CN106266239A - Improve compositions of memory and its preparation method and application - Google Patents
Improve compositions of memory and its preparation method and application Download PDFInfo
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- CN106266239A CN106266239A CN201610820506.6A CN201610820506A CN106266239A CN 106266239 A CN106266239 A CN 106266239A CN 201610820506 A CN201610820506 A CN 201610820506A CN 106266239 A CN106266239 A CN 106266239A
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- schisandrae chinensis
- fructus
- radix notoginseng
- fructus lycii
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/50—Methods involving additional extraction steps
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
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- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
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- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of compositions improving memory and its preparation method and application, belong to pharmaceutical technology field.The effective ingredient of said composition is prepared from by the medical material of following weight portion: Fructus Schisandrae Chinensis 26 parts, Radix Ginseng 39 parts, Radix Notoginseng 13 parts, Fructus Lycii 6 12 parts.Fang Zhong, for this etiology and pathogenesis of senile dementia, selecting Zishen fill fine, QI invigorating dissipating blood stasis is method for the treatment of, with Fructus Schisandrae Chinensis QI invigorating yin fluid astringing, replenishing kidney-essence as monarch drug, with Radix Ginseng and Radix Notoginseng QI invigorating Fructus Alpiniae Oxyphyllae, promoting blood circulation to remove blood stasis altogether as ministerial drug, with Fructus Lycii the kidney invigorating and essence nourishing, foster healthy energy as adjuvant drug, in order to promote the recovery of memory of elderly person and cognitive disorder, improve the Chinese medicine of memory effect for exploitation and health food provides foundation.
Description
Technical field
The present invention relates to medicine and food technology field, particularly relate to a kind of compositions improving memory and preparation side thereof
Method and application.
Background technology
Hypomnesis, the traditional Chinese medical science claims forgetful, forgetful, forgetfulness.Primary disease is clinical common with old people, therefore it is silly to be frequently referred to old age
Slow-witted.China's traditional medicine is thought, senile dementia belongs to the category of the traditional Chinese medical science " dementia ", and " Plain Questions five is hidden and generated a piece " has cloud: " all
Marrow person, comes under brain ", " Ling Shu Miraculous Pivot or Divine Axis sea opinion " is said: " the brain being the reservoir of the marrow, is that it covers on it is defeated, under at windy mansion ", " Elementary Medicine "
Cloud: " all marrows come under brain for brain person, the sea of marrow, therefore up to brain, down to tail sacrum, all road of marrow lifting also ", discussed above all
Illustrate that brain is that marrow collects part.Being used it follows that brains fill the whether prosperous cerebral swelling that can directly affect, the main memory of human brain is also
Must must nourish with brains as material base with source place, only brain abundance, brain, the normal learning and memory of competence exertion
The functions such as thinking.Filling of brains is prosperous, and it has relation with the vital organs of the human body, but especially with kidney for wanting.The kidney being the origin of congenital constitution, envelope Tibetan
This, the raw marrow of store essential substances and on lead in brain, as " Ling Shu Miraculous Pivot or Divine Axis passages through which vital energy circulates " cloud: " people is begun raw, first becomes essence, and essence becomes and brains are raw ", Tang of the Qing Dynasty
Rong Chuan also says that in its " ancient Chinese medical classics essential ideas " " things is not forgotten, and relies this memory, remembers wherein, then in kidney essense.Kidney-tonifying and sperm-producing,
Turn to marrow, and hide in brain ", it is seen that kidney essense is the main matter source of replenishing the brain and spinal cord, and it is full that essence fills then marrow, and damage of essence then marrow is empty.
Therefore clinically should be with kidney tonifying, essence replenishing as basic therapy, old people has the disease of qi and blood stagnation more due to Qi deficiency physique simultaneously, resistance
Hinder kidney essense that brain is taken a tonic or nourishing food to build up one's health.
Summary of the invention
Based on this, it is an object of the invention to provide a kind of compositions improving memory, said composition is for old people's
Feature, has the effect preferably improving memory.
A kind of compositions improving memory, the effective ingredient of described compositions is prepared from by the medical material of following weight portion:
Fructus Schisandrae Chinensis 2-6 part, Radix Ginseng 3-9 part, Radix Notoginseng 1-3 part, Fructus Lycii 6-12 part.
The present invention is according to traditional Chinese medicine theory, and combines modern medicine, has selected Fructus Schisandrae Chinensis, Radix Ginseng, Radix Notoginseng and Fructus Lycii
Carry out compatibility, Fang Zhong:
Fructus Schisandrae Chinensis, sour in the mouth, sweet, warm in nature, return lung, the heart, kidney channel.There is convergence astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, effect of kidney calming.With
In chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, deficient pulse of losing heart, and interior-heat is quenched one's thirst, the heart
Throb with fear insomnia etc..Fructus Schisandrae Chinensis main component is lignanoid and polysaccharide, and modern pharmacology research shows, Fructus Schisandrae Chinensis has obvious blood fat reducing
Protect the liver, tranquillizing and allaying excitement and antioxidative effect.Reusing Fructus Schisandrae Chinensis in we is monarch drug, it is intended to play its QI invigorating yin fluid astringing, nourishing kidney
Effect of essence.
Radix Ginseng, sweet in the mouth, micro-hardship, property is flat, tepor, returns spleen, lung, heart channel.Effect is strongly invigorating primordial QI, and invigorating the spleen to benefit the lung only promotes the production of body fluid
Yearningly, Fructus Alpiniae Oxyphyllae of calming the nerves, mend all empty.The main component of Radix Ginseng is ginsenoside, polysaccharide and volatile oil.Radix Notoginseng, sweet in the mouth, micro-hardship, property
Temperature, returns liver, stomach warp.There is dissipating blood stasis hemostasis, effect of subduing swelling and relieving pain, be mainly used in treating epistaxis, have blood in stool, metrorrhagia, spit blood, tell
The diseases such as blood, traumatic hemorrhage, chest and abdomen twinge.Modern pharmacy research confirms, Radix Notoginseng mainly includes saponin, flavone compound, it is possible to
Improving blood supply of cardiac muscle and coronary artery dilating, in Radix Notoginseng, sitosterol and daucosterol also have the effect of blood fat reducing in addition.With Radix Ginseng in side
It is ministerial drug altogether with Radix Notoginseng, while auxiliary monarch drug Fructus Schisandrae Chinensis performance QI invigorating consolidates effect, plays Fructus Alpiniae Oxyphyllae of calming the nerves, fill up brain sky
Empty effect.
Fructus Lycii, sweet in the mouth, property are flat；Return liver, kidney, lung meridian.There is the effects such as the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, the lung moistening and production of body fluid promoting.With
In asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat quenches one's thirst, and blood deficiency and yellow complexion, blurred vision is failed to understand.The main component of Fructus Lycii is Chinese holly
Qi polysaccharide, glycine betaine, carotenoid and carotenoids ester and multivitamin and aminoacid, lot of documents reports, Fructus Lycii has
It is improved immunity, nervous system regulation function, protects the liver, lowering blood pressure and blood fat, blood sugar lowering and the effect of slow down aging.We
With Fructus Lycii as adjuvant drug, in order to the kidney invigorating and essence nourishing, foster healthy energy, play slow down aging, enhancing by improving body immunity
The effect of memory ability.
Accordingly, the present invention reuses Fructus Schisandrae Chinensis is monarch drug, it is intended to play its QI invigorating yin fluid astringing, effect of replenishing kidney-essence；With Radix Ginseng
It is ministerial drug altogether with Radix Notoginseng, while auxiliary monarch drug Fructus Schisandrae Chinensis performance QI invigorating consolidates effect, plays Fructus Alpiniae Oxyphyllae of calming the nerves, fill up brain sky
Empty effect；And with Fructus Lycii as adjuvant drug, in order to the kidney invigorating and essence nourishing, foster healthy energy, play prolong by improving body immunity
Slow old and feeble, the effect of hypermnesis ability.
Described in an embodiment, the effective ingredient of compositions is prepared from by the medical material of following weight portion wherein:
Fructus Schisandrae Chinensis 6 parts, Radix Ginseng 9 parts, Radix Notoginseng 1 part, Fructus Lycii 6 parts.
The bright preparation method also disclosing the above-mentioned compositions improving memory of this law, comprises the following steps:
Fructus Schisandrae Chinensis extracts: weigh Fructus Schisandrae Chinensis by weight, and adding volumn concentration is the ethanol water of 60%-90%, 50-80
DEG C extract, filter, filtrate concentrate, obtain Fructus Schisandrae Chinensis fluid extract；
Radix Ginseng extracts: weigh Radix Ginseng by weight, and adding volumn concentration is the ethanol water of 60%-100%, 70-100 DEG C
Extracting, filter, filtrate concentrates, and obtains ginseng liquid extract；
Radix Notoginseng is extracted: weigh Radix Notoginseng by weight, and adding volumn concentration is the ethanol water of 30%-70%, and 50-90 DEG C carries
Taking, filter, filtrate concentrates, and obtains Radix Notoginseng fluid extract；
Fructus Lycii is extracted: weigh Fructus Lycii by weight, and adding volumn concentration is the ethanol water of 0%-30%, and 80-100 DEG C carries
Taking, filter, filtrate concentrates, and obtains Fructus Lycii fluid extract；
Mixing: take above-mentioned Fructus Schisandrae Chinensis fluid extract, ginseng liquid extract, Radix Notoginseng fluid extract and Fructus Lycii fluid extract, mix homogeneously, to obtain final product.
Above-mentioned preparation method, extracts the effective ingredient in medical material, improves the convenience that patient takes, and should
Preparation method is simple for process, it is easy to carry out commercial production.
Wherein in an embodiment, during described Fructus Schisandrae Chinensis extracts, weigh Fructus Schisandrae Chinensis by weight, add by every gram of Fructus Schisandrae Chinensis
Entering the ethanol water that 10-18ml volumn concentration is 70%-80%, 60-70 DEG C is extracted 1-3hr, filters, and filtrate concentrates,
Fructus Schisandrae Chinensis fluid extract.
Wherein in an embodiment, during described Radix Ginseng extracts, weigh Radix Ginseng by weight, add 7-by every gram of Radix Ginseng
13ml volumn concentration is the ethanol water of 75%-85%, and 80-90 DEG C is extracted 1-3 time, and each 1-3hr filters, and merges filter
Concentrate after liquid, obtain ginseng liquid extract.
During Radix Notoginseng described in an embodiment is extracted wherein, weigh Radix Notoginseng by weight, add 6-by every gram of Radix Notoginseng
10ml volumn concentration is the ethanol water of 45%-55%, and 65-75 DEG C is extracted 1-3 time, and each 1-3hr filters, and merges filter
Concentrate after liquid, obtain Radix Notoginseng fluid extract.
During Fructus Lycii described in an embodiment is extracted wherein, weigh Fructus Lycii by weight, add 7-by every gram of Fructus Lycii
13ml water, 90-100 DEG C is extracted 1-3 time, and each 1-3hr filters, and concentrates, obtain Fructus Lycii fluid extract after merging filtrate.
The invention also discloses combinations of the above thing and there is in preparation pharmaceutical preparation or the health product system improving memory effect
Application in agent.
Wherein in an embodiment, described pharmaceutical preparation is oral liquid, hard capsule, soft capsule, tablet, pill, drop pill
Agent, granule, powder, honey ointment agent or distillate medicinal water.
Wherein in an embodiment, described health-care preparation is teabag or medicated wine.
Compared with prior art, the method have the advantages that
The compositions improving memory of the present invention, for this etiology and pathogenesis of senile dementia, selects Zishen fill fine, QI invigorating dissipating blood stasis
For method for the treatment of, with Fructus Schisandrae Chinensis QI invigorating yin fluid astringing, replenishing kidney-essence as monarch drug, with Radix Ginseng and Radix Notoginseng QI invigorating Fructus Alpiniae Oxyphyllae, promoting blood circulation to remove blood stasis altogether as ministerial drug,
With Fructus Lycii the kidney invigorating and essence nourishing, foster healthy energy as adjuvant drug, in order to promote the recovery of memory of elderly person and cognitive disorder.
This anti-Fatigue Composition is in Chinese medicine theoretical basis, then is carried out by mice step-through test and water maze laboratory
Functional component screening and formula design, the most just obtain have the Chinese medicine formula clearly improving memory, improves for exploitation
The Chinese medicine of memory and health food provide foundation.
Further, after each raw material is coordinated with specific ratio, there is extraordinary effect, be orally administered to said composition 30 days
After, carrying out water maze laboratory, mice finds the time of platform compared with model group, has significant difference.
Detailed description of the invention
Explain in detail the explanation present invention below in conjunction with specific embodiment, but the present invention is not caused any restriction.
Crude drug and adjuvant employed in following example are the most commercially available.
Embodiment 1
A kind of compositions improving memory, is prepared from by following medical material:
Fructus Schisandrae Chinensis 6g, Radix Ginseng 9 g, Radix Notoginseng 1 g, Fructus Lycii 6 g.
Follow these steps to above-mentioned raw materials prepare:
Fructus Schisandrae Chinensis extracts: weigh Fructus Schisandrae Chinensis by weight, and adding 14ml volumn concentration by every gram of Fructus Schisandrae Chinensis is the ethanol of 75%
Aqueous solution, 65 DEG C of water-baths are extracted 2hr, filtration, filtrate concentration, are obtained Fructus Schisandrae Chinensis fluid extract.
Radix Ginseng extracts: weigh Radix Ginseng by weight, adds, by every gram of Radix Ginseng, the ethanol water that 10ml volumn concentration is 80%
Solution, 85 DEG C of water-baths extract 2 times, each 1hr, filter, concentrate, obtain ginseng liquid extract after merging filtrate.
Radix Notoginseng is extracted: weigh Radix Notoginseng by weight, adds, by every gram of Radix Notoginseng, the ethanol water that 8ml volumn concentration is 50%
Solution, 70 DEG C of water-baths extract 2 times, each 2hr, filter, concentrate, obtain Radix Notoginseng fluid extract after merging filtrate.
Fructus Lycii is extracted: weigh Fructus Lycii by weight, adds 10ml water by every gram of Fructus Lycii, and 100 DEG C are extracted 3 times, each 3hr,
Filter, concentrate after merging filtrate, obtain Fructus Lycii fluid extract.
Mixing: take above-mentioned Fructus Schisandrae Chinensis fluid extract, ginseng liquid extract, Radix Notoginseng fluid extract and Fructus Lycii fluid extract, mix homogeneously, do
Dry, compositions A of memory must be improved.
Embodiment 2
A kind of compositions improving memory, is prepared from by following medical material:
Fructus Schisandrae Chinensis 2g, Radix Ginseng 9 g, Radix Notoginseng 3g, Fructus Lycii 12 g.
Prepare according to the method for embodiment 1, obtain improving compositions B of memory.
Comparative example 1
A kind of compositions of this comparative example preparation, essentially identical with the compositions improving memory of embodiment 1, difference is,
The compositions of this comparative example is prepared from by following medical material:
Fructus Schisandrae Chinensis 6g, Radix Ginseng 9 g, Radix Notoginseng 1 g.
Method with reference to embodiment 1 prepares compositions C.
Comparative example 2
A kind of compositions of this comparative example preparation, essentially identical with the compositions improving memory of embodiment 1, difference is,
The compositions of this comparative example is prepared from by following medical material:
Fructus Schisandrae Chinensis 6g, Radix Notoginseng 1 g, Fructus Lycii 6 g.
Method with reference to embodiment 1 prepares compositions D.
Comparative example 3
A kind of compositions of this comparative example preparation, essentially identical with the compositions improving memory of embodiment 1, difference is,
The compositions of this comparative example is prepared from by following medical material:
Radix Ginseng 9 g, Radix Notoginseng 1 g, Fructus Lycii 6 g.
Method with reference to embodiment 1 prepares compositions E.
Comparative example 4
A kind of compositions of this comparative example preparation, essentially identical with the compositions improving memory of embodiment 1, difference is,
The compositions of this comparative example is prepared from by following medical material:
Fructus Schisandrae Chinensis 6g, Radix Ginseng 9 g, Fructus Lycii 6 g.
Method with reference to embodiment 1 prepares compositions F.
Comparative example 5
A kind of compositions of this comparative example preparation, essentially identical with the compositions improving memory of embodiment 1, difference is,
The compositions of this comparative example is prepared from by following medical material:
Fructus Schisandrae Chinensis 6g, Radix Ginseng 9 g, Radix Notoginseng 1 g, Fructus Lycii 6 g, Fructus Alpiniae Oxyphyllae 6g.
Method with reference to embodiment 1 prepares compositions G.
Experimental example 1
Taking above-described embodiment and compositions that comparative example prepares, carry out mice step-through test, method is as follows:
1, laboratory animal.
Healthy ICR male mice, body weight 20 ± 2g, Jilin University's Animal Experimental Study center provide, credit number is
SCXK-(is lucky) 2015-0005, it is put in peace and quiet, humiture environment suitable, draughty after point cage, freely drinks water, rationally take the photograph
Food, adapts to local environment and starts experiment after 7 days.
2, experimental technique.
ICR mice is randomly divided into blank group (gavage gives distilled water), compositions A group, compositions B group, combination
Thing C group, compositions D group, compositions E group, compositions F group, compositions G group, the continuous gavage that mice carries out 30 days by a definite date is given
Medicine, dosage be 0.1ml/10g(compositions compound concentration be 0.366g/ml).
After 29th day gavage 30 min, carry out step-through test.Will put into and keep away dark instrument septum reset hole dorsad and put into by mice
Bright room, starts timer simultaneously.When being subject to wrong with mice entrance arrival darkroom, hole, the time of timer record is and hides
Phase.Mice is trained 5 min by this experiment, and records the errors number of mice in 5 min.Carry out after being administered 30 minutes next day
Second time test.The incubation period recording every Mus and the errors number occurred in 5min.
3, experimental result.
Experimental result is as shown in the table.
Table 1. respectively organize mice keep away dark result of the test (, n=15)
Note: compare with normal group, * P < 0.05.
The above results shows, through the continuous gastric infusion mice of 30 days, compares with the mice of blank, and mice keeps away dark examination
Test middle errors number to significantly reduce.
Further, in the compositions of the present invention, the disappearance of medical material the most simply, all the improvement memory effect to this product produce certain
Impact, therefore four taste Chinese crude drugs are indispensable, and increase medical material simply, and its effect is also not as the compatibility of this four tastes Chinese crude drug.
Compared with Example 2, use the optimum proportioning of embodiment 1, there is the improvement memory effect of optimum.
Experimental example 2
Taking compositions A that above-described embodiment 1 prepares, carry out mice and keep away dark test, method is as follows:
1, laboratory animal.
Healthy ICR male mice, body weight 20 ± 2g, Jilin University's Animal Experimental Study center provide, credit number is
SCXK-(is lucky) 2015-0005, it is put in peace and quiet, humiture environment suitable, draughty after point cage, freely drinks water, rationally take the photograph
Food, adapts to local environment and starts experiment after 7 days.
2, experimental technique.
ICR mice is randomly divided into blank group (gavage gives distilled water), (gavage gives distilled water, abdomen to model group
Chamber injection scopolamine 5mg/kg), compositions A low dose group, dosage group in compositions A, compositions A high dose group, by each group
Mice presses the continuous gastric infusion of 0.1ml/10g capacity 30 days, once a day.(compositions A basic, normal, high dosage formulation concentration is respectively
For 0.183g/ml, 0.366 g/ml, 0.732g/ml).
Within 29th day and the 30th day, proceed by gavage and keep away dark test.Within 29th day, starting training, before training, 30 min enter
Row gastric infusion, after gastric infusion 20min, blank group mouse peritoneal injecting normal saline, model group and other each group are little
Mus lumbar injection 5mg/kg scopolamine hydrobromide.After lumbar injection 10min, mice is put into and keeps away dark instrument septum reset hole dorsad
Put into bright room, start timer simultaneously.Enter arrival darkroom, hole with mice to be by the time of timer record during mistake
Incubation period.Mice is trained 5 min by this experiment, and records the errors number of mice in 5 min.Within 30th day, enter in gastric infusion
Row second time test, medication was with the 29th day.The incubation period recording every Mus and the errors number occurred in 5min.
3, experimental result.
Experimental result is as shown in the table.
Table 2. respectively organize mice keep away dark result of the test (, n=15)
Note: compare with blank group, * * P < 0.01；Compare with model group, #P < 0.05, ##P < 0.01；Compare with middle dosage group, ▲ P
< 0.05, ▲ ▲ P < 0.01.
The above results shows, compares with blank group, and model group mice substantially shortens (P < 0.01) incubation period, and errors number is bright
Aobvious increase (P < 0.01), shows modeling success；Compare with model group, middle and high dosage group mice be obviously prolonged incubation period (P <
0.05, P < 0.01), errors number significantly reduces (P < 0.05, P < 0.01)；And along with the increase of dosage, incubation period is gradually
Extending (low dose group and high dose group compare with middle dosage group respectively, P < 0.05, P < 0.01), errors number gradually decreases (low
Dosage group and high dose group compare with middle dosage group respectively, P < 0.05).Test result indicate that, above-mentioned composition has improvement note
Recall effect, and this effect exists dose dependent.
Experimental example 3
Taking above-described embodiment and compositions that comparative example prepares, carry out mice Morris water maze laboratory, method is as follows:
1, laboratory animal.
Healthy ICR male mice, body weight 20 ± 2g, Jilin University's Animal Experimental Study center provide, credit number is
SCXK-(is lucky) 2015-0005, it is put in peace and quiet, humiture environment suitable, draughty after point cage, freely drinks water, rationally take the photograph
Food, adapts to local environment and starts experiment after 7 days.
2, experimental technique.
ICR mice is randomly divided into blank group (gavage gives distilled water), (gavage gives distilled water, abdomen to model group
Chamber injection scopolamine 5mg/kg), compositions A group, compositions B group, compositions C group, compositions D group, compositions E group, combination
Thing F group, compositions G group, press the continuous gastric infusion of 0.1ml/10g capacity 30 days by each group of mice, once a day.Dosage is
0.1ml/10g(compositions compound concentration is 0.366g/ml).
Within 25th day, carrying out water maze test in gastric infusion, before training, 30 min carry out gastric infusion, gastric infusion
After 20min, blank group mouse peritoneal injecting normal saline, to model group, compositions A group, compositions B group, compositions C
Group, compositions D group, compositions E group, compositions F group, compositions G group carry out lumbar injection scopolamine 5mg/kg.Lumbar injection
After 10min, being placed on by mice in Morris water maze video tracking test system WMT-100, the training time arranging mice sets
Being set to 120s, the mice being not up to terminal in 120s presses 120s record.Before experiment, mice is placed near platform for the first time,
It is made automatically to climb up 3 times.Before training, mice is placed near platform so that it is independently climb up platform once the most every time.Every
24 h train 1 time, continue to be administered during training, and medication was with the 25th day.Gather the experimental data being administered the 29th day.It is administered the
Platform being removed statistics mice spatial search capability in 30 days, medication was with the 25th day.And record the number of mice spanning platform time
Experimental result.
2, experimental result.
Experimental result is as shown in the table.
Table 3 respectively organize Mice water maze orientation navigation and explore result (, n=15)
Note: compare with blank group, * * P < 0.01；Compare with model group, #P < 0.05, ##P < 0.01.
The above results shows, compared with model group, compositions A and the B group of embodiment 1 and 2 preparation find plateau time bright
Aobvious shortening；Further, through platform number of times showed increased.
Further, in the compositions of the present invention, the disappearance of medical material the most simply, all the improvement memory effect to this product produce certain
Impact, therefore four taste Chinese crude drugs are indispensable, and increase medical material simply, and its effect is also not as the compatibility of this four tastes Chinese crude drug.
Compared with Example 2, use the optimum proportioning of embodiment 1, there is the improvement memory effect of optimum.
Each technical characteristic of embodiment described above can combine arbitrarily, for making description succinct, not to above-described embodiment
In all possible combination of each technical characteristic be all described, but, as long as there is not lance in the combination of these technical characteristics
Shield, is all considered to be the scope that this specification is recorded.
Embodiment described above only have expressed the several embodiments of the present invention, and it describes more concrete and detailed, but also
Can not therefore be construed as limiting the scope of the patent.It should be pointed out that, come for those of ordinary skill in the art
Saying, without departing from the inventive concept of the premise, it is also possible to make some deformation and improvement, these broadly fall into the protection of the present invention
Scope.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (10)
1. the compositions improving memory, it is characterised in that the effective ingredient of described compositions is by the medical material of following weight portion
It is prepared from:
Fructus Schisandrae Chinensis 2-6 part, Radix Ginseng 3-9 part, Radix Notoginseng 1-3 part, Fructus Lycii 6-12 part.
The most according to claim 2 improve memory compositions, it is characterised in that the effective ingredient of described compositions by with
The medical material of lower weight portion is prepared from:
Fructus Schisandrae Chinensis 6 parts, Radix Ginseng 9 parts, Radix Notoginseng 1 part, Fructus Lycii 6 parts.
3. the preparation method of the compositions improving memory described in any one of claim 1-2, it is characterised in that include following step
Rapid:
Fructus Schisandrae Chinensis extracts: weigh Fructus Schisandrae Chinensis by weight, and adding volumn concentration is the ethanol water of 60%-90%, 50-80
DEG C extract, filter, filtrate concentrate, obtain Fructus Schisandrae Chinensis fluid extract；
Radix Ginseng extracts: weigh Radix Ginseng by weight, and adding volumn concentration is the ethanol water of 60%-100%, 70-100 DEG C
Extracting, filter, filtrate concentrates, and obtains ginseng liquid extract；
Radix Notoginseng is extracted: weigh Radix Notoginseng by weight, and adding volumn concentration is the ethanol water of 30%-70%, and 50-90 DEG C carries
Taking, filter, filtrate concentrates, and obtains Radix Notoginseng fluid extract；
Fructus Lycii is extracted: weigh Fructus Lycii by weight, and adding volumn concentration is the ethanol water of 0%-30%, and 80-100 DEG C carries
Taking, filter, filtrate concentrates, and obtains Fructus Lycii fluid extract；
Mixing: take above-mentioned Fructus Schisandrae Chinensis fluid extract, ginseng liquid extract, Radix Notoginseng fluid extract and Fructus Lycii fluid extract, mix homogeneously, to obtain final product.
4. the preparation method of the compositions improving memory described in claim 3, it is characterised in that during described Fructus Schisandrae Chinensis extracts,
Weighing Fructus Schisandrae Chinensis by weight, adding 10-18ml volumn concentration by every gram of Fructus Schisandrae Chinensis is the ethanol water of 70%-80%,
60-70 DEG C is extracted 1-3hr, filters, and filtrate concentrates, and obtains Fructus Schisandrae Chinensis fluid extract.
5. the preparation method of the compositions improving memory described in claim 3, it is characterised in that during described Radix Ginseng extracts, press
Weight portion weighs Radix Ginseng, and adding 7-13ml volumn concentration by every gram of Radix Ginseng is the ethanol water of 75%-85%, 80-90 DEG C
Extract 1-3 time, each 1-3hr, filter, concentrate after merging filtrate, obtain ginseng liquid extract.
6. the preparation method of the compositions improving memory described in claim 3, it is characterised in that during described Radix Notoginseng is extracted, press
Weight portion weighs Radix Notoginseng, adds, by every gram of Radix Notoginseng, the ethanol water that 6-10ml volumn concentration is 45%-55%, 65-75 DEG C
Extract 1-3 time, each 1-3hr, filter, concentrate after merging filtrate, obtain Radix Notoginseng fluid extract.
7. the preparation method of the compositions improving memory described in claim 3, it is characterised in that during described Fructus Lycii is extracted, press
Weight portion weighs Fructus Lycii, adds 7-13ml water by every gram of Fructus Lycii, and 90-100 DEG C is extracted 1-3 time, and each 1-3hr filters, and merges filter
Concentrate after liquid, obtain Fructus Lycii fluid extract.
8. the compositions described in any one of claim 1-2 has pharmaceutical preparation or the health product system improving memory effect in preparation
Application in agent.
Application the most according to claim 8, described pharmaceutical preparation is oral liquid, hard capsule, soft capsule, tablet, pill, drips
Pill, granule, powder, honey ointment agent or distillate medicinal water.
Application the most according to claim 8, described health-care preparation is teabag or medicated wine.
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| CN110522820A (en) * | 2018-05-23 | 2019-12-03 | 山东省农业可持续发展研究所 | A kind of slow health care product and preparation method thereof invigorated that declines of the strong kidney of person in middle and old age |
| CN109793834A (en) * | 2019-03-30 | 2019-05-24 | 漯河医学高等专科学校 | A kind of Chinese medicine preparation improving immunity |
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