CN107531744A - 一种奥贝胆酸的新结晶形式及其制备方法 - Google Patents

一种奥贝胆酸的新结晶形式及其制备方法 Download PDF

Info

Publication number
CN107531744A
CN107531744A CN201780001557.9A CN201780001557A CN107531744A CN 107531744 A CN107531744 A CN 107531744A CN 201780001557 A CN201780001557 A CN 201780001557A CN 107531744 A CN107531744 A CN 107531744A
Authority
CN
China
Prior art keywords
understand
solvent
cholic acid
crystallization
shellfish cholic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201780001557.9A
Other languages
English (en)
Other versions
CN107531744B (zh
Inventor
张顺吉
王生
朱昶臻
田伟伟
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Hengrui Medicine Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co Ltd filed Critical Jiangsu Hengrui Medicine Co Ltd
Publication of CN107531744A publication Critical patent/CN107531744A/zh
Application granted granted Critical
Publication of CN107531744B publication Critical patent/CN107531744B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

本发明涉及一种奥贝胆酸的新结晶形式及其制备方法。具体而言，本发明涉及奥贝胆酸的E型结晶及其制备方法。该晶型十分稳定，且溶剂残留低，适于工业化生产。

Description

PCT国内申请，说明书已公开。

Claims (13)

  1. PCT国内申请，权利要求书已公开。
CN201780001557.9A 2016-03-31 2017-03-30 一种奥贝胆酸的新结晶形式及其制备方法 Active CN107531744B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2016102011300 2016-03-31
CN201610201130 2016-03-31
PCT/CN2017/078821 WO2017167233A1 (zh) 2016-03-31 2017-03-30 一种奥贝胆酸的新结晶形式及其制备方法

Publications (2)

Publication Number Publication Date
CN107531744A true CN107531744A (zh) 2018-01-02
CN107531744B CN107531744B (zh) 2020-03-13

Family

ID=59962610

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780001557.9A Active CN107531744B (zh) 2016-03-31 2017-03-30 一种奥贝胆酸的新结晶形式及其制备方法

Country Status (4)

Country Link
US (1) US11161871B2 (zh)
CN (1) CN107531744B (zh)
TW (1) TWI740922B (zh)
WO (1) WO2017167233A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ31099U1 (cs) * 2017-09-05 2017-10-17 Zentiva, K.S. Krystalické formy (3a,5B,6a,7a)-6-ethyl-3,7- dihydroxycholan-24-ové kyseliny
WO2019197962A1 (en) * 2018-04-09 2019-10-17 Biophore India Pharmaceuticals Pvt. Ltd Crystalline forms of (3α, 5β, 6α, 7α)-6-ethyl-3, 7-dihydroxycholan-24-oic acid (obeticholic acid) and processes thereof
CN112898369A (zh) * 2019-12-04 2021-06-04 博瑞生物医药（苏州）股份有限公司 用于制备奥贝胆酸的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013192097A1 (en) * 2012-06-19 2013-12-27 Intercept Pharmaceuticals, Inc. Preparation, uses and solid forms of obeticholic acid
CN105175473A (zh) * 2015-08-19 2015-12-23 丽珠医药集团股份有限公司 一种奥贝胆酸晶型i及其制备方法、药物组合物和用途
CN105801653A (zh) * 2014-12-30 2016-07-27 苏州晶云药物科技有限公司 奥贝胆酸的晶型a及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1568706A1 (en) * 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Novel steroid agonist for FXR
WO2016045480A1 (zh) 2014-09-28 2016-03-31 上海源力生物技术有限公司 一种奥贝胆酸的制备方法
CN105859814A (zh) * 2015-01-23 2016-08-17 江苏奥赛康药业股份有限公司 一种奥贝胆酸化合物及其药物组合物
CN105985395A (zh) * 2015-02-13 2016-10-05 江苏奥赛康药业股份有限公司 一种奥贝胆酸化合物及含有该化合物的药物组合物
CN105777836A (zh) * 2015-04-09 2016-07-20 厦门蔚扬药业有限公司 奥贝胆酸的多晶型物及其制备方法
CZ2015504A3 (cs) * 2015-07-16 2017-01-25 Zentiva, K.S. Krystalické formy obeticholové kyseliny
CN105085597B (zh) * 2015-08-28 2017-03-29 成都百裕制药股份有限公司 一种无定型奥贝胆酸的制备方法
CN105175476B (zh) * 2015-09-02 2016-12-28 施淑琴 一种从油茶饼粕中提取茶皂素的方法
CN105810653B (zh) 2016-05-03 2018-09-28 扬州国扬电子有限公司 一种设有可共用电极大臂的功率模块

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013192097A1 (en) * 2012-06-19 2013-12-27 Intercept Pharmaceuticals, Inc. Preparation, uses and solid forms of obeticholic acid
CN105801653A (zh) * 2014-12-30 2016-07-27 苏州晶云药物科技有限公司 奥贝胆酸的晶型a及其制备方法
CN105175473A (zh) * 2015-08-19 2015-12-23 丽珠医药集团股份有限公司 一种奥贝胆酸晶型i及其制备方法、药物组合物和用途

Also Published As

Publication number Publication date
TW201736392A (zh) 2017-10-16
CN107531744B (zh) 2020-03-13
WO2017167233A1 (zh) 2017-10-05
US20200299324A1 (en) 2020-09-24
TWI740922B (zh) 2021-10-01
US11161871B2 (en) 2021-11-02

Similar Documents

Publication Publication Date Title
US8258327B2 (en) Crystalline minocycline base and processes for its preparation
EP3248983B1 (en) Crystal form a of obeticholic acid and preparation method therefor
EP3337485B1 (en) Crystalline forms of ibrutinib
EP3272753B1 (en) Preparation method of pci-32765 crystal form a
EP3241837A1 (en) Method for preparing sofosbuvir crystal form-6
CN107531744A (zh) 一种奥贝胆酸的新结晶形式及其制备方法
CN103788062A (zh) 一种比拉斯汀晶型及其制备方法
CZ20022000A3 (cs) Způsoby přípravy a nová krystalická forma leflunomidu
KR970011297B1 (ko) 부스피론 다결정체 및 이를 함유하는 약학적 조성물
EP1789412B1 (en) Crystalline alfuzosin base
EP1673359B1 (en) Process for the preparation of crystalline forms of orlistat
KR970011294B1 (ko) 부스피론의 다형 결정체 형태로의 전환 방법
RU2228931C2 (ru) Кристаллические формы 3-(2,4-дихлорбензил)-2-метил-n-(пентилсульфонил)-3h- бензимидазол-5-карбоксамида
WO2017167949A1 (en) Crystalline forms of bilastine
KR20100028543A (ko) 아로마타제 억제제의 제조 방법
CN103242291A (zh) 一种多晶型高含量苯甲酸阿格列汀的批量生产工艺
EP1858848A1 (en) Process for making crystalline donepezil hydrochloride monohydrate
CN108570045B (zh) 氢溴酸山莨菪碱的晶型、其制备方法、药物组合物
CN105992769A (zh) 一种钠-葡萄糖协同转运蛋白2抑制剂的l-脯氨酸复合物、其一水合物及晶体
EP2197273A1 (en) Process for preparing r-gossypol l-phenylalaninol dienamine
EP2657232A2 (en) Process for the purification of a benzenesulphonamide compound
EP1730153B1 (en) Isopropanol water solvate of olanzapine
EP2072510A1 (en) Crystalline form of azelastine
CN113004202B (zh) 一种高纯度托伐普坦的制备方法
WO2022097017A1 (en) An improved process for the preparation of trigonelline or pharmaceutically acceptable salts thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant