CN107582899B - Mongolian medicine for clearing heat and stopping bleeding and its preparing process - Google Patents
Mongolian medicine for clearing heat and stopping bleeding and its preparing process Download PDFInfo
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Abstract
The invention relates to a medicine and a manufacturing process thereof, in particular to a Mongolian medicine for clearing heat and stopping bleeding and a manufacturing process thereof, which are characterized in that: the Mongolian medicine comprises the following raw material medicines in parts by weight: 1-2 parts of geniposide, 1-2 parts of rutin, 1-2 parts of carthamin, 1-2 parts of beta-sitosterol, 1-2 parts of emodin, 1-2 parts of glycyrrhizic acid, 1-2 parts of kutkin, 1-2 parts of alizarin, 1-2 parts of alkannin, 1-2 parts of shellac resin, 3-5 parts of calcium carbonate, 3-5 parts of calcium phosphate, 3-5 parts of amino acid, 2-3 parts of cholic acid and 2-3 parts of bezoar. The beneficial effects are that: has the functions of clearing heat, cooling blood and stopping bleeding, has obvious curative effect on hematemesis, hematochezia, menorrhagia, traumatic hemorrhage, liver cirrhosis and other hemorrhagic diseases, has low toxic and side effects, wide applicable crowd range, convenient taking, convenient digestion and absorption and quick response, and is expected to become a typical medicine for treating the lung diseases.
Description
Technical Field
The invention relates to a medicine and a preparation method thereof, in particular to a Mongolian medicine for clearing heat and stopping bleeding and a preparation process thereof.
Background
Mongolian medicine has unique treatment methods for hematemesis, hematochezia, menorrhagia, traumatic hemorrhage, liver cirrhosis and other hemorrhagic diseases, and Mongolian medicines mainly used for clearing liver heat and clearing blood heat and used for astringing pus blood and stopping vomiting are used as adjuvant medicines to form various formulas. Although the Mongolian medicine has good treatment effect, due to the lack of modern technical means, the action mechanism of the medicine is fuzzy, the effective components are more uncertain, and the medicine is prepared by adopting the ancient method, the effective components and the ineffective components are mixed together, the dosage is large, the effect is slow, the toxic and side effects are strong, the medicine is inconvenient to take, the storage and the transportation are inconvenient, and the development and the utilization of the Mongolian medicine are limited.
Disclosure of Invention
The invention aims to provide a heat-clearing and bleeding-stopping Mongolian medicine which has obvious curative effects on hematemesis, hematochezia, excessive menstrual blood, traumatic hemorrhage, liver diseases and the like, has definite action mechanism, greatly reduced ineffective components, small dosage, quick effect, low toxic and side effects, is convenient to take and store and transport, and a preparation process of the medicine.
The above purpose is realized by the following technical scheme: a Mongolian medicine for clearing heat and stopping bleeding is characterized in that: the Mongolian medicine comprises the following raw material medicines in parts by weight: 1-2 parts of geniposide, 1-2 parts of rutin, 1-2 parts of carthamin, 1-2 parts of beta-sitosterol, 1-2 parts of emodin, 1-2 parts of glycyrrhizic acid, 1-2 parts of kutkin, 1-2 parts of alizarin, 1-2 parts of alkannin, 1-2 parts of shellac resin, 3-5 parts of calcium carbonate, 3-5 parts of calcium phosphate, 3-5 parts of amino acid, 2-3 parts of cholic acid and 2-3 parts of bezoar.
3-5 parts of calcium carbonate, 3-5 parts of calcium phosphate and 3-5 parts of amino acid are replaced by 20-40 parts of animal cutin.
The animal cutin 20-80 parts comprises buffalo horn concentrated powder 20 parts or antler 30 parts or ox horn 40 parts or crinis Carbonisatus 25-30 parts.
One or more of the geniposide, rutin, carthamin beta-sitosterol, emodin, glycyrrhizic acid, picrorhizin, alizarin, alkannin and cholic acid is/are respectively replaced by one or more of the following raw material medicines: 1-2 parts of geniposide and 1-2 parts of rutin are replaced by 25-30 parts of gardenia or 25-30 parts of ruta; 1-2 parts of carthamin are replaced by 25-30 parts of safflower; 1-2 parts of beta-sitosterol are replaced by 25-30 parts of adenophora stricta or 25-30 parts of pseudo-ginseng; 1-2 parts of emodin are replaced by 25-30 parts of dianthus superbus or 25-30 parts of rheum officinale; 1-2 parts of glycyrrhizic acid are replaced by 25-30 parts of liquorice; 1-2 parts of picrorhiza rhizome are replaced by 25-30 parts of picrorhiza rhizome; 1-2 parts of alizarin are replaced by 25-30 parts of madder; 1-2 parts of alkannin are replaced by 25-30 parts of lithospermum; 1-2 parts of lac resin are replaced by 25-30 parts of lacca; 1-2 parts of cholic acid is replaced by 25-30 parts of one or more of ox gall, sheep gall and pig gall or by 25-30 parts of arisaema cum bile.
One or more of 25-30 parts of trogopterus dung, 25-30 parts of palm ash and 25-30 parts of agrimony are added into the raw material medicines.
The Mongolian medicine comprises the following raw material medicines in parts by weight: 25-30 parts of ruta graveolens, 25-30 parts of safflower, 25-30 parts of pseudo-ginseng, 25-30 parts of rheum officinale, 25-30 parts of liquorice, 25-30 parts of rhizoma picrorhizae, 25-30 parts of madder, 25-30 parts of lithospermum, 25-30 parts of lacca, 25-30 parts of sheep gall and pig gall with equal amount, 25-30 parts of crinis carbonisatus, 25-30 parts of artificial bezoar, 25-30 parts of trogopterus dung, 25-30 parts of palm ash and 25-30 parts of agrimony.
The processing method of the ox horn and the antler comprises the steps of soaking the ox horn and the antler in 75% ethanol or sterilizing the ox horn and the antler by steam, and crushing the ox horn and the antler into fine powder; adding 10 times of water by weight, decocting for two times, each time for 7-10 hours, and supplementing the distilled water at any time in the decocting process; mixing decoctions, filtering, concentrating the filtrate to 1-5% of the original weight, drying at 80 deg.C below, pulverizing into fine powder, and sieving; mixing with other raw materials, and making into pill, powder, unguent or capsule.
Pulverizing fructus Gardeniae, Carthami flos, Notoginseng radix or radix Adenophorae, herba Dianthi or radix et rhizoma Rhei, Glycyrrhrizae radix, rhizoma picrorhizae, radix Rubiae, radix Arnebiae, and Lacca, sieving with 80 mesh sieve, mixing, extracting with 70% ethanol for 30-60 min, and recovering ethanol under reduced pressure; extracting with ethyl acetate for 30-60 min, recovering solvent, concentrating, pulverizing, sieving with 60 mesh sieve, mixing with other raw materials, and making into pill, powder, ointment or capsule.
The invention has the beneficial effects that: has the functions of clearing heat, cooling blood and stopping bleeding, has obvious curative effect on hematemesis, hematochezia, menorrhagia, traumatic hemorrhage, liver cirrhosis and other hemorrhagic diseases, has low toxic and side effects, wide applicable crowd range, convenient taking, convenient digestion and absorption and quick response, and is expected to become a typical medicine for treating the lung diseases.
Detailed Description
The first embodiment:
the Mongolian medicine for clearing heat and stopping bleeding is developed and comprises the following raw material medicines in parts by weight: 1-2 parts of geniposide, 1-2 parts of rutin, 1-2 parts of carthamin, 1-2 parts of beta-sitosterol, 1-2 parts of emodin, 1-2 parts of glycyrrhizic acid, 1-2 parts of kutkin, 1-2 parts of alizarin, 1-2 parts of alkannin, 1-2 parts of shellac resin, 3-5 parts of calcium carbonate, 3-5 parts of calcium phosphate, 3-5 parts of amino acid, 2-3 parts of cholic acid and 2-3 parts of bezoar.
Mixing the above materials, and making into pill, powder, unguent or capsule.
The taking method comprises the following steps: the medicine is taken 1-2 g/time for adult and 2-3 times daily.
Brief introduction of raw material medicine:
geniposide, english name: gardenoside, alias: the hydroxy-isogeniposide, geniposide and isogeniposide have a molecular formula of C17H24O11, belong to sugar and glycoside, and have the effects of relieving diarrhea, relieving pain, promoting bile flow, resisting inflammation, treating soft tissue injury, inhibiting gastric secretion and reducing amylopsin.
Rutin, also known as: rutin Rutin, vitamin P, purple quercitrin, Rutoside, Violaquercitrin, molecular formula C27H30O 16.3H 2O1, has the functions of anti-inflammation, antivirus, maintaining blood vessel resistance, reducing permeability, reducing fragility and the like, is mainly used for treating burn, arthritis, capillary hemorrhage with increased fragility and various vascular diseases clinically, and is used for adjuvant therapy of hypertension to prevent cerebral hemorrhage; can also be used for preventing and treating vascular purpura, acute hemorrhagic nephritis, diabetic retinal hemorrhage, recurrent epistaxis, traumatic pulmonary hemorrhage, and puerperal hemorrhage.
Carthamin, a Chinese medicine II and a freeze-dried preparation, is a water-soluble flavonoid compound extracted from safflower, and pharmacodynamic literature data report that the carthamin has the effects of reducing coronary resistance, increasing coronary flow and increasing myocardial nutrition. Carthamin can reduce range and degree of experimental myocardial infarction of rabbit, and improve injury and necrotic electrocardiogram change. Pharmacodynamic studies show that carthamin 7-28mg/kg can remarkably inhibit the ST segment increase of an epicardium electrogram caused by left coronary artery ligation of dogs, reduce the release of serum acid kinase and reduce the myocardial infarction area. Carthamin has obvious effects on experimental thrombosis and platelet aggregation of rats.
Emodin, alternative name: cinnabar lotus leaf extract A, English name: emodin, chemical name: 1', 3', 8-trihydroxy-6-methylanthraquinone, molecular formula: C15H10O5, emodin can be used as cathartic, and combined with sugar to form glycosides, and has better purgative effect. It also has antibacterial, antitussive, antitumor, and blood pressure lowering effects. Emodin has antitumor, antibacterial, immunity enhancing, heart tonifying, blood pressure lowering, antitussive, diuretic, purgative, gallbladder promoting, spasmolytic, and immunity enhancing effects.
Beta-sitosterol, in English, sitosterol, also known as beta-sitosterol, phytosterol, (3 beta) -stigmast-5-en-3-ol, sitosterol. Molecular formula C29H 50O. Sterols are physiologically active substances, and can be used in medicine for promoting wound healing, promoting muscle proliferation, and enhancing capillary circulation. Sitosterol is nontoxic, has no irritation to skin, has remarkable anti-inflammatory effect, and can be used for treating skin cancer and skin ulcer, reducing cholesterol, relieving cough, eliminating phlegm, inhibiting tumor and repairing tissue. Can be used for treating hypercholesterolemia, atherosclerosis, chronic tracheitis, early stage cervical cancer, skin ulcer, etc.
Glycyrrhizic acid, Radix Glycyrrhizae, also known as glycyrrhizin, with the molecular formula of C42H62O16, is the most important active ingredient in licorice. The medicine is used for relieving cough, eliminating phlegm, gastric ulcer, acute and chronic gastritis, eczema, skin pruritus, hepatitis, hyperlipidemia, papilloma virus and conjunctivitis, and treating cancer and AIDS, has inhibiting effect on sarcoma and cancer cell growth, has high AIDS inhibiting rate up to 90%, and has strong effect of enhancing immunity.
Shikonin, english name shikonin, synonym shikonin, general name: 5, 8-dihydroxy-2- [ (1R) -1-hydroxy-4-methylpent-3-enyl ] naphthalene-1, 4-dione, molecular formula C16H16O5, is a crystalline powder, and is present in the root of Lithospermum erythrorhizon Sieb. et Zucc, Boraginaceae, Lithospermum erythrorhizon [ Arnebia euchroma (Royle) Johnst ], and other plants. Alkannin can also be produced by cell culture of Lithospermum erythrorhizon Sieb. et Zuce. Has anticancer, antiinflammatory, and antibacterial effects. It can be used for treating acute and chronic hepatitis, and liver cirrhosis (ascites). The family Dermatology is used for treating flat warts, psoriasis, for treating burns and for promoting wound healing by topical application. The eye drop can be used for treating herpes simplex keratitis, and has therapeutic effect on epithelial dendritic keratitis and superficial parenchymal layer dendritic keratitis. The oil can be used for treating infantile dermatitis, eczema, vaginitis, and cervicitis. The toothpaste containing the product can be used for preventing and treating dental caries and gingivitis.
Shellac resin, which is the main active ingredient of natural resin secreted from branches of laccaiceae insect Shellac (Lac), accounts for about 5-6% of natural resin, has a molecular weight of about 2194, and consists of four molecules of terpenic acid (i.e., three molecules of laccolic acid (jalaric acid) or epilaccolic acid (epilachialaric acid) and one molecule of laccolic acid (epilaccishanolic acid)) and four molecules of elaeostearic acid (aleuritic acid) per molecule. According to experiments, the shellac resin has the effects of clearing away heat and toxic materials, cooling blood and activating blood circulation, eliminating dampness and killing insects, cooling blood and detoxifying.
Picrorhizin is a stable mixed crystal of picrorhizin I (picroside I) and picroside (Kutkoside), and is mostly present in the rhizome of picrorhiza scrophulariiflora Pennell and picrorhiza kurroa Royle of Scrophulariaceae family. Experiments prove that the picrorhiza rhizome is the main effective component of the picrorhiza rhizome, has the effects of reducing deficiency heat, eliminating malnutritional fever, clearing heat, drying dampness, purging fire and detoxifying, and has good curative effects on yin deficiency, bone steaming, tidal fever, night sweat, infantile malnutrition, damp-heat diarrhea and dysentery, jaundice, hematemesis, epistaxis, conjunctival congestion, swelling and pain, carbuncle swelling, sore and ulcer, hemorrhoid pyogenic infections and the like.
Alizarin, the English name is Alizarin, the alias name is 1, 2-dihydroxy-9, 10-anthracenedione 1, 2-hydroxyanthraquinone Alizarin 1, 2-dihydroxy 1, 2-dihydroxyricin, the molecular formula is C14H8O4, the Alizarin has the effect of inhibiting the growth of staphylococcus aureus, can inhibit the permeability of connective tissues of rat skin, and has the anti-inflammatory effect similar to rutin.
Calcium carbonate, molecular formula: CaCO 3. The light calcium carbonate can be used as a leavening agent, a flour treating agent, an anticaking agent, an acidity regulator, a nutrition enhancer, a curing agent and the like. The said gum can be used for various foods and gum bases which need to be added with puffing agent according to GMP. Can also be used as flour improver, and the maximum usage amount is 0.03%; 7.5-18 g/kg of milk powder; 4-20 g/kg of soymilk powder and soybean powder; 0.4-3.4 g/kg of soft drink; 6-8 g/kg of lotus root starch; 2-7 g/kg of the instant breakfast cereal product. FDA (184.1192,2000) is not restricted, but is in GMP. When the product is used as a leavening agent, the product is often used together with other varieties, and the leavening agent obtained by compounding the product with sodium bicarbonate, alum and the like slowly releases carbon dioxide when heated, so that food can generate uniform and fine leavening bodies, and the quality of cakes, bread and biscuits can be improved. In addition, the calcium carbonate has the function of strengthening calcium, and the smaller the calcium carbonate particles, the easier the calcium carbonate particles are to absorb. In Japan, light calcium carbonate is used as a leavening agent, and is generally used in an amount of 1% in foods. It can also be used as feed nutrition enhancer. Calcium carbonate is the main component of the calcite of the mongolian medicine and has the effects of clearing away the heat of the body, stopping vomiting, stopping diarrhea, helping digestion, detoxifying, breaking the stuffiness, healing wound, setting bone and regulating vitality and the like.
Calcium phosphate, tribasic, formula (Ca3(PO4)2), is insoluble in ethanol and acetone, slightly soluble in water, and readily soluble in dilute hydrochloric and nitric acids. Can be used as anticaking agent, acidity regulator, nutritional supplement, flavoring agent, stabilizer, and water retention agent. Are used in the food industry as anticaking agents, acidity regulators, nutritional supplements, flavoring agents, stabilizers, moisture retention agents. The food additive use health standard (GB2760-2011) of China stipulates: the calcium phosphate can be used for wheat flour, and the maximum usage amount is 0.03 g/kg; 8.0g/kg of solid beverage; 2.0g/kg of fried potato chips. Can be used as moisture retention agent in flour. FAO/WHO regulations: can be used as anticaking agent for glucose powder and sucrose powder, with maximum dosage of 15g/kg (alone or in combination with other anticaking agent, without starch); milk powder, cream powder, 5g/kg (alone or in combination with other stabilizers, on an anhydrous basis); for vending machines, 10g/kg of milk powder, 1g/kg of cream powder (alone or in combination with other anti-caking agents), soup and soup, 15mg/kg (alone or in combination with stearates and silica, referred to as dehydrated product); cocoa powder and sugary cocoa powder, 10g/kg (alone or in combination with other anti-caking agents, sugary cocoa powder is used only in vending machines). The stabilizer can be used in light condensed milk, sweetened condensed milk and cream, and the dosage is 2g/kg (single use) and 3g/kg (combined with other stabilizer), all based on anhydrous substance. The amount used for processing the cheese was 9g/kg (total phosphate, in terms of phosphorus). The product can be used as calcium element enhancer for cookies and bread, etc., and has dosage of 3g/kg for cereal powder and 20g/kg for solid beverage, both in terms of calcium element. The calcium phosphate is the main component of animal bones of deer, cattle, sheep, pig and the like which are traditional Chinese medicines for Mongolian medicine, and has the effects of detoxifying, soothing the nerves, resisting convulsion, strengthening the body and the like.
The amino acid (amino acid) is a general name of a class of organic compounds containing amino groups and carboxyl groups, and the basic constituent unit of macromolecular protein is a basic substance of protein required by animal nutrition. The amino acids include various amino acids, such as lysine, alanine, arginine, aspartic acid, cystine, leucine, proline, tyrosine, histidine, and valine.
The name of cholic acid in English is 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid, the name of CAS is 81-25-4, the Chinese alternative names of 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid, cholic acid, cyclosporine, 3,17, 12-Trihydroxy-isovaleric acid, anhydrous cholic acid, 3,7, 12-Trihydroxy-cholanic acid, cholic acid, Trihydroxy-5 cholanic acid and the molecular formula is C24H40O 5. The product is present in bile of cattle, sheep, and pig. Cholic acid is synthesized by the liver, is excreted into the duodenum along with bile, and is one of the components of digestive juice, and can promote the digestion and absorption of lipid substances. Cholate is an emulsifier for fats and oils, and helps the hydrolysis and absorption of fats and oils in the intestine. Cholic acid also has spasmolytic, stomach invigorating, and blood cholesterol reducing effects.
Bezoar Bos taurus domesticus Gmelin, also called Xihuang, Rhinocerotis flava and Chongbao, is a gallstone of the liver of a bovine animal belonging to the class of mammalians of the phylum chordata. It contains cholic acid 5-11%, deoxycholic acid 2%, chenodeoxycholic acid 0.6-1.7% and its salts, bilirubin and its calcium salt, cholesterol, ergosterol, lecithin, fatty acid, vitamin D, water-soluble peptide SMC, and copper, iron, magnesium, zinc, etc. Australia produced bezoar contains a plurality of amino acids such as carotenoid, alanine, glycine, taurine (taurine), aspartic acid, arginine, leucine, methionine and the like. The traditional Chinese medicine considers that the bezoar gas is fragrant, slightly bitter and then sweet in taste and cool in nature. Can be used for clearing away heat and toxic materials and arresting convulsion. It is used orally for high fever, coma, mania, infantile convulsion, and externally for sore throat, aphtha, carbuncle, and uremia. At present, calculus bovis is artificially prepared and is called artificial calculus bovis, and the artificial calculus bovis is adopted in the embodiment.
Brief description of the experimental examples:
since 2012, a large number of clinical trials are carried out on the basis of no toxic or side effect found through toxicological experiments, and satisfactory curative effects are obtained. The following experimental cases are exemplified for only one set of recipes:
the disease condition is relieved effectively, the symptom disappears, the relapse is not found in 3 months, the disease is cured, and the disease is not relieved after the medicine is taken for two weeks. The types, the number and the treatment conditions of the lung lesions are as follows:
all experimental cases are diagnosed by the subsidiary hospital of the university of inner Mongolia, the disease condition is relieved effectively, the symptom disappears, the disease is cured after 3 months of follow-up visit, and the disease is not relieved effectively after two weeks of taking the medicine. The types, number and treatment conditions of the lesions are as follows:
effective rate = (effective number + cured number)/total number X100%, and cure rate = cured number/total number X100%.
Experiments prove that: the medicine has better treatment effect on hematemesis, hematochezia, excessive menstrual blood, traumatic hemorrhage, liver cirrhosis and other pathological changes, and has the obvious advantages of small dosage, convenient taking, low cost, low toxic and side effect and the like compared with the conventional medicine.
The second embodiment:
in the first embodiment, calcium carbonate 3-5 parts, calcium phosphate 3-5 parts and amino acid 3-5 parts are replaced by animal cutin 20-40 parts. The animal cutin 20-40 parts is preferably buffalo horn concentrated powder 20 parts or cornu Cervi 30 parts or cornu bovis Seu Bubali 40 parts or crinis Carbonisatus 25-30 parts.
Buffalo Horn, the english name Buffalo Horn, the latin name Cornu Bubali, the dihedral of a bovine animal. Cornu bubali contains cholesterol (cholestroolo), cardiotonic ingredients, peptides, horn fibers; and serine (serine), glycine (glycine), alanine (alanine), lysine (lysine), histidine (histidine), aspartic acid (aspartic acid), arginine (arginine), threonine (threonine), glutamic acid (glutamic acid), proline (proline), cystine (cystine), methionine (methionine), isoleucine (isoluteine), leucine (leucine), tyrosine (tyrosine), phenylalanine (phenylalanine), and the like. Enters heart, liver, spleen and stomach meridians. Has the effects of clearing heat, cooling blood and detoxifying. It is commonly used for fever headache, high fever coma, macula, hematemesis and epistaxis, infantile convulsion, pharyngitis and swollen throat.
Deer horn, british name "deeerhorn, Antler" latin name sika deer cervus nippon temminck or red deer c.elaphus l, wild white deer cervus maoneillydekker, white lip c.albirossprzewalski, red deer c.unicolor kerr. Chemical components: antler contains 25% of colloid, 50% -60% of calcium phosphate, calcium carbonate and nitride. Further amino acids include aspartic acid (aspartic acid), threonine (threonine), serine (serine), glutamic acid (glutamic acid), proline (proline), glycine (glycine), alanine (alanine), valine (valine), leucine (leucine), isoleucine (isoluteine), phenylalanine (phenylalanine), lysine (lysine), histidine (histidine), arginine (arginine). The pharmacological action is as follows: anti-inflammatory effects; when the n-Butanol Extract (BETA) of cornu Cervi Degelatinatum (Deerhorn antler) was administered to rat by intraperitoneal injection at a concentration of 50mg/kg, it was found that the mitochondrial monoamine oxidase (MAO) activity was significantly inhibited in liver and brain tissues of rat. In vitro experiments also demonstrated MAO inhibitory activity. 40mg/kg of antler extract can obviously increase the heart stroke amount of the halothane under light anesthesia.
The oxhorn mainly comprises oxhorn, Latin, Bostaurus domesticus Gmelin, and comprises the following main chemical components: sterols; amino acids: alanine, arginine, aspartic acid, cystine, leucine, proline, tyrosine, histidine, valine; peptides: hydrolysis of basic peptides, both of which produce arginine, lysine, histidine, glycine, alanine, proline, valine, leucine, and the like; a guanidino derivative; a protein. The properties and tastes of the herbs are bitter, salty and cold. The heart, liver and stomach meridians. The main indications are hematemesis, epistaxis, carbuncle, sore and furuncle and swelling caused by recklessly blood flow due to blood heat.
Crinis Carbonisatus, also called crinis Carbonisatus, is also processed into herbs. It is bitter, astringent, slightly warm and bitter in flavor. The main components are eukerin (eukeratin), which contains 12-15% of water, 0.3% of ash, 3.4-5.8% of fat, 17.4% of nitrogen, 5.00% of sulfur and trace elements such as calcium, potassium, iron and the like. Has hemostatic, blood stasis dispelling, diuretic, granulation promoting, toxic materials removing, and anticancer effects. The main treatment is as follows: hemorrhage due to epistaxis, stranguria with blood, hematochezia, hemoptysis, metrorrhagia, and hematuria, and dysuria due to heat and blood stasis; the external paste is used for stopping bleeding and promoting tissue regeneration, and is used for treating traumatic hemorrhage or unhealed ulcer; stopping epistaxis when blowing into nose; has anti-tumor therapeutic effect in vivo. Recent animal experiments prove that the composition can shorten the bleeding time, the blood coagulation time and the plasma recalcification time and has an adsorption effect; has inhibitory effect on Staphylococcus aureus, Salmonella typhi, Salmonella paratyphi A, and Shigella flexneri.
Among the animal cutin, buffalo horn concentrated powder and crinis Carbonisatus are commercially available products, and cornu Cervi and cornu bovis Seu Bubali are prepared by new processing method. A preferred method of processing is described below: soaking in 75% ethanol or steam sterilizing, and pulverizing into fine powder. Adding 10 times of water by weight, decocting for two times, each time for 7-10 hours, supplementing distilled water at any time in the decocting process, mixing the decoctions, filtering, concentrating the filtrate to 1-5% of the original weight, drying at the temperature of below 80 ℃, crushing into fine powder, and sieving to obtain the traditional Chinese medicine composition. Mixing with other raw materials, and making into pill, powder, unguent or capsule.
The substitution standard of the raw material medicaments is as follows:
1. the lower limit values of the effective rate and the cure rate are reduced by less than 2 percentage points compared with the first embodiment.
2. The cost of the medicine is greatly reduced after the substitution.
Experiments prove that 40 parts of buffalo horn concentrated powder, 60 parts of antler, 80 parts of ox horn or 25-30 parts of crinis carbonisatus meet the standards.
Third embodiment:
based on the second embodiment, one or more of geniposide, rutin, carthamin beta-sitosterol, emodin, glycyrrhizic acid, picrorhizin, alizarin, alkannin and cholic acid is further effectively replaced by one or more of the following raw materials:
1-2 parts of geniposide and 1-2 parts of rutin are replaced by 25-30 parts of gardenia or 25-30 parts of ruta; 1-2 parts of carthamin are replaced by 25-30 parts of safflower; 1-2 parts of beta-sitosterol are replaced by 25-30 parts of adenophora stricta; 1-2 parts of emodin are replaced by 25-30 parts of dianthus superbus; 1-2 parts of glycyrrhizic acid are replaced by 25-30 parts of liquorice; 1-2 parts of picrorhiza rhizome are replaced by 25-30 parts of picrorhiza rhizome; 1-2 parts of alizarin are replaced by 25-30 parts of madder; 1-2 parts of alkannin are replaced by 25-30 parts of lithospermum; 1-2 parts of lac resin are replaced by 25-30 parts of lacca; 1-2 parts of cholic acid is replaced by 25-30 parts of ox gall or 25-30 parts of arisaema cum bile.
Gardenia jasminoides Ellis (academic name: Gardenia jasminoides Ellis) also has the name: gardenia jasminoides Ellis, Gardenia jasminoides Ellis and Cinobufagin are fruits of Gardenia jasminoides Ellis of Rubiaceae. Containing iridoid components: geniposide (gardenoside), vicianin (geniposide), vicianin gentiobioside (genipin-1-geniobioside), shanzhiside (shanzhiside), geninone glycoside (gardo-side), paederoside methyl ester (scandoside methyl ester), vicianic acid (geniposidic acid), deacetyl asperulosidic acid (deacetyl asperulosidic acid), deacetyl asperulosidic acid methyl ester (methyl deacetyl asperuloside), 10-acetyl vicianin (10-acetylgeniposide) 6-p-coumaroyl genistein gentiobioside (6-p-coumarogenigenin-side). And acid-containing components: chlorogenic acid (chlorogenic acid), 3, 4-di-O-caffeoyl-quinic acid (3, -4-di-O-caffeoyl quinic acid), 3-O-caffeoyl-4-O-sinapoyl quinic acid (3-O-caffeoyl-4-O-silacyl quinic acid), 3, 5-di-O-caffeoyl-4-O- (3-hydroxy-3 methyl) glutaryl quinic acid [3, 5-di-O-caffeoyl-4-O- (3-hydroxy-3-methyl) glutaryl quinic acid ], 3, 4-dicaffeoyl-5- (3-hydroxy-3-methylglutaryl) quinic acid [3, 4-dicaffeovl-5- (3-hydroxy-3-methyl glutamyl) quinic acid ], crocetin (cro-cetin), crocin (crocin), ursolic acid (ursolic acid), crocin glucoside (crocin glucoside) and the like. Also contains flavonoid components: rutin (rutin), D-mannitol (D-mannitol), beta-sitosterol (beta-sitosterol), choline (choline), nonacosane (nonacosane), lutein (xanthophyll), and the like. The pericarp and seed also contain gardenoside, duciflorin acid, and duciflorin gentiobioside. The flower contains triterpene components: gardenia acid (gradenlic acid) A, B and jasmonic acid (gardenic acid) leaves contain gardenoside, ficolin, gardenia aldehyde (cerbinal), methyl dihydrojasmonate (methyl dihydrojasmonate), benzyl acetate (limone), linalool (linalool), and the like. The rhizome contains D-mannitol, oleanolic acid (oleanolic acid), and stigmasterol (sing-masterol). Bitter, cold and nontoxic in nature and taste. Has effects in purging pathogenic fire, relieving restlessness, clearing away heat, promoting urination, relieving swelling and pain, cooling blood, stopping bleeding, protecting liver, promoting function of gallbladder, lowering blood pressure, tranquilizing mind, stopping bleeding, and relieving swelling. Is commonly used for treating icteric hepatitis and headache in traditional Chinese medicine clinic; jaundice due to damp-heat; stranguria; bloody dysentery with urine; sores in the mouth and tongue; sores and ulcers with pyogenic infections; sprain and contusion, hypertension, diabetes, etc.
Ruta graveolens L (school name: Ruta graveolens L.) is a perennial herb of Rutaceae, Ruta of stem base xylem, whole herb containing acidic saponin substances, tannin, protein, mucilage, bitter substances, sugar and phenolic substances. The fresh grass contains volatile oil containing piperonyl, carene, geraniol, ethyl geranate, geranial, limonene, etc. The stems, branches and leaves are used as herbal medicines, and have the effects of clearing away heat and toxic materials, cooling blood and dissipating blood stasis. Can be used for treating common cold, fever, toothache due to pathogenic wind-fire, headache, traumatic injury, and sprain. The branches and leaves are externally applied to the skin to cause red swelling of the skin.
Safflower, a Chinese medicinal material known as Flos Carthami. Safflower is tubular corolla of Carthamus tinctorius L. Also called as Cao hong Hua, is warm in nature and pungent in flavor, and can activate blood and dredge meridians, dissipate blood stasis and alleviate pain. Can be used for treating coronary heart disease, traumatic injury, swelling and pain due to blood stasis, amenorrhea, dysmenorrhea, lochiorrhea, abdominal mass, swelling and pain due to pyocutaneous disease, and blood stasis due to hematemesis.
Adenophora stricta is also called radix Adenophorae, radix Adenophorae. According to the related information, the root of Adenophora stricta contains triterpenoid saponin and starch, and the root of Gynura procumbens contains alkaloid and abundant starch; the fruit contains Phellopterin (Phellopterin) and is separated to obtain saporin (Imperatin) and Bergapten (Bergapten), and the root fat-soluble components of various adenophora medicinal plants contain palmitoyl beta-sitosterol, lupenone, beta-sitosterol and 24-methylene-cycloartanol. Has effects in clearing away heat, nourishing yin, moistening lung, relieving cough, eliminating phlegm, tonifying heart, relieving fever, relieving pain, and resisting fungi, and can be used for treating tracheitis, pertussis, cough due to lung heat, and yellow and thick expectoration.
The fringed pink is also called as mountain fringed pink, Latin with the name of Dianthus superbus L, Caryophyllaceae and Caryophyllaceae, the fringed pink fresh grass contains crude protein, crude fiber, crude ash, phosphoric acid, vitamin A substances, and also contains alkaloids such as emodin methyl ether, emodin, 3, 4-dihydroxy methyl benzoate, 3- (3, 4-dihydroxy phenyl) methyl propionate, sitosterol glycoside and emodin-8-O-glucoside, and the whole herb is bitter in taste, cold and nontoxic. Has effects of clearing heat, promoting urination, removing blood stasis and dredging channels. Clear heat and induce diuresis, break blood and dredge meridians. It is indicated for dysuria, gonorrhea, edema, amenorrhea, carbuncle, swelling, conjunctival congestion, nebula, sores and abscess, edema, painful urination with heat and bloody stranguria.
Radix Glycyrrhizae, commonly used Chinese medicine, contains glycyrrhizin, liquiritin, licoflavonoid, semaphorin, formononetin, quercetin, etc. Has effects in clearing away toxic materials, relieving inflammation, relieving cough, resisting tumor, resisting ulcer, and inhibiting bacteria. Meanwhile, glycyrrhizin has the effect of inhibiting the proliferation of HIV. Glycyrrhetinic acid has effect in inhibiting myeloma and ascites hepatocarcinoma. Glycyrrhizic acid has obvious diuretic effect, glycyrrhizin and isoliquiritigenin have antiulcer and spasmolytic effects, and licoflavone has antioxidant and antibacterial effects.
Picrorhiza rhizome, another name: the medicinal materials include Curcuma xanthorrhiza, rhizoma picrorhizae, and Tibetan picrorhiza rhizome, which are rhizomes of Scrophulariaceae plant Tibetan picrorhiza rhizome and picrorhiza rhizome. Under the name of latin, picrorhizascophralifoliflapennell. The main components are as follows: the root contains picrorhizin (Kutkin), D-Mannitol (D-Mannitol), Vanillic acid (Vanillic acid), picrorhizin (Kutkiol), picrorhisterol (Kutkesterol) and vanillone (Apocynin), bitter constituents Picroside I (Picroside I), Picroside II and Picroside III are separated, Cinnamoyl-alpha-D-glucopyranose (Cinnamoyl-alpha-D-glucopyranose) and 6-Cinnamoyl-beta-D-glucopyranose (6-Cinnamoyl-beta-D-glucopyranose) are separated. And (4) separating the extract of the rhizoma picrorhizae to obtain apocynin (Apocynine). Rhizoma picrorhizae has effects of reducing deficiency heat, eliminating malnutritional heat, cooling blood, eliminating dampness, purging pathogenic fire and removing toxic substance, and is mainly used for treating: yin deficiency and steaming bone; tidal fever and night sweats; infantile malnutrition; dysentery due to damp-heat; jaundice; hematemesis; bleeding; conjunctival congestion with swelling and pain; carbuncle, swelling and sore; swelling and toxin of hemorrhoids.
Rubia cordifolia (scientific name: Rubia cordifolia L.) Rubiaceae, Rubia perennial climbing vine, contains alizarin and various anthraquinones and glucosides. Has the effects of cooling blood, promoting blood circulation, removing blood stasis and dredging channels. Can be used for treating hematemesis, epistaxis, metrorrhagia, traumatic hemorrhage, amenorrhea, blood stasis, arthralgia, and traumatic injury with swelling and pain. It can stop bleeding without retaining stasis, and can be used for bleeding due to heat syndrome, amenorrhea and abdominal pain, and traumatic injury. Also has antibacterial, anticancer, and therapeutic effects on lithangiuria and myocardial infarction.
Radix Arnebiae (its name is Lithospermum erythrorhizon), also called as Lithospermum erythrorhizon, Plumbum preparatium, ZIFU, despise, herba seu radix Schisandrae Bicoloris, herba Adianti, and radix Arnebiae, is a plant of Lithospermum of Boraginaceae, and has effective components: contains acetylshikonin (acetylshikonin), beta-hydroxyisovalerylshikonin (beta-hydro-isovalerylshikonin), shikonin (shikonin), beta '-dimethylacrylshikonin (beta, beta' -dimethylacrylshikonin), etc. Basic sources of medicinal materials: is root of Lithospermum erythrorhizon, Lithospermum erythrorhizon or Lithospermum erythrorhizon of Boraginaceae. Nature and taste: cold in nature, sweet and salty in flavor. Meridian tropism: it enters heart and liver meridians. And (4) efficacy classification: a hemostatic drug; blood cooling medicine; the heat-clearing and toxicity-removing herbs are mainly used for cooling blood, activating blood, removing toxicity and promoting eruption. Can be used for treating blood heat and toxic materials, macula purple black, measles without adequate eruption, pyocutaneous disease, eczema, and scald due to hot water and fire. Clearing heat and cooling blood, and can be used for treating measles, macula due to fever, eczema, hematuria, stranguria with blood, dysentery with bloody stool, pyocutaneous disease, erysipelas, burn, and constipation due to heat accumulation.
Purple grass antler, english name: shellac, Lac, latin name: the raw material Lacca Kerr, also named as Lacca: red gum, butea monosperma, purple ore, purple peduncle, lac and medicinal material base source: natural resin secreted by lacca (England) of laclaclaccidae after sap is absorbed by Lac on branches, and the mineral name of Latin plant and animal: lacca kerr. The main variety of the rod-shaped lac comprises 70-80% of resin, 6-7% of wax and 4-8% of pigment. The shellac resin can be hard or soft, wherein the hard resin accounts for 70 percent, and the pure shellac resin accounts for 10 percent. Since shellac resin is easily polymerized, there are polyesters composed mainly of 4 molecules of trienoic acid, i.e., 3 molecules of laccolic acid (jalaric acid) or epilaccolic acid (epilachallic acid) and 1 molecule of lacjiiaretic acid (lacjiiaric acid) or epilaccolic acid (epilaccicolic acid) and 4 molecules of elaeostearic acid (aleuritic acid) per molecule of shellac resin, as well as those containing 3 or 5 molecules of terpenic acid. The soft resin can be separated to obtain four pure terpene acids, namely laccijalaric acid ester (laccijalaric ester), laccijalaric acid ester (jalaric ester) I, laccijal acid ester II and laccijal acid ester II. The latter two are the raw materials for producing the hard resin. The pigment mainly contains laccaic acid A1, A2 (melting point >300 deg.), B, C, D and laccolicin (erythrolaccin). The wax is an ester of pentacosanol, dotriacontanol, eicosanoic acid, and triacontanoic acid. Sweet in taste; salty; neutral nature is in the lung; clearing heat from liver meridian; cooling the blood; and (5) detoxifying. Measles and macula are mainly obstructed; menorrhagia; (ii) metrorrhagia and metrostaxis; sores and ulcers; eczema.
The substitution is the result of screening by necessary experiments according to the components and efficacies of each raw material drug and combining with the classical literature and relevant information. Obviously, a plurality of compatible combinations can be obtained by the substitution. Because the safe dosage and compatibility limit of each raw material medicine are strictly followed, and the corresponding experimental processes are passed, the curative effects of all combinations have high consistency, and no toxic or side effect occurs. The following is only an example of one of the clinical trials with a typical combination:
25-30 parts of cape jasmine, 25-30 parts of safflower, 25-30 parts of adenophora stricta, 25-30 parts of fringed pink, 25-30 parts of liquorice, 25-30 parts of picrorhiza rhizome, 25-30 parts of madder, 25-30 parts of lithospermum, 25-30 parts of lacca, 25-30 parts of ox horn, 25-30 parts of ox gall and 25-30 parts of calculus bovis factitius.
Mixing the above materials, and making into pill, powder, unguent or capsule.
The taking method comprises the following steps: 5g for adult, and 2-3 times daily.
Since 2013, on the basis of no toxic or side effect found through toxicological experiments, a large number of clinical trials are carried out, experimental cases are diagnosed through the subsidiary hospital of the university of inner Mongolia nationality, the disease condition is relieved effectively, the symptom disappears, the relapse is not found in 3 months, the cure is realized, and the effect is not realized after the medicine is taken for two weeks. The types, number and treatment conditions of the lesions are as follows:
effective rate = (effective number + cured number)/total number X100%, and cure rate = cured number/total number X100%.
Experiments prove that: the medicine has better treatment effect on hematemesis, hematochezia, excessive menstrual blood, traumatic hemorrhage, liver bag and other pathological changes, has little difference in treatment effect compared with the first embodiment, greatly reduces the cost, and is particularly suitable for basic medical institutions or personnel.
The fourth embodiment:
based on the second embodiment, one or more of geniposide, rutin, carthamin beta-sitosterol, emodin, glycyrrhizic acid, picrorhizin, alizarin, alkannin and cholic acid is further effectively replaced by one or more of the following raw materials:
1-2 parts of geniposide and 1-2 parts of rutin are replaced by 25-30 parts of gardenia or 25-30 parts of ruta; 1-2 parts of carthamin are replaced by 25-30 parts of safflower; 1-2 parts of beta-sitosterol are replaced by 25-30 parts of pseudo-ginseng; 1-2 parts of emodin are replaced by 25-30 parts of rhubarb; 1-2 parts of glycyrrhizic acid are replaced by 25-30 parts of liquorice; 1-2 parts of picrorhiza rhizome are replaced by 25-30 parts of picrorhiza rhizome; 1-2 parts of alizarin are replaced by 25-30 parts of madder; 1-2 parts of alkannin are replaced by 25-30 parts of lithospermum; 1-2 parts of lac resin are replaced by 25-30 parts of lacca; 1-2 parts of cholic acid is replaced by 25-30 parts of one or more of sheep gall and pig gall or replaced by 25-30 parts of arisaema cum bile.
Notoginseng radix Panax Notogeneng, also known as Notoginseng radix, is a plant of Araliaceae of Umbelliferae, and contains vegetable oil, zipulol, alkyne, alkene and hydrocarbon compounds. Scientists equally obtain beta-sitosterol from root, flower and fruit of pseudo-ginseng, and the beta-sitosterol has the functions of reducing blood fat, resisting skin ulcer and the like. The alkynes olefin compound-panaxytriol (panaxytriol) is separated from the fat-soluble part of the root of the pseudo-ginseng and is the amino acid component in the pseudo-ginseng. The root part of the Chinese medicinal composition is used as a medicinal part and has the effects of removing blood stasis, stopping bleeding, reducing swelling and relieving pain. Mainly treats hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia and metrostaxis, traumatic hemorrhage, thoracico-abdominal pain and traumatic gall, and has stronger cancer prevention and anticancer effects. At present, 17 amino acids are separated from the wenshan sanchi, 7 amino acids are necessary for human bodies, and one special amino acid is named as dencichine (dencichine), so that the wenshan sanchi hemostatic effect is very good. Several rare traditional Chinese medicines of Panax genus all contain dencichine as hemostatic component, but the highest content of Panax notoginseng (0.90%), the second highest content of Panax ginseng (0.50%), and the lowest content of Panax quinquefolium (0.31%), so the hemostatic activity of Panax notoginseng is the best.
Rhubarb, named Rheum palmatum, which is another general name, is a perennial plant of various Rheum genus of Polygonaceae family, and contains Chrysophanol (Chrysophanol), Emodin (Emodin), Physcion (Physcion), Aloe-Emodin (Aloe-Emodin), Rhein (Rhein), Rhein tannins (Rhein) and related substances, such as Gallic acid (Gallic acid), catechin (tea-chicken), Rhein tetramer (Tetrarin), fatty acid, calcium oxalate, glucose, fructose, starch, and the like. The nature and flavor of the medicine are as follows: bitter and cold. Entering stomach, large intestine, liver and spleen meridians, and clearing heat and removing dampness, and can be used for treating jaundice, dysuria and constipation due to damp-heat stagnation; it also has the actions of cooling blood and stopping bleeding, and is indicated for hematemesis, epistaxis, hematochezia, metrorrhagia and metrostaxis, and leucorrhea with red and white discharge due to heat damaging blood collaterals. The modern clinic can be used for treating epidemic meningitis, lobar pneumonia, acute biliary tract infection, acute parotitis, acute appendicitis, acute infectious icterohepatitis, acute enteritis, bacillary dysentery, digestive tract hemorrhage, pharyngolaryngitis, gingival abscess, dermatitis, eczema, gonorrhea, herpes zoster, etc. Stir-baked charcoal is commonly used for cooling blood and stopping bleeding.
The following is only an example of one of the clinical trials with a typical combination:
25-30 parts of ruta, 25-30 parts of safflower, 25-30 parts of pseudo-ginseng, 25-30 parts of rhubarb, 25-30 parts of liquorice, 25-30 parts of picrorhiza rhizome, 25-30 parts of madder, 25-30 parts of lithospermum, 25-30 parts of lacca, 25-30 parts of sheep gall and pig gall with equal amount, 25-30 parts of crinis carbonisatus and 25-30 parts of calculus bovis factitius.
Mixing the above materials, and making into pill, powder, unguent or capsule.
The taking method comprises the following steps: 5g for adult, and 2-3 times daily.
Since 2014, on the basis of no toxic or side effect found in toxicological experiments, a large number of clinical trials are carried out, experimental cases are diagnosed by subsidiary hospitals of the inner Mongolia national university, the disease condition is relieved effectively, the symptom disappears, the relapse is not found in 3 months, the cure is not found, and the alleviation is not found in two weeks after the medicine is taken. The types, number and treatment conditions of the lesions are as follows:
effective rate = (effective number + cured number)/total number X100%, and cure rate = cured number/total number X100%.
Experiments prove that: the medicine has better treatment effect on hematemesis, hematochezia, excessive menstrual blood, traumatic hemorrhage, liver bag and other pathological changes, has equivalent treatment effect compared with the first embodiment, but has greatly reduced cost, and is particularly suitable for basic medical institutions or personnel.
Fifth embodiment:
based on the second embodiment, one or more of geniposide, rutin, carthamin beta-sitosterol, emodin, glycyrrhizic acid, picrorhizin, alizarin, alkannin and cholic acid is further effectively replaced by one or more of the following raw materials:
1-2 parts of geniposide and 1-2 parts of rutin are replaced by 25-30 parts of gardenia or 25-30 parts of ruta; 1-2 parts of carthamin are replaced by 25-30 parts of safflower; 1-2 parts of beta-sitosterol are replaced by 25-30 parts of adenophora stricta; 1-2 parts of emodin are replaced by 25-30 parts of dianthus superbus; 1-2 parts of glycyrrhizic acid are replaced by 25-30 parts of liquorice; 1-2 parts of picrorhiza rhizome are replaced by 25-30 parts of picrorhiza rhizome; 1-2 parts of alizarin are replaced by 25-30 parts of madder; 1-2 parts of alkannin are replaced by 25-30 parts of lithospermum; 1-2 parts of lac resin are replaced by 25-30 parts of lacca; 1-2 parts of cholic acid is replaced by 25-30 parts of arisaema cum bile. The following is only an example of one of the clinical trials with a typical combination:
25-30 parts of cape jasmine, 25-30 parts of safflower, 25-30 parts of adenophora stricta, 25-30 parts of fringed pink, 25-30 parts of liquorice, 25-30 parts of picrorhiza rhizome, 25-30 parts of madder, 25-30 parts of lithospermum, 25-30 parts of lacca, 25-30 parts of arisaema cum bile, 25-30 parts of buffalo horn concentrated powder and 25-30 parts of calculus bovis factitius.
Mixing the above materials, and making into pill, powder, unguent or capsule.
The taking method comprises the following steps: 5g for adult, and 2-3 times daily.
The arisaema cum bile is prepared by processing fine powder of arisaema cum bile and ox, sheep or pig bile or prepared by fermenting fine powder of arisaema cum bile and ox, sheep or pig bile. Bitter and cold in nature, slightly pungent and cool. It enters lung, liver and spleen meridians. Has the functions of clearing away heat, eliminating phlegm, calming endogenous wind and arresting convulsion. Can be used for treating phlegm-heat cough, yellow and thick phlegm, apoplexy with phlegm stagnation, mania, and epilepsy.
Since 2014, on the basis of no toxic or side effect found in toxicological experiments, a large number of clinical trials are carried out, experimental cases are diagnosed by subsidiary hospitals of the inner Mongolia national university, the disease condition is relieved effectively, the symptom disappears, the relapse is not found in 3 months, the cure is not found, and the alleviation is not found in two weeks after the medicine is taken. The types, number and treatment conditions of the lesions are as follows:
effective rate = (effective number + cured number)/total number X100%, and cure rate = cured number/total number X100%.
Experiments prove that: the medicine has better treatment effect on hematemesis, hematochezia, excessive menstrual blood, traumatic hemorrhage, liver bag and other pathological changes, has little difference in treatment effect compared with the first embodiment, greatly reduces the cost, and is particularly suitable for basic medical institutions or personnel.
Sixth embodiment:
on the basis of the second embodiment, the third embodiment, the fourth embodiment or the fifth embodiment, 25 to 30 parts of trogopterus dung, 25 to 30 parts of palm ash and 25 to 30 parts of agrimony are added into the raw material medicine.
Oletum Trogopterori, Faeces Trogopterori, also known as herb, Hanhao feces, and Oletum Trogopterori, is divided into two kinds of Oletum Trogopterori rice and Oletum Trogopterori block (blood Oletum Trogopterori and sugar Oletum Trogopterori). The Lingzhi rice is the dry excrement of compound-tooth squirrel, and the Lingzhi blocks are the mixture of excrement and urine mixed with small amount of sandstone for drying and coagulation. Contains vitamin A substances, resin, urea, uric acid, etc. And contains catechol, benzoic acid, 3-carene-9, 10 dicarboxylic acid, uracil, m-hydroxybenzoic acid, protocatechuic acid, hypoxanthine, allantoin, L-tyrosine, and 5-methoxy-7-hydroxycoumarin. Oletum Trogopterori is effective in promoting blood circulation and removing blood stasis, and can be used for treating hemorrhage due to blood stasis and non-meridian invasion, such as metrorrhagia, metrostaxis, and lower abdomen stabbing pain.
Palm, British name PETIOLUS TRACHYCARPI, also known as Brown hair, is neutral in nature and taste, astringent and bitter, and enters large intestine meridian, lung meridian and liver meridian. Astringent hemostatics belong to the category of hemostatics. The functional indications are as follows: astringe to stop bleeding, stop dysentery and stop leucorrhea.
Agrimonia pilosa Ledeb, also called Agrimonia pilosa and Dioscorea villosa, is a generic name of perennial herbs of the genus Agrimonia of the family Rosaceae, especially, European Agrimonia pilosa. The whole plant contains agrimonine, agrimonolide, tannin (such as pyrocatechol tannin and gallotannin), sterol, organic acid, phenolic component, and saponin. The root contained tannin 8.9%, the stem contained tannin 6.5%, and the leaf contained tannin 16.4%. The stem and leaf also contain luteolin-7-beta-glucoside and apigenin-7-beta-glucoside. The whole herb, root and winter bud of agrimony are important medicinal materials. Has hemostatic, heart strengthening, body strengthening, dysentery relieving, and antiinflammatory effects. Can be used for treating asthenia, menoxenia, metrorrhagia, leucorrhea, stomach cold, abdominal pain, dysentery, hematemesis, hemoptysis, intestinal wind, hematuria, metrorrhagia, and duodenal hemorrhage.
The following experimental conditions are exemplified for only one of the combinations:
25-30 parts of ruta graveolens, 25-30 parts of safflower, 25-30 parts of pseudo-ginseng, 25-30 parts of rheum officinale, 25-30 parts of liquorice, 25-30 parts of rhizoma picrorhizae, 25-30 parts of madder, 25-30 parts of lithospermum, 25-30 parts of lacca, 25-30 parts of sheep gall and pig gall with equal amount, 25-30 parts of crinis carbonisatus, 25-30 parts of artificial bezoar, 25-30 parts of trogopterus dung, 25-30 parts of palm ash and 25-30 parts of agrimony.
Pulverizing herba Cymbopogonis, Carthami flos, Notoginseng radix, radix et rhizoma Rhei, Glycyrrhrizae radix, rhizoma picrorhizae, radix Rubiae, radix Arnebiae, Lacca, crinis Carbonisatus, Oletum Trogopterori, palm ash, and herba Agrimoniae, sieving with 60 mesh sieve, mixing with other raw materials, and making into watered pill.
Mixing the above materials, and making into pill, powder, unguent or capsule.
The taking method comprises the following steps: the medicine is taken at a dose of 6g for an adult and 2-3 times daily.
Since 2015, on the basis of no toxic or side effect found through toxicology experiments, a large number of clinical trials are carried out, experimental cases are diagnosed and confirmed through a hospital affiliated to the university of inner Mongolia nationality, the disease condition is relieved effectively, the symptom disappears, the disease is cured after 3 months of follow-up visit, and the disease is not relieved after two weeks of taking the medicine. The types, number and treatment conditions of the lesions are as follows:
effective rate = (effective number + cured number)/total number X100%, and cure rate = cured number/total number X100%.
Experiments prove that: the medicine has better treatment effect on hematemesis, hematochezia, excessive menstrual blood, traumatic hemorrhage, liver bag and other pathological changes, has equivalent treatment effect compared with the first embodiment, but has greatly reduced cost, and is particularly suitable for basic medical institutions or personnel.
The seventh embodiment:
on the basis of the previous embodiment, the processing method of the medicine is improved. Pulverizing fructus Gardeniae, Carthami flos, Notoginseng radix or radix Adenophorae, herba Dianthi or radix et rhizoma Rhei, Glycyrrhrizae radix, rhizoma picrorhizae, radix Rubiae, radix Arnebiae, and Lacca, sieving with 80 mesh sieve, mixing, extracting with 70% ethanol for 30-60 min, and recovering ethanol under reduced pressure; extracting with ethyl acetate for 30-60 min, recovering solvent, concentrating, pulverizing, sieving with 60 mesh sieve, mixing with other raw materials, and making into pill, powder, ointment or capsule.
The curative effect of the medicine prepared by the process is slightly improved, but the significant effect time is greatly shortened by over 30 percent on average.
The following illustrates only one comparative experiment:
the experimental prescription is as follows: 25-30 parts of cape jasmine, 25-30 parts of safflower, 25-30 parts of adenophora stricta, 25-30 parts of fringed pink, 25-30 parts of liquorice, 25-30 parts of picrorhiza rhizome, 25-30 parts of madder, 25-30 parts of lithospermum, 25-30 parts of lacca, 25-30 parts of ox horn, 25-30 parts of ox gall and 25-30 parts of calculus bovis factitius.
Control group: mixing the above materials, and making into pill. The taking method comprises the following steps: 5g for adult, and 2-3 times daily. All experimental cases are diagnosed by the subsidiary hospital of the university of inner Mongolia, the disease condition is relieved effectively, the symptom disappears, the disease is cured after 3 months of follow-up visit, and the disease is not relieved effectively after two weeks of taking the medicine. The types, number and treatment conditions of the lesions are as follows:
experimental groups: pulverizing fructus Gardeniae, Carthami flos, Notoginseng radix or radix Adenophorae, herba Dianthi, Glycyrrhrizae radix, rhizoma picrorhizae, radix Rubiae, radix Arnebiae, and Lacca, sieving with 80 mesh sieve, mixing, extracting with 70% ethanol for 30-60 min, and recovering ethanol under reduced pressure; extracting with ethyl acetate for 30-60 min, recovering solvent, concentrating to dry powder, sieving with 60 mesh sieve, mixing with other raw materials, and making into pill. The taking method comprises the following steps: 5g for adult, and 2-3 times daily. All experimental cases are diagnosed by the subsidiary hospital of the university of inner Mongolia, the disease condition is relieved effectively, the symptom disappears, the disease is cured after 3 months of follow-up visit, and the disease is not relieved effectively after two weeks of taking the medicine. The types, number and treatment conditions of the lesions are as follows:
the main indexes are compared as follows:
the above table shows that: the effective rate and the cure rate of the experimental group are higher than those of the experimental group, but the range is not large. The significant effect time and the cure time are greatly shortened, and the clinical significance is very obvious.
Claims (6)
1. A Mongolian medicine for clearing heat and stopping bleeding is characterized in that: the Mongolian medicine is prepared from the following raw material medicines in parts by weight: 1-2 parts of geniposide, 1-2 parts of rutin, 1-2 parts of carthamin, 1-2 parts of beta-sitosterol, 1-2 parts of emodin, 1-2 parts of glycyrrhizic acid, 1-2 parts of kutkin, 1-2 parts of alizarin, 1-2 parts of alkannin, 1-2 parts of shellac resin, 3-5 parts of calcium carbonate, 3-5 parts of calcium phosphate, 3-5 parts of amino acid, 2-3 parts of cholic acid and 2-3 parts of bezoar.
2. A Mongolian medicine for clearing heat and stopping bleeding is characterized in that: the Mongolian medicine is prepared from the following raw material medicines in parts by weight: 25-30 parts of cape jasmine, 25-30 parts of safflower, 25-30 parts of adenophora stricta, 25-30 parts of fringed pink, 25-30 parts of liquorice, 25-30 parts of picrorhiza rhizome, 25-30 parts of madder, 25-30 parts of lithospermum, 25-30 parts of lacca, 25-30 parts of ox horn, 25-30 parts of ox gall and 25-30 parts of calculus bovis factitius.
3. A Mongolian medicine for clearing heat and stopping bleeding is characterized in that: the Mongolian medicine is prepared from the following raw material medicines in parts by weight: 25-30 parts of ruta, 25-30 parts of safflower, 25-30 parts of pseudo-ginseng, 25-30 parts of rhubarb, 25-30 parts of liquorice, 25-30 parts of picrorhiza rhizome, 25-30 parts of madder, 25-30 parts of lithospermum, 25-30 parts of lacca, 25-30 parts of sheep gall and pig gall with equal amount, 25-30 parts of crinis carbonisatus and 25-30 parts of calculus bovis factitius.
4. A Mongolian medicine for clearing heat and stopping bleeding is characterized in that: the Mongolian medicine is prepared from the following raw material medicines in parts by weight: 25-30 parts of cape jasmine, 25-30 parts of safflower, 25-30 parts of adenophora stricta, 25-30 parts of fringed pink, 25-30 parts of liquorice, 25-30 parts of picrorhiza rhizome, 25-30 parts of madder, 25-30 parts of lithospermum, 25-30 parts of lacca, 25-30 parts of arisaema cum bile, 25-30 parts of buffalo horn concentrated powder and 25-30 parts of calculus bovis factitius.
5. A Mongolian medicine for clearing heat and stopping bleeding is characterized in that: the Mongolian medicine is prepared from the following raw material medicines in parts by weight: 25-30 parts of ruta graveolens, 25-30 parts of safflower, 25-30 parts of pseudo-ginseng, 25-30 parts of rheum officinale, 25-30 parts of liquorice, 25-30 parts of rhizoma picrorhizae, 25-30 parts of madder, 25-30 parts of lithospermum, 25-30 parts of lacca, 25-30 parts of sheep gall and pig gall with equal amount, 25-30 parts of crinis carbonisatus, 25-30 parts of artificial bezoar, 25-30 parts of trogopterus dung, 25-30 parts of palm ash and 25-30 parts of agrimony.
6. The process for preparing a Mongolian medicine for clearing heat and stopping bleeding as claimed in claim 2 or 4, wherein: pulverizing fructus Gardeniae, Carthami flos, radix Adenophorae, herba Dianthi, Glycyrrhrizae radix, rhizoma picrorhizae, radix Rubiae, radix Arnebiae, and Lacca, sieving with 80 mesh sieve, mixing, extracting with 70% ethanol for 30-60 min, and recovering ethanol under reduced pressure; extracting with ethyl acetate for 30-60 min, recovering solvent, concentrating, pulverizing, sieving with 60 mesh sieve, mixing with other raw materials, and making into pill, powder, paste or capsule.
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| CN109771414B (en) * | 2019-03-15 | 2021-04-20 | 苏州大学附属第二医院 | Pharmaceutical composition for treating hemorrhagic shock |
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| 生血康对特发性血小板减少性紫癜患者骨髓巨核细胞的影响;龚翠琴等;《内蒙古民族大学学报(自然科学版)》;20060228;第21卷(第01期);78-79 * |
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