CN107661435A

CN107661435A - A kind of cypress Cape jasmine clearing damp spray and preparation method thereof

Info

Publication number: CN107661435A
Application number: CN201711155708.4A
Authority: CN
Inventors: 葛玲玲
Original assignee: HAOCHENG PHARMACEUTICAL CO Ltd GUAIZHOU
Current assignee: HAOCHENG PHARMACEUTICAL CO Ltd GUAIZHOU
Priority date: 2017-11-20
Filing date: 2017-11-20
Publication date: 2018-02-06

Abstract

The invention provides a kind of cypress Cape jasmine clearing damp spray and preparation method thereof, it is related to technical field of traditional Chinese medicines.Spray is made up of the raw material of following parts by weight meter：10~20 parts of golden cypress, 10~15 parts of the Radix Astragali, 10~15 parts of rheum officinale, 5~10 parts of cape jasmine, 10~15 parts of Sculellaria barbata, 10~20 parts of oldenlandia diffusa, 10~15 parts of honeysuckle, 10~20 parts of glutinous rehmannia, 10~15 parts of cordate houttuynia, 10~15 parts of oriental wormwood, 5~10 parts of small radix bupleuri, 1~5 part of Radix Isatidis, 5~10 parts of Asian puccoon, 1~5 part of scorpio, 5~10 parts of the capsule of weeping forsythia, 1~7 part of the stem pith of the rice-paper plant, 5~8 parts of the fruit of summer cypress, 5~10 parts of talcum, 10~15 parts of the wind-weed and 5~10 parts of radix glycyrrhizae.This spray is effectively directed to various types of colpitis, and therapeutic effect is obvious, short treating period and uneasy to recur.

Description

A kind of cypress Cape jasmine clearing damp spray and preparation method thereof

Technical field

The present invention relates to technical field of traditional Chinese medicines, and more particularly to a kind of cypress Cape jasmine clearing damp spray and preparation method thereof.

Background technology

Vaginitis is women common disease, affects the physical and mental health of women, is somebody's turn to do simultaneously high recurrence rate, office's gynecological infectious diseases First place.Vaginitis includes bacterial vaginitis, trichomonal vaginitis, beads vaginitis, senile vahinitis, viral vagina Scorching, radioactivity vaginitis and aerobic bacteria property vaginitis etc..

At present, vaginitis treatment drug administration approach mainly has oral and two kinds of vagina local application, wherein guiding is local Due to having the characteristics that local drug concentration is high, formulation dosage is low and safe and effective, clinical evaluation is high for medication.It is but existing at present Easily recurred with the presence of the medicine in technology, treat the problems such as type limitation is larger.

The content of the invention

It is an object of the invention to provide a kind of cypress Cape jasmine clearing damp spray, this spray effectively directed toward bacteria property vagina Inflammation, trichomonal vaginitis, beads vaginitis, senile vahinitis, viral vaginitis, radioactivity vaginitis and aerobic bacteria property are cloudy Various types of colpitis such as road inflammation, therapeutic effect is obvious, short treating period and uneasy to recur.

Another object of the present invention is to provide a kind of preparation method of cypress Cape jasmine clearing damp spray, this preparation method can have Effect ground extracts the active ingredient of each medicinal material, plays that medicinal material is clearing heat and detoxicating, function of tonifying spleen and stopping diarrhea, and the spray being prepared can Effectively directed toward bacteria property vaginitis, trichomonal vaginitis, beads vaginitis, senile vahinitis, viral vaginitis, radioactivity Various types of colpitis such as vaginitis and aerobic bacteria property vaginitis, therapeutic effect is obvious, short treating period and uneasy to recur.

The present invention is solved its technical problem and realized using following technical scheme.

The present invention proposes a kind of cypress Cape jasmine clearing damp spray, the raw material system that cypress Cape jasmine clearing damp spray passes through following parts by weight meter Into：

10~20 parts of golden cypress, 10~15 parts of the Radix Astragali, 10~15 parts of rheum officinale, 5~10 parts of cape jasmine, 10~15 parts Sculellaria barbata, 10~20 parts of oldenlandia diffusa, 10~15 parts of honeysuckle, 10~20 parts of glutinous rehmannia, 10~15 parts of cordate houttuynia, 10~15 parts of oriental wormwood, 5~10 parts of small radix bupleuri, 1~5 part of Radix Isatidis, 5~10 parts of Asian puccoon, 1~5 part of scorpio, 5~ 10 parts of the capsule of weeping forsythia, 1~7 part of the stem pith of the rice-paper plant, 5~8 parts of the fruit of summer cypress, 5~10 parts of talcum, 10~15 parts of the wind-weed and 5~10 The radix glycyrrhizae of part.

As preferable scheme, cypress Cape jasmine clearing damp spray be made up of the raw material of following parts by weight meter 17 parts golden cypress, 13 parts of the Radix Astragali, 12 parts of rheum officinale, 10 parts of cape jasmine, 13 parts of Sculellaria barbata, 17 parts of oldenlandia diffusa, 13 parts of honeysuckle, 17 parts of glutinous rehmannia, 13 parts of cordate houttuynia, 13 parts of oriental wormwood, 6.7 parts of small radix bupleuri, 3.3 parts of Radix Isatidis, 6.7 parts of Asian puccoon, 3.3 parts of scorpio, 10 parts of the capsule of weeping forsythia, 5 parts of the stem pith of the rice-paper plant, 6.7 parts of the fruit of summer cypress, 10 parts of talcum, 13 parts of the wind-weed and 6.7 parts Radix glycyrrhizae.

It is further preferred that cypress Cape jasmine clearing damp spray also includes the essence that parts by weight are 0.1~0.3 part, essence is selected from Flavoring rose essence, cream jasmin france, Chinese cassia tree essence, red tangerine essence, Yilan essence, sandalwood fragrance and one kind in Salvia japonica essence or It is a variety of.

The present invention proposes a kind of preparation method of cypress Cape jasmine clearing damp spray, and it includes：By the first component temperature be 50~ Cut into slices under conditions of 65 DEG C to 1~2mm；

1~1.5h of ultramicro grinding is carried out under conditions of being 68~70 DEG C in temperature by the second component；

0.5~0.7h of ultramicro grinding is carried out under conditions of being 60~65 DEG C in temperature by third component；

The first component, the second component and third component after progress ultramicro grinding is mixed at a temperature of 60~62 DEG C Uniformly, the first mixture is formed；

By temperature of 500~700mL that the first mixture and volume fraction are 40~50% ethanol solution at 60~65 DEG C Degree is lower to be mixed, and is carried out first time 1.5~3h of ultrasonic extraction after 10~14h of immersion and obtained the second mixture；

Second mixture is filtrated to get the first filtrate and the first filter residue at a temperature of 1~4 DEG C；

By temperature of 1000~1400mL that the first filter residue and volume fraction are 40~50% ethanol solution at 60~65 DEG C Second of 0.5~2h of ultrasonic extraction is carried out after the lower mixing of degree, and is filtrated to get the second filtrate and the second filter residue；

By the first filtrate and the second filtrate 1~4 DEG C temperature mixing and be filtrated to get the 3rd filtrate；

Wherein, it is 10~20 parts of glutinous rehmannia that the first component, which includes parts by weight, the second component include parts by weight be 10~ 20 parts of golden cypress, 10~15 parts of the Radix Astragali, 10~15 parts of rheum officinale, 10~15 parts of Sculellaria barbata, 10~20 parts of oldenlandia Grass, 10~15 parts of the wind-weed, 10~15 parts of cordate houttuynia, 10~15 parts of oriental wormwood and 10~15 parts of honeysuckle, the 3rd group Divide the cape jasmine, 5~10 parts of small radix bupleuri, 1~5 part of Radix Isatidis, 5~10 parts of Asian puccoon, 1 for including that parts by weight are 5~10 parts ~5 parts of scorpio, 5~10 parts of the capsule of weeping forsythia, 1~7 part of the stem pith of the rice-paper plant, 5~8 parts of the fruit of summer cypress, 5~10 parts of talcum and 5~10 The radix glycyrrhizae of part.

The beneficial effect of the cypress Cape jasmine clearing damp spray of the embodiment of the present invention and preparation method thereof is：

The cypress Cape jasmine clearing damp spray of offer mainly include by golden cypress, radix scutellariae, rheum officinale, cape jasmine, Sculellaria barbata, oldenlandia diffusa, Honeysuckle, glutinous rehmannia, cordate houttuynia, oriental wormwood, radix bupleuri, Radix Isatidis, Asian puccoon (root), scorpio, the capsule of weeping forsythia, the stem pith of the rice-paper plant, the fruit of summer cypress, talcum, the wind-weed, The Ten Herbs material of radix glycyrrhizae two is prepared.By the rational proportion of this few taste medicine, this spray can not only be effectively for mould The vaginitis symptom of bacterium property vaginitis and trichomonas vaginitis, can also effectively directed toward bacteria property vaginitis, trichomonal vaginitis, thought Pearl vaginitis, senile vahinitis, viral vaginitis, radioactivity vaginitis and aerobic bacteria property vaginitis etc. are various types of Colpitis.Also, its therapeutic effect is obvious, short treating period and uneasy to recur.

Cypress Cape jasmine clearing damp spray of offer and preparation method thereof passes through the improvement on original Process ba- sis so that each The drug effect of raw material is effectively played so that this spray can not only be effectively for colpomycosis and trichomonas the moon The scorching vaginitis symptom in road, can also effectively directed toward bacteria property vaginitis, trichomonal vaginitis, beads vaginitis, senile vagina Inflammation, viral vaginitis, radioactivity vaginitis and wait various types of colpitis.Also, its therapeutic effect is obvious, the course for the treatment of It is short and uneasy to recur.

Embodiment

, below will be in the embodiment of the present invention to make the purpose, technical scheme and advantage of the embodiment of the present invention clearer Technical scheme be clearly and completely described.Unreceipted actual conditions person, builds according to normal condition or manufacturer in embodiment The condition of view is carried out.Agents useful for same or the unreceipted production firm person of instrument, it is the conventional production that can be obtained by commercially available purchase Product.

Cypress Cape jasmine clearing damp spray of the embodiment of the present invention and preparation method thereof is specifically described below.

A kind of cypress Cape jasmine clearing damp spray, cypress Cape jasmine clearing damp spray are made up of the raw material of following parts by weight meter：

Wherein, golden cypress bitter, it is cold in nature.It is clearing heat and detoxicating, purging intense heat eliminating dampness.Cure mainly acute bacillary dysentery, chordapsus, acute The inflammation such as icteric hepatitis, urinary system infection contamination.Burning hot wound, tympanitis, acute conjunctivitis etc. are controlled in external application.

Wherein, the Radix Astragali has an invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, the effect of expelling pus and promoting granulation.For treatment deficiency of vital energy weak, deficiency of food Loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, ulcer is difficult to burst, burst for a long time and does not holds back, blood deficiency chlorosis, Heat Diabetes.

Wherein, rheum officinale, nature and flavor：Hardship, tremble with fear, channel tropism：Stomach；Large intestine channel；Liver Channel；The spleen channel section category is categorized as polygonaceae, lets out clearly wet Heat, it can lead damp and hot from stool to go out.It is mainly used in jaundice, stranguria；Promoting blood circulation, for stagnant card of a variety of stasis of bloods etc.；Purging intense heat and detonicating, use In burning hot flourishing, hematemesis of the absurd row of urgent blood etc.；Heat and toxic materials clearing away, stagnated for Gastrointestinal excess heat, constipation, abdominal distension stomachache etc..

Wherein, the fruit of cape jasmine is traditional Chinese medicine, the l batches of medicine-food two-purpose resources that the category Ministry of Public Health promulgates, has protect liver, profit Courage, decompression, calmness, hemostasis, detumescence etc. act on.It is usually used in treating icteric hepatitis, bruise, hypertension, sugar in tcm clinical practice Urinate the diseases such as disease.The base of glycosides containing safran, can make weld.

Wherein, Sculellaria barbata sun plant all herbal medicine, there is the functions such as clearing heat and detoxicating, promoting blood circulation, swelling and pain relieving, anticancer. Cold in nature sour, herb is containing compositions such as multivitamin, trace element and amino acid.There is removing pattogenic heat from the blood and toxic material from the body, blood stasis removing analgesic, subside a swelling and clear The effect of hot dampness removing.

Wherein, oldenlandia diffusa patent medicine bitter, light, it is cold in nature.Primary efficacy is clearing heat and detoxicating, medicinal powder for relieving pain knot, promoting urination and removing dampness. Outstanding kind treatment all kinds inflammation.

Wherein, honeysuckle is described as clearing heat and detoxicating good medicine from ancient times.Its property sweet cold air fragrance, clear heat with drugs of sweet flavour and cold nature without injuring one's stomach, Fragrant reach thoroughly again can eliminating evil.Honeysuckle can dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile diseases, as body heat, dermexanthesis, Send out the diseases such as spot, heat toxin sore carbuncle, abscess of throat, equal significant effect.

Wherein, glutinous rehmannia has hypoglycemic, hemostasis, anti-inflammatory and other effects.

Wherein, cordate houttuynia acrid flavour, cold, return lung warp.Can it is clearing heat and detoxicating, detumescence treat sore, promoting urination and removing dampness, clearing away heat to cure dysentery, Stomach strengthening and digestion promoting, with control real heat, heat toxin, damp evil, disease heat be suffer from lung carbuncle, sore swollen toxin, hemorrhoidal hemorrhage, retention of heat in the spleen and stomach etc..It is modern Pharmacological evaluation shows that this product has the effect such as antibacterial, antiviral, raising immunity of organisms, diuresis.

Wherein, oriental wormwood has clearing heat and detoxicating, hypotensive, anti-inflammation, improves the effect such as immunologic function.

Wherein, small radix bupleuri harmonizing Sharyang, sharp liver and gall are dredged, in sensible table.For shaoyang disease, alternative fever and chill, fullness in chest and hypochondrium, write from memory Silent loss of appetite, vexation and vomiting, bitter taste in the mouth and dry throat are dizzy；Or abdominal pain, or hypochondriac pain, or yearningly, or cough, or profit, or throb with fear, or urine It is unfavorable, or waste heat is not understood after sweat, and disease is had a fever, married woman's typhoid fever invasion of blood chamber by heat.

Wherein, its is cold in nature for Radix Isatidis, and taste is first bitter after micro- sweet tea, has the effect of clearing heat and detoxicating, preventing cold, relieving sore-throat.It is main It is used to treat the diseases such as the dark reddish purple dark, scarlet fever of febrile virulent maculae, tongue.

Wherein, Asian puccoon major function cool blood, promoting blood circulation, promoting eruption of detoxifying.For blood-heat and toxin exuberance, atropurpureus macula, measles without adequate eruption, sore Ulcer, eczema, scald.Clearing heat and cooling blood, for measles, pyreticosis ecchymosis, eczema, hematuria, blood strangury, bloody flux, sore, erysipelas, burn Wound, constipation with heat retention.

Wherein, scorpio has relieving convulsion the effect of relieving dizziness, high fever, infantile convulsions, epilepsy, etc., removing obstruction in channels to relieve pain, and is usually used in treating trichomonas vaginitis disease.

Wherein, weeping forsythia concentrated decoction has antibacterial action in vitro, can suppress typhoid bacillus, paratyphosum Bacterium, Escherichia coli, Shigella dysenteriae, corynebacterium diphtheriae and comma bacillus, staphylococcus, streptococcus etc..

Wherein, the stem pith of the rice-paper plant is sweet；It is light；Cold nature, belong to heat clearing away and diuresis inducing medicine, clear snobbish water；Promoting lactation.The main puckery pain of stranguria；Urine It is unfavorable；Oedema；Jaundice；Damp-warm diseases；Scanty drak urine；Postpartum breast is few；Amenorrhea；Under band.For damp-warm syndrome urine, the puckery pain of gonorrhoea, oedema Oliguria, agalactia.

Wherein, the fruit of summer cypress is cold in nature, acrid flavour, hardship, cures mainly clearing heat and promoting diuresis, dispelling wind and arresting itching.For under difficulty and pain in micturition, pruritus vulvae band, Rubella, eczema, pruitus.

Wherein, talcum inducing diuresis for treating strangurtia, clearing away summerheat, clearing damp sore.For heat gonorrhea, urolithiasis, the puckery pain of urine heat, summer-heat and damp polydipsia, Damp and hot watery diarrhea；Control eczema, wet sore, prickly heat outside.The diseases such as puckery pain are dripped for difficult urination, leaching, the product such as plantain seed, akebi can be matched somebody with somebody；With In damp and hot caused watery diarrhea, Poria cocos, coix seed, plantain seed can be coordinated equally to use.Licorice, the fresh leaves of pulse plants can be coordinated hot summer weather illness Fragrant, fresh eupatorium is equally used；Control that damp-warm syndrome is uncomfortable in chest, scanty drak urine, the symphysis seed of jog's tears, the stem pith of the rice-paper plant can be matched somebody with somebody, the leaf of bamboo equally be used.

Wherein, the wind-weed is famous Chinese medicine, property bitter cold, there is nourishing Yin and falling fire, moisturize laxation, the effect of sharp stool and urine.Belong under heat-clearing Gunpowder, cure mainly:Warm heat disease, hyperpyrexia polydipsia, cough and asthma, cough caused by dryness, constipation, osteopyrexia and fever, restlessness of asrhenia type and insomnia, stranguria with turbid discharge of quenching one's thirst.

Wherein, radix glycyrrhizae gas is micro-, sweet and special.Major function is clearing heat and detoxicating, expelling phlegm and arresting coughing, gastral cavity abdomen etc..Happiness is dark moist, The low dry climate of the long temperature of sunshine.Radix glycyrrhizae with being grown in arid, semiarid desert steppe, desert edge and loess hill more Band.Root and root-like stock hyoscine.

As preferable scheme, cypress Cape jasmine clearing damp spray is mainly made up of the raw material of following parts by weight meter：7 parts of Huang Cypress, 13 parts of the Radix Astragali, 12 parts of rheum officinale, 10 parts of cape jasmine, 13 parts of Sculellaria barbata, 17 parts of oldenlandia diffusa, 13 parts of gold and silver Flower, 17 parts of glutinous rehmannia, 13 parts of cordate houttuynia, 13 parts of oriental wormwood, 6.7 parts of small radix bupleuri, 3.3 parts of Radix Isatidis, 6.7 parts of purple Grass, 3.3 parts scorpio, 10 parts of the capsule of weeping forsythia, 5 parts of the stem pith of the rice-paper plant, 6.7 parts of the fruit of summer cypress, 10 parts of talcum, 13 parts of the wind-weed and 6.7 parts of radix glycyrrhizae.Each composition using this obtained spray of proportioning can not only effectively for colpomycosis with it is trichomonas The vaginitis symptom of vaginitis, can also effectively directed toward bacteria property vaginitis, trichomonal vaginitis, beads vaginitis, senile the moon Various types of colpitis such as road inflammation, viral vaginitis, radioactivity vaginitis and aerobic bacteria property vaginitis.Also, its Therapeutic effect is obvious, short treating period and uneasy to recur.

It is further preferred that cypress Cape jasmine clearing damp spray also includes the essence that parts by weight are 0.1~0.3 part, essence can carry For enough fragrance to cover the taste of medicine in itself, user is more easily accepted by.Essence is selected from flavoring rose essence, cream jasmin france, meat One or more in osmanthus essence, red tangerine essence, Yilan essence, sandalwood fragrance and Salvia japonica essence.Flavoring rose essence is consoled And relexation.Cream jasmin france is consoled, analgesic activity.Chinese cassia tree essence can strengthening vital QI to eliminate pathogenic factors, anti-infective (anti-corrosive antibacterial).Red tangerine is fragrant Essence can inspire enthusiasm, and make us glad, additionally aid digestion.Yilan essence is adjustable and balance body function, console, it is tranquil and Relexation, anxiety can be eliminated, relieved pain, improvement sleep, treated hypertension, can also inspire enthusiasm, antidepression, recovers and enhancing is believed The heart.Sandalwood fragrance has relaxation, sedation, can antianxiety, depression and nervous, only have a headache.Salvia japonica essence can wind dispelling stop Bitterly, stomach invigorating, anti-inflammation, cardiac stimulant is anticonvulsion, stimulates the menstrual flow；Also breathing problem and rheumatalgia can be treated.Certainly, the present invention's In other embodiment, the species of essence can also be selected according to demand, and the present invention does not limit.

Embodiments of the invention additionally provide a kind of preparation method of cypress Cape jasmine clearing damp spray, including：

S1：Cut into slices under conditions of being 50~65 DEG C in temperature by the first component to 1~2mm.Carry out at this temperature Section can effectively ensure the humidity change of the first component, moisture during so as to ensure to be used as medicine, and then ensure first group The medicinal efficacy divided.Meanwhile by the first component slices to 1~2mm so that the drug effect of the first component is effectively played. Certainly, in other embodiments of the invention, the thickness of section is also finely adjusted within the specific limits, such as can be close 1mm is not limited either slightly larger than 2mm etc., the present invention.

S2：1~1.5h of ultramicro grinding is carried out under conditions of being 68~70 DEG C in temperature by the second component.It is same as above, Ultramicro grinding is carried out at this temperature can effectively place the drug powder after ultramicro grinding to be combined with the moisture in air, enter And the moisture of the second component can be ensured, drug effect is ensured with this.Certainly, the time of ultramicro grinding be can be according to demand It is adjusted, until meeting medication demand.Meanwhile sieved in the later stage in use, No. 1 can be used, weigh inventory.

S3：0.5~0.7h of ultramicro grinding is carried out under conditions of being 60~65 DEG C in temperature by third component.With phase above Together, the moisture knot in drug powder and air after ultramicro grinding can effectively place ultramicro grinding is carried out at this temperature Close, and then the moisture of the second component can be ensured, drug effect is ensured with this.Certainly, the time of ultramicro grinding be can root It is adjusted according to demand, until meeting medication demand.Meanwhile sieved in the later stage in use, No. 1 can be used, weigh and feed intake Amount.

It should be noted that the first component includes the glutinous rehmannia that parts by weight are 10~20 parts, the second component includes parts by weight Number is 10~20 parts of golden cypress, 10~15 parts of the Radix Astragali, 10~15 parts of rheum officinale, 10~15 parts of Sculellaria barbata, 10~20 parts Oldenlandia diffusa, 10~15 parts of the wind-weed, 10~15 parts of cordate houttuynia, 10~15 parts of oriental wormwood and 10~15 parts of gold and silver Flower, third component include parts by weight be 5~10 parts cape jasmine, 5~10 parts of small radix bupleuri, 1~5 part of Radix Isatidis, 5~10 parts Asian puccoon, 1~5 part of scorpio, 5~10 parts of the capsule of weeping forsythia, 1~7 part of the stem pith of the rice-paper plant, 5~8 parts of the fruit of summer cypress, 5~10 parts of talcum, And 5~10 parts of radix glycyrrhizae.It can be seen that from the classification of the second component and third component and the more raw material of dosage be divided into second Component, it is third component by the relatively large number of component of dosage.Second component is carried out under conditions of temperature is 68~70 DEG C 1~1.5h of ultramicro grinding.Third component is that 0.5~0.7h of ultramicro grinding is carried out under conditions of 60~65 DEG C.Can by contrast Know, the second amounts of components is more, and grinding time length, temperature is high, can fully crush each raw material by such design, protect simultaneously Change of moisture content of each raw material when crushing is demonstrate,proved, so that last mixed first component, the second component and the 3rd Component can play the drug effect of maximum.

As preferable scheme, the first component cut into slices and the second component and third component carry out ultramicro grinding it It is preceding also to include the first component, the second component and third component are chosen, cleaned and dried successively；

Wherein, selection is picked by taste, and removing is gone mouldy, damaged by worms, impurity, silt particle and non-medicinal effects, cleaning are by medicinal material It is seated in wash pond, water cleans in an opposite direction, must not soak, and the temperature dried is 55~65 DEG C, is dried to medicinal material moisture and is not higher than 13%.

As preferable scheme, first time ultrasonic extraction with include during second of ultrasonic extraction with 2000~ 2500r/min rotating speed is stirred, and the frequency of stirring is 10~15min/ times.Appropriate stirring can improve extraction into Effect so that the medical value of individual raw material performs to maximum.Certainly, in other embodiments of the invention, the rotating speed of stirring with And frequency can be selected according to demand, the present invention does not limit.

S4：By the first component, the second component and the third component after progress ultramicro grinding at a temperature of 60~62 DEG C It is well mixed, form the first mixture.Mixing can reduce the change of moisture at this temperature, ensure the drug effect of each raw material.

As preferable scheme, in addition to S5：Carry out operation of clearing out a gathering place.After pre-treatment and pulverizing process terminate, by operator Member is cleared out a gathering place by the SOP that clears out a gathering place, and all clear fills in record of clearing out a gathering place, and after QA passed examinations, provides the quality certification of clearing out a gathering place.

S6：By 500~700mL that the first mixture and volume fraction are 40~50% ethanol solution at 60~65 DEG C At a temperature of mix, and soak 10~14h after carry out first time 1.5~3h of ultrasonic extraction obtain the second mixture.Certainly, in this hair In bright other embodiment, the time of immersion is also not limited to 10~14h, can be floated around, and the present invention does not limit. Soaked using the ethanol of this concentration in 60~65 DEG C of temperature, sufficiently guarantee can be provided for the extraction of medicine, and then ensure Drug effect.

S7：Second mixture is filtrated to get the first filtrate and the first filter residue at a temperature of 1~4 DEG C.Need what is illustrated It is that the second mixture is to filter at low temperature, the precipitable material hair of most of low temperature during filter at low temperature in the second mixture Raw precipitation, admittedly the active ingredient for the first filtrate being filtrated to get is improved, reduces being mixed into for impurity, avoids influence Drug effect.

S8：By 1000~1400mL that the first filter residue and volume fraction are 40~50% ethanol solution at 60~65 DEG C At a temperature of mix after carry out second of 0.5~2h of ultrasonic extraction, and be filtrated to get the second filtrate and the second filter residue.

S9：By the first filtrate and the second filtrate 1~4 DEG C temperature mixing and be filtrated to get the 3rd filtrate.With above-mentioned original Manage it is identical, at low temperature filtering cause impurity fully precipitate, the filtrate being filtrated to get is purer, and drug effect is more preferable.

As preferable scheme, embodiments of the invention also include：

S10：3rd filtrate is mixed to 1000mL at room temperature with the ethanol solution that volume fraction is 40~50% and obtained 3rd mixture.Clearing damp spray can be made by being mixed with ethanol solution.

S11：3rd mixture and parts by weight are mixed to get the 4th mixture, essence choosing for 0.1~0.3 part of essence One kind from flavoring rose essence, cream jasmin france, Chinese cassia tree essence, red tangerine essence, Yilan essence, sandalwood fragrance and Salvia japonica essence It is or a variety of.

S12：The preparation method of cypress Cape jasmine clearing damp spray also includes successively being sterilized the 4th mixture, examined for the first time Look into, be canned, outer packing, second checking and finished product storage, with outer packing temperature being 18~26 DEG C wherein canned, humidity It is 45%~65%.

The feature and performance of the present invention are described in further detail with reference to embodiments.

Embodiment 1

A kind of cypress Cape jasmine clearing damp spray is present embodiments provided, it is prepared by the following method to obtain：

S1：First component, the second component and third component are chosen, cleaned and dried successively.

Wherein, the first component includes the glutinous rehmannia that parts by weight are 10 parts, and the second component includes the Huang that parts by weight are 10 parts Cypress, 10 parts of the Radix Astragali, 10 parts of rheum officinale, 5 parts of cape jasmine, 10 parts of Sculellaria barbata, 10 parts of oldenlandia diffusa, 10 parts of the wind-weed, 10 parts of cordate houttuynia, 10 parts of oriental wormwood and 10 parts of honeysuckle, third component include parts by weight be 5 parts small radix bupleuri, 1 part Radix Isatidis, 5 parts of Asian puccoon, 1 part of scorpio, 5 parts of the capsule of weeping forsythia, 1 part of the stem pith of the rice-paper plant, 5 parts of the fruit of summer cypress, 5 parts of talcum and 5 parts Radix glycyrrhizae.

Wherein, selection is picked by taste, and removing is gone mouldy, damaged by worms, impurity, silt particle and non-medicinal effects, cleaning are by medicinal material It is seated in wash pond, water cleans in an opposite direction, must not soak, and the temperature dried is 55 DEG C, is dried to medicinal material moisture not higher than 13%.

S2：Cut into slices under conditions of being 50 DEG C in temperature by the first component to 1mm；

S3：Ultramicro grinding 1h is carried out under conditions of being 68 DEG C in temperature by the second component；

S4：Ultramicro grinding 0.5h is carried out under conditions of being 60 DEG C in temperature by third component；

S5：Carry out operation of clearing out a gathering place；

S6：By the first component, the second component and the third component after progress ultramicro grinding at a temperature of 60~62 DEG C It is well mixed, form the first mixture；

S7：First mixture is mixed with the ethanol solution for the 500mL that volume fraction is 40% at a temperature of 60 DEG C, and First time ultrasonic extraction 1.5h, which is carried out, after immersion 10h obtains the second mixture, while with the frequency of 10min/ times, with 2000r/ Min rotating speed is stirred；

S8：Second mixture is filtrated to get the first filtrate and the first filter residue at a temperature of 1 DEG C；

S9：First filter residue is mixed with the ethanol solution for the 1000mL that volume fraction is 40% at a temperature of 60~65 DEG C After carry out second of ultrasonic extraction 0.5h, and be filtrated to get the second filtrate and the second filter residue, while with the frequency of 10min/ times, with 2000r/min rotating speed is stirred；

S10：By the first filtrate and the second filtrate 1 DEG C temperature mixing and be filtrated to get the 3rd filtrate；

S11：3rd filtrate is mixed to 1000mL at room temperature with the ethanol solution that volume fraction is 40% and obtains the 3rd Mixture.

S12：3rd mixture and parts by weight are mixed to get the 4th mixture for 0.1 part of essence, essence is selected from rose Rare essence, cream jasmin france, Chinese cassia tree essence, red tangerine essence, Yilan essence, sandalwood fragrance and one kind or more in Salvia japonica essence Kind.

S13：4th mixture is sterilized successively, inspections for the first time, canned, outer packing, second inspection and into Product are put in storage, wherein canned and outer packing temperature is 18 DEG C, humidity is 45%.

Embodiment 2

Wherein, the first component includes the glutinous rehmannia that parts by weight are 10~20 parts, and it is 17 parts that the second component, which includes parts by weight, Golden cypress, 13 parts of the Radix Astragali, 12 parts of rheum officinale, 10 parts of cape jasmine, 13 parts of Sculellaria barbata, 17 parts of oldenlandia diffusa, 13 parts Cordate houttuynia, 13 parts of oriental wormwood, 13 parts of the wind-weed and 13 parts of honeysuckle, it is 6.7 parts small that third component, which includes parts by weight, Radix bupleuri, 3.3 parts of Radix Isatidis, 6.7 parts of Asian puccoon, 3.3 parts of scorpio, 10 parts of the capsule of weeping forsythia, 5 parts of the stem pith of the rice-paper plant, 6.7 parts of summer cypress Son, 10 parts of talcum and 6.7 parts of radix glycyrrhizae.

Wherein, selection is picked by taste, and removing is gone mouldy, damaged by worms, impurity, silt particle and non-medicinal effects, cleaning are by medicinal material It is seated in wash pond, water cleans in an opposite direction, must not soak, and the temperature dried is 60 DEG C, is dried to medicinal material moisture not higher than 13%.

S2：Cut into slices under conditions of being 55 DEG C in temperature by the first component to 1.5mm；

S3：Ultramicro grinding 1.3h is carried out under conditions of being 69 DEG C in temperature by the second component；

S4：Ultramicro grinding 0.6h is carried out under conditions of being 62 DEG C in temperature by third component；

S5：Carry out operation of clearing out a gathering place；

S6：The first component, the second component and third component after progress ultramicro grinding is mixed at a temperature of 61 DEG C Uniformly, the first mixture is formed；

S7：First mixture and volume fraction are mixed for 45% 600mL ethanol solution at a temperature of 60~65 DEG C Close, and soak and first time ultrasonic extraction 2h is carried out after 12h obtain the second mixture, while with the frequency of 12min/ times, with 2200r/min rotating speed is stirred；

S8：Second mixture is filtrated to get the first filtrate and the first filter residue at a temperature of 2 DEG C；

S9：The ethanol solution for the 1200mL that first filter residue and volume fraction are 45% is mixed at a temperature of 62 DEG C laggard Second of ultrasonic extraction 1h of row, and the second filtrate and the second filter residue are filtrated to get, while with the frequency of 12min/ times, with 2200r/ Min rotating speed is stirred；

S10：By the first filtrate and the second filtrate 2 DEG C temperature mixing and be filtrated to get the 3rd filtrate；

S11：3rd filtrate is mixed to 1000mL at room temperature with the ethanol solution that volume fraction is 45% and obtains the 3rd Mixture.

S12：3rd mixture and parts by weight are mixed to get the 4th mixture for 0.2 part of essence, essence is selected from rose Rare essence, cream jasmin france, Chinese cassia tree essence, red tangerine essence, Yilan essence, sandalwood fragrance and one kind or more in Salvia japonica essence Kind.

S13：4th mixture is sterilized successively, inspections for the first time, canned, outer packing, second inspection and into Product are put in storage, wherein canned and outer packing temperature is 20 DEG C, humidity is 50%.

Embodiment 3

Wherein, the first component includes the glutinous rehmannia that parts by weight are 20 parts, and the second component includes the Huang that parts by weight are 20 parts Cypress, 15 parts of the Radix Astragali, 15 parts of rheum officinale, 10 parts of cape jasmine, 15 parts of Sculellaria barbata, 20 parts of oldenlandia diffusa, 10~15 parts The wind-weed, 15 parts of cordate houttuynia, 15 parts of oriental wormwood and 15 parts of honeysuckle, third component include the small bavin that parts by weight are 10 parts Recklessly, 5 parts of Radix Isatidis, 10 parts of Asian puccoon, 5 parts of scorpio, 10 parts of the capsule of weeping forsythia, 7 parts of the stem pith of the rice-paper plant, 8 parts of the fruit of summer cypress, 10 parts of cunning Stone and 10 parts of radix glycyrrhizae.

Wherein, selection is picked by taste, and removing is gone mouldy, damaged by worms, impurity, silt particle and non-medicinal effects, cleaning are by medicinal material It is seated in wash pond, water cleans in an opposite direction, must not soak, and the temperature dried is 65 DEG C, is dried to medicinal material moisture not higher than 13%.

S2：Cut into slices under conditions of being 65 DEG C in temperature by the first component to 2mm；

S3：Ultramicro grinding 1.5h is carried out under conditions of being 70 DEG C in temperature by the second component；

S4：Ultramicro grinding 0.7h is carried out under conditions of being 65 DEG C in temperature by third component；

S5：Carry out operation of clearing out a gathering place；

S7：First mixture and volume fraction are mixed for 50% 500~700mL ethanol solution at a temperature of 65 DEG C Close, and soak and first time ultrasonic extraction 3h is carried out after 14h obtain the second mixture, while with the frequency of 15min/ times, with 2500r/min rotating speed is stirred；

S8：Second mixture is filtrated to get the first filtrate and the first filter residue at a temperature of 4 DEG C；

S9：After being mixed at a temperature of 60~65 DEG C of the ethanol solution for the 1400mL that the first filter residue and volume fraction are 50% Second of ultrasonic extraction 2h is carried out, and is filtrated to get the second filtrate and the second filter residue, while with the frequency of 15min/ times, with 2500r/min rotating speed is stirred；

S10：By the first filtrate and the second filtrate 4 DEG C temperature mixing and be filtrated to get the 3rd filtrate；

S11：3rd filtrate is mixed to 1000mL at room temperature with the ethanol solution that volume fraction is 50% and obtains the 3rd Mixture.

S12：3rd mixture and parts by weight are mixed to get the 4th mixture for 0.3 part of essence, essence is selected from rose Rare essence, cream jasmin france, Chinese cassia tree essence, red tangerine essence, Yilan essence, sandalwood fragrance and one kind or more in Salvia japonica essence Kind.

S13：4th mixture is sterilized successively, inspections for the first time, canned, outer packing, second inspection and into Product are put in storage, wherein canned and outer packing temperature is 26 DEG C, humidity is 65%.

Comparative example 1

Commercially available treatment vaginitis medicine.

Experimental example 1

40 ages close same type of trichomonas vaginitis patient is chosen, is divided into four groups, and respectively by the present invention The quality vaginitis medicine that is provided with comparative example 1 of the cypress Cape jasmine clearing damp spray that provides of embodiment 1 to embodiment 3 be respectively acting on this 4 groups of trichomonas vaginitis patient.Meanwhile each embodiment uses external application with comparative example, appropriate sprinkling and private parts, one day 1 ~2 times, ten days are a course for the treatment of, observe and record the recovery from illness situation of patient after a course for the treatment of, as a result as shown in table 1.

The trichomonas vaginitis patient of table 1. recovery from illness situation

Numbering	3 (my god)	5 (my god)	7 (my god)	10 (my god)
					Embodiment 1	1	3	6	0
Embodiment 2	0	2	7	1
					Embodiment 3	1	2	5	2
Comparative example 1	0	0	0	0

It can be seen from the data that table 1 is shown, cypress Cape jasmine clearing damp spray of the invention can cure trichomonas in a course for the treatment of Vaginitis patient, and the mass effect of commercially available medicine is relatively poor, has no recovery from illness patient.

Experimental example 2

20 ages close bacterial vaginitis, trichomonal vaginitis, beads vaginitis, senile vagina are chosen respectively Inflammation, viral vaginitis, radioactivity vaginitis and aerobic bacteria property vaginitis patient, are equally divided into 2 groups, and respectively by the present invention The quality vaginitis medicine that provides of embodiment 2 the cypress Cape jasmine clearing damp spray and the comparative example 1 that provide be respectively acting on this 2 groups of difference The vaginitis patient of type.Meanwhile each embodiment uses external application with comparative example, appropriate sprinkling and private parts, 1~2 time on the one, Ten days are a course for the treatment of, observe and record the recovery from illness situation of different type patient after a course for the treatment of, as a result as shown in table 2.

The different type patient of table 2. recovery from illness situation

Numbering	Experimental example 2	Comparative example 1
			Bacterial vaginitis	10	2
Trichomonal vaginitis	10	3
			Beads vaginitis	10	1
Senile vahinitis	10	5
			Viral vaginitis	10	2
Radioactivity vaginitis	10	3
			Aerobic bacteria property vaginitis	10	5

It can be seen from the data that table 2 is shown, cypress Cape jasmine clearing damp spray of the invention can cure various types of in a course for the treatment of The vaginitis patient of type, and the mass effect of commercially available medicine is relatively poor, recovery from illness patient is relatively fewer.

In summary, cypress Cape jasmine clearing damp spray that embodiments of the invention provide and preparation method thereof is by original work Improvement on skill basis so that the drug effect of each raw material is effectively played so that this spray can not only effectively pin , can also effectively directed toward bacteria property vaginitis, trichomonad vagina to colpomycosis and the vaginitis symptom of trichomonas vaginitis Inflammation, beads vaginitis, senile vahinitis, viral vaginitis, radioactivity vaginitis and wait various types of colpitis. Also, its therapeutic effect is obvious, short treating period and uneasy to recur.

Embodiments described above is part of the embodiment of the present invention, rather than whole embodiments.The reality of the present invention The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of the selected implementation of the present invention Example.Based on the embodiment in the present invention, what those of ordinary skill in the art were obtained under the premise of creative work is not made Every other embodiment, belongs to the scope of protection of the invention.

Claims

A kind of 1. cypress Cape jasmine clearing damp spray, it is characterised in that the original that the cypress Cape jasmine clearing damp spray passes through following parts by weight meter Material is made：

10~20 parts of golden cypress, 10~15 parts of the Radix Astragali, 10~15 parts of rheum officinale, 5~10 parts of cape jasmine, the half of 10~15 parts Lotus, 10~20 parts of oldenlandia diffusa, 10~15 parts of honeysuckle, 10~20 parts of glutinous rehmannia, 10~15 parts of cordate houttuynia, 10~ 15 parts of oriental wormwood, 5~10 parts of small radix bupleuri, 1~5 part of Radix Isatidis, 5~10 parts of Asian puccoon, 1~5 part of scorpio, 5~10 parts The capsule of weeping forsythia, 1~7 part of the stem pith of the rice-paper plant, 5~8 parts of the fruit of summer cypress, 5~10 parts of talcum, 10~15 parts of the wind-weed and 5~10 parts Radix glycyrrhizae.
2. cypress Cape jasmine clearing damp spray according to claim 1, it is characterised in that the cypress Cape jasmine clearing damp spray mainly by with The raw material of lower parts by weight meter is made：

17 parts of the golden cypress, 13 parts of the Radix Astragali, 12 parts of the rheum officinale, 10 parts of the cape jasmine, described the half of 13 parts Branch lotus, 17 parts of the oldenlandia diffusa, 13 parts of the honeysuckle, 17 parts of the glutinous rehmannia, 13 parts of the cordate houttuynia, 13 Part the oriental wormwood, 6.7 parts of the small radix bupleuri, 3.3 parts of the Radix Isatidis, 6.7 parts of the Asian puccoon, 3.3 parts described Scorpio, 10 parts of the capsule of weeping forsythia, 5 parts of the stem pith of the rice-paper plant, 6.7 parts of the fruit of summer cypress, 10 parts of the talcum, 13 parts described The wind-weed and 6.7 parts of the radix glycyrrhizae.
3. cypress Cape jasmine clearing damp spray according to claim 1 or 2, it is characterised in that the cypress Cape jasmine clearing damp spray is also wrapped It is 0.1~0.3 part of essence to include parts by weight, the essence be selected from flavoring rose essence, cream jasmin france, Chinese cassia tree essence, red tangerine essence, One or more in Yilan essence, sandalwood fragrance and Salvia japonica essence.
A kind of 4. preparation method of cypress Cape jasmine clearing damp spray, it is characterised in that including：

Cut into slices under conditions of being 50~65 DEG C in temperature by the first component to 1~2mm；

1~1.5h of ultramicro grinding is carried out under conditions of being 68~70 DEG C in temperature by the second component；

0.5~0.7h of ultramicro grinding is carried out under conditions of being 60~65 DEG C in temperature by third component；

First component, the second component and third component after progress ultramicro grinding is mixed at a temperature of 60~62 DEG C Uniformly, the first mixture is formed；

By temperature of 500~700mL that first mixture and volume fraction are 40~50% ethanol solution at 60~65 DEG C Degree is lower to be mixed, and is carried out first time 1.5~3h of ultrasonic extraction after 10~14h of immersion and obtained the second mixture；

Second mixture is filtrated to get the first filtrate and the first filter residue at a temperature of 1~4 DEG C；

By temperature of 1000~1400mL that first filter residue and volume fraction are 40~50% ethanol solution at 60~65 DEG C Second of 0.5~2h of ultrasonic extraction is carried out after the lower mixing of degree, and is filtrated to get the second filtrate and the second filter residue；

By first filtrate and second filtrate 1~4 DEG C temperature mixing and be filtrated to get the 3rd filtrate；

Wherein, first component includes the glutinous rehmannia that parts by weight are 10~20 parts, and second component is including parts by weight 10~20 parts of golden cypress, 10~15 parts of the Radix Astragali, 10~15 parts of rheum officinale, 10~15 parts of Sculellaria barbata, 10~20 parts of white flower HERBA HEDYOTIS DIFFUSAE, 10~15 parts of the wind-weed, 10~15 parts of cordate houttuynia, 10~15 parts of oriental wormwood and 10~15 parts of honeysuckle, institute Stating third component includes the cape jasmine, 5~10 parts of small radix bupleuri, 1~5 part of Radix Isatidis, 5~10 parts that parts by weight are 5~10 parts Asian puccoon, 1~5 part of scorpio, 5~10 parts of the capsule of weeping forsythia, 1~7 part of the stem pith of the rice-paper plant, 5~8 parts of the fruit of summer cypress, 5~10 parts of talcum, And 5~10 parts of radix glycyrrhizae.
5. the preparation method of cypress Cape jasmine clearing damp spray according to claim 4, it is characterised in that the first time ultrasound carries Take with including being stirred with 2000~2500r/min rotating speed during second of ultrasonic extraction, the frequency of stirring For 10~15min/ times.
6. the preparation method of cypress Cape jasmine clearing damp spray according to claim 4, it is characterised in that the cypress Cape jasmine clearing damp spraying The preparation method of agent also include by the 3rd filtrate and volume fraction for 40~50% ethanol solution mix at room temperature to 1000mL obtains the 3rd mixture.
7. the preparation method of cypress Cape jasmine clearing damp spray according to claim 6, it is characterised in that the cypress Cape jasmine clearing damp spraying The preparation method of agent, which also includes the 3rd mixture and parts by weight being mixed to get the 4th for 0.1~0.3 part of essence, mixes Compound, the essence are selected from flavoring rose essence, cream jasmin france, Chinese cassia tree essence, red tangerine essence, Yilan essence, sandalwood fragrance and mouse One or more in tail hay-scented essence.
8. the preparation method of cypress Cape jasmine clearing damp spray according to claim 7, the preparation side of the cypress Cape jasmine clearing damp spray Method also includes successively being sterilized the 4th mixture, inspections for the first time, canned, outer packing, second inspection and into Product are put in storage, wherein canned and outer packing temperature is 18~26 DEG C, humidity is 45%~65%.
9. the preparation method of cypress Cape jasmine clearing damp spray according to claim 4, it is characterised in that enter in first component Row section and second component and the third component carry out ultramicro grinding before also including by first component, described Second component and the third component are chosen, cleaned and dried successively；

Wherein, selection is picked by taste, and removing is gone mouldy, damaged by worms, impurity, silt particle and non-medicinal effects, cleaning are to put medicinal material In wash pond, water cleans in an opposite direction, must not soak, and the temperature dried is 55~65 DEG C, is dried to the medicinal material moisture and is not higher than 13%.
10. the preparation method of the cypress Cape jasmine clearing damp spray according to any one of claim 4 to 9, it is characterised in that by institute The ethanol solution for 500~700mL that the first mixture and volume fraction are 40~50% is stated at a temperature of 60~65 DEG C Also include carrying out operation of clearing out a gathering place before mixing.