CN107801999A - 一种具有血管舒张作用的杜仲叶***片 - Google Patents
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Abstract
本发明为一种具有血管舒张作用的杜仲叶***片。以杜仲叶为原料，经清洗、室温阴干，使用粉碎机粉碎为粗粉，加入蒸馏水提取2次，合并两次提取液得到杜仲叶水提取物，杜仲叶水提取液经喷雾干燥制得杜仲叶水溶性粉体，杜仲叶水溶性粉体与木糖醇、硬脂酸镁等辅料按比例混合，用压片机压片制得杜仲叶***片。本发明得到的***片具有血管舒张作用，尤其适合高血压伴糖尿病人群，便于携带、食用方便，制备过程简单易行、绿色环保，可作为日常降血压保健食品。
Description
所属技术领域
本发明涉及一种***片，特别涉及一种具有血管舒张作用的无毒副作用的***片的发明与制备。
背景技术
杜仲，是我国特有树种，是杜仲科杜仲属仅存的孑遗植物，现己作为稀有植物被列入《中国植物红皮书－稀有濒危植物》。杜仲皮是名贵滋补药材，在《神农本草经》中被列为上品。杜仲叶在卫计委公布的药食同源原料目录中为可用于保健食品的中药，其热水冲泡直接服用对高血压的防治有很好的疗效，杜仲叶中含有多种天然成分，主要包括木脂素类、环烯醚萜类、黄酮类化合物，此外还含有苯丙素类、多糖类、杜仲胶、萜类、多种氨基酸、维生素、矿物质等其他具有生物学活性的天然成分。
杜仲叶提取物具有血管舒张作用已有文献报道。王梦华等在离体血管条水平上，探讨了杜仲叶提取物舒张血管的作用机制，发现杜仲叶提取物通过促进内皮细胞释放NO和直接激活β受体产生舒张血管效应；另有实验证明杜仲叶水提物的舒张血管作用是内皮依赖性的，通过内皮衍生超极化因子起作用。鉴于杜仲叶具有血管舒张作用，人们对其开展了不断深入的研究，其在临床应用上开发的前景也非常不错，市面上的产品形式主要为杜仲降压茶和杜仲降压片。杜仲降压茶为将杜仲叶直接做成茶叶形式，经热水冲泡后饮用，存在携带和服用不方便、活性成分溶出慢等缺点；杜仲降压片为治疗高血压的临床用药物，为杜仲皮(炒)与其它中药组成的复方片剂，适用人群范围窄。本品以可用于保健食品的中药杜仲叶为原料，经提取、喷粉、压片等制备工艺得到的杜仲叶***片便于携带、食用方便，因将配方中改善口味的糖粉用木糖醇替代，尤其适合高血压伴糖尿病人群，整个制备过程简单易行、绿色环保，可作为日常降血压保健食品。
发明内容
本发明的目的在于制备一种便于携带、食用方便、适合高血压伴糖尿病人群的具有血管舒张作用的杜仲叶***片。
为了达到上述目的，本发明采用的技术方案是：以杜仲叶为原料，经清洗、阴干、粉碎后进行提取，得到杜仲叶提取液，将杜仲叶提取液采用喷雾干燥方法制备成杜仲叶水溶性粉体，杜仲叶水溶性粉体按比例与木糖醇、硬脂酸镁等辅料混合压片制得杜仲叶***片。
本发明的优点：
1、制备工艺简单，无有毒溶剂，可进行工业化生产。
2、所用杜仲叶为树龄为25年以上杜仲树的叶子，保证活性成分含量。
3、杜仲叶水提取物采用喷雾干燥方法制备得到杜仲叶水溶性粉体，此粉体分散性好、溶解性好，易于吸收。
4、配方中改善口味成分为木糖醇，适合糖尿病人群的服用。
5、***片形式便于携带和服用。
具体实施方案：
下面对本发明的实施方案作进一步详细描述：
将树龄在25年以上的杜仲树的杜仲叶清洗、室温阴干，使用粉碎机粉碎为粗粉，加入其质量10～20倍的蒸馏水提取，超声提取时间为50～70分钟，提取温度为80～100℃，提取2次，合并两次提取液得到杜仲叶水提取物。杜仲叶水提取液经喷雾干燥制得杜仲叶水溶性粉体，喷雾干燥进风温度100℃～140℃，进料速率250mL～350mL/h，进风量60-80m3/min。将杜仲叶水溶性粉体与木糖醇、硬脂酸镁等辅料按比例混合，以重量份计，单位为克，分别称取杜仲叶水溶性粉体9～15份，甘露醇15～20份，木糖醇15～20份，薄荷脑0.5～1.5份，硬脂酸镁0.5～1.5份。将上述除薄荷脑和硬脂酸镁以外的各物质混合均匀，喷入薄荷脑乙醇溶液，自由吸附后于30-40℃烘箱内将乙醇烘干，然后将硬脂酸镁(要求细度达到100目以上)按等量递加法加入上述混合物中混合均匀，用压片机压片，每片重1.5g～2.5g。
实施例1
取树龄为25年的杜仲树的叶子，用水清洗后室温阴干，使用粉碎机粉碎为粗粉，取杜仲叶粗粉100g加入1.5L蒸馏水，超声加热提取，提取时间为60min，提取温度为85℃，过滤，滤渣加入1.0L蒸馏水按以上条件再提取一次，过滤后合并两次滤液，得到杜仲叶水提取物2.36L，将杜仲叶水提取液经喷雾干燥，喷雾干燥进风温度120℃，进料速率300mL/h，进风量65m3/min，得到杜仲叶水溶性粉体9.5g。分别称取杜仲叶水溶性粉体5.0g，甘露醇9.5g，木糖醇9.5g，混合均匀；称取薄荷脑0.48g，溶于3mL食用乙醇中，均匀喷入上述粉末中，自由吸附后于35℃烘箱内将乙醇烘干；称取100目硬脂酸镁0.52g按等量递加法与上述粉末混合均匀后用压片机压片，每片重2g。
实施例2
取树龄为25年的杜仲树的叶子，用水清洗后室温阴干，使用粉碎机粉碎为粗粉，取杜仲叶粗粉100g加入1.0L蒸馏水，超声加热提取，提取时间为60min，提取温度为85℃，过滤，滤渣加入1.5L蒸馏水按以上条件再提取一次，过滤后合并两次滤液，得到杜仲叶水提取物2.34L，将杜仲叶水提取液经喷雾干燥，喷雾干燥进风温度130℃，进料速率330mL/h，进风量75m3/min，得到杜仲叶水溶性粉体9.1g。分别称取杜仲叶水溶性粉体5.5g，甘露醇9.0g，木糖醇9.5g，混合均匀；称取薄荷脑0.55g，溶于3mL食用乙醇中，均匀喷入上述粉末中，自由吸附后于35℃烘箱内将乙醇烘干；称取100目硬脂酸镁0.45g按等量递加法与上述粉末混合均匀后用压片机压片，每片重2g。
实施例3
取树龄为25年的杜仲树的叶子，用水清洗后室温阴干，使用粉碎机粉碎为粗粉，取杜仲叶粗粉100g加入1.2L蒸馏水，超声加热提取，提取时间为60min，提取温度为85℃，过滤，滤渣加入1.3L蒸馏水按以上条件再提取一次，过滤后合并两次滤液，得到杜仲叶水提取物2.34L，将杜仲叶水提取液经喷雾干燥，喷雾干燥进风温度140℃，进料速率350mL/h，进风量80m3/min，得到杜仲叶水溶性粉体9.0g。分别称取杜仲叶水溶性粉体6.0g，甘露醇9.0g，木糖醇9.0g，混合均匀；称取薄荷脑0.5g，溶于3mL食用乙醇中，均匀喷入上述粉末中，自由吸附后于35℃烘箱内将乙醇烘干；称取100目硬脂酸镁0.5g按等量递加法与上述粉末混合均匀后用压片机压片，每片重2g。
Claims (5)
1.一种具有血管舒张作用的杜仲叶***片，其特征在于：以杜仲叶为原料，经清洗、阴干、粉碎后进行提取，得到杜仲叶提取液，将杜仲叶提取液采用喷雾干燥方法制备成杜仲叶水溶性粉体，杜仲叶水溶性粉体按比例与木糖醇、硬脂酸镁等辅料混合压片制得杜仲叶***片。本发明得到的***片具有血管舒张作用，尤其适合高血压伴糖尿病人群，便于携带、食用方便，制备过程简单易行、绿色环保，可作为日常降血压保健食品。
2.按照权利要求1所述的杜仲叶，其特征在于：杜仲叶为树龄在25年以上的杜仲树的叶子。
3.按照权利要求1所述的杜仲叶提取液，其特征在于：杜仲叶用热水提取得到的溶液，提取方法为超声提取，料液比为10:1～20:1，提取时间为50～70分钟，提取温度为80～100℃，提取次数为2次。
4.按照权利要求1所述的杜仲叶水溶性粉体，其特征在于：杜仲叶提取液经喷雾干燥制得的粉末，其特征在于：进风温度100℃～140℃，进料速率250ml～350ml/h，进风量60-80m3/min。
5.按照权利要求1所述的杜仲叶水溶性粉体按比例与木糖醇、硬脂酸镁等辅料混合压片制得杜仲叶***片，其特征在于：以重量份计，杜仲叶水溶性粉体9～15份，甘露醇15～20份，木糖醇15～20份，薄荷脑0.5～1.5份，硬脂酸镁0.5～1.5份。
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| CN109349642A (zh) * | 2018-12-26 | 2019-02-19 | 陕西天承生物科技股份有限公司 | 一种提高人体免疫力的杜仲叶复方含片及其制备方法 |
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| CN109730304A (zh) * | 2018-12-26 | 2019-05-10 | 陕西学前师范学院 | 一种杜仲叶安神复方含片及其制备方法 |
| CN109757722A (zh) * | 2018-12-26 | 2019-05-17 | 陕西学前师范学院 | 一种杜仲叶明目复方含片及其制备方法 |
| CN112438395A (zh) * | 2019-09-05 | 2021-03-05 | 汪建民 | 一种杜仲肽泡腾含化片 |
| CN112245464A (zh) * | 2020-10-13 | 2021-01-22 | 天津益倍元天然产物技术有限公司 | 一种防治高血压肾损伤的杜仲叶提取物制备方法及应用 |
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