CN107913234A - A kind of savatier monochasma herb toothpaste and preparation method thereof - Google Patents
A kind of savatier monochasma herb toothpaste and preparation method thereof Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
It is composed of the following components in parts by weight the present invention provides a kind of savatier monochasma herb toothpaste：36 parts of Herba monochasmatis extract, 24 parts of Herba Lophatheri extract, 24 parts of mint extract, 73 86 parts of toothpaste matrix.The savatier monochasma herb toothpaste has good inhibiting bacteria and diminishing inflammation and analgesic efficacy, since the suppression to pathogenic bacteria is with strong points, has preferable oral restoration ability；Meanwhile the toothpaste also has good therapeutic effect to the oral cavity life oral inflammation such as sore and swelling and aching of gum, scientific formulation is simple, cost of material is low, cost-effective.Present invention also offers the preparation method of the savatier monochasma herb toothpaste, preparation method is simply easy to operate, fully can extract and protect effective restraining and sterilizing bacteria component in savatier monochasma herb and lophatherum gracile.
Description
Technical field
The present invention relates to oral care and the technical field of health care, more particularly, to a kind of savatier monochasma herb toothpaste and its preparation side
Method.
Background technology
Oral inflammation mainly includes exedens, herpetic and mycotic stomatitis, and lichen planus of mouth etc..Various mouths
The chamber inflammation and possibility deposited is very big.Wherein, pathogenic process of re current rate is higher, it has periodicity, recurrent, limits certainly
The feature of property.Serious canker sore patient is also possible to complication such as swelling and aching of gum, bleeding gums.
With the enhancing of people's health consciousness and the raising of quality of the life, more and more consumer orientations have in use
Certain function, the effect of solving the problems, such as and improving the oral inflammations such as canker sore type toothpaste, and contain extracted form natural plant
The Chinese herbal toothpaste of thing because it is warm-natured, stimulate small and safe and non-toxic welcome be subject to consumers in general.
In Chinese medicine class toothpaste in existing market, the Chinese medicine species of a part of toothpaste is more single, has not given play to traditional Chinese medicine
The synergistic effect that the mutual compatibility of material produces；A part is that contained prescriptions of traditional Chinese medicine taste number is too many, causes component composition complicated, makes in tooth
Original content is lower with regard to limited active constituent content in cream.In addition, antibiotic effective ingredient specific aim used in these toothpaste
It is not strong, there is the antibiotic property of wide spectrum, i.e. the resident bacteria of counterpart intracavitary non-pathogenic also produces inhibitory action, reduces oral cavity and respectively organizes
To the self-healing ability of damage.
Therefore, it is necessary to develop a kind of formula simply, and it can safely and effectively prevent and treat the Chinese medicine of oral inflammation
Toothpaste.
The content of the invention
In order to solve the above problem existing in the prior art, the present invention provides one kind based on savatier monochasma herb, lophatherum gracile is
It is auxiliary, while the savatier monochasma herb toothpaste of peppermint is with the addition of, which has good inhibiting bacteria and diminishing inflammation and analgesic efficacy, due to pathogenic bacteria
Suppression it is with strong points, there is preferable oral restoration ability；Meanwhile the toothpaste gives birth to the stomatitis such as sore and swelling and aching of gum to oral cavity
Disease also has good therapeutic effect, and scientific formulation is simple, cost of material is low, cost-effective.
To achieve these goals, the present invention provides following technical solution：
A kind of savatier monochasma herb toothpaste, it is composed of the following components in parts by weight：3-6 parts of Herba monochasmatis extract, Herba Lophatheri extract 2-4
Part, 2-4 parts of mint extract, 73-86 parts of toothpaste matrix.
As further describing for technical scheme, the toothpaste matrix is in parts by weight by following components group
Into：27-32 parts of rubbing agent, 14-17 parts of excipient, 28-31 parts of moisturizer, 1.2-1.6 parts of thickener, 0.5-1.1 parts of essence, hair
1.3-1.8 parts of infusion, 1.0-1.5 parts of sweetener.
It is composed of the following components in parts by weight as further describing for technical scheme：Savatier monochasma herb extracts
3 parts of thing, 2 parts of Herba Lophatheri extract, 2 parts of mint extract, 80 parts of toothpaste matrix；
The toothpaste matrix is composed of the following components in parts by weight：
30 parts of rubbing agent, 15 parts of excipient, 30 parts of moisturizer, 1.4 parts of thickener, 0.8 part of essence, 1.6 parts of foaming agent, sweetener
1.2 part.
As further describing for technical scheme, in the toothpaste matrix, the rubbing agent for silica,
One or any several mixture in calcium carbonate, calcium bicarbonate and calcium phosphate dibasic dihydrate；The excipient is sorb
Sugar alcohol；The moisturizer is one or any several mixture in glycerine, propane diols, polyethylene glycol and sorbierite；Institute
It is silica to state thickener；The essence is any one in Mint Essence, leaf of bamboo essence, spearmint essence and strawberry essence
Kind；The foaming agent sldium lauryl sulfate；The sweetener is saccharin sodium or Aspartame.
In the present invention, savatier monochasma herb is the drying herb of Scrophulariaceae savatier monochasma herb platymiscium wool savatier monochasma herb, and Classification system is
Monochasma savatieri Franch, alias Chinese mugwort, thousandweight tower, Chinese alpine rush, the Chinese bulbul etc. in thousand, have thermal detoxification, cool blood
Hemostasis and other effects, clinic are mainly used for treatment flu, cough, spit blood, infection of the upper respiratory tract etc., are that Chinese medicine protection kind is peaceful scorching
One of main component of grain.Inventor has found under study for action, and benzyl carbinol glycosides are rich in the water extract of savatier monochasma herb, contain phase at the same time
Chlorogenic acid, saponin(e and the flavone compound answered, the good antimicrobial effect of this kind of compound.Research finds, savatier monochasma herb aqueous solution
In extract, the benzyl carbinol glycosides of savatier monochasma herb are to staphylococcus aureus, pseudomonas aeruginosa, Escherichia coli and helicobacter pylori
With very strong antibacterial activity.Researcher thinks that antibacterial/antimicrobial acivity of savatier monochasma herb benzyl carbinol glycosides is attributed to phenolic hydroxyl group
It is in close relations between protein, therefore in prepared by the savatier monochasma herb toothpaste of the present invention, its benzene second is can ensure that in water extraction process
The phenolic hydroxyl group of alcohol glycosides is protected, and avoids introducing organic solvent from destroying the phenolic hydroxyl group.
Lophatherum gracile is the cauline leaf of grass family herbaceos perennial, and Classification system is Lophatherum gracile, alias
Common lophatherum rhizome and root, pheasant rice, golden pheasant rice, Herba Lophatheri etc., its slightly sweet flavor is cold in nature, nontoxic, has the work(such as clearing heat and relieving fidgetness, diuresis, agitation of dispelling
Effect, and have unique curative effect to aphthae, commonly use its cauline leaf and make decoction, for treating swelling and aching of gum, stomatitis etc..Inventor
Find under study for action, terpenes, alkaloid, flavonoids, the amino acid and polysaccharide of uniqueness contained in the water extract of lophatherum gracile
With good antibacterial activity, especially containing substantial amounts of flavone compound and bioactive polysaccharide to Staphylococcus aureus
Bacterium and hemolytic streptococcus have good inhibitory action.
Peppermint is Labiatae mint, and Classification system is Mentha haplocalyx Briq, is that China is common
One of traditional Chinese medicine, and a kind of important spice berry, its main component are menthol.Peppermint has dispelling wind, heat dissipation, removing toxic substances
The effect of, for treating anemopyretic cold, headache, hot eyes, abscess of throat and toothache etc., addition peppermint can make implication clear in toothpaste
Newly.
Being compounded savatier monochasma herb water extract and Herba Lophatheri extract of the invention, strengthens to oral cavity pathogen
Suppression and killing effect, especially to the staphylococcus aureus for causing canker sore symptom and the suppression of helicobacter pylori and
Killing effect is notable；Meanwhile savatier monochasma herb can stop blooding, promote the healing of the oral inflammation surface of a wound, effectively relieve pain.Savatier monochasma herb and light
Both leaf of bamboves are synergistic, and especially savatier monochasma herb benzyl carbinol glycosides and lophatherum gracile active polysaccharide cooperate, and have preferable oral cavity
Repair ability, also there is good treatment to imitate oral cavity life sore and swelling and aching of gum etc. oral inflammation.
With the addition of peppermint prescription in the savatier monochasma herb toothpaste, peppermint has antipathogenic composition and curative effect, can play alleviation toothache,
The effect of gum is nourished, while peppermint can solve oral cavity Dead Core Problems, can remove implication, the halitosis improved for a long time is asked
Topic.
In the toothpaste matrix of the present invention, by rubbing agent, excipient, moisturizer, thickener, essence, foaming agent and sweet taste
Agent forms, and by the ratio of preferred above-mentioned matrix components, makes it as savatier monochasma herb, lophatherum gracile and the carrier of peppermint so that raw material
In traditional Chinese medicinal components can be fully miscible so that lotion becomes fine and smooth, compacts, bright, distribution of color is uniform, further carry
The quality of lotion is risen.
As another object of the present invention, present invention also offers the preparation method of above-mentioned savatier monochasma herb toothpaste, specifically
Step is as follows：
（1）Add pure water to decoct twice respectively savatier monochasma herb, lophatherum gracile and peppermint respectively, when each decocting time is 1.5 small, close
And decoction liquor, filtering, and it is paste to be concentrated and dried, and respectively obtains Herba monochasmatis extract, Herba Lophatheri extract and peppermint extraction
Thing；
（2）According to 3-6 parts of Herba monochasmatis extract, 2-4 parts of Herba Lophatheri extract, 2-4 parts of mint extract, toothpaste matrix 73-86
The parts by weight of part, by Herba monochasmatis extract, Herba Lophatheri extract and the mint extract obtained by step 1, and toothpaste matrix
It is conveyed into de-airing mixer to be stirred and homogeneous, obtains lotion；The time of the stirring and homogeneous is 20-30 minutes；
（3）After carrying out sterilization treatment to lotion, packed with composite soft tube and obtain savatier monochasma herb toothpaste.
In the preparation method, the present invention fully extracts and protects effective restraining and sterilizing bacteria group in savatier monochasma herb and lophatherum gracile
Point, this has significant suppression for the staphylococcus aureus and helicobacter pylori for causing canker sore symptom and kills work
With.
Based on above-mentioned technical solution, the technique effect that the present invention obtains is：
（1）Savatier monochasma herb toothpaste provided by the invention, by the water extract to savatier monochasma herb, lophatherum gracile and peppermint these three Chinese medicines into
Row reasonable compatibility, its active ingredient and mechanism of action are all relatively clearer and more definite, which has good inhibiting bacteria and diminishing inflammation and analgesic efficacy,
There is less inhibitory action since the suppression to pathogenic bacteria is with strong points, and to the resident bacteria of non-pathogenic, so as to effectively carry
Self-healing ability and oral restoration ability of the high oral cavity tissue to damage.
（2）The savatier monochasma herb toothpaste of the present invention, can promote the healing of the oral inflammation surface of a wound, therefore swell to oral cavity life sore and gum
The oral inflammations such as pain also have good therapeutic effect, its scientific formulation is simple, cost of material is low, cost-effective.With it is traditional
The medicated toothpaste for the treatment of canker sore is compared, few side effects, security higher.
（3）Savatier monochasma herb toothpaste preparation method provided by the invention, can fully extract and protect in savatier monochasma herb and lophatherum gracile
Effective antibacterial and bactericidal component, it is ensured that the active ingredient in toothpaste can play suppression and the killing effect to pathogenic bacteria so that
Effectively prevention and treatment oral inflammation.In the preparation method, cost of material is low, work that is easy to operate and not influencing traditional Chinese medicinal components
Property, processing step is few, beneficial to industrialized production.
Embodiment
For the ease of understanding the present invention, the present invention is described more fully below in conjunction with specific embodiments.This
Invent the better embodiment given.But the present invention can realize in many different forms, however it is not limited to this paper institutes
The embodiment of description.On the contrary, the purpose for providing these embodiments is to make to understand more the disclosure
Thorough and comprehensive.
Unless otherwise defined, all of technologies and scientific terms used here by the article is with belonging to technical field of the invention
The normally understood implication of technical staff is identical.Term used in the description of the invention herein is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.
Embodiment 1
A kind of savatier monochasma herb toothpaste, it is composed of the following components in parts by weight：3 parts of Herba monochasmatis extract, 2 parts of Herba Lophatheri extract,
2 parts of mint extract, 80 parts of toothpaste matrix；
Wherein, toothpaste matrix is composed of the following components in parts by weight：
30 parts of rubbing agent silica, 15 parts of excipient D-sorbite, 30 parts of moisturizer polyethylene glycol, thickener-silica
1.4 parts, 0.8 part of essence leaf of bamboo essence, 1.6 parts of foaming agent sldium lauryl sulfate, 1.2 parts of sweetener Aspartame.
The toothpaste of the present embodiment is made by following preparation method, is concretely comprised the following steps：
（1）Add pure water to decoct twice respectively savatier monochasma herb, lophatherum gracile and peppermint respectively, when each decocting time is 1.5 small, close
And decoction liquor, filtering, and it is paste to be concentrated and dried, and respectively obtains Herba monochasmatis extract, Herba Lophatheri extract and peppermint extraction
Thing.
（2）According to 3 parts of Herba monochasmatis extract, 2 parts of Herba Lophatheri extract, 2 parts of mint extract, the weight that 80 parts of toothpaste matrix
Number is measured, Herba monochasmatis extract, Herba Lophatheri extract and the mint extract obtained by step 1, and toothpaste matrix are conveyed into
De-airing mixer is stirred and homogeneous, obtains lotion；The time of stirring and homogeneous is 26 minutes.
（3）After carrying out sterilization treatment to lotion, the savatier monochasma herb toothpaste for obtaining embodiment 1 is packed with composite soft tube.
Embodiment 2
A kind of savatier monochasma herb toothpaste, it is composed of the following components in parts by weight：5 parts of Herba monochasmatis extract, 3 parts of Herba Lophatheri extract,
3 parts of mint extract, 82 parts of toothpaste matrix；
Wherein, toothpaste matrix is composed of the following components in parts by weight：
31 parts of rubbing agent calcium phosphate dibasic dihydrate, 15 parts of excipient D-sorbite, 31 parts of moisturizer glycerine, thickener-silica
1.4 parts, 0.8 part of essence Mint Essence, 1.6 parts of foaming agent sldium lauryl sulfate, 1.2 parts of sweetener saccharin sodium.
The toothpaste of the present embodiment is made by following preparation method, is concretely comprised the following steps：
（1）Add pure water to decoct twice respectively savatier monochasma herb, lophatherum gracile and peppermint respectively, when each decocting time is 1.6 small, close
And decoction liquor, filtering, and it is paste to be concentrated and dried, and respectively obtains Herba monochasmatis extract, Herba Lophatheri extract and peppermint extraction
Thing.
（2）According to 5 parts of Herba monochasmatis extract, 3 parts of Herba Lophatheri extract, 3 parts of mint extract, the weight that 82 parts of toothpaste matrix
Number is measured, Herba monochasmatis extract, Herba Lophatheri extract and the mint extract obtained by step 1, and toothpaste matrix are conveyed into
De-airing mixer is stirred and homogeneous, obtains lotion；The time of stirring and homogeneous is 20 minutes.
（3）After carrying out sterilization treatment to lotion, the savatier monochasma herb toothpaste for obtaining embodiment 2 is packed with composite soft tube.
Embodiment 3
A kind of savatier monochasma herb toothpaste, it is composed of the following components in parts by weight：6 parts of Herba monochasmatis extract, 4 parts of Herba Lophatheri extract,
4 parts of mint extract, 86 parts of toothpaste matrix；
Wherein, toothpaste matrix is composed of the following components in parts by weight：
32 parts of rubbing agent silica, 17 parts of excipient D-sorbite, 31 parts of moisturizer sorbierite, thickener-silica 1.6
Part, 1.1 parts of essence leaf of bamboo essence, 1.8 parts of foaming agent sldium lauryl sulfate, 1.5 parts of sweetener Aspartame.
The toothpaste of the present embodiment is made by following preparation method, is concretely comprised the following steps：
（1）Add pure water to decoct twice respectively savatier monochasma herb, lophatherum gracile and peppermint respectively, when each decocting time is 1.7 small, close
And decoction liquor, filtering, and it is paste to be concentrated and dried, and respectively obtains Herba monochasmatis extract, Herba Lophatheri extract and peppermint extraction
Thing.
（2）According to 6 parts of Herba monochasmatis extract, 4 parts of Herba Lophatheri extract, 4 parts of mint extract, the weight that 86 parts of toothpaste matrix
Number is measured, Herba monochasmatis extract, Herba Lophatheri extract and the mint extract obtained by step 1, and toothpaste matrix are conveyed into
De-airing mixer is stirred and homogeneous, obtains lotion；The time of stirring and homogeneous is 30 minutes.
（3）After carrying out sterilization treatment to lotion, the savatier monochasma herb toothpaste for obtaining embodiment 3 is packed with composite soft tube.
Reference examples 1（Not comprising Herba Lophatheri extract component）
A kind of toothpaste, it is composed of the following components in parts by weight：3 parts of Herba monochasmatis extract, 2 parts of mint extract, toothpaste matrix
80 parts；
Wherein, toothpaste matrix is composed of the following components in parts by weight：
30 parts of rubbing agent silica, 15 parts of excipient D-sorbite, 30 parts of moisturizer polyethylene glycol, thickener-silica
1.4 parts, 0.8 part of essence leaf of bamboo essence, 1.6 parts of foaming agent sldium lauryl sulfate, 1.2 parts of sweetener Aspartame.
The toothpaste of the present embodiment is made by following preparation method, is concretely comprised the following steps：
（1）Add pure water to decoct twice respectively savatier monochasma herb and peppermint respectively, when each decocting time is 1.7 small, merges and decoct
Liquid, filtering, and it is paste to be concentrated and dried, and respectively obtains Herba monochasmatis extract and mint extract.
（2）According to 3 parts of Herba monochasmatis extract, 2 parts of mint extract, the parts by weight that 80 parts of toothpaste matrix, by step 1 institute
Herba monochasmatis extract and mint extract, and toothpaste matrix is conveyed into de-airing mixer and is stirred and homogeneous, obtains
Lotion；The time of stirring and homogeneous is 30 minutes.
（3）After carrying out sterilization treatment to lotion, the toothpaste for obtaining reference examples 1 is packed with composite soft tube.
Reference examples 2（Not comprising Herba monochasmatis extract component）
A kind of toothpaste, it is composed of the following components in parts by weight：2 parts of Herba Lophatheri extract, 2 parts of mint extract, toothpaste matrix
80 parts；
Wherein, toothpaste matrix is composed of the following components in parts by weight：
30 parts of rubbing agent silica, 15 parts of excipient D-sorbite, 30 parts of moisturizer polyethylene glycol, thickener-silica
1.4 parts, 0.8 part of essence leaf of bamboo essence, 1.6 parts of foaming agent sldium lauryl sulfate, 1.2 parts of sweetener Aspartame.
The toothpaste of the present embodiment is made by following preparation method, is concretely comprised the following steps：
（1）Add pure water to decoct twice respectively lophatherum gracile and peppermint respectively, when each decocting time is 1.5 small, merges and decoct
Liquid, filtering, and it is paste to be concentrated and dried, and respectively obtains Herba Lophatheri extract and mint extract.
（2）According to 2 parts of Herba Lophatheri extract, 2 parts of mint extract, the parts by weight that 80 parts of toothpaste matrix, by step 1 institute
Herba Lophatheri extract and mint extract, and toothpaste matrix is conveyed into de-airing mixer and is stirred and homogeneous, obtains
Lotion；The time of stirring and homogeneous is 26 minutes.
（3）After carrying out sterilization treatment to lotion, the toothpaste for obtaining implementing reference examples 2 is packed with composite soft tube.
Reference examples 3（Not comprising Herba monochasmatis extract component and Herba Lophatheri extract component）
A kind of toothpaste, it is composed of the following components in parts by weight：2 parts of mint extract, 80 parts of toothpaste matrix；
Wherein, toothpaste matrix is composed of the following components in parts by weight：
30 parts of rubbing agent silica, 15 parts of excipient D-sorbite, 30 parts of moisturizer polyethylene glycol, thickener-silica
1.4 parts, 0.8 part of essence leaf of bamboo essence, 1.6 parts of foaming agent sldium lauryl sulfate, 1.2 parts of sweetener Aspartame.
The toothpaste of the present embodiment is made by following preparation method, is concretely comprised the following steps：
（1）Peppermint plus pure water are decocted twice, when each decocting time is 1.5 small, merge decoction liquor, filtering, and concentrate dry
Dry is paste, obtains mint extract.
（2）According to the parts by weight of 80 parts of 2 parts of mint extract and toothpaste matrix, by the mint extract obtained by step 1
De-airing mixer is conveyed into toothpaste matrix to be stirred and homogeneous, obtains lotion；The time of stirring and homogeneous is 26 minutes.
（3）After carrying out sterilization treatment to lotion, the toothpaste for obtaining implementing reference examples 3 is packed with composite soft tube.
The toothpaste of the savatier monochasma herb toothpaste of above-described embodiment 1-3 and reference examples 1-3 are subjected to the test of pesticide effectiveness.
1. toothpaste fungistatic effect is tested
The bacteriostasis of made toothpaste is measured using filter paper enzyme, the strain of selection is：Staphylococcus aureus, H. pylori
Bacterium, Escherichia coli and pseudomonas aeruginosa；Specific test method is as follows：The strain of 37 DEG C of culture 24h is mixed with physiological saline
It is even, mixed liquor bacterial content is reached 105cfu/ml ；0.1ml bacterium solutions are taken to be uniformly coated on beef extract protein solid culture medium,
6 parts of toothpaste liquids that 5ul concentration after dilution is 100mg/ml, and the nothing of a diameter of 6mm of sterile water-soaked are taken respectively
Bacterium filter paper, filter paper is placed on and is applied on bacterium culture medium, is put 37 DEG C of culture 24h, is observed antibacterial circle diameter, preliminary judgement sample
Bacteriostasis, "-" represent that inhibition zone is less than 1mm, represent that toothpaste sample does not have bacteriostasis.Result of the test is shown in Table 1：
The extracorporeal bacteria inhibitor test result of the savatier monochasma herb toothpaste of 1 embodiment 1-3 of table and the toothpaste of reference examples 1-3
As can be seen from Table 1, the savatier monochasma herb ointment compounded using savatier monochasma herb water extract and lophatherum gracile water extract is to golden yellow
Staphylococcus, helicobacter pylori, the fungistatic effect of Escherichia coli and pseudomonas aeruginosa are good, especially to causing canker sore
Staphylococcus aureus and helicobacter pylori suppress and killing effect it is notable；And individually use savatier monochasma herb water extract or light
The toothpaste of leaf of bamboo water extract, or do not add savatier monochasma herb water extract and lophatherum gracile water extract toothpaste it is thin to above-mentioned 4 kinds
The inhibition of bacterium is poor.This is demonstrated in the savatier monochasma herb toothpaste in embodiment 1-3, since both savatier monochasma herb and lophatherum gracile cooperate with
Synergy, especially savatier monochasma herb benzyl carbinol glycosides and lophatherum gracile active polysaccharide cooperate, and play good antibacterial and killing effect, right
The inhibitory action of pathogenic bacteria is with strong points, so as to promote the healing of the oral inflammation surface of a wound.
2. the effect of toothpaste anti-treating dental ulcer, is evaluated
Selection 300 suffers from canker sore and the diseased date is identical, the suitable volunteer of extent, wherein 182 people of male, female
118 people of property are divided into 6 groups, every group of 50 people, respectively using the savatier monochasma herb toothpaste of embodiment 1-3 and the toothpaste of reference examples 1-3, daily
Once in the morning and once at night, carry out within 7 days by a definite date being applicable in experiment.
Evaluation criterion is as follows：
Cure：Ulcer disappears, and wound healing rate is higher than 90%；
It is effective：Pain disappears, and wound healing rate is 75%-90%；
Effectively：Pain relief, wound healing rate are 50%-75%；
It is invalid：Constant pain, wound healing rate are less than 50%.
The results are shown in Table 2 for therapeutic evaluation：
The patient of the savatier monochasma herb toothpaste of 2 embodiment 1-3 of table and the toothpaste of reference examples 1-3 is applicable in result of the test
| Treat group | Cure | It is effective | Effectively | It is invalid | It is efficient（%） | Cure rate（%） |
| Embodiment 1 | 41 | 3 | 4 | 2 | 96 | 82 |
| Embodiment 2 | 40 | 3 | 4 | 3 | 94 | 80 |
| Embodiment 3 | 38 | 6 | 3 | 3 | 94 | 76 |
| Reference examples 1 | 3 | 6 | 20 | 21 | 58 | 6 |
| Reference examples 2 | 4 | 4 | 21 | 21 | 58 | 8 |
| Reference examples 3 | 2 | 3 | 16 | 29 | 42 | 4 |
From table 2 it can be seen that using the patient of the embodiment 1-3 savatier monochasma herb toothpaste being prepared, its it is efficient 90% with
On, especially the savatier monochasma herb toothpaste of embodiment 1 and embodiment 2, cure rate respectively reach 82% and 80%, treat the effect of canker sore
Fruit is notable.And individually using savatier monochasma herb water extract or the toothpaste of lophatherum gracile water extract, or the extraction of savatier monochasma herb water is not added
The toothpaste of thing and lophatherum gracile water extract, the effect for treating canker sore are not then clearly.
It can be seen from the above that above-described embodiment 1-3 provide savatier monochasma herb toothpaste, by savatier monochasma herb, lophatherum gracile and peppermint this three
The water extract of kind Chinese medicine carries out reasonable compatibility, its active ingredient and mechanism of action are all relatively clearer and more definite, which has well
Inhibiting bacteria and diminishing inflammation and analgesic efficacy, since the suppression to pathogenic bacteria is with strong points, and have the resident bacteria of non-pathogenic less
Inhibitory action, so as to effectively improve self-healing ability and oral restoration ability of the oral cavity tissue to damage.The deer that embodiment 1-3 is provided
Fine and soft grass toothpaste can promote the healing of the oral inflammation surface of a wound, therefore also have to oral cavity life sore and swelling and aching of gum etc. oral inflammation good
Therapeutic effect, its scientific formulation is simple, cost of material is low, cost-effective.
The structure example and explanation of the above content only present invention, its description is more specific and detailed, but simultaneously
Therefore the limitation to the scope of the claims of the present invention cannot be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these obviously replace shape
Formula belongs to protection scope of the present invention.
Claims (5)
1. a kind of savatier monochasma herb toothpaste, it is characterised in that composed of the following components in parts by weight：3-6 parts of Herba monochasmatis extract is light
2-4 parts of bamboo extractive, 2-4 parts of mint extract, 73-86 parts of toothpaste matrix.
2. savatier monochasma herb toothpaste according to claim 1, it is characterised in that the toothpaste matrix is in parts by weight by with the following group
It is grouped into：27-32 parts of rubbing agent, 14-17 parts of excipient, 28-31 parts of moisturizer, 1.2-1.6 parts of thickener, essence 0.5-1.1
Part, 1.3-1.8 parts of foaming agent, 1.0-1.5 parts of sweetener.
3. savatier monochasma herb toothpaste according to claim 1, it is characterised in that composed of the following components in parts by weight：Pilose antler
Careless 3 parts of extract, 2 parts of Herba Lophatheri extract, 2 parts of mint extract, 80 parts of toothpaste matrix；
The toothpaste matrix is composed of the following components in parts by weight：
30 parts of rubbing agent, 15 parts of excipient, 30 parts of moisturizer, 1.4 parts of thickener, 0.8 part of essence, 1.6 parts of foaming agent, sweetener
1.2 part.
4. according to any savatier monochasma herb toothpaste of Claims 2 or 3, it is characterised in that in the toothpaste matrix,
The rubbing agent is one or any several in silica, calcium carbonate, calcium bicarbonate and calcium phosphate dibasic dihydrate
Mixture；
The excipient is D-sorbite；
The moisturizer is one or any several mixture in glycerine, propane diols, polyethylene glycol and sorbierite；
The thickener is silica；
The essence is any one in Mint Essence, leaf of bamboo essence, spearmint essence and strawberry essence；
The foaming agent sldium lauryl sulfate；
The sweetener is saccharin sodium or Aspartame.
5. the preparation method of a kind of savatier monochasma herb toothpaste as described in claim 1-3 is any, it is characterised in that specific steps are such as
Under：
（1）Add pure water to decoct twice respectively savatier monochasma herb, lophatherum gracile and peppermint respectively, when each decocting time is 1.5 small, close
And decoction liquor, filtering, and it is paste to be concentrated and dried, and respectively obtains Herba monochasmatis extract, Herba Lophatheri extract and peppermint extraction
Thing；
（2）Composition weight number described in accordance with the claim 1, by the Herba monochasmatis extract obtained by step 1, Herba Lophatheri extract
And mint extract, and toothpaste matrix is conveyed into de-airing mixer and is stirred and homogeneous, obtains lotion；It is described stirring and
The time of matter is 20-30 minutes；
（3）After carrying out sterilization treatment to lotion, packed with composite soft tube and obtain savatier monochasma herb toothpaste.
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| CN110787104A (en) * | 2018-08-20 | 2020-02-14 | 惠州市九惠制药股份有限公司 | Compound traditional Chinese medicine toothpaste and preparation method and application thereof |
| CN114983885A (en) * | 2022-05-17 | 2022-09-02 | 广州医家仁生物科技有限责任公司 | Rose toothpaste and preparation method thereof |
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