CN101234132A - New use of angelica sinensis or its extract in preparing skin care products - Google Patents
New use of angelica sinensis or its extract in preparing skin care products Download PDFInfo
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- CN101234132A CN101234132A CNA2007100483670A CN200710048367A CN101234132A CN 101234132 A CN101234132 A CN 101234132A CN A2007100483670 A CNA2007100483670 A CN A2007100483670A CN 200710048367 A CN200710048367 A CN 200710048367A CN 101234132 A CN101234132 A CN 101234132A
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Abstract
The invention relates to a use of angelica or an extract thereof in preparing skin care products, which belongs to a field of cosmetics. The angelica or the extract thereof have the advantages of adjusting skin secretion function, moisture keeping function, preventing and curing stains and promoting skin metabolism. The skin care products of the invention adopt the angelica or the extract thereof as main active components, which have remarkable effect on improving the complexion and healthy state of skin and provide a novel skin care selection for the public.
Description
Technical field
The present invention relates to the purposes that Radix Angelicae Sinensis or its extract prepare skin care item, belong to cosmetic field (A61Q).
Background technology
Radix Angelicae Sinensis sweet in the mouth, suffering, warm in nature, for nourshing blood and promoting blood circulation good medicine, to insufficiency of generating and transforming QI and blood, or QI-blood circulation is slow and blood deficiency dryness of the intestine constipation person, and informal dress is imitated good.Since ancient times always as the key medicine for the treatment of gynaecopathia.Shennong's Herbal is said: " housewife people's sterilization that leaks down, all malignant boil infectionss, incised wound." Compendium of Material Medica adds: " control headache, all pains of trusted subordinate.The smooth stomach muscles and bones of Run, skin, control carbuncle, evacuation of pus pain relieving and blood and enrich blood.”
Modern medicine study confirms that the main component of Radix Angelicae Sinensis is totally 80 kinds of chemical substances such as multiple organic acid, esters, sugar, several amino acids, trace element and other organic principle.Radix Angelicae Sinensis volatile oil content reaches 0.45%, is its main component with ligustilide, and content about 45% in oil.
Do not see that as yet Radix Angelicae Sinensis or its extract are applied to the relevant report of skin care item.
Summary of the invention
Technical problem to be solved by this invention provides the new purposes of Radix Angelicae Sinensis or its extract.
Particularly, provide Radix Angelicae Sinensis or its extract purposes in the preparation skin care item.
Described skin care item have the skin of adjusting secretory function, moisture-keeping functions, prophylactic treatment mottle, promote the metabolic effect of the new one-tenth of skin.
Another technical problem to be solved by this invention provides the Radix Angelicae Sinensis extract that can be used for preparing skin care item.
Radix Angelicae Sinensis extract of the present invention is to be raw material with Radix Angelicae Sinensis primary crude drug or section or powder, with 50～100%v/v soak with ethanol or heating extraction, extracts 15～120min, filter, filtrate, promptly get liquid extract; Or, promptly get the solids extraction thing with the filtrate drying; The content of ligustilide is 0.350～0.500% in gained liquid extract or the solids extraction thing, and content of ferulic acid is 0.060～0.075%.
Evidence, Radix Angelicae Sinensis extract of the present invention has the skin of adjusting secretory function, moisture-keeping functions, prevention mottle, promotes the metabolic effect of the new one-tenth of skin, with Radix Angelicae Sinensis or its extract is main active in the skin care item, the colour of skin and the health status that are used to improve skin have tangible effect, select for the public provides a kind of new skin protection.
The specific embodiment
New purposes of the present invention mainly is Radix Angelicae Sinensis or its extract purposes in the preparation skin care item.
Particularly, Radix Angelicae Sinensis or its extract have the excretory function of the skin of adjusting.The physiology protective substance of skin secretion makes that the skin softness is tough and tensile, gloss is attractive in appearance." skin fat " generation " waterproof membrane " that skin secretion forms from the teeth outwards and the physiological function of " moisture film ".After skin is washed, the temporary transient attenuation of sebum film and functional disorder.With the preparation of Radix Angelicae Sinensis or Radix Angelicae Sinensis extract and skin care item be coated on the skin after the cleaning, wherein contained effective ingredient, closely dissolve each other with the physiology skin secretion, " the artificial skin adipose membrane " that forms, not only the physiological function of natural " sebum film " can be replaced fully, but also the various skin maintenance effect that physiology " sebum film " does not possess can be brought into play.
Radix Angelicae Sinensis or its extract have moisture preserving function.With the preparation of Radix Angelicae Sinensis or Radix Angelicae Sinensis extract and skin care item, wherein contained effective ingredient holds behind these effective ingredient of skin absorbs and is contained in the epidermis, makes keratodermatitis keep competent water content, performance " directly preserving moisture " mechanism; Formed " artificial skin adipose membrane ", closed coat, the volatilization of control moisture, " preserving moisture indirectly " function of performance physiology " moisture film ", the coordinative role of the mechanism of directly and indirectly preserving moisture reaches the skin care effect of " stable fully again preserving moisture ".
Radix Angelicae Sinensis or its extract have the function of prophylactic treatment mottle.With the preparation of Radix Angelicae Sinensis or Radix Angelicae Sinensis extract and skin care item, the volatile component that contains has blood circulation promoting and blood stasis dispelling, improves the function of skin microcirculation, life-time service can reach the control mottle, as the effect of senile plaque, chloasma, freckle, sunburn, hydropenia speckle.
Radix Angelicae Sinensis or its extract have the metabolic function of the new one-tenth of the skin of promotion.Can promote the metabolism of skin, improve skin microcirculation, blood circulation promoting and blood stasis dispelling, regulate skin immune function controlling, suppress the generation of dermal melanin, suppress the infringement of radical pair skin, strengthen the skin SOD vigor, reach and prevent skin generation abnormal change, the skin care effect of " keeping the skin ecological balance, the prevention dermatosis ".
Because people's physiology sebum has stronger hydrophobicity, be full of dead bark, the chap skin of physiology sebum, make shipwreck to infiltrate not easy cleaning, with the preparation of Radix Angelicae Sinensis or Radix Angelicae Sinensis extract and the effective ingredient that contains of skin care item can combine with the physiology skin secretion, faint suction is arranged, increase the volume function, dead bark, chap skin are cleaned totally easily.
The present invention is used to prepare the Radix Angelicae Sinensis extract of skin care item, is to be raw material with Radix Angelicae Sinensis primary crude drug or section or powder, with 50～100%v/v soak with ethanol or heating extraction, extracts 15～120min, filter, filtrate, promptly get liquid extract; Or, promptly get the solids extraction thing with the filtrate drying; The content of ligustilide is 0.350～0.500% in gained liquid extract or the solids extraction thing, content of ferulic acid Wei 0.060～0.075%.
Preferably, concentration of alcohol 75%v/v, extraction time 30min.
Below test for the preparation screening technology of Radix Angelicae Sinensis extract of the present invention.
Selection of experiment conditions
1, extracting choice of Solvent is solvent with water and Different concentrations of alcohol, adopts the extracting method of reflux, assay determination, and comparative result sees Table 1.
Accurately take by weighing through pulverizing the Chinese Angelica Root 60g can cross the 0.6mm sieve and place in the three-neck flask, add the solvent of 4200ml, soaks reflux, extract, after 2 hours, boil back maintenance 1h, replenish lost solvent, extracting solution 0.45um membrane filtration promptly gets Radix Angelicae Sinensis extracting solution.Assay determination.
Table 1 extracts choice of Solvent
| Solvent | Water | 50%v/v ethanol | 75%v/v ethanol | 100%v/v ethanol |
| Ligustilide | 0.0781％ | 0.397％ | 0.455％ | 0.455％ |
| Ferulic acid | 0.0694％ | 0.0692％ | 0.0691％ | 0.0688％ |
Proof by experiment can be crossed the Chinese Angelica Root of 0.6mm sieve (i.e. 28 mesh sieves, CP screen size 2～3), selects for use the ethanol of 75%v/v concentration to make the extraction solvent, takes all factors into consideration more excellent from cost and extraction effect.
2, after solvent is determined in the selection of extracting method and time, difference reflux 15,30,60,120min, assay determination, comparative result sees Table 2.
Adopt said method, accurately take by weighing through pulverizing the Chinese Angelica Root 60g that can cross the 0.6mm sieve and place in the three-neck flask, 75% ethanol that adds 4200ml, soak reflux, extract, after 2 hours, difference reflux 15,30,60,120min, replenish lost solvent, extracting solution 0.45um membrane filtration promptly gets Radix Angelicae Sinensis extracting solution.Assay determination.
The selection of table 2 extracting method and time
| Return time (min) | 15 | 30 | 60 | 120 |
| Ligustilide | 0.405％ | 0.455％ | 0.455％ | 0.455％ |
| Ferulic acid | 0.0623％ | 0.0691％ | 0.0691％ | 0.0688％ |
Proof selects for use return time 30min to take all factors into consideration more excellent from cost and extraction effect by experiment.
3, the medical material fineness is determined solvent and extracting method to the influence of the response rate and after the time, is adopted the Radix Angelicae Sinensis powder of lamellar and various different fineness, to the assay determination of gained extracting solution, comparative result.
Adopt the ethanol of 75%v/v concentration, reflux, extract, 30min institute optimized conditions is extracted with Radix Angelicae Sinensis Tabellae, 2500 orders, 10000 order powder respectively, and the result is as follows, sees Table 3:
Table 3 medical material fineness is to the influence of the response rate
| Radix Angelicae Sinensis fineness (solvent) | Radix Angelicae Sinensis Tabellae (75% ethanol) | 2500 order powder (75% ethanol) | 10000 order powder (75% ethanol) | 2500 order powder (water) | 10000 order powder (water) |
| Ligustilide | 0.400％ | 0.450％ | 0.455％ | 0.454％ | 0.455％ |
| Ferulic acid | 0.0601％ | 0.0691％ | 0.0691％ | 0.0690％ | 0.0691％ |
As seen the fineness of medical material has very big influence to extraction effect.The thin more extraction of medical material is complete more, and the Radix Angelicae Sinensis fineness is when reaching 2500 orders, the ligustilide of the extract of water and 75% ethanol extraction gained and ferulaic acid content much at one, so when powder is superfine, select water reasonable more economically as extracting solvent.
Determining of Radix Angelicae Sinensis extraction process: accurately took by weighing through pulverizing 2500 purpose Chinese Angelica Root 360g and place in the three-neck flask, the deionized water that adds 4200ml, soak and use the serpentine condenser reflux, extract, after 2 hours, boil the back and keep 30min, extracting solution 0.45um membrane filtration.
Radix Angelicae Sinensis extract quality standard of the present invention:
1, outward appearance: brown clear liquid; Flavor: bitter sweet; PH value: 5-7; Viscosity (25 ℃ of Pas): 〉=0.2; Solid content: 〉=3% (conventional analysis); Total number of bacteria :≤500/g; Bacillus pyocyaneus: nothing detects.
2, analysis of effective component method: main component ligustilide, ferulic acid adopt immobilized liposome body colour spectrum (inmobilizedliposome chranatography ILC) carry out qualitative, quantitative analysis.Referring to " the permeability of cell membrane composition and the quality control thereof of immobilized liposome body colour spectrum research Chinese medicine compound ".
Radix Angelicae Sinensis extract of the present invention preparation and the clinical speckle dispelling test of skin care item.
Prescription W% W%
Oil phase: (1) (2)
Squalane 11
Isopropyl palmitate 33
Oleyl alcohol 0.5 0.5
Polydimethylsiloxane 11
Vitamin E acetate 0.2 0.2
16 octadecanol 44
Tristerin 0.8 0.8
16 polyoxyethylene octadecanols-20 1.5 1.5
BHT 0.1 0.1
Water:
Glycerol 33
Propylene glycol 22
Arbutin 0.6 0
Sodium sulfite 0.1 0.1
Deionized water to 100 is to 100
Additive:
Radix Angelicae Sinensis liquid extract 04
Methyl hydroxybenzoate/propylparaben 0.1 0.15
Phenyl phenol 0.8 0.8
Essence is an amount of
The test crowd: 25-60 year face suffers from 30 of the women crowds of mottles such as chloasma, freckle, senile plaque.
Test method: under the definite environment and light, face is taken pictures, and (1) (2) number formulation product is respectively smeared half of face with standard method respectively, numbers 1～No. 15 and uses (1) number product, numbers 16～No. 30 and uses (2) number product.Use and took pictures respectively in 15 days, 28 days, statistical result sees Table 4.
The preparation of table 4 Radix Angelicae Sinensis extract of the present invention and the clinical speckle dispelling test of skin care item
| Numbering | Age | The speckle type | 15 days situations | 30 days situations | Have or not abnormal response |
| 1 | 32 | Chloasma | No. 4 standards | No. 8 standards | Do not have |
| 2 | 35 | Freckle | No. 3 standards | No. 7 standards | Do not have |
| 3 | 28 | The hydropenia speckle | No. 6 standards | No. 9 standards | Do not have |
| 4 | 46 | Freckle | No. 3 standards | No. 6 standards | Do not have |
| 5 | 52 | Sunburn | No. 4 standards | No. 7 standards | Do not have |
| 6 | 36 | The hydropenia speckle | No. 5 standards | No. 8 standards | Do not have |
| 7 | 42 | Sunburn | No. 4 standards | No. 9 standards | Do not have |
| 8 | 45 | Sunburn | No. 5 standards | No. 7 standards | Do not have |
| 9 | 39 | The hydropenia speckle | No. 3 standards | No. 6 standards | Do not have |
| 10 | 37 | The hydropenia speckle | No. 5 standards | No. 8 standards | Do not have |
| 11 | 41 | Senile plaque | No. 3 standards | No. 7 standards | Do not have |
| 12 | 55 | Senile plaque | No. 3 standards | No. 8 standards | Do not have |
| 13 | 52 | Senile plaque | No. 5 standards | No. 9 standards | Do not have |
| 14 | 29 | The hydropenia speckle | No. 6 standards | No. 9 standards | Do not have |
| 15 | 26 | Sunburn | No. 4 standards | No. 8 standards | Do not have |
| 16 | 50 | Sunburn | No. 2 standards | No. 7 standards | Do not have |
| 17 | 40 | Sunburn | No. 4 standards | No. 7 standards | Do not have |
| 18 | 39 | Sunburn | No. 5 standards | No. 8 standards | Do not have |
| 19 | 47 | Senile plaque | No. 3 standards | No. 6 standards | Do not have |
| 20 | 55 | Senile plaque | No. 3 standards | No. 6 standards | Do not have |
| 21 | 51 | Senile plaque | No. 2 standards | No. 5 standards | Do not have |
| 22 | 46 | Senile plaque | No. 3 standards | No. 5 standards | Do not have |
| 23 | 44 | Freckle | No. 3 standards | No. 5 standards | Do not have |
| 24 | 33 | The hydropenia speckle | No. 5 standards | No. 7 standards | Do not have |
| 25 | 52 | Senile plaque | No. 2 standards | No. 5 standards | Do not have |
| 26 | 54 | Senile plaque | No. 2 standards | No. 5 standards | Do not have |
| 27 | 36 | The hydropenia speckle | No. 4 standards | No. 7 standards | Do not have |
| 28 | 39 | The hydropenia speckle | No. 5 standards | No. 8 standards | Do not have |
| 29 | 49 | Freckle | No. 4 standards | No. 7 standards | Do not have |
| 30 | 51 | Senile plaque | No. 3 standards | No. 6 standards | Do not have |
The clinical trial conclusion: this clinical trial uses Radix Angelicae Sinensis extract to use as the skin care item of whitening and speckle dispelling, and freckle effect is remarkable, and the mottle area obviously reduces, and color is thin out.Simultaneously Radix Angelicae Sinensis extract also have the skin of adjusting secretory function, moisture-keeping functions,, promote that skin is new and become metabolic effect, select for the public provides a kind of new skin protection.
Claims (8)
1. Radix Angelicae Sinensis or its extract are in the purposes of preparation in the skin care item.
2. purposes according to claim 1 is characterized in that: described skin care item are for regulating the skin care item of skin secretory function.
3. purposes according to claim 1 is characterized in that: described skin care item are the skin care item with moisture-keeping functions.
4. purposes according to claim 1 is characterized in that: described skin care item are the skin care item of prophylactic treatment mottle.
5. purposes according to claim 1 is characterized in that: described skin care item are for promoting the metabolic skin care item of the new one-tenth of skin.
6. can be used for preparing the Radix Angelicae Sinensis extract of skin care item, it is characterized in that: Radix Angelicae Sinensis primary crude drug or section or powder extract 15～120min with 50～100%v/v soak with ethanol or heating extraction, filter, and get filtrate, promptly get liquid extract; Or, promptly get the solids extraction thing with the filtrate drying; The content of ligustilide is 0.350～0.500% in gained liquid extract or the solids extraction thing, and content of ferulic acid is 0.060～0.075%.
7. Radix Angelicae Sinensis extract according to claim 6 is characterized in that: described concentration of alcohol is 75%v/v.
8. Radix Angelicae Sinensis extract according to claim 6 is characterized in that: described extraction time is 30min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100483670A CN101234132A (en) | 2007-01-31 | 2007-01-31 | New use of angelica sinensis or its extract in preparing skin care products |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100483670A CN101234132A (en) | 2007-01-31 | 2007-01-31 | New use of angelica sinensis or its extract in preparing skin care products |
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| CN101234132A true CN101234132A (en) | 2008-08-06 |
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| CNA2007100483670A Pending CN101234132A (en) | 2007-01-31 | 2007-01-31 | New use of angelica sinensis or its extract in preparing skin care products |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104546963A (en) * | 2014-12-26 | 2015-04-29 | 高俊丽 | Method for extracting extract from angelica sinensis |
| CN104606178A (en) * | 2015-02-09 | 2015-05-13 | 李健 | Application of 2-valeryl-1, 5-cyclohexadiene-1-carboxylic acid in preparing medicine for treating chloasma |
| CN106619223A (en) * | 2016-12-28 | 2017-05-10 | 李凌霞 | Natural anti-aging cosmetic and preparation method thereof |
| CN108379314A (en) * | 2018-03-05 | 2018-08-10 | 南通大学 | A kind of Chinese medical extract extracting method |
| CN110403857A (en) * | 2018-04-26 | 2019-11-05 | 王勤华 | A kind of soothing oil |
| CN111840148A (en) * | 2019-04-25 | 2020-10-30 | 珀莱雅化妆品股份有限公司 | Skin care composition with anti-allergy and anti-corrosion effects and preparation method thereof |
| CN114469934A (en) * | 2022-02-11 | 2022-05-13 | 天津中新药业集团股份有限公司第六中药厂 | Composition and pharmaceutical preparation thereof |
-
2007
- 2007-01-31 CN CNA2007100483670A patent/CN101234132A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104546963A (en) * | 2014-12-26 | 2015-04-29 | 高俊丽 | Method for extracting extract from angelica sinensis |
| CN104606178A (en) * | 2015-02-09 | 2015-05-13 | 李健 | Application of 2-valeryl-1, 5-cyclohexadiene-1-carboxylic acid in preparing medicine for treating chloasma |
| CN106619223A (en) * | 2016-12-28 | 2017-05-10 | 李凌霞 | Natural anti-aging cosmetic and preparation method thereof |
| CN106619223B (en) * | 2016-12-28 | 2019-11-29 | 黑龙江中医药大学 | A kind of natural anti-aging cosmetics and preparation method thereof |
| CN108379314A (en) * | 2018-03-05 | 2018-08-10 | 南通大学 | A kind of Chinese medical extract extracting method |
| CN110403857A (en) * | 2018-04-26 | 2019-11-05 | 王勤华 | A kind of soothing oil |
| CN111840148A (en) * | 2019-04-25 | 2020-10-30 | 珀莱雅化妆品股份有限公司 | Skin care composition with anti-allergy and anti-corrosion effects and preparation method thereof |
| CN111840148B (en) * | 2019-04-25 | 2022-01-14 | 珀莱雅化妆品股份有限公司 | Skin care composition with anti-allergy and anti-corrosion effects and preparation method thereof |
| CN114469934A (en) * | 2022-02-11 | 2022-05-13 | 天津中新药业集团股份有限公司第六中药厂 | Composition and pharmaceutical preparation thereof |
| CN114469934B (en) * | 2022-02-11 | 2023-08-25 | 津药达仁堂集团股份有限公司第六中药厂 | Composition and pharmaceutical preparation thereof |
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Open date: 20080806 |