CN107485787A - It is a kind of for four loop constructions of transcranial magnetic stimulation and its application - Google Patents
It is a kind of for four loop constructions of transcranial magnetic stimulation and its application Download PDFInfo
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- CN107485787A CN107485787A CN201710817412.8A CN201710817412A CN107485787A CN 107485787 A CN107485787 A CN 107485787A CN 201710817412 A CN201710817412 A CN 201710817412A CN 107485787 A CN107485787 A CN 107485787A
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- stem cell
- neural stem
- coil
- magnetic stimulation
- transcranial magnetic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
Abstract
The invention discloses a kind of for four loop constructions of transcranial magnetic stimulation and its application, belong to transcranial magnetic stimulation field.The present invention includes four adjacent small coils, two storage capacitors and 12 relays of square structure, and each small coil independently draws positive and negative two leads；The positive outside wire of each storage capacitor connects a controllable silicon as discharge switch respectively；Two storage capacitors control different relays or relay assembly to be powered to different small coils or small coil combination.The Neural stem cell focus at multiple positions of human brain can be stimulated simultaneously using the present invention, meet the Neural stem cell needs of complexity.
Description
Technical field
It is more particularly to a kind of for four loop constructions of transcranial magnetic stimulation and utilization the invention belongs to transcranial magnetic stimulation field
The Neural stem cell focus control method that the structure is realized.
Background technology
Currently, existing transcranial magnetic stimulation is mainly stimulated using Circumferential coils and " 8 "-shaped coil both at home and abroad, annulus
The physiological action region of coil is the ring-band shape region below coil, and the physiological action region of " 8 "-shaped coil is in " 8 " word
The heart, the zone of action at " 8 " word center is generally referred to as " Neural stem cell focus ", so " 8 "-shaped coil has more preferably than Circumferential coils
Focusing.In the clinical research of transcranial magnetic stimulation, finding the physiological activity of human brain by the multiple regions of cerebral cortex jointly
Effect collaboration is completed, therefore in clinical practice, the Neural stem cell of some brain function disease treatments is needed to pierce multiple regions
Swash, needs can not be met by relying solely on " 8 " wordline circle and carrying out stimulation to a brain function region.
Multifocal transcranial magnetic stimulation system can be stimulated, it is necessary to multichannel multiple brain domains simultaneously or alternately
The loop construction and corresponding control software that high voltage power supply, multifocal stimulate are realized jointly.Existing multi-channel magnetic stimulating technology,
Such as the entitled patents (application number 200510015749.4) for leading brain Neural stem cell more, entitled multiple stimulating coils through cranium magnetic
The patent (application number 200810046759.8) of field stimulator, and the entitled multichannel high-voltage pulse electric for transcranial magnetic stimulation
All disclosing its working method in the patent (application number 201510069014.3) of source generator is：N groups high-pressure modular stores up to n
Can electric capacity charging；Master control module controls n group discharge switch modules, n storage capacitor is set to discharge n external stimulating coil.
At present, multifocal cerebral magnetic stimulation coil structure is realized while this area lacks practical, there are following several respects
Reason：First, the transient current in magnetic stimulating coil is very high, peak point current is even up to more than 5000 amperes, takes into account heating and carries
Stream, therefore winding wire section can not be too thin, also should not be too thick, too thick coiling is difficult, and general winding wire is in 6-12 squares of milli
Meter Wei Yi；Second, the pulsed magnetic field of magnetic stimulating coil can will typically reach more than 1.5 teslas, and induction field be able to will reach
More than 60V/m, it is therefore desirable to suitable coil parameter is selected, if the size of coil is too small, it is impossible to reach physiological threshold requirement；
And head surface product is limited, the coil count of arrangement will not be a lot, therefore also should not be too big；3rd, because transient current is very high,
The focus gate control circuit of coil is more complicated.Patent (application number 201220171951.1) proposes that a kind of dynamically changeable is more logical
Road cerebral magnetic stimulation coil array, using straight wire grid as magnetic stimulating coil, such winding inductance quantity is too small, it is difficult to produce
The raw pulsed magnetic field and induction field for meeting physiological threshold stimulus intensity.And patent (application number 200510015749.4) is disclosed
Multilead magnetic stimulator for brain then has 128 stimulating coils, and each coil is diameter 20mm, high 20mm cylindrical coil, line
Circle is wound with 324 circles, this scheme coil dimension is too small, inductance value is too big, the electric current rate of climb by 0.58mm enamel-covered wire coiling
Not enough, sufficiently high pulsed magnetic field and induction field can not be produced；Other wire is too thin, it is difficult to carries big transient current.
The content of the invention
For overcome the deficiencies in the prior art, the present invention proposes a kind of four loop constructions of transcranial magnetic stimulation, can be to people
Realize and either alternatively or simultaneously stimulate in multiple positions of brain.
The present invention provides a kind of four loop constructions for transcranial magnetic stimulation (with reference to figure 1), it is characterised in that four coil knots
Structure is made up of four independent small coils of square structure, and the point of contact region of two adjacent circular coils is burnt for Neural stem cell
Point, each small coil independently draw positive and negative two leads, also two storage capacitors and 12 relays；Each storage capacitor
Positive outside wire connect a controllable silicon respectively as discharge switch；Two storage capacitors control different relay or relay
Combine to different small coils or the power supply of small coil combination.
The small coil of the present invention is that guide line is in hollow cylindrical-shaped structure after coiling some circles.The wherein section of wire
Product scope 6-12 square millimeters.The interior diameter scope of hollow cylindric small coil is 20-40 millimeters；Overall diameter scope is 40-
60 millimeters；Altitude range is 6-12 millimeters.
As shown in Fig. 2 when the small coil of the present invention produces the magnetic field of equidirectional, the lead for flowing into end is defined as A, outflow end
Lead is defined as B, and lead-out wire corresponding to four small coils is respectively 1A/1B, 2A/2B, 3A/3B, 4A/4B.When coil current is from A
End flows into, and when being flowed out from B ends, is defined as coil and leads to forward current；Conversely, being flowed into from B, when A flows out, it is logical reverse to be defined as coil
Electric current.Four loop constructions share 4 Neural stem cell focuses, select a coil to lead to forward current, and another coil leads to reverse current,
Different loops is selected by relay group, produces different Neural stem cell focus effects.The present invention can at least produce seven kinds of magnetic
Focus is stimulated to combine, including four kinds of independent single Neural stem cell focus effects, what two kinds of two Neural stem cell focuses acted on simultaneously, one
Four Neural stem cell focuses of kind act on simultaneously；When two adjacent small coils pass to current in opposite, other two small coils are not
It is powered, each independent single Neural stem cell focus effect；Change different small coil electricity combinations, four kinds of single magnetic can be produced
Focus is stimulated to act on；Four small coils are classified according to up and down or left and right, when the same side passes to positive direction electric current, such as upside
Or left side, opposite side pass to reverse current, such as downside (corresponding to upside) or right side (corresponding to left side), transverse direction can be produced
Or two vertical Neural stem cell focuses act on simultaneously；When four small coils are according to the logical forward direction of two coils on a diagonal
Electric current, another diagonal lead to reverse current, it is possible to achieve four Neural stem cell focuses act on simultaneously.
The present invention, using control relay circuit, determines the connection between small coil according to selected Neural stem cell focus；
Using two storage capacitors to coil power supply；The two storage capacitors are controlled to discharge respectively by two independent silicon controlled modules,
Produce the effect of Neural stem cell focus.According to multiple transcranial magnetic stimulations of the present invention four loop constructions in head, Ke Yikuo
The big position for stimulating Neural stem cell focus, meets more complicated Neural stem cell needs.
Brief description of the drawings
Fig. 1 is that four loop constructions of more Neural stem cell focus transcranial magnetic stimulations and Neural stem cell focus gate control structure block diagram；
Fig. 2 is four coil lead schematic diagrames of more Neural stem cell focus transcranial magnetic stimulations；
Fig. 3 is the schematic diagram of the small loop construction of the present invention, wherein it is the side of small coil that (a), which is the top view (b) of small coil,
View；
Fig. 4 is the schematic diagram of single Neural stem cell focus 1 effect；
Fig. 5 is the schematic diagram of single Neural stem cell focus 2 effect；
Fig. 6 is the schematic diagram of single Neural stem cell focus 3 effect；
Fig. 7 is the schematic diagram of single Neural stem cell focus 4 effect；
Fig. 8 is the schematic diagram that two Neural stem cell focuses act on simultaneously；
Fig. 9 is the schematic diagram that another two Neural stem cell focuses act on simultaneously；
Figure 10 is the schematic diagram that four Neural stem cell focuses act on simultaneously；
Figure 11 is induction field corresponding to four Neural stem cell focuses.
Embodiment
The present invention is further illustrated below in conjunction with the drawings and the specific embodiments.
Fig. 1 is four loop construction structured flowcharts of more Neural stem cell focus transcranial magnetic stimulations, by four of square structure
Independent small coil composition, each small coil independence lead-out wire, also two storage capacitors；The positive pole of each storage capacitor is drawn
Line connects a controllable silicon as discharge switch respectively；Four loop constructions of the invention are made up of four independent small coils, according to flat
Face arranges that 1. four small coils are respectively labeled as, 2., 3., 4..Four small coils are arranged in four quadrants according to rectangular coordinate system
In, 1. small coil is located at first quartile, 2. small coil is located at the second quadrant, 3. small coil is located at third quadrant, small coil 4. position
In fourth quadrant.The structure shares four independent Neural stem cell focuses, and each small coil draws positive and negative two leads, wherein 12
Individual relay is respectively：1B＆2B is 1B ends and the relay at 2B ends of connection coil；1B＆4B is 1B ends and the 4B of connection coil
The relay at end；2A＆C1- is 2A ends and the relay of electric capacity C1 negative terminals of connection coil；4A＆C1- is the 4A ends of connection coil
With the relay of electric capacity C1 negative terminals；2A＆C2+ is 2A ends and the relay of electric capacity C2 anodes of connection coil；3A＆C2+ is connection
The 3A ends of coil and the relay of electric capacity C2 anodes；4A＆C2+ is 4A ends and the relay of electric capacity C2 anodes of connection coil；3B&
2B is 3B ends and the relay at 2B ends of connection coil；3B＆4B is 3B ends and the relay at 4B ends of connection coil；2A＆C2- is
Connect the 2A ends of coil and the relay of electric capacity C2 negative terminals；3A＆C2- is 3A ends and the relay of electric capacity C2 negative terminals of connection coil
Device；4A＆C2- is 4A ends and the relay of electric capacity C2 negative terminals of connection coil.
The course of work of the present invention：Coil power supply is given using two storage capacitors 1 and electric capacity 2.The anode lead-out wire mark of electric capacity 1
C1+ is designated as, negative terminal lead-out wire is labeled as C1-, and the anode lead-out wire of electric capacity 2 is labeled as C2+, and negative terminal lead-out wire is labeled as C2-.According to
Selected Neural stem cell focus, connects different relay assemblies, determines the connection between small coil.Two independent electric discharges are opened
Close, you can control silicon 1 and controllable silicon 2, control the two storage capacitors to discharge respectively.
Fig. 3 is the small loop construction of transcranial magnetic stimulation.Small coil parameter is in the specific embodiment of the invention：Conductor cross-section is joined
Number：4.95mm×1.45mm；The interior diameter of small coil：28mm；The overall diameter of small coil：50mm；The height of small coil：10mm；
Totally 14 circles are in two layers to coil.
Fig. 4 is the generation of single Neural stem cell focus 1, and electric capacity C1 discharges, and 1. coil produces positive magnetic field, 2. coil produces instead
To magnetic field, 3. and 4. no current passes through coil.It can be seen that Neural stem cell focus intersects center positioned at two coils.What electric current flowed through
Path is：C1+ → 1 → 1A of controllable silicon → 1B＆2B → 2A＆C1 → C1-.Contour in Fig. 4 is the coil surface being calculated
Piezomagnetic theory at following 20mm, Neural stem cell focal point induction field value is maximum, is 83.5V/m (volts/meter).Calculating parameter
Select to be that storage capacitor value is 250uF, the rate of change 5.65 × 10 of coil current7A/s (ampere/second), calculates use below
What this parameter was calculated, do not repeating.
Fig. 5 is the generation of single Neural stem cell focus 2, and electric capacity C2 discharges, and 2. coil produces positive magnetic field, 3. coil produces instead
To magnetic field, 1. and 4. no current passes through coil.The path that electric current flows through is：C2+ → 2 → 2A＆C2+ of controllable silicon → 3B＆2B → 3A＆
C2→C2-。
Fig. 6 is the generation of single Neural stem cell focus 3, and electric capacity C2 discharges, and 3. coil produces positive magnetic field, 4. coil produces instead
To magnetic field, 1. and 2. no current passes through coil.The path that electric current flows through is：C2+ → 2 → 3A＆C2+ of controllable silicon → 3B＆4B → 4A＆
C2→C2-。
Fig. 7 is the generation of single Neural stem cell focus 4, and electric capacity C1 discharges, and 1. coil produces positive magnetic field, 4. coil produces instead
To magnetic field, 2. and 3. no current passes through coil.The path that electric current flows through is：C1+ → 1 → 1A of controllable silicon → 1B＆4B → 4A＆C1 →
C1-。
Fig. 8 is produced while being two Neural stem cell focuses, and 1. electric capacity C1 electric discharges, coil produces positive magnetic field, 4. coil produces
Raw opposing magnetic field；Electric capacity C2 discharges, and 2. coil produces positive magnetic field, 3. coil produces opposing magnetic field.It can be seen that highest senses
Four hub of a spools that are distributed in of electric field are distributed along horizontal level.Electric current flows separately through two independent paths：C1+ → controllable silicon
1→1A→1B&4B→4A&C1→C1-；C2+ → 2 → 2A＆C2+ of controllable silicon → 3B＆2B → 3A＆C2 → C2-.Can from contour map
To find out, Neural stem cell focus area induction field is 108V/m, higher than the situation of single Neural stem cell focus.
Fig. 9 is produced while being another two Neural stem cell focuses, 1. electric capacity C1 electric discharges, coil produces positive magnetic field, line
2. circle produces opposing magnetic field；Electric capacity C2 discharges, and 4. coil produces positive magnetic field, 3. coil produces opposing magnetic field.Caused magnetic thorn
It is two vertical positions to swash focus.Electric current flows separately through two independent paths：C1+ → 1 → 1A of controllable silicon → 1B＆2B →
2A&C1→C1-；C2+ → 2 → 4A＆C2+ of controllable silicon → 3B＆4B → 3A＆C2 → C2-.
Figure 10 is produced while being four Neural stem cell focuses, and 1. electric capacity C1 electric discharges, coil produces positive magnetic field, 2. coil produces
Raw opposing magnetic field；Electric capacity C2 discharges, and 3. coil produces positive magnetic field, 4. coil produces opposing magnetic field.Caused Neural stem cell focus
Positioned at coil intersection two-by-two.Electric current flows separately through two independent paths：C1+ → 1 → 1A of controllable silicon → 1B＆2B → 2A＆C1
→C1-；C2+ → 2 → 3A＆C2+ of controllable silicon → 3B＆4B → 4A＆C2 → C2-.From contour map as can be seen that Neural stem cell focal area
Domain induction field is 66.7V/m, less than the situation of single Neural stem cell focus.
Figure 11 is the distribution of induction field corresponding to four Neural stem cell focuses, it can be seen that be coil two-by-two intersection four
Individual peak value.
The present invention can be mounted on the helmet by one or several four loop constructions, it is possible to achieve is produced on head more
Neural stem cell focus, meet the clinical demand of more complicated magnetic stimulation treatment.
Embodiment described above is not intended to limit the present invention, any those skilled in the art, is not departing from this hair
In bright spirit and scope, various change and retouching can be done, therefore protection scope of the present invention regards right institute circle
It is fixed.
Claims (9)
1. a kind of four loop constructions for transcranial magnetic stimulation, it is characterised in that four including square structure adjacent
Small coil, two storage capacitors and 12 relays, each small coil independently draw positive and negative two leads；Each storage capacitor
Positive outside wire connect a controllable silicon respectively as discharge switch；Two storage capacitors control different relay or relay
Combine to different small coils or the power supply of small coil combination.
2. it is used for four loop constructions of transcranial magnetic stimulation described in claim 1, it is characterised in that the small coil is guide line warp
Cross that to coil after some circles be in hollow cylindrical-shaped structure.
3. it is used for four loop constructions of transcranial magnetic stimulation described in claim 2, it is characterised in that the wire cross-section area scope
6-12 square millimeters.
4. it is used for four loop constructions of transcranial magnetic stimulation described in claim 2, it is characterised in that the hollow cylindrical-shaped structure
Interior diameter scope be 20-40 millimeters；Overall diameter scope is 40-60 millimeters；Altitude range is 6-12 millimeters.
5. it is used for four loop constructions of transcranial magnetic stimulation described in claim 1, it is characterised in that the scope of the storage capacitor value
140-300uF。
6. a kind of control method of transcranial magnetic stimulation, it is characterised in that specific steps include：One or more is fixed on head first
Individual four loop construction as claimed in claim 1, the point of contact region between adjacent windings in each four loop construction are magnetic thorn
Swash focus, the position of selection target Neural stem cell focus, determine the connection between small coil；Control two of each four loop construction
Storage capacitor is by relay or relay assembly to selected small coil power supply；Realize that selected target Neural stem cell focus is made
With.
7. the control method of transcranial magnetic stimulation as claimed in claim 6, it is characterised in that respectively to each four loop construction
Two adjacent small coil power supplies, realize four independent single Neural stem cell focus effects of four loop constructions.
8. the control method of transcranial magnetic stimulation as claimed in claim 6, it is characterised in that respectively to each four loop construction
Two groups of adjacent small coil power supplies, realize two Neural stem cell focuses of the different two groups of four loop constructions while act on.
9. the control method of transcranial magnetic stimulation as claimed in claim 6, it is characterised in that respectively to each four loop construction
Small coil power supply, realize four Neural stem cell focuses while act on.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111643817A (en) * | 2020-06-15 | 2020-09-11 | 天津大学 | Triangular net personalized multi-coil transcranial magnetic stimulation array and control method thereof |
| CN112891748A (en) * | 2021-01-21 | 2021-06-04 | 武汉依瑞德医疗设备新技术有限公司 | Magnetic shock therapeutic instrument |
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