CN107737272A - A kind of Chinese medicine composition and its methods for making and using same with freckle removing and whitening effect - Google Patents
A kind of Chinese medicine composition and its methods for making and using same with freckle removing and whitening effect Download PDFInfo
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- A61K36/06—Fungi, e.g. yeasts
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Abstract
The invention discloses a kind of Chinese medicine preparation with freckle removing and whitening effect and preparation method thereof, belong to health nursing product technical field.The Chinese medicine preparation includes following raw material:4 18 parts of ganoderma lucidum, 9 36 parts of matsutake, 3 12 parts of ginseng, 14 parts of black bearberry leaf extract, 3 12 parts of sealwort, 3 12 parts of the bighead atractylodes rhizome, 16 parts of the bletilla striata, 3 12 parts of the root of herbaceous peony, 3 12 parts of radix ampelopsis, 3 12 parts of the larva of a silkworm with batrytis, 4 12 parts of Poria cocos, 16 parts of Radix Angelicae Sinensis, 39 parts of river Chinese herbaceous peony, 3 12 parts of the Radix Astragali, 15 parts of almond, 2 10 parts of coix seed, 15 parts of the fruit of summer cypress, 15 parts of the root bark of shaggy-fruited dittany, 15 parts of radix glycyrrhizae, 26 parts of peppermint.Whitening spot-removing skin care item provided by the invention do not stimulate gently, are applicable to sensitive skin crowd, easy to use, natural without any side effects, have good application prospect.
Description
Technical field
The present invention relates to belonging to health nursing product technical field, more particularly, to a kind of with freckle removing and whitening effect
Chinese medicine composition and its methods for making and using same.
Background technology
Melanin is present in the basal layer of epidermis iuntercellular of people.Skin Bai Bubai, it is black to depend primarily on melanocyte synthesis
The ability of pigment.Melanin generates much, and skin is more black;Conversely, then skin is more fair.Ultraviolet irradiation can make black
Element produces change, generates a kind of material for protecting skin, and moving layer by layer via cell metabolism, has arrived skin epidermis, from
And form that seen color spot, the colour of skin be irregular, the skin problem such as dark yellow.In female face pigmentation, tarnish, dark yellow etc.
The most commonly seen skin of face problem of the young women especially age working women, influences mood and the life of young and middle-aged women
It is living.
Tyrosinase is currently the only known enzyme in melanin metabolism.In the basal layer of epidermis iuntercellular of people, it is dispersed with black
Oxidizing tyrosine can be passed through a series of metabolic process again by chromatophore, the junket ammonia enzyme that it contains into polysaccharide, centre, finally
Melanin can be generated.Junket ammonia enzyme has played very important role during caused by melanin.Tyrosinase activity increases
Add, caused melanin will be more;Tyrosinase activity is suppressed, and the ability that melanocyte produces melanin just accordingly drops
It is low.It may be said that tyrosinase is exactly the key for controlling melanocyte activity, it determines the speed of B16 cell.Tyrosine
Enzymatic activity strengthens or pigment disorders, such as chloasma will occur for disorder.
Traditional skin-lightening cosmetic often uses chemical substance, such as hydrogen peroxide, ammoniated mercury and various phenols
Derivative, these compounds can be such that melanin tissue disintegrates rapidly, the effect of reaching quick whitening.But because it corrodes to skin
Property, the factor such as cytotoxicity and anaphylaxis, have it is greatly dangerous, it is disabled in many national hygienic practices.
Natural traditional Chinese medicine whitening composition sensitization rate is low, it is safe, have broad application prospects, as consumer is in natural
Medicine product is advocated, and people's Chinese medicine class skin-lightening cosmetic safe and effective, non-stimulated to those, which seems, particularly to be favored, therefore, from
The whitening active ingredients found in Chinese medicine efficiently, less toxic have been increasingly becoming the study hotspot of health nursing product technical field
One of.
But Chinese medicine cosmetic species is various at present, it is seldom really to form the prescription of monarch compatibility, Chinese medicine restriction or checking relation in five elements
Principle also cause many Chinese medicine materials cannot function as skin care item use.Even if it is according to " the monarch and his subjects help to have part Chinese medicine cosmetic
Make " thinking of making up a prescription, according to pharmacopeia recommended dose scope, the use for determining each taste Chinese medicine in prescription is integrated with reference to doctor personal experience
Amount, but this " dosage determination " based on experiential basis so that Chinese medicine cosmetic lacks the theoretical direction of science and effect is beaten greatly
Discount.
The content of the invention
In view of the above-mentioned problems existing in the prior art, this application provides.Whitening spot-removing skin care product temperature provided by the invention
Do not stimulate, be applicable to sensitive skin crowd, it is easy to use, natural without any side effects, there is good application prospect.
Technical scheme is as follows:
A kind of Chinese medicine composition with freckle removing and whitening effect, is made up of the raw material of following parts by weight:
Ganoderma lucidum 4-18 parts, matsutake 9-36 parts, ginseng 3-12 parts, black bearberry leaf extract 1-4 parts, sealwort 3-12 parts, bighead atractylodes rhizome 3-
12 parts, bletilla striata 1-6 parts, root of herbaceous peony 3-12 parts, radix ampelopsis 3-12 parts, larva of a silkworm with batrytis 3-12 parts, Poria cocos 4-12 parts, Radix Angelicae Sinensis 1-6 parts, river Chinese herbaceous peony 3-
9 parts, Radix Astragali 3-12 parts, almond 1-5 parts, coix seed 2-10 parts, fruit of summer cypress 1-5 parts, root bark of shaggy-fruited dittany 1-5 parts, radix glycyrrhizae 1-5 parts, peppermint
2-6 parts.
Present invention also provides the preparation method of above-mentioned Chinese medicine composition, the described method comprises the following steps:
(1) tunning of ganoderma lucidum and matsutake:4-18 parts ganoderma lucidum and 9-36 part matsutakes are weighed, after being milled to powder, is added
Distilled water is sterilized, and Lactobacillus lactis fermentation is bitten in inoculation, and fermentation condition is:At 37 DEG C, MRS formulas, quiescent culture 24h;80 DEG C afterwards
It is concentrated under reduced pressure to give medicinal extract.
(2) ginseng purification whitening material:3-12 part ginsengs are weighed, are milled to powder, deionization is added by solid-liquid ratio 1: 10
Water, decocting are boiled 3 times, each 2h;Merge extract solution, 4500r/min centrifugation 10min, collect supernatant, concentration, 80 DEG C of vacuum are done
Dry, obtained dried powder is ginseng skin-whitening crude extract;
(3) sealwort 3-12 parts, bighead atractylodes rhizome 3-12 parts, bletilla striata 1-6 parts, root of herbaceous peony 3-12 parts, radix ampelopsis 3-12 parts, larva of a silkworm with batrytis 3-12
Part, Poria cocos 4-12 parts, Radix Angelicae Sinensis 1-6 parts, river Chinese herbaceous peony 3-9 parts, Radix Astragali 3-12 parts, almond 1-5 parts, coix seed 2-10 parts, fruit of summer cypress 1-5
Part, root bark of shaggy-fruited dittany 1-5 parts, radix glycyrrhizae 1-5 parts, peppermint 2-6 parts, it is to boil water three times, be concentrated under reduced pressure to give medicinal extract;
(4) material for respectively obtaining three above step mixes jointly, high-temperature sterilization, stands to normal temperature;
(5) aseptically, black bearberry leaf extract 1-4 parts are added in the material obtained to step (4), are stirred,
Produce.
Present invention also provides the application process of above-mentioned Chinese medicine composition, i.e., described composition adds normal according to common process
Skin care item are made in rule auxiliary material.Wherein described skin care item are face cream, emulsion, mildy wash, essence, toner or facial mask.
Present invention also provides the application process of another above-mentioned Chinese medicine composition, will the composition be applied to prepare
In medicine with whitening effect.
The present invention is beneficial to be had technical effect that:
The present invention is substantially exactly that the conglomeration of a large amount of low concentration chemicals acts on based on Chinese medicine, with toxicology field
Chemicals synergy and low concentration Hormesis mechanism is instruct, with reference to the monarch of China's Traditional Chinese Medicine, minister, the thought helped, made
System, discussion of the Traditional Chinese Medicine for herbal function is combined with modern science to the achievement in research of traditional Chinese medicine ingredients, it is selected suitable
With Chinese herbal medicine, scientific compatibility is carried out with different component Hormesis highest effective concentration, then helped with modern times extraction and microorganism
Fermentation technique, the new Chinese medicine preparation with freckle removing and whitening effect is made.
Ginseng is generally well known as " kings of hundred grass " in China's pools of traditional Chinese medicine, the effect of its whitening and softening skin.It has
The activity of stronger suppression tyrosinase, can be with brightening, dispelling spots, dispelling.Meanwhile Ginseng extract does not have any pessimal stimulation to skin,
Also it is highly resistant to cholesterol, helps metabolism, promote skin blood circulation, strengthen skin-nourishing, prevents skin dehydration, hard
Change, corrugation, so as to keep the moisture in keratoderma, make the soft high resilience of skin.
Ganoderma lucidum is always treated as " celestial grass " from ancient times to the present.It can keep and adjust moisture of skin, recover skin elasticity, make skin
Skin moistening, exquisiteness, and formation and the precipitation of the melanin in skin can be suppressed, remove color spot, make hair increase gloss and other effects;
Meanwhile GL-B has significant plan SOD activity, can dramatically free radical caused by removing body, prevents the peroxidating of fat body, protects
Cell has been protected, has been the upstart in improving looks therefore.
Matsutake extract solution has the biological chemical performance for suppressing skin surface melanin.Meanwhile matsutake contained therein is more
Sugar can promote the removing of body free radical, increase antioxidant ability of organism, have obvious effect to radiogenic immunologic mjury
Fruit.
Black bearberry leaf extract mainly contains ursin this natural active matter, it collect " green plants, safe and reliable " and
" efficient decolorizing " three conjunction is humorous to be unified in integral depigmentation of skin component, can rapidly permeate into skin, and not influenceing, cell propagation is dense
While spending, it can effectively suppress the activity of the tyrosinase in skin, block the formation of melanin, pass through itself and junket ammonia enzyme
Directly in conjunction with accelerating the decomposition and excretion of melanin, so as to reduce Skin pigmentation, dispelling stain and freckle, and to black
Chromatophore does not produce the side effects such as toxic, excitant, sensitization, while also has sterilization, the effect of anti-inflammatory.
Present invention accomplishes at present for the needs of natural traditional Chinese medicine whitening composition, positive effect, and have higher safety
Property, it is nontoxic to human body skin non-stimulated.Meanwhile the active component in plurality of Chinese source is combined with each other, solve each activity
The various stability problems that composition is likely to occur when mixing, such as light are stable, thermostabilization, overcome various composition in performance, effect
Influence each other;Most scientific mixing ratio also is found by various tests simultaneously, excellent effect is generated, reaches freckle removing and whitening work(
Effect.
Heretofore described each component is arranged in pairs or groups according to special ratios, and the multiple efficacies composition being rich in reconciles mutually collaboration
And play maximum effect, it is possible to reduce melanin generates and has significant inhibitory action to tyrosinase, has excellent U.S.
White effect and freckle effect, meet that numerous people pursues beautiful hope and demand.
Embodiment
With reference to embodiment, the present invention is specifically described.
Embodiment 1:
The present embodiment prepare with freckle removing and whitening effect Chinese medicine composition used in raw material be:9 parts of ganoderma lucidum, matsutake 18
Part, 6 parts of ginseng, 2 parts of black bearberry leaf extract, 6 parts of sealwort, 6 parts of the bighead atractylodes rhizome, 3 parts of the bletilla striata, 6 parts of the root of herbaceous peony, 6 parts of radix ampelopsis, 6 parts of the larva of a silkworm with batrytis,
8 parts of Poria cocos, 3 parts of Radix Angelicae Sinensis, 6 parts of river Chinese herbaceous peony, 6 parts of the Radix Astragali, 2 parts of almond, 5 parts of coix seed, 1 part of the fruit of summer cypress, 1 part of the root bark of shaggy-fruited dittany, radix glycyrrhizae 2
Part, 3 parts of peppermint.
The preparation method of Chinese medicine composition described in the present embodiment comprises the following steps:
(1) tunning of ganoderma lucidum and matsutake:Ganoderma lucidum and matsutake are weighed, after being milled to powder, distilled water sterilizing is added, connects
Kind bites Lactobacillus lactis fermentation, and fermentation condition is:At 37 DEG C, MRS formulas, quiescent culture 24h;80 DEG C are concentrated under reduced pressure to give leaching afterwards
Cream.
(2) ginseng purification whitening material:Ginseng is weighed, is milled to powder, deionized water, decocting are added by solid-liquid ratio 1: 10
Boil 3 times, each 2h;Merge extract solution, 4500r/min centrifugation 10min, collect supernatant, concentration, 80 DEG C of vacuum drying, obtain
Dried powder be ginseng skin-whitening crude extract;
(3) sealwort, the bighead atractylodes rhizome, the bletilla striata, the root of herbaceous peony, radix ampelopsis, the larva of a silkworm with batrytis, Poria cocos, Radix Angelicae Sinensis, river Chinese herbaceous peony, the Radix Astragali, almond, coix seed,
Skin, the root bark of shaggy-fruited dittany, radix glycyrrhizae, peppermint, it is to boil water three times, be concentrated under reduced pressure to give medicinal extract;
(4) material for respectively obtaining three above step mixes jointly, high-temperature sterilization, stands to normal temperature;
(5) aseptically, black bearberry leaf extract is added in the material obtained to step (4), stirs, produces.
Embodiment 2:
The present embodiment prepare with freckle removing and whitening effect Chinese medicine composition used in raw material be:4 parts of ganoderma lucidum, matsutake 36
Part, 3 parts of ginseng, 1 part of black bearberry leaf extract, 6 parts of sealwort, 6 parts of the bighead atractylodes rhizome, 3 parts of the bletilla striata, 6 parts of the root of herbaceous peony, 6 parts of radix ampelopsis, 6 parts of the larva of a silkworm with batrytis,
8 parts of Poria cocos, 3 parts of Radix Angelicae Sinensis, 6 parts of river Chinese herbaceous peony, 6 parts of the Radix Astragali, 5 parts of almond, 5 parts of coix seed, 1 part of the fruit of summer cypress, 2 parts of the root bark of shaggy-fruited dittany, radix glycyrrhizae 2
Part, 2 parts of peppermint.The preparation method of the Chinese medicine composition is the same as embodiment 1.
Embodiment 3:
The present embodiment prepare with freckle removing and whitening effect Chinese medicine composition used in raw material be:9 parts of ganoderma lucidum, matsutake 18
Part, 6 parts of ginseng, 4 parts of black bearberry leaf extract, 12 parts of sealwort, 12 parts of the bighead atractylodes rhizome, 6 parts of the bletilla striata, 12 parts of the root of herbaceous peony, 12 parts of radix ampelopsis, the larva of a silkworm with batrytis
12 parts, 8 parts of Poria cocos, 3 parts of Radix Angelicae Sinensis, 6 parts of river Chinese herbaceous peony, 12 parts of the Radix Astragali, 2 parts of almond, 5 parts of coix seed, 2 parts of the fruit of summer cypress, 1 part of the root bark of shaggy-fruited dittany,
1 part of radix glycyrrhizae, 4 parts of peppermint.The preparation method of the Chinese medicine composition is the same as embodiment 1.
Embodiment 4:
The present embodiment prepare with freckle removing and whitening effect Chinese medicine composition used in raw material be:18 parts of ganoderma lucidum, matsutake 18
Part, 6 parts of ginseng, 1 part of black bearberry leaf extract, 6 parts of sealwort, 6 parts of the bighead atractylodes rhizome, 3 parts of the bletilla striata, 3 parts of the root of herbaceous peony, 3 parts of radix ampelopsis, 6 parts of the larva of a silkworm with batrytis,
4 parts of Poria cocos, 1 part of Radix Angelicae Sinensis, 3 parts of river Chinese herbaceous peony, 3 parts of the Radix Astragali, 1 part of almond, 2 parts of coix seed, 5 parts of the fruit of summer cypress, 5 parts of the root bark of shaggy-fruited dittany, radix glycyrrhizae 5
Part, 6 parts of peppermint.The preparation method of the Chinese medicine composition is the same as embodiment 1.
Embodiment 5:
The present embodiment prepare with freckle removing and whitening effect Chinese medicine composition used in raw material be:9 parts of ganoderma lucidum, matsutake 18
Part, 12 parts of ginseng, 2 parts of black bearberry leaf extract, 3 parts of sealwort, 3 parts of the bighead atractylodes rhizome, 1 part of the bletilla striata, 3 parts of the root of herbaceous peony, 3 parts of radix ampelopsis, the larva of a silkworm with batrytis 3
Part, 12 parts of Poria cocos, 6 parts of Radix Angelicae Sinensis, 9 parts of river Chinese herbaceous peony, 12 parts of the Radix Astragali, 5 parts of almond, 10 parts of coix seed, 2 parts of the fruit of summer cypress, 5 parts of the root bark of shaggy-fruited dittany,
1 part of radix glycyrrhizae, 6 parts of peppermint.The preparation method of the Chinese medicine composition is the same as embodiment 1.
Test case 1:Toxic side effect is tested
Small white mouse 100 is chosen, body weight 20-25g, male and female have both, and are divided into 10 groups, wherein five groups are embodiment 1-
5 normal amount experimental group (0.05g), the another five groups super quantity experimental groups (0.20g) for embodiment 1-5.Using being applied to
The mouse skin position of hair, smear once sooner or later daily, it is continuous to smear 180 days, mouse reaction is observed daily.As a result show:Respectively
Group mouse behavior is without exception, and no poisoning symptom, appetite, excrement are without exception, and general signs are good, shows that the nti-freckle of the present invention is beautiful
The Chinese medicine preparation of contour painting effect is safe and free of toxic and side effects.
Test case 2:Influence to the inhibitory action of tyrosinase
1st, reagent:The Dopa of L mono- (250MG of Sigma companies 333,786 1);Mushroom Tyrosinase (sigma company's Ts 3,824 1
25KU);Other reagents are that commercially available analysis is pure.
2nd, instrument:The type ultraviolet specrophotometers of Shimadzu UV 1, Shanghai Precision Scientific Apparatus Co., Ltd JA21001 electricity
Sub- balance, ROSH FRQ-1006HT Ultrasound Instruments, the K-type thermostat water baths of SY21 mono-, the upper triumphant experimental instruments and equipment limited DF- of Neptunian satellite
101S heat collecting type constant-temperature heating magnetic stirring apparatus, micropipettor.
3rd, preparation of reagents:
Phosphate buffer solution (PBS):0.2mol/L potassium dihydrogen phosphate 250ml are taken, add 0.2mol/L sodium hydroxides
Solution 118ml, is diluted with water to I000ml, shakes up, and produces.
Tyrosinase solution:Face the used time to be prepared with PBS (pH6.83), concentration 10u/ml;The Dopa solution of L mono-:Face used time use
PBS (pH6.83) is prepared, mass fraction 0.05%;
Sample solution:The composition of embodiment 1 one 5 respectively face the used time with PBS (pH6.83) prepare, be configured to 100mg/
ml。
4th, the measure of tyrosinase activity
Before measure, accurately prepared with micropipettor:
A1 test specimens:2mlPBS+1ml tyrosinase solutions;
A2 test specimens:3mlPBs;
A3 test specimens:1ml sample solution+1mlPBS+1ml tyrosinase solutions;
A4 test specimens:1ml sample solutions+2mlPBS.
Every group sets parallel 2 groups of test tubes, first puts to be incubated after 10min in 25 DEG C of water-baths and adds the Dopa solution of L mono- respectively immediately
1ml, mix.Absorbance is surveyed at 475nm immediately with 25 DEG C of constant temperature water bath reaction 2min.
Inhibitory activity against tyrosinase (%)=[(A2 of A1 mono-) one (A4 of A3 mono-))/(A2 of A1 mono-) * 100
Wherein:A1 does not add the enzyme-added mixed liquor of the present composition.
A2 does not add the liquid of the present composition and enzyme.
A3 adds the mixed liquor of the present composition and enzyme.
A4 adds the present composition and not enzyme-added mixed liquor.
5th, result and analysis
It is repeated 3 times by every group of above-mentioned experimental method is parallel, OD value additions are averaged.Based on tyrosinase inhibition rate formula
Calculate, the results are shown in Table 1.
1 pharmaceutical composition of the present invention of table to tyrosinase activity rejection ratio compared with
Group | Inhibiting rate % |
Vc control groups | 52.22±2.31 |
Embodiment 1 | 78.23±3.08 |
Embodiment 2 | 56.14±1.88 |
Embodiment 3 | 65.25±2.24 |
Embodiment 4 | 59.65±2.36 |
Embodiment 5 | 67.74±1.58 |
In this experimental result, the present composition can suppress tyrosinase activity, play whitening function.
Test case 3:Whitening spot-removing is tested
Inventor to hundreds volunteer by using and observing invention, the Chinese medicine of freckle removing and whitening of the invention in recent years
Formula has good nti-freckle, whitening effect.Especially for the chloasma of female face, its removal effect is good, uses one month
Chloasma substantially mitigates afterwards, is almost wholly absent using chloasma after three months, and its totally nontoxic side effect, to suffering from
The body of person will not damage.
Meanwhile the present invention be discontinued after trimestral return visit, it is found that composition of medicine whitening spot-removing of the present invention effect is not anti-
Bullet, show efficacy stability.Cause whitening spot-removing because of pursuing high tyrosinase activity to suppress in view of some existing products
Effect bounce-back is severe.Therefore, composition of medicine of the present invention does not pursue merely high tyrosinase activity and suppresses that (table 1, embodiment 1 are
78.23 ± 3.08%), but consider tyrosinase activity and suppress and do not rebound, it is determined that nti-freckle product preferably.
It is described above, only it is the preferable case study on implementation of the present invention, any formal limitation not is done to the present invention,
Therefore all contents without departing from technical solution of the present invention, any letter that the technical spirit according to the present invention is done to above case study on implementation
Single modification, equivalent variations and modification, in the range of still falling within technical solution of the present invention.
Claims (5)
1. a kind of Chinese medicine composition with freckle removing and whitening effect, it is characterised in that be made up of the raw material of following parts by weight:
Ganoderma lucidum 4-18 parts, matsutake 9-36 parts, ginseng 3-12 parts, black bearberry leaf extract 1-4 parts, sealwort 3-12 parts, bighead atractylodes rhizome 3-12 parts,
Bletilla striata 1-6 parts, root of herbaceous peony 3-12 parts, radix ampelopsis 3-12 parts, larva of a silkworm with batrytis 3-12 parts, Poria cocos 4-12 parts, Radix Angelicae Sinensis 1-6 parts, river Chinese herbaceous peony 3-9 parts,
Radix Astragali 3-12 parts, almond 1-5 parts, coix seed 2-10 parts, fruit of summer cypress 1-5 parts, root bark of shaggy-fruited dittany 1-5 parts, radix glycyrrhizae 1-5 parts, peppermint 2-6
Part.
A kind of 2. preparation method of the Chinese medicine composition described in claim 1, it is characterised in that:Methods described includes following step
Suddenly:
(1) tunning of ganoderma lucidum and matsutake:4-18 parts ganoderma lucidum and 9-36 part matsutakes are weighed, after being milled to powder, adds distillation
Water is sterilized, and Lactobacillus lactis fermentation is bitten in inoculation, and fermentation condition is:At 37 DEG C, MRS formulas, quiescent culture 24h;80 DEG C of decompressions afterwards
It is concentrated to give medicinal extract.
(2) ginseng purification whitening material:3-12 part ginsengs are weighed, are milled to powder, deionized water, water are added by solid-liquid ratio 1: 10
Decoct 3 times, each 2h;Merge extract solution, 4500r/min centrifugation 10min, collect supernatant, concentration, 80 DEG C of vacuum drying, obtain
To dried powder be ginseng skin-whitening crude extract;
(3) sealwort 3-12 parts, bighead atractylodes rhizome 3-12 parts, bletilla striata 1-6 parts, root of herbaceous peony 3-12 parts, radix ampelopsis 3-12 parts, larva of a silkworm with batrytis 3-12 parts, Fu
It is Siberian cocklebur 4-12 parts, Radix Angelicae Sinensis 1-6 parts, river Chinese herbaceous peony 3-9 parts, Radix Astragali 3-12 parts, almond 1-5 parts, coix seed 2-10 parts, fruit of summer cypress 1-5 parts, white
Fresh hide 1-5 parts, radix glycyrrhizae 1-5 parts, peppermint 2-6 parts, it is to boil water three times, be concentrated under reduced pressure to give medicinal extract;
(4) material for respectively obtaining three above step mixes jointly, high-temperature sterilization, stands to normal temperature;
(5) aseptically, black bearberry leaf extract 1-4 parts are added in the material obtained to step (4), stirs, produces.
3. the application process of the Chinese medicine composition described in a kind of claim 1 or 2, it is characterised in that the composition is according to routine
Technique adds customary adjuvant and skin care item is made.
4. the application process of Chinese medicine composition according to claim 3, it is characterised in that the skin care item are face cream, breast
Liquid, mildy wash, essence, toner or facial mask.
5. the application process of the Chinese medicine composition described in a kind of claim 1 or 2, it is characterised in that the composition is applied to system
In the standby medicine with whitening effect.
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