CN115530174A - Dispersible oil suspending agent containing fipronil and pyriproxyfen and preparation method and application thereof - Google Patents
Dispersible oil suspending agent containing fipronil and pyriproxyfen and preparation method and application thereof Download PDFInfo
- Publication number
- CN115530174A CN115530174A CN202110725353.8A CN202110725353A CN115530174A CN 115530174 A CN115530174 A CN 115530174A CN 202110725353 A CN202110725353 A CN 202110725353A CN 115530174 A CN115530174 A CN 115530174A
- Authority
- CN
- China
- Prior art keywords
- pyriproxyfen
- dispersible oil
- fipronil
- suspending agent
- emulsifier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000005927 Pyriproxyfen Substances 0.000 title claims abstract description 63
- NHDHVHZZCFYRSB-UHFFFAOYSA-N pyriproxyfen Chemical compound C=1C=CC=NC=1OC(C)COC(C=C1)=CC=C1OC1=CC=CC=C1 NHDHVHZZCFYRSB-UHFFFAOYSA-N 0.000 title claims abstract description 63
- ZOCSXAVNDGMNBV-UHFFFAOYSA-N 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile Chemical compound NC1=C(S(=O)C(F)(F)F)C(C#N)=NN1C1=C(Cl)C=C(C(F)(F)F)C=C1Cl ZOCSXAVNDGMNBV-UHFFFAOYSA-N 0.000 title claims abstract description 57
- 239000005899 Fipronil Substances 0.000 title claims abstract description 57
- 229940013764 fipronil Drugs 0.000 title claims abstract description 57
- 239000000375 suspending agent Substances 0.000 title claims abstract description 49
- 238000002360 preparation method Methods 0.000 title abstract description 33
- 239000003921 oil Substances 0.000 claims abstract description 49
- 239000002270 dispersing agent Substances 0.000 claims abstract description 28
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 28
- 239000003381 stabilizer Substances 0.000 claims abstract description 28
- 239000002562 thickening agent Substances 0.000 claims abstract description 28
- 239000002612 dispersion medium Substances 0.000 claims abstract description 19
- 239000004480 active ingredient Substances 0.000 claims abstract description 14
- 235000019198 oils Nutrition 0.000 claims description 44
- HVLLSGMXQDNUAL-UHFFFAOYSA-N triphenyl phosphite Chemical compound C=1C=CC=CC=1OP(OC=1C=CC=CC=1)OC1=CC=CC=C1 HVLLSGMXQDNUAL-UHFFFAOYSA-N 0.000 claims description 20
- 239000003814 drug Substances 0.000 claims description 18
- -1 styryl phenol Chemical compound 0.000 claims description 17
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 16
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 15
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims description 13
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 12
- 239000000440 bentonite Substances 0.000 claims description 12
- 229910000278 bentonite Inorganic materials 0.000 claims description 12
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 12
- 239000012053 oil suspension Substances 0.000 claims description 12
- 229920001400 block copolymer Polymers 0.000 claims description 11
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 claims description 11
- QYDYPVFESGNLHU-UHFFFAOYSA-N elaidic acid methyl ester Natural products CCCCCCCCC=CCCCCCCCC(=O)OC QYDYPVFESGNLHU-UHFFFAOYSA-N 0.000 claims description 11
- 229910021485 fumed silica Inorganic materials 0.000 claims description 11
- QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 claims description 11
- 229940073769 methyl oleate Drugs 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 10
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 10
- 229920000053 polysorbate 80 Polymers 0.000 claims description 10
- 241000607479 Yersinia pestis Species 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 8
- 238000010008 shearing Methods 0.000 claims description 8
- 238000000227 grinding Methods 0.000 claims description 7
- 239000003549 soybean oil Substances 0.000 claims description 7
- 235000012424 soybean oil Nutrition 0.000 claims description 7
- 241000258937 Hemiptera Species 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 5
- 229920005551 calcium lignosulfonate Polymers 0.000 claims description 5
- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 claims description 5
- 239000004202 carbamide Substances 0.000 claims description 5
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 claims description 4
- 241001466042 Fulgoromorpha Species 0.000 claims description 4
- 229960000892 attapulgite Drugs 0.000 claims description 4
- 239000004359 castor oil Substances 0.000 claims description 4
- 235000019438 castor oil Nutrition 0.000 claims description 4
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 4
- 150000004702 methyl esters Chemical class 0.000 claims description 4
- 229910052625 palygorskite Inorganic materials 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 3
- 241001124076 Aphididae Species 0.000 claims description 3
- 235000019484 Rapeseed oil Nutrition 0.000 claims description 3
- 241001414989 Thysanoptera Species 0.000 claims description 3
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 3
- 150000002191 fatty alcohols Chemical class 0.000 claims description 3
- 229940083466 soybean lecithin Drugs 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 2
- 239000000725 suspension Substances 0.000 abstract description 12
- 239000012752 auxiliary agent Substances 0.000 abstract description 7
- 238000005338 heat storage Methods 0.000 abstract description 7
- 238000005457 optimization Methods 0.000 abstract description 6
- 238000002425 crystallisation Methods 0.000 abstract description 4
- 230000008025 crystallization Effects 0.000 abstract description 4
- 230000001804 emulsifying effect Effects 0.000 abstract description 4
- 230000032798 delamination Effects 0.000 abstract description 3
- 238000009776 industrial production Methods 0.000 abstract description 2
- 238000001556 precipitation Methods 0.000 abstract description 2
- 230000008719 thickening Effects 0.000 abstract description 2
- 239000000575 pesticide Substances 0.000 description 24
- 238000012360 testing method Methods 0.000 description 12
- 238000011282 treatment Methods 0.000 description 12
- 230000000052 comparative effect Effects 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 229940079593 drug Drugs 0.000 description 8
- 239000006185 dispersion Substances 0.000 description 7
- 238000009472 formulation Methods 0.000 description 7
- 230000000749 insecticidal effect Effects 0.000 description 7
- 239000002609 medium Substances 0.000 description 7
- 238000005507 spraying Methods 0.000 description 7
- 230000002195 synergetic effect Effects 0.000 description 7
- 230000000295 complement effect Effects 0.000 description 6
- 230000000857 drug effect Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 241000238631 Hexapoda Species 0.000 description 5
- 241000227653 Lycopersicon Species 0.000 description 5
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- 230000015556 catabolic process Effects 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000013329 compounding Methods 0.000 description 4
- 238000006731 degradation reaction Methods 0.000 description 4
- 238000002844 melting Methods 0.000 description 4
- 230000008018 melting Effects 0.000 description 4
- 238000001228 spectrum Methods 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 239000002917 insecticide Substances 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 230000000361 pesticidal effect Effects 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 241000255925 Diptera Species 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 241000255777 Lepidoptera Species 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 239000004495 emulsifiable concentrate Substances 0.000 description 2
- 238000003912 environmental pollution Methods 0.000 description 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 2
- 229940044652 phenolsulfonate Drugs 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- 239000004563 wettable powder Substances 0.000 description 2
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 1
- OEDUIFSDODUDRK-UHFFFAOYSA-N 5-phenyl-1h-pyrazole Chemical compound N1N=CC=C1C1=CC=CC=C1 OEDUIFSDODUDRK-UHFFFAOYSA-N 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 108010062745 Chloride Channels Proteins 0.000 description 1
- 102000011045 Chloride Channels Human genes 0.000 description 1
- 241001414720 Cicadellidae Species 0.000 description 1
- 241001498622 Cixius wagneri Species 0.000 description 1
- 241000254173 Coleoptera Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 102000005915 GABA Receptors Human genes 0.000 description 1
- 108010005551 GABA Receptors Proteins 0.000 description 1
- 241000227425 Pieris rapae crucivora Species 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229930014550 juvenile hormone Natural products 0.000 description 1
- 239000002949 juvenile hormone Substances 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 239000004533 oil dispersion Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000012865 response to insecticide Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000012430 stability testing Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000004548 suspo-emulsion Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000004557 technical material Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 239000004562 water dispersible granule Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a dispersible oil suspending agent containing fipronil and pyriproxyfen, a preparation method and application thereof, wherein the dispersible oil suspending agent comprises the following components in percentage by weight: 5-30% of active ingredients, 6-20% of emulsifier, 1-8% of dispersant, 1-8% of thickener, 0.5-2% of stabilizer and the balance of dispersion medium to 100%. The dispersible oil suspending agent disclosed by the invention is simple in preparation process, easy to operate, environment-friendly and safe in preparation process, free of pollution problem, low in cost and easy for industrial production. The obtained dispersible oil suspending agent has good emulsifying dispersibility, low liability to thickening, bottom precipitation, crystallization and delamination, less residue after pouring, high suspension rate, and good heat storage stability. Through the optimization of each auxiliary agent, the residue of the obtained dispersible oil suspending agent after pouring is lower than 1.2%, and the suspension rate before and after heat storage can reach more than 95%.
Description
Technical Field
The invention relates to a pesticide dispersible oil suspending agent, in particular to a dispersible oil suspending agent containing fipronil and pyriproxyfen, a preparation method and application thereof, and belongs to the technical field of pesticides.
Background
Fipronil is a novel broad-spectrum insecticide of phenylpyrazole type developed by original French Rona-Planck company in 1981, has the chemical name of (RS) -5-amino-1- (2, 6-dichloro-a, a, a-trifluoro-p-tolyl) -4-trifluoromethyl sulfinyl pyrazole-3-nitrile, has the action mechanism of combining with a gamma-aminobutyric acid receptor, effectively blocks a chloride ion channel regulated by systemic gamma-aminobutyric acid in the insect center, interferes with the insect center nervous system, and causes the overexcitation of insect nerves and muscles until death. The pesticide composition has stomach poisoning effect on pests, has contact killing and certain systemic effect, has high activity on important pests such as aphids, leafhoppers, plant hoppers, lepidoptera larvae, flies, coleoptera and the like, and has no pesticide damage on crops.
Pyriproxyfen, also known as Mianbao and pyriproxyfen, has a chemical name of 4-phenoxyphenyl- (RS) -2- (2-pyridyloxy) propyl ether, is an alkoxy pyridine juvenile hormone type chitin synthesis inhibitor which is created and developed by Nippon Sumitomo company in 1983, can be used for controlling homoptera, thysanoptera, diptera and lepidoptera pests, and is widely applied to fruits, vegetables, cotton, ornamental plants and public health.
Pesticide varieties containing a single active ingredient often have different degrees of defects in agricultural pest control, such as: the insecticidal spectrum is narrow, the insecticide resistance is easy to generate after continuous use, and the environmental pollution is aggravated by a plurality of use times. The above disadvantages can be effectively overcome by compounding active ingredients with different mechanisms of action. Meanwhile, the synergistic effect generated by mixing the two active components can improve the control effect, expand the insecticidal spectrum, delay the generation of the drug resistance of pests and reduce the environmental pollution, thereby being an important means for comprehensively controlling the pests. Currently, fipronil and pyriproxyfen are used in combination for killing insects, for example, patent CN103355324A.
At present, the common formulations of the pesticide comprise wettable powder, water dispersible granules, missible oil, aqueous solution, suspending agent and the like, the main formulation of the fipronil is the water suspending agent, and the main formulation of the pyriproxyfen is the missible oil. The missible oil contains low-boiling-point toxic and harmful solvents such as dimethylbenzene and benzene, and the water suspending agent is easy to generate unstable phenomena such as deposition, layering and the like, so that the pesticide effect is seriously influenced. The dispersible Oil suspending agent is a pesticide preparation with development prospect, the dispersible Oil suspending agent refers to a liquid preparation with active ingredients stably suspended in liquid immiscible with water, the Oil suspending agent is diluted and prepared by water, and the English name of the dispersible Oil suspending agent is Oil-based dispersion concentrations or Oil dispersion, called OD for short. The dispersible oil suspending agent is directly diluted by water before use, and is different from the oil suspending agent in that the dispersible oil suspending agent needs to be diluted by an organic solvent before use. The dispersible oil suspending agent selects oil auxiliary agents with good adhesion and spreadability as dispersing and diluting carriers, and is easy to adhere to waxy or smooth leaf surfaces, so that the dispersible oil suspending agent has the advantages of good adhesion and spreadability, strong permeation conductivity, strong rain wash resistance and the like when in use. The dispersible oil suspending agent is more stable than a water suspending agent in performance, has no dust in the production and use processes, uses environment-friendly solvent oil, is not easy to cause pollution to the environment, people and livestock, is more environment-friendly than missible oil and wettable powder, and has better drug effect. At present, fipronil and pyriproxyfen are not reported in dispersible oil suspending agents.
Disclosure of Invention
The invention aims to provide a dispersible oil suspending agent containing fipronil and pyriproxyfen, which has the characteristics of good emulsifying dispersibility, high suspension rate and good stability by matching and selecting auxiliaries and is more beneficial to the exertion of the drug effects of the fipronil and the pyriproxyfen.
Fipronil is a white solid with a melting point of 200-201 ℃ and a density of 1.477-1.626 (20 ℃), a pyriproxyfen original drug is a light yellow crystal with a melting point of 45-47 ℃ and a relative density of 1.23. The fipronil and the pyriproxyfen have high lipophilicity, the melting point of the pyriproxyfen is low, the two components are difficult to be prepared into dispersible oil suspending agents in a mixing mode, and the original drug particles are easy to crystallize and stratify in a suspension dispersion system. In addition, the pyriproxyfen is easy to decompose under the high-temperature storage condition due to the low melting point of the technical material and the chiral pesticide property, and the fipronil and the pyriproxyfen dispersible oil suspending agent are easy to degrade under the high-temperature storage condition, so that the pesticide effect is influenced. In order to solve these problems, it is difficult to select an auxiliary, and if the auxiliary is not properly selected, the resulting preparation tends to suffer from problems such as delamination, crystallization, and degradation of the active ingredient of the drug, which may affect the efficacy of the drug. The inventor carries out a large amount of screening work on an auxiliary system, finally obtains the optimal auxiliary composition, greatly reduces the processing difficulty of the preparation formulation through the synergistic matching of all the auxiliaries, particularly the synergistic matching of 3 auxiliaries of an emulsifier, a dispersing agent and a thickening agent, improves the stability of the preparation formulation, and inhibits the degradation of active ingredients of medicaments through the addition of a stabilizer.
The dispersible oil suspending agent containing fipronil and pyriproxyfen comprises the following components in percentage by weight: 5-30% of active ingredients, 6-20% of emulsifier, 1-8% of dispersant, 1-8% of thickener, 0.5-2% of stabilizer and the balance of dispersion medium to 100%.
Further, the dispersible oil suspending agent preferably consists of the following components in percentage by weight: 5-30% of active ingredients of the medicine, 10-20% of emulsifier, 4-7% of dispersant, 2-6% of thickening agent, 0.8-2% of stabilizing agent and dispersion medium which is added to 100%.
Further, the effective components are fipronil and pyriproxyfen. Preferably, the mass ratio of the fipronil to the pyriproxyfen is 0.05-20.
Further, the emulsifier is one or more of polyoxyethylene sorbitan monooleate, styryl phenol polyoxyethylene ether, castor oil polyoxyethylene ether, calcium dodecyl benzene sulfonate, fatty alcohol polyoxyethylene ether and alkylphenol polyoxyethylene ether.
Further, the dispersant is one or more of calcium lignosulfonate, sodium alkylphenol sulfonate, polyoxyethylene-polyoxypropylene block copolymer and alkyl naphthalene sulfonate formaldehyde condensate.
Further, the thickener is one or more of fumed silica, organic bentonite, attapulgite and urea.
Further, the stabilizer is one or more of butyl hydroxy anisole, triphenyl phosphite, epichlorohydrin and soybean lecithin.
Furthermore, the dispersion medium is one or more of soybean oil, methyl oleate, rapeseed oil and soybean oil methyl ester, and the dispersion medium used in the invention is an environment-friendly solvent, so that the environment is protected, the compatibility of the components is good, and the stability of the product is improved.
Furthermore, the dispersible oil suspending agent solves or reduces the defects existing when fipronil and pyriproxyfen are prepared into the preparation through the selection of the emulsifying agent, the dispersing agent, the thickening agent, the stabilizing agent and the dispersing medium, and the obtained dispersible oil suspending agent has the advantages of good dispersion stability, high suspension rate, good heat storage stability and the like. Preferably, the emulsifier is prepared by mixing polyoxyethylene sorbitan monooleate and calcium dodecylbenzene sulfonate according to the mass ratio of 1-3; the dispersing agent is formed by mixing a polyoxyethylene-polyoxypropylene segmented copolymer and an alkyl naphthalene sulfonate formaldehyde condensate according to the mass ratio of 2-4; the thickener is formed by mixing fumed silica and organic bentonite according to the mass ratio of 1; the stabilizer is triphenyl phosphite; the dispersion medium is methyl oleate. The optimization of the auxiliary agents is more beneficial to the optimization of the performance of the preparation and the exertion of the drug effect of the active ingredients, particularly, the optimization of the emulsifying agent, the dispersing agent and the thickening agent has better promotion effect on the performance and the exertion of the drug effect of the preparation, and the optimization of the stabilizing agent can better inhibit the degradation of the active ingredients.
The invention also provides a preparation method of the dispersible oil suspending agent, which comprises the following steps: adding a dispersion medium, an emulsifier, a dispersant and a stabilizer into a reaction kettle, and fully mixing and uniformly dispersing; adding the thickening agent, fipronil and pyriproxyfen into the reaction kettle under the high-speed shearing state, shearing for 10-30 minutes, and then grinding until the particle diameter D of the mixture is 90 And (5) obtaining the dispersible oil suspending agent containing fipronil and pyriproxyfen, wherein the particle size of the dispersible oil suspending agent is less than 4 mu m.
In the preparation method, the shearing speed of high-speed shearing is 1000-10000r/min.
In the above preparation method, the grinding can be carried out as disclosed in the prior artFor example, grinding may be performed under zirconia bead grinding media. After grinding, detecting by a laser particle size distribution instrument until the particle diameter D 90 Less than 4 mu m.
The dispersible oil suspending agent can improve the insecticidal effect of the agent, expand the insecticidal spectrum and improve the safety of crops by compounding the fipronil and the pyriproxyfen according to a specific ratio; by selecting the auxiliary agent, the emulsifying dispersibility, the suspension rate and the stability of the preparation are improved. The dispersible oil suspending agent has a good application prospect in the aspect of preventing and treating crop pests, and has a good prevention and treatment effect on aphids, plant hoppers, whiteflies, thrips and the like.
The invention has the following beneficial effects:
1. the active ingredients fipronil and pyriproxyfen of the pesticide belong to two insecticides with different action mechanisms, and the two insecticides are mixed with each other without conflict, so that the insecticidal spectrum is expanded, the insecticidal efficiency is improved, and the pesticide has obvious synergistic effect.
2. According to the invention, through the screening and matching of the emulsifier, the dispersant and the thickener, the stability of the product is improved, and the problems of crystallization and layering of the preparation are reduced or solved.
3. The invention effectively inhibits the degradation of the pyriproxyfen under high-temperature storage by adding the stabilizer.
4. The dispersible oil suspending agent is convenient to use, can be used for conventional spraying and spraying of a plant protection unmanned aerial vehicle, and has the advantages of difficult volatilization of liquid medicine, drift resistance, strong permeation conductivity, rain wash resistance and high target bioactivity.
5. The dispersible oil suspending agent disclosed by the invention is simple in preparation process, easy to operate, environment-friendly and safe in preparation process, free of pollution problem, low in cost and easy for industrial production. The obtained dispersible oil suspending agent has good emulsifying dispersibility, low probability of thickening, bottom precipitation, crystallization and delamination, less residue after pouring, high suspension rate and good heat storage stability. Through the optimization of each auxiliary agent, the residue of the obtained dispersible oil suspending agent after pouring is lower than 1.2%, and the suspension rate before and after heat storage can reach more than 95%.
Detailed Description
The invention is further illustrated by the following specific examples, which are intended to be purely exemplary and are not intended to be limiting.
Unless otherwise specified, the following percentages are by weight.
The insecticidal compounding synergistic ratio of the fipronil and the pyriproxyfen is measured by an indoor toxicity experiment. Indoor toxicity determination is carried out according to the Sun Yunpei method, the co-toxicity coefficient (CTC) of the two medicaments compounded according to a certain proportion is determined, the CTC is less than 80 and is antagonistic, the CTC is more than or equal to 80 and is less than or equal to 120 and is additive, and the CTC is more than 120 and is synergistic.
Indoor toxicity determination of fipronil and pyriproxyfen compounded on rice planthopper nymphs
The test agents were provided by Shandong Weifang Runfeng Feng chemical company Limited.
And (3) experimental design: after the effective inhibition concentration range of each medicament is determined through pre-test, each medicament is respectively treated with a series of concentrations according to the content of effective components, and clear water is used for comparison. The method is carried out according to the standard pesticide for indoor bioassay of pesticides, the lethal medium concentration of the pesticide and the mixed pesticide is measured by adopting an insect soaking method, and the cotoxicity coefficient is obtained by a method for calculating the combined toxicity provided by Sun Yunpei et al (1960).
The calculation formula is as follows (using fipronil as standard medicament, the virulence index is 100)
In the formula: m is a mixture of fipronil and pyriproxyfen in different proportions;
P fipronil Is the proportion of fipronil in the compound composition;
P pyriproxyfen Is the proportion of the pyriproxyfen in the compound composition.
The test results are shown in table 1:
as can be seen from Table 1, the LC of fipronil and pyriproxyfen for the nymphs of rice planthoppers 50 1.18mg/L and 74.10mg/L, respectively. When the mass ratio of fipronil to pyriproxyfen is within the range of 20-1 to 20, the cotoxicity coefficient is more than 120, and the synergistic effect is shown, but the additive effect is shown when the mass ratio of fipronil to pyriproxyfen is 1.
In the following, several examples of dispersible oil suspensions of the present invention are listed to further illustrate the invention.
Example 1
The formula is as follows: 1% of fipronil, 4% of pyriproxyfen, 4% of castor oil polyoxyethylene ether serving as an emulsifier, 6% of alkylphenol polyoxyethylene, 1% of calcium lignosulfonate serving as a dispersant, 1% of polyoxyethylene-polyoxypropylene block copolymer, 2% of fumed silica serving as a thickener, 4% of attapulgite, 1.5% of butyl hydroxy anisole serving as a stabilizer and the balance of soybean oil serving as a dispersion medium to 100%.
The preparation method comprises the following steps: adding a dispersion medium, an emulsifier, a dispersant and a stabilizer into a reaction kettle, and fully mixing and uniformly dispersing; adding the thickening agent, fipronil and pyriproxyfen into the reaction kettle under the high-speed shearing state of 1000r/min, shearing for 10-30 minutes, and then grinding until the particle diameter D of the mixture is 90 And (5) obtaining the dispersible oil suspending agent containing fipronil and pyriproxyfen, wherein the particle size of the dispersible oil suspending agent is less than 4 mu m.
Example 2
The formula is as follows: fipronil 5%, pyriproxyfen 5%, emulsifier polyoxyethylene sorbitan monooleate 6%, calcium dodecylbenzene sulfonate 6%, dispersant polyoxyethylene-polyoxypropylene block copolymer 3%, alkyl naphthalene sulfonate formaldehyde condensate 1%, thickener fumed silica 1%, organic bentonite 4%, stabilizer triphenyl phosphite 1.2%, and dispersing medium methyl oleate complement 100%. The preparation method is the same as example 1.
Example 3
The formula is as follows: fipronil 5%, pyriproxyfen 7%, emulsifier styrylphenol polyoxyethylene ether 8%, fatty alcohol polyoxyethylene ether 9%, dispersant sodium alkyl phenol sulfonate 2%, polyoxyethylene-polyoxypropylene block copolymer 1%, thickener organic bentonite 3%, urea 1%, stabilizer epichlorohydrin 1.0%, and dispersion medium rapeseed oil complement 100%. The preparation method is the same as example 1.
Example 4
The formula is as follows: fipronil 10%, pyriproxyfen 5%, emulsifier polyoxyethylene sorbitan monooleate 8%, calcium dodecylbenzene sulfonate 6%, dispersant polyoxyethylene-polyoxypropylene block copolymer 3%, alkyl naphthalene sulfonate formaldehyde condensate 1.5%, thickener fumed silica 1%, organic bentonite 3%, stabilizer triphenyl phosphite 1.1%, and dispersing medium methyl oleate complement 100%. The preparation method is the same as example 1.
Example 5
The formula is as follows: fipronil 10%, pyriproxyfen 1%, emulsifier calcium dodecylbenzene sulfonate 10%, polyoxyethylene sorbitan monooleate 4%, dispersant sodium alkyl phenol sulfonate 2%, polyoxyethylene-polyoxypropylene block copolymer 1%, thickener attapulgite 2%, urea 2%, stabilizer soybean lecithin 0.8%, and dispersion medium soybean oil methyl ester complement 100%. The preparation method is the same as example 1.
Example 6
The formula is as follows: 12% of fipronil, 8% of pyriproxyfen, 12% of emulsifier polyoxyethylene sorbitan monooleate, 4% of calcium dodecyl benzene sulfonate, 4% of dispersant polyoxyethylene-polyoxypropylene block copolymer, 1% of alkyl naphthalene sulfonate formaldehyde condensate, 1.5% of thickener fumed silica, 1.5% of organic bentonite, 1% of stabilizer triphenyl phosphite and the balance of dispersion medium methyl oleate to 100%. The preparation method is the same as example 1.
Example 7
The formula is as follows: 10% of fipronil, 12% of pyriproxyfen, 11% of emulsifier styryl phenol polyoxyethylene ether, 6% of castor oil polyoxyethylene ether, 3% of dispersant calcium lignosulfonate, 2% of alkyl naphthalene sulfonate formaldehyde condensate, 2% of thickener organic bentonite, 1% of urea, 0.9% of stabilizer epichlorohydrin, and the balance of dispersion medium methyl oleate for 100%. The preparation method is the same as example 1.
Example 8
The formula is as follows: fipronil 10%, pyriproxyfen 15%, emulsifier calcium dodecylbenzene sulfonate 12%, styrylphenol polyoxyethylene ether 6%, dispersant calcium lignosulfonate 3%, polyoxyethylene-polyoxypropylene block copolymer 3%, thickener fumed silica 1.5%, organic bentonite 0.5%, stabilizer triphenyl phosphite 0.8%, and dispersion medium soybean oil methyl ester make up to 100%. The preparation method is the same as example 1.
Example 9
The formula is as follows: fipronil 15%, pyriproxyfen 15%, emulsifier polyoxyethylene sorbitan monooleate 15%, calcium dodecylbenzene sulfonate 5%, dispersant polyoxyethylene-polyoxypropylene block copolymer 4%, alkyl naphthalene sulfonate formaldehyde condensate 3%, thickener fumed silica 0.5%, organic bentonite 1.5%, stabilizer triphenyl phosphite 2%, and dispersing medium methyl oleate complement 100%. The preparation method is the same as example 1.
Comparative example 1
The formula is as follows: fipronil 10%, pyriproxyfen 5%, emulsifier polyoxyethylene ether carboxylate 8%, fatty acid polyoxyethylene ester phosphate 6%, dispersant naphthalenesulfonic acid formaldehyde condensate sodium salt 3%, alkylphenol polyoxyethylene ether phosphate 2%, thickener magnesium aluminum silicate 3%, common white carbon black 1%, stabilizer triphenyl phosphite 1.1%, and dispersing medium methyl oleate complement 100%. The preparation method is the same as example 1.
Comparative example 2
The formula is as follows: fipronil 10%, pyriproxyfen 5%, emulsifier polyoxyethylene sorbitan monooleate 8%, calcium dodecylbenzene sulfonate 6%, dispersant polyoxyethylene-polyoxypropylene block copolymer 3%, alkyl naphthalene sulfonate formaldehyde condensate 1.5%, thickener fumed silica 1%, organic bentonite 3%, and dispersing medium methyl oleate to make up 100%. The preparation method is the same as example 1.
The properties of the dispersible oil suspension concentrates prepared in the above examples and comparative examples were measured, and the results are shown in table 2 below. Wherein, the suspension percentage is detected according to a method for measuring the suspension percentage of the pesticide GB/T14825-2006, the pourability is detected according to a method for measuring the pourability of the pesticide GB/T31737-2015, the dispersion stability is detected according to CIPAC MT 180 measuring the dispersion stability of the suspoemulsion by the International Council of pesticide analysis and collaboration, and the heat storage stability is detected according to a method for measuring the heat storage stability of the pesticide GBT 19136-2003.
As can be seen from table 2, the products of examples 2, 4, 6, and 9 using the preferred adjuvants are stable in quality before and after hot storage, and maintain high suspension percentage, low pouring residue, and good dispersion stability, while the products of examples 1, 3, 5, 7, and 8 using non-preferred adjuvants are slightly inferior in hot storage stability to those of examples 2, 4, 6, and 9, but are also superior in performance, while comparative example 1 is poor in dispersion stability of the formulation and low in suspension percentage due to improper selection of the emulsifier, dispersant, and thickener. In addition, from examples 1-9, the formulations maintained better performance over 5-30% drug content.
Fipronil and pyriproxyfen dispersible oil suspending agents prepared in example 4 and comparative example 2 were subjected to drug stability testing: placing the dispersible oil suspending agent in a closed container, standing at 65 deg.C for 14 days, detecting the content difference of effective components of the medicine before and after standing by high performance liquid chromatography, and calculating the decomposition rate.
As can be seen from Table 3, in comparative example 2, the decomposition of pyriproxyfen is severe and reaches 21.57% without adding the stabilizer, while the decomposition of pyriproxyfen in example 4 with the stabilizer is slight (2.00%) and meets the product quality requirement.
Experiment of drug effect
Field test example: pesticide effect test for preventing and controlling tomato whitefly through field test
The test is carried out in vegetable bases of Shouguang city, shandong province, and the control agents are 5% fipronil suspending agent and 10% pyriproxyfen emulsifiable concentrate (purchased from the market). The total 4 treatments are respectively as follows: treatment 1: spraying with clear water, and blank control; and (3) treatment 2: fipronil pyriproxyfen dispersible oil suspension obtained in examples 4 and 7 and comparative example 1; and (3) treatment: 5% fipronil suspending agent; and (4) treatment: 10% pyriproxyfen emulsifiable concentrate.
In the examples 4 and 7 and the comparative example 1, the fipronil-pyriproxyfen dispersible oil suspension obtained in the example 3 was subjected to stem and leaf spraying treatment according to the effective component amount of 60 g/ha, the stem and leaf spraying treatment according to the effective component amount of 105 g/ha in the treatment 3 was subjected to stem and leaf spraying treatment according to the effective component amount of 90 g/ha in the treatment 4.
The tomato whitefly was in the prime stage when tested. The pesticide is applied for 1 time by a worker-farm-16 knapsack manual sprayer, 750kg of water is added to prepare the pesticide liquid according to the dosage of the preparation per hectare, and the uniform spraying is carried out according to the amount of the pesticide liquid in the community. The weather during the test is good, and the daily average temperature is 22-30.0 ℃. No rain appears on the day of drug application, and no rain appears within 21 days after drug application.
Investigating population base before applying the pesticide, investigating live insect quantity in 3 rd, 14 th and 21 th days after the pesticide, calculating population decline rate, and observing the safety of the test medicament to crops.
The survey statistical method comprises the following steps: at each survey of 15 crops identified per plot, the leaf backs were carefully examined without frightening the insects, the number of live adults was recorded, and the leaves were examined in the morning when the adults were less active.
As can be seen from the test results in the above table 4, the combination of fipronil and pyriproxyfen has good control effect on tomato whitefly, and the population reduction rate is superior to that of fipronil suspending agent and pyriproxyfen missible oil contrast agent. As can be seen from the comparison of the drug effects of the examples and the comparative examples, the selection of the auxiliary agent has an important influence on the exertion of the effective components, and improper selection of the auxiliary agent can influence the compounding effect of the fipronil and the pyriproxyfen. According to the observation of the whole field test process, the tomatoes have good growth vigor within the test dose range, and the pesticide damage phenomenon does not occur in each treatment agent, which indicates that the tomatoes are safe.
Claims (9)
1. A dispersible oil suspending agent containing fipronil and pyriproxyfen is characterized by comprising the following components in percentage by weight: 5-30% of active ingredients, 6-20% of emulsifier, 1-8% of dispersant, 1-8% of thickener, 0.5-2% of stabilizer and 100% of dispersion medium, wherein the active ingredients are fipronil and pyriproxyfen.
2. The dispersible oil suspension concentrate of claim 1, consisting of the following components in weight percent: 5-30% of active ingredients of the medicine, 10-20% of emulsifier, 4-7% of dispersant, 2-6% of thickening agent, 0.8-2% of stabilizing agent and dispersion medium which is added to 100%.
3. The dispersible oil suspension as claimed in claim 1 or 2, characterized in that: the mass ratio of fipronil to pyriproxyfen is 0.05-20.
4. The dispersible oil suspension of claim 1, wherein: the emulsifier is one or more of polyoxyethylene sorbitan monooleate, styryl phenol polyoxyethylene ether, castor oil polyoxyethylene ether, calcium dodecyl benzene sulfonate, fatty alcohol polyoxyethylene ether and alkylphenol polyoxyethylene ether; the dispersing agent is one or more of calcium lignosulfonate, sodium alkylphenol sulfonate, polyoxyethylene-polyoxypropylene block copolymer and alkyl naphthalene sulfonate formaldehyde condensate; the thickening agent is one or more of fumed silica, organic bentonite, attapulgite and urea; the stabilizer is one or more of butyl hydroxy anisole, triphenyl phosphite, epichlorohydrin and soybean lecithin; the dispersion medium is one or more of soybean oil, methyl oleate, rapeseed oil and soybean oil methyl ester.
5. The dispersible oil suspension of claim 1, wherein: the emulsifier is prepared by mixing polyoxyethylene sorbitan monooleate and calcium dodecyl benzene sulfonate according to the mass ratio of 1-3; the dispersing agent is formed by mixing a polyoxyethylene-polyoxypropylene segmented copolymer and an alkyl naphthalene sulfonate formaldehyde condensate according to the mass ratio of 2-4; the thickener is prepared by mixing fumed silica and organic bentonite according to a mass ratio of 1.
6. The dispersible oil suspension of claim 1, wherein: the stabilizer is triphenyl phosphite.
7. The dispersible oil suspension of claim 1, wherein: the dispersion medium is methyl oleate.
8. A method for preparing the dispersible oil suspension containing fipronil and pyriproxyfen of claim 1, which is characterized by comprising the following steps: adding a dispersion medium, an emulsifier, a dispersant and a stabilizer into a reaction kettle, and fully mixing and uniformly dispersing; adding the thickening agent, fipronil and pyriproxyfen into the reaction kettle under the high-speed shearing state, shearing for 10-30 minutes, and then grinding until the particle diameter D of the mixture is 90 Less than 4 mu m to obtain the dispersible oil suspending agent containing fipronil and pyriproxyfen; preferably, the shear rate is 1000 to 10000r/min.
9. The use of a dispersible oil suspension concentrate comprising fipronil and pyriproxyfen according to claim 1 for controlling pests on crops, preferably aphids, plant hoppers, whiteflies and thrips.
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| CN107787977A (en) * | 2017-08-28 | 2018-03-13 | 南通功成精细化工有限公司 | A kind of hygienic biocide composition containing Nylar and its application |
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| CN103355324A (en) * | 2013-06-29 | 2013-10-23 | 海利尔药业集团股份有限公司 | Insecticidal composition containing fipronil and pyriproxyfen |
| CN107787977A (en) * | 2017-08-28 | 2018-03-13 | 南通功成精细化工有限公司 | A kind of hygienic biocide composition containing Nylar and its application |
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