CN106309325A

CN106309325A - Antibacterial and anti-inflammatory mouthwash and preparation method thereof

Info

Publication number: CN106309325A
Application number: CN201610864174.1A
Authority: CN
Inventors: 袁国防; 张丽丽; 赵雪; 邢晓燕
Original assignee: Qingdao Haizhiyuan Intelligent Technology Co Ltd
Current assignee: Qingdao Haizhiyuan Intelligent Technology Co Ltd
Priority date: 2016-09-29
Filing date: 2016-09-29
Publication date: 2017-01-11

Abstract

The invention discloses antibacterial and anti-inflammatory mouthwash and a preparation method thereof. A main effective component of the mouthwash is a traditional Chinese medicinal extract. The Chinese medicinal extract is prepared from the following raw materials in parts by weight: 25 to 30 parts of rose flower, 4 to 8 parts of flower and root of rosa multiflora, 15 to 20 parts of honeysuckle flower, 6 to 12 parts of herba houttuyniae, 8 to 13 parts of fructus forsythia, 3 to 6 parts of all grass of tagetes patula L, 2 to 4 parts of fructus toosendan, 6 to 8 parts of cortex magnoliae officinalis, 10 to 15 parts of Chinese gall, 4 to 6 parts of roughhaired holly root, 6 to 8 parts of rhizoma polygoni cuspidati, 8 to 12 parts of radix bupleuri, 28 to 35 parts of fresh green lemon, 7 to 10 parts of radix paeoniae alba, 8 to 12 parts of eucalyptus globules and 6 to 9 parts of prepared liquorice root. The mouthwash can realize antibacterial and anti-inflammatory effects while teeth are cleaned in a mouth rinsing process; the mouthwash has the efficacy of effectively inhibiting pathogenic bacteria in an oral cavity from breeding, preventing and treating diseases such as pericoronitis of the wisdom tooth, and preventing serious systemic complications caused by oral diseases such as bacteremia and septicemia.

Description

A kind of anti-inflammation collutory and preparation method thereof

Technical field

The present invention relates to oral cleaning nursing article technical field, especially a kind of anti-inflammation collutory.

Background technology

Collutory is indispensable oral cavity cleaning hygienic article in people's daily life, and its basic function is to clean tooth Tooth, fresh breath, reach to keep the purpose of oral cavity cleaning.In recent years, owing to consumer healthcare realizes constantly enhancing, to collutory Propose more requirement, also add some auxiliary prevention oral diseases except cleaning the teeth, oral cavity is had nursing health effect Function, development functionality collutory becomes the market mainstream of present stage.Pericoronitis of the wisdom tooth refers to that wisdom tooth (third molar) eruption is the most complete Or during impaction, the inflammation that corona surrounding soft tissue occurs.Mostly occur in 18～the youngster of 30 years old wisdom tooth eruption period, be oral cavity One of commonly encountered diseases of decorative sursery outpatient service.The clinical manifestation of pericoronitis of the wisdom tooth acute stage is mainly that wisdom teeth position is uncomfortable, pain Deng, develop further, show as difficulty in opening mouth, halitosis, sting thing, swallow thing difficulty etc., more seriously arise that complete Body symptom, as heating, leukocyte rise high, chronic phase, mainly shows as uncomfortable, the swelling in wisdom teeth position etc., it is also possible to bacterium occur The complication such as mass formed by blood stasis, septicemia, pulpitis, periapical periodontitis.The treatment of pericoronitis of the wisdom tooth is attached most importance to Local treatment, local the most again with In removing gingival pocket, food debris, slough, pus are main.Conventional normal saline, 1%～3% hydrogenperoxide steam generator.1:5000 Potassium permanganate liquid, 0.1% chlorhexidine liquid etc. rinse gingival pocket repeatedly, to spillage limpid.But these cleanout fluid cleanout fluid Antibacterial and anti-inflammation functions barely satisfactory.And mostly there is zest be not suitable for using as daily nursing for a long time.

Summary of the invention

Present invention aim at providing a kind of anti-inflammation collutory and preparation method thereof, this collutory can be by gargling Process while cleaning tooth, play and can grow by pathogenic bacterium in antibacterial and anti-inflammation functions, effectively suppression oral cavity, prophylactic treatment intelligence The diseases such as tooth pericoronitis, the systemic complications as serious in bacteremia, septicemia etc. that prevention is caused by oral disease.

To achieve these goals, the technical scheme that the present invention provides is as follows:

A kind of anti-inflammation collutory, raw material and the mass percent thereof of making described collutory be: Chinese medicine extract 45- 60%, food-grade ethanol 9-12%, Tween 80 2.0-2.4%, sorbic acid 15-18%, essence 0.7-0.9%, surplus for go from Sub-water；Raw material and the parts by weight thereof of making described Chinese medicine extract are: Flos Rosae Rugosae 25-30 part, white residual flower 4-8 part, Flos Lonicerae 15-20 part, Herba Houttuyniae 6-12 part, Fructus Forsythiae 8-13 part, Herba Tagetis Patulae 3-6 part, Fructus Toosendan 2-4 part, Cortex Magnoliae Officinalis 6-8 part, Galla Chinensis 10-15 Part, Radix Ilicis Asprellae 4-6 part, Rhizoma Polygoni Cuspidati 6-8 part, Radix Bupleuri 8-12 part, green lemon fresh goods 28-35 part, Radix Paeoniae Alba 7-10 part, Eucalyptus globulus Labill 8-12 part, Radix Glycyrrhizae Preparata 6-9 part.

Preferably, raw material and the parts by weight thereof of making described Chinese medicine extract are: Flos Rosae Rugosae 25 parts, white residual flower 4 parts, gold Flos Lonicerae 15 parts, Herba Houttuyniae 6 parts, Fructus Forsythiae 8 parts, Herba Tagetis Patulae 3 parts, Fructus Toosendan 2 parts, Cortex Magnoliae Officinalis 6 parts, Galla Chinensis 10 parts, Radix Ilicis Asprellae 4 parts, Rhizoma Polygoni Cuspidati 6 parts, Radix Bupleuri 8 parts, green lemon fresh goods 28 parts, the Radix Paeoniae Alba 7 parts, Eucalyptus globulus Labill 8 parts, Radix Glycyrrhizae Preparata 6 parts.

Preferably, raw material and the parts by weight thereof of making described Chinese medicine extract are: Flos Rosae Rugosae 30 parts, white residual flower 8 parts, gold Flos Lonicerae 20 parts, Herba Houttuyniae 12 parts, Fructus Forsythiae 13 parts, Herba Tagetis Patulae 6 parts, Fructus Toosendan 4 parts, Cortex Magnoliae Officinalis 8 parts, Galla Chinensis 15 parts, Radix Ilicis Asprellae 6 Part, Rhizoma Polygoni Cuspidati 8 parts, Radix Bupleuri 12 parts, green lemon fresh goods 35 parts, the Radix Paeoniae Alba 10 parts, Eucalyptus globulus Labill 12 parts, Radix Glycyrrhizae Preparata 9 parts.

Preferably, raw material and the parts by weight thereof of making described Chinese medicine extract are: Flos Rosae Rugosae 27 parts, white residual flower 6 parts, gold Flos Lonicerae 18 parts, Herba Houttuyniae 9 parts, Fructus Forsythiae 11 parts, Herba Tagetis Patulae 5 parts, Fructus Toosendan 3 parts, Cortex Magnoliae Officinalis 7 parts, Galla Chinensis 12 parts, Radix Ilicis Asprellae 5 parts, Rhizoma Polygoni Cuspidati 7 parts, Radix Bupleuri 10 parts, green lemon fresh goods 31 parts, the Radix Paeoniae Alba 8 parts, Eucalyptus globulus Labill 10 parts, Radix Glycyrrhizae Preparata 7 parts.

Preferably, raw material and the mass percent thereof of making described collutory be: Chinese medicine extract 50%, food-grade ethanol 10%, Tween 80 2.2%, sorbic acid 16%, essence 0.8%, deionized water 21%.

The invention also discloses the preparation method of described a kind of anti-inflammation collutory, comprise the following steps:

(1) Flos Rosae Rugosae, white residual flower, Flos Lonicerae, Herba Houttuyniae, Fructus Forsythiae, Herba Tagetis Patulae, Fructus Toosendan, Cortex Magnoliae Officinalis, Galla Chinensis, Radix Ilicis Asprellae, Rhizoma Polygoni Cuspidati, Radix Bupleuri, the Radix Paeoniae Alba, Eucalyptus globulus Labill, Radix Glycyrrhizae Preparata co-grinding obtain 50 mesh mixed-powders, and gained mixed-powder adds gross mass multiple 4 Water soaking again 1 hour, slow fire boiling 1 hour, cross 100 mesh drainage screen separation filtering residues, filtrate after decoction, gained filtrate is cooled to Room temperature is standby；

(2) green lemon cleans rear cutout fritter, adds and crosses 100 mesh mistakes after standing 0.5 hour after step (1) gained filtrate is squeezed the juice Filter screen separation filtering residue, filtrate；

(3) mixing filtering residue gross mass multiple 4 times is added with step (2) gained filtering residue after step (1) gained filtering residue mixes Water soaking 0.5 hour, crosses 100 mesh drainage screens and obtains filtrate after slow fire boiling 1 hour, it is standby that gained filtrate is cooled to room temperature；

(4) step (2) gained filtrate and step (3) gained filtrate mixing and stirring i.e. obtain Chinese medicine extract, in gained Medicament extract adds food-grade ethanol, Tween 80, sorbic acid, essence and ionized water mixing and stirring and i.e. obtains anti-inflammation and gargle Water.

Using method: routine use uses this mouthwash can play cleaning oral cavity three after the meal, prophylactic Effect；Pericoronitis of the wisdom tooth patient carries out local by this product and treats, and needs repeatedly to rinse by this product gingival pocket, limpid to spillage is Only.

Food debris remains on tooth after the meal, meeting breed bacteria in oral cavity, causes the disease such as periodontitis, pericoronitis, The especially existence of wisdom teeth, it is easier to food residual, diseases induced, use mouthwash after the meal, cleaning food can be played Residue effect, but major part collutory is in order to play antibacterial action the most on the market, contains fluorine, antibiotic, Borax, chlorine etc. more Material, frequently uses and easily causes side effect, and the collutory of the present invention is using Chinese medicine extract as principle active component, it is achieved antibacterial The effect of antiinflammatory, by the process gargled while cleaning tooth, playing can cause in antibacterial and anti-inflammation functions, effectively suppression oral cavity The diseases such as pathogenic bacteria grows, prophylactic treatment pericoronitis of the wisdom tooth, prevent by oral disease cause as serious in bacteremia, septicemia etc. Systemic complications.Combining Traditional Chinese doctors ' theory, preferably natural material preparation in preparation process, formula safety non-toxic is secondary Effect, compatibility is proper, in selected raw material:

Flos Rosae Rugosae: hardship sweet, micro-, temperature, promoting QI circulation for relieving depression, and blood, pain relieving, this product abnormal smells from the patient delicate fragrance, kind can depressed liver-energy dispersing and QI regulating and resolving depression, It is primarily adapted for use in depression of liver-QI, uncomfortable in chest and incoordination between the liver and stomach, abdominal distention, belch the disease such as then to relax；

White residual flower: bitter, puckery, cold, clearing away summer-heat heat, removing dampness is turbid, pleasant stomach function regulating.Cure mainly summer-heat uncomfortable in chest, thirsty, vomiting, do not think drink Food, aphtha erosion of the oral mucosa；

Flos Lonicerae: cold in nature, sweet in the mouth, enter lung, the heart, stomach warp, there is heat-clearing and toxic substances removing, antiinflammatory, effect of qi-restoratives treatment wind, cure mainly swollen Completely descending disease, epidemic febrile disease to generate heat, the disease such as pyretic toxicity carbuncle and ulcer and tumor, it makees thirsty, hyperhidrosis unhappiness, enteritis, bacterium for dizzy dizzy, xerostomia Dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, the parotid gland The diseases such as inflammation, suppurative tonsillitis all have certain curative effect, experiment in vitro to show, this product is to various pathogens such as golden yellow Fructus Vitis viniferae Coccus, Hemolytic streptococcus, escherichia coli, dysentery bacterium, vibrio cholera, Bacillus typhi, Salmonella paratyphi etc. all have and necessarily press down Make use, the most effective to streptococcus pneumoniae, meningococcus, bacillus pyocyaneus, tubercule bacillus；

Herba Houttuyniae: cold nature, bitter in the mouth, heat-clearing and toxic substances removing, removing pus and relieving carbuncle, inducing diuresis for treating stranguria syndrome, control pneumonia, lung abscess, hematodiarrhoea, malaria Disease, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies, Herba Houttuyniae can strengthen the phagocytic activity of WBC, Improving serum properdin, Herba Houttuyniae improves immunity of organisms, and the treatment to venereal infection has great significance, and carries in Herba Houttuyniae Obtain a kind of yellow oil, various microorganisms (especially yeast and mycete) are all had inhibitory action, the hammer to hemolytic Bacterium, staphylococcus aureus, hemophilus influenza, micrococcus catarrhalis, streptococcus pneumoniae have obvious inhibitory action；

Fructus Forsythiae: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens, modern medicine study confirms, Fructus Forsythiae concentrated decotion has in vitro Antibacterial action, can suppress Bacillus typhi, Salmonella paratyphi, escherichia coli, dysentery bacterium, diphtheria corynebacterium and vibrio cholera, Fructus Vitis viniferae Coccus, streptococcus etc.；

Herba Tagetis Patulae: bitter, flat, clearing away heat-damp and promoting diuresis, cough-relieving, pain relieving, for upper respiratory tract infection, dysentery, cough, pertussis, tooth Bitterly, acute conjunctivitis due to pathogenic windfire, parotitis, mastitis are controlled in external；

Fructus Toosendan: bitter, cold, soothing liver-QI promoting the circulation of QI to relieve pain, anthelmintic, for the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation；

Cortex Magnoliae Officinalis: toil, temperature, warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, dampness, expectorant, control chest and abdomen feeling of fullness distending pain, regurgitation, vomiting, dyspepsia does not disappears, expectorant Drink is breathed with cough, cold-damp dysentery, and its aqueous solution has certain bacteriostasis to staphylococcus aureus, sarcina and bacillus subtilis. Cortex Magnoliae Officinalis also has antibacterial activity to Diplococcus pneumoniae and dysentery bacterium,

Galla Chinensis: cold in nature, sour in the mouth, puckery, there is the effects such as pathogenic fire reducing of astringing the lung, relieving diarrhea with astringents, arresting sweating hemostasis, removing dampness sore, main Controlling the diseases such as chronic cough of deficiency lung, chronic diarrhea chronic dysentery, hemorrhoidal bleeding of having blood in stool, carbuncle sore tumefacting virus, Skin wet and rotten, Galla Chinensis decoct is to Staphylococcus aureus Bacterium, beta hemolytic streptococcus, streptococcus pneumoniae, bacillus pyocyaneus, dysentery bacterium, anthrax bacillus, diphtheria corynebacterium, escherichia coli, wound Cold and Salmonella paratyphi etc. all has the most antibacterial and bactericidal action；

Radix Ilicis Asprellae: bitter, sweet is cool.There is heat-clearing and toxic substances removing, promoting the production of body fluid to quench thirst, effect of dissipating blood stasis, be usually used in flu, have a headache, dizzy Dizzy, calentura excessive thirst, eruptive disease, diarrhea of heat type, lung abscess, pertussis, laryngopharynx swelling and pain, hemorrhoidal bleeding, gonorrhea, furuncle swelling toxin, traumatic injury；

Rhizoma Polygoni Cuspidati: mildly bitter flavor, cold nature, there is dampness removing jaundice eliminating, heat-clearing and toxic substances removing, eliminating stasis to stop pain, effect of relieving cough and resolving phlegm, be used for Jaundice due to damp-heat, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, carbuncle sore tumefacting virus, burn due to hot liquid or fire, amenorrhea, lump in the abdomen, instep beats damage, cough due to lung-heat, tiger Cane decocting liquid has inhibitory action to staphylococcus aureus, micrococcus catarrhalis, A type or group B streptococcus, escherichia coli, bacillus pyocyaneus；

Radix Bupleuri: nature and flavor are bitter, be slightly cold, returns liver, gallbladder meridian, has a reconciling superficies and interior, effect of soothing the liver yang invigorating, for cold, fever, cold Heat contact, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterine prolapse, menoxenia, Radix Bupleuri aqueous extract is to golden yellow Fructus Vitis viniferae Coccus, Bacillus typhi etc. significantly inhibit effect；

Green lemon: Fructus Citri Limoniae is one of fruit having medical value most, it rich in vitamin C, saccharide, calcium, phosphorus, Ferrum, vitamin B1, vitamin B2, nicotinic acid quininic acid, citric acid, malic acid, Hesperidin, naringin, coumarin, a large amount potassium element With low amounts sodium element etc., Fructus Citri Limoniae has removing heat-phlegm effect, and Fructus Citri Limoniae is rich in vitamin C, and the effect playing human body is just as natural Antibiotic, has anti-inflammation, strengthens the multiple efficacies such as body immunity, and Fructus Citri Limoniae, rich in vitamin C and Citrin, can strengthen Blood vessel elasticity and toughness, can prevent and treat hypertension and myocardial infarction symptoms；

The Radix Paeoniae Alba: cool in nature, bitter in the mouth acid, it is slightly cold, there is the effects such as blood-supplementing blood-nourishing, suppressing liver-YANG, easing the affected liver to relieve pain, astringing YIN to stop sweating, Being applicable to fever due to yin deficiency, menoxenia, the chest and abdomen pain over the hypochondriac region, extremity contraction anxious, dysentery stomachache, spontaneous sweating, metrorrhagia, band are inferior Disease, Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus Deng；

Eucalyptus globulus Labill: the micro-hardship pungent, micro-of taste, property is put down.Dispelling wind is antipyretic, inhibiting bacteria and diminishing inflammation, and anticorrosion is antipruritic.For prevent influenza, Epidemic cerebrospinal meningitis, controls upper respiratory tract infection, pharyngolaryngitis, bronchitis, pneumonia, Acute and chronic pyelonephritis, enteritis, dysentery Disease, filaricide；Burn and scald, cellulitis, mastitis, furuncle and phyma, erysipelas, paddy-field dermatitis, skin eczema, tinea pedis, skin are controlled in external Sterilization；

Radix Glycyrrhizae Preparata: containing multiple chemical compositions such as glycyrrhizin, enoxolone, Angelica Polysaccharide, there is antiinflammatory and resistance state Reagentia, scalable body's immunity, antitumor and analgesic effect, therefore the primary efficacy of Radix Glycyrrhizae Preparata is and middle emergency, Lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.

The traditional Chinese medical science thinks that the Etiological of pericoronitis is to attack outside wind heat, gastrointestinal intrinsic heat, and liver and gall fire is contained caused, and the present invention gargles The effective ingredient of the Chinese medicine extract contained by water, uses antibacterial bacteriostatic, heat-clearing and toxic substances removing, the method for soothing the liver pathogenic fire purging, effectively prevents and treats mouth Chamber disease, especially pericoronitis of the wisdom tooth.In the raw material of the Chinese medicine extract making principle active component, Flos Lonicerae, Herba Houttuyniae, company Stick up, Cortex Magnoliae Officinalis, Galla Chinensis, Rhizoma Polygoni Cuspidati, Radix Bupleuri, green lemon, the Radix Paeoniae Alba, Eucalyptus globulus Labill share has good bactericidal and bacteriostatic effect, can be in cleaning Effectively kill pathogenic bacterium while remaining in the food debris on wisdom teeth, prevent and treat all kinds of oral cavity infection；White residual flower, Flos Lonicerae, fish raw meat Grass, Fructus Forsythiae, Fructus Toosendan, Radix Ilicis Asprellae, Rhizoma Polygoni Cuspidati, green lemon, Eucalyptus globulus Labill share the effect also with heat-clearing and toxic substances removing, Flos Rosae Rugosae, Fructus Toosendan, thickness Piao, Galla Chinensis, Radix Bupleuri, the Radix Paeoniae Alba share the effect that can be total to long memorial liver pathogenic fire purging, and the effective ingredient of collutory acts in oral cavity, in cleaning Oral cavity, while anti-inflammation, it is also possible to removes oral cavity endogenous wind pathogenic heat poison, regulates internal environment of oral cavity, effectively prevents and treats multiple oral cavity Disease, for pericoronitis of the wisdom tooth, can use these collutory product to carry out local in acute stage and treat, repeatedly rinse gum by this product Bag, to spillage limpid, compared to conventional cleanout fluid such as hydrogenperoxide steam generators, this mouthwash formula is gentle, and has more Good anti-inflammation and therapeutic effect；Raw material Radix Glycyrrhizae can make the property of medicine more gentle with coordinating the actions of various ingredients in a prescription, promotes drug effect, and each raw material has The effect comprehensive synergism of composition, compatibility is proper, while safely and effectively cleaning oral cavity, can effectively prevent and treat pericoronitis of the wisdom tooth etc. many Plant disease.In addition, raw material Fructus Citri Limoniae also rich in Citrin can strengthen blood vessel wall intensity, protect intraoral blood capillary Pipe, recovers blood capillary elastic, effectively prevents from being caused affected part Permeability of Capillary Wall to increase by inflammation, causes substantial amounts of causing a disease Bacterium enters blood through capillary wall, thus prevents pathogenic bacterium from breeding the systemic diseases such as initiation bacteremia in blood, with Time cut off the pathogenic bacterium path with blood born, effectively prevention reduces the complication of other histoorgans and produces.Raw material Flos Rosae Rugosae Flower and green lemon have aromatic odor, can cover the taste of part Chinese medicine so that this collutory taste is more easy to entrance, convenient long-term Use.This collutory uses Chinese medicine extract as effectively becoming, it is achieved the effect of anti-inflammation, it is to avoid containing fluorine, antibiosis The use of the materials such as element, Borax, chlorine, formula more safety is gentle, decreases the side effect of life-time service, can be used for periodontal oral cavity The daily protection of disease.

Beneficial effects of the present invention: providing a kind of anti-inflammation collutory and preparation method thereof, this collutory can lead to Cross the process gargled while cleaning tooth, play and can grow by pathogenic bacterium in antibacterial and anti-inflammation functions, effectively suppression oral cavity, prevention The diseases such as treatment pericoronitis of the wisdom tooth, the systemic complications as serious in bacteremia, septicemia etc. that prevention is caused by oral disease. Specifically:

(1) effective ingredient of the Chinese medicine extract contained by the collutory of the present invention, uses antibacterial bacteriostatic, heat-clearing and toxic substances removing, dredges The method of liver pathogenic fire purging, effectively prevents and treats oral disease, especially pericoronitis of the wisdom tooth.Make the Chinese medicine extract of principle active component In raw material, Flos Lonicerae, Herba Houttuyniae, Fructus Forsythiae, Cortex Magnoliae Officinalis, Galla Chinensis, Rhizoma Polygoni Cuspidati, Radix Bupleuri, green lemon, the Radix Paeoniae Alba, Eucalyptus globulus Labill share has very well Bactericidal and bacteriostatic effect, can cleaning remain in the food debris on wisdom teeth while effectively kill pathogenic bacterium, prevent and treat all kinds of oral cavity Infect；White residual flower, Flos Lonicerae, Herba Houttuyniae, Fructus Forsythiae, Fructus Toosendan, Radix Ilicis Asprellae, Rhizoma Polygoni Cuspidati, green lemon, Eucalyptus globulus Labill share also has heat clearing away solution The effect of poison, Flos Rosae Rugosae, Fructus Toosendan, Cortex Magnoliae Officinalis, Galla Chinensis, Radix Bupleuri, the Radix Paeoniae Alba share the effect that can be total to long memorial liver pathogenic fire purging, collutory effective Composition acts in oral cavity, in cleaning oral cavity, while anti-inflammation, it is also possible to removes oral cavity endogenous wind pathogenic heat poison, regulates oral cavity Interior environment, effectively prevents and treats multiple oral disease, for pericoronitis of the wisdom tooth, these collutory product can be used to carry out local in acute stage Treatment, repeatedly rinse gingival pocket by this product, to spillage limpid, compared to conventional cleanout fluid such as hydrogenperoxide steam generators, this is gargled Saliva formula is gentle, and has more preferable anti-inflammation and therapeutic effect；Raw material Radix Glycyrrhizae can make the property of medicine more flat with coordinating the actions of various ingredients in a prescription With, promoting drug effect, the comprehensive synergism of each material effective component, compatibility is proper, while safely and effectively cleaning oral cavity, can have The multiple diseases such as effect preventing and treating pericoronitis of the wisdom tooth.

(2) raw material Fructus Citri Limoniae also rich in Citrin can strengthen blood vessel wall intensity, protect intraoral blood capillary, extensive Multiple blood capillary is elastic, effectively prevents from being caused affected part Permeability of Capillary Wall to increase by inflammation, causes substantial amounts of pathogenic bacterium to be worn Cross capillary wall and enter blood, thus prevent pathogenic bacterium from breeding the systemic diseases such as initiation bacteremia in blood, cut simultaneously Broken the pathogenic bacterium path with blood born, and effectively prevention reduces the complication generation of other histoorgans.

(3) raw material Flos Rosae Rugosae and green lemon have natural fragrance abnormal smells from the patient, can cover the taste of part Chinese medicine so that this is gargled Water taste road is more easy to entrance, facilitates life-time service.This collutory uses Chinese medicine extract as effectively becoming, it is achieved anti-inflammation Effect, it is to avoid use containing materials such as fluorine, antibiotic, Borax, chlorine, formula more safety is gentle, decreases life-time service Side effect, can be used for the daily protection of periodontal oral disease.

Detailed description of the invention

According to following embodiment, the present invention be may be better understood.But, as it will be easily appreciated by one skilled in the art that reality Execute concrete material proportion, process conditions and result thereof described by example be merely to illustrate the present invention and not should also without limitation on The present invention described in detail in claims.

Embodiment 1

A kind of anti-inflammation collutory, raw material and the mass percent thereof of making described collutory be: Chinese medicine extract 45%, food-grade ethanol 9%, Tween 80 2.0%, sorbic acid 15%, essence 0.7%, ionized water 28.3%；Make described in The raw material of medicament extract and parts by weight thereof are: Flos Rosae Rugosae 25 parts, white residual flower 4 parts, Flos Lonicerae 15 parts, Herba Houttuyniae 6 parts, Fructus Forsythiae 8 Part, Herba Tagetis Patulae 3 parts, Fructus Toosendan 2 parts, Cortex Magnoliae Officinalis 6 parts, Galla Chinensis 10 parts, Radix Ilicis Asprellae 4 parts, Rhizoma Polygoni Cuspidati 6 parts, Radix Bupleuri 8 parts, green lemon is fresh Product 28 parts, the Radix Paeoniae Alba 7 parts, Eucalyptus globulus Labill 8 parts, Radix Glycyrrhizae Preparata 6 parts.

The preparation method of described collutory, comprises the following steps:

Embodiment 2

A kind of anti-inflammation collutory, raw material and the mass percent thereof of making described collutory be: Chinese medicine extract 60%, food-grade ethanol 12%, Tween 80 2.4%, sorbic acid 18%, essence 0.9%, ionized water 6.7%；Make described in The raw material of medicament extract and parts by weight thereof are: Flos Rosae Rugosae 30 parts, white residual flower 8 parts, Flos Lonicerae 20 parts, Herba Houttuyniae 12 parts, Fructus Forsythiae 13 parts, Herba Tagetis Patulae 6 parts, Fructus Toosendan 4 parts, Cortex Magnoliae Officinalis 8 parts, Galla Chinensis 15 parts, Radix Ilicis Asprellae 6 parts, Rhizoma Polygoni Cuspidati 8 parts, Radix Bupleuri 12 parts, green lemon Fresh goods 35 parts, the Radix Paeoniae Alba 10 parts, Eucalyptus globulus Labill 12 parts, Radix Glycyrrhizae Preparata 9 parts.

Preparation method and the using method of the collutory of embodiment 2 are same as in Example 1.

Embodiment 3

A kind of anti-inflammation collutory, it is characterised in that raw material and the mass percent thereof of making described collutory be: in Medicament extract 50%, food-grade ethanol 10%, Tween 80 2.2%, sorbic acid 16%, essence 0.8%, deionized water 21%；System The raw material and the parts by weight thereof that become described Chinese medicine extract are: Flos Rosae Rugosae 27 parts, white residual flower 6 parts, Flos Lonicerae 18 parts, Herba Houttuyniae 9 Part, Fructus Forsythiae 11 parts, Herba Tagetis Patulae 5 parts, Fructus Toosendan 3 parts, Cortex Magnoliae Officinalis 7 parts, Galla Chinensis 12 parts, Radix Ilicis Asprellae 5 parts, Rhizoma Polygoni Cuspidati 7 parts, Radix Bupleuri 10 Part, green lemon fresh goods 31 parts, the Radix Paeoniae Alba 8 parts, Eucalyptus globulus Labill 10 parts, Radix Glycyrrhizae Preparata 7 parts.

Preparation method and the using method of the collutory of embodiment 3 are same as in Example 1.

Embodiment 4 antiinflammatory pharmacological experiment

Xylol is used to cause the antiinflammatory action experimental technique of Mice Auricle acute inflammation swelling.Take healthy male Kunming kind White mice 30, body weight 18～22g, the most equal 3 groups, often group 10.Blank group (normal saline 0.1ml/ is only), it is right to treat According to group (fluocinonide cream 0.1g/ is only), collutory sample sets (is prepared by embodiment 3,0.1ml/ is only).Respectively organize every during experiment Inside and outside animal auris dextra exterior feature, two sides uniform application dimethylbenzene 0.1ml/ is only, causes inflammation, and left ear is untreated makees self-blank comparison.It is coated with After smearing dimethylbenzene 30min, two sides uniform application group tested material sample respectively inside and outside every animal auris dextra exterior feature of each group.It is administered 1h After, mice cervical dislocation is put to death, and cuts two auricles, washes away auris dextra exterior feature tested material sample with normal saline, and dry cotton ball is cleaned, overlapping Two auricles, take two circle auricles with the card punch of internal diameter 8mm at same position chisel, claim respectively on FA1004 type electronic analytical balance Weight, it is swelling value that auris dextra sheet weight deducts left auricle weight, and data carry out statistics t inspection, and result is as shown in the table.

Group	Dosage	Auricle edema value (mg)
			Blank group	0.1ml/ is only	17.01±2.56
Treatment matched group	0.1g/ is only	11.23±1.89**
			Collutory sample controls group	0.1ml/ is only	11.89±2.13**

Compare with blank group: * P ＜ 0.05, * * P ＜ 0.01.

Test result indicate that, the collutory sample of the present invention and fluocinonide cream group all can make chmice acute inflammation swell Swollen auricle weight significantly alleviates, hence it is evident that suppression dimethylbenzene induced mice auricle acute inflammation swelling, shows that this collutory is to acute Inflammation has obvious antiinflammatory action.

Embodiment 5 allergic experiment

Take healthy albino guinea-pig 18, body weight 250-300g, male and female dual-purpose, before test, reject both sides dorsal body setae, every side 3 × 3cm, is randomly divided into test group, blank group and positive controls, blank group not medication, positive controls with 2,4-bis- Chloronitrobenzene, sensitization 1% concentration, excite and use 0.1% concentration；The test group collutory of the embodiment of the present invention 3.Take the present invention The collutory of embodiment 3 is applied to back and goes to hair-fields, the next day 1 time, totally 3 times.Contact latter 14 days in last, be coated with at back the same area Collutory, removes after medicine after 6h and at once observes, and in 24,48,72h observes with or without anaphylaxis.Blank group and the positive Matched group excites contact by same method and observes.Result of the test: positive controls animal skin i.e. occurs limitation after sensitization 1 hour Property erythema and slight edema, within 24 hours, symptoms of allergic increases the weight of, and sensitization rate is 100%, test group and blank treated animal Skin does not all occur that any symptoms of allergic, sensitization rate are 0%.Test result indicate that the mouthwash formula gentleness nothing of the present invention Stimulate.

Embodiment 6 bacteriostatic experiment

1, experimental strain: beta hemolytic streptococcus (CICC 10373)

2, bacterium culture medium: blood plate and nutrient broth medium.

3, bacteriostatic experiment divides three experimental grouies and negative control group, and experimental group A is the collutory of gained in embodiment 1, real Testing group B is the collutory of gained in embodiment 2, and experimental group C is the collutory of gained in embodiment 3, and negative control group is blank Comparison.

4, specific experiment step:

(1) prepared by susceptibility sense sheet: double-round board qualitative filter paper card punch is made the round scraps of paper of diameter 6mm and put into cleaning and be dried Penicillin empty bottle in, bottleneck is wrapped up with monolayer kraft paper, 121 DEG C of autoclaving 30min, then through 100 DEG C of drying, airtight preservation Standby.The most respectively the scraps of paper are soaked in 2h in the collutory of embodiment 1 to 3, treat that liquid is absorbed by the scraps of paper completely After, take out filter paper, it is standby that susceptibility sheet is made in 50 DEG C of drying, and 5 susceptibility sense sheets prepared by every kind of unguentum, prepare 5 skies simultaneously The scraps of paper of white sterilizing are as negative control group；

(2) prepare bacterium solution: beta hemolytic streptococcus strain is placed in 10ml nutrient broth medium, cultivate 18h for 37 DEG C； Take 0.9% aseptic sodium chloride solution that culture fluid 1ml adds 9ml, use 10 times of incremental dilution methods, be diluted to 105～106cfu/ Ml, standby；

(3) the test bacterium solution that above-mentioned steps (2) prepares uniformly is inoculated on blood plate, left at room temperature 5min, will step Suddenly the 15 susceptibility sense sheets and the 5 blank sterilizing scraps of paper that prepare in (1) are laid on this blood plate, and flat board is inverted into cultivation In case after 37 DEG C of cultivation 24h, measure the antibacterial circle diameter (mm) of each susceptibility sheet, calculate the antibacterial circle diameter meansigma methods of each group, with Upper operation is sterile working.

5, experimental observation is measured:

Observe: represent with "-" without inhibition zone；

Antibacterial circle diameter ＜ 10mm is the most antibacterial, with "+" represent；

Antibacterial circle diameter 10～14mm is that moderate is antibacterial, represents with " ++ "；

Antibacterial circle diameter ＞ 14mm is that height is antibacterial, represents with " +++ "；

	Negative control	Experimental group A	Experimental group B	Experimental group C
					Inhibitory action	-	++	++	+++

Test result indicate that, the collutory of the present invention has more significant fungistatic effect, can play the most antibacterial pressing down Bacterium effect.

The above, the only explanation embodiment of the present invention, not the present invention is appointed and formal and substantial restriction, It should be pointed out that, for those skilled in the art, on the premise of without departing from the inventive method, that makes some changes Enter and supplement and also should be regarded as protection scope of the present invention.All those skilled in the art, in the spirit without departing from the present invention In the case of scope, utilize a little change that disclosed above technology contents is made, the equivalent variations modified and develop, all Equivalent embodiments for the present invention；Meanwhile, what above-described embodiment was done by the substantial technological of all foundation present invention appoints and equivalent change Change change, modify and develop, all still fall within the scope of technical scheme.It is existing at the most detailed disclosure of the present invention Technology.

Claims

1. an anti-inflammation collutory, it is characterised in that raw material and the mass percent thereof of making described collutory be: Chinese medicine Extract 45-60%, food-grade ethanol 9-12%, Tween 80 2.0-2.4%, sorbic acid 15-18%, essence 0.7-0.9%, Surplus is deionized water；Raw material and the parts by weight thereof of making described Chinese medicine extract are: Flos Rosae Rugosae 25-30 part, white residual flower 4-8 Part, Flos Lonicerae 15-20 part, Herba Houttuyniae 6-12 part, Fructus Forsythiae 8-13 part, Herba Tagetis Patulae 3-6 part, Fructus Toosendan 2-4 part, Cortex Magnoliae Officinalis 6-8 part, five Gall nut 10-15 part, Radix Ilicis Asprellae 4-6 part, Rhizoma Polygoni Cuspidati 6-8 part, Radix Bupleuri 8-12 part, green lemon fresh goods 28-35 part, Radix Paeoniae Alba 7-10 part is blue Eucalyptus globulus 8-12 part, Radix Glycyrrhizae Preparata 6-9 part.

2. a kind of anti-inflammation collutory as claimed in claim 1, it is characterised in that make the raw material of described Chinese medicine extract And parts by weight are: Flos Rosae Rugosae 25 parts, white residual flower 4 parts, Flos Lonicerae 15 parts, Herba Houttuyniae 6 parts, Fructus Forsythiae 8 parts, Herba Tagetis Patulae 3 parts, river Chinaberry 2 parts, Cortex Magnoliae Officinalis 6 parts, Galla Chinensis 10 parts, Radix Ilicis Asprellae 4 parts, Rhizoma Polygoni Cuspidati 6 parts, Radix Bupleuri 8 parts, green lemon fresh goods 28 parts, the Radix Paeoniae Alba 7 parts, Eucalyptus globulus Labill 8 parts, Radix Glycyrrhizae Preparata 6 parts.

3. a kind of anti-inflammation collutory as claimed in claim 1, it is characterised in that make the raw material of described Chinese medicine extract And parts by weight are: Flos Rosae Rugosae 30 parts, white residual flower 8 parts, Flos Lonicerae 20 parts, Herba Houttuyniae 12 parts, Fructus Forsythiae 13 parts, Herba Tagetis Patulae 6 parts, Fructus Toosendan 4 parts, Cortex Magnoliae Officinalis 8 parts, Galla Chinensis 15 parts, Radix Ilicis Asprellae 6 parts, Rhizoma Polygoni Cuspidati 8 parts, Radix Bupleuri 12 parts, green lemon fresh goods 35 parts, the Radix Paeoniae Alba 10 Part, Eucalyptus globulus Labill 12 parts, Radix Glycyrrhizae Preparata 9 parts.

4. a kind of anti-inflammation collutory as claimed in claim 1, it is characterised in that make the raw material of described Chinese medicine extract And parts by weight are: Flos Rosae Rugosae 27 parts, white residual flower 6 parts, Flos Lonicerae 18 parts, Herba Houttuyniae 9 parts, Fructus Forsythiae 11 parts, Herba Tagetis Patulae 5 parts, Fructus Toosendan 3 parts, Cortex Magnoliae Officinalis 7 parts, Galla Chinensis 12 parts, Radix Ilicis Asprellae 5 parts, Rhizoma Polygoni Cuspidati 7 parts, Radix Bupleuri 10 parts, green lemon fresh goods 31 parts, the Radix Paeoniae Alba 8 Part, Eucalyptus globulus Labill 10 parts, Radix Glycyrrhizae Preparata 7 parts.

5. anti-inflammation collutory as claimed in claim 1 a kind of, it is characterised in that make described collutory raw material and Mass percent is: Chinese medicine extract 50%, food-grade ethanol 10%, Tween 80 2.2%, sorbic acid 16%, essence 0.8%, Deionized water 21%.

6. the preparation method of a kind of anti-inflammation collutory as according to any one of claim 1 to 5, it is characterised in that bag Include following steps:

(1) Flos Rosae Rugosae, white residual flower, Flos Lonicerae, Herba Houttuyniae, Fructus Forsythiae, Herba Tagetis Patulae, Fructus Toosendan, Cortex Magnoliae Officinalis, Galla Chinensis, Radix Ilicis Asprellae, tiger Cane, Radix Bupleuri, the Radix Paeoniae Alba, Eucalyptus globulus Labill, Radix Glycyrrhizae Preparata co-grinding obtain 50 mesh mixed-powders, and gained mixed-powder adds gross mass multiple 4 times Water soaking 1 hour, slow fire boiling 1 hour, cross 100 mesh drainage screen separation filtering residues, filtrate after decoction, gained filtrate is cooled to room Temperature is standby；

(2) green lemon cleans rear cutout fritter, adds and crosses 100 mesh drainage screens after standing 0.5 hour after step (1) gained filtrate is squeezed the juice Separate filtering residue, filtrate；

(3) water logging of mixing filtering residue gross mass multiple 4 times is added with step (2) gained filtering residue after step (1) gained filtering residue mixes Steeping 0.5 hour, slow fire boiling is crossed 100 mesh drainage screens after 1 hour and is obtained filtrate, and it is standby that gained filtrate is cooled to room temperature；

(4) step (2) gained filtrate and step (3) gained filtrate mixing and stirring i.e. obtain Chinese medicine extract, and gained Chinese medicine carries Take thing addition food-grade ethanol, Tween 80, sorbic acid, essence and ionized water mixing and stirring and i.e. obtain anti-inflammation collutory.