CN107889857A

CN107889857A - A kind of preparation method for killing thrips pharmaceutical composition

Info

Publication number: CN107889857A
Application number: CN201711094575.4A
Authority: CN
Inventors: 黄伟
Original assignee: Chengdu Aibike Biotechnology Co Ltd
Current assignee: Chengdu Aibike Biotechnology Co Ltd
Priority date: 2017-11-09
Filing date: 2017-11-09
Publication date: 2018-04-10

Abstract

The invention discloses a kind of preparation method for the pharmaceutical composition for killing thrips, comprise the steps：1）Prepare raw material；2）The tuber of stemona, Chinese prickly ash, camphor add water to cook secondary, and decoction is standby；3）Chinese wampee root, nutmeg, bark of ash, cucumber benevolence grass, radix polygonati officinalis, the young leaf of thief add water to cook secondary, filtration, and filtrate is concentrated into relative density as 1.15；4）Merge decoction；5）Adjust solution ph；6）Filtering, it is filling, sterilizing, produce.Heretofore described pharmaceutical composition can targetedly combination for killing thrips, security is good, biodegradable good, pollution-free and penetrating odor, no environment toxic action, noresidue in animal body, does not destroy the ecological balance, crop growth environment is influenceed small；With preferable permeability and wettability, the central nervous system of polypide is disturbed, suppresses worm's ovum synthesis development, is not susceptible to drug resistance；Quick-acting is good, is adapted to the wide popularization and application in terms of control of insect.

Description

A kind of preparation method for killing thrips pharmaceutical composition

Technical field

The invention belongs to agricultural technology development field, in particular it relates to a kind of preparation side for killing thrips pharmaceutical composition Method.

Background technology

Chemical agent plays an important role in terms of crop pest control, but the residual of medicine causes nature The ecosystem is worsening, and this has turned into international common concern and key subjects urgently to be resolved hurrily.Since China, twentieth century Because single use chemical pesticide causes agricultural product harmful element exceeded, health and the existence of the people are directly endangered, therefore, state Family pays much attention to and formulated《Medium-term and long-term scientific and technical development program outline》, it is therefore intended that encourage research and development environment-friendly type fertilizer, agriculture Medicine." seeking speed " psychology of current peasant is incompatible, and most farmers are still selected using high poison, the chemical pesticide of high residue, this Chemical pesticide can use only for crop, i.e., kill each class pest for certain crop simultaneously.But this chemical pesticide exists Today of green and environmental protection is advocated, a variety of high poisons and high residue chemicals are limited the quantity or stopped production, further, since insect The difference of species, cause each class pest to occur larger difference in terms of the resistance to the action of a drug and drug resistance, so just make killing for chemical agent Easily there is resistance insect in worm effect, therefore propose to prevent specific insect from just seeming for the insect-proof agent of different insects to have very much must Will, but yet there are no corresponding report.

The content of the invention

The technical problems to be solved by the invention are to provide that a kind of preparation process is simple, and manufacturing cost is cheap, process Maturation, the preparation method for the killing thrips pharmaceutical composition that can produce in enormous quantities.

Technical scheme is used by the present invention solves above-mentioned technical problem：A kind of system for the pharmaceutical composition for killing thrips Preparation Method, comprise the steps：

(1) pharmaceutical composition raw medicinal material tuber of stemona 60g, Chinese prickly ash 70g, the camphor 50g of thrips, Chinese wampee root 100g, meat are killed Cardamom 200g, bark of ash 120g, cucumber benevolence grass 150g, radix polygonati officinalis 100g, thief young leaf 250g, cycloprothrin 15g；

(2) tuber of stemona, Chinese prickly ash, camphor add water to cook secondary, 2 hours every time, collecting decoction, add ethanol filtering and concentrating, add 2 times Water is measured, is sufficiently stirred, is refrigerated 48 hours, filtration, it is about 1.30 that filtrate decompression, which is concentrated into relative density, and decoction is standby；

(3) Chinese wampee root, nutmeg, bark of ash, cucumber benevolence grass, radix polygonati officinalis, the young leaf of thief add water to cook secondary, 0.5 hour every time, close And decocting liquid, filtration, filtrate is concentrated, is let cool, it is 65% to add ethanol to make containing amount of alcohol, stands overnight, filters, filtrate decompression is concentrated into Relative density is 1.35, and it is 70% to add ethanol to make containing amount of alcohol, stands overnight, filters, and it is 1.30 that filtrate, which is concentrated into relative density, Adding 3 times of amount water, be sufficiently stirred, refrigerate 48 hours, filtration, it is 1.15 that filtrate, which is concentrated into relative density,

(4) merge with above-mentioned all decoctions, add 2 times of amount water, be sufficiently stirred, refrigerate 24 hours, filtration, filtrate adds second cyanogen Chrysanthemum ester and deionized water water are configured to 1000ml solution, stir evenly, relatively close when the relative density of above-mentioned each filtrate is 80 DEG C Degree；

(5) solution ph is adjusted to 6.5-8.5 with sodium hydroxide solution；

(6) filter, it is filling, sterilizing, produce.

In order to which the method for the present invention is better achieved, further, in the step (2), add the mistake of ethanol filtering and concentrating Cheng Wei, first filter to get filtrate, filtrate decompression is concentrated into relative density as 1.20~1.30, lets cool, add ethanol make be containing amount of alcohol 65%, stand overnight, filter, decompression filtrate recycling ethanol is simultaneously concentrated into relative density as 1.30.

In order to which the method for the present invention is better achieved, further, in the step (3), filtrate is concentrated into relative density For 1.25~1.35.

In order to which the method for the present invention is better achieved, further, in the step (5), the sodium hydroxide solution that uses Mass percent be 20%.

In order to which the method for the present invention is better achieved, further, in the step (6), solution uses miillpore filter mistake Filter.

The present invention compared with prior art, has with advantage and beneficial effect：

(1) it is good can to prepare security for preparation method of the present invention, biodegradable good, pollution-free and penetrating odor, Without environment toxic action, noresidue in animal body, the ecological balance is not destroyed, crop growth environment is influenceed small；

(2) preparation method of the present invention, preparation process is simple, and manufacturing cost is cheap, the pharmaceutical composition being prepared With preferable permeability and wettability, thrips wax coat is easily broken through, depth destroys the epidermal structure of polypide and internal egg White matter, thrips is set to be not susceptible to drug resistance；

(4) preparation method of the present invention can improve the quick-acting of combination for killing thrips pharmaceutical composition, the pharmaceutical composition When acting on thrips, thrips can be made to stop eating in 20~40 minutes death；

(5) its mature preparation process of preparation method of the present invention, it can be used for the medicine for producing combination for killing thrips in batches Composition, it is adapted to the wide popularization and application in terms of control of insect.

Embodiment

For the purpose of the present invention, process conditions and advantage effect is more clearly understood, with reference to following embodiment, to this Invention is described in further detail, but the implementation of the present invention is not limited to this, is not departing from the above-mentioned technological thought feelings of the present invention Under condition, according to ordinary skill knowledge and customary means, various replacements and change are made, the model of the present invention all should be included in In enclosing, specific implementation example described herein is not intended to limit the present invention only to explain the present invention.

Embodiment 1：

The present embodiment provides a kind of pharmaceutical composition for killing thrips, including Radix Stemonae extract, pepper extract, camphor carry Thing, Calusena lansium root extract, Semen Myristicae extract, Radix Gentianae Macrophyllae extract, cucumber benevolence grass extract, Rhizoma Polygonati Odorati extract, the young leaf of thief is taken to carry Thing and cycloprothrin are taken, its component is as follows：

Its preparation method：The tuber of stemona, Chinese prickly ash, camphor add water to cook it is secondary, 2 hours every time, collecting decoction, add ethanol filtering it is dense Contracting, add 2 times of amount water, be sufficiently stirred, refrigerate 48 hours, filtration, it is about 1.30 that filtrate decompression, which is concentrated into relative density, and decoction is standby With；Chinese wampee root, nutmeg, bark of ash, cucumber benevolence grass, radix polygonati officinalis, the young leaf of thief add water to cook it is secondary, 0.5 hour every time, collecting decoction, Filtration, filtrate is concentrated, is let cool, it is 65% to add ethanol to make containing amount of alcohol, stands overnight, filters, filtrate decompression is concentrated into relatively close Spend for 1.35, it is 70% to add ethanol to make containing amount of alcohol, stands overnight, filters, and filtrate is concentrated into relative density as 1.30, adds 3 times Water is measured, is sufficiently stirred, is refrigerated 48 hours, filtration, filtrate is concentrated into relative density as 1.15；Merge with above-mentioned all decoctions, add 2 Amount water again, is sufficiently stirred, and refrigerates 24 hours, and filtration, filtrate adds cycloprothrin and deionized water water is configured to 1000ml solution, Stir evenly, the relative density when relative density of above-mentioned each filtrate is 80 DEG C；With sodium hydroxide solution adjust solution ph to 6.5-8.5；Filtering, it is filling, sterilizing, produce.

Wherein, the process for adding ethanol filtering and concentrating is first to filter to get filtrate, and filtrate decompression is concentrated into relative density as 1.27 ~1.30, let cool, it is 65% to add ethanol to make containing amount of alcohol, stands overnight, filters, and decompression filtrate recycling ethanol is simultaneously concentrated into relative Density is 1.30.Filtrate is concentrated into relative density as 1.25~1.35.The mass percent of the sodium hydroxide solution used is 20%.Solution uses filtering with microporous membrane.

Embodiment 2：

The present embodiment verifies that the pharmaceutical composition insecticide common with market is compared, to the eradicative rate of thrips.

Choose insecticide common on the market：Pale purple purple spore bacterium aqua, nematode killing agent, the agent of special efficacy root line, thiamethoxam disinsection agent.

It is grouped according to different insecticides, every group prepares in worm's ovum, larva, the thrips of going out of adult three phases respectively Each 1000, insecticide is then used respectively to the thrips in each stage, tests the eradicative rate of every group of insecticide, such as following table It is shown：

Killing effect of the insecticide of table one to thrips

As seen from the above table, each group insecticide is the most excellent to larval thrips killing rate highest, the insecticidal effect of this product Good, insect killing effect is notable, and the worm's ovum for being most difficult to kill also has preferable insect killing effect.

Embodiment 3：

The present embodiment verifies eradicative rate of the pharmaceutical composition to various insects.

It is each to choose chafer, beetle, leafhopper, heart-eating worm, pear sucker, scale insect, volume noctuid, mole cricket, fore-telling mud, thrips 10000, and be grouped respectively, the decoction of same concentrations is made in the medicine being prepared using embodiment 1, respectively the evil to every group Worm is sprayed, and after 1 hour, checks the eradicative rate of various insects, as a result as shown in the table：

Insect killing effect of the medicine of table two to various insects

Group	Eradicative rate (%)
		Thrips	99.77
Chafer	10.32
		Beetle	9.65
Leafhopper	8.75
		Heart-eating worm	1.02
Pear sucker	0
		Scale insect	0
Roll up noctuid	1.01
		Mole cricket	0
Foretell mud	1.24

As seen from the above table, the medicine that embodiment 1 is prepared, only there is preferable insect killing effect to thrips, to other insects Insect killing effect it is very limited, thus its specific aim of provable this product is stronger, is only capable of using and being killed for thrips.

Claims

A kind of 1. preparation method for the pharmaceutical composition for killing thrips, it is characterised in that：Comprise the steps：

（1）Kill pharmaceutical composition raw medicinal material tuber of stemona 60g, Chinese prickly ash 70g, the camphor 50g of thrips, Chinese wampee root 100g, nutmeg 200g, bark of ash 120g, cucumber benevolence grass 150g, radix polygonati officinalis 100g, thief young leaf 250g, cycloprothrin 15g；

（2）The tuber of stemona, Chinese prickly ash, camphor add water to cook secondary, 2 hours every time, collecting decoction, add ethanol filtering and concentrating, add 2 times of amounts Water, it is sufficiently stirred, refrigerates 48 hours, filtration, it is about 1.30 that filtrate decompression, which is concentrated into relative density, and decoction is standby；

（3）Chinese wampee root, nutmeg, bark of ash, cucumber benevolence grass, radix polygonati officinalis, the young leaf of thief add water to cook secondary, 0.5 hour every time, merge and decoct Liquid, filtration, filtrate is concentrated, is let cool, it is 65% to add ethanol to make containing amount of alcohol, stands overnight, filters, filtrate decompression is concentrated into relatively Density is 1.35, and it is 70% to add ethanol to make containing amount of alcohol, stands overnight, filters, it is 1.30 that filtrate, which is concentrated into relative density, adds 3 Amount water again, is sufficiently stirred, and refrigerates 48 hours, filtration, and filtrate is concentrated into relative density as 1.15；

（4）Merge with above-mentioned all decoctions, add 2 times of amount water, be sufficiently stirred, refrigerate 24 hours, filtration, filtrate adds cycloprothrin 1000ml solution is configured to deionized water water, is stirred evenly, the relative density when relative density of above-mentioned each filtrate is 80 DEG C；

（5）Solution ph is adjusted to 6.5-8.5 with sodium hydroxide solution；

（6）Filtering, it is filling, sterilizing, produce.
A kind of 2. preparation method of pharmaceutical composition for killing thrips according to claim 1, it is characterised in that the step Suddenly（2）In, the process for adding ethanol filtering and concentrating is first to filter to get filtrate, filtrate decompression be concentrated into relative density for 1.20~ 1.30, let cool, it is 65% to add ethanol to make containing amount of alcohol, stands overnight, filters, decompression filtrate recycling ethanol is simultaneously concentrated into relatively close Spend for 1.30.
A kind of 3. preparation method of pharmaceutical composition for killing thrips according to claim 1, it is characterised in that the step Suddenly（3）In, filtrate is concentrated into relative density as 1.25~1.35.
A kind of 4. preparation method of pharmaceutical composition for killing thrips according to claim 1, it is characterised in that the step Suddenly（5）In, the mass percent of the sodium hydroxide solution used is 20%.
A kind of 5. preparation method of pharmaceutical composition for killing thrips according to claim 1, it is characterised in that the step Suddenly（6）In, solution uses filtering with microporous membrane.