CN107737272A - A kind of Chinese medicine composition and its methods for making and using same with freckle removing and whitening effect - Google Patents

A kind of Chinese medicine composition and its methods for making and using same with freckle removing and whitening effect Download PDF

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CN107737272A
CN107737272A CN201711257084.7A CN201711257084A CN107737272A CN 107737272 A CN107737272 A CN 107737272A CN 201711257084 A CN201711257084 A CN 201711257084A CN 107737272 A CN107737272 A CN 107737272A
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parts
chinese medicine
radix
medicine composition
whitening
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林志芬
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Tongji University
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Tongji University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/8969—Polygonatum (Solomon's seal)
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    • A61K36/898—Orchidaceae (Orchid family)
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    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A—HUMAN NECESSITIES
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    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract

The invention discloses a kind of Chinese medicine preparation with freckle removing and whitening effect and preparation method thereof, belong to health nursing product technical field.The Chinese medicine preparation includes following raw material：4 18 parts of ganoderma lucidum, 9 36 parts of matsutake, 3 12 parts of ginseng, 14 parts of black bearberry leaf extract, 3 12 parts of sealwort, 3 12 parts of the bighead atractylodes rhizome, 16 parts of the bletilla striata, 3 12 parts of the root of herbaceous peony, 3 12 parts of radix ampelopsis, 3 12 parts of the larva of a silkworm with batrytis, 4 12 parts of Poria cocos, 16 parts of Radix Angelicae Sinensis, 39 parts of river Chinese herbaceous peony, 3 12 parts of the Radix Astragali, 15 parts of almond, 2 10 parts of coix seed, 15 parts of the fruit of summer cypress, 15 parts of the root bark of shaggy-fruited dittany, 15 parts of radix glycyrrhizae, 26 parts of peppermint.Whitening spot-removing skin care item provided by the invention do not stimulate gently, are applicable to sensitive skin crowd, easy to use, natural without any side effects, have good application prospect.

Description

A kind of Chinese medicine composition and its methods for making and using same with freckle removing and whitening effect
Technical field
The present invention relates to belonging to health nursing product technical field, more particularly, to a kind of with freckle removing and whitening effect Chinese medicine composition and its methods for making and using same.
Background technology
Melanin is present in the basal layer of epidermis iuntercellular of people.Skin Bai Bubai, it is black to depend primarily on melanocyte synthesis The ability of pigment.Melanin generates much, and skin is more black；Conversely, then skin is more fair.Ultraviolet irradiation can make black Element produces change, generates a kind of material for protecting skin, and moving layer by layer via cell metabolism, has arrived skin epidermis, from And form that seen color spot, the colour of skin be irregular, the skin problem such as dark yellow.In female face pigmentation, tarnish, dark yellow etc. The most commonly seen skin of face problem of the young women especially age working women, influences mood and the life of young and middle-aged women It is living.
Tyrosinase is currently the only known enzyme in melanin metabolism.In the basal layer of epidermis iuntercellular of people, it is dispersed with black Oxidizing tyrosine can be passed through a series of metabolic process again by chromatophore, the junket ammonia enzyme that it contains into polysaccharide, centre, finally Melanin can be generated.Junket ammonia enzyme has played very important role during caused by melanin.Tyrosinase activity increases Add, caused melanin will be more；Tyrosinase activity is suppressed, and the ability that melanocyte produces melanin just accordingly drops It is low.It may be said that tyrosinase is exactly the key for controlling melanocyte activity, it determines the speed of B16 cell.Tyrosine Enzymatic activity strengthens or pigment disorders, such as chloasma will occur for disorder.
Traditional skin-lightening cosmetic often uses chemical substance, such as hydrogen peroxide, ammoniated mercury and various phenols Derivative, these compounds can be such that melanin tissue disintegrates rapidly, the effect of reaching quick whitening.But because it corrodes to skin Property, the factor such as cytotoxicity and anaphylaxis, have it is greatly dangerous, it is disabled in many national hygienic practices.
Natural traditional Chinese medicine whitening composition sensitization rate is low, it is safe, have broad application prospects, as consumer is in natural Medicine product is advocated, and people's Chinese medicine class skin-lightening cosmetic safe and effective, non-stimulated to those, which seems, particularly to be favored, therefore, from The whitening active ingredients found in Chinese medicine efficiently, less toxic have been increasingly becoming the study hotspot of health nursing product technical field One of.
But Chinese medicine cosmetic species is various at present, it is seldom really to form the prescription of monarch compatibility, Chinese medicine restriction or checking relation in five elements Principle also cause many Chinese medicine materials cannot function as skin care item use.Even if it is according to " the monarch and his subjects help to have part Chinese medicine cosmetic Make " thinking of making up a prescription, according to pharmacopeia recommended dose scope, the use for determining each taste Chinese medicine in prescription is integrated with reference to doctor personal experience Amount, but this " dosage determination " based on experiential basis so that Chinese medicine cosmetic lacks the theoretical direction of science and effect is beaten greatly Discount.
The content of the invention
In view of the above-mentioned problems existing in the prior art, this application provides.Whitening spot-removing skin care product temperature provided by the invention Do not stimulate, be applicable to sensitive skin crowd, it is easy to use, natural without any side effects, there is good application prospect.
Technical scheme is as follows：
A kind of Chinese medicine composition with freckle removing and whitening effect, is made up of the raw material of following parts by weight：
Ganoderma lucidum 4-18 parts, matsutake 9-36 parts, ginseng 3-12 parts, black bearberry leaf extract 1-4 parts, sealwort 3-12 parts, bighead atractylodes rhizome 3- 12 parts, bletilla striata 1-6 parts, root of herbaceous peony 3-12 parts, radix ampelopsis 3-12 parts, larva of a silkworm with batrytis 3-12 parts, Poria cocos 4-12 parts, Radix Angelicae Sinensis 1-6 parts, river Chinese herbaceous peony 3- 9 parts, Radix Astragali 3-12 parts, almond 1-5 parts, coix seed 2-10 parts, fruit of summer cypress 1-5 parts, root bark of shaggy-fruited dittany 1-5 parts, radix glycyrrhizae 1-5 parts, peppermint 2-6 parts.
Present invention also provides the preparation method of above-mentioned Chinese medicine composition, the described method comprises the following steps：
(1) tunning of ganoderma lucidum and matsutake：4-18 parts ganoderma lucidum and 9-36 part matsutakes are weighed, after being milled to powder, is added Distilled water is sterilized, and Lactobacillus lactis fermentation is bitten in inoculation, and fermentation condition is：At 37 DEG C, MRS formulas, quiescent culture 24h；80 DEG C afterwards It is concentrated under reduced pressure to give medicinal extract.
(2) ginseng purification whitening material：3-12 part ginsengs are weighed, are milled to powder, deionization is added by solid-liquid ratio 1: 10 Water, decocting are boiled 3 times, each 2h；Merge extract solution, 4500r/min centrifugation 10min, collect supernatant, concentration, 80 DEG C of vacuum are done Dry, obtained dried powder is ginseng skin-whitening crude extract；
(3) sealwort 3-12 parts, bighead atractylodes rhizome 3-12 parts, bletilla striata 1-6 parts, root of herbaceous peony 3-12 parts, radix ampelopsis 3-12 parts, larva of a silkworm with batrytis 3-12 Part, Poria cocos 4-12 parts, Radix Angelicae Sinensis 1-6 parts, river Chinese herbaceous peony 3-9 parts, Radix Astragali 3-12 parts, almond 1-5 parts, coix seed 2-10 parts, fruit of summer cypress 1-5 Part, root bark of shaggy-fruited dittany 1-5 parts, radix glycyrrhizae 1-5 parts, peppermint 2-6 parts, it is to boil water three times, be concentrated under reduced pressure to give medicinal extract；
(4) material for respectively obtaining three above step mixes jointly, high-temperature sterilization, stands to normal temperature；
(5) aseptically, black bearberry leaf extract 1-4 parts are added in the material obtained to step (4), are stirred, Produce.
Present invention also provides the application process of above-mentioned Chinese medicine composition, i.e., described composition adds normal according to common process Skin care item are made in rule auxiliary material.Wherein described skin care item are face cream, emulsion, mildy wash, essence, toner or facial mask.
Present invention also provides the application process of another above-mentioned Chinese medicine composition, will the composition be applied to prepare In medicine with whitening effect.
The present invention is beneficial to be had technical effect that：
The present invention is substantially exactly that the conglomeration of a large amount of low concentration chemicals acts on based on Chinese medicine, with toxicology field Chemicals synergy and low concentration Hormesis mechanism is instruct, with reference to the monarch of China's Traditional Chinese Medicine, minister, the thought helped, made System, discussion of the Traditional Chinese Medicine for herbal function is combined with modern science to the achievement in research of traditional Chinese medicine ingredients, it is selected suitable With Chinese herbal medicine, scientific compatibility is carried out with different component Hormesis highest effective concentration, then helped with modern times extraction and microorganism Fermentation technique, the new Chinese medicine preparation with freckle removing and whitening effect is made.
Ginseng is generally well known as " kings of hundred grass " in China's pools of traditional Chinese medicine, the effect of its whitening and softening skin.It has The activity of stronger suppression tyrosinase, can be with brightening, dispelling spots, dispelling.Meanwhile Ginseng extract does not have any pessimal stimulation to skin, Also it is highly resistant to cholesterol, helps metabolism, promote skin blood circulation, strengthen skin-nourishing, prevents skin dehydration, hard Change, corrugation, so as to keep the moisture in keratoderma, make the soft high resilience of skin.
Ganoderma lucidum is always treated as " celestial grass " from ancient times to the present.It can keep and adjust moisture of skin, recover skin elasticity, make skin Skin moistening, exquisiteness, and formation and the precipitation of the melanin in skin can be suppressed, remove color spot, make hair increase gloss and other effects； Meanwhile GL-B has significant plan SOD activity, can dramatically free radical caused by removing body, prevents the peroxidating of fat body, protects Cell has been protected, has been the upstart in improving looks therefore.
Matsutake extract solution has the biological chemical performance for suppressing skin surface melanin.Meanwhile matsutake contained therein is more Sugar can promote the removing of body free radical, increase antioxidant ability of organism, have obvious effect to radiogenic immunologic mjury Fruit.
Black bearberry leaf extract mainly contains ursin this natural active matter, it collect " green plants, safe and reliable " and " efficient decolorizing " three conjunction is humorous to be unified in integral depigmentation of skin component, can rapidly permeate into skin, and not influenceing, cell propagation is dense While spending, it can effectively suppress the activity of the tyrosinase in skin, block the formation of melanin, pass through itself and junket ammonia enzyme Directly in conjunction with accelerating the decomposition and excretion of melanin, so as to reduce Skin pigmentation, dispelling stain and freckle, and to black Chromatophore does not produce the side effects such as toxic, excitant, sensitization, while also has sterilization, the effect of anti-inflammatory.
Present invention accomplishes at present for the needs of natural traditional Chinese medicine whitening composition, positive effect, and have higher safety Property, it is nontoxic to human body skin non-stimulated.Meanwhile the active component in plurality of Chinese source is combined with each other, solve each activity The various stability problems that composition is likely to occur when mixing, such as light are stable, thermostabilization, overcome various composition in performance, effect Influence each other；Most scientific mixing ratio also is found by various tests simultaneously, excellent effect is generated, reaches freckle removing and whitening work( Effect.
Heretofore described each component is arranged in pairs or groups according to special ratios, and the multiple efficacies composition being rich in reconciles mutually collaboration And play maximum effect, it is possible to reduce melanin generates and has significant inhibitory action to tyrosinase, has excellent U.S. White effect and freckle effect, meet that numerous people pursues beautiful hope and demand.
Embodiment
With reference to embodiment, the present invention is specifically described.
Embodiment 1：
The present embodiment prepare with freckle removing and whitening effect Chinese medicine composition used in raw material be：9 parts of ganoderma lucidum, matsutake 18 Part, 6 parts of ginseng, 2 parts of black bearberry leaf extract, 6 parts of sealwort, 6 parts of the bighead atractylodes rhizome, 3 parts of the bletilla striata, 6 parts of the root of herbaceous peony, 6 parts of radix ampelopsis, 6 parts of the larva of a silkworm with batrytis, 8 parts of Poria cocos, 3 parts of Radix Angelicae Sinensis, 6 parts of river Chinese herbaceous peony, 6 parts of the Radix Astragali, 2 parts of almond, 5 parts of coix seed, 1 part of the fruit of summer cypress, 1 part of the root bark of shaggy-fruited dittany, radix glycyrrhizae 2 Part, 3 parts of peppermint.
The preparation method of Chinese medicine composition described in the present embodiment comprises the following steps：
(1) tunning of ganoderma lucidum and matsutake：Ganoderma lucidum and matsutake are weighed, after being milled to powder, distilled water sterilizing is added, connects Kind bites Lactobacillus lactis fermentation, and fermentation condition is：At 37 DEG C, MRS formulas, quiescent culture 24h；80 DEG C are concentrated under reduced pressure to give leaching afterwards Cream.
(2) ginseng purification whitening material：Ginseng is weighed, is milled to powder, deionized water, decocting are added by solid-liquid ratio 1: 10 Boil 3 times, each 2h；Merge extract solution, 4500r/min centrifugation 10min, collect supernatant, concentration, 80 DEG C of vacuum drying, obtain Dried powder be ginseng skin-whitening crude extract；
(3) sealwort, the bighead atractylodes rhizome, the bletilla striata, the root of herbaceous peony, radix ampelopsis, the larva of a silkworm with batrytis, Poria cocos, Radix Angelicae Sinensis, river Chinese herbaceous peony, the Radix Astragali, almond, coix seed, Skin, the root bark of shaggy-fruited dittany, radix glycyrrhizae, peppermint, it is to boil water three times, be concentrated under reduced pressure to give medicinal extract；
(4) material for respectively obtaining three above step mixes jointly, high-temperature sterilization, stands to normal temperature；
(5) aseptically, black bearberry leaf extract is added in the material obtained to step (4), stirs, produces.
Embodiment 2：
The present embodiment prepare with freckle removing and whitening effect Chinese medicine composition used in raw material be：4 parts of ganoderma lucidum, matsutake 36 Part, 3 parts of ginseng, 1 part of black bearberry leaf extract, 6 parts of sealwort, 6 parts of the bighead atractylodes rhizome, 3 parts of the bletilla striata, 6 parts of the root of herbaceous peony, 6 parts of radix ampelopsis, 6 parts of the larva of a silkworm with batrytis, 8 parts of Poria cocos, 3 parts of Radix Angelicae Sinensis, 6 parts of river Chinese herbaceous peony, 6 parts of the Radix Astragali, 5 parts of almond, 5 parts of coix seed, 1 part of the fruit of summer cypress, 2 parts of the root bark of shaggy-fruited dittany, radix glycyrrhizae 2 Part, 2 parts of peppermint.The preparation method of the Chinese medicine composition is the same as embodiment 1.
Embodiment 3：
The present embodiment prepare with freckle removing and whitening effect Chinese medicine composition used in raw material be：9 parts of ganoderma lucidum, matsutake 18 Part, 6 parts of ginseng, 4 parts of black bearberry leaf extract, 12 parts of sealwort, 12 parts of the bighead atractylodes rhizome, 6 parts of the bletilla striata, 12 parts of the root of herbaceous peony, 12 parts of radix ampelopsis, the larva of a silkworm with batrytis 12 parts, 8 parts of Poria cocos, 3 parts of Radix Angelicae Sinensis, 6 parts of river Chinese herbaceous peony, 12 parts of the Radix Astragali, 2 parts of almond, 5 parts of coix seed, 2 parts of the fruit of summer cypress, 1 part of the root bark of shaggy-fruited dittany, 1 part of radix glycyrrhizae, 4 parts of peppermint.The preparation method of the Chinese medicine composition is the same as embodiment 1.
Embodiment 4：
The present embodiment prepare with freckle removing and whitening effect Chinese medicine composition used in raw material be：18 parts of ganoderma lucidum, matsutake 18 Part, 6 parts of ginseng, 1 part of black bearberry leaf extract, 6 parts of sealwort, 6 parts of the bighead atractylodes rhizome, 3 parts of the bletilla striata, 3 parts of the root of herbaceous peony, 3 parts of radix ampelopsis, 6 parts of the larva of a silkworm with batrytis, 4 parts of Poria cocos, 1 part of Radix Angelicae Sinensis, 3 parts of river Chinese herbaceous peony, 3 parts of the Radix Astragali, 1 part of almond, 2 parts of coix seed, 5 parts of the fruit of summer cypress, 5 parts of the root bark of shaggy-fruited dittany, radix glycyrrhizae 5 Part, 6 parts of peppermint.The preparation method of the Chinese medicine composition is the same as embodiment 1.
Embodiment 5：
The present embodiment prepare with freckle removing and whitening effect Chinese medicine composition used in raw material be：9 parts of ganoderma lucidum, matsutake 18 Part, 12 parts of ginseng, 2 parts of black bearberry leaf extract, 3 parts of sealwort, 3 parts of the bighead atractylodes rhizome, 1 part of the bletilla striata, 3 parts of the root of herbaceous peony, 3 parts of radix ampelopsis, the larva of a silkworm with batrytis 3 Part, 12 parts of Poria cocos, 6 parts of Radix Angelicae Sinensis, 9 parts of river Chinese herbaceous peony, 12 parts of the Radix Astragali, 5 parts of almond, 10 parts of coix seed, 2 parts of the fruit of summer cypress, 5 parts of the root bark of shaggy-fruited dittany, 1 part of radix glycyrrhizae, 6 parts of peppermint.The preparation method of the Chinese medicine composition is the same as embodiment 1.
Test case 1：Toxic side effect is tested
Small white mouse 100 is chosen, body weight 20-25g, male and female have both, and are divided into 10 groups, wherein five groups are embodiment 1- 5 normal amount experimental group (0.05g), the another five groups super quantity experimental groups (0.20g) for embodiment 1-5.Using being applied to The mouse skin position of hair, smear once sooner or later daily, it is continuous to smear 180 days, mouse reaction is observed daily.As a result show：Respectively Group mouse behavior is without exception, and no poisoning symptom, appetite, excrement are without exception, and general signs are good, shows that the nti-freckle of the present invention is beautiful The Chinese medicine preparation of contour painting effect is safe and free of toxic and side effects.
Test case 2：Influence to the inhibitory action of tyrosinase
1st, reagent：The Dopa of L mono- (250MG of Sigma companies 333,786 1)；Mushroom Tyrosinase (sigma company's Ts 3,824 1 25KU)；Other reagents are that commercially available analysis is pure.
2nd, instrument：The type ultraviolet specrophotometers of Shimadzu UV 1, Shanghai Precision Scientific Apparatus Co., Ltd JA21001 electricity Sub- balance, ROSH FRQ-1006HT Ultrasound Instruments, the K-type thermostat water baths of SY21 mono-, the upper triumphant experimental instruments and equipment limited DF- of Neptunian satellite 101S heat collecting type constant-temperature heating magnetic stirring apparatus, micropipettor.
3rd, preparation of reagents：
Phosphate buffer solution (PBS)：0.2mol/L potassium dihydrogen phosphate 250ml are taken, add 0.2mol/L sodium hydroxides Solution 118ml, is diluted with water to I000ml, shakes up, and produces.
Tyrosinase solution：Face the used time to be prepared with PBS (pH6.83), concentration 10u/ml；The Dopa solution of L mono-：Face used time use PBS (pH6.83) is prepared, mass fraction 0.05%；
Sample solution：The composition of embodiment 1 one 5 respectively face the used time with PBS (pH6.83) prepare, be configured to 100mg/ ml。
4th, the measure of tyrosinase activity
Before measure, accurately prepared with micropipettor：
A1 test specimens：2mlPBS+1ml tyrosinase solutions；
A2 test specimens：3mlPBs；
A3 test specimens：1ml sample solution+1mlPBS+1ml tyrosinase solutions；
A4 test specimens：1ml sample solutions+2mlPBS.
Every group sets parallel 2 groups of test tubes, first puts to be incubated after 10min in 25 DEG C of water-baths and adds the Dopa solution of L mono- respectively immediately 1ml, mix.Absorbance is surveyed at 475nm immediately with 25 DEG C of constant temperature water bath reaction 2min.
Inhibitory activity against tyrosinase (%)=[(A2 of A1 mono-) one (A4 of A3 mono-))/(A2 of A1 mono-) * 100
Wherein：A1 does not add the enzyme-added mixed liquor of the present composition.
A2 does not add the liquid of the present composition and enzyme.
A3 adds the mixed liquor of the present composition and enzyme.
A4 adds the present composition and not enzyme-added mixed liquor.
5th, result and analysis
It is repeated 3 times by every group of above-mentioned experimental method is parallel, OD value additions are averaged.Based on tyrosinase inhibition rate formula Calculate, the results are shown in Table 1.
1 pharmaceutical composition of the present invention of table to tyrosinase activity rejection ratio compared with
Group Inhibiting rate %
Vc control groups 52.22±2.31
Embodiment 1 78.23±3.08
Embodiment 2 56.14±1.88
Embodiment 3 65.25±2.24
Embodiment 4 59.65±2.36
Embodiment 5 67.74±1.58
In this experimental result, the present composition can suppress tyrosinase activity, play whitening function.
Test case 3：Whitening spot-removing is tested
Inventor to hundreds volunteer by using and observing invention, the Chinese medicine of freckle removing and whitening of the invention in recent years Formula has good nti-freckle, whitening effect.Especially for the chloasma of female face, its removal effect is good, uses one month Chloasma substantially mitigates afterwards, is almost wholly absent using chloasma after three months, and its totally nontoxic side effect, to suffering from The body of person will not damage.
Meanwhile the present invention be discontinued after trimestral return visit, it is found that composition of medicine whitening spot-removing of the present invention effect is not anti- Bullet, show efficacy stability.Cause whitening spot-removing because of pursuing high tyrosinase activity to suppress in view of some existing products Effect bounce-back is severe.Therefore, composition of medicine of the present invention does not pursue merely high tyrosinase activity and suppresses that (table 1, embodiment 1 are 78.23 ± 3.08%), but consider tyrosinase activity and suppress and do not rebound, it is determined that nti-freckle product preferably.
It is described above, only it is the preferable case study on implementation of the present invention, any formal limitation not is done to the present invention, Therefore all contents without departing from technical solution of the present invention, any letter that the technical spirit according to the present invention is done to above case study on implementation Single modification, equivalent variations and modification, in the range of still falling within technical solution of the present invention.

Claims (5)

1. a kind of Chinese medicine composition with freckle removing and whitening effect, it is characterised in that be made up of the raw material of following parts by weight：
Ganoderma lucidum 4-18 parts, matsutake 9-36 parts, ginseng 3-12 parts, black bearberry leaf extract 1-4 parts, sealwort 3-12 parts, bighead atractylodes rhizome 3-12 parts, Bletilla striata 1-6 parts, root of herbaceous peony 3-12 parts, radix ampelopsis 3-12 parts, larva of a silkworm with batrytis 3-12 parts, Poria cocos 4-12 parts, Radix Angelicae Sinensis 1-6 parts, river Chinese herbaceous peony 3-9 parts, Radix Astragali 3-12 parts, almond 1-5 parts, coix seed 2-10 parts, fruit of summer cypress 1-5 parts, root bark of shaggy-fruited dittany 1-5 parts, radix glycyrrhizae 1-5 parts, peppermint 2-6 Part.
A kind of 2. preparation method of the Chinese medicine composition described in claim 1, it is characterised in that：Methods described includes following step Suddenly：
(1) tunning of ganoderma lucidum and matsutake：4-18 parts ganoderma lucidum and 9-36 part matsutakes are weighed, after being milled to powder, adds distillation Water is sterilized, and Lactobacillus lactis fermentation is bitten in inoculation, and fermentation condition is：At 37 DEG C, MRS formulas, quiescent culture 24h；80 DEG C of decompressions afterwards It is concentrated to give medicinal extract.
(2) ginseng purification whitening material：3-12 part ginsengs are weighed, are milled to powder, deionized water, water are added by solid-liquid ratio 1: 10 Decoct 3 times, each 2h；Merge extract solution, 4500r/min centrifugation 10min, collect supernatant, concentration, 80 DEG C of vacuum drying, obtain To dried powder be ginseng skin-whitening crude extract；
(3) sealwort 3-12 parts, bighead atractylodes rhizome 3-12 parts, bletilla striata 1-6 parts, root of herbaceous peony 3-12 parts, radix ampelopsis 3-12 parts, larva of a silkworm with batrytis 3-12 parts, Fu It is Siberian cocklebur 4-12 parts, Radix Angelicae Sinensis 1-6 parts, river Chinese herbaceous peony 3-9 parts, Radix Astragali 3-12 parts, almond 1-5 parts, coix seed 2-10 parts, fruit of summer cypress 1-5 parts, white Fresh hide 1-5 parts, radix glycyrrhizae 1-5 parts, peppermint 2-6 parts, it is to boil water three times, be concentrated under reduced pressure to give medicinal extract；
(4) material for respectively obtaining three above step mixes jointly, high-temperature sterilization, stands to normal temperature；
(5) aseptically, black bearberry leaf extract 1-4 parts are added in the material obtained to step (4), stirs, produces.
3. the application process of the Chinese medicine composition described in a kind of claim 1 or 2, it is characterised in that the composition is according to routine Technique adds customary adjuvant and skin care item is made.
4. the application process of Chinese medicine composition according to claim 3, it is characterised in that the skin care item are face cream, breast Liquid, mildy wash, essence, toner or facial mask.
5. the application process of the Chinese medicine composition described in a kind of claim 1 or 2, it is characterised in that the composition is applied to system In the standby medicine with whitening effect.
CN201711257084.7A 2017-12-03 2017-12-03 A kind of Chinese medicine composition and its methods for making and using same with freckle removing and whitening effect Pending CN107737272A (en)

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108618975A (en) * 2018-07-03 2018-10-09 崔洪学 A kind of Chinese medicine compound prescription facial masks for whitening faces and removing spots and preparation method thereof
CN109846762A (en) * 2018-09-17 2019-06-07 上海珈凯生物科技有限公司 A kind of composition with white-skinned face function and preparation method thereof, application
CN109846772A (en) * 2018-10-29 2019-06-07 上海珈凯生物科技有限公司 A kind of composition with white-skinned face function, skin care item and preparation method thereof
CN110393693A (en) * 2019-08-27 2019-11-01 万红军 The net skin beauty face-whitening-nourishing facial mask of nti-freckle and preparation method that one Plant Extracts extract
CN110772456A (en) * 2019-11-04 2020-02-11 中国热带农业科学院南亚热带作物研究所 Miracle fruit leaf compound and application thereof in anti-melanin formation product
CN111449985A (en) * 2020-04-09 2020-07-28 株洲千金药业股份有限公司 Fine moistening and repairing wash-free mask and preparation method thereof
CN112316058A (en) * 2020-12-05 2021-02-05 赣州佰珍堂生物科技有限公司 Preparation process of traditional Chinese medicine with whitening and freckle removing functions
CN113171314A (en) * 2021-04-24 2021-07-27 广州市德创生物科技有限公司 Whitening composition and preparation method and application thereof
CN114617803A (en) * 2022-03-22 2022-06-14 王新伟 Pure natural medical mineral water and traditional Chinese medicine composition
CN115006328A (en) * 2022-06-30 2022-09-06 广西下班乐生物科技有限公司 Whitening and freckle-removing composition and preparation method and application thereof
CN115737468A (en) * 2022-11-28 2023-03-07 陕西慧康生物科技有限责任公司 Mild multi-effect repair composition containing propagum germanium and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107224423A (en) * 2017-06-15 2017-10-03 广西南宁博智生物科技有限公司 A kind of hydrosol with whitening function

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107224423A (en) * 2017-06-15 2017-10-03 广西南宁博智生物科技有限公司 A kind of hydrosol with whitening function

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
王建新主编: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 *
赵丹等: "灵芝发酵液的成分检测及美白与抗衰老功效评价", 《日用化学工业》 *
郑爽: "松茸液体发酵产物的美白作用的研究", 《中国优秀硕士学位论文全文数据库 农业科技辑》 *

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CN108618975A (en) * 2018-07-03 2018-10-09 崔洪学 A kind of Chinese medicine compound prescription facial masks for whitening faces and removing spots and preparation method thereof
CN109846762A (en) * 2018-09-17 2019-06-07 上海珈凯生物科技有限公司 A kind of composition with white-skinned face function and preparation method thereof, application
CN109846772A (en) * 2018-10-29 2019-06-07 上海珈凯生物科技有限公司 A kind of composition with white-skinned face function, skin care item and preparation method thereof
CN110393693A (en) * 2019-08-27 2019-11-01 万红军 The net skin beauty face-whitening-nourishing facial mask of nti-freckle and preparation method that one Plant Extracts extract
CN110772456B (en) * 2019-11-04 2022-08-23 中国热带农业科学院南亚热带作物研究所 Miracle fruit leaf compound and application thereof in anti-melanin formation product
CN110772456A (en) * 2019-11-04 2020-02-11 中国热带农业科学院南亚热带作物研究所 Miracle fruit leaf compound and application thereof in anti-melanin formation product
CN111449985A (en) * 2020-04-09 2020-07-28 株洲千金药业股份有限公司 Fine moistening and repairing wash-free mask and preparation method thereof
CN112316058A (en) * 2020-12-05 2021-02-05 赣州佰珍堂生物科技有限公司 Preparation process of traditional Chinese medicine with whitening and freckle removing functions
CN113171314A (en) * 2021-04-24 2021-07-27 广州市德创生物科技有限公司 Whitening composition and preparation method and application thereof
CN114617803A (en) * 2022-03-22 2022-06-14 王新伟 Pure natural medical mineral water and traditional Chinese medicine composition
CN115006328A (en) * 2022-06-30 2022-09-06 广西下班乐生物科技有限公司 Whitening and freckle-removing composition and preparation method and application thereof
CN115006328B (en) * 2022-06-30 2023-10-24 广西下班乐生物科技有限公司 Whitening and freckle-removing composition, and preparation method and application thereof
CN115737468A (en) * 2022-11-28 2023-03-07 陕西慧康生物科技有限责任公司 Mild multi-effect repair composition containing propagum germanium and application thereof

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Application publication date: 20180227