CN107466235A - A kind of formula essential oil for the slight frostbite of skin and preparation method thereof - Google Patents
A kind of formula essential oil for the slight frostbite of skin and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/025—Recovery by solvent extraction
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/027—Recovery of volatiles by distillation or stripping
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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Abstract
A kind of formula essential oil for the slight frostbite of skin and preparation method thereof, the formula essential oil is made up of the raw material of following parts by weight：Lavender 57, tea tree ethereal oil 35, eucalyptus quintessence oil 35, Peppermint essential oil 35, black pepper essential oil 35, wheat embryo essential oil 30 40.Preparation method comprises the following steps：Oil yield is determined, determines raw material weight, rough essential oil is obtained by steam distillation, exquisite formula essential oil is obtained by supercritical carbon dioxide extraction method.The formula essential oil can promote cell repair and wound healing.
Description
Technical field
The present invention relates to plants essential oil medicine field, formula essential oil and its preparation side specifically for the slight frostbite of skin
Method.
Background technology
Frostbite is winter relatively conventional wound, and frostbite is generally divided into four degree：I degree of frostbite：Epidermis is injured, it is local red,
It is swollen, itch, pain, heat.II degree of frostbite：Skin corium is injured, it is red, swell, pain, itch more apparent, locally get blister.III degree of frostbite：As deep as skin
Undertissue, early stage is red and swollen and has big bubble, and skin becomes black-and-blue by pale, and consciousness disappears, and tissue is in dry necrosis.IV degree of jelly
Wound：Injure muscle and bone, dryness and moist gangrene occurs, need to make skin graft and amputation.Should for III degree of more serious IV degree of frostbite
Go to see a doctor in time, in order to avoid delay the state of an illness.The present invention carries out grinding for medicine for the slight frostbite of I degree of frostbite and II degree of frostbite
Study carefully and develop.
The content of the invention
In view of this, it is an object of the invention to provide a kind of formula essential oil for the slight frostbite of skin and its preparation side
Method.
To achieve these goals, the technical solution adopted by the present invention is as follows：
A kind of formula essential oil for the slight frostbite of skin, the formula essential oil by weight by 5-7 parts Lavender,
3-5 parts tea tree ethereal oil, 3-5 parts eucalyptus quintessence oil, 3-5 parts Peppermint essential oil, 3-5 part black peppers essential oil, 30-40 parts wheat embryo essence
Oil composition.
Preferably, the formula essential oil is by 5 parts of Lavenders, 3 parts of tea tree ethereal oils, 3 parts of eucalyptus quintessence oils, 3 parts of peppermint essences
Oil, 3 parts of black pepper essential oils, 30 parts of wheat embryo essential oil compositions.
Preferably, the formula essential oil is by 6 parts of Lavenders, 4 parts of tea tree ethereal oils, 4 parts of eucalyptus quintessence oils, 4 parts of peppermint essences
Oil, 4 parts of black pepper essential oils, 35 parts of wheat embryo essential oil compositions.
Preferably, the formula essential oil is by 7 parts of Lavenders, 5 parts of tea tree ethereal oils, 5 parts of eucalyptus quintessence oils, 5 parts of peppermint essences
Oil, 5 parts of black pepper essential oils, 40 parts of wheat embryo essential oil compositions.
The preparation method of the formula essential oil for being used for the slight frostbite of skin described in any of the above-described scheme, comprises the following steps：
(10) by the oil yield of lavender, tea tree, You Jiali, dried peppermint leaf, black pepper and wheat embryo determine lavender,
Parts by weight needed for tea tree, You Jiali, dried peppermint leaf, black pepper and wheat embryo simultaneously weigh standby；
(20) by step (10) obtain needed for the lavenders of parts by weight, tea tree, You Jiali, dried peppermint leaf, black pepper, wheat
Bud is placed in distillation container, 200-250 DEG C of water vapour is passed through wherein, lavender, tea tree, You Jiali, dried peppermint leaf, black pepper
The derived essential oil inside included is diffused into the azeotropic mixture that oil and water are formed in vapor；Then azeotropic mixture is cooled to 25-30 DEG C, obtained
To rough essential oil；
(30) rough essential oil is fitted into extractor, extraction temperature is 45 DEG C, extracting pressure 35MPa, CO2Flow is
In the mixture input separator of 35L/h, 3~5h of continuous extraction, carbon dioxide and the essential oil extracted, reduce to 11MPa and drop
To 35 DEG C, carbon dioxide separates with essential oil, and formula essential oil is made.
Preferably, the oil yield of lavender, tea tree, You Jiali, dried peppermint leaf, black pepper and wheat embryo by walking as follows
It is rapid to determine：
(11) lavender, tea tree, You Jiali, dried peppermint leaf, black pepper or wheat embryo are selected；
(12) lavender, tea tree, You Jiali, dried peppermint leaf, black pepper or wheat embryo that step (11) selects are placed in
Distill in container, 200-250 DEG C of water vapour be passed through to the derived essential oil wherein, included in lavender and is diffused into vapor,
Form the azeotropic mixture of oil and water；Then azeotropic mixture is cooled to 25-30 DEG C, obtains rough essential oil；
(13) the rough essential oil that step (12) obtains is fitted into extractor, extraction temperature is 45 DEG C, and extracting pressure is
35MPa, CO2Flow is 35L/h, 3~5h of continuous extraction, the mixture input separator of carbon dioxide and the essential oil extracted
In, reduce to 11MPa and be down to 35 DEG C, carbon dioxide separates with essential oil, obtains refined essential oil；
(14) by the weight of obtained exquisite essential oil except the weight in raw material obtains lavender, tea tree, You Jiali, peppermint
Leaf, black pepper or the oil yield of wheat embryo；
(15) step 5 time of (11)-(14) is repeated, until all calculating lavender, tea tree, You Jiali, dried peppermint leaf, black Hu
Green pepper and the oil yield of wheat embryo.
Preferably, lavender, tea tree, You Jiali, dried peppermint leaf, black pepper and the wheat embryo that step (15) is determined
Oil yield corresponds to respectively in order：0.9%, 1.8%, 0.8%, 1.0%, 2.5%, 7.5%.
Due to the influence of the extraction yield of supercritical carbon dioxide extracting aromatic vegetable oil, including extraction temperature, extracting pressure
And CO2Flow, therefore inventor has paid performing creative labour, draw lavender, tea tree, You Jiali, dried peppermint leaf, black pepper with
And the optimal married operation condition of wheat embryo is：Extraction temperature is 45 DEG C, extracting pressure 35MPa, CO2Flow is 35L/h.
And according to the optimal married operation condition, in the case where identical operation is submitted, lavender, tea tree, You Jiali, peppermint are determined respectively
Leaf, black pepper and the oil yield of wheat embryo.
The beneficial effects of the present invention are：
In the preparation method of the present invention, raw material institute expense is determined by oil yield, without being fractionated to essential oil
Mixed again afterwards, enormously simplify preparation process.
Prepared by the present invention, which is used for the formula essential oil that the slight frostbite of skin is hindered, is formed by pure plant extraction component, energy
Frostbite skin part cell repair is effectively facilitated to cicatrize a wound.
Formula essential oil prepared by the present invention is used to treat slight frostbite, is formulated the various pieces in essential oil to frostbite skin all
There is the effect of different.Lavender has the ability of anti-inflammation, moreover it is possible to promotes cell tissue regrowth.Tea tree ethereal oil has
There is good sterilizing to act on, can be the good anti-inflammatory of wound, there is obvious effect to skin frostbite, using equal after tea tree ethereal oil
Reaction is good.Eucalyptus quintessence oil has obvious effect to skin frostbite, and prevention cell grows and stored purulence, promotes neoblastic construction.
Peppermint essential oil energy contract skin capilary, stimulates circulation, and promotes toxin discharge.Black pepper essential oil has purification, improves wound
The suppuration phenomenon of infection.Wheat embryo essential oil antioxidation, promotes skin moisture-keeping to make as the base oil in the formula essential oil
With making skin moisten, promote skin metabolism and skin renewal.
The present invention select 5 kinds of different essential oils and a kind of base oil compositing formula essential oil, each composition coordination in the formula essential oil
Effect has stronger bactericidal action, and sterilizing rate prevents trauma surface infestation, while the invention product can also control frostbite up to 100%
Wound tissue liquid oozes out；Essential oil seepage velocity is very fast, can improve surface of a wound blood circulation, quick anti-inflammatory analgetic, accelerate the surface of a wound to be cured
Conjunction and preventing from scar, so as to which the formula essential oil of the present invention can be used for the treatment slight frostbite of skin.
Embodiment
Below by specific embodiment, the present invention is described in detail, but the purposes of these exemplary embodiments and
Purpose is only used for enumerating the present invention, not forms any type of any restriction to the real protection scope of the present invention, more non-to incite somebody to action
Protection scope of the present invention is confined to this.
Inventor is to have passed through multiple composition adjustment to test with dosage, pays creative work and just obtains the present invention.Under
What face to be enumerated is only some preferable research experiments, included in the experiment some concrete components for having adjusted and
Concrete content, the embodiment of this limited number of time is simultaneously exhaustive, and those skilled in the art can adjust other components and ratio accordingly, and it is imitated
Fruit is expectable, then all should be in the range of disclosure of the invention.
In addition, unless stated otherwise, below number used in component be parts by weight.
Embodiment 1：
A kind of preparation method of formula essential oil for the slight frostbite of skin, comprises the following steps：
1) weigh 556 portions of lavenders, 167 portions of tea trees, 375 parts of You Jiali, 300 parts of dried peppermint leaves, 120 parts of black peppers, 400 parts
Wheat embryo is placed in distillation container, 200-250 DEG C of water vapour is passed through wherein, lavender, tea tree, You Jiali, dried peppermint leaf,
The derived essential oil included in black pepper is diffused into the azeotropic mixture that oil and water are formed in vapor；Then azeotropic mixture is cooled to 25-
30 DEG C, obtain rough essential oil；
2) rough essential oil is fitted into extractor, extraction temperature is 45 DEG C, extracting pressure 35MPa, CO2Flow is 35L/
In the mixture input separator of h, 3~5h of continuous extraction, carbon dioxide and the essential oil that extracts, reduce to 11MPa and be down to 35
DEG C, carbon dioxide separates with essential oil, and formula essential oil is made.
Embodiment 2
A kind of preparation method of formula essential oil for the slight frostbite of skin, comprises the following steps：
1) weigh 667 portions of lavenders, 222 portions of tea trees, 500 parts of You Jiali, 400 parts of dried peppermint leaves, 160 parts of black peppers, 467 parts
Wheat embryo is placed in distillation container, 200-250 DEG C of water vapour is passed through wherein, lavender, tea tree, You Jiali, dried peppermint leaf,
The derived essential oil included in black pepper is diffused into the azeotropic mixture that oil and water are formed in vapor；Then azeotropic mixture is cooled to 25-
30 DEG C, obtain rough essential oil；
2) rough essential oil is fitted into extractor, extraction temperature is 45 DEG C, extracting pressure 35MPa, CO2Flow is 35L/
In the mixture input separator of h, 3~5h of continuous extraction, carbon dioxide and the essential oil that extracts, reduce to 11MPa and be down to 35
DEG C, carbon dioxide separates with essential oil, and formula essential oil is made.
Embodiment 3
A kind of preparation method of formula essential oil for the slight frostbite of skin, comprises the following steps：
1) weigh 778 portions of lavenders, 278 portions of tea trees, 625 parts of You Jiali, 500 parts of dried peppermint leaves, 200 parts of black peppers, 533 parts
Wheat embryo is placed in distillation container, 200-250 DEG C of water vapour is passed through wherein, lavender, tea tree, You Jiali, dried peppermint leaf,
The derived essential oil included in black pepper is diffused into the azeotropic mixture that oil and water are formed in vapor；Then azeotropic mixture is cooled to 25-
30 DEG C, obtain rough essential oil；
2) rough essential oil is fitted into extractor, extraction temperature is 45 DEG C, extracting pressure 35MPa, CO2Flow is 35L/
In the mixture input separator of h, 3~5h of continuous extraction, carbon dioxide and the essential oil that extracts, reduce to 11MPa and be down to 35
DEG C, carbon dioxide separates with essential oil, and formula essential oil is made.
The obtained formula essential oil of embodiment 1- embodiments 3 is subjected to bactericidal effect detection, the strain of test is Escherichia coli,
Gold-coloured staphylococci and Candida albicans.Method of testing presses GB15979-2002《Disposable health product sanitary standard》Annex
C3 items " bactericidal property test method " are carried out, and the result of test is as shown in table 1.
Table 1
As it can be seen from table 1 the bactericidal effect of the formula essential oil for being used for the slight frostbite of skin prepared by embodiment is very good,
After effect 2 minutes, sterilizing rate, and can be with long-acting bacteriostatic up to 100%.
Formula essential oil for the slight frostbite of skin prepared by the present embodiment 1-3 is tested for frostbite patient, is made
It is with method：3-5 drops are dripped to affected part immediately after frostbite warm water washing, are used 3-5 times daily.To 30 trouble using this product
Person makes investigation, and as a result see the table below 2.
Table 2
From table 2 it can be seen that the present embodiment 1-3 formula essential oil for the slight frostbite of skin is for slight frostbite patient
Effectively, there is not the situation of wound infection, the recovery and cytothesis to skin create good condition.It is various into
Under the synergy divided, cure rate 100%.
It should be strongly noted that the formula essential oil of the present invention is by weight by 5-7 parts Lavender, 3-5 part tea
Set essential oil, 3-5 parts eucalyptus quintessence oil, 3-5 parts Peppermint essential oil, 3-5 part black peppers essential oil, 30-40 part wheat embryos essential oil composition.
Its content number includes the number for falling into the application content range that can be obtained by way of rounding up in error range.
In error range within 2%, its content value, which is considered as, to be equal, such as 5 parts of Lavender, can be equal to Lavender
4.9 parts or 4.99 parts of Lavender etc., 7 parts of Lavender, 7.1 parts of Lavender, or lavender can be equal to
7.01 parts of essential oil.These above-mentioned numbers are belonged in the content range of the application.
It should be appreciated that after the technology contents of the present invention have been read, those skilled in the art can make each to the present invention
Kind change, modification and/or variation, all these equivalents are equally fallen within protection scope of the present invention.
Claims (7)
1. a kind of formula essential oil for the slight frostbite of skin, it is characterised in that the formula essential oil is smoked by 5-7 parts by weight
Clothing grass essential oil, 3-5 parts tea tree ethereal oil, 3-5 parts eucalyptus quintessence oil, 3-5 parts Peppermint essential oil, 3-5 part black peppers essential oil, 30-40 parts
Wheat embryo essential oil forms.
2. the formula essential oil according to claim 1 for the slight frostbite of skin, it is characterised in that the formula essential oil is by 5
Part Lavender, 3 parts of tea tree ethereal oils, 3 parts of eucalyptus quintessence oils, 3 parts of Peppermint essential oils, 3 parts of black pepper essential oils, 30 parts of wheat embryos
Essential oil forms.
3. the formula essential oil according to claim 1 for the slight frostbite of skin, it is characterised in that the formula essential oil is by 6
Part Lavender, 4 parts of tea tree ethereal oils, 4 parts of eucalyptus quintessence oils, 4 parts of Peppermint essential oils, 4 parts of black pepper essential oils, 35 parts of wheat embryos
Essential oil forms.
4. the formula essential oil according to claim 1 for the slight frostbite of skin, it is characterised in that the formula essential oil is by 7
Part Lavender, 5 parts of tea tree ethereal oils, 5 parts of eucalyptus quintessence oils, 5 parts of Peppermint essential oils, 5 parts of black pepper essential oils, 40 parts of wheat embryos
Essential oil forms.
5. the preparation method of any described formula essential oils for being used for the slight frostbite of skin of claim 1-4, it is characterised in that bag
Include following steps：
(10) lavender, tea are determined by the oil yield of lavender, tea tree, You Jiali, dried peppermint leaf, black pepper and wheat embryo
Parts by weight needed for tree, You Jiali, dried peppermint leaf, black pepper and wheat embryo simultaneously weigh standby；
(20) lavender, tea tree, You Jiali, dried peppermint leaf, black pepper, the wheat embryo that step (10) is obtained to required parts by weight are put
In in distillation container, 200-250 DEG C of water vapour is passed through wherein, lavender, tea tree, You Jiali, wrapped in dried peppermint leaf, black pepper
The derived essential oil contained is diffused into the azeotropic mixture that oil and water are formed in vapor；Then azeotropic mixture is cooled to 25-30 DEG C, obtained thick
Essential oil processed；
(30) rough essential oil is fitted into extractor, extraction temperature is 45 DEG C, extracting pressure 35MPa, CO2Flow is 35L/h,
In the mixture input separator of 3~5h of continuous extraction, carbon dioxide and the essential oil that extracts, reduce to 11MPa and be down to 35 DEG C,
Carbon dioxide separates with essential oil, and formula essential oil is made.
6. the preparation method of formula essential oil according to claim 5, it is characterised in that lavender, tea tree, You Jiali, thin
Lotus leaf, black pepper and the oil yield of wheat embryo determine as follows：
(11) lavender, tea tree, You Jiali, dried peppermint leaf, black pepper or wheat embryo are selected；
(12) lavender, tea tree, You Jiali, dried peppermint leaf, black pepper or wheat embryo that step (11) selects are placed in distillation
In container, 200-250 DEG C of water vapour is passed through to the derived essential oil wherein, included in lavender and is diffused into vapor, formed
The azeotropic mixture of oil and water；Then azeotropic mixture is cooled to 25-30 DEG C, obtains rough essential oil；
(13) the rough essential oil that step (12) obtains being fitted into extractor, extraction temperature is 45 DEG C, extracting pressure 35MPa,
CO2 flows are 35L/h, 3~5h of continuous extraction, in the mixture input separator of carbon dioxide and the essential oil extracted, are reduced to
11MPa is simultaneously down to 35 DEG C, and carbon dioxide separates with essential oil, obtains refined essential oil；
(14) weight that the weight of obtained exquisite essential oil is removed in raw material is obtained into lavender, tea tree, You Jiali, dried peppermint leaf, black
Pepper or the oil yield of wheat embryo；
(15) repeat (11)-(14) step 5 time, until all calculate lavender, tea tree, You Jiali, dried peppermint leaf, black pepper with
And the oil yield of wheat embryo.
7. the preparation method of formula essential oil according to claim 6, it is characterised in that what step (15) was determined smokes clothing
Grass, tea tree, You Jiali, dried peppermint leaf, black pepper and the oil yield of wheat embryo correspond to respectively in order：0.9%, 1.8%,
0.8%, 1.0%, 2.5%, 7.5%.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2016/080301 WO2017185246A1 (en) | 2016-04-27 | 2016-04-27 | Compound essential oil for treating mild skin frostbite, and preparation method therefor |
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| Publication Number | Publication Date |
|---|---|
| CN107466235A true CN107466235A (en) | 2017-12-12 |
| CN107466235B CN107466235B (en) | 2020-12-04 |
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| CN201680011560.4A Active CN107466235B (en) | 2016-04-27 | 2016-04-27 | Formula essential oil for mild skin frostbite and preparation method thereof |
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| WO (1) | WO2017185246A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112450229A (en) * | 2020-12-09 | 2021-03-09 | 华南农业大学 | Plant essential oil type ultraviolet sterilization synergist and ultraviolet combined sterilization method thereof |
| WO2022121420A1 (en) * | 2020-12-09 | 2022-06-16 | 华南农业大学 | Ultraviolet sterilization synergist and sterilization method using same in combination with ultraviolet |
Citations (2)
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| CN101843652A (en) * | 2009-03-24 | 2010-09-29 | 常昊 | Moleplant seed composite essential oil |
| CN102836351A (en) * | 2012-09-03 | 2012-12-26 | 皖南医学院 | Skin care essential balm for relieving itching and diminishing swelling and preparation method thereof |
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| CN101843652A (en) * | 2009-03-24 | 2010-09-29 | 常昊 | Moleplant seed composite essential oil |
| CN102836351A (en) * | 2012-09-03 | 2012-12-26 | 皖南医学院 | Skin care essential balm for relieving itching and diminishing swelling and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112450229A (en) * | 2020-12-09 | 2021-03-09 | 华南农业大学 | Plant essential oil type ultraviolet sterilization synergist and ultraviolet combined sterilization method thereof |
| WO2022121420A1 (en) * | 2020-12-09 | 2022-06-16 | 华南农业大学 | Ultraviolet sterilization synergist and sterilization method using same in combination with ultraviolet |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017185246A1 (en) | 2017-11-02 |
| CN107466235B (en) | 2020-12-04 |
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