CN107787977A - A kind of hygienic biocide composition containing Nylar and its application - Google Patents
A kind of hygienic biocide composition containing Nylar and its application Download PDFInfo
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- CN107787977A CN107787977A CN201710748409.5A CN201710748409A CN107787977A CN 107787977 A CN107787977 A CN 107787977A CN 201710748409 A CN201710748409 A CN 201710748409A CN 107787977 A CN107787977 A CN 107787977A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/002—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing a foodstuff as carrier or diluent, i.e. baits
- A01N25/006—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing a foodstuff as carrier or diluent, i.e. baits insecticidal
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N51/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring
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Abstract
The present invention relates to a kind of hygienic biocide composition containing Nylar.The composition contains active component A and B, and the weight ratio of the two is 1:99~99:1；The active component A is Nylar；One or more of the active component B in ethiprole, ethiprole, Rynaxypyr, fluorobenzene insect amide, orthene, chlopyrifos, arprocarb, imidacloprid, MTI-446, clothianidin, indoxacarb, AVM, emamectin-benzoate or ivermectin；The composition contains selected from poly-lactic acid ester, polyhydroxyalkanoate or beta cyclodextrin as occlusion vehicle, and the weight ratio of the active component A and B total amount and occlusion vehicle is 1:3‑1:5；The hygienic biocide composition is glue bait or particle bait formulation.After the active component adds glue bait, particle bait formulation, liquid bait formulation or concentration bait formulation in the form of particular polymers microballoon, the palatability of blattaria is greatly increased, so as to improve toxic effect.
Description
Technical field
The present invention relates to a kind of hygienic insecticide field, a kind of particularly hygienic biocide composition containing Nylar
And its application.
Background technology
Nylar, also known as pyriproxyfen, chemical name：4- phenoxy phenyls (RS) -2- (2- pyridine radicals oxygen) propyl ether, is WHO
Recommend one of insect growth regulator, IGR for preventing and treating sanitary insect pest, have tag, stomach toxicity and strong ovicidal action, efficiently,
Dosage is few, lasting period length.Experiment display, Nylar have unique killing effect to the nymph of Groton bug and ovum.
Prior art discloses be related to Nylar and ethiprole, imidacloprid, MTI-446, clothianidin, indoxacarb, AVM, first
The compounding of amino abamectin benzoate etc., all it is to be applied to agricultural pests and agriculture formulation, there is no specifically for health evil
The Patents of worm blattaria, and blattaria glue bait or particle bait formulation are different from conventional pesticide formulation, it is for active ingredient to blattaria
Palatability have very high requirement；After adding blattaria glue bait or particle bait formulation due to Nylar, the feeding to blattaria has certain
Inhibitory action, so as to reduce the killing effect of blattaria glue bait or particle bait formulation, this is also that domestic there is presently no by Nylar
The reason for in blattaria glue bait or particle bait formulation.
Rich experiences of the applicant based on oneself in sanitary insect pest field, by special auxiliary agent and technique, by Nylar
The bait formulation suitable for being used in health is prepared into the complex composition of ethiprole, chlopyrifos etc., which solves current Nylar
The problem of palatability is bad；The complex composition of the present invention, the good natural or natural component synthesis of preferred pair blattaria palatability
Embedding medium is embedded to active ingredient in the form of polymer microballoon, has efficient, low toxicity, the lasting period is long, killing rate is high
Feature, be especially suitable for the thorough preventing and treating of blattaria, especially from preferably compound with preparation method after, the quick killing to blattaria
Effect and thorough go out control effect, compared to the existing raising killed roach formulation, there is by a relatively large margin.
Goal of the invention
An object of the present invention is to provide a kind of good disinsection effect, and the low stimulation of low toxicity, easy to use, killing rate is high,
And can delay sanitary insect pest develop immunity to drugs and meanwhile for sanitary insect pest have high palatability, contain Nylar and specific
Kill Pesticidal combination of roach composition and preparation method thereof.
To realize the purpose of the present invention, technical scheme is as follows：
A kind of hygienic biocide composition containing Nylar, it is characterised in that the composition contains active component A and B, the two
Weight ratio be 1:99~99:1；
The active component A is Nylar；
The active component B be selected from ethiprole, ethiprole, Rynaxypyr, fluorobenzene insect amide, orthene, chlopyrifos,
Arprocarb, imidacloprid, MTI-446, clothianidin, indoxacarb, AVM, emamectin-benzoate or ivermectin
In one or more；
The composition contains selected from poly-lactic acid ester, polyhydroxyalkanoate or beta cyclodextrin as occlusion vehicle, the activearm
It is 1 to divide A and B total amount and the weight ratio of occlusion vehicle:3-1:5；
The hygienic biocide composition is bait formulation, such as glue bait, particle bait formulation, liquid bait formulation or concentration bait formulation.
Preferably, the active component B is ethiprole, Rynaxypyr, MTI-446, indoxacarb or emamectin benzoate benzene
Formates；It is highly preferred that the active component B is ethiprole and emamectin-benzoate.
Preferably, in the hygienic biocide composition, the weight ratio of Nylar and B component is 1:50~50:1；It is highly preferred that two
The weight ratio of person is 1:20~20:1；Most preferably, the weight ratio of the two is 1:5~5:1.
Preferably, the occlusion vehicle is polyhydroxyalkanoate.
Preferably, the weight ratio of active component A and B total amount and occlusion vehicle is 1:4.
Further, the present invention provides a kind of method for preparing above-mentioned hygienic biocide composition, it is characterised in that methods described bag
Include following steps：
Step 1：The preparation of polymer microballoon：Active component A, B, occlusion vehicle are dissolved in by weight the third of 3-5 times in proportion
In ketone, dichloroethanes or water, polymer microballoon is made after drying in subsequent spray；
Step 2：According to a conventional method with glue bait, particle bait formulation, liquid bait formulation or the substrate for concentrating bait formulation, then add
The polymer microballoon of step 1, final glue bait or particle bait formulation is made.
Further, the present invention provides the purposes that above-mentioned hygienic biocide composition is used to prevent and treat sanitary insect pest, the sanitary insect pest
For blattaria.
Explained on principle：Prior art is typically directly to mix active component and the substrate with glue bait or particle bait formulation
Close, but for this kind of active component poor for sanitary insect pest palatability of Nylar and do not apply to, applicant passes through up to number
Year research find, when before being mixed with base material, first by the hygienic biocide composition containing Nylar and specific embedding
Carrier and with specific ratio mix, one side Nylar and the compatibility of B activity component are more preferable, another aspect, can pass through
The high compatibility of embedded material and Nylar, the agreeable to the taste of Nylar particularly allowed to covering for Nylar smell and bitter taste
Property greatly improves.
Compared with prior art, beneficial effects of the present invention are：
（1）Compared with single dose, Pesticidal combination of the present invention is respectively provided with very high killing effect to blattaria adult, nymph and ovum
Fruit, long-term thoroughly insect killing effect are very good；
（2）The Nylar after active component B compoundings with having the characteristics of efficiency time is long, killing rate is high.
（3）After the active component adds glue bait or particle bait formulation in the form of particular polymers microballoon, to the palatability of blattaria
It is greatly increased, so as to improve toxic effect.
（4）Composition is made up of the complementary active ingredient of insecticidal mechanism, action site increase, is advantageous to overcome and delay the resistance to the action of a drug
Generation.
（5）A new complex composition is added for domestic hygienic biocide field, drug effect is notable, can widely be promoted
Using.
Embodiment
The present invention is further described with reference to specific embodiment, but does not limit the invention to these tools
Body embodiment.One skilled in the art would recognize that present invention encompasses may include in Claims scope
All alternatives, improvement project and equivalents.
First, method for preparing polymer micro：
A, poly-lactic acid ester method for preparing microsphere：
Nylar 2.5g, ethiprole 0.5g, poly-lactic acid ester 9.0g are completely dissolved with acetone, solution is made by pressure atomizer
Be atomized into fine droplet and flash evapn wherein solvent and solidify to obtain 25% Nylar ethiprole polymer microballoon.
B, polyhydroxyalkanoate method for preparing microsphere：
Nylar 1.0g, chlopyrifos 2.0g, polyhydroxyalkanoate 12g are completely dissolved with dichloroethanes, pass through pressure type mist
Change device make solution atomization into fine droplet and flash evapn wherein solvent and solidify 20% Nylar chlopyrifos polymer is micro-
Ball.
C, beta cyclodextrin method for preparing microsphere：
Nylar 2.0g, emamectin-benzoate 1.0g, beta cyclodextrin 15g is completely molten with 75% aqueous acetone solution
Solution, makes solution atomization into fine droplet and flash evapn wherein solvent to solidify to obtain 16.7% pyrrole third by pressure atomizer
Ether emamectin benzoate polymer microballoon.
2nd, glue bait or particle bait formulation prepare embodiment（Prepare embodiment and prepare polymer microballoon by above-mentioned correlation method）
Involved " % " is weight percentage in following all formulations proportionings.
Example of formulations 1：
20g white granulated sugars, 10g milk powder, 20g glycerine, 1.0g sodium benzoates are completely dissolved with suitable quantity of water, it is fine to add 1.5g ethoxys
Dimension element fully shear gel, 120 DEG C of high-temperature sterilization 30min, adds containing fipronil 0.05g, Nylar when being cooled to 45 DEG C
0.45g, poly-lactic acid ester 2.2g polymer microballoon, high speed shear homogeneous produce 0.5% ethiprole Nylar glue bait.
Example of formulations 2：
20g white granulated sugars, 10g milk powder, 20g glycerine, 1.0g sodium benzoates are completely dissolved with suitable quantity of water, it is fine to add 1.5g ethoxys
Dimension element fully shear gel, 120 DEG C of high-temperature sterilization 30min, adds benzoic acid containing emamectin benzoate when being cooled to 45 DEG C
Salt 0.1g, Nylar 0.5g, polyhydroxyalkanoate 1.8g polymer microballoon, high speed shear homogeneous produce 0.6% emamectin benzoate
Nylar glue bait.
Example of formulations 3：
20g white granulated sugars, 10g milk powder, 20g glycerine, 1.0g sodium benzoates are completely dissolved with suitable quantity of water, it is fine to add 1.5g ethoxys
Dimension element fully shear gel, 120 DEG C of high-temperature sterilization 30min, adds containing chlorantraniliprole 0.5g, pyrrole third when being cooled to 45 DEG C
Ether 0.5g, beta cyclodextrin 4.5g polymer microballoon, high speed shear homogeneous produce 1.0% Rynaxypyr Nylar glue bait.
Example of formulations 4：
20g white granulated sugars, 10g milk powder, 20g glycerine, 1.0g sodium benzoates are completely dissolved with suitable quantity of water, it is fine to add 1.5g ethoxys
Dimension element fully shear gel, 120 DEG C of high-temperature sterilization 30min, adds 0.5g containing indoxacarb, Nylar when being cooled to 45 DEG C
0.5g, beta cyclodextrin 3.0g polymer microballoon, high speed shear homogeneous produce 1.0% indoxacarb Nylar glue bait.
Example of formulations 5：
20g white granulated sugars, 10g milk powder, 20g glycerine, 1.0g sodium benzoates are completely dissolved with suitable quantity of water, it is fine to add 1.5g ethoxys
Dimension element fully shear gel, 120 DEG C of high-temperature sterilization 30min, adds 0.5g containing MTI-446, Nylar when being cooled to 45 DEG C
0.5g, poly-lactic acid ester 3.0g polymer microballoon, high speed shear homogeneous produce 1.0% MTI-446 Nylar glue bait.
Example of formulations 6：
Mixed after white granulated sugar 20g, milk powder 15g, analysis for soybean powder 30g are crushed with sodium benzoate 1.0g, soybean oil 5.0g, appropriate ground rice
Uniformly, 0.5g containing MTI-446, Nylar 0.5g, polyhydroxyalkanoate 3.0g polymer microballoon are then added, is fully mixed,
Then plus water is granulated, and is sieved after 80 DEG C of drying and is produced 1.0% MTI-446 Nylar particle bait formulation.
Example of formulations 7：
In addition to polyhydroxyalkanoate is 4.0g, remaining is the same as example of formulations 6；
Example of formulations 8：
In addition to polyhydroxyalkanoate is 5.0g, remaining is the same as example of formulations 6；
3rd, glue bait or particle bait formulation comparing embodiment（Comparing embodiment adds active ingredient according to a conventional method）
Comparing embodiment 1：
20g white granulated sugars, 10g milk powder, 20g glycerine, 1.0g sodium benzoates are completely dissolved with suitable quantity of water, it is fine to add 1.5g ethoxys
Dimension element fully shear gel, 120 DEG C of high-temperature sterilization 30min, add the ethiprole 0.05g for beating powder and melting when being cooled to 45 DEG C
Nylar 0.45g, high speed shear homogeneous produces 0.5% ethiprole Nylar glue bait of comparing embodiment 1.
Comparing embodiment 2：
20g white granulated sugars, 10g milk powder, 20g glycerine, 1.0g sodium benzoates are completely dissolved with suitable quantity of water, it is fine to add 1.5g ethoxys
Dimension element fully shear gel, 120 DEG C of high-temperature sterilization 30min, add the ethiprole 0.05g for beating powder, at a high speed when being cooled to 45 DEG C
Shearing homogeneous produces 0.05% ethiprole glue bait of comparing embodiment 2.
Comparing embodiment 3：
20g white granulated sugars, 10g milk powder, 20g glycerine, 1.0g sodium benzoates are completely dissolved with suitable quantity of water, it is fine to add 1.5g ethoxys
Dimension element fully shear gel, 120 DEG C of high-temperature sterilization 30min, the Nylar 0.45g of melting is added when being cooled to 45 DEG C, at a high speed
Shearing homogeneous produces 0.45% Nylar glue bait of comparing embodiment 1.
Comparing embodiment 4：
Mixed after white granulated sugar 20g, milk powder 15g, analysis for soybean powder 30g are crushed with sodium benzoate 1.0g, soybean oil 5.0g, appropriate ground rice
Uniformly, the powder 0.5g of original containing MTI-446 is then added, is fully mixed, then plus water is granulated, and is sieved after 80 DEG C of drying and is produced 0.5% furan
Worm amine particle bait formulation.
Comparing embodiment 5：
It is well mixed with sodium benzoate 1.0g, appropriate ground rice after white granulated sugar 20g, milk powder 15g, analysis for soybean powder 30g are crushed, then will
Nylar 0.5g is added after being dissolved with soybean oil 5.0g, is fully mixed, and then plus water is granulated, and is sieved after 80 DEG C of drying and is produced 0.5%
Nylar particle bait formulation.
Comparing embodiment 6：
In addition to occlusion vehicle replaces polyhydroxyalkanoate using hydroxyethyl cellulose, remaining is the same as preparation embodiment 6；
Comparing embodiment 7：
In addition to occlusion vehicle replaces polyhydroxyalkanoate using poly-vinegar acid esters, remaining is the same as preparation embodiment 6；
Comparing embodiment 8：
In addition to polyhydroxyalkanoate is 2.5g, remaining is the same as example of formulations 6；
Comparing embodiment 9：
In addition to polyhydroxyalkanoate is 5.5g, remaining is the same as example of formulations 6；
Application Example 1：Groton bug indoor biological active determination test
With reference to agriculture chemical registration the 7th part of hygienic insecticide indoor pharmacodynamic test and evaluation：The test method of bait formulation, tests this hair
The effect of the Groton bug of going out of bright example of formulations and comparative example.Test worm is sensitive strain, test 24h before fasting can't help
Water, 30 adult male and female half and half, move into 0.7m × 0.7m × 0.7m glass square chest, case inner opposite angle is placed and poison bait to be measured every time
Phase homogenous quantities and the feed 2.0g of packaging（It is accurate to 0.2mg）, water is fed with immersion cotton balls, observes death toll, continuous observation day by day
12d, test at least repeat to average three times.Observation palatability method is to be placed in contrast agents in square chest simultaneously, in experiment
Remaining poison bait and quality of the fodder are weighed during 24h（It is accurate to 0.2mg）, take the average value of three repetitions, measurement result is as follows
（Table -1 and table -2）：
The Groton bug indoor biological active determination test result of table -1：
Palatability determination test result in the Groton bug of table -2 room：
Measurement result shows that Nylar is invalid to Groton bug adult, and compared to ethiprole, the palatability of Nylar glue bait is poor,
And use 0.5% ethiprole Nylar glue bait palatability of polymer microballoon technique preparation and killing rate all best, illustrate this
Invention after particular polymers technique embedding active compound to Groton bug palatability using significantly improving, and killing rate is substantially accelerated, tool
There is more preferable killing effect.
It is worth noting that, the polyhydroxyalkanoate that different amounts are used in embodiment 6,7,8 is prepared, wherein preparing embodiment
7 best results, i.e., when the weight ratio of active component A and B total amount and occlusion vehicle is 1:Best results when 4；In addition, than
Compared with embodiment part, when comparing embodiment 6,7 is specific far below the present invention as embedded material, its effect using other materials
Embedded material, or even in comparing embodiment 8 and 9, when the weight ratio of active component A and B total amount and occlusion vehicle be
1:When outside 3-5, its effect is also much also worse not as good as the killing effect under the specific amount ratio of the present invention, palatability；
Example of formulations 2, example of formulations 3 and the indoor biological active determination test of example of formulations 5 also have as above similar effect
Fruit, it is as a result as follows：
The emamectin benzoate Nylar glue bait indoor biological active determination test result of table -3 0.6%：
Remarks：Common 0.6% emamectin benzoate Nylar glue bait, common 0.1% emamectin benzoate glue bait are that reference prepares embodiment 2 to make
Standby, wherein common 0.6% emamectin benzoate Nylar glue bait, in addition to without occlusion vehicle, remaining is with embodiment 2 is prepared, commonly
0.1% emamectin benzoate glue bait in addition to not comprising occlusion vehicle, not comprising Nylar outside, remaining with prepare embodiment 2.
The Rynaxypyr Nylar glue bait indoor biological active determination test result of table -4 1.0%：
Remarks：Common 1.0% Rynaxypyr Nylar glue bait, common 0.5% Rynaxypyr glue bait are with reference to system
Prepared by standby embodiment 3, wherein common 1.0% Rynaxypyr Nylar glue bait, in addition to without occlusion vehicle, remaining is same
Prepare embodiment 3, common 0.5% Rynaxypyr glue bait in addition to not comprising occlusion vehicle, not comprising Nylar outside, remaining is same
Prepare embodiment 3.
The MTI-446 Nylar particle bait formulation indoor biological active determination test result of table -5 1.0%：
Remarks：Common 1.0% MTI-446 Nylar particle bait formulation, common 0.5% MTI-446 particle bait formulation are real with reference to preparing
Apply example 5 to prepare, wherein common 1.0% MTI-446 Nylar particle bait formulation, in addition to without occlusion vehicle, remaining is real with preparing
Apply example 5, common 0.5% MTI-446 particle bait formulation in addition to not comprising occlusion vehicle, not comprising Nylar outside, remaining is implemented with preparing
Example 5.
Application Example 2：Go out roach effect test at Groton bug scene
Test method：In 12, certain hotel 2 ~ 3 building parlor, each medicament randomly chooses three rooms, according to timing, fixed point observation
Counting method, in every night 22:00~23:00 observes 15min with torch for illumination at the scene, takes the mean as density before going out（Unit is
Head/min）, 24h in kind records result after dispenser, Continuous Observation 7d, later respectively at 15d, 30d, 60d, 90d,
120d, 150d, 180d are respectively observed once, and are calculated as follows：
Killing rate（%）=
Measurement result is as follows（Table 2 and table 3）：
The Groton bug of table -6 scene is gone out roach result of the test（In 30d）
Measurement result in 30d shows, 0.5% ethiprole Nylar glue bait prepared by preparation method of the present invention compared to single dose and
0.5% ethiprole Nylar glue bait prepared by non-invention preparation method has roach effect of faster more thoroughly going out, 5d killing rate
It can reach 100%；0.5% ethiprole Nylar glue bait and the ethiprole glue bait of single dose 0.05% prepared by non-invention preparation method
Then killing rate can be only achieved 100% after even 15d after 7d, and killing rate is all extremely difficult in the Nylar glue bait 30d of single dose 0.45%
50%。
The Groton bug of table -7 scene is gone out roach result of the test（60~180d）
60 ~ 180d measurement result shows, in 0.5% ethiprole Nylar glue bait 180d prepared by preparation method of the present invention all
About more than 90% killing rate can be kept, it is very good to the prevention effect of blattaria population density；It is prepared by non-invention preparation method
0.5% ethiprole Nylar glue bait 60d after i.e. be extremely difficult to more than 90% killing rate, to blattaria population density preventing and treating effect
Fruit slightly has defect；And population density starts gradually to recover after the ethiprole glue bait 60d of single dose 0.05%, it is recovered during to 90d will
Nearly half, the roach long-term effect that goes out is not ideal, and the Nylar glue bait killing rate after 90d of single dose 0.45% can be only achieved more than 70%,
And more than 90% density domination rate is all not reaching to during entirely testing.
By above-mentioned pharmacodynamic results, present invention compounding has killing for faster killing effect and Geng Gao compared to Nylar single dose
Go out rate；It is also more preferable compared to chlopyrifos single dose killing effect, and long-term control effect more shows absolute advantage；And compared to non-
Glue bait prepared by preparation method of the present invention, because active ingredient of the present invention is embedded using particular polymer micro-sphere method, carry
High palatability, blattaria prefer feeding, so as to improve quick-acting and killing rate, Nylar are further compounded, because its is right
There is very high killing ability in nymph and ovum, so as to improve long-acting population density control effect.
For other compoundings of the present invention, it may have similar effect, do not outline one by one herein.
A kind of hygienic biocide composition containing Nylar of the present invention and its application are retouched by specific example
State, those skilled in the art can use for reference present invention, appropriate feed change, process conditions, active ingredient compounded combination or ratio
The links such as example realize corresponding other purposes, and its correlation changes all without departing from present disclosure, all similar replacements
With change it will become apparent to those skilled in the art that being considered as being included within the scope of the present invention.
Claims (10)
- A kind of 1. hygienic biocide composition containing Nylar, it is characterised in that the composition contains active component A and B, and two The weight ratio of person is 1:99~99:1；The active component A is Nylar；The active component B be selected from ethiprole, ethiprole, Rynaxypyr, fluorobenzene insect amide, orthene, chlopyrifos, Arprocarb, imidacloprid, MTI-446, clothianidin, indoxacarb, AVM, emamectin-benzoate or ivermectin In one or more；The composition contains selected from poly-lactic acid ester, polyhydroxyalkanoate or beta cyclodextrin as occlusion vehicle, the activearm It is 1 to divide A and B total amount and the weight ratio of occlusion vehicle:3-1:5；The hygienic biocide composition is glue bait, particle bait formulation, liquid bait formulation or concentration bait formulation.
- 2. hygienic biocide composition according to claim 1, it is characterised in that the active component B is ethiprole, chlorine worm Benzamide, MTI-446, indoxacarb or emamectin-benzoate.
- 3. hygienic biocide composition according to claim 1, it is characterised in that the active component B is ethiprole or first Amino abamectin benzoate.
- 4. hygienic biocide composition according to claim 1, it is characterised in that in the hygienic biocide composition, pyrrole third The weight of ether and B component ratio is 1:50~50:1.
- 5. hygienic biocide composition according to claim 1, it is characterised in that in the hygienic biocide composition, pyrrole third The weight of ether and B component ratio is 1:5~5:1.
- 6. hygienic biocide composition according to claim 1, it is characterised in that the occlusion vehicle is poly-hydroxy fatty acid Ester.
- 7. hygienic biocide composition according to claim 1, it is characterised in that active component A and B total amount carry with embedding The weight ratio of body is 1:4.
- 8. hygienic biocide composition according to claim 1, it is characterised in that the composition is glue bait or granulated bait Agent.
- 9. the preparation method of hygienic biocide composition according to any one of claims 1 to 7, it is characterised in that methods described Comprise the following steps：Step 1：The preparation of polymer microballoon：Active component A, B, occlusion vehicle are dissolved in by weight the third of 3-5 times in proportion In ketone, dichloroethanes or water, polymer microballoon is made after drying in subsequent spray；Step 2：According to a conventional method with glue bait, particle bait formulation, liquid bait formulation or the substrate for concentrating bait formulation, then add The polymer microballoon of step 1, final glue bait, particle bait formulation, liquid bait formulation or concentration bait formulation is made.
- 10. hygienic biocide composition according to any one of claims 1 to 7 is used for the purposes for preventing and treating sanitary insect pest, described to defend Raw insect is blattaria.
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Cited By (6)
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| CN108432770A (en) * | 2018-04-04 | 2018-08-24 | 北京科发伟业农药技术中心 | Rynaxypyr is used to prevent the purposes of agriculturally maggot shape pest |
| WO2019005700A1 (en) * | 2017-06-26 | 2019-01-03 | Merial, Inc. | Dual active parasiticidal granule compositions, methods and uses thereof |
| CN109430274A (en) * | 2018-12-13 | 2019-03-08 | 郭少波 | A kind of composition of pyriproxyfen-containing and dinotefuran killing sanitary insect pest |
| CN112998024A (en) * | 2019-12-20 | 2021-06-22 | 江苏功成生物科技有限公司 | Insecticidal composition containing fenoxycarb and application thereof |
| CN113575603A (en) * | 2021-08-26 | 2021-11-02 | 青岛润农化工有限公司 | Suspoemulsion containing fipronil and pyriproxyfen and preparation method and application thereof |
| CN115530174A (en) * | 2021-06-29 | 2022-12-30 | 青岛润农化工有限公司 | Dispersible oil suspending agent containing fipronil and pyriproxyfen and preparation method and application thereof |
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| CN104206393A (en) * | 2014-09-01 | 2014-12-17 | 中国农业科学院植物保护研究所 | Abamectin B2 microsphere and preparation method of abamectin B2 microsphere |
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| WO2019005700A1 (en) * | 2017-06-26 | 2019-01-03 | Merial, Inc. | Dual active parasiticidal granule compositions, methods and uses thereof |
| US11147273B2 (en) | 2017-06-26 | 2021-10-19 | Boehringer Ingelheim Animal Health USA Inc. | Dual active parasiticidal granule compositions, methods and uses thereof |
| CN108432770A (en) * | 2018-04-04 | 2018-08-24 | 北京科发伟业农药技术中心 | Rynaxypyr is used to prevent the purposes of agriculturally maggot shape pest |
| CN109430274A (en) * | 2018-12-13 | 2019-03-08 | 郭少波 | A kind of composition of pyriproxyfen-containing and dinotefuran killing sanitary insect pest |
| CN112998024A (en) * | 2019-12-20 | 2021-06-22 | 江苏功成生物科技有限公司 | Insecticidal composition containing fenoxycarb and application thereof |
| CN115530174A (en) * | 2021-06-29 | 2022-12-30 | 青岛润农化工有限公司 | Dispersible oil suspending agent containing fipronil and pyriproxyfen and preparation method and application thereof |
| CN113575603A (en) * | 2021-08-26 | 2021-11-02 | 青岛润农化工有限公司 | Suspoemulsion containing fipronil and pyriproxyfen and preparation method and application thereof |
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