CN107441580B - 包括抗微生物表面涂层的医疗装置以及用于控制此装置的表面上的微生物的方法 - Google Patents
包括抗微生物表面涂层的医疗装置以及用于控制此装置的表面上的微生物的方法 Download PDFInfo
- Publication number
- CN107441580B CN107441580B CN201710304144.XA CN201710304144A CN107441580B CN 107441580 B CN107441580 B CN 107441580B CN 201710304144 A CN201710304144 A CN 201710304144A CN 107441580 B CN107441580 B CN 107441580B
- Authority
- CN
- China
- Prior art keywords
- powder coating
- medical device
- antimicrobial
- additive
- ions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000011248 coating agent Substances 0.000 title claims abstract description 40
- 238000000576 coating method Methods 0.000 title claims abstract description 40
- 230000000845 anti-microbial effect Effects 0.000 title claims abstract description 39
- 244000005700 microbiome Species 0.000 title claims abstract description 20
- 239000004599 antimicrobial Substances 0.000 title claims abstract description 12
- 238000000034 method Methods 0.000 title claims abstract description 10
- 239000000843 powder Substances 0.000 claims abstract description 29
- 239000000654 additive Substances 0.000 claims abstract description 24
- 239000008280 blood Substances 0.000 claims abstract description 23
- 210000004369 blood Anatomy 0.000 claims abstract description 23
- 230000000996 additive effect Effects 0.000 claims description 17
- 150000002500 ions Chemical class 0.000 claims description 11
- 239000012876 carrier material Substances 0.000 claims description 10
- 229910052751 metal Inorganic materials 0.000 claims description 10
- 239000002184 metal Substances 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 9
- 230000001699 photocatalysis Effects 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 4
- 230000003641 microbiacidal effect Effects 0.000 claims description 4
- 125000002524 organometallic group Chemical group 0.000 claims description 4
- 230000002503 metabolic effect Effects 0.000 claims description 2
- 239000011941 photocatalyst Substances 0.000 claims description 2
- 230000002459 sustained effect Effects 0.000 claims 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 12
- 239000000463 material Substances 0.000 description 11
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 10
- 239000000084 colloidal system Substances 0.000 description 8
- 239000004033 plastic Substances 0.000 description 8
- 229920003023 plastic Polymers 0.000 description 8
- 230000002572 peristaltic effect Effects 0.000 description 6
- 230000007774 longterm Effects 0.000 description 5
- 239000002105 nanoparticle Substances 0.000 description 5
- 229910052709 silver Inorganic materials 0.000 description 5
- 239000004332 silver Substances 0.000 description 5
- 239000004408 titanium dioxide Substances 0.000 description 5
- 230000009471 action Effects 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 238000010348 incorporation Methods 0.000 description 4
- 241000700605 Viruses Species 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- SJIXRGNQPBQWMK-UHFFFAOYSA-N 2-(diethylamino)ethyl 2-methylprop-2-enoate Chemical compound CCN(CC)CCOC(=O)C(C)=C SJIXRGNQPBQWMK-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000004872 arterial blood pressure Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- 229940124561 microbicide Drugs 0.000 description 2
- 239000002855 microbicide agent Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- -1 silver ions Chemical class 0.000 description 2
- RRHXZLALVWBDKH-UHFFFAOYSA-M trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium;chloride Chemical compound [Cl-].CC(=C)C(=O)OCC[N+](C)(C)C RRHXZLALVWBDKH-UHFFFAOYSA-M 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- QLAJNZSPVITUCQ-UHFFFAOYSA-N 1,3,2-dioxathietane 2,2-dioxide Chemical compound O=S1(=O)OCO1 QLAJNZSPVITUCQ-UHFFFAOYSA-N 0.000 description 1
- QHVBLSNVXDSMEB-UHFFFAOYSA-N 2-(diethylamino)ethyl prop-2-enoate Chemical compound CCN(CC)CCOC(=O)C=C QHVBLSNVXDSMEB-UHFFFAOYSA-N 0.000 description 1
- DPBJAVGHACCNRL-UHFFFAOYSA-N 2-(dimethylamino)ethyl prop-2-enoate Chemical compound CN(C)CCOC(=O)C=C DPBJAVGHACCNRL-UHFFFAOYSA-N 0.000 description 1
- BEWCNXNIQCLWHP-UHFFFAOYSA-N 2-(tert-butylamino)ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCNC(C)(C)C BEWCNXNIQCLWHP-UHFFFAOYSA-N 0.000 description 1
- KDAKDBASXBEFFK-UHFFFAOYSA-N 2-(tert-butylamino)ethyl prop-2-enoate Chemical compound CC(C)(C)NCCOC(=O)C=C KDAKDBASXBEFFK-UHFFFAOYSA-N 0.000 description 1
- XHZPRMZZQOIPDS-UHFFFAOYSA-N 2-Methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid Chemical compound OS(=O)(=O)CC(C)(C)NC(=O)C=C XHZPRMZZQOIPDS-UHFFFAOYSA-N 0.000 description 1
- PLWQJHWLGRXAMP-UHFFFAOYSA-N 2-ethenoxy-n,n-diethylethanamine Chemical compound CCN(CC)CCOC=C PLWQJHWLGRXAMP-UHFFFAOYSA-N 0.000 description 1
- UFQHFMGRRVQFNA-UHFFFAOYSA-N 3-(dimethylamino)propyl prop-2-enoate Chemical compound CN(C)CCCOC(=O)C=C UFQHFMGRRVQFNA-UHFFFAOYSA-N 0.000 description 1
- JPVNTYZOJCDQBK-UHFFFAOYSA-N 3-ethenoxypropan-1-amine Chemical compound NCCCOC=C JPVNTYZOJCDQBK-UHFFFAOYSA-N 0.000 description 1
- FLCAEMBIQVZWIF-UHFFFAOYSA-N 6-(dimethylamino)-2-methylhex-2-enamide Chemical compound CN(C)CCCC=C(C)C(N)=O FLCAEMBIQVZWIF-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 238000004873 anchoring Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000000385 dialysis solution Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 125000005647 linker group Chemical group 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- VNLHOYZHPQDOMS-UHFFFAOYSA-N n-[3-(diethylamino)propyl]-2-methylprop-2-enamide Chemical compound CCN(CC)CCCNC(=O)C(C)=C VNLHOYZHPQDOMS-UHFFFAOYSA-N 0.000 description 1
- ADTJPOBHAXXXFS-UHFFFAOYSA-N n-[3-(dimethylamino)propyl]prop-2-enamide Chemical compound CN(C)CCCNC(=O)C=C ADTJPOBHAXXXFS-UHFFFAOYSA-N 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- USFMMZYROHDWPJ-UHFFFAOYSA-N trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium Chemical compound CC(=C)C(=O)OCC[N+](C)(C)C USFMMZYROHDWPJ-UHFFFAOYSA-N 0.000 description 1
- UZNHKBFIBYXPDV-UHFFFAOYSA-N trimethyl-[3-(2-methylprop-2-enoylamino)propyl]azanium;chloride Chemical compound [Cl-].CC(=C)C(=O)NCCC[N+](C)(C)C UZNHKBFIBYXPDV-UHFFFAOYSA-N 0.000 description 1
- FKMJROWWQOJRJX-UHFFFAOYSA-M triphenyl(prop-2-enyl)phosphanium;chloride Chemical compound [Cl-].C=1C=CC=CC=1[P+](C=1C=CC=CC=1)(CC=C)C1=CC=CC=C1 FKMJROWWQOJRJX-UHFFFAOYSA-M 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B1/00—Layered products having a non-planar shape
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/1645—Constructional aspects thereof with mechanically linked peristaltic dialysis fluid pumps one upstream, the other one downstream of the dialyser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
- A61M1/1656—Apparatus for preparing dialysates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B1/00—Layered products having a non-planar shape
- B32B1/08—Tubular products
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/18—Layered products comprising a layer of synthetic resin characterised by the use of special additives
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
- C09D5/03—Powdery paints
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
- C09D5/03—Powdery paints
- C09D5/033—Powdery paints characterised by the additives
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
- C09D5/08—Anti-corrosive paints
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
- C09D5/14—Paints containing biocides, e.g. fungicides, insecticides or pesticides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/087—Particle radiation, e.g. electron-beam, alpha or beta radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/088—Radiation using a photocatalyst or photosensitiser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/23—Solid substances, e.g. granules, powders, blocks, tablets
- A61L2/232—Solid substances, e.g. granules, powders, blocks, tablets layered or coated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/24—Medical instruments, e.g. endoscopes, catheters, sharps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0056—Catheters; Hollow probes characterised by structural features provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0238—General characteristics of the apparatus characterised by a particular materials the material being a coating or protective layer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Wood Science & Technology (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Materials Engineering (AREA)
- Public Health (AREA)
- Vascular Medicine (AREA)
- Plant Pathology (AREA)
- Emergency Medicine (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Mechanical Engineering (AREA)
- Inorganic Chemistry (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- External Artificial Organs (AREA)
- Materials For Medical Uses (AREA)
Abstract
本发明涉及一种用于体外血液处理的医疗装置,其包括抗微生物表面涂层,其特征在于所述抗微生物表面涂层是粉末涂层。还涉及用于控制医疗装置的表面上的微生物(microbe)与微生物(microorganism)的方法,其中粉末涂层包含具有抗微生物作用的组分,尤其是添加剂。
Description
技术领域
本发明涉及医疗装置(apparatus),尤其是用于体外血液处理的医疗装置,其包括抗微生物表面涂层,以及用于控制本发明的医疗装置的表面上的微生物的方法。
背景技术
在医疗装置的表面上的微生物的生长与增殖是不期望的作用,代表了在诸如医院、实验室、医疗团体等相应治疗环境中的很大的卫生风险并且损害了此医疗装置与物体的实践价值。一般来说,通过相应的清洗与消毒在此环境中微生物被击退。
然而,期望的是微生物一点也不扩散和沉降,或者仅以大大延迟的方式扩散和沉降。此目的还在WO2011/130124A1中实行,其公开了用于使抗微生物剂和染料固定在医疗装置的塑料表面上的方法。这里,通过具有连接基团的多个功能基团来处理塑料壳体,并且在塑料壳体上有抗微生物剂聚集。可能发生塑料的某些特性方面的不利影响,诸如抗老化、抗张强度、抗冲击性等被在塑料基质中引入添加剂不利地影响。
DE102005042181A1在这一点上公开了模制本体,其尤其用于医疗装置和/或医疗产品的装置部件、装置上壳体、装置内部部件、装置配件、装置组件、印模材料、填充材料,其至少分段形成以便抗病菌(germ)定植。此外,公开了包括至少一个此类模制本体的医疗装置以及制造此模制本体的方法。这里,一种途径是将此表面设计为使得通过减少附着来抵抗病菌。另一种途径是在塑料中引入抗微生物剂(biocide)。
发明内容
从上述现有技术开始,本发明以消除上述弊端的目的为基础,尤其提供了具有抗微生物特性并且可以以简单方式制造的医疗装置。理想的是壳体材料的机械特性不被抗微生物特性不利地影响。
根据本发明,通过初始提及的类型的医疗装置实现了此目的,其特征在于抗微生物表面涂层是粉末涂层。根据此处理,通过控制医疗装置(尤其是根据本发明的医疗装置)的表面上的微生物(microbe)与微生物(microorganism)的方法实现了此目的,其中粉末涂层包含具有抗微生物作用的组分,尤其是添加剂。此抗微生物粉末涂层以特别简单且有效的方式防止了微生物,尤其是细菌与真菌培养的发生与发展。
根据本发明,粉末涂层可以涂覆在医疗装置的装置壳体上,其预期用途尤其是在体外血液处理领域中。在本发明的上下文中,术语“微生物”还可以理解为包括病毒。抗微生物表面的作用基于包括在涂层中的组分(添加剂),这在对抗微生物上是高度有效而且对于人来说是无害的。
由于其是以涂覆在基部材料上的粉末涂层的形式的涂层,因此与其功能性相关的壳体的特性将不改变。在这一点上,这些包括例如壳体材料的机械特性或者构成壳体的部件的EMC特性(电磁兼容性)。这进一步不同于例如通过塑料中的集成纳米颗粒产生的抗微生物表面。通过此原理,还会损坏形成壳体的基部材料的特性。
在从属权利要求中要求保护了本发明的有利实施方案,并且将在下面更加详细地说明它们。
粉末涂层可以仅涂覆在装置的部分中或部分上或者在全部表面区域上。通过实例的方式,可能仅存在于通过患者或操作员工触摸的那些区域,诸如外部区域或操作单元。然而,如果粉末涂层涂覆并且形成在整个表面区域上,其也在本发明的范围内。
本发明的一个实施方案的特征在于此粉末涂层涂覆在金属表面上。作为替代或补充,医疗装置可以包括装置壳体并且粉末涂层可以至少部分地涂覆在装置壳体上。特别有利的是,本发明可以与金属壳体或壳体部件一起使用,例如在材料的基质中引入微生物学活性物质,因为其对于塑料是通常做法,在本文中是不可能的,或者会带来基础材料的伴随弱化。
根据本发明的另一个实施方案,粉末涂层包括作为离子和/或自由基的发射体(emitter)的组分,尤其是添加剂。这允许以恒定量,优选地永久地,尤其以持续方式形成新的离子和/或自由基,并且从粉末涂层发射这些离子和/或自由基。发射的离子和/或自由基攻击微生物或细胞的新陈代谢***,使得这些微生物或细胞死去。抗微生物粉末涂层防止它们以此种方式增殖。由于离子和/或自由基的永久形成,与诸如纯的/未结合的纳米银的使用的其它原理相比,关于长期作用的显著性差异可以进行量化。
包含在此粉末涂层中的组分或添加剂可以尤其是具有电离作用的有机金属物质。通过实例,这些添加剂是具有电离和/或光催化效应的有机金属物质。
在此方面,将要提及还称作为辅助剂或外加剂的添加剂,即以少量添加到产品以便达到或改进某些特性的物质。这里,此添加剂具有将有抗微生物作用的物质永久地锚定在载体材料的结构中以实现长期作用的任务。具有抗微生物作用的物质例如是,由银制成的金属胶体、由铜制成的金属胶体、二氧化钛、作为抗微生物剂添加剂的氧化锌等,或者也可以是抗微生物低聚物。
粉末涂层可以尤其包括离子发射体和/或催化剂附着到那里的载体物质。术语“附着”在此意义上应该理解为连接,化学连接等。
特别有利的是此粉末涂层允许例如通过特定结构或颜色设计产生表面处理(asurface finish),然而与此同时施加所述的抗微生物作用。更重要的是,除了期望的抗微生物作用以外,粉末涂层允许实现诸如防腐蚀等的其它作用。
附图文字
下面将根据在附图中示出的示例性、非限定实施方式更加详细地说明本发明,在附图中:
图1示出了作为根据本发明的用于医疗装置的实例的用于体外血液处理的设备(device)的一部分的示意图;
图2示出了纳米银的功效对时间的图解;
图3示出了本发明的抗微生物添加剂的功效对时间的图解;
图4示出了光催化过程的图解;以及
图5A和图5B示出了将纯的/未结合的纳米粒子并入载体材料的栅格结构(a gridstructure)中的图解以及将结合抗微生物活性剂的添加剂并入载体材料的栅格结构中抗微生物的图解。
具体实施方式
基本上示出了设备的整个体外血液循环***。所述循环***包括将血液从患者(未示出)传送到治疗设备的蠕动泵2的动脉血液导管1。在蠕动泵2的上游,设有动脉压传感器3,其测量蠕动泵2上游的压力,即低压侧压力。在蠕动泵2的高压侧,高压血液导管4延伸到动脉血液收集器5。直接地在蠕动泵2的出口处,供给线6与泵7允许将例如肝素的添加剂添加到***中的血液以使血液稀释。
从动脉血液收集器5开始,导管8将仍未处理且加载有渣物质的高压血液传送到透析器9。所述透析器使其输入侧经由透析液供给线10供给以透析液。在透析器9中,血液以已知方式通过透析液处理,例如被清洗。用过的透析液被经由透析液排放线11从透析器9排放并且传送到(未示出的)处置或制备。经处理的血液通过血液排放线12从透析器9传送到其中空气通过防气阀14分离的静脉空气收集器13。在静脉空气收集器13上设有探测静脉压力,即高压侧压力的静脉压传感器15。从防气阀14开始,经处理的血液经由静脉血液导管16返回患者。图1还示出了用于监控与控制此设备的单元17。用于体外血液处理的设备封装在壳体100中,所述壳体至少部分地实施为模制钣金件。
根据本发明,至少壳体100设有粉末涂层。所述涂层可以仅涂覆在部分中或者在全部表面区域上。粉末涂层可以另外地设置并且涂覆在此设备的其它单元上,诸如例如在控制单元17上。
图2以图表示出了纳米银的抗微生物功效。图3以类似图表示出了根据本发明的抗微生物功效。这里,横坐标示出了时间的长度并且纵坐标示出各情形中的功效。应该看到的是纳米银的最大功效是每小时大约103个病菌,本发明的功效是每小时大约5*103个病菌。在短的时间以后纳米银的功效首先以缓慢方式下降,但是然后越来越快并且最后在大约四周以后达到停止。在另一个方面,根据本发明的功效持续长的时间段并且不减小。
纳米银的抗微生物作用以在银纳米颗粒或银胶体的表面上形成银离子(Ag+)为基础。基于银胶体的尺寸与表面面积之间的特定比率可以实现卓越的长期作用。产生的银离子以多种方式对诸如细菌、酵母菌、真菌和病毒的单细胞生物体具有有害作用。纳米银的强抗微生物功效与其穿过细胞壁与细胞膜的能力相关并且在细胞内部中起作用。在体外,胶体银对抗病毒也是有效的,在于纳米银颗粒结合到它们的表面并且抑制病毒结合到宿主细胞。其它抗微生物金属胶体例如是铜胶体。
例如由二氧化钛制成的纳米颗粒的抗微生物作用以与光辐射相结合的光催化处理为基础,这致使稳定反应。在此处理中,基于稳定的光化学激发,例如通过日光,二氧化钛用作光催化剂。这导致物理与化学反应(还原、氧化)(参见图4)。在二氧化钛的情形中,将会产生羟基自由基、超氧阴离子自由基和过氧化氢。自由基能够与有机物质反应并且氧化它们。人们认为对抗微生物的抗微生物作用应该归功于羟基自由基。
抗微生物低聚体的抗微生物作用以抗微生物低聚体的直接杀微生物剂(microbicide)作用为基础,其能够以低速且少量地离开载体材料的聚合物基质,由此以储库(depot)或延迟(retard)化合物的形式释放所述杀微生物剂作用。优选的是抗微生物低聚体由从包括以下的组中选择的一个或多个单体制成:甲基丙烯酸-2-叔丁基氨基乙酯,甲基丙烯酸-2-二乙基氨基乙酯,甲基丙烯酸-2-二乙基氨基甲酯,丙烯酸-2-叔丁基氨基乙酯,丙烯酸-3-二甲基氨基丙酯,丙烯酸-2-二乙基氨基乙酯,丙烯酸-2-二甲基氨基乙酯,二甲基氨基丙基甲基丙烯酰胺,二乙基氨基丙基甲基丙烯酰胺,丙烯酸-3-二甲基氨基丙基酰胺,2-甲基丙烯酰氧基乙基三甲基甲基硫酸铵,甲基丙烯酸-2-二乙基氨基乙酯,2-甲基丙烯酰氧基乙基三甲基氯化铵,3-甲基丙烯酰氨基丙基三甲基氯化铵,2-甲基丙烯酰氧基乙基三甲基氯化铵,2-丙烯酰氧基乙基-4-苯甲酰基二甲基溴化铵,2-甲基丙烯酰氧基-乙基-4-苯甲酰基二甲基溴化铵,烯丙基三苯基溴化鏻,烯丙基三苯基氯化鏻,2-丙烯酰胺基-2-甲基-1-丙烷磺酸,2-二乙基氨基乙基-乙烯基醚和/或3-氨基丙基乙烯基醚。
图5A和图5B示出了将纯的/未结合的纳米粒子并入载体材料的栅格结构中以及将包含抗微生物活性剂的添加剂并入载体材料的栅格结构中。
此作用主要地在于并入的纳米颗粒由于它们的尺寸能够从载体材料的栅格结构逃逸的事实,然而此抗微生物添加剂将活性剂直接并入此栅格结构中,并且基于它们的尺寸将它们锚定在载体材料的栅格结构中(参见图5A和图5B)。
这里,可以通过诸如在二氧化钛的实例中的光催化原理以及借助于通过金属胶体产生的金属离子的抗微生物作用实现微生物的功效并且使其持续地排放到周围环境。金属胶体仅具有几纳米的尺寸并且由于尺寸与表面面积之间的特定比率可以实现长期作用。形成金属离子的金属消耗是非常低的。这允许实现持续超过几年的长期效果。
附图标记列表
1 动脉血导管
2 蠕动泵
3 动脉压传感器
4 高压血液导管
5 动脉血液收集器
6 供给线
7 泵
8 导管
9 透析器
10 透析液供给线
11 透析液排放线
12 血液排放线
13 静脉压收集器
14 防气阀
15 静脉压传感器
16 静脉血导管
17 控制单元
100 壳体
Claims (7)
1.一种用于体外血液处理的医疗装置,其包括抗微生物表面涂层,其特征在于所述抗微生物表面涂层是粉末涂层,其中所述粉末涂层包括具有抗微生物作用的添加剂,其中所述添加剂是具有电离作用和光催化作用的有机金属物质,使得由所述添加剂产生离子和自由基,所述离子和自由基各自由所述粉末涂层发射,其中所述粉末涂层包括附着有所述添加剂的载体材料,所述载体材料具有格栅结构,并且所述添加剂和所述格栅结构的尺寸设置成使得所述添加剂锚定在所述载体材料的栅格结构中。
2.根据权利要求1所述的医疗装置,其特征在于所述粉末涂层涂覆在金属表面上并且/或者所述医疗装置包括装置壳体(100)并且所述粉末涂层至少部分地涂覆在所述装置壳体(100)上。
3.根据权利要求1所述的医疗装置,其特征在于所述添加剂被并入所述粉末涂层中。
4.根据权利要求1所述的医疗装置,其特征在于所述有机金属物质是具有杀微生物剂作用的低聚物。
5.根据权利要求1所述的医疗装置,其特征在于所述粉末涂层包括附着有离子发射体和/或光催化剂的载体物质。
6.一种用于控制根据上述权利要求中任一项的医疗装置的表面上的微生物的方法,其中由所述医疗装置的所述粉末涂层的所述添加剂产生并发射离子和自由基,所述离子和自由基攻击微生物的新陈代谢***。
7.根据权利要求6所述的方法,其特征在于所述添加剂以持续方式产生和/或发射所述离子和自由基。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102016108198.1 | 2016-05-03 | ||
DE102016108198.1A DE102016108198A1 (de) | 2016-05-03 | 2016-05-03 | Medizintechnisches Gerät mit antimikrobieller Oberflächenbeschichtung sowie Verfahren zur Bekämpfung von Mikroorganismen auf der Oberfläche eines solchen Geräts |
Publications (2)
Publication Number | Publication Date |
---|---|
CN107441580A CN107441580A (zh) | 2017-12-08 |
CN107441580B true CN107441580B (zh) | 2022-07-29 |
Family
ID=58644879
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710304144.XA Active CN107441580B (zh) | 2016-05-03 | 2017-05-03 | 包括抗微生物表面涂层的医疗装置以及用于控制此装置的表面上的微生物的方法 |
Country Status (5)
Country | Link |
---|---|
US (1) | US10442150B2 (zh) |
EP (1) | EP3241575B1 (zh) |
JP (1) | JP2018008028A (zh) |
CN (1) | CN107441580B (zh) |
DE (1) | DE102016108198A1 (zh) |
Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1280599A (zh) * | 1997-10-03 | 2001-01-17 | 纳幕尔杜邦公司 | 杀微生物粉末涂料组合物及其制备和应用 |
CN1612804A (zh) * | 2001-12-03 | 2005-05-04 | C·R·巴德公司 | 抗微生物医用器材、抗微生物聚合物涂层及其制备方法 |
CN1629226A (zh) * | 2003-12-19 | 2005-06-22 | 中国印钞造币总公司 | 表面涂层组合物 |
CN101116446A (zh) * | 2006-08-04 | 2008-02-06 | 北京化工大学 | 一种抗菌防霉剂的制备方法 |
CN101142139A (zh) * | 2005-02-11 | 2008-03-12 | Eth苏黎世公司 | 通过火焰喷雾热解制备的抗微生物和抗真菌粉末 |
CN101541181A (zh) * | 2006-01-27 | 2009-09-23 | 史密夫及内修公开有限公司 | 抗微生物材料 |
CN101588722A (zh) * | 2007-01-23 | 2009-11-25 | 默克专利股份有限公司 | 包含氧化锌、硫酸钡和银离子的抗微生物组合物 |
CN101617002A (zh) * | 2006-12-22 | 2009-12-30 | 纳幕尔杜邦公司 | 用于制备抗微生物粉末涂层组合物的方法 |
CN101820766A (zh) * | 2007-10-03 | 2010-09-01 | 3M创新有限公司 | 限制微生物生长的方法 |
CN102182069A (zh) * | 2010-12-30 | 2011-09-14 | 洪桂焕 | 一种载银抗菌整理剂及其制备方法 |
US8063116B2 (en) * | 2006-08-25 | 2011-11-22 | Sciessent Llc | Antimicrobial powder coatings and method |
CN102271826A (zh) * | 2008-12-01 | 2011-12-07 | 贝克顿·迪金森公司 | 对医疗器材施涂抗微生物涂料的***和方法 |
CN102775646A (zh) * | 2011-05-12 | 2012-11-14 | 北京化工大学 | 一种壳聚糖多胺衍生物-载银纳米二氧化钛复合材料 |
CN103012962A (zh) * | 2012-11-09 | 2013-04-03 | 高润宝 | 新型纳米Ag/TiO2改性抗菌、阻燃聚丙烯塑料的制备方法 |
CN105377749A (zh) * | 2013-05-06 | 2016-03-02 | 巴伊兰大学 | 掺杂的金属氧化物纳米颗粒和其用途 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10168346A (ja) * | 1996-12-13 | 1998-06-23 | Kansai Paint Co Ltd | 抗菌性粉体塗料 |
DE19935230C2 (de) * | 1999-07-28 | 2003-06-26 | Kallies Feinchemie Ag | Biofilmhemmendes Mittel |
US6342212B1 (en) * | 2000-09-01 | 2002-01-29 | Milliken & Company | Antimicrobial adhesive latexes and methods of making thereof |
CN1177534C (zh) * | 2000-09-27 | 2004-12-01 | 北京市建筑材料科学研究院 | 载银络合离子坡缕石型无机抗菌剂 |
US8309117B2 (en) * | 2002-12-19 | 2012-11-13 | Novartis, Ag | Method for making medical devices having antimicrobial coatings thereon |
DE102005042181B4 (de) | 2004-09-03 | 2021-02-04 | Löwenstein Medical Technology S.A. | Formkörper sowie Verfahren zur Herstellung eines Formkörpers |
EP1901723B9 (en) * | 2005-06-27 | 2011-09-14 | Smith & Nephew, PLC | Antimicrobial materials |
DE202005014409U1 (de) * | 2005-09-13 | 2005-12-22 | Richard Wöhr GmbH | Massive, durchgehend folienabgedeckte Gehäuseschale und/oder Gehäusefront mit antibakterieller Beschichtung |
CN100493696C (zh) * | 2005-10-27 | 2009-06-03 | 南京大学 | 掺杂纳米氧化锌及其制备方法和光催化降解有机物和抗菌的应用 |
US20070218095A1 (en) * | 2006-03-14 | 2007-09-20 | 3M Innovative Properties Company | Photocatalytic substrate with biocidal coating |
WO2008043396A1 (en) * | 2006-10-12 | 2008-04-17 | Nm Tech Nanomaterials Microdevice Technology Ltd. | Material, item and products comprising a composition having anti-microbial properties |
CN101195719B (zh) * | 2006-12-05 | 2010-11-10 | 曹文 | 纳米抗菌防霉涂料 |
US20090024096A1 (en) * | 2007-07-20 | 2009-01-22 | Baxter International Inc. | Immobilization of dyes and antimicrobial agents on a medical device |
US9125973B2 (en) * | 2007-07-20 | 2015-09-08 | Baxter International Inc. | Antimicrobial housing and cover for a medical device |
JP2009132789A (ja) * | 2007-11-29 | 2009-06-18 | Toshiba Corp | 浴室用コーティング剤 |
EP2108386A1 (de) * | 2008-04-08 | 2009-10-14 | Bayer MaterialScience AG | Medizinische Geräte mit einer antimikrobiellen Polyurethanharnstoffbeschichtung |
EP2108383A1 (de) * | 2008-04-08 | 2009-10-14 | Bayer MaterialScience AG | Medizinische Geräte mit einer antibakteriellen Polyurethanharnstoffbeschichtung |
KR20100126208A (ko) * | 2009-05-21 | 2010-12-01 | 조지아 테크 리서치 코포레이션 | 항미생물성 자외선 역변환 조성물 |
US9284487B2 (en) * | 2010-01-13 | 2016-03-15 | The Penn State Research Foundation | Up-conversion luminescent coatings/materials for antimicrobial applications |
CN101773147B (zh) * | 2010-01-27 | 2012-06-27 | 中南大学 | 一种改性T-ZnOw抗菌材料及其制备方法 |
CN102219179B (zh) * | 2010-04-19 | 2012-12-26 | 中国科学院理化技术研究所 | 一种银掺杂二氧化钛薄膜及其制备方法 |
CN103442567B (zh) * | 2011-03-23 | 2016-02-10 | 巴斯夫欧洲公司 | 含有包含咪唑鎓基团的聚合离子型化合物的组合物 |
US9259513B2 (en) * | 2011-06-20 | 2016-02-16 | Sri International | Photocatalytic disinfection of implanted catheters |
US9220814B2 (en) * | 2011-09-29 | 2015-12-29 | Ethicon, Inc. | Broad-spectrum antimicrobial compositions based on combinations of taurolidine and protamine and medical devices containing such compositions |
US20130085439A1 (en) * | 2011-09-30 | 2013-04-04 | Tyco Healthcare Group Lp | Device to encourage blood circulation between dialysis |
AU2013252461A1 (en) * | 2012-04-24 | 2014-12-04 | Aereus Technologies Inc. | Coatings, coated surfaces, and methods for production thereof |
DE102014215353A1 (de) * | 2014-08-04 | 2016-02-04 | Aesculap Ag | Antimikrobieller Sterilcontainer |
CN104151998B (zh) * | 2014-08-21 | 2016-06-29 | 灵汇技术股份有限公司 | 一种耐洗刷复合抗菌金属涂料及其制备方法 |
CN105419559B (zh) * | 2015-11-25 | 2018-10-19 | 浙江华彩新材料有限公司 | 一种防污抗菌电子元件荧光粉末涂料及其制备方法 |
CN105368274A (zh) * | 2015-11-25 | 2016-03-02 | 安徽圣德建材科技有限公司 | 一种耐磨防水抗菌性粉末涂料 |
-
2016
- 2016-05-03 DE DE102016108198.1A patent/DE102016108198A1/de not_active Withdrawn
-
2017
- 2017-04-25 EP EP17168047.3A patent/EP3241575B1/de active Active
- 2017-04-25 JP JP2017086256A patent/JP2018008028A/ja active Pending
- 2017-04-27 US US15/499,093 patent/US10442150B2/en active Active
- 2017-05-03 CN CN201710304144.XA patent/CN107441580B/zh active Active
Patent Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1280599A (zh) * | 1997-10-03 | 2001-01-17 | 纳幕尔杜邦公司 | 杀微生物粉末涂料组合物及其制备和应用 |
CN1612804A (zh) * | 2001-12-03 | 2005-05-04 | C·R·巴德公司 | 抗微生物医用器材、抗微生物聚合物涂层及其制备方法 |
CN1629226A (zh) * | 2003-12-19 | 2005-06-22 | 中国印钞造币总公司 | 表面涂层组合物 |
CN101142139A (zh) * | 2005-02-11 | 2008-03-12 | Eth苏黎世公司 | 通过火焰喷雾热解制备的抗微生物和抗真菌粉末 |
CN101541181A (zh) * | 2006-01-27 | 2009-09-23 | 史密夫及内修公开有限公司 | 抗微生物材料 |
CN101116446A (zh) * | 2006-08-04 | 2008-02-06 | 北京化工大学 | 一种抗菌防霉剂的制备方法 |
US8063116B2 (en) * | 2006-08-25 | 2011-11-22 | Sciessent Llc | Antimicrobial powder coatings and method |
CN101617002A (zh) * | 2006-12-22 | 2009-12-30 | 纳幕尔杜邦公司 | 用于制备抗微生物粉末涂层组合物的方法 |
CN101588722A (zh) * | 2007-01-23 | 2009-11-25 | 默克专利股份有限公司 | 包含氧化锌、硫酸钡和银离子的抗微生物组合物 |
CN101820766A (zh) * | 2007-10-03 | 2010-09-01 | 3M创新有限公司 | 限制微生物生长的方法 |
CN102271826A (zh) * | 2008-12-01 | 2011-12-07 | 贝克顿·迪金森公司 | 对医疗器材施涂抗微生物涂料的***和方法 |
CN102182069A (zh) * | 2010-12-30 | 2011-09-14 | 洪桂焕 | 一种载银抗菌整理剂及其制备方法 |
CN102775646A (zh) * | 2011-05-12 | 2012-11-14 | 北京化工大学 | 一种壳聚糖多胺衍生物-载银纳米二氧化钛复合材料 |
CN103012962A (zh) * | 2012-11-09 | 2013-04-03 | 高润宝 | 新型纳米Ag/TiO2改性抗菌、阻燃聚丙烯塑料的制备方法 |
CN105377749A (zh) * | 2013-05-06 | 2016-03-02 | 巴伊兰大学 | 掺杂的金属氧化物纳米颗粒和其用途 |
Also Published As
Publication number | Publication date |
---|---|
JP2018008028A (ja) | 2018-01-18 |
EP3241575A1 (de) | 2017-11-08 |
DE102016108198A1 (de) | 2017-11-09 |
EP3241575B1 (de) | 2021-06-02 |
US20170321067A1 (en) | 2017-11-09 |
CN107441580A (zh) | 2017-12-08 |
US10442150B2 (en) | 2019-10-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1409037B1 (en) | Medical devices containing antimicrobial agents having a surfactant surface | |
US5516480A (en) | Bactericidal and/or fungicidal plastic parts for use in the medical field | |
Sousa et al. | Mini-review: antimicrobial central venous catheters–recent advances and strategies | |
AU2009271513B2 (en) | Methods for making antimicrobial resins | |
Alvarez-Lorenzo et al. | Medical devices modified at the surface by γ-ray grafting for drug loading and delivery | |
US10709819B2 (en) | Method for coating catheters with a layer of antimicrobial agent | |
US20070134307A1 (en) | Antimicrobial composite and method of manufacture and use | |
Baek et al. | In situ assembly of antifouling/bacterial silver nanoparticle-hydrogel composites with controlled particle release and matrix softening | |
Mitra et al. | Scalable aqueous-based process for coating polymer and metal substrates with stable quaternized chitosan antibacterial coatings | |
JP2019196544A (ja) | 金属ナノ粒子を含有する抗菌超吸収性高分子吸収材の製造方法 | |
EP3160523B1 (en) | Antimicrobial compositions utilizing silver and oxygen, process for making, and method of using the same | |
CN107441580B (zh) | 包括抗微生物表面涂层的医疗装置以及用于控制此装置的表面上的微生物的方法 | |
JP2017529113A5 (zh) | ||
Karademir et al. | Antimicrobial Surface Functionality of PEG Coated and AgNPs Immobilized Extracorporeal Biomaterials | |
Muge Sahin et al. | Nanostructured biomaterials with antimicrobial properties | |
CN107073148B (zh) | 具有抗微生物处理的导管 | |
EP3010942B1 (en) | Surface modification of medical or veterinary devices | |
Montazer et al. | Antibacterial nanocoatings | |
Tiller | Coatings for prevention or deactivation of biological contamination | |
López-Saucedo et al. | Functionalization of sutures | |
AU2013207646B2 (en) | Antimicrobial resins | |
Farah et al. | Catheters with Antimicrobial Surfaces | |
SMN Mydin et al. | Advantage of Polymer Nanocomposite for Biomedical Application | |
KR20060081912A (ko) | 나노 실버 배관 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |