CN111420016A

CN111420016A - Plaster and preparation method thereof

Info

Publication number: CN111420016A
Application number: CN202010296303.8A
Authority: CN
Inventors: 畅君周
Original assignee: Zhengzhou Junhuitang Pharmaceutical Technology Co ltd
Current assignee: Zhengzhou Junhuitang Pharmaceutical Technology Co ltd
Priority date: 2020-04-15
Filing date: 2020-04-15
Publication date: 2020-07-17

Abstract

The invention relates to a traditional Chinese medicine patch, in particular to a plaster and a preparation method thereof, wherein the plaster is prepared from the following raw materials, by weight, 18-23 parts of white mustard seed, 18-23 parts of corydalis tuber, 1-23 parts of centipeda minima, 8-12 parts of kansui root, 8-12 parts of asarum, 8-12 parts of ephedra, 18-23 parts of dried ginger, 8-12 parts of schisandra fruit, 3-7 parts of cinnamon, 3-7 parts of fennel, 3-7 parts of bulbus fritilariae, 13-17 parts of honeysuckle, 13-17 parts of weeping forsythia, 18-23 parts of liquorice, 3-7 parts of schizonepeta spike, 18-23 parts of burdock, 18-23 parts of lophatherum gracile, 18-23 parts of pinellia tuber, 8-12 parts of agilawood, 20-25 parts of almond, 27-33 parts of radix stemonae, 27-33 parts of datura flower, 8-12 parts of, 21-27 parts of stiff silkworm, better effect, no side effect and convenient use when used for external application.

Description

Plaster and preparation method thereof

Technical Field

The invention relates to the field of medicines, and in particular relates to a plaster and a preparation method thereof.

Background

With the development of science and technology, the living standard of people is increasingly improved, however, due to the reduction of environmental quality and the factors of high living pressure, overtime, night stay and the like, the physical quality of people is reduced, symptoms such as headache and brain heat and the like often appear, particularly, children have weak resistance and are easy to get ill, cold and cough are common symptoms in life, many doctors usually adopt western medicines for treating the symptoms, and a dripping mode is seriously adopted, however, the internal administration method is not ideal in curative effect sometimes, and also brings about many side effects such as sleeping and unconsciousness. The invention responds to the national advocated health of the whole people, does not abuse antibiotics, develops the technology of the traditional Chinese medicine, promotes the use method of the traditional Chinese medicine, plays the role of external treatment of internal diseases and targeted drug delivery by acupoint application, highlights the characteristics of the traditional Chinese medicine, has the characteristics of quick response, short treatment course and no side effect, and leads the acupoint application of the traditional Chinese medicine to go out of China.

Disclosure of Invention

The plaster prepared by the reasonable formula is used for external administration, has better effect, does not bring any side effect and is convenient to use.

The aim of the invention is achieved by the following measures: a plaster is prepared from the following raw materials, by weight, 18-23 parts of white mustard seed, 18-23 parts of corydalis tuber, 1-23 parts of centipeda minima, 8-12 parts of euphorbia kansui, 8-12 parts of asarum, 8-12 parts of ephedra, 18-23 parts of dried ginger, 8-12 parts of schisandra chinensis, 3-7 parts of cinnamon, 3-7 parts of fennel, 3-7 parts of bulbus fritillariae cirrhosae, 13-17 parts of honeysuckle, 13-17 parts of fructus forsythiae, 18-23 parts of liquorice, 3-7 parts of schizonepeta spike, 18-23 parts of burdock, 18-23 parts of lophatherum gracile, 18-23 parts of pinellia ternate, 8-12 parts of agilawood, 20-25 parts of almond, 27-33 parts of radix stemonae, 27-33 parts of datura flower, 8-12 parts of borneol, 27-33 parts of mint and 21-27 parts.

Furthermore, the traditional Chinese medicine composition is prepared from the following raw materials, by weight, 19-21 parts of white mustard seed, 20-22 parts of corydalis tuber, 10-17 parts of centipeda minima, 9-10 parts of euphorbia kansui, 9-10 parts of asarum, 10-12 parts of ephedra, 20-22 parts of dried ginger, 10-12 parts of schisandra chinensis, 4-6 parts of cinnamon, 5-7 parts of fennel, 3-4 parts of bulbus fritillariae cirrhosae, 15-16 parts of honeysuckle, 14-16 parts of fructus forsythiae, 20-22 parts of liquorice, 4-6 parts of schizonepeta spike, 20-21 parts of burdock, 20-22 parts of lophatherum gracile, 21-23 parts of pinellia ternate, 9-10 parts of agilawood, 23-25 parts of almond, 30-32 parts of radix stemonae, 30-31 parts of datura flower, 10-12 parts of borneol, 30-32 parts of mint and.

Further, 20 parts of white mustard seed, 20 parts of corydalis tuber, 20 parts of centipeda minima, 10 parts of kansui root, 10 parts of asarum, 10 parts of ephedra, 20 parts of dried ginger, 10 parts of schisandra chinensis, 5 parts of cinnamon, 5 parts of fennel, 5 parts of bulbus fritilariae, 15 parts of honeysuckle, 15 parts of fructus forsythiae, 20 parts of liquorice, 10 parts of schizonepeta spike, 20 parts of burdock, 20 parts of lophatherum gracile, 20 parts of pinellia ternate, 10 parts of agilawood, 22 parts of almond, 30 parts of radix stemonae, 30 parts of flos daturae, 10 parts of borneol, 30 parts of mint and 24 parts of stiff silkworm.

A preparation method of plaster comprises the following steps,

step one, putting semen brassicae, rhizoma corydalis, centipeda minima, euphorbia kansui, asarum, ephedra, rhizoma zingiberis, schisandra chinensis, cinnamon, fennel, bulbus fritillariae cirrhosae, honeysuckle, fructus forsythiae, liquorice, schizonepeta spike, burdock, lophatherum gracile, pinellia ternate, agilawood, almond, radix stemonae, flos daturae and stiff silkworm into a mixer to be mixed for 30min to obtain a mixture;

step two, uniformly dividing the mixed powder obtained in the step one into three parts, namely a first part of mixed material, a second part of mixed material and a third part of mixed material;

step three, adding water with the weight 8-10 times of that of the first mixture, soaking for 2-3h, boiling with strong fire, then boiling with slow fire for 30-35min, cooling to room temperature, and filtering to obtain primary filtrate and primary medicine residue;

step four, adding 2-3 times of water by weight of the primary medicine residues, soaking for 2-3 hours, boiling with strong fire, then boiling with slow fire for 30-35min, cooling to room temperature, and filtering to obtain secondary filtrate and secondary medicine residues;

step five, adding 2-3 times of water by weight of the secondary medicine residues, soaking for 2-3h, boiling with strong fire, then boiling with slow fire for 30-35min, cooling to room temperature, and filtering to obtain tertiary filtrate and tertiary medicine residues;

step six, merging the primary filtrate, the secondary filtrate and the tertiary filtrate, concentrating into paste to obtain paste for later use, and fully exerting the effective components of the medicaments by decocting to quickly remove diseases;

step seven, adding 3 times of ethanol into the second mixture, sealing and soaking, filtering after 48-50 hours to obtain primary ethanol liquid and primary soaking medicine residues;

step eight, adding 1.5 times of ethanol into the secondary soaking dregs, sealing and soaking, filtering after 48-50h to obtain secondary ethanol liquid and secondary soaking dregs;

step nine, adding 1.5 times of ethanol by weight into the three times of the soaking dregs, sealing and soaking, filtering after 48-50h to obtain three times of ethanol solution and three times of the soaking dregs;

the sealed impregnation can promote the release of the effective components of the medicine, increase the release and dissolution amount of the effective components of the medicine, thereby increasing the utilization rate of the effective components of the medicine, the ethanol can prevent the liquid medicine and the effective components of the medicine from going bad or going mouldy,

step ten, merging the primary ethanol solution, the secondary ethanol solution and the tertiary ethanol solution, and concentrating the film to 2.1-2.5g/ml to obtain emulsion for later use;

step eleven, crushing the third mixture to 300 meshes to obtain mixed powder for later use;

the traditional Chinese medicine is subjected to superfine grinding, so that the contact area of the medicine is larger, the effective ingredients of the medicine are released more, the effective ingredients of the medicine can be more durable, the effective ingredients of the medicine can act on the durability by being applied to acupuncture points, better penetrability and lipid solubility are achieved, the curative effect is better and more stable, and the effect of treating both symptoms and root causes is achieved,

and step twelve, putting the ointment, the emulsion and the mixed powder into a stirring tank, mixing for 10-15min at the rotation speed of 200-.

Further, in the first step, mixing was performed using a V-type mixer.

In the invention, the white mustard seed has the effects of warming lung, eliminating phlegm, benefiting qi, dredging collaterals and relieving pain; rhizoma corydalis has effects of promoting blood circulation, removing blood stasis, regulating qi-flowing, and relieving pain; herba Centipedae can disperse wind-cold, relieve nasal obstruction, relieve cough, and remove toxic substance; gan sui purges water and dispels swelling, detumescence and dissipating nodulation; herba asari has effects in relieving exterior syndrome, dispelling cold, expelling pathogenic wind, relieving pain, inducing resuscitation, warming lung, and eliminating phlegm; ephedra stem has the effects of inducing sweat, relieving exterior syndrome, ventilating and smoothing lung, relieving asthma, inducing diuresis and relieving swelling; the dried ginger has the effects of warming the middle-jiao to dispel cold, restoring yang to promote blood circulation, warming the lung and resolving fluid retention; fructus Schisandrae chinensis has effects in astringing lung, nourishing kidney, promoting fluid production, arresting spontaneous emission, and treating cough and asthma due to lung deficiency; cinnamon is pungent and warm in flavor, mainly treats all diseases, nourishes spirit, harmonizes color, benefits joints, tonifies middle-jiao and tonifies qi; the fennel has the effects of dispelling cold, relieving pain, regulating qi and harmonizing stomach; bulbus Fritillariae Cirrhosae moistening lung, relieving cough and eliminating phlegm, relieving asthma, clearing heat and eliminating phlegm; honeysuckle flower has the effects of clearing away heat and toxic materials, warming disease, fever, heat-toxin and bloody dysentery, carbuncle, cellulitis and furuncle; lian Yi is heat-clearing and detoxicating, resolving carbuncle and dissipating binds; the liquorice tonifies spleen and qi, clears away heat and toxic materials, eliminates phlegm and stops coughing, relieves spasm and pain, and harmonizes the medicines; herba Schizonepetae has effects in relieving exterior syndrome, dispelling pathogenic wind, promoting eruption, and eliminating sore; fructus Arctii has effects of dispelling pathogenic wind and heat, dispersing lung qi, promoting eruption, relieving swelling, and removing toxic substance; folium Bambusae fever with polydipsia, aphtha, dark urine, pyretic stranguria and odynuria; pinellia tuber has effects of eliminating dampness and phlegm, lowering adverse qi, relieving vomit, relieving distension and fullness, and resolving hard mass, and can be used for treating excessive phlegm and cough and asthma; lignum Aquilariae Resinatum has effects of activating qi-flowing, relieving pain, warming middle warmer, relieving vomit, and promoting inspiration to relieve asthma; the almond has the functions of depressing qi and relieving cough and asthma; radix Stemonae has effects of moistening lung and relieving cough; flos Daturae Metelis has antitussive, antiasthmatic, analgesic, and tranquilizing effects; borneol has faint scent, and has effects of inducing resuscitation, refreshing mind, clearing heat and removing toxic substances; bombyx Batryticatus has effects of resolving hard mass and relieving swelling.

The invention has the beneficial effects that: the mutual matching can achieve better curative effects of relieving cough and asthma, dispelling wind and removing dampness, warming channel and dispelling cold, eliminating phlegm and relieving cough, freeing lung and relieving asthma, and treating cold, cough, pharyngitis, acute laryngeal disease, asthma, laryngeal guan carbuncle and aphonia. Asarum herb can resolve phlegm outside the skin, search wind outside the skin, and disperse cold outside the skin and membrane; menthol and borneol can promote the percutaneous absorption of the medicine, and the plaster has better curative effects on cold, cough, pharyngitis, laryngeal abscess, asthma, laryngeal obstruction abscess and aphonia. On the basis of a large number of clinical experiments, the traditional Chinese medicine has the advantages of being green, safe, quick in effect, short in treatment course, low in cost, capable of reducing side effects on human bodies and free of pain in curing. And the cold and cough are common diseases and frequently encountered diseases of the people, and the cold and cough can be cured through acupuncture point treatment and acupuncture point application, so that the plaster has a good prospect.

Detailed Description

The process for preparing a plaster of the following examples, comprising the steps of,

The raw materials are processed in three modes, components to be used of the raw materials can be extracted, meanwhile, the raw materials can be mixed with each other to obtain a finished product ointment body, other auxiliary agents are not added, the ointment can be prepared conveniently, toxic and side effects caused by the addition of other chemical reagents are avoided, the medicinal components are distributed uniformly, and the using effect can be improved.

In the above steps, the mixer in the first step is a three-dimensional mixer;

step seven, step eight and step nine, the ethanol used in the step is medical ethanol with the concentration of 70-80%;

and the stirring tank in the step twelve is a sterilization stirring tank, and the sterilization effect can be ensured by the double functions of stirring tank sterilization and ethanol sterilization, so that the active ingredients of the liquid medicine and the medicament are prevented from going bad or going mouldy.

Example 1

A plaster is prepared from the following raw materials, by weight, 18g of white mustard seed, 20g of corydalis tuber, 9g of centipeda minima, 10g of euphorbia kansui, 9g of asarum, 11g of ephedra, 22g of dried ginger, 9g of schisandra chinensis, 4g of cinnamon, 5g of fennel, 4g of bulbus fritilariae, 15g of honeysuckle, 16g of fructus forsythiae, 21g of liquorice, 4g of schizonepeta spike, 20g of burdock, 20g of lophatherum gracile, 19g of pinellia ternate, 11g of agilawood, 24g of almond, 31g of radix stemonae, 30g of flos daturae, 10g of borneol, 31g of mint and 24g of.

Example 2

A plaster is prepared from the following raw materials, by weight, 20g of white mustard seed, 20g of corydalis tuber, 20g of centipeda minima, 10g of euphorbia kansui, 10g of asarum, 10g of ephedra, 20g of dried ginger, 10g of schisandra chinensis, 5g of cinnamon, 5g of fennel, 5g of bulbus fritilariae, 15g of honeysuckle, 15g of fructus forsythiae, 20g of liquorice, 10g of schizonepeta spike, 20g of burdock, 20g of lophatherum gracile, 20g of pinellia ternate, 10g of agilawood, 22g of almond, 30g of radix stemonae, 30g of flos daturae, 10g of borneol, 30g of mint and 24g of.

Example 3

A plaster is prepared from the following raw materials, by weight, 21g of white mustard seed, 21g of corydalis tuber, 14g of centipeda minima, 9g of euphorbia kansui, 11g of asarum, 8g of ephedra, 19g of dried ginger, 11g of schisandra chinensis, 7g of cinnamon, 3g of fennel, 6g of bulbus fritilariae, 13g of honeysuckle, 13g of fructus forsythiae, 18g of liquorice, 7g of schizonepeta spike, 21g of burdock, 22g of lophatherum gracile, 23g of pinellia ternate, 8g of agilawood, 20g of almond, 27g of radix stemonae, 28g of datura flower, 9g of borneol, 28g of mint and 21g of.

Example 4

A plaster is prepared from the following raw materials, by weight, 21g of white mustard seed, 20g of corydalis tuber, 12g of centipeda minima, 9g of euphorbia kansui, 10g of asarum, 10g of ephedra, 20g of dried ginger, 10g of schisandra chinensis, 5g of cinnamon, 6g of fennel, 3g of bulbus fritilariae, 15g of honeysuckle, 16g of fructus forsythiae, 22g of liquorice, 4g of schizonepeta spike, 21g of burdock, 21g of lophatherum gracile, 22g of pinellia ternate, 9g of agilawood, 25g of almond, 25g of radix stemonae, 31g of flos daturae, 11g of borneol, 32g of mint and 26g of.

Example 5

A plaster is prepared from the following raw materials, by weight, 20g of white mustard seed, 21g of corydalis tuber, 5g of centipeda minima, 9g of euphorbia kansui, 9g of asarum, 10g of ephedra, 22g of dried ginger, 11g of Chinese magnoliavine fruit, 4g of cinnamon, 6g of common fennel fruit, 3g of bulbus fritilariae, 15g of honeysuckle, 14g of fructus forsythiae, 22g of liquorice, 6g of schizonepeta spike, 20g of great burdock achene, 22g of lophatherum gracile, 22g of pinellia ternate, 9g of agilawood, 25g of almond, 32g of radix stemonae, 31g of flos daturae, 12g of borneol.

Example 6

A plaster is prepared from the following raw materials, by weight, 21g of white mustard seed, 22g of corydalis tuber, 15g of centipeda minima, 9g of euphorbia kansui, 10g of asarum, 10g of ephedra, 20g of dried ginger, 10g of schisandra chinensis, 5g of cinnamon, 6g of fennel, 3g of bulbus fritilariae, 16g of honeysuckle, 14g of fructus forsythiae, 20g of liquorice, 5g of schizonepeta spike, 21g of burdock, 22g of lophatherum gracile, 21g of pinellia ternate, 10g of agilawood, 23g of almond, 30g of radix stemonae, 31g of flos daturae, 12g of borneol, 32g of mint and 25g of.

The plaster provided by the invention is prepared by coating 2g of plaster on non-woven fabric, heating until the plaster is scalded, then pasting the plaster on the navel or the Shanzhong acupoint of a patient, changing the dressing once in the morning and evening, and carrying out grouping investigation on the patient, wherein each group contains 20 people, and the result is shown in attached table 1.

Attached table 1

In the attached table 1, the initial cold symptoms of each group are common cold symptoms such as nasal obstruction, rhinorrhea, cough and the like, and the symptoms disappear after the cold symptoms are cured, so that the plaster can play a good role in treating the people of different ages according to the attached table 1.

Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments or portions thereof without departing from the spirit and scope of the invention.

Claims

1. A plaster is characterized by being prepared from the following raw materials in parts by weight, 18-23 parts of white mustard seed, 18-23 parts of corydalis tuber, 1-23 parts of centipeda minima, 8-12 parts of euphorbia kansui, 8-12 parts of asarum, 8-12 parts of ephedra, 18-23 parts of dried ginger, 8-12 parts of schisandra chinensis, 3-7 parts of cinnamon, 3-7 parts of fennel, 3-7 parts of bulbus fritilariae, 13-17 parts of honeysuckle, 13-17 parts of fructus forsythiae, 18-23 parts of liquorice, 3-7 parts of schizonepeta spike, 18-23 parts of burdock, 18-23 parts of lophatherum gracile, 18-23 parts of pinellia ternate, 8-12 parts of agilawood, 20-25 parts of almond, 27-33 parts of radix stemonae, 27-33 parts of flos daturae, 8-12 parts of borneol, 27-33 parts of mint and 21-27 parts of stiff silkworm.

2. The plaster of claim 1, which is prepared from the following raw materials, by weight, 19-21 parts of semen brassicae, 20-22 parts of rhizoma corydalis, 10-17 parts of centipeda minima, 9-10 parts of euphorbia kansui, 9-10 parts of asarum, 10-12 parts of ephedra, 20-22 parts of dried ginger, 10-12 parts of schisandra chinensis, 4-6 parts of cinnamon, 5-7 parts of fennel, 3-4 parts of bulbus fritillariae cirrhosae, 15-16 parts of honeysuckle, 14-16 parts of fructus forsythiae, 20-22 parts of liquorice, 4-6 parts of schizonepeta spike, 20-21 parts of burdock, 20-22 parts of lophatherum gracile, 21-23 parts of pinellia ternata, 9-10 parts of agilawood, 23-25 parts of almond, 30-32 parts of radix stemonae, 30-31 parts of datura flower, 10-12 parts of borneol, 30-32 parts of mint, 30-, 24-27 parts of stiff silkworm.

3. The plaster of claim 1, wherein the plaster comprises 20 parts of semen brassicae, 20 parts of rhizoma corydalis, 20 parts of centipeda minima, 10 parts of euphorbia kansui, 10 parts of asarum, 10 parts of ephedra, 20 parts of rhizoma zingiberis, 10 parts of schisandra chinensis, 5 parts of cinnamon, 5 parts of fennel, 5 parts of bulbus fritillariae cirrhosae, 15 parts of honeysuckle, 15 parts of fructus forsythiae, 20 parts of liquorice, 10 parts of schizonepeta spike, 20 parts of burdock, 20 parts of lophatherum gracile, 20 parts of pinellia ternate, 10 parts of agilawood, 22 parts of almond, 30 parts of radix stemonae, 30 parts of flos daturae, 10 parts of borneol, 30 parts of mint and 24 parts of stiff.

4. A process for producing a plaster according to claim 1, which comprises the steps of,

step six, combining the primary filtrate, the secondary filtrate and the tertiary filtrate, and concentrating into paste to obtain paste for later use;

5. A process for producing a patch according to claim 4, wherein the mixing in step one is carried out using a V-type mixer.

6. A process for producing a patch according to claim 4, wherein the ethanol used in the seventh step, the eighth step and the ninth step is medical ethanol having a concentration of 70 to 80%.