CN107929170A - A kind of eucalyptus oil shampoo and its preparation method and application of pet - Google Patents
A kind of eucalyptus oil shampoo and its preparation method and application of pet Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/002—Preparations for repairing the hair, e.g. hair cure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention discloses a kind of eucalyptus oil shampoo and its preparation method and application of pet, which is made of eucalyptus oil, Eclipta prostrata extracting solution, fish pelargonium extracting solution, beer yeast powder, sodium laureth sulfate, lauryl sodium sulfate, empgen BB, lauric acid amide of ethanol, disodium ethylene diamine tetraacetate, 20% sodium chloride solution, essence, pearlite slurry, carbomer, the alcohol lactate of C12 ~ 13, citric acid, deionized water.The pet can effectively improve the cleaning dynamics of pet hair with eucalyptus oil shampoo, the traditional Chinese medicine ingredients in shampoo are helped to penetrate into skin, so as to reach disinfecting mite-removing, purifying skin mucous membrane, prevention trichomadesis effect, it can also prevent the moisture evaporation of animal skin surfaces, holding hair and the lasting water profit of skin are moist, and long-time service can also increase the skin resistance of pet.
Description
Technical field
The present invention relates to a kind of pet eucalyptus oil shampoo and preparation method and application, and in particular to one kind have it is antibacterial, remove
Worm mite killing, cleannes are high but pet skin and permanent hair water can be kept to moisten moist, long-time service and can improve pet skin
Shampoo of resistance and its preparation method and application.
Background technology
Have become the common companion in human lives with pets such as economic rapid development, dog cats, people are to pet
Health also increasingly pay attention to.The U.S. of the first big country of pet in the world, a maximum domestic cat canine pet food enterprise, year sell
Sell volume and be just up to 5,000,000,000 dollars.It was predicted that it will be also incremented by the coming years with the amplitude per year over 6%.China's pet industry rises
Although walking the ability more than ten years, no longer it has been single pet bargain transaction, has further comprises pet grooming, Medical pet, pet clothes
Dress etc..The market potential of China's pets economy can at least reach 15,000,000,000 RMB at this stage.
However, the health problem of pet but allows of no optimist, skin disease is even more to become the biggest problem of puzzlement owner.It is clinical normal
Seeing has dog cat malis, bacterial dermatosis, fungal dermatopathy, allergic skin disease, hormonal skin
Disease, metabolism dermatoses.Can multiple mixed infection after progression of the disease, it may be possible to two kinds or more of cause of disease mixed infections, treatment
Complexity, the course of disease is longer, and therapeutic effect is poor.With malis, fungal dermatopathy, bacillary skin in numerous causes of disease
Skin disease and combination disease are multiple.Clinical common malis is mainly itch mite, vermiform mite and otodectic mange;Draw
Play dog, the cause of disease of cat fungal dermatopathy has microsporum canis, Trichophyton mentagrophytes and gypsum sample pityrosporion ovale;The cause of bacterial dermatosis
Germ 97.0% is osculant staphylococcus, and 2.5% also has the Escherichia coli of secondary infection for staphylococcus aureus, and mixes
The infection of property is then based on acarid and fungal infection.
Traditional shampoo for pets can only fall the Fouling Cleaning with pet, for the more difficult killing of dust mite of carrying, and make
Although can solve the problems, such as the pharmacological property of pet parasite with the shampoo of chemical insecticide, pet can not be avoided to lick and lick skin, medicine
The phenomenon for causing poisoning in vivo is penetrated into through skin, long-time service is also easy to cause drug resistance.CN102085163A discloses one kind
Except mite shampoo for pets, which employs except mite agent N, N ~ bis-(3 ~ aminopropyl)Dodecyl amine(Lonzabac 12.100)Acted on,
Although dirty, the killing dust mite with pet can be washed off, effect is relatively single, and can not solve strong detergency but pet skin
The defects of easily being dried with hair.CN1079776A discloses a kind of dog, cat special-purpose medicaments detergent, selects to person poultry harmless's
Insecticide --- Amitraz, is equipped with surfactant, and the auxiliary material such as fur protective agent and spices pigment is processed to be made, and has and keeps
Pet fur cleaning, bright, soft effect, while the dermatozoons such as mite, flea can be killed, also have one to fungal dermatosis
Fixed therapeutic effect, but Amitraz is used below less than 25 DEG C in temperature, and drug effect plays a role relatively slowly, and drug effect is relatively low, therefore has
Certain limitation.
Based on above-mentioned analysis, a kind of disinfecting mite-removing positive effect, soft non-stimulated, cleaning dynamics is strong, can also prevent animal
The moisture evaporation of skin surface, keeps hair and the lasting water of skin to moisten moist, long-time service and can improve pet skin resistance
Pet with eucalyptus oil shampoo be badly in need of in current industry.
The content of the invention
In view of above-mentioned deficiency, it is an object of the invention to provide one kind cleaning is antibacterial, deinsectization mite killing, soft non-stimulated, clear
Clean dynamics is strong, keeps hair and the pet moist, that long-time service can improve pet skin resistance of the lasting water profit of skin to use eucalyptus
Salted cake fried in sesame oil ripple, has dog cat common skin diseases the effect of prevention and auxiliary treatment.
In order to achieve the above object, present invention employs following technical scheme, the dosage of each component of the present invention is also process
Inventor carries out largely groping to summarize what is drawn, the pet that each component dosage is prepared in the range of following weight eucalyptus oil shampoo
Be respectively provided with antibacterial, the deinsectization mite killing of cleaning, it is soft it is non-stimulated, cleaning dynamics is strong, keeps hair and the lasting water profit of skin moist, long
Phase use can improve the advantage of pet skin resistance.
A kind of pet mainly includes the raw material of following weight with eucalyptus oil shampoo:
1 ~ 3 part of eucalyptus oil, 10 ~ 20 parts of sodium laureth sulfate, 7 ~ 15 parts of lauryl sodium sulfate, dodecyl sweet tea
6 ~ 20 parts of dish alkali, 1 ~ 3 part of lauric acid amide of ethanol, 3 ~ 5 parts of disodium ethylene diamine tetraacetate, 20% sodium chloride solution 0.1 ~ 0.9
Part, 0.1 ~ 0.3 part of essence, 1 ~ 3 part of pearlite slurry, 0.2 ~ 0.4 part of carbomer, C12 ~ 0.3 ~ 0.7 part of 13 alcohol lactate, citric acid are fitted
Amount, appropriate deionized water.
Further, which further includes the raw material of following parts by weight:
0.5 ~ 1 part of Eclipta prostrata extracting solution, 0.5 ~ 1 part of fish pelargonium extracting solution, 0.5 ~ 1 part of beer yeast powder.
Further, which is made of the raw material of following parts by weight:
2 parts of eucalyptus oil, 0.5 part of Eclipta prostrata extracting solution, 0.5 part of fish pelargonium extracting solution, 0.5 part of beer yeast powder, lauryl polyoxy second
15 parts of alkene ether sodium sulfate, 11 parts of lauryl sodium sulfate, 13 parts of empgen BB, 2 parts of lauric acid amide of ethanol, second
The alcohol of 5 parts of edetate disodium, 0.5 part of 20% sodium chloride solution, 0.2 part of essence, 2 parts of pearlite slurry, 0.3 part of carbomer, C12 ~ 13
0.5 part of lactate, appropriate citric acid, 50 parts of deionized water.
Further, the Eclipta prostrata extracting solution comprises the following steps:
Eclipta prostrata dry product is rinsed well with flowing clear water, pulls out and drains, stripping and slicing, adds in mixer and crush 3 ~ 5 minutes, add 8
20% ethanol of amount again, is extracted 4 ~ 5 times, is merged extracting solution and is simultaneously filtered, then filtrate is recovered under reduced pressure in Vacuum film evaporation instrument
Ethanol, it is 1.05 ~ 1.08 to be concentrated into relative density, obtains Eclipta prostrata extracting solution.
Further, the fish pelargonium extracting solution comprises the following steps:
Take fish pelargonium to be beaten, add 3 ~ 5 times of amounts, when temperature is that 55 ~ 65 DEG C of distillation flooding 3 ~ 5 is small, filtering, filtrate is concentrated into phase
It is 1.01 ~ 1.10 to density, fish pelargonium extracting solution is made.
Further, which is comprised the following steps with eucalyptus oil shampoo preparation method:
(1)The deionized water for weighing recipe quantity is heated to 60 DEG C ~ 65 DEG C in beaker, adds the ethylenediamine tetra-acetic acid two of recipe quantity
Sodium, reduces temperature to 40 DEG C, sequentially adds laurate polyethenoxy ether sodium sulfate, lauryl sodium sulfate, stirs to completely molten
Xie Hou, keeps 40 DEG C of temperature to add empgen BBs and lauric acid amide of ethanol, stirs evenly, keep 40 DEG C of temperature according to
Secondary addition pearlite slurry, 20% sodium chloride solution;
(2)Treat that temperature is down to room temperature, add eucalyptus oil, Eclipta prostrata extracting solution, fish pelargonium extracting solution, beer yeast powder, then add successively
Enter the alcohol lactate of C12 ~ 13, essence, carbomer, pH to 6.5 ~ 8.5 adjusted with 50% citric acid solution, stir it is uniform to system, it is quiet
Finished product can be obtained by putting.
The invention has the advantages that:
1st, preparation process is simple, and materials are extensive, of low cost, workable, environmentally friendly, are suitable for industrialized popularization
Using.
2nd, effectively softening pet skin cutin, purifying skin mucous membrane, allow active ingredient in eucalyptus oil, radix rehmanniae recen and fish pelargonium
Skin is rapidly permeated into, reaches antibacterial, except mite, desinsection, calmness and other effects, while forms skin sparing film, accelerates the new old of skin
Metabolism, prevents the formation of worm mite for a long time.
3rd, the not material such as silicate-containing oil, guar gum, will not block the pore of pet, reduce the symptoms such as hair loss, depilation.In eucalyptus oil
With under the collective effect of beer yeast powder, pinning skin and the moisture of hair surface, allowing pet to keep hair after using shampoo
Send out submissive and do not knot, while a variety of nutriments in beer yeast powder can recover the glossiness of pet hair.
4th, formula of the invention and technique are inseparable, mutually collaboration, are an indispensable integrated artistics, only exist
Under inventive formulation and process conditions, each raw material could be balanced well so that entered eucalyptus oil, Eclipta prostrata extracting solution, fish pelargonium and carried
Take liquid, beer yeast powder synergistic, draw strong detergency, the resistance of skin can not only be strengthened, moreover it is possible to keep skin and hair
Sending out water permanent, profit is moist, and long-time service can also improve pet skin resistance.
Embodiment
We will the invention will be further elaborated with reference to embodiment below.
Embodiment 1
Pet eucalyptus oil shampoo
(1)Prepare Eclipta prostrata extracting solution:Eclipta prostrata dry product is rinsed well with flowing clear water, pulls out and drains, stripping and slicing, adds stirring
Crushed 4 minutes in machine, add 8 times of 20% ethanol of amount, extract 5 times, merge extracting solution and filter, then steam filtrate in vacuum film
Ethanol is recovered under reduced pressure in hair instrument, it is 1.06 to be concentrated into relative density, obtains Eclipta prostrata extracting solution.
(2)Prepare fish pelargonium extracting solution:Take fish pelargonium to be beaten, add 4 times of amounts, when temperature is that 60 DEG C of distillation flooding 4 is small,
Filtering, it is 1.05 that filtrate, which is concentrated into relative density, and fish pelargonium extracting solution is made.
(3)Weigh 50kg deionized waters and 62.5 DEG C are heated in beaker, add 5kg disodium ethylene diamine tetraacetates, reduce
Temperature sequentially adds 15kg laurate polyethenoxy ether sodium sulfate, 11kg lauryl sodium sulfate to 40 DEG C, stirs to completely molten
Xie Hou, keeps 40 DEG C of temperature to add 13kg empgen BBs and 2kg lauric acid amide of ethanol, stirs evenly, keep temperature
40 DEG C of degree sequentially adds 2kg pearlite slurries, 20% sodium chloride solutions of 0.5kg;
(2)Treat that temperature is down to room temperature, add 2kg eucalyptus oil, 0.5kg Eclipta prostratas extracting solution, 0.5kg fish pelargoniums extracting solution, 0.5kg beers
Brewer yeast powder, sequentially adds the alcohol lactate of 0.5kg C12 ~ 13,0.2kg essence, 0.3kg carbomers, with 50% citric acid solution
PH to 7.5 is adjusted, stirs uniform to system, standing can obtain finished product.
Embodiment 2
Pet eucalyptus oil shampoo
Preparation process is made with embodiment 1, simply shampoo of the raw material of following weight:
Eucalyptus oil 1kg, sodium laureth sulfate 10kg, lauryl sodium sulfate 7kg, empgen BB 6kg,
Lauric acid amide of ethanol 1kg, disodium ethylene diamine tetraacetate 3kg, 20% sodium chloride solution 0.1kg, essence 0.1kg, pearlite slurry
1kg, the alcohol lactate 0.3kg of carbomer 0.2kg, C12 ~ 13, citric acid solution adjust pH to 6.5, deionized water 60kg.
Embodiment 3
Pet eucalyptus oil shampoo
Preparation process is made with embodiment 1, simply shampoo of the raw material of following weight:
Eucalyptus oil 3kg, Eclipta prostrata extracting solution 1kg, fish pelargonium extracting solution 1kg, beer yeast powder 1kg, laureth sulphur
Sour sodium 20kg, lauryl sodium sulfate 15kg, empgen BB 20kg, lauric acid amide of ethanol 3kg, ethylenediamine tetraacetic
Acetic acid disodium 5kg, 20% sodium chloride solution 0.9kg, essence 0.3kg, pearlite slurry 3kg, the alcohol lactate of carbomer 0.4kg, C12 ~ 13
0.7kg, citric acid solution adjust pH to 8.5, deionized water 40kg.
Test example 1
Pet eucalyptus oil shampoo(Beer yeast powder is not added compared to embodiment 1)
Test example 2
Pet eucalyptus oil shampoo(Eucalyptus oil is not added compared to embodiment 1)
Performance test
Choose embodiment 1 and the eucalyptus oil shampoo of each test example be tested for the property, each product packaging is placed at 30 ~ 35 DEG C,
Constant temperature is placed 2 weeks, then is placed in 24h at 0 ~ 10 DEG C, and product is not any change.The test of its skin effect is as follows:Randomly select 50 2
Year cat, 50 2 years old dogs, 100 pets are randomly divided into 5 groups, every group of 10 cats add 10 dogs, respectively using embodiment 1, experiment
The shampoo for pets of example 1,2 is cleaned, 3 days 1 time, persistently using 3 months, is observed every group of pet and is used the hair after shampoo 3 months
Hair quality, soil removal efficiency, hair loss situation, dermopathic probability occurs, as a result such as table 1.
1 properties of product test data of table
。
Can be seen that by table 1, long-time service embodiment 1, the shampoo for pets of embodiment 3 have to the hair of pet it is submissive,
Shui Run, the effect easily combed, are also less prone to hair loss, and dermopathic probability, which occurs, using pet after 3 months is no more than 10%.It is and real
Apply and Eclipta prostrata extracting solution, fish pelargonium extracting solution and beer yeast powder are eliminated in example 2, detergency is slightly below embodiment after use
1 and 3, while skin disease incidence is higher than embodiment 1 and 3.Test example 1 combs difficulty after use, easily knots, the 2nd day just
Occur greasy, easy hair loss in daily life, effect is worst not as good as clean effect, and it is 30% that dermopathic probability, which occurs, in it, significantly low
In embodiment 1 and 3.Test example 2 washes rear hair and slightly knots after use, is easier to comb, hair is omitted in daily life, after use
2nd day hair non-greasy, 3 middle of the month skin disease incidences are 40%, although cleannes reach 85%, skin disease incidence is five
It is minimum in item experiment.Illustrate only in the common of addition eucalyptus oil, Eclipta prostrata extracting solution, fish pelargonium extracting solution and beer yeast powder to make
With lower the fluffy, submissive of pet hair, water could be maintained to moisten, while the cleaning to pet skin pore has facilitation, is not easy
Hair loss, moreover it is possible to reduce the probability of animal suffering from skin disease.
Insecticidal effect is tested
Eucalyptus oil shampoo to embodiment 1 and each test example tests its insecticidal effect using the medicine dipping method of standard, first passes through pre-
Experiment determines general concentration range, and all shampoo for pets are half-and-half diluted with distilled water, and in test every group of boophilus microplus be not
Suck blood young tick 10, often handle 3 repetitions.Absorption 1ml shampoos dilution addition boophilus microplus is not sucked blood in young tick, and dipping 5s ~
10min, medicine is suctioned out, and the shampoo dilution of dry tick body surface is wiped with filter paper, and being transferred to bottom has in the drying basin of water, room temperature,
Relative humidity is maintained at 80 ~ 85%.After 24h, its death condition is observed.Judge that dead boophilus microplus is not sucked blood children with following procedure
Tick:First, directly observing, each limb of boophilus microplus is inactive;Second, under anatomical lens, each limb activity of boophilus microplus is not seen;Third,
Toothpick gentle touchdown is used under anatomical lens, does not also see each limb activity of boophilus microplus.Improved mortality formula:Death rate %=(Extremely
Die tick borer population/experiment tick borer population)×100%.It is shown in Table 2.
2 each group shampoo of table compares the killing effect of ox tick
。
Can be seen that the tick worm death rate reachable more than 90% of embodiment 1 and test example 3 by table 2, insecticidal effect is notable,
Eclipta prostrata extracting solution, fish pelargonium extracting solution and the beer yeast powder tick worm death rate are not added with embodiment 2 and drops to 76.7%, slightly
Less than embodiment 1 and 3.Be not added with beer yeast powder in test example 1, the tick worm death rate is 80.0%, be substantially less than embodiment 1 with
3, the tick worm death rate in test example 2 is 60.0%, also slightly below test example 1, and illustrating the addition of eucalyptus oil has extremely insecticidal effect
Important effect is closed, while Eclipta prostrata extracting solution, fish pelargonium extracting solution can promote the metabolism of skin with beer yeast powder, it is soft
Change skin keratin, enhancing skin is a kind of inseparable formula to the assimilation effect of medicine.
The extracorporeal bacteria inhibitor test of pet eucalyptus oil shampoo
Picking is brought back to life and in the bacterial clump on Mai Kangkai culture mediums after purification in nutrient broth, 37 DEG C of culture 18h, with nothing
Bacterium solution is diluted to equivalent to 0.5 Maxwell than turbid standard by bacterium physiological saline(1×108CFU/ parts), then sterile vegetative meat soup is final
10 times to 2 × 10 of dilution5CFU parts~1.Precision weighing medicine to be measured, is put into polypropylene centrifuge tube, makes the eucalyptus oil shampoo concentration be
62.48 mg/ parts.The bacterium solution of 100 μ L is respectively added using the hole of the l in 96 sterile hole plates of micro meat soup normal direction ~ 8,8 holes are not added with
Bacterium solution and add 100 μ L nutrient broths.Then corresponding 100 μ L of medicine to be measured are added from l holes, 2 times is carried out and is diluted to 7 holes, 9 holes
Medicine is not added with as control wells, 37 DEG C of 90r/min cultivate 18 ~ 24h, and every group is done 3 repetitions and tested.
10 μ L0.25%TTC are added after 18h per hole, continues to cultivate 2h, red is shown if having viable bacteria, judges MIC.Will after 18h
There is no being seeded on tablet for long bacterium to place 24h again in hole, interpretation observation MBC.
Result of the test shows:Eucalyptus oil shampoo is 1.95mg/ parts to the MIC value of Escherichia coli, and MBC is 3.91mg/ parts;Eucalyptus oil
Shampoo is 0.98mg/ parts to the MIC value of staphylococcus aureus, and MBC is 1.95mg/ parts.
The pet external Fungistasis of eucalyptus oil shampoo
Distinguish from preservation of bacteria strain pipe picking l blocks microsporum canis, gypsum sample pityrosporion ovale and whisker moss bacterium bacterium colony (about lmm ×
1mm), it is put into disinfection mortar, adds 0.5 part of physiological saline, is ground into fungi suspension, then it is close with physiological saline adjustment bacterium solution
Spend l × 105/ part ~ 1 × 106/ part.Control tube and developmental tube are put in 28 DEG C of insulating boxs per Guan Junyong methods of scoring inoculation l platinum loops
Culture, daily observation experiment result.Observe 7d after, with have it is sterile be grown to criterion, with control group (colony growth is normal)
Compare, it is no bacteriostasis to have naked eyes visible colonies life elder, and the medicine least concentration of the sterile elder that is born is the minimum of medicine
Mlc (MIC).By the colony inoculation that above-mentioned culture is not grown to fluid nutrient medium, continue to be incubated 12d, daily observation experiment
As a result.After observing 12d, if fluid nutrient medium is muddy, fungi growth is indicated, fluid nutrient medium is limpid, indicates no fungi life
Long, the concentration in fluid nutrient medium still without fungi growth is judged as the MFC of medicine.
Result of the test shows:Pet has good inhibition with eucalyptus oil shampoo to 3 kinds of Common fungi pathogens of skin disease,
Wherein shampoo be respectively 0.98mg/ parts to the MIC value of microsporum canis, gypsum sample pityrosporion ovale and whisker moss bacterium, 1.95mg/ parts,
0.98mg/ parts, MFC values are respectively 1.95mg/ parts, 3.91mg/ parts, 1.95mg/ parts.
Pet is tested with the external mite killing of eucalyptus oil shampoo
Pet is configured to eucalyptus oil shampoo with deionized water to 500mg/ parts of concentration, then etc. ratio be diluted to 5 concentration step by step
(500 to 31.25mg/ parts, r=2), distilled water is as a control group.Picking itch mite larva is placed in small plate(Diameter 5cm)In, with
Machine is divided into 6 groups, every group 20,3 repetitions, and laboratory reference Fichi's etc. soaks the method killed in vitro, and each culture dish adds liquid
10 μ L, then will cultivate, microscopy death condition after 12h under all 25 DEG C of plates, 75% relative humidity.
Eucalyptus oil shampoo is diluted with distilled water into 500mg/ parts, three 250mg/ parts, 125mg/ parts concentration, distilled water conduct
Control group.Picking itch mite larva is placed in small plate(Diameter 5cm)In, it is randomly divided into 4 groups, every group 20,3 repetitions, Ran Houjia
Enter each 10 μ L of concentration liquid.Then it will be cultivated under all 25 DEG C of plates, 75% relative humidity, observe and record at regular intervals
Itch mite death condition, until all tested itch mites are dead.
Result of the test shows:Pet is with eucalyptus oil shampoo in the external acaricidal activity experiment of psoroptes cuniculi, eucalyptus oil shampoo is to itching
The LC of mite 12h50For 75.86mg/ parts, under 500mg/ parts of shampoo concentration, it is measured to psoroptes cuniculi larva by soaking the mode of killing
In vitro acaricidal activity when, LD50 time LT50For 5.23h.Pet has in vitro acarid with eucalyptus oil shampoo certain
Suppression killing effect, the prevention and treatment available for dog cat mite disease.
Learnt by above-mentioned experiment, pet with eucalyptus oil shampoo to Escherichia coli, staphylococcus aureus, microsporum canis,
Gypsum sample pityrosporion ovale and the antibacterial effect of whisker moss bacterium are obvious, and pet has necessarily in vitro acarid with eucalyptus oil shampoo in addition
Suppress killing effect, the prevention and treatment available for dog cat mite disease.
In conclusion the formula and technique of the present invention are inseparable, mutually collaboration, is indispensable one overall work
Skill, only under the formula of the present invention, which could preferably soften pet skin cutin, and purifying skin mucous membrane, allows
Active ingredient in eucalyptus oil, Eclipta prostrata and fish pelargonium rapidly permeates into skin, reaches antibacterial, except mite, desinsection, calmness and other effects, together
When form skin sparing film, accelerate the metabolism of skin, prevent the formation of worm mite for a long time.It should be appreciated that to ability
For the those of ordinary skill of domain, it can according to the above description be improved or be converted, and all these modifications and variations should all belong to
In the protection domain of appended claims of the present invention.
Claims (6)
1. a kind of pet eucalyptus oil shampoo, it is characterised in that the eucalyptus oil shampoo mainly includes the raw material of following weight:Eucalyptus
1 ~ 3 part of oil, 10 ~ 20 parts of sodium laureth sulfate, 7 ~ 15 parts of lauryl sodium sulfate, empgen BB 6 ~
20 parts, 1 ~ 3 part of lauric acid amide of ethanol, 3 ~ 5 parts of disodium ethylene diamine tetraacetate, 0.1 ~ 0.9 part of 20% sodium chloride solution, essence
0.1 ~ 0.3 part, 1 ~ 3 part of pearlite slurry, 0.2 ~ 0.4 part of carbomer, C12 ~ 0.3 ~ 0.7 part of 13 alcohol lactate, appropriate citric acid, go from
Sub- appropriate amount of water.
2. pet according to claim 1 eucalyptus oil shampoo, it is characterised in that the eucalyptus oil shampoo further includes following parts by weight
Raw material:0.5 ~ 1 part of Eclipta prostrata extracting solution, 0.5 ~ 1 part of fish pelargonium extracting solution, 0.5 ~ 1 part of beer yeast powder.
3. pet according to claim 2 eucalyptus oil shampoo, it is characterised in that the eucalyptus oil shampoo by following parts by weight original
Material composition:2 parts of eucalyptus oil, 0.5 part of Eclipta prostrata extracting solution, 0.5 part of fish pelargonium extracting solution, 0.5 part of beer yeast powder, lauryl polyoxy
15 parts of ethene ether sodium sulfate, 11 parts of lauryl sodium sulfate, 13 parts of empgen BB, 2 parts of lauric acid amide of ethanol,
5 parts of disodium ethylene diamine tetraacetate, 0.5 part of 20% sodium chloride solution, 0.2 part of essence, 2 parts of pearlite slurry, 0.3 part of carbomer, C12 ~ 13
0.5 part of alcohol lactate, appropriate citric acid, 50 parts of deionized water.
4. the pet eucalyptus oil shampoo according to Claims 2 or 3, it is characterised in that the Eclipta prostrata extracting solution is by as follows
Method is made:Eclipta prostrata dry product is rinsed well with flowing clear water, pulls out and drains, stripping and slicing, adds and 3 ~ 5 points are crushed in mixer
Clock, adds 8 times of 20% ethanol of amount, extracts 4 ~ 5 times, merge extracting solution and filter, then subtract filtrate in Vacuum film evaporation instrument
Receipts ethanol is pushed back, it is 1.05 ~ 1.08 to be concentrated into relative density, obtains Eclipta prostrata extracting solution.
5. the pet eucalyptus oil shampoo according to Claims 2 or 3, it is characterised in that the fish pelargonium extracting solution is by as follows
Method is made:Take fish pelargonium to be beaten, add 3 ~ 5 times of amounts, when temperature is that 55 ~ 65 DEG C of distillation flooding 3 ~ 5 is small, filter, filtrate is dense
It is 1.01 ~ 1.10 to be reduced to relative density, and fish pelargonium extracting solution is made.
A kind of 6. preparation method according to any pet eucalyptus oil shampoo of claim 1 ~ 4, it is characterised in that the preparation
Method comprises the following steps:
(1)The deionized water for weighing recipe quantity is heated to 60 DEG C ~ 65 DEG C in beaker, adds the ethylenediamine tetra-acetic acid two of recipe quantity
Sodium, reduces temperature to 40 DEG C, sequentially adds laurate polyethenoxy ether sodium sulfate, lauryl sodium sulfate, stirs to completely molten
Xie Hou, keeps 40 DEG C of temperature to add empgen BBs and lauric acid amide of ethanol, stirs evenly, keep 40 DEG C of temperature according to
Secondary addition pearlite slurry, 20% sodium chloride solution;
(2)Treat that temperature is down to room temperature, add eucalyptus oil, Eclipta prostrata extracting solution, fish pelargonium extracting solution, beer yeast powder, then add successively
Enter the alcohol lactate of C12 ~ 13, essence, carbomer, pH to 6.5 ~ 8.5 adjusted with 50% citric acid solution, stir it is uniform to system, it is quiet
Finished product can be obtained by putting.
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