice |
| CN111821329A (en) * | 2019-04-18 | 2020-10-27 | 珠海岐微生物科技有限公司 | Application of ginseng in regulating intestinal microorganisms |
| CN112075623A (en) * | 2020-09-07 | 2020-12-15 | 天马（安徽）国药科技股份有限公司 | Fresh American ginseng powder and production process thereof |
| CN116059107A (en) * | 2021-11-01 | 2023-05-05 | 广东美的生活电器制造有限公司 | Medicinal material processing method, device, apparatus and storage medium |
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