CN107831327A - A kind of cellanalyzer sampling device - Google Patents
A kind of cellanalyzer sampling device Download PDFInfo
- Publication number
- CN107831327A CN107831327A CN201711233970.6A CN201711233970A CN107831327A CN 107831327 A CN107831327 A CN 107831327A CN 201711233970 A CN201711233970 A CN 201711233970A CN 107831327 A CN107831327 A CN 107831327A
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- China
- Prior art keywords
- bracket
- movement frame
- sampling device
- cellanalyzer
- guide rail
- Prior art date
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- Pending
Links
- 238000005070 sampling Methods 0.000 title claims abstract description 37
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims abstract description 25
- 238000001514 detection method Methods 0.000 claims abstract description 19
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 15
- 230000003287 optical effect Effects 0.000 claims abstract description 12
- 210000003205 muscle Anatomy 0.000 claims description 6
- 238000012360 testing method Methods 0.000 claims description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
- 238000007689 inspection Methods 0.000 claims description 2
- 229910052742 iron Inorganic materials 0.000 claims description 2
- 238000012423 maintenance Methods 0.000 abstract description 3
- 238000010923 batch production Methods 0.000 abstract description 2
- 239000000463 material Substances 0.000 description 6
- 238000010586 diagram Methods 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 1
- 238000005282 brightening Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1011—Control of the position or alignment of the transfer device
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a kind of cellanalyzer sampling device, including one enters delivery device, a suction sampling device and an optical detection apparatus.Entering delivery device includes a base, a guide rail, and guide rail is fixed on described base, and a movement frame, movement frame is provided with multiple first strong magnets, and described movement frame is arranged on guide rail.Suction sampling device includes a pedestal, and pedestal is arranged on described base, and a kinematic nest, kinematic nest is arranged on movement frame, one bracket, bracket are fixed in kinematic nest, and the second strong magnet is provided with bracket, one micro-control stream chip, micro-control stream chip is used to contain reagent or sample, and is arranged on bracket；The cellanalyzer sampling device of the present invention operates steadily, and reliably, assembling is simple, easily batch production, easy to maintenance.
Description
Technical field
The present invention relates to a kind of medical analytical instrument, more particularly to a kind of cellanalyzer sampling device.
Background technology
In the medical field, sample introduction is the link that must be many that fluid analysis is carried out to reagent or sample.At present, state
Interior hospital and the input mode of many fluid analysis instruments of scientific research institution still using manual sample introduction and are varied, and this is not only needed
Want staff to take much time and wait sample introduction process with energy, be also unfavorable for the management of reagent or the detection of sample mass.
Now, some medical fluid analytical instrument have an automatically or semi-automatically sampling device both at home and abroad, and it is automatic or half from
In dynamic sampling device, the sample introduction motion of micro-fluidic chip is a technical barrier.Micro-fluidic chip is during sample introduction, Ji Yaobao
When card micro-fluidic chip moves in the horizontal direction, automatic accurate test position or playback can be upwardly or downwardly moved to, together
When also to consider coordination with external structure.At present, automatically or semi-automatically sampling device is that micro-fluidic chip is put mostly both at home and abroad
Heavy platform on sample introduction movement frame is put, drives sample introduction movement frame to move by motor or spring, so as to realize that micro-fluidic chip moves,
But this drive micro-fluidic chip motion can only horizontal movement by the kind of drive, it is impossible to be moved to optimum detection position, shadow
Ring the degree of accuracy to the reagent in micro-fluidic chip or sample detection and analysis.
The content of the invention
The present invention is main to provide a kind of cellanalyzer automatic sampling apparatus, can cause during sample introduction, micro-fluidic core
Piece is accurately moved to optimum detection position.
A kind of cellanalyzer sampling device, including one enter delivery device, described enters delivery device, and it includes：One
Base；One guide rail, guide rail are fixed on described base；One movement frame, described movement frame are provided with multiple first strong magnets,
And described movement frame is arranged on the guide rail；One suction sampling device, it includes：One pedestal, described pedestal are arranged at institute
On the base stated；One kinematic nest, described kinematic nest are arranged on movement frame；One bracket, described bracket are fixed on kinematic nest
On, the second strong magnet is provided with the bracket；One micro-control stream chip, described micro-control stream chip are used to contain reagent or sample
Product, and be arranged on bracket；One optical detection apparatus；The movement frame can be along the guide rail horizontal movement on the base, and institute
The second strong magnet stated on multiple first strong magnets and bracket on movement frame produces mutual attractive force and repulsive force, so as to drive
Micro-control stream chip on described bracket moves up and down, and controls the reagent on micro-control stream chip or sample to be moved to described optics
Detection means observation position.
Cellanalyzer sampling device also includes a stopping means, and the stopping means is sensing that movement frame closing
During position when, trigger detection of the optical detection apparatus to the micro-control stream chip.
Neck is provided with movement frame, the first strong magnet is fixed on the movement frame by the neck, and described first
Strong magnet includes strong magnet A, strong magnet E, strong magnet F.
It is described enter delivery device also include a damper, the damper is provided with a gear, set on the movement frame
There are rack and guide groove, the movement frame carries out cooperating by the gear on the rack and the damper, so that fortune
Dynamic seat is moved by the guide groove.
Counterbore and muscle are provided with the base, the guide rail is fixed on base by the counterbore and muscle.
It is described enter delivery device also include a stage clip, the stage clip is assemblied on the guide rail.
It is described enter delivery device also include a guide rail pressure rack, the guide rail pressure rack is arranged on base.
The second strong magnet on the bracket is strong magnet D.
Locating dowel is provided with the pedestal, so that bracket is positioned on pedestal by the locating dowel, on the pedestal
Guide groove is provided with, so that bracket is moved to test position by the guide groove.
Positioning hole is provided with the top of the bracket, so that bracket is fixed on pedestal by the positioning hole, it is described
Heavy platform is provided with the top of bracket, so that micro-fluidic chip is fixed on bracket by the heavy platform, is set on the bracket
Neck is equipped with, so that the second strong magnet D is fixed on bracket by the neck.
Cellanalyzer sampling device of the present invention, reagent or sample can not only realize that automatic water keeps flat the shifting in direction
It is dynamic, moreover it is possible to be realized and moved up and down by the attraction and repulsive force of magnet, can accurately be moved to optimum detection position.The present invention's
Cellanalyzer sampling device main body, including movement frame, base, guide rail pressure rack, pedestal, kinematic nest, bracket use MPPO materials
Material is made, and because material is hardly influenceed by temperature, humidity, analyzer sampling device is unlikely to deform in use, energy
Effectively reduce to optical detection and enter the influence of export.The present invention cellanalyzer sampling device operate steadily, reliably, group
Dress is simple, easily produces in batches, be easy to maintenance.
Brief description of the drawings
Fig. 1 is the overall structure diagram of the present invention；
Fig. 2 is the part decomposition texture schematic diagram of the present invention.
Fig. 3 is the pedestal schematic diagram of the present invention.
Fig. 4 is the bracket schematic diagram of the present invention.
Embodiment
The present invention is described in further details below with reference to Figure of description and specific embodiment.
As shown in figure 1, a kind of cellanalyzer sampling device, including enter delivery device 1, suction sampling device 2, optics inspection
Survey device 3, stopping means 4.
Fig. 2 is refer to, Fig. 2 is to carry out being developed in details for parts to Fig. 1 cellanalyzer sampling device, enters export
Device 1 includes a base 12, a guide rail 13, a movement frame 11, and guide rail 13 is fixed on base 12, and movement frame 11 is provided with multiple
First strong magnet 100, and movement frame 11 is arranged on guide rail 13.
Suction sampling device, it includes a pedestal 21, and a kinematic nest 22, a bracket 23, a micro-control stream chip 24, pedestal 21 is set
It is placed on described base 12, kinematic nest 22 is arranged on movement frame 11, and bracket 23 is fixed in kinematic nest 22, is set on bracket 23
It is equipped with the second strong magnet 200；Micro-control stream chip 24 is used to contain reagent or sample, and is arranged on bracket 23；
Optical detection apparatus is for observing reagent or sample in the micro-control stream chip 24 on bracket 23.
Movement frame 11 can be along the side-to-side movement of guide rail 13 on base 12, and multiple first strong magnets 100 on movement frame 11
Mutual attractive force and repulsive force are produced with the second strong magnet 200 on bracket 23, so as to drive the micro-control stream chip on bracket 23
24 move up and down, so that the reagent or sample on micro-control stream chip 24 are moved to the observation of described optical detection apparatus 3
Position.
Further, entering delivery device 1 includes movement frame 11, base 12, guide rail 13, in addition to stage clip 14, guide rail pressure
Frame 15, damper 16, strong magnet A 25, strong magnet B 26, strong magnet C 27, strong magnet D 17, strong magnet E 18, strong magnet F
19.It is arranged on movement frame 11 on guide rail 13, neck 111 is provided with the movement frame 11, so that strong magnet A 25, strong magnet
E 18, strong magnet F 19 are fixed on movement frame 11 by neck 111, and rack 112 is provided with movement frame 11, so that damper
16 are operated by the rack 112, and guide groove 113 is provided with movement frame 11, so that kinematic nest 22 passes through guide groove 113
Carry out horizontal movement.
Counterbore 121 and muscle 122 are provided with base 12, so that guide rail 13 is fixed on base 12 by counterbore 121 and muscle 122
On, neck 123 is provided with base 12, so that strong magnet B 26 and strong magnet C 27 is fixed on base by the neck 123
On 12.Guide rail 13 is arranged on base 12, and above-mentioned stage clip 14 is arranged on guide rail 13, and guide rail pressure rack 15 is arranged on base 12,
Gear 161 is provided with above-mentioned damper 16, so that movement frame 11 passes through the stable movement of gear 161.
Suction sampling device 2 includes pedestal 21, kinematic nest 22, bracket 23, strong magnet D 17, strong magnet E 18, strong magnet F
19th, micro-control stream chip 24.Said base 21 is arranged on base 12, locating dowel 211 is provided with the pedestal 21, so that bracket
23 are positioned on pedestal 21 by the locating dowel 211, and guide groove 212 is provided with the pedestal 21, so that bracket 23 passes through
The guide groove 212 is moved to test position 213.
Fig. 3 and Fig. 4 are please also refer to, kinematic nest 22 is arranged on movement frame 11, and heavy platform 221 is set in kinematic nest 22, with
Bracket 23 is set to be fixed on by the heavy platform 221 in kinematic nest 22.Positioning hole 231 is provided with the top of above-mentioned bracket 23, with
Bracket is fixed on by the positioning hole (231) on pedestal 21, heavy platform 232 is provided with the top of the bracket 23, so that
Micro-fluidic chip 24 is fixed on bracket 23 by the heavy platform 232, neck 233 is provided with the bracket 23, so that by force
Magnet D 17 is fixed on bracket 23 by the neck 233, passes through attraction with the strong magnet on motion bracket so as to realize
Realize and move up and down with repulsive force.
Micro-fluidic chip 24 is used to contain reagent or sample, is arranged on the bracket 23, optical detection apparatus 3 is arranged at
On pedestal 21, fixed by connector, such as screw.Stopping means 4 is arranged in guide rail pressure rack 15, and movement frame 11 is provided with hand
114, when horizontal positioned are drawn, is promoted or pull open when pulling 114, the micro-control stream chip 24 on the bracket 23 can be with the water of movement frame 11
Flat motion, meanwhile, the strong magnet F 19 of strong magnet E 18 that the strong magnet D 17 that bracket 23 is equipped with is equipped with movement frame 11 respectively are produced
Raw mutual attractive force and repulsive force, so as to drive bracket 23) on micro-control stream chip 24 move up and down, be easy to observe.
Movement frame 11 gently one is pushed away by manual, can be closed automatically, described spacing in 11 automatic closing process of movement frame
Device 4 can sense that the stopping means 4 can be to the number of delivering letters, and the meeting of optical detection apparatus 3 is to being carried on the micro-fluidic core
Reagent or sample in piece 24 are detected, above-mentioned movement frame 11 by by hand be completely pulled out, acted on without external force, noiseless feelings
Under condition, open mode may be at.
Bracket 23 can take out, and can wipe, and micro-fluidic chip 24 can take out, and be disposable product, to reduce temperature
With influence of the humidity to plastic parts, reduce the micro- change of plastic parts size and the motion of delivery device 1 is detected and entered to optical detection apparatus 3
Influence, movement frame 11, base 12, guide rail pressure rack 15, pedestal 21, kinematic nest 22, bracket 23 can be made of MPPO materials, can be with
It can be its similar material.
In order to reduce the influence to entering the motion of delivery device 1, above-mentioned guide rail 13 uses material to take intensity to be nonmagnetic, bent
Greatly, the stainless steel 303 of surface-brightening.
Entering the structure of delivery device 1 to simplify, above-mentioned guide rail 13 uses solid small pole, and spring uses compression spring 14,
In order to enter the stable movement of delivery device 1, it is above-mentioned enter delivery device 1 be equipped with damper 16.
In order to simplify the structure of suction sampling device 2, above-mentioned bracket 23 is using strong magnetic strength magnet D 17, strong magnet E 18, Qiang Ci
Iron F 19) realize up and down motion.
The cellanalyzer sampling device of the present invention, reagent or sample can move up and down, and can accurately be moved to optimal
Test position.And the cellanalyzer sampling device invented operates steadily, reliably, assembling is simple, easily batch production, maintenance
It is convenient.
The above is only the preferred embodiment of the present invention, protection scope of the present invention degree is not only limited to above-described embodiment,
All technical schemes belonged under thinking of the present invention belong to protection scope of the present invention.It should be pointed out that for the art
For those of ordinary skill, not as some improvements and modifications under the premise of departing from the present invention, protection model of the invention is treated as
Enclose.
Claims (10)
- A kind of 1. cellanalyzer sampling device, it is characterised in that including：One enters delivery device, and described enters delivery device, and it includes：One base；One guide rail, guide rail are fixed on described base；One movement frame, described movement frame is provided with multiple first strong magnets, and described movement frame is arranged on the guide rail；One suction sampling device, it includes：One pedestal, described pedestal are arranged on described base；One kinematic nest, described kinematic nest are arranged on movement frame；One bracket, described bracket are fixed in kinematic nest, and the second strong magnet is provided with the bracket；One micro-control stream chip, described micro-control stream chip is used to contain reagent or sample, and is arranged on bracket；One optical detection apparatus；The movement frame can be along the guide rail horizontal movement on the base, and multiple first strong magnets and support on the movement frame The second strong magnet on frame produces mutual attractive force and repulsive force, so as to drive the micro-control stream chip on described bracket to transport up and down It is dynamic, control the reagent on micro-control stream chip or sample to be moved to described optical detection apparatus observation position.
- 2. cellanalyzer sampling device according to claim 1, it is characterised in that also including a stopping means, institute Stopping means is stated when sensing movement frame to precalculated position, triggers inspection of the optical detection apparatus to the micro-control stream chip Survey.
- 3. cellanalyzer sampling device according to claim 2, it is characterised in that be provided with card on the movement frame Groove, first strong magnet are fixed on the movement frame by the neck, and first strong magnet includes strong magnet A, strong Magnet E, strong magnet F.
- 4. cellanalyzer sampling device according to claim 3, it is characterised in that it is described enter delivery device also include One damper, the damper are provided with a gear, are provided with rack and guide groove on the movement frame, the movement frame passes through Gear on the rack and the damper carries out cooperating, so that kinematic nest carries out horizontal fortune by the guide groove It is dynamic.
- 5. cellanalyzer sampling device according to claim 4, it is characterised in that be provided with counterbore on the base And muscle, the guide rail is fixed on base by the counterbore and muscle.
- 6. cellanalyzer sampling device according to claim 5, it is characterised in that entering delivery device also includes a pressure Spring, the stage clip are assemblied on the guide rail.
- 7. cellanalyzer sampling device according to claim 6, it is characterised in that it is described enter delivery device also include One guide rail pressure rack, the guide rail pressure rack are arranged on base.
- 8. cellanalyzer sampling device according to claim 7, it is characterised in that the last the second magnetic on the bracket Iron is strong magnet D.
- 9. cellanalyzer sampling device according to claim 8, it is characterised in that positioning is provided with the pedestal Post, so that bracket is positioned on pedestal by the locating dowel, guide groove is provided with the pedestal so that bracket pass through it is described Guide groove is moved to test position.
- 10. cellanalyzer sampling device according to claim 9, it is characterised in that set on the top of the bracket Positioning hole is equipped with, so that bracket is fixed on pedestal by the positioning hole, heavy platform is provided with the top of the bracket, so that Micro-fluidic chip is fixed on bracket by the heavy platform, and neck is provided with the bracket, so that the second strong magnet D passes through The neck is fixed on bracket.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711233970.6A CN107831327A (en) | 2017-11-30 | 2017-11-30 | A kind of cellanalyzer sampling device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711233970.6A CN107831327A (en) | 2017-11-30 | 2017-11-30 | A kind of cellanalyzer sampling device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107831327A true CN107831327A (en) | 2018-03-23 |
Family
ID=61647128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711233970.6A Pending CN107831327A (en) | 2017-11-30 | 2017-11-30 | A kind of cellanalyzer sampling device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107831327A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021143953A1 (en) * | 2020-01-16 | 2021-07-22 | 利多(香港)有限公司 | Object stage and transfer platform for biological sample analyzer, and biological sample analyzer |
| CN114252385A (en) * | 2021-12-16 | 2022-03-29 | 江苏康尚生物医疗科技有限公司 | Portable leukocyte subclass detection device and method |
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| US20020110902A1 (en) * | 2001-01-26 | 2002-08-15 | Prosser Simon J. | Robotic autosampler for automated electrospray from a microfluidic chip |
| JP2008064518A (en) * | 2006-09-06 | 2008-03-21 | Hitachi High-Technologies Corp | Sample analyzer and channel clogging determination method |
| CN201508314U (en) * | 2009-09-17 | 2010-06-16 | 开物科技股份有限公司 | Reagent analysis meter for rapidly detecting isolated light interference. |
| WO2013041007A1 (en) * | 2011-09-21 | 2013-03-28 | 艾康生物技术(杭州)有限公司 | Biochemical analyzer and tester |
| CN203925955U (en) * | 2014-07-10 | 2014-11-05 | 大连海事大学 | A kind of electromagnetism Micropump based on micro-fluidic chip |
| CN203918851U (en) * | 2014-06-27 | 2014-11-05 | 珠海科域生物工程有限公司 | A kind of magnetic force fast-positioning device |
| CN104849477A (en) * | 2015-01-23 | 2015-08-19 | 江苏大学 | Portable microfluidic detection apparatus and method for organophosphorus pesticide |
| CN106706943A (en) * | 2015-07-27 | 2017-05-24 | 博奥赛斯（天津）生物科技有限公司 | Sample introduction detecting mechanism of fluorescent immunity analyzer |
| CN106771302A (en) * | 2016-12-19 | 2017-05-31 | 宁波美康盛德生物科技有限公司 | Biochemical Analyzer sample feeding propulsive mechanism |
| CN207472902U (en) * | 2017-11-30 | 2018-06-08 | 江苏康尚生物医疗科技有限公司 | A kind of cellanalyzer sampling device |
-
2017
- 2017-11-30 CN CN201711233970.6A patent/CN107831327A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020110902A1 (en) * | 2001-01-26 | 2002-08-15 | Prosser Simon J. | Robotic autosampler for automated electrospray from a microfluidic chip |
| JP2008064518A (en) * | 2006-09-06 | 2008-03-21 | Hitachi High-Technologies Corp | Sample analyzer and channel clogging determination method |
| CN201508314U (en) * | 2009-09-17 | 2010-06-16 | 开物科技股份有限公司 | Reagent analysis meter for rapidly detecting isolated light interference. |
| WO2013041007A1 (en) * | 2011-09-21 | 2013-03-28 | 艾康生物技术(杭州)有限公司 | Biochemical analyzer and tester |
| CN203918851U (en) * | 2014-06-27 | 2014-11-05 | 珠海科域生物工程有限公司 | A kind of magnetic force fast-positioning device |
| CN203925955U (en) * | 2014-07-10 | 2014-11-05 | 大连海事大学 | A kind of electromagnetism Micropump based on micro-fluidic chip |
| CN104849477A (en) * | 2015-01-23 | 2015-08-19 | 江苏大学 | Portable microfluidic detection apparatus and method for organophosphorus pesticide |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2021143953A1 (en) * | 2020-01-16 | 2021-07-22 | 利多(香港)有限公司 | Object stage and transfer platform for biological sample analyzer, and biological sample analyzer |
| CN114252385A (en) * | 2021-12-16 | 2022-03-29 | 江苏康尚生物医疗科技有限公司 | Portable leukocyte subclass detection device and method |
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