CN107582899A - The anaesthetic and its manufacturing process of a kind of clearing away heat to stop bleeding - Google Patents
The anaesthetic and its manufacturing process of a kind of clearing away heat to stop bleeding Download PDFInfo
- Publication number
- CN107582899A CN107582899A CN201710988652.4A CN201710988652A CN107582899A CN 107582899 A CN107582899 A CN 107582899A CN 201710988652 A CN201710988652 A CN 201710988652A CN 107582899 A CN107582899 A CN 107582899A
- Authority
- CN
- China
- Prior art keywords
- parts
- acid
- anaesthetic
- blood
- clearing away
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The present invention relates to a kind of medicine and its manufacturing process, i.e., the anaesthetic and its manufacturing process of a kind of clearing away heat to stop bleeding, it is characterised in that：The anaesthetic includes the bulk drug of following parts by weight：1-2 parts of gardenoside, 1-2 parts of rutin, 1-2 parts of carthamin; 1-2 parts of Sitosterolum, 1-2 parts of rheum emodin, 1-2 parts of glycyrrhizic acid; 1-2 parts of kutkin, 1-2 parts of rubican, 1-2 parts of alkannin; 1-2 parts of lac resin; 3-5 parts of calcium carbonate, 3-5 parts of calcium phosphate, 3-5 parts of amino acid; 2-3 parts of cholic acid, 2-3 parts of cow-bezoar.Beneficial effect is：With clearing heat and cooling blood anastalsis, to spitting blood, having blood in stool, menorrhagia, traumatism and bleeding, liver bag such as haemorrhage there is significant curative effect, and toxic side effect is low, the crowd of being applicable scope is wide, is easy to take, is easy to digest and assimilate, markedly fast, it is expected to as the typical medicaments of pneumotherapy.
Description
Technical field
The present invention relates to a kind of medicine and preparation method, i.e., the anaesthetic and its manufacturing process of a kind of clearing away heat to stop bleeding.
Background technology
Mongolian medicine is for spitting blood, having blood in stool, menorrhagia, traumatism and bleeding, liver bag such as haemorrhage have original treatment method,
Used anaesthetic is more based on removing heat from the liver, removing heat from blood, to hold back purulence blood, antiemetic as assistant, forms a variety of prescriptions.Although above-mentioned anaesthetic
The treatment works well, but due to lacking modem technology, the mechanism of action of medicine is relatively fuzzyyer, and active ingredient is more uncertain,
And processed using ancient method, active ingredient and invalid components mix, and dosage is big, and effective slow, toxic side effect is strong, not housecoat
With inconvenience storage is transported, and limits the utilization of anaesthetic.
The content of the invention
It is an object of the invention to provide one kind to spitting blood, having blood in stool, menses are more, traumatism and bleeding, liver bag such as lesion have it is aobvious
Curative effect is write, and the mechanism of action is clear and definite, invalid components are greatly decreased, and dosage is small, and markedly fast, toxic side effect is low, are easy to take, are easy to
The clearing away heat to stop bleeding anaesthetic of accumulating and the manufacturing process of this medicine.
Above-mentioned purpose is realized by following technical scheme：A kind of anaesthetic of clearing away heat to stop bleeding, is characterized in：The anaesthetic bag
Include the bulk drug of following parts by weight：1-2 parts of gardenoside, 1-2 parts of rutin, 1-2 parts of carthamin, 1-2 parts of cupreol, greatly
1-2 parts of flavine, 1-2 parts of glycyrrhizic acid, 1-2 parts of kutkin, 1-2 parts of rubican, 1-2 parts of alkannin, lac resin 1-2
Part, 3-5 parts of calcium carbonate, 3-5 parts of calcium phosphate, 3-5 parts of amino acid, 2-3 parts of cholic acid, 2-3 parts of cow-bezoar.
3-5 parts of the calcium carbonate, 3-5 parts of calcium phosphate, 20-40 parts with animal cutin of 3-5 parts of amino acid substitute.
20-80 parts of the animal cutin is included more than 20 parts of PULVIS CORNUS BUBALI CONCEN TRATUS or 30 parts of deer horn or 40 parts of ox horn or blood
25-30 parts.
The gardenoside, rutin, carthamin cupreol, rheum emodin, glycyrrhizic acid, kutkin, rubican, Asian puccoon
It is one or more respectively with a kind of following or plurality of raw materials medicine replacement among element, cholic acid：1-2 parts of gardenoside, rutin 1-2
Part is substituted with 25-30 parts of 25-30 parts of cape jasmine or rue；25-30 parts with safflower of 1-2 parts of carthamin substitutes；Cupreol 1-
2 parts are substituted with 25-30 parts of 25-30 parts of the root of straight ladybell or pseudo-ginseng；1-2 parts of rheum emodin 25-30 parts of 25-30 parts of fringed pink or rheum officinale
Substitute；25-30 parts with radix glycyrrhizae of 1-2 parts of glycyrrhizic acid substitutes；25-30 parts with Radix picrorrhizae of 1-2 parts of kutkin substitutes；Rubican
1-2 parts with 25-30 parts of madder replacement；25-30 parts with Asian puccoon of 1-2 parts of alkannin substitutes；1-2 parts of lac resin uses Asian puccoon
Fine and soft 25-30 parts of replacements；1-2 parts of cholic acid substituted with 25-30 parts of one or more of ox courage, sheep courage, pig gall or with arisaema cum bile 25-
30 parts of replacements.
The bulk drug adds one or more of 25-30 parts of excrementum pteropi, 25-30 parts of palm ash, 25-30 parts of hairyvein agrimony.
The anaesthetic includes the bulk drug of following parts by weight：25-30 parts of rue, 25-30 parts of safflower, pseudo-ginseng 25-30
Part, 25-30 parts of rheum officinale, 25-30 parts of radix glycyrrhizae, 25-30 parts of Radix picrorrhizae, 25-30 parts of madder, 25-30 parts of Asian puccoon, shellac
25-30 parts, totally 25-30 parts of the sheep courage of equivalent, pig gall, blood more than 25-30 parts, 25-30 parts of calculus bovis factitius, excrementum pteropi 25-30
Part, 25-30 parts of palm ash, 25-30 parts of hairyvein agrimony.
The ox horn, the processing method of deer horn are with after the immersion of 75% ethanol or steam disinfection, are ground into fine powder；Add 10 times
Weight water decocts twice, 7~10 hours every time, supplements the moisture boiled off in decoction process at any time；Collecting decoction, filtration, filtrate
1-the 5% of original weight amount is concentrated into, after being dried below 80 DEG C, is ground into fine powder, sieves, produces；Mix, make with other bulk drugs
The formulations such as pelletization, scattered, cream or capsule.
The cape jasmine, safflower, pseudo-ginseng or the root of straight ladybell, fringed pink or rheum officinale, radix glycyrrhizae, Radix picrorrhizae, madder, Asian puccoon, shellac are beaten
Powder is crossed more than 80 mesh and sieved, after mixing with more than 70% alcohol steep 30-60 minutes, ethanol is recovered under reduced pressure；Ethyl acetate is used again
Extraction 30-60 minutes, crushings is concentrated to dryness after recycling design, more than 60 mesh of mistake sieves, is mixed with other bulk drugs, be made ball,
The formulation such as scattered, cream or capsule.
The beneficial effects of the invention are as follows：With clearing heat and cooling blood anastalsis, to spitting blood, having blood in stool, menorrhagia, wound go out
Blood, liver bag such as haemorrhage have significant curative effect, and toxic side effect is low, and applicable crowd's scope is wide, is easy to take, and is easy to digestion to inhale
Receive, markedly fast, it is expected to as the typical medicaments of pneumotherapy.
Embodiment
The first embodiment：
A kind of anaesthetic of clearing away heat to stop bleeding is developed, includes the bulk drug of following parts by weight：1-2 parts of gardenoside, 1-2 parts of rutin,
1-2 parts of carthamin, 1-2 parts of cupreol, 1-2 parts of rheum emodin, 1-2 parts of glycyrrhizic acid, 1-2 parts of kutkin, rubican
1-2 parts, 1-2 parts of alkannin, 1-2 parts of lac resin, 3-5 parts of calcium carbonate, 3-5 parts of calcium phosphate, 3-5 parts of amino acid, courage
2-3 parts of acid, 2-3 parts of cow-bezoar.
Each bulk drug is mixed, the formulations such as ball, scattered, cream or capsule are made.
Instructions of taking：Adult 1-2g/ times, takes 2-3 day.
Bulk drug brief introduction：
Gardenoside, English name：Gardenoside, alias：Gardenoside, cape jasmine glucoside, gardenoside, molecular formula
C17H24O11, category sugar and glucoside, have laxative, analgesia, cholagogic, anti-inflammatory, treatment soft tissue injury and suppress gastric secretion and
Reduce the effect such as amylopsin.
Rutin, also known as：Rutin Rutin, citrin, rutin, Rutoside, Violaquereitrin,
Molecular formula C27H30O163H2O1, there is anti-inflammatory, antiviral, maintenance vascular resistance, reduce its permeability, reduce fragility etc.
Effect, clinic are used for treating burn, arthritis, the increased capillary hemorrhage disease of fragility and various vascular diseases, Yi Jigao
The auxiliary treatment of blood pressure diseases, to prevent cerebral hemorrhage；It can also be used for treatment of vascular purpura disease, acute hemorrhagic ephritis, diabetes
Retinal hemorrhage, recidivity nosebleed, traumatic empsyxis, puerperal hemorrhage etc..
Carthamin, it is the class of Chinese medicine II, freeze-dried, it is a kind of water-soluble flavone class compound extracted from safflower, pharmacodynamics
Documents and materials are reported:Safflower is known as reduction coronary resistance, increases the effect of coronary flow and myocardial nutrition.Carthamin can reduce rabbit
The scope and degree of Myocardial Infarction, improve damage and necrotic type ECG Change.Pharmacodynamic study shows, carthamin 7-
28mg/kg can significantly inhibit the rise of dog arteria coroaria sinistra caused by ligature EECG ST sections, reduce the release of serum acid kinase, contracting
Myocardial infarct area.Carthamin has obvious effect to Rat Experimental thrombosis and platelet aggregation.
Rheum emodin, alias：9,10-Anthracenedione,1,3,8-thihydroxy-6-methyl, English name：Emodin, chemical name：1'3'8- trihydroxy -6- tectoquinones,
Molecular formula：C15H10O5, rheum emodin can be used as cathartic, and glycoside is combined into sugar, then discharge function is more preferably.It is another have antibacterial, cough-relieving,
Antitumor, hypotensive etc. acts on.Rheum emodin has antitumor, antibacterial, strengthen immunity, cardiac stimulant, hypotensive, cough-relieving, diuresis, rushed down
Under, cholagogic, spasmolysis, the enhancing effect such as immunologic function.
Cupreol, English:Sitosterol, alias:Beta- sitosterol, phytosterol, (3 β)-beans steroid -5- alkene -3-
Alcohol, sitosterol, sitosterol, Sitosterolum.Molecular formula C29H50O.Sterol is a kind of material for having physiologically active, can be promoted for medicine
Enter wound healing, make hypertrophy, strengthen capillary circulation.Sitosterol is nontoxic, non-stimulated to skin, has significant anti-inflammatory
Function, available for treatment cutaneum carcinoma and skin ulcer, and there are norcholesterol, cough-relieving, eliminating the phlegm, the work for suppressing tumour and repair tissue
With.For hypercholesterolemia, atherosclerosis and chronic bronchitis, also for pre-term cervical cancer and skin ulcer
Deng.
Glycyrrhizic acid, Radix Glycyrrhizae, alias:Glycyrrhizin, molecular formula:C42H62O16, it is most main in radix glycyrrhizae
The active component wanted.Medicine be used for kobadrin, gastric ulcer, acute or chronic gastritis, eczema, pruitus, hepatitis, hyperlipidemia,
Papillomavirus, conjunctivitis, and for treating cancer and preventing and treating AIDS, have inhibitory action to sarcoma, growth of cancer cells, to Chinese mugwort
The inhibiting rate for growing disease is more up to 90%, there is stronger increase immune function of human body effect.
Alkannin, English name shikonin, different name shikonin, shikonin, d-alkanin, common name：5,8- dihydroxy -2-
[the amyl- 3- alkenyls of (1R) -1- hydroxy-4-methyls] naphthalene-Isosorbide-5-Nitrae-diketone, molecular formula C16H16O5, is a kind of crystalline powder, exists
In comfrey Asian puccoon (Lithosperraum erythrorhizon Sieb. et Zucc.) root, lithospermum euchromum Royle
In plants such as [Arnebia euchroma (Royle) Johnst].Also Asian puccoon (Lithosperrnum can be used
Erythrorhizon Sieb. et Zuce.) cell culture production alkannin.Acted on anticancer, anti-inflammatory, antibacterial etc..Face
Bed is used to treat acute hepatitis, chronic hepatitis, hepatic sclerosis (ascites).Pi Gan sections are used to treat flat wart, psoriasis, and topical application treatment is burnt
Wound and promotion wound healing.Eye drops is used to treat herpes simplex keratitis, to epitheliated type dendroid and shallow essential layer branch
Shape keratitis has certain curative effect.Finish is used to treat infant dermatitis, eczema, vaginitis, cervicitis etc..Toothpaste containing this product
Tooth dental caries and gingivitis can be prevented and treated.
Lac resin, it is Lacciferidae insect lac insect（English name Shellac, Lac）The natural tree secreted on branch
Main active in fat, accounts for 5-the 6% of natural resin, and its molecular weight is about 2194, and per molecule is average by four molecule terpenes
［ i.e. three molecule jalaric acids (jalaric acid) or epishellolic acid (epishellolic acid) and a molecule are purple for olefin(e) acid
Careless fine and soft sour (laccijalaricacid) or table epilaccishellolic acid (epilaccishellolic acid) ］ and four molecule tung oil trees
Sour (aleuritic acid) is formed.Factually test, lac resin have clearing heat and detoxicating, cooling and activating blood, clearing damp desinsection, cool blood,
The effect of removing toxic substances.
Kutkin is the stable mixed crystal of Radix picrorrhizae hardship glucoside I (Picroside I) and kutkin (Kutkoside), more
It is present in the rhizome of goatweed Tibet picrorhiza rhizome and Radix picrorrhizae.It is demonstrated experimentally that kutkin is the main effective of Radix picrorrhizae
Composition, there is reducing the asthenic fever, the infantile malnutrition due to digestive disturbances or intestinalparasites that disappears heat, heat-clearing and damp-drying drug, purging intense heat and detonicating effect, to deficiency of Yin hectic fever due to yin, hectic fever night sweat, infant malnutrition, wet
The tools such as hot rush down dysentery, jaundice, haematemesis, bleeding from five sense organs or subcutaneous tissue, red eye, swell pain, carbuncle swells sore, hemorrhoid pyogenic infections have the effect of good.
Rubican, English name:Alizarin, alias name:1,2- dihydroxy -9,10- amerantrone 1,2- hydroxy-anthraquiones
Alizarin 1,2- dihydroxy 1,2- dihydroxy castor quinones, molecular formula:C14H8O4, growth of the rubican to staphylococcus aureus have
Inhibitory action, the permeability of rat skin connective tissue can be suppressed, there is the antiinflammatory action similar to rutin.
Calcium carbonate Calcium carbonate, molecular formula:CaCO3.Precipitated calcium carbonate can be used as leavening agent, flour processing
Agent, anticaking agent, acidity regulator, nutrition fortifier, curing agent etc..China provides to can be used for the varieties of food items that need to add swelling agent
And chewing gum base, by GMP.Flour improver is can also be used for, maximum usage amount is 0.03%；7.5~18g/kg of milk powder；Soymilk
Powder, 4~20g/kg of bean powder；0.4~3.4g/kg of soft drink；6~8g/kg of lotus root starch；2~7g/kg of instant breakfast cereal products.FDA
（184.1192,2000）Being limited property does not provide, by GMP.It is more when this product makees leavening agent use to be used cooperatively with other kinds, with
The leavening agent that the compoundings such as sodium acid carbonate, alum obtain, heat then slowly disengage carbon dioxide, produce food uniform, fine and smooth
Bulk body, the quality of cake, bread, biscuit can be improved.In addition with the effect for strengthening calcium, the smaller easier suction of calcium carbonate granule
Receive.In Japan, precipitated calcium carbonate is used as leavening agent, and dosage is 1% in normal food.Also act as feed nutrition hardening agent.Carbonic acid
Calcium is the main component of anaesthetic calcite, has clear bar up to xeothermic, antiemetic, antidiarrheal, help digestion, detoxify, broken ruffian, callus, synthetism are adjusted
Member and other effects.
Calcium phosphate calcium phosphate, tribasic, molecular formula (Ca3 (PO4) 2), insoluble in ethanol and acetone,
Water is slightly soluble in, is soluble in watery hydrochloric acid and nitric acid.It may be used as anticaking agent, acidity regulator, nutritional supplement, fumet, stably
Agent, water retention agent.It is used as anticaking agent, acidity regulator, nutritional supplement, fumet, stabilizer, moisture in the food industry
Retention agent.China《Food additives use sanitary standard》(GB2760-2011) provide：Calcium phosphate can be used for wheat flour, maximum
Usage amount is 0.03g/kg；Solid beverage 8.0g/kg；Potato chips 2.0g/kg.It can be used for as water retention agent in flour.
FAO/WHO is provided：As anticaking agent can be used for glucose powder, cane sugar powder, research on maximum utilized quantity be 15g/kg (individually or with other anticaking agents
Share, in the absence of starch)；Milk powder, dry cream, (shared individually or with other stabilizers, in terms of anhydride) for 5g/kg；For
During automatic vending machine, milk powder, 10g/kg, dry cream 1g/kg (are shared individually or with other anticaking agents);Soup and custard, 15mg/kg
(sharing individually or with stearate and silica, refer to dehydrating prods)；Cocoa power and containing sugared cocoa power, 10g/kg (individually or
Shared with other anticaking agents, automatic vending machine is only used for containing sugared cocoa power).As stabilizer etc. can be used for evaporated milk, condensed milk,
Dilute cream, dosage is 2g/kg (alone), 3g/kg (being shared with other stabilizers), in terms of anhydride.It is for processing cheese
9g/kg (total phosphate, in terms of phosphorus).This product is still used as calcium constituent hardening agent, and for biscuit, bread etc., its dosage is to cereal
Powder is 3g/kg, solid beverage 20g/kg, in terms of element calcium.Calcium phosphate is the animals such as Mongolian medicine's conventional crude drugs deer, ox, sheep, pig
The main component of bone, have detoxify, calm the nerves, be anticonvulsion, strengthening body etc. acts on.
The amino acid (amino acid) is the common name of a kind of organic compound containing amino and carboxyl, macromolecular egg
The basic composition unit of white matter, it is the base substance for forming protein needed for Animal nutrition.The species of amino acid is a lot, this example institute
State amino acid include lysine, alanine, arginine, aspartic acid, cystine, leucine, proline, tyrosine, histidine,
Valine.
Cholic acid, English name:3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid;
CAS:81-25-4 Chinese nicknames:3alpha, 7alpha, 12alpha- trihydroxy -5beta- cholanic acids;Cholic acid;Ring spore
Element;The hydroxyl steroids of 3,17,12- tri- are for isovaleric acid;Anhydrous cholic acid;3,7,12- trihydroxy cholestanics;Cholic acid;Three hydroxyl cholane
Acid;The Β cholanic acids of trihydroxy -5, molecular formula:C24H40O5.This product is present in the bile of ox, sheep, pig.Cholic acid is closed by liver
Into being drained into bile in duodenum, one of part as digestive juice, the digestion and suction to lipid material can be promoted
Receive.Cholate is grease emulsifier, and the hydrolysis and absorption of grease are helped in intestines.Cholic acid also has antispastic, stomach invigorating, reduced in blood
Cholesterol content etc. acts on.
Cow-bezoar Bos taurus domesticus Gmelin are called that western yellow, rhinoceros is yellow, ugly treasured, are Chordata Mammalias
The gall stone of bovid cattle liver.Containing cholic acid 5% -11%, deoxycholic aicd about 2%, chenodeoxycholic acid 0.6% -1.7% and its salt
Class, bilirubin (bilirubin) and its calcium salt, and containing cholesterine, ergosterol, lecithin, aliphatic acid, vitamin D, water solubility
Peptide constituents SMC, Yi Jitong, iron, magnesium, zinc etc..Australia's production cow-bezoar is containing carotenoid, alanine, glycine, taurine
(taurine), the several amino acids such as asparatate, arginine, leucine, methionine.Traditional Chinese medicine thinks cow-bezoar gas delicate fragrance, taste
Slight bitter then sweet tea, it is cool in nature.Available for heat-clearing, removing toxic substances, arresting convulsion.Internal treatment of high fever is delirious, demented, child convulsion, twitch etc.
Abscess of throat, aphtha carbuncle swells, uremia etc. are controlled in disease, external application.Cow-bezoar is manually produced at present, referred to as calculus bovis factitius, and this example is adopted
Manually cow-bezoar.
Experimental example brief introduction：
Since 2012, on the basis of toxic side effect is not found by toxicological experiment, substantial amounts of clinic trial is carried out, has been taken
Obtained the effect of being satisfied with.The experimental conditions of one group of prescription are only exemplified by below：
Disease amelioration is effective, and for 3 months no relapse of symptom disappearance follow-up to cure, medication has no that mitigation is invalid for two weeks.Lung
Portion's lesion species, number of cases and treatment such as following table：
Experiment case is made a definite diagnosis by Affiliated Hospital of Inner Mongolia University for the Nationalities's diagnosis, and disease amelioration is effective, symptom disappearance follow-up 3
For individual month no relapse to cure, medication has no that mitigation is invalid for two weeks.Lesion species, number of cases and treatment such as following table：
Efficient=（Significant figure+healing number）/ total number X 100%, cure rate=healing number/total number X 100%.
Experiment proves：This medicine is for spitting blood, having blood in stool, menses are more, traumatism and bleeding, liver bag such as lesion have and preferably controlled
Therapeutic effect, have dosage small compared with conventional medicine, be easy to take, cost is low, and toxic side effect is low to wait clear superiority.
Second of embodiment：
On the basis of the first embodiment, 3-5 parts of calcium carbonate, 3-5 parts of calcium phosphate, 3-5 parts of amino acid animal cutin
20-40 parts of replacements.20 parts of the preferred PULVIS CORNUS BUBALI CONCEN TRATUS of 20-40 parts of the animal cutin or 30 parts of deer horn or 40 parts of ox horn or blood
Remaining 25-30 parts.
Cornu bubali, English name Buffalo Horn, Latin literary fame Cornu Bubali, double angles of bovid buffalo.Water
Ox horn (cholesterolo) containing cholesterine, cardiac stimulant composition, peptides, angle fiber；And serine (serine), glycine
(glycine), alanine (alanine), lysine (lysine), histidine (histidine), aspartic acid (aspartic
Acid), arginine (arginine), threonine (threonine), glutamic acid (glutamic acid), proline
(proline), cystine (cystine), methionine (methionine), isoleucine (isoleucine), leucine
(leucine) several amino acids such as, tyrosine (tyrosine), phenylalanine (phenylalanine), it is bitter in taste salty, tremble with fear, nothing
Poison.Enter the heart, liver, spleen, stomach four to pass through.The effect of with heat-clearing, cool blood, removing toxic substances.It is usually used in controlling pyreticosis headache, high fever coma, macula,
Hematemesis, child convulsion, larynx numbness pharynx swelling.
Deer horn, English name " Deerhorn, Antler " latin name sika deer CervusnipponTemminck or red deer
C.elaphusL, wild white deer CervusmaoneilliLydekker, white lip C.AlbirostrisPrzewalski, red deer
C.unicolorKerr.Chemical analysis：Deer horn contains colloid 25%, calcium phosphate 50%-60%, calcium carbonate and nitride.Separately contain amino
Acid, inside there is aspartic acid（aspartic acid）, threonine（threonine）, serine（serine）, glutamic acid
（glutamic acid）, proline（proline）, glycine（glycine）, alanine（alanine）, valine
（valine）, leucine（leucine）, isoleucine（isoleucine）, phenylalanine（phenylalanine）, lysine
（lysine）, histidine（histidine）, arginine（arginine）.Pharmacological action：Antiinflammatory action；Crinosity deer horn n-butanol
Extract（BETA）50mg/kg intraperitoneal injections award rat, it is seen that the monoamine oxidase of rats'liver and brain tissue Mitochondria
（MAO）Activity is substantially suppressed.Experiment in vitro also proves to have to MAO inhibitory activity.Cornu Cervi extract 40mg/kg, fluorine can be made
Alkane light anesthesia dog cardiac output substantially increases.
Ox horn, mainly ox angle, latin name:Bostaurus domesticus Gmelin, main chemical compositions：Steroid
Alcohols；Amino acid：Alanine, arginine, aspartic acid, cystine, leucine, proline, tyrosine, histidine, valine；
Peptides：The hydrolysis of alkaline peptides, both produce arginine, lysine, histidine, glycine, alanine, proline, valine,
Leucine etc.；Guanidine derivative；Protein.Meridian distribution of property and flavor:It is bitter, salty, tremble with fear.The heart, liver, stomach three pass through.Cure mainly:For blood-heat bleeding
Spit blood, bleeding from five sense organs or subcutaneous tissue, ulcerative carbuncle furuncle.
More than blood, also known as human hair, process patent medicine and be also known as carbonized hair.Its property of medicine bitterness tepor, bitter.Main component is a kind of excellent
Keratin (eukeratin), moisture content 12%-15%, ash content 0.3%, fatty 3.4%-5.8%, nitrogen 17.4%, sulphur 5.00% and calcium,
The trace elements such as potassium, iron.There is a hemostasis dispersing blood stasis, diuresis myogenic, the effect of internal heat anticance.Cure mainly：Bleeding from five sense organs or subcutaneous tissue, blood strangury, have blood in stool, spit blood,
A variety of bleedings such as uterine bleeding and hemostasis hold thermal conductivity under the arm and cause urinary obstruction, thirsty, lower abdominal distention pain or blood urine；Cream hemostasia and promoting granulation is endured in external application,
Control traumatic bleeding or unhealing ulcer；Bleeding from five sense organs or subcutaneous tissue can be stopped in nasal insufflation；Show antitumor therapeutic action in vivo.Recent zoopery card
It is bright, bleeding, blood coagulation and plasma recalcification time can be shortened, and have suction-operated；To staphylococcus aureus, typhoid fever bar healthy hair
Bacterium, paratyphoid bacillus A and shigella flexneri etc. have inhibitory action.
Among above-mentioned animal cutin, commercially available product is belonged to more than PULVIS CORNUS BUBALI CONCEN TRATUS and blood, and deer horn, ox horn are then needed using new
Processing method produce.A kind of preferable processing method is described below：After the immersion of 75% ethanol or steam disinfection, it is ground into thin
Powder.Add 10 times of weight waters to decoct twice, 7~10 hours every time, supplement the moisture boiled off in decoction process at any time, collecting decoction,
Filtration, filtrate are concentrated into 1-the 5% of original weight amount, after being dried below 80 DEG C, are ground into fine powder, sieve, produce.With other raw materials
Medicine mixes, and the formulations such as ball, scattered, cream or capsule are made.
Bulk drug alternate standard：
1. efficient and cure rate lower limit range of decrease compared with the first embodiment is less than 2 percentage points.
2. cost of drugs declines to a great extent after substituting.
It the experiment proved that, 60 parts of 40 parts of PULVIS CORNUS BUBALI CONCEN TRATUS or deer horn or 80 parts of ox horn or blood more than 25-30 parts, meet
Above-mentioned standard.
The third embodiment：
On the basis of second of embodiment, further gardenoside, rutin, carthamin cupreol, rheum emodin, radix glycyrrhizae
Acid, kutkin, rubican, alkannin, one or more among cholic acid enter the trade with a kind of following or plurality of raw materials medicine imitates
Substitute：
1-2 parts of gardenoside, 1-2 parts of rutin are substituted with 25-30 parts of 25-30 parts of cape jasmine or rue；1-2 parts of use of carthamin
25-30 parts of replacements of safflower；25-30 parts with the root of straight ladybell of 1-2 parts of cupreol substitutes；1-2 portions of rheum emodin, 25-30 parts of fringed pink
Substitute；25-30 parts with radix glycyrrhizae of 1-2 parts of glycyrrhizic acid substitutes；25-30 parts with Radix picrorrhizae of 1-2 parts of kutkin substitutes；Rubican
1-2 parts with 25-30 parts of madder replacement；25-30 parts with Asian puccoon of 1-2 parts of alkannin substitutes；1-2 parts of lac resin uses Asian puccoon
Fine and soft 25-30 parts of replacements；1-2 parts of cholic acid substitutes for 25-30 parts with 25-30 parts of replacements of ox courage or with arisaema cum bile.
Cape jasmine（Scientific name：Gardenia jasminoides Ellis）Alias：Yellow Fructus Gardeniae, mountain Cape jasmine, white toad, it is that Rubiaceae is planted
The fruit of thing cape jasmine.Constituents containing iridoid：Gardenoside (gardenoside), all square rafter glucoside (geniposide), square rafter
Plain gentiobiose glucoside (genipin-1-gentiobioside), shanzhiside (shanzhiside), cape jasmine ketone glucoside (gardo-
Side), Chinese Fevervine Herb time glucoside methyl esters (scandoside methyl ester), all square rafter glucoside (geniposidic acid), goes
Acetyl group asperuloside acid (deacetyl asperulosidic acid), deacetylasperulosidic acid methyl esters (methyl
Deacetyl asperulosidate), the 〃 of 10- acetyl group all square rafter glucoside (10-acetylgeniposide) 6-to coumaric acyl
All square rafter (6 〃-p-coumaroyl genipin gentiobio-side).Contain acrylic component again：Green original
Sour (chlorogenic acid), its quininic acid (3, -4-di-O-caffeoyl quinic acid) of 3,4- bis--O- caffeoyls,
3-O- coffee acyl -4-O- mustard acyls quininic acid (3-O-caffeoyl-4-O-sinapoyl quinic acid), 3,5-
Two-O- coffee acyls -4-O- (methyl of 3- hydroxyls -3) glutaryl quininic acid [3,5-di-O-caffeoyl-4-O- (3-
Hydroxy-3-methyl) glutaroyl quinic acid], 3,4- bis- coffee acyl -5- (3- hydroxy-3-methyl glutaryls
Base) quininic acid [3,4-dicaffeovl-5- (3-hydroxy-3-methyl glutaroyl) quinic acid], safflower
Sour (cro-cetin), crocin (crocin), ursolic acid (ursolic acid), crocin glycoside (crocin
Glucoside) etc..Also contain flavones ingredient：Rutin (rutin) and PEARLITOL 25C (D-mannitol), cupreol (β-
Sitosterol), choline (choline), nonacosane (nonacosane), lutein (xanthophyll) etc..Pericarp and kind
Also containing gardenoside, all square rafter glucoside, all square rafter glucoside, all square rafter in son.Flower contains Triterpenoid：Gardenia acid
(gradenlic acid) A, B and gardenia acid (gardenic acid) leaf contain gardenoside, all square rafter glucoside, cape jasmine aldehyde
(cerbinal), MDJ (methyl dihydrojasmonate), acetic acid benzyl lemon imonene (limonene), fragrant camphor tree
Alcohol (linalool) etc..Rhizome contains PEARLITOL 25C, oleanolic acid (oleanolic acid), stigmasterol (sing-masterol).
It is bitter in taste, cold, nontoxic.With purging intense heat relieving restlessness, reducing fever and causing diuresis, swelling and pain relieving, cooling blood and hemostasis, protect liver, cholagogic, decompression, calmness, only
Blood, detumescence etc. act on.It is usually used in treating icteric hepatitis, headache in tcm clinical practice；Jaundice with damp-heat pathogen；Stranguria；Bloody flux hematuria；Dispute
Raw sore；Sore swollen toxin；The diseases such as bruise, hypertension, diabetes.
Rue (scientific name:Ruta graveolensL.):The wooden herbaceos perennial of Rutaceae, rue category basal part of stem,
Herb is containing acid saponins, tannin, protein, mucilaginous substance, amaroid, carbohydrate and phenolic substance.Fresh grass contains volatile oil, waves
Containing piperitone, carene, Geraniol, Mang Ethylgeranate in hair oil, still there are Mang geranial, limonene etc..Stem branch and Ye Junyong
Make herbal medicine, there is the effect of clearing heat and detoxicating, cool blood dissipates the stasis of blood.Cure mainly cold, fever, acute toothache, headache, bruises and sprains.Branches and leaves external application
Wipe skin and cause red swelling of the skin.
Safflower, Chinese medicine scientific name Flos Carthami.(English) Safflower, it is feverfew safflower Carthamus
Tinctorius L. tubular corolla.Also known as safflower, warm-natured, acrid flavour, invigorate blood circulation, blood stasis removing analgesic.For coronary heart disease, fall
Beat damage, blood stasis and swelling pain, Amenorrhea, dysmenorrhoea, lochia, abdominal mass lump in the abdomen, sore swell and ache curative and haematemesis and have the stagnant person of the stasis of blood.
The root of straight ladybell Adenophora stricta alias:Adenophora tetraphylla, bubble ginseng, bubble the root of straight ladybell.According to relevant information, the root of adenophora tetraphylla
In the root containing triterpenoid saponin and starch glehnia littoralises containing alkaloid, abundant starch；Fruit contains phellopterin
（Phellopterin）, and analyse to obtain osthole（Imperatorin）, bergapten（Bergapten）, various Lady bell medicines
With containing palmityl cupreol, lupenone, cupreol and 24- methylene-ring in the root liposoluble constituent of plant
A Erting alcohol the root of straight ladybell is sweet;Slight bitter;Cold nature;Return lung;Stomach.Can clearing heat and nourishing yin, moisten the lung and relieve the cough, have eliminating the phlegm, cardiac stimulant, solution
The effect such as heat, analgesia, antimycotic, is usually used in treating tracheitis, pertussis, cough with lung heat, cough up phlegm yellow thick.
Fringed pink, alias:High mountain fringed pink, Latin literary fame:Dianthus superbus L. Caryophyllaceaes, Carnation are perennial
Draft, fringed pink fresh grass containing thick protein, crude fibre, coarse ash, phosphoric acid, also material containing retinoid, still containing Physcion,
Rheum emodin, 3,4- methyl dihydroxy benzoates, 3- (3,4- dihydroxy phenyls) methyl propionate, anthemisol and rheum emodin -8-O-
The alkaloids such as glucoside, all herbal medicine,:Bitter, tremble with fear, it is nontoxic.There are heat-clearing, diuresis, blood-breaking to stimulate the menstrual flow effect.Clearing away heat and promoting diuresis, break
Blood stimulates the menstrual flow.Control urinary obstruction, gonorrhoea, oedema, Amenorrhea, carbuncle swells, hot eyes hides from view, sore of contaminating, harness the river swollen, the puckery pain of urine heat, blood strangury.
Radix glycyrrhizae Radix Glycyrrhizae, conventional Chinese medicine, its main component:Glycyrrhizin, liquiritin, radix glycyrrhizae class are yellow
Ketone, rear curtain are than wingceltis element, formoononetin, Quercetin etc..With removing toxic substances, anti-inflammatory, antibechic, antitumor, antiulcer, antibacterial etc. are made
With.Meanwhile glycyrrhizin has Inhibit proliferaton effect to AIDS virus.Enoxolone has suppression to myeloma and Example Ascites hepatoma
Make and use.Glycyrrhizic acid has obvious antidiuretic activity, and glycyrrhizin, isoliquiritigenin have antiulcer and spasmolysis, radix glycyrrhizae Huang
Ketone still has antioxygen and bacteriostasis.
Radix picrorrhizae, alias：Lonely dew pool, Hu Lian, Tibet picrorhiza rhizome are cut, is goatweed Tibet picrorhiza rhizome and Radix picrorrhizae
Rhizome.Latin name PicrorhizascrophulariifloraPennell.Main component：Root contains kutkin（Kutkin）、
D-mannital（D-Mannitol）, vanillic acid（Vanillic acid）, kutkinol（Kutkiol）, kutkisterol
（Kutkisterol）And acetovanilone（Apocynin）, still isolate to obtain bitter principle kutkin I（PicrosideⅠ）、
Piperonyl methyl acetone, the of kutkin III still analyse to obtain cinnamoyl-α-D- glucopyranoses（Cinnamoyl-α-D-
glucopyranose）And 6- cinnamoyl-β-D- glucopyranoses（6-Cinnamoyl- β-D-gluco- pyranose）.It is recklessly yellow
Acetovanillone is analysed to obtain in abstract even（Apocynine）.Radix picrorrhizae has reducing the asthenic fever, the infantile malnutrition due to digestive disturbances or intestinalparasites that disappears heat, cool blood eliminating dampness, purging intense heat and detonicating
Effect, cure mainly：Deficiency of Yin hectic fever due to yin；Hectic fever night sweat；Infant malnutrition；Damp-heat dysentery；Jaundice；Spit blood；Bleeding from five sense organs or subcutaneous tissue；Red eye, swell pain；Carbuncle swells sore
Ulcer；Hemorrhoid pyogenic infections.
Madder (scientific name:Rubia cordifolia L.):Rubiaceae, the perennial herbaceous stem of Rubia climbs up by holding on to rattan wood, containing madder
Plain (alizarin) and a variety of Anthraquinones, glycoside constituents.With cooling and activating blood, dissolving stasis, the effect of stimulating the menstrual flow.For telling
Blood, bleeding from five sense organs or subcutaneous tissue, metrostaxis, traumatism and bleeding, Amenorrhea stasis blocking, joint pain, tumbling and swelling.This product is stopped blooding without staying the stasis of blood, can be used for
Heat symptom-complex bleeding, Amenorrhea stomachache, traumatic injury.Also there is antibacterial, anticancer and the therapeutic action to lithangiuria, myocardial infarction.
Asian puccoon (scientific name:Lithospermum erythrorhizon), alias mountain Asian puccoon, Zi Dan, purple cottonrose hibiscus, it is small, blood, crow
Rank grass, alkanet, are Boraginaceae puccoons, active ingredient：Containing Acetylshikonin（acetylshikonin）, beta-hydroxy it is different
Valeryl alkannin（β-hydro-xyisovalerylshikonin）, alkannin（shikonin）, β, β '-dimethyl allene acyl it is purple
Careless element（β, β '-dimethylacrylshikonin）Deng.Medicine elementary source：It is purple for comfrey Asian puccoon, Xinjiang-Tibet vacation Asian puccoon or Yunnan
The root of grass.Nature and flavor：It is cold in nature, it is sweet, salty.Channel tropism：The thoughts of returning home, Liver Channel.Effect is classified：Hemostatic；Blood-cooling drugs；Heat-clearing and detoxifying drug function
Cool blood is cured mainly, is invigorated blood circulation, promoting eruption of detoxifying.For blood-heat and toxin exuberance, atropurpureus macula, measles without adequate eruption, sore, eczema, scald.Heat-clearing
Cool blood, for measles, pyreticosis ecchymosis, eczema, hematuria, blood strangury, bloody flux, sore, erysipelas, burn, constipation with heat retention.
Shellac, English name：Shellac, Lac, latin name：Medicinal material Lacca original animal Laccifer lacca
Kerr. alias：Red glue, palas, Zi Kuang, lac encrusted twig, lac, shellac, medicine elementary source：For Lacciferidae insect lac insect【English
Name】Shellac, Lac draw the natural resin secreted out of after resin, Latin plant animal mineral name on branch：Laccifer
lacca Kerr..The bar-shaped shellac of its main kind resinous 70%-80%, wax 6%-7%, pigment 4%-8%.Lac resin can divide
Firmly, soft two kinds, animi resin accounts for 70%, wherein pure lac resin accounts for 10%.Because lac resin easily polymerize, therefore per molecule lac resin
Mainly by 4 molecule circle olefin(e) acids, i.e., by 3 his sub- jalaric acids（jalaric acid）Or epishellolic acid（epishellolic
acid）With 1 molecule shellac acid（laccjialaric acid）Or table epilaccishellolic acid（epilaqccishellolic
acid）With 4 molecule aleuritic acids（aleuritic acid）The polyester formed, also have containing 3 molecules or 5 molecule terpenic acids.It is soft
Resin he from four kinds of pure terpenic acids, i.e. laccijaaric ester（laccijalaric ester）, jalaric ester
（jalaric ester）I, laccijaaric ester II and jalaric ester II.Both are the raw material for production animi resin afterwards.Pigment
Main red acid containing shellac（laccaic acid）A1、A2（Fusing point>300°）, B, C, D and erythrolaccin（erythrolaccin）.
The ester that wax is made up of pentacosyl alcohol, laccerol and 20 acid, lacceroic acid.It is sweet；It is salty；Mild-natured return lung；Liver Channel heat-clearing；It is cool
Blood；Removing toxic substances.Djumah rash, macula are impermeable；Menorrhalgia；Uterine bleeding；Sore；Eczema.
Above-mentioned replacement is the composition and effect according to each bulk drug, with reference to ancient books and records document and relevant information, and by must
The experiment wanted and the result screened.Obviously, above-mentioned replacement can obtain multiple compatibility combinations.Due to following strictly each original
Expect safety using amount and the compatibility limitation of medicine, and by corresponding experimentation, the effect of each combination with height one
Cause property, and do not occur toxic side effect.Being only exemplified by one of them below has the clinical trial situation of typical combination：
25-30 parts of cape jasmine, 25-30 parts of safflower, 25-30 parts of the root of straight ladybell, 25-30 parts of fringed pink, 25-30 parts of radix glycyrrhizae, Radix picrorrhizae
25-30 parts, 25-30 parts of madder, 25-30 parts of Asian puccoon, 25-30 parts of shellac, 25-30 parts of ox horn, 25-30 parts of ox courage,
25-30 parts of calculus bovis factitius.
Each bulk drug is mixed, the formulations such as ball, scattered, cream or capsule are made.
Instructions of taking：Adult 5g/ times, takes 2-3 day.
Since 2013, on the basis of toxic side effect is not found by toxicological experiment, substantial amounts of clinic trial has been carried out,
Experiment case is made a definite diagnosis by Affiliated Hospital of Inner Mongolia University for the Nationalities's diagnosis, and disease amelioration is effective, symptom disappearance follow-up 3 months
For no relapse to cure, medication has no that mitigation is invalid for two weeks.Lesion species, number of cases and treatment such as following table：
Efficient=（Significant figure+healing number）/ total number X 100%, cure rate=healing number/total number X 100%.
Experiment proves：This medicine is for spitting blood, having blood in stool, menses are more, traumatism and bleeding, liver bag such as lesion have and preferably controlled
Therapeutic effect, therapeutic effect is more or less the same compared with the first embodiment, but its cost is greatly reduced, particularly suitable for primary care machine
Structure or librarian use.
4th kind of embodiment：
On the basis of second of embodiment, further gardenoside, rutin, carthamin cupreol, rheum emodin, radix glycyrrhizae
Acid, kutkin, rubican, alkannin, one or more among cholic acid enter the trade with a kind of following or plurality of raw materials medicine imitates
Substitute：
1-2 parts of gardenoside, 1-2 parts of rutin are substituted with 25-30 parts of 25-30 parts of cape jasmine or rue；1-2 parts of use of carthamin
25-30 parts of replacements of safflower；25-30 parts with pseudo-ginseng of 1-2 parts of cupreol substitutes；1-2 parts of rheum emodin, 25-30 parts of rheum officinale
Substitute；25-30 parts with radix glycyrrhizae of 1-2 parts of glycyrrhizic acid substitutes；25-30 parts with Radix picrorrhizae of 1-2 parts of kutkin substitutes；Rubican
1-2 parts with 25-30 parts of madder replacement；25-30 parts with Asian puccoon of 1-2 parts of alkannin substitutes；1-2 parts of lac resin uses Asian puccoon
Fine and soft 25-30 parts of replacements；1-2 parts of cholic acid is substituted with 25-30 parts of one or more of sheep courage, pig gall or with 25-30 parts of arisaema cum bile
Substitute.
Pseudo-ginseng Panax Notoginseng, also known as pseudo-ginseng, be Umbellales Araliaceae, containing vegetable fat, black alcohol and
Alkynes, alkene, hydrocarbon compound.Scientist has got the black alcohol of β-paddy from Roots of Panax Notoginseng, flower, fruit, has reducing blood lipid and anti-skin
Ulcer etc. acts on.From the isolated ene-alkyne hydrocarbon compound-panaxytiol of the fatty contents of Roots of Panax Notoginseng
（panaxytriol）, the compound is the aminoacid ingredient in pseudo-ginseng.Its root has dissipate stasis of blood hemostasis, disappeared as medicinal effects
The effect of swollen analgesic therapy.Cure mainly spitting of blood, spit blood, bleeding from five sense organs or subcutaneous tissue, have blood in stool, uterine bleeding, traumatism and bleeding, chest and abdomen shouting pain, fall servant swelling and pain, and with compared with
Strong anti-cancer and antitumaous effect.At present, 17 kinds of amino acid are separated in mountain of papers pseudo-ginseng, it is that body body is required there are 7 kinds, wherein there is one kind
Special acid is referred to as dencichine (dencichine), has extraordinary anastalsis.Several rare Chinese medicines of Panax are equal
Containing hemostatic compositions dencichine, but with pseudo-ginseng content highest (0.90%), ginseng takes second place (0.50%), and American Ginseng is minimum (0.31%),
Therefore, the styptic activity of pseudo-ginseng is best.
Rheum officinale, RheumpalmatumL, nickname general, be a variety of polygonaceae Rheums perennial plant, contain Chrysophanol
（Chrysophanol）, rheum emodin（Emodin）, Physcion（Physcion）, aloe-emodin（Aloe-emodin）, it is big
Yellow acid（Rhein）, rheotannic acid（Rheum tannic acids）And its related substances, such as gallic acid（Gallic acid）、
Cachou extract（Cate- chin）, tetrarin（Tetrarin）, aliphatic acid, calcium oxalate, glucose, fruit sugar and starch etc..Enter
Property of medicine taste：Hardship, tremble with fear.Return stomach, large intestine channel, Liver Channel, the spleen channel, can removing damp-heat, for the jaundice of stagnation of damp-heat, difficult urination,
Dry and hard excrement；Also can cooling blood and hemostasis, for the haematemesis of injury of blood collaterals by heat, bleeding from five sense organs or subcutaneous tissue, have blood in stool, uterine bleeding, leukorrhea with reddish discharge.Modern clinic can use
It is yellow in treatment epidemic meningitis, lobar pneumonia, acute biliary infection, acute parotidits, acute appendicitis, acute infective
Subcutaneous ulcer type hepatitis, chordapsus, bacillary dysentery, hemorrhage of digestive tract, sphagitis, parulis, dermatitis, eczema, gonorrhoea, banding blister
Rash etc..Fry charcoal and be usually used in cooling blood and hemostasis.
Being only exemplified by one of them below has the clinical trial situation of typical combination：
25-30 parts of rue, 25-30 parts of safflower, 25-30 parts of pseudo-ginseng, 25-30 parts of rheum officinale, 25-30 parts of radix glycyrrhizae, Radix picrorrhizae
25-30 parts, 25-30 parts of madder, 25-30 parts of Asian puccoon, 25-30 parts of shellac, totally 25-30 parts of the sheep courage of equivalent, pig gall,
Blood mores than 25-30 parts, 25-30 parts of calculus bovis factitius.
Each bulk drug is mixed, the formulations such as ball, scattered, cream or capsule are made.
Instructions of taking：Adult 5g/ times, takes 2-3 day.
Since 2014, on the basis of toxic side effect is not found by toxicological experiment, substantial amounts of clinic trial has been carried out,
Experiment case is made a definite diagnosis by Affiliated Hospital of Inner Mongolia University for the Nationalities's diagnosis, and disease amelioration is effective, symptom disappearance follow-up 3 months
For no relapse to cure, medication has no that mitigation is invalid for two weeks.Lesion species, number of cases and treatment such as following table：
Efficient=（Significant figure+healing number）/ total number X 100%, cure rate=healing number/total number X 100%.
Experiment proves：This medicine is for spitting blood, having blood in stool, menses are more, traumatism and bleeding, liver bag such as lesion have and preferably controlled
Therapeutic effect, therapeutic effect is suitable compared with the first embodiment, but its cost is greatly reduced, particularly suitable for basic medical unit or
Librarian use.
5th kind of embodiment：
On the basis of second of embodiment, further gardenoside, rutin, carthamin cupreol, rheum emodin, radix glycyrrhizae
Acid, kutkin, rubican, alkannin, one or more among cholic acid enter the trade with a kind of following or plurality of raw materials medicine imitates
Substitute：
1-2 parts of gardenoside, 1-2 parts of rutin are substituted with 25-30 parts of 25-30 parts of cape jasmine or rue；1-2 parts of use of carthamin
25-30 parts of replacements of safflower；25-30 parts with the root of straight ladybell of 1-2 parts of cupreol substitutes；1-2 portions of rheum emodin, 25-30 parts of fringed pink
Substitute；25-30 parts with radix glycyrrhizae of 1-2 parts of glycyrrhizic acid substitutes；25-30 parts with Radix picrorrhizae of 1-2 parts of kutkin substitutes；Rubican
1-2 parts with 25-30 parts of madder replacement；25-30 parts with Asian puccoon of 1-2 parts of alkannin substitutes；1-2 parts of lac resin uses Asian puccoon
Fine and soft 25-30 parts of replacements；25-30 parts with arisaema cum bile of 1-2 parts of cholic acid substitutes.Being only exemplified by one of them below has typical combination
Clinical trial situation：
25-30 parts of cape jasmine, 25-30 parts of safflower, 25-30 parts of the root of straight ladybell, 25-30 parts of fringed pink, 25-30 parts of radix glycyrrhizae, Radix picrorrhizae
25-30 parts, 25-30 parts of madder, 25-30 parts of Asian puccoon, 25-30 parts of shellac, 25-30 parts of arisaema cum bile, PULVIS CORNUS BUBALI CONCEN TRATUS
25-30 parts, 25-30 parts of calculus bovis factitius.
Each bulk drug is mixed, the formulations such as ball, scattered, cream or capsule are made.
Instructions of taking：Adult 5g/ times, takes 2-3 day.
Arisaema cum bile processes from strand for the fine powder of Rhizoma Arisaematis (processed) with ox, sheep or pig's bile, or for unprocessed Arisaema erubescens fine powder and ox,
Sheep or pig's bile is fermented is process.Taste bitter and cold, micro-pungent, it is cool.Return lung, liver, the spleen channel.With clearing heat and eliminating phlegm, dispelling wind and relieving convulsion
Function.For phlegm-heat cough, cough up phlegm yellow thick, middle wind phlegm fan, demented frightened epilepsy.
Since 2014, on the basis of toxic side effect is not found by toxicological experiment, substantial amounts of clinic trial has been carried out,
Experiment case is made a definite diagnosis by Affiliated Hospital of Inner Mongolia University for the Nationalities's diagnosis, and disease amelioration is effective, symptom disappearance follow-up 3 months
For no relapse to cure, medication has no that mitigation is invalid for two weeks.Lesion species, number of cases and treatment such as following table：
Efficient=（Significant figure+healing number）/ total number X 100%, cure rate=healing number/total number X 100%.
Experiment proves：This medicine is for spitting blood, having blood in stool, menses are more, traumatism and bleeding, liver bag such as lesion have and preferably controlled
Therapeutic effect, therapeutic effect is more or less the same compared with the first embodiment, but its cost is greatly reduced, particularly suitable for primary care machine
Structure or librarian use.
6th kind of embodiment：
On the basis of second of embodiment or the third embodiment or the 4th kind of embodiment or the 5th kind of embodiment, the raw material
Medicine adds one or more of 25-30 parts of excrementum pteropi, 25-30 parts of palm ash, 25-30 parts of hairyvein agrimony.
Excrementum pteropi, Faeces Trogopterori, also known as medicine sheet, cold number frass, clever fat etc., are divided into clever fat rice, clever fat block
Two kinds of (blood spirit fat, the clever fat of sugar).Clever fat rice is the drying excrement of trogopterus xanthipes Milne-Edwards, and clever fat block is its excrement and the mixture folder of urine
Condensation is dried with a small amount of sandstone to form.Material containing retinoid, resin, urea, uric acid etc..And containing catechol, benzoic acid,
3- carenes -9,10 dicarboxylic acids, uracil, m-hydroxybenzoic acid, protocatechuic acid, hypoxanthine, allantoin, TYR, separately contain
5- methoxyl groups-umbelliferone.Excrementum pteropi is drug for invigorating blood circulation and eliminating stasis, available for blood-stasis internal-depression, such as bleeding of the escape of blood from vessels and channels, women
Uterine bleeding passes through more, color purple polylith, stabbing pain of the lower abdomen.
Palm, English name PETIOLUS TRACHYCARPI, alias palm fiber, nature and flavor are put down, puckery, bitter, return large intestine channel, lung channel,
Liver Channel.Belong to the astringent hemostatic of hemostatic subordinate classification.Major function：Astringing to arrest bleeding, stop dysentery stop-band.
Hairyvein agrimony Agrimonia pilosa Ledeb, also known as hairyvein agrimony, celestial grass, belong to perennial for rose family hairyvein agrimony
Herbal common name, espespecially Agrimonia eupatoria.Herb is containing agrimonine, agrimonolide, tannin（For Jiao's property catechol tan
Matter, alkaloid etc.）, sterol, organic acid, phenolic constituent, saponin etc..Root contains tannin 8.9%, and stem contains tannin 6.5%, and leaf contains tan
Matter 16.4%.Stem, the leaf also -7- containing cyanidenon β-glycoside and apiolin -7- β-glycoside.The herb of hairyvein agrimony, root and
Hibernaculum is important medicinal material.With there is hemostasis, cardiac stimulant is strong, stop dysentery and anti-inflammatory and other effects.It is tired available for treatment Zhi Tuoli,
Menoxenia, it is red to collapse leukorrhea, stomach cold stomachache, dysentery, spit blood, spitting of blood, intestines wind, hematuria, uterine hemorrhage, duodenum
The diseases such as bleeding.
A kind of experimental conditions of compatibility therein are only exemplified by below：
25-30 parts of rue, 25-30 parts of safflower, 25-30 parts of pseudo-ginseng, 25-30 parts of rheum officinale, 25-30 parts of radix glycyrrhizae, Radix picrorrhizae
25-30 parts, 25-30 parts of madder, 25-30 parts of Asian puccoon, 25-30 parts of shellac, totally 25-30 parts of the sheep courage of equivalent, pig gall,
Blood mores than 25-30 parts, 25-30 parts of calculus bovis factitius, 25-30 parts of excrementum pteropi, 25-30 parts of palm ash, 25-30 parts of hairyvein agrimony.
Rue, safflower, pseudo-ginseng, rheum officinale, radix glycyrrhizae, Radix picrorrhizae, madder, Asian puccoon, shellac, blood are remaining, excrementum pteropi, palm ash,
Hairyvein agrimony, which beats powder and crossed more than 60 mesh, sieves, and is mixed with other bulk drugs, breaks into the water-bindered pill.
Each bulk drug is mixed, the formulations such as ball, scattered, cream or capsule are made.
Instructions of taking：Adult 6g/ times, takes 2-3 day.
Since 2015, on the basis of toxic side effect is not found by toxicological experiment, substantial amounts of clinic trial has been carried out,
Experiment case is made a definite diagnosis by Affiliated Hospital of Inner Mongolia University for the Nationalities's diagnosis, and disease amelioration is effective, symptom disappearance follow-up 3 months
For no relapse to cure, medication has no that mitigation is invalid for two weeks.Lesion species, number of cases and treatment such as following table：
Efficient=（Significant figure+healing number）/ total number X 100%, cure rate=healing number/total number X 100%.
Experiment proves：This medicine is for spitting blood, having blood in stool, menses are more, traumatism and bleeding, liver bag such as lesion have and preferably controlled
Therapeutic effect, therapeutic effect is suitable compared with the first embodiment, but its cost is greatly reduced, particularly suitable for basic medical unit or
Librarian use.
7th kind of embodiment：
On the basis of previous embodiment, the processing method of medicine is improved.Cape jasmine, safflower, pseudo-ginseng or the root of straight ladybell, fringed pink
Or rheum officinale, radix glycyrrhizae, Radix picrorrhizae, madder, Asian puccoon, shellac are beaten powder and crossed more than 80 mesh and sieve, soaked after mixing with more than 70% ethanol
Carry 30-60 minutes, ethanol is recovered under reduced pressure；Extracted 30-60 minutes with ethyl acetate again, crushing be concentrated to dryness after recycling design,
Cross more than 60 mesh and sieve, mixed with other bulk drugs, the formulations such as ball, scattered, cream or capsule are made.
Slightly improved on year-on-year basis using the pharmaceutical effectiveness of above-mentioned technique, but its effective time significantly shortens, and averagely shortens 30%
More than.
A contrast experiment is only exemplified by below：
Test prescription：25-30 parts of cape jasmine, 25-30 parts of safflower, 25-30 parts of the root of straight ladybell, 25-30 parts of fringed pink, radix glycyrrhizae 25-30
Part, 25-30 parts of Radix picrorrhizae, 25-30 parts of madder, 25-30 parts of Asian puccoon, 25-30 parts of shellac, 25-30 parts of ox horn, ox courage
25-30 parts, 25-30 parts of calculus bovis factitius.
Control group：Each bulk drug is mixed, pill is made.Instructions of taking：Adult 5g/ times, takes 2-3 day.Test case
Made a definite diagnosis by Affiliated Hospital of Inner Mongolia University for the Nationalities's diagnosis, disease amelioration is effective, symptom disappearance 3 months no relapse of follow-up
To cure, medication has no that mitigation is invalid for two weeks.Lesion species, number of cases and treatment such as following table：
Experimental group：Cape jasmine, safflower, pseudo-ginseng or the root of straight ladybell, fringed pink, radix glycyrrhizae, Radix picrorrhizae, madder, Asian puccoon, shellac are beaten powder and cross 80
More than mesh sieve, after mixing with more than 70% alcohol steep 30-60 minutes, ethanol is recovered under reduced pressure；Extracted again with ethyl acetate
30-60 minutes, crushing is concentrated to dryness after recycling design, crosses more than 60 mesh and sieves, mixed with other bulk drugs, pill is made.Take
Method：Adult 5g/ times, takes 2-3 day.Experiment case is made a definite diagnosis by Affiliated Hospital of Inner Mongolia University for the Nationalities's diagnosis, and the state of an illness is delayed
Solve to be effective, for 3 months no relapse of symptom disappearance follow-up to cure, medication has no that mitigation is invalid for two weeks.Lesion species, number of cases
And treatment such as following table：
Leading indicator contrast is as follows：
Upper table is visible：The effective percentage and cure rate of experimental group are above experimental group, but amplitude is little.And when effective time and healing
Between but significantly shorten, its clinical meaning is very notable.
Claims (8)
- A kind of 1. anaesthetic of clearing away heat to stop bleeding, it is characterised in that：The anaesthetic includes the bulk drug of following parts by weight：Gardenoside 1-2 Part, 1-2 parts of rutin, 1-2 parts of carthamin, 1-2 parts of cupreol, 1-2 parts of rheum emodin, 1-2 parts of glycyrrhizic acid, Radix picrorrhizae 1-2 parts of element, 1-2 parts of rubican, 1-2 parts of alkannin, 1-2 parts of lac resin, 3-5 parts of calcium carbonate, 3-5 parts of calcium phosphate, 3-5 parts of amino acid, 2-3 parts of cholic acid, 2-3 parts of cow-bezoar.
- 2. the anaesthetic of clearing away heat to stop bleeding according to claim 1, it is characterised in that：3-5 parts of the calcium carbonate, calcium phosphate 3-5 Part, 20-40 parts with animal cutin of 3-5 parts of amino acid substitutes.
- 3. the anaesthetic of clearing away heat to stop bleeding according to claim 2, it is characterised in that：20-80 parts of the animal cutin includes buffalo Angle concentrates 30 parts of 20 parts of powder or deer horn or 40 parts of ox horn or blood mores than 25-30 parts.
- 4. the anaesthetic of clearing away heat to stop bleeding according to claim 1, it is characterised in that：The gardenoside, rutin, carthamin β-paddy Sterol, rheum emodin, glycyrrhizic acid, kutkin, rubican, alkannin, the one or more among cholic acid are respectively with following one kind Or plurality of raw materials medicine substitutes：1-2 parts of gardenoside, 1-2 parts of rutin are substituted with 25-30 parts of 25-30 parts of cape jasmine or rue；It is red 25-30 parts with safflower of 1-2 parts of florigen substitutes；1-2 parts of cupreol is substituted with 25-30 parts of 25-30 parts of the root of straight ladybell or pseudo-ginseng； 1-2 parts of rheum emodin is substituted with 25-30 parts of 25-30 parts of fringed pink or rheum officinale；25-30 parts with radix glycyrrhizae of 1-2 parts of glycyrrhizic acid substitutes； 25-30 parts with Radix picrorrhizae of 1-2 parts of kutkin substitutes；25-30 parts with madder of 1-2 parts of rubican substitutes；Alkannin 1-2 Part is substituted for 25-30 parts with Asian puccoon；25-30 parts with shellac of 1-2 parts of lac resin substitutes；1-2 parts of cholic acid is with ox courage, sheep 25-30 parts of one or more of courage, pig gall substitute or with arisaema cum bile 25-30 parts substitute.
- 5. according to the anaesthetic of 1 or 2 or 3 or 4 clearing away heat to stop bleeding of claim, it is characterised in that：The bulk drug adds five spirits One or more of 25-30 parts of fat, 25-30 parts of palm ash, 25-30 parts of hairyvein agrimony.
- 6. the anaesthetic of clearing away heat to stop bleeding according to claim 5, it is characterised in that：The anaesthetic includes the raw material of following parts by weight Medicine：25-30 parts of rue, 25-30 parts of safflower, 25-30 parts of pseudo-ginseng, 25-30 parts of rheum officinale, 25-30 parts of radix glycyrrhizae, Radix picrorrhizae 25-30 parts, 25-30 parts of madder, 25-30 parts of Asian puccoon, 25-30 parts of shellac, totally 25-30 parts of the sheep courage of equivalent, pig gall, Blood mores than 25-30 parts, 25-30 parts of calculus bovis factitius, 25-30 parts of excrementum pteropi, 25-30 parts of palm ash, 25-30 parts of hairyvein agrimony.
- 7. the manufacturing process of the anaesthetic of clearing away heat to stop bleeding as claimed in claim 3, it is characterised in that：The processing of the ox horn, deer horn Method is with after the immersion of 75% ethanol or steam disinfection, is ground into fine powder；10 times of weight waters are added to decoct twice, 7~10 is small every time When, the moisture boiled off is supplemented at any time in decoction process；Collecting decoction, filtration, filtrate is concentrated into 1-the 5% of original weight amount, at 80 DEG C After drying below, fine powder is ground into, sieves, produces；Mixed with other bulk drugs, the formulations such as ball, scattered, cream or capsule are made.
- 8. the manufacturing process of the anaesthetic of clearing away heat to stop bleeding as claimed in claim 4, it is characterised in that：The cape jasmine, safflower, pseudo-ginseng or The root of straight ladybell, fringed pink or rheum officinale, radix glycyrrhizae, Radix picrorrhizae, madder, Asian puccoon, shellac, which are beaten powder and crossed more than 80 mesh, to be sieved, after mixing with 70% with On alcohol steep 30-60 minutes, ethanol is recovered under reduced pressure；Extracted 30-60 minutes with ethyl acetate, concentrated after recycling design again To dry grinding, cross more than 60 mesh and sieve, mixed with other bulk drugs, the formulations such as ball, scattered, cream or capsule are made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710988652.4A CN107582899B (en) | 2017-10-21 | 2017-10-21 | Mongolian medicine for clearing heat and stopping bleeding and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710988652.4A CN107582899B (en) | 2017-10-21 | 2017-10-21 | Mongolian medicine for clearing heat and stopping bleeding and its preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107582899A true CN107582899A (en) | 2018-01-16 |
| CN107582899B CN107582899B (en) | 2021-01-15 |
Family
ID=61053517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710988652.4A Active CN107582899B (en) | 2017-10-21 | 2017-10-21 | Mongolian medicine for clearing heat and stopping bleeding and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107582899B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107596247A (en) * | 2017-10-21 | 2018-01-19 | 内蒙古民族大学附属医院 | A kind of anaesthetic and its manufacturing process for treating tuberculosis |
| CN109771414A (en) * | 2019-03-15 | 2019-05-21 | 苏州大学附属第二医院 | A kind of pharmaceutical composition for treating haemorrhagic shock |
| IT202100004898A1 (en) * | 2021-03-02 | 2022-09-02 | S&R Farm S P A | FORMULA FOR TOPICAL USE CHARACTERIZED BY A COMBINATION OF BILE ACIDS AND 5 ALPHA REDUCTASE INHIBITORS FOR THE TREATMENT OF ANDROGEN-DEPENDENT DERMATOSES. |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101703648A (en) * | 2009-10-16 | 2010-05-12 | 西安千禾药业有限责任公司 | Chinese patent medicament for treating hematochezia and preparation method thereof |
-
2017
- 2017-10-21 CN CN201710988652.4A patent/CN107582899B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101703648A (en) * | 2009-10-16 | 2010-05-12 | 西安千禾药业有限责任公司 | Chinese patent medicament for treating hematochezia and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 龚翠琴等: "生血康对特发性血小板减少性紫癜患者骨髓巨核细胞的影响", 《内蒙古民族大学学报(自然科学版)》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107596247A (en) * | 2017-10-21 | 2018-01-19 | 内蒙古民族大学附属医院 | A kind of anaesthetic and its manufacturing process for treating tuberculosis |
| CN107596247B (en) * | 2017-10-21 | 2020-12-22 | 内蒙古民族大学附属医院 | Mongolian medicine for treating lung disease and its preparing process |
| CN109771414A (en) * | 2019-03-15 | 2019-05-21 | 苏州大学附属第二医院 | A kind of pharmaceutical composition for treating haemorrhagic shock |
| CN109771414B (en) * | 2019-03-15 | 2021-04-20 | 苏州大学附属第二医院 | Pharmaceutical composition for treating hemorrhagic shock |
| IT202100004898A1 (en) * | 2021-03-02 | 2022-09-02 | S&R Farm S P A | FORMULA FOR TOPICAL USE CHARACTERIZED BY A COMBINATION OF BILE ACIDS AND 5 ALPHA REDUCTASE INHIBITORS FOR THE TREATMENT OF ANDROGEN-DEPENDENT DERMATOSES. |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107582899B (en) | 2021-01-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104799146A (en) | Functional nutritional good composition for improving sub-health and preparation method thereof | |
| CN103168883A (en) | Pathogenic microorganism preventing antiviral tea beverage granules capable of boosting immunity and preparation method thereof | |
| JP2003192605A (en) | Lipase inhibitant | |
| CN107582899B (en) | Mongolian medicine for clearing heat and stopping bleeding and its preparing process | |
| WO2006063515A1 (en) | Use of radix sanguisorbae and its extract for preparing medicament to increase rbc and hemoglobin | |
| CN108813501A (en) | With the relieving cough and reducing sputum health honey paste relievingd asthma and adjust function of human body of clearing heat and moistening lung | |
| EP1583547B1 (en) | Anti-obesity ingredients from medicinal plants and their composition | |
| CN110652552A (en) | Wound healing formula and preparation method | |
| KR101999675B1 (en) | Herbal composition for the prevention and treatment of coronary heart disease | |
| CN110151851A (en) | Compound and its application based on a kind of Radix Glycyrrhizae medicine pair by honeysuckle | |
| CN105288096B (en) | Medicine for treating whelk | |
| KR101479096B1 (en) | Health functional food comprising extracts of herbal mixture for preventing or improving edema of delivered or pregnant woman | |
| CN104873824A (en) | Traditional Chinese medicine for treating pertussis and preparation method | |
| CN105169149A (en) | Traditional Chinese medicine composition for treating pyrophlegm stasis accumulation type thyroid cancer, preparation method and application | |
| CN105638961A (en) | Dark green tea composition with ramie leaves and preparation method thereof | |
| CN105727156A (en) | Cancer inhibiting and pain relieving cataplasm and preparation method thereof | |
| Algethami et al. | Bee pollen: Clinical trials and patent applications. Nutrients. 2022, 14, 2858 | |
| CN112057535B (en) | Preparation method of traditional Chinese medicine composition for preventing or/and treating dyslipidemia | |
| CN112386654B (en) | Traditional Chinese medicine composition, extract, preparation method and application thereof | |
| CN107596247A (en) | A kind of anaesthetic and its manufacturing process for treating tuberculosis | |
| CN112057536B (en) | Traditional Chinese medicine composition for preventing or/and treating dyslipidemia and application thereof | |
| CN112439016B (en) | Traditional Chinese medicine composition for treating acute soft tissue injury, preparation method and application | |
| Asif | Phytochemical and ethnobotanical effect of Aloe vera | |
| CN105596592A (en) | Postpartum care type traditional Chinese medicine | |
| CN104784666A (en) | Traditional Chinese medicine ointment for orthopedic nursing |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |