CN1612804A - 抗微生物医用器材、抗微生物聚合物涂层及其制备方法 - Google Patents

抗微生物医用器材、抗微生物聚合物涂层及其制备方法 Download PDF

Info

Publication number
CN1612804A
CN1612804A CNA02826715XA CN02826715A CN1612804A CN 1612804 A CN1612804 A CN 1612804A CN A02826715X A CNA02826715X A CN A02826715XA CN 02826715 A CN02826715 A CN 02826715A CN 1612804 A CN1612804 A CN 1612804A
Authority
CN
China
Prior art keywords
coat
medical devices
antimicrobial
coating
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA02826715XA
Other languages
English (en)
Inventor
R·N·特里
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CR Bard Inc
Original Assignee
CR Bard Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CR Bard Inc filed Critical CR Bard Inc
Publication of CN1612804A publication Critical patent/CN1612804A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A61L2300/608—Coatings having two or more layers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/622—Microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/08—Coatings comprising two or more layers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/25—Web or sheet containing structurally defined element or component and including a second component containing structurally defined particles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31507—Of polycarbonate
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31551—Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31652—Of asbestos
    • Y10T428/31663—As siloxane, silicone or silane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31678—Of metal
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31721—Of polyimide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31725—Of polyamide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31786—Of polyester [e.g., alkyd, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31855—Of addition polymer from unsaturated monomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)

Abstract

本发明提供了抗微生物的医用器材和制备这些医用器材的方法。在所述器材的至少一部分表面上涂覆一层底涂层。该底涂层包括保持在所述底涂层中的一种或多种类型的抗微生物颗粒。在至少一部分所述底涂层上涂覆聚合物顶涂层。所述顶涂层可为有机可溶性聚合物、水溶性聚合物、水凝胶或能够涂覆在医用器材上的任何其它聚合物。所述顶涂层的聚合物可溶解于在涂覆顶涂层过程中不溶解聚合物底涂层的溶剂中。通过在罩涂过程中不溶解所述底涂层，所述顶涂层保持不含抗微生物颗粒。

Description

抗微生物医用器材、抗微生物聚合物 涂层及其制备方法
发明领域
本发明涉及人或动物内用或外用的带涂层的抗微生物医用器材，和这些医用器材的制备方法。
相关申请的交叉引用
本发明与2001年12月3日申请的US临时申请60/336755相关，并要求其中请日利益，通过引用将其结合在这里。
发明背景
病人治疗用的医用器材可成为在这些病人中的微生物(细菌或真菌)感染源。例如，在病人体内***或植入导管可引入微生物，和/或当长时间留在原处时，在长时间将导管出口部位暴露于环境的过程中可能引入微生物。另外，长时间使用导管经常在导管表面上产生生物膜，其促进感染的发生，而感染可引起病人不适和危及病人健康。
通过在医用器材上结合抗菌剂可防止微生物感染。例如，US专利5476509公开了一种具有聚合物涂层的导管，所述涂层具有与之共价或离子键合的抗菌素。类似的，US专利5798115公开了一种具有聚合物涂层的导管，所述涂层具有共价键合到所述聚合物主链上的抗菌素。长期与这些导管接触的细菌可被杀灭。然而，这些导管对于杀灭在***导管过程中引入到身体中的细菌是无效的。由于抗菌素附着在导管上，细菌可离开导管以逃避抗菌素的作用。
在US专利5019096中叙述了一种涂覆有形成基质的聚合物的抗微生物导管，在所述聚合物涂层中引入了一种抗菌剂。因为所述抗菌素不是与所述聚合物共价键合，它能够自所述导管扩散来攻击在周围区域中的生物体。
但是，通过不溶性颗粒(即不溶于用于涂覆医用器材的溶剂中的颗粒)将抗菌剂引入到医用器材涂层中产生了令人不满意的效果，特别是当使用浸涂或喷雾涂覆技术来涂覆医用器材时。例如，不溶性抗菌剂颗粒趋向于从涂覆过程中使用的溶液中沉降出来。当颗粒从溶液中沉降出来时，在所得涂层中的抗微生物颗粒的浓度在制备过程中随时间推移而降低，从而降低了生产者控制在所述器材上的抗菌剂浓度的能力。
另外，所述抗微生物颗粒可在涂覆溶液中聚集成较大的颗粒(从尺寸小于4微米至尺寸为10至100微米或更大)。这可产生大至足以在涂覆过的器材表面被感觉到的颗粒，而且如果其足够大，这些聚集的颗粒可导致病人不适。例如，在将福利导尿管***到尿道中时，大于约50微米的颗粒通常可被病人感觉到。
小于50微米的颗粒也可产生问题。虽然10至50微米范围的较小颗粒不易被病人感觉到，但显微检测表明，这些颗粒产生不平的或微观粗糙的涂层表面。微观粗糙的表面具有比光滑涂覆的表面更高的表面积，并且这往往增加细菌和其它微生物的附着性。附着微生物的增加的表面积和由于粗糙的导管表面所致的增加的组织刺激显著降低了所述抗微生物涂层抵御感染的能力。因而，需要消除不溶性抗微生物颗粒的聚集对带涂层的医用器材的性能可能产生的潜在不利影响。
与不溶性抗微生物颗粒相关的问题特别与涂覆在导管，尤其是福利导尿管上的抗菌素涂层相关。
发明简述
为解决与在医用器材涂层中引入一种或多种类型的抗微生物颗粒有关的问题，本发明提供了抗微生物的医用器材和制备这些医用器材的方法。
在第一方面中，本发明提供了一种抗微生物的医用器材。一层底涂层涂覆在所述器材的至少一部分表面上。所述底涂层可以是能够被涂覆在医用器材上的任何聚合物材料。
所述底涂层包括保持在该底涂层中的一种或多种类型的抗微生物颗粒。所述颗粒可以是不溶性的抗微生物颗粒，当所述涂层与含水流体接触时，所述抗微生物颗粒能够释放出可诱导微生物停滞(stasis)或表现出杀微生物效果的试剂。“不溶性”是指这些抗微生物颗粒不能溶解于本发明所使用的溶剂体系中。
在至少一部分所述底涂层上涂覆聚合物顶涂层。所述顶涂层可以是可溶于有机物中的聚合物、水溶性聚合物、水凝胶或能够涂覆在医用器材上的任何其它聚合物。顶涂层的聚合物在顶涂层涂覆过程中可溶于不能溶解聚合物底涂层的溶剂中。因而，顶涂层保持基本不上含抗微生物颗粒。这通过避免与抗微生物颗粒聚集和不平或微观粗糙的涂层表面有关的以上讨论的问题，给病人提供了增加的舒适性。
在第二方面中，本发明提供了抗微生物的聚合物涂层。这种涂层具有包含一种或多种类型的抗微生物颗粒的聚合物底涂层。聚合物顶涂层被涂覆在至少一部分底涂层上，并且通过在顶涂层涂覆过程中不溶解所述底涂层而保持基本不上含抗微生物颗粒。
在第三方面中，本发明提供了一种制备抗微生物的医用器材的方法。按照这种方法，提供了一种医用器材。将第一聚合物溶解在第一聚合物溶液中。将一种或多种抗微生物颗粒分散在所述第一聚合物溶液中，以形成第一涂覆溶液。将所述第一涂覆溶液涂覆在至少一部分医用器材上以形成一种底涂层。这种涂覆可是喷涂或浸涂中的任一种。然后，将第二聚合物溶解在第二溶剂体系中，以形成第二涂覆溶液。在将顶涂层涂覆在所述医用器材上的过程中，这种第二溶剂体系在通常的作用时间内不溶解所述的底涂层。涂覆第二涂层以覆盖至少一部分所述底涂层，从而形成保持基本不上含抗微生物颗粒的顶涂层。这种涂覆也可以是喷涂或浸涂中的任一种。
在第四方面中，本发明提供了一种在抗微生物的医用器材上涂覆顶涂层的方法。按照这种方法，提供了一种抗微生物的医用器材(即，至少部分被聚合物底涂层包覆的器材，该聚合物底涂层具有在该底涂层中的一种或多种抗微生物颗粒)。然后，将顶涂层聚合物溶解在一种溶剂体系中，在将顶涂层涂覆在所述医用器材上的过程中，所述溶剂体系不溶解所述的底涂层。涂布所述顶涂层聚合物以覆盖至少一部分所述抗微生物的医用器材。所述顶涂层基本上不含抗微生物颗粒。在涂覆顶涂层过程中，所述底涂层不溶解。
如上所述形成的医用器材具有降低的微观粗糙度，因为在顶涂层覆盖处，不会裸露抗微生物颗粒。另外，所述顶涂层可提供滑润性和病人舒适性，并能控制抗菌剂的释放。
发明的详细说明
本发明的抗微生物的医用器材包括具有一种或多种类型的抗微生物颗粒的底涂层和提供在至少一部分所述底涂层上的顶涂层。
医用器材是接触病人或用于健康保健的任何制品，并可以是内用的或外用的。所述医用器材可由各种天然或合成材料来制备，所述材料例如是胶乳、聚苯乙烯、聚酯、聚氯乙烯、聚氨酯、ABS聚合物、聚酰胺、聚酰亚胺、聚碳酸酯、聚丙烯酸酯、聚乙烯、聚丙烯、合成橡胶、不锈钢、陶瓷如氧化铝和玻璃、和聚硅氧烷。
例举性的、非限定性的实例包括套管、导管、避孕套、隐形眼镜、气管内和胃肠饲管以及其它管、移植物、导线、植入装置、宫内节育器、医用手套、氧合器和肾膜(kidney membranes)、起搏器导联、蠕动泵室、分流器(shunts)、支架和缝合线。
所述抗微生物颗粒可以是当以有效量存在时释放出能够诱导微生物停滞或表现出杀微生物作用的试剂的任何物质。确定微生物停滞或杀微生物作用的方法是本领域中公知的，包括例如测量带涂层的导管提取物的最小抑制浓度、抑制试验区和细菌粘附试验，对所有试验使用公知的临床病原体。
所述抗微生物颗粒可是具有微动性能的金属和金属盐、氧化物和络合物，如铝、锑、铋、铈、铜、金、铱、镁、汞、钯、铂、银、锡和锌及它们的盐、氧化物、络合物和它们的混合物。所述抗微生物颗粒可是相同的物质(如银沸石)或可是不同的(如银沸石和碘化银的混合物)。所述颗粒可具有高达约100微米的平均颗粒大小。优选所述抗微生物颗粒具有的平均颗粒大小小于约10微米，最优选小于约4微米。
例如，所述抗微生物颗粒包括但不限于：铜及其盐，如乙酸铜、氯化铜、溴化铜、氯酸铜、高氯酸铜、亚硝酸铜和硝酸铜、硫酸铜，及其它铜盐和络合物，和银及其盐，如乙酸银、苯甲酸银、氯化银、碳酸银、碘酸银、碘化银、乳酸银、月桂酸银、氧化银、棕榈酸银、蛋白银、磺胺嘧啶银、氯化银/二氧化钛络合物、银沸石，及其它银盐和络合物。还可使用其它非含铜和非含银的抗微生物颗粒。
在某些实施方案中，所述抗微生物颗粒可具有大于50微米的平均颗粒大小。虽然通常优选抗微生物颗粒的平均颗粒大小小于约4微米，但在某些情况下，在底涂层中引入这种较大的抗微生物颗粒可能是有利的。通过使用顶涂层，在仍然充许使用这种较大的抗微生物颗粒的条件下，提供了提高的病人舒适性。
所述底涂层可以是能够涂覆在医用器材表面上并能够引入抗微生物颗粒的任何聚合物。底涂层聚合物包括有机可溶性聚合物、水溶性聚合物和水凝胶。用于底涂层的聚合物的例举性实例是聚氨酯、聚脲、聚氨酯-脲、丙烯酸类共聚物、它们的组合物和/或由它们衍生的嵌段共聚物。聚氨酯底涂层的实例公开在US专利3822238；3975350；4156066；4156067；4255550；4359558；4729914；4789720和4810543中，所述专利结合在这里。
可通过浸涂将所述底涂层涂覆在所述医用器材上。难以涂覆的聚合物(即聚乙烯、聚丙烯和聚四氟乙烯)也可用于本发明。所述聚合物底涂层可呈预先形成的聚合物来涂覆，或者可通过在医用器材表面上对单体进行聚合来得到。
所述顶涂层也是一种聚合物，并涂覆在含抗微生物颗粒的至少一部分底涂层上。所述顶涂层可以是任何有机可溶性聚合物、水溶性聚合物、水凝胶或能够涂覆在医用器材上的任何其它聚合物。可接受的聚合物包括如下聚合物材料：聚氨酯、聚氨酯-脲、聚乙烯基吡咯烷酮、聚环氧乙烷、聚丙烯酸、甲基丙烯酸羟乙基酯、羧甲基纤维素、聚乙烯醇、聚丙烯酰胺、葡聚糖和其它多糖、淀粉、瓜耳胶、黄原胶和其它胶和增稠剂、胶原、明胶和其它生物聚合物。几乎任何可溶解于溶剂中的亲水性聚合物都可用于所述顶涂层。
水凝胶优选具有约25wt％至约500wt％、更优选具有约50wt％至约200wt％、最优选具有约75wt％至约150wt％的水保留量。所述水凝胶可衍生自水溶性聚合物，所述水溶性聚合物包括但非仅限于聚(环氧乙烷)、聚(乙二醇)、聚(乙烯醇)、聚乙烯基吡咯烷酮、聚(乙基噁唑啉)、聚氨基酸、假聚氨基酸，以及这些物质互相或与其它水溶性聚合物的混合物。
这些水溶性水凝胶聚合物可与第二种聚合物络合、共价连接或共聚合，所述第二种聚合物是例如聚氨酯、聚脲或聚氨酯-脲，以及这些物质互相或与其它聚合物的混合物。所述第二种聚合物可以以预先形成的聚合物的形式添加，或者其可在水溶性聚合物存在下由单体聚合来得到。所述聚合反应可在对基材涂覆之前或之后进行。
另外，与底涂层聚合物相似，所述顶涂层聚合物对由抗微生物颗粒释放的试剂而言是可渗透或半渗透的。为了提供抗微生物性，所述抗微生物颗粒向周围流体或组织中释放抗菌剂。
再有，选择顶涂层聚合物，使得在涂覆过程中顶涂层能够溶解在一种溶剂体系中，而该溶剂体系在正常涂覆过程中不能溶解所述底涂层。例如，所述底涂层可以是不溶于醇中的聚氨酯树脂，而顶涂层可是聚乙烯基吡咯烷酮，一种醇溶性聚合物。
虽然在浸涂过程中底涂层不溶于顶涂层溶剂体系中，但它应充分溶胀以在所述底涂层和顶涂层之间形成互穿网络。这提供了涂层粘合力。但是，所述底涂层不应溶解或向顶涂层释出任何显著数量的抗微生物颗粒。如在所述顶涂层中存在，所述抗微生物颗粒不应通过造成不平或微观粗糙的器材表面而损害病人的舒适性。如下所述，消除或至少减少抗微生物颗粒浸出到顶涂层溶液中还使制备更容易。
如本领域技术人员可理解的，用于所述底涂层或顶涂层的溶剂体系包括在适当的工艺条件下能够溶解这些聚合物的任何有机或无机溶剂、水基溶剂或这些物质的组合。溶剂的非限定性实例包括丙酮、乙腈、苯胺、苯、丁醇、二硫化碳、四氯化碳、氯仿、环己烷、二甲基乙酰胺、二甲亚砜、二甲基甲酰胺、二噁烷、乙醇、乙酸乙酯、乙二醇、己烷、异丙醇、甲醇、二溴甲烷、二氯甲烷、甲乙酮、硝基乙烷、吡啶、四氢呋喃、1，2，3，4-四氢化萘、甲苯、三氯乙烯和水。
本发明的医用器材通过在所述器材上涂覆包括抗微生物颗粒的聚合物底涂层、然后用聚合物在所述器材上涂覆顶涂层来制备，所述顶涂层聚合物的选择使得它可溶解在在溶液涂覆过程中不溶解所述底涂层的溶剂中。
通过本领域已知的方法来涂覆所述底涂层，包括浸涂和喷涂。通常，这些方法包括将一种聚合物溶解于一种溶剂体系中，将抗微生物颗粒分散于所得到的聚合物溶液中，和然后将该聚合物溶液浸涂或喷涂在医用器材上。然后，使带有底涂层的医用器材干燥，所述干燥在室温或控制的温度下或这两种条件下进行。
以前，将顶涂层涂覆在这种带有底涂层的医用器材上一直是有问题的。尤其是，当浸涂一系列医用器材时，如果底涂层在被涂以顶涂层时甚至是微量的溶解，则抗微生物颗粒可能会在顶涂层涂料中积累。如发生这种情况，则所述抗微生物颗粒将开始聚集在顶涂层溶液中，随着被浸涂的器材数量的增加，导致在顶涂层中抗微生物颗粒浓度增加。另外，被萃取到顶涂层溶液中的抗微生物颗粒可以在顶涂层中聚集成较大的颗粒，引起微观粗糙。结果，当底涂层溶解于顶涂层溶液中时，必须更经常地更换顶涂层溶液。因此，本发明减少了制造成本并通过避免这些问题使制造更容易。
再者，如果在浸涂过程中聚合物底涂层溶解(即进入顶涂层溶液)，顶涂层的性能会受到不良影响。例如，如果底涂层在湿态时不是润滑的，则它可能减少湿态润滑的顶涂层的润滑度，因为其在顶涂层中的浓度随着浸到顶涂层溶液中的带有底涂层的医用器材数量的增加而增加。
为解决这些问题，通过溶液涂覆来将顶涂层涂覆在所述底涂层上，且选择顶涂层的聚合物使得它能够溶解于在溶液涂覆过程中不溶解所述底涂层的溶剂中。如同底涂层那样，一旦医用器材涂覆了顶涂层后，就使其干燥。如上所述，所述顶涂层可通过浸涂或喷涂来进行涂覆。在所述涂覆过程中，所述底涂层不会由于暴露于顶涂层溶剂而溶解。
例如，底涂层使用在含有50％以上变性乙醇的溶剂体系中不溶解的聚氨酯。通过能够溶解在含有85％变性乙醇的溶剂体系中的很亲水的聚氨酯来形成顶涂层。在这种实施方案中，所述顶涂层溶解于含有足够的对底涂层为非溶剂的乙醇的溶剂体系中，当进行顶涂层涂覆时所述非溶剂不溶解所述底涂层。
当亲水性聚合物用于顶涂层时，带有顶涂层的抗微生物医用器材提供了医用器材的增加的表面润滑度和降低的表面积(与底涂层相比)。因而，实现了增加的病人舒适性、降低的组织刺激性和增加的抗微生物有效性。另外，与先前在需要润滑的器材表面的情况下所允许的相比，顶涂层使得可使用更坚固、亲水性更小的底涂层材料。再有，通过选择用于底涂层和顶涂层的聚合物，可改变或控制抗微生物剂的释放速率。
使用顶涂层以及含有抗微生物颗粒的底涂层减少了对底涂层表面粗糙度的关切。因而，在某些实施方案中，在底涂层中存在高浓度的抗微生物颗粒。在所述底涂层中可使用任何浓度的抗微生物颗粒，只要在所述底涂层中有足够的聚合物来将所述颗粒保持在原位。例如，所述底涂层可具有浓度高达约75wt％，更优选高达约50wt％，最优选约30至约50wt％的抗微生物颗粒。
在某些实施方案中，可在医用器材上提供多于一层的顶涂层和一层底涂层。例如，可在医用器材上提供两层顶涂层。在一种这样的实施方案中，可给导管提供设计用来控制抗菌剂自所述底涂层释出速率的第一聚合物顶涂层，和然后提供设计用来使病人舒适性最大化的第二层聚合物顶涂层。另外，所述第一聚合物顶涂层可设计用来使所述底涂层与第二聚合物顶涂层相容。当在无中间的第一聚合物顶涂层情况下所述底涂层与所述第二聚合物顶涂层不能充分互相粘附时，这可能是有利的。
在其它实施方案中，医用器材可具有两层底涂层。这可允许例如在所述两层底涂层中使用两种不同的抗微生物颗粒，当这些抗微生物颗粒不能被用在一个底涂层中时。第一层底涂层可具有一种类型的金属抗微生物颗粒，而第二层底涂层可具有不同类型的金属抗微生物颗粒。当这两种类型的金属抗微生物颗粒置于导电流体(如在各种体流体中)中时，产生原电池。一种金属抗微生物颗粒起阳极作用，第二种金属抗微生物颗粒起阴极作用，以驱动所述电化学池。例如，如果在一个底涂层中使用铜基颗粒并在另一个底涂层中使用银基颗粒，则铜基颗粒起阳极作用，向电解质中释出Cu+离子。更贵的金属银起阴极作用，其不离子化。有利地，与仅使用一种类型的金属抗微生物颗粒相比，这种布置迫使Cu+离子以更大的速率进入周围环境。因此，这是改变或控制抗微生物剂自所述医用器材释出的速率的另一种途径。
可在上述的医用器材中结合各种治疗剂。可给导管提供一种或多种附加的治疗剂。例如，可将液体或固体的可溶性抗微生物剂、抗生素或抗凝血剂单独或呈组合形式结合到顶涂层或底涂层中。另外，还可使用填料、补充剂、熔体流动添加剂、干燥流动添加剂、颜料和其它添加剂，来提高医用器材的具体的物理性能、美感、耐久性或其它属性。
提供如下实施例来举例说明本发明，但无论如何其不应认为是对本发明范围的限制。本领域技术人员会认识到，在不偏离本发明实质的前提下可做出许多改变和替代。因此，应当指出，本发明不局限于这里公开的实施方案，而是应从如下权利要求来理解，所述权利要求应以法律充许的最宽范围来解释。
实施例1
按下述来制备底涂层。通过混合56.25％四氢呋喃(THF)、25％二溴甲烷和18.75％变性乙醇来形成一种溶剂体系。将聚氨酯树脂(由CardioTech International of Woburn，Massachusetts以商标名HMBU出售)以溶液总重量的3.6％的浓度溶解于该溶剂体系中。
将银沸石颗粒(由Applied Surface Technology，Inc.ofLouisville，Kentucky以商标名AGION出售)以干燥涂层重量(HMBU与AGION的总重量)的40％的浓度在所述底涂层溶液中分散总共44分钟。
所述底涂层溶液保持在约23℃温度下，并通过以每分钟40英寸(ipm)的控制速度浸入所述涂覆溶液、允许在所述溶液中溶胀10秒钟并以17ipm的速度从所述溶液中取出，将所述底涂层溶液涂覆在16Fr福利导尿管(由C.R.Bard，Inc.以商标名BARDBX出售)上。
将第二种聚氨酯(由CardioTech以商标名HydroMed D6/40TM出售)在约40℃温度下溶解于15％THF和85％变性乙醇的溶剂体系中，冷却，并保持在约25℃的温度下，以使HydroMed D6/40TM保持在溶液中。然后，通过以40ipm的速度浸入所述溶液、不在溶液中溶胀、并以17ipm的速度取出，对带有底涂层的导管进行顶涂层涂覆。
所述顶涂层溶液产生对涂层粘合力来说足够的底涂层溶胀，但不溶解或侵蚀所述底涂层。与未涂覆顶涂层的导管相比，带有顶涂层的导管具有降低的微观粗糙度，并在所述导管的内表面和外表面上具有光滑和湿态润滑的涂层。
在与含水流体接触时，如上所述涂覆的导管吸收水分，并且摸起来变得润滑或平滑。涂层的润滑度可通过摩擦系数(COF)试验来测量。
测试如实施例1所述制备的导管的COF。将一对导管间隔2英寸彼此平行设置在水槽中，将包有纤维素膜的400g不锈钢滑板沿平行于所述导管长度的导管轴由漏斗端拉向尖端。在所述导管长度上对拉动所述滑板所需的力进行平均，将这一力除以滑板的重量得到无单位的COF值。
为评价涂层的润滑度和耐久性，在试验过程中将导管在约37℃下在去离子水中培养。在一小时后和在1、7、14和21天后测量COF。
在培养一小时后，实施例1的导管具有的COF为0.06。优选所述一小时的COF为约0.02至约0.15，最优选为约0.02至约0.08。
测量在21天中COF的改变来评价实施例1的导管的耐久性。一般地，如果在21天的试验过程中COF增加很小，则证明了耐久性。实施例1的导管在21天时具有的COF为0.08，而在一小时的读数为0.06。这被认为是耐久的。

Claims (21)

1.一种抗微生物医用器材，包含：
基材；
涂覆在至少一部分所述基材上的聚合物底涂层；
分散在所述底涂层中的至少一种类型的抗微生物颗粒；和
位于至少一部分所述底涂层上的聚合物顶涂层；
其中所述聚合物顶涂层可溶解于在顶涂层涂覆过程中不溶解聚合物底涂层的溶剂中，且其中所述聚合物顶涂层基本上不含抗微生物颗粒。
2.权利要求1的抗微生物医用器材，其中所述基材为选自由以下物质组成的组的材料：胶乳、聚苯乙烯、聚酯、聚氯乙烯、聚氨酯、ABS聚合物、聚酰胺、聚酰亚胺、聚碳酸酯、聚丙烯酸酯、聚乙烯、聚丙烯、合成橡胶、不锈钢、陶瓷、氧化铝、玻璃和聚硅氧烷。
3.权利要求1的抗微生物医用器材，其中所述聚合物底涂层选自由如下物质组成的组：聚氨酯、聚脲、聚氨酯-脲、丙烯酸类共聚物、它们的组合，和由它们衍生的嵌段共聚物。
4.权利要求1的抗微生物医用器材，其中所述抗微生物颗粒是选自由如下物质组成的组的银基化合物：乙酸银、苯甲酸银、氯化银、碳酸银、碘酸银、碘化银、乳酸银、月桂酸银、氧化银、棕榈酸银、蛋白银、磺胺嘧啶银、氯化银/二氧化钛络合物、银沸石和其它银盐和络合物。
5.权利要求1的抗微生物医用器材，其中所述抗微生物颗粒具有最高达约100微米的平均颗粒大小。
6.权利要求1的抗微生物医用器材，其中所述聚合物顶涂层选自由如下物质组成的组：聚氨酯、聚氨酯-脲、聚乙烯基吡咯烷酮、聚环氧乙烷、聚丙烯酸、甲基丙烯酸羟乙基酯、羧甲基纤维素、聚乙烯醇、聚丙烯酰胺、葡聚糖、多糖、淀粉、瓜耳胶、黄原胶和其它胶和增稠剂、胶原和明胶。
7.权利要求1的抗微生物医用器材，其中所述聚合物底涂层是不溶解于醇的聚氨酯树脂，所述聚合物顶涂层是醇溶性的聚乙烯基吡咯烷酮。
8.用于医用器材的抗微生物聚合物涂层，该涂层包含：
具有分散的抗微生物颗粒的聚合物底涂层；和
基本上不含抗微生物颗粒并置于至少一部分所述底涂层上的聚合物顶涂层。
9.权利要求8的抗微生物聚合物涂层，其中所述聚合物底涂层是不溶解于含50％以上变性乙醇的溶剂体系的聚氨酯树脂。
10.权利要求9的抗微生物聚合物涂层，其中所述抗微生物颗粒是银沸石。
11.权利要求10的抗微生物聚合物涂层，其中所述银沸石以聚合物底涂层与抗微生物颗粒总干重的约40％的浓度存在于所述底涂层中。
12.权利要求11的抗微生物聚合物涂层，其中所述顶涂层是能够溶解在含85％变性乙醇的溶剂体系中的聚氨酯。
13.一种制备抗微生物的医用器材的方法，包括：
提供具有表面的医用器材；
将第一聚合物溶解在第一溶剂体系中来制备第一聚合物溶液；
将至少一种类型的抗微生物颗粒分散在第一聚合物溶液中来形成底涂层溶液；
将所述底涂层溶液涂覆在至少一部分所述表面上来形成底涂层；
将第二聚合物溶解于第二溶剂体系中来形成第二聚合物溶液；和
将所述第二聚合物溶液涂覆在至少一部分所述底涂层上，使在涂覆第二聚合物溶液过程中所述底涂层不溶解，并形成基本上不含抗微生物颗粒的顶涂层。
14.权利要求13的制备抗微生物的医用器材的方法，其中所述医用器材选自：套管、导管、避孕套、隐形眼镜、气管内和胃肠饲管以及其它管、移植物、导线、植入装置、宫内节育器、医用手套、氧合器和肾膜、起搏器导联、蠕动泵室、分流器、支架和缝合线。
15.权利要求14的制备抗微生物的医用器材的方法，其中所述医用器材是导尿管。
16.权利要求13的制备抗微生物的医用器材的方法，其中通过浸涂来涂覆所述底涂层。
17.权利要求13的制备抗微生物的医用器材的方法，其中通过喷涂来涂覆所述底涂层。
18.一种罩涂抗微生物的医用器材的方法，所述方法包括：
提供至少部分被聚合物底涂层包覆的抗微生物的医用器材，所述底涂层具有至少一种类型的分散的抗微生物颗粒；
将顶涂层聚合物溶解于在涂覆顶涂层过程中不溶解所述底涂层的溶剂体系中；和
将溶解的顶涂层聚合物涂覆在至少一部分所述抗微生物的医用器材上以形成底涂层，使所述底涂层不溶解且所述顶涂层基本上不含抗微生物颗粒。
19.权利要求18的罩涂抗微生物的医用器材的方法，其中所述不溶解所述底涂层的溶剂体系选自：丙酮、乙腈、苯胺、苯、丁醇、二硫化碳、四氯化碳、氯仿、环己烷、二甲基乙酰胺、二甲基亚砜、二甲基甲酰胺、二噁烷、乙醇、乙酸乙酯、乙二醇、己烷、异丙醇、甲醇、二溴甲烷、二氯甲烷、甲乙酮、硝基乙烷、吡啶、四氢呋喃、1，2，3，4-四氢化萘、甲苯、三氯乙烯和水。
20.权利要求18的罩涂抗微生物的医用器材的方法，其中通过浸涂在所述底涂层上来涂覆所述顶涂层。
21.权利要求18的罩涂抗微生物的医用器材的方法，其中通过喷涂在所述底涂层上来涂覆所述顶涂层。
CNA02826715XA 2001-12-03 2002-12-03 抗微生物医用器材、抗微生物聚合物涂层及其制备方法 Pending CN1612804A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33675501P 2001-12-03 2001-12-03
US60/336,755 2001-12-03

Publications (1)

Publication Number Publication Date
CN1612804A true CN1612804A (zh) 2005-05-04

Family

ID=23317500

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA02826715XA Pending CN1612804A (zh) 2001-12-03 2002-12-03 抗微生物医用器材、抗微生物聚合物涂层及其制备方法

Country Status (8)

Country Link
US (1) US7820284B2 (zh)
EP (1) EP1450866A4 (zh)
JP (1) JP2005511144A (zh)
CN (1) CN1612804A (zh)
AU (1) AU2002357050A1 (zh)
CA (1) CA2468780A1 (zh)
MX (1) MXPA04005332A (zh)
WO (1) WO2003047636A2 (zh)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102170923A (zh) * 2008-09-30 2011-08-31 伊西康公司 用抗感染剂涂覆医疗器件的金属表面的方法
CN102438473A (zh) * 2009-03-11 2012-05-02 安塞尔有限公司 无粉抗微生物涂层手套
CN102639164A (zh) * 2009-10-28 2012-08-15 伊西康公司 具有用于医疗装置的优选微结构的抗微生物涂层
CN102695528A (zh) * 2009-08-21 2012-09-26 诺万公司 创伤敷料、其使用方法及其形成方法
CN103153353A (zh) * 2010-06-04 2013-06-12 史密斯医疗Asd公司 抗菌润滑剂
CN103554542A (zh) * 2013-11-11 2014-02-05 镇江苏惠乳胶制品有限公司 一种乳胶手套的涂层工艺
CN105536073A (zh) * 2015-12-22 2016-05-04 华中科技大学 一种以peo-ldpe合金为基体的含铜节育材料及其器件
CN106075531A (zh) * 2016-06-16 2016-11-09 湖州科达化工燃料有限公司 一种消肿止痛的医用薄膜
US9526738B2 (en) 2009-08-21 2016-12-27 Novan, Inc. Topical gels and methods of using the same
CN106474531A (zh) * 2016-11-09 2017-03-08 泰州市榕兴医疗用品股份有限公司 一种含有抗菌剂的缝合线及制备方法
CN106880876A (zh) * 2017-02-24 2017-06-23 创领心律管理医疗器械（上海）有限公司 一种植入性医疗器械的抗菌涂层的制备方法
CN106938061A (zh) * 2017-04-17 2017-07-11 科睿驰（深圳）医疗科技发展有限公司 一种改善介入器械表面的涂层方法
CN107205956A (zh) * 2014-10-30 2017-09-26 纺织品技术股份有限公司 输送***
CN107441580A (zh) * 2016-05-03 2017-12-08 B·布莱恩·阿维图姆股份公司 包括抗微生物表面涂层的医疗装置以及用于控制此装置的表面上的微生物的方法
CN108066012A (zh) * 2018-01-10 2018-05-25 新乡市华康卫材有限公司 一种医疗用无菌手套
CN109475661A (zh) * 2015-06-08 2019-03-15 奥特克国际公开有限公司 基于硅-聚碳酸酯二醇的聚氨酯溶液的制备方法
CN111909448A (zh) * 2020-07-02 2020-11-10 中国人民解放军西部战区总医院 医用材料、针刺穴位的辅助支架及其制备方法

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7179849B2 (en) 1999-12-15 2007-02-20 C. R. Bard, Inc. Antimicrobial compositions containing colloids of oligodynamic metals
DE10323676A1 (de) * 2003-05-15 2004-12-02 Aesculap Ag & Co. Kg Implantat mit antibiotischer Langzeitwirkung
AT413471B (de) * 2003-05-21 2006-03-15 Semperit Ag Holding Prophylaxeartikel
WO2004103425A1 (en) * 2003-05-23 2004-12-02 Gambro Lundia Ab Biocompatible polymer
SE526027C2 (sv) 2003-05-23 2005-06-14 Gambro Lundia Ab Biokompatibel polymerkomposition, förfarande för beredning av en biokompatibel sampolymerkomposition, artikel med en film av en polymerkomposition och användning av en biokompatibel polymerkomposition för en medicinsk anordning
US8734421B2 (en) * 2003-06-30 2014-05-27 Johnson & Johnson Consumer Companies, Inc. Methods of treating pores on the skin with electricity
US7318945B2 (en) 2003-07-09 2008-01-15 Medtronic Vascular, Inc. Laminated drug-polymer coated stent having dipped layers
US20050058673A1 (en) 2003-09-09 2005-03-17 3M Innovative Properties Company Antimicrobial compositions and methods
DE10353756A1 (de) * 2003-11-17 2005-06-30 Bio-Gate Bioinnovative Materials Gmbh Schichtmaterial
US7745509B2 (en) 2003-12-05 2010-06-29 3M Innovative Properties Company Polymer compositions with bioactive agent, medical articles, and methods
US8414547B2 (en) 2004-04-29 2013-04-09 C. R. Bard, Inc. Modulating agents for antimicrobial coatings
US20080063693A1 (en) 2004-04-29 2008-03-13 Bacterin Inc. Antimicrobial coating for inhibition of bacterial adhesion and biofilm formation
US7976518B2 (en) 2005-01-13 2011-07-12 Corpak Medsystems, Inc. Tubing assembly and signal generator placement control device and method for use with catheter guidance systems
KR20070113281A (ko) 2005-03-10 2007-11-28 쓰리엠 이노베이티브 프로퍼티즈 컴파니 항미생물성 조성물 및 방법
WO2006099359A2 (en) 2005-03-10 2006-09-21 3M Innovative Properties Company Methods of reducing microbial contamination
US20090214618A1 (en) 2005-05-27 2009-08-27 Schoenfisch Mark H Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
WO2007017019A2 (en) * 2005-07-28 2007-02-15 Merck Patent Gmbh Antimicrobial catheters
US20070129690A1 (en) * 2005-12-02 2007-06-07 Joel Rosenblatt Catheter with polymeric coating
AT503090B1 (de) * 2006-01-11 2012-06-15 Semperit Ag Holding Prophylaxeartikel
US20070166399A1 (en) 2006-01-13 2007-07-19 3M Innovative Properties Company Silver-containing antimicrobial articles and methods of manufacture
CA2635932C (en) * 2006-02-23 2014-05-27 E.I. Du Pont De Nemours And Company Removable antimicrobial coating compositions and methods of use
EP2026846A4 (en) * 2006-06-05 2010-09-29 Bactiguard Ab POLYMER MATRIX, USES THEREOF AND METHOD FOR MANUFACTURING THE SAME
US8512294B2 (en) * 2006-07-28 2013-08-20 Becton, Dickinson And Company Vascular access device antimicrobial materials and solutions
DE102006051093B4 (de) * 2006-10-25 2011-03-17 Heraeus Kulzer Gmbh Chirurgisches Nahtmaterial mit antimikrobieller Oberfläche und Verfahren zur antimikrobiellen Beschichtung chirurgischen Nahtmaterials
EP1917984A1 (en) * 2006-10-27 2008-05-07 EMPA Eidgenössische Materialprüfungs- und Forschungsanstalt Coated biomedical device
CN101600526A (zh) 2006-12-08 2009-12-09 东洋制罐株式会社 使微生物蛋白质失活的金属超微粒子
US20080181931A1 (en) * 2007-01-31 2008-07-31 Yongxing Qiu Antimicrobial medical devices including silver nanoparticles
EP2173428B1 (en) * 2007-07-16 2018-10-10 C.R. Bard, INC. Foley catheter having sterile barrier
US20090092538A1 (en) 2007-10-08 2009-04-09 Amit Khanolkar Methods for forming stabilized metal salt particles
US8216629B2 (en) * 2007-10-29 2012-07-10 Advanced Vision Science, Inc. Lubricious intraocular lens insertion device
DE102008001014A1 (de) * 2008-04-04 2009-10-08 Bio-Gate Ag Schichtmaterial
US9427297B2 (en) * 2008-05-09 2016-08-30 Boston Scientific Scimed, Inc. Surgical meshes with radiopaque coatings
US8178120B2 (en) * 2008-06-20 2012-05-15 Baxter International Inc. Methods for processing substrates having an antimicrobial coating
US8753561B2 (en) * 2008-06-20 2014-06-17 Baxter International Inc. Methods for processing substrates comprising metallic nanoparticles
US8277826B2 (en) 2008-06-25 2012-10-02 Baxter International Inc. Methods for making antimicrobial resins
US20090324738A1 (en) * 2008-06-30 2009-12-31 Baxter International Inc. Methods for making antimicrobial coatings
US8361139B2 (en) 2008-07-16 2013-01-29 Boston Scientific Scimed, Inc. Medical devices having metal coatings for controlled drug release
US20100082088A1 (en) * 2008-08-27 2010-04-01 Ali Fassih Treatment of sweating and hyperhydrosis
EP2177238B1 (en) * 2008-10-14 2016-11-09 Dentsply IH AB Medical device with controllably releasable antibacterial agent
WO2010090098A1 (ja) * 2009-02-09 2010-08-12 テルモ株式会社 抗菌性医療器具の製造方法および抗菌性医療器具
US20100227052A1 (en) * 2009-03-09 2010-09-09 Baxter International Inc. Methods for processing substrates having an antimicrobial coating
US20100268335A1 (en) * 2009-03-27 2010-10-21 Chunlin Yang Medical devices with galvanic particulates
US20120089232A1 (en) 2009-03-27 2012-04-12 Jennifer Hagyoung Kang Choi Medical devices with galvanic particulates
US20110177146A1 (en) * 2009-07-27 2011-07-21 E. I. Du Pont De Nemours And Company Removable antimicrobial coating compositions containing cationic rheology agent and methods of use
CN104941004B (zh) 2009-11-25 2018-09-14 扩散技术公司 用抗微生物金属离子对掺杂沸石的塑料的后加载方法
CN102834122B (zh) 2009-12-11 2015-03-11 扩散技术公司 制备聚醚醚酮抗微生物植入物的方法
KR20110091461A (ko) * 2010-02-05 2011-08-11 존슨 앤드 존슨 컨수머 캄파니즈, 인코포레이티드 갈바니 미립자를 포함하는 립 조성물
CN102781406B (zh) * 2010-03-01 2015-07-08 强生消费者公司 具有理想的整体颜色的护肤组合物
EP2571542B1 (en) 2010-05-07 2018-06-20 Difusion Technologies Inc. Medical implants with increased hydrophilicity
EP2425866A1 (en) * 2010-08-04 2012-03-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Multifunctional coating with antimicrobial activity and cell adhesion regulating surface characteristics as well as a method for preparing the same
CN102398992A (zh) * 2010-09-08 2012-04-04 吉林省安能科技产业有限公司 一种复合载体固定化氨氧化细菌的方法
US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
WO2012118829A2 (en) 2011-02-28 2012-09-07 Novan, Inc. Tertiary s-nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same
WO2013036772A1 (en) 2011-09-08 2013-03-14 Corpak Medsystems, Inc. Apparatus and method used with guidance system for feeding and suctioning
US8641686B2 (en) 2012-01-20 2014-02-04 Rabie Stephan Anti-biofilm intravascular catheter
EP2874671A4 (en) * 2012-07-19 2016-01-20 Innovotech Inc ANTIMICROBIAL GEL FORMULATIONS WITH ONE SILVER (I) PERIODATE
US11766505B2 (en) 2012-07-19 2023-09-26 Innovotech, Inc. Antimicrobial silver iodate
DK2916901T3 (da) 2012-11-12 2020-08-17 Hollister Inc Intermitterende katetersamling
EP3441092B1 (en) 2012-11-14 2020-03-04 Hollister Incorporated Disposable catheter with selectively degradable inner core
US9381588B2 (en) 2013-03-08 2016-07-05 Lotus BioEFx, LLC Multi-metal particle generator and method
WO2014138885A1 (en) * 2013-03-12 2014-09-18 Innovotech Inc. Polymeric coatings having antimicrobial properties
US10046079B2 (en) 2013-03-15 2018-08-14 Materials Modification Inc. Clay composites and their applications
US9320592B2 (en) 2013-03-15 2016-04-26 Covidien Lp Coated medical devices and methods of making and using same
US9545301B2 (en) 2013-03-15 2017-01-17 Covidien Lp Coated medical devices and methods of making and using same
US10821209B2 (en) 2013-11-08 2020-11-03 Hollister Incorporated Oleophilic lubricated catheters
US9668890B2 (en) 2013-11-22 2017-06-06 Covidien Lp Anti-thrombogenic medical devices and methods
WO2015089178A1 (en) 2013-12-12 2015-06-18 Hollister Incorporated Flushable disintegration catheter
LT3079752T (lt) 2013-12-12 2020-04-27 Hollister Incorporated Praplaunamas kateteris
ES2864540T3 (es) 2013-12-12 2021-10-14 Hollister Inc Catéteres desechables por el inodoro
LT3079750T (lt) 2013-12-12 2020-07-27 Hollister Incorporated Srove nuplaunami kateteriai
US20160120174A1 (en) 2014-10-29 2016-05-05 Ronald Steven Cok Imprinted multi-layer biocidal particle structure
US9545101B2 (en) 2014-10-29 2017-01-17 Eastman Kodak Company Using imprinted multi-layer biocidal particle structure
US9416281B1 (en) 2014-10-29 2016-08-16 Eastman Kodak Company Making imprinted multi-layer biocidal particle structure
CN104371171A (zh) * 2014-11-07 2015-02-25 苏州维泰生物技术有限公司 一种医用耐高温抗静电膜及其制备方法
US9789228B2 (en) 2014-12-11 2017-10-17 Covidien Lp Antimicrobial coatings for medical devices and processes for preparing such coatings
CA2980020C (en) * 2015-03-30 2023-08-01 Giridhar Thiagarajan Application of antimicrobial agents to medical devices
CN107949403A (zh) 2015-04-16 2018-04-20 好利司泰公司 亲水性涂层及其形成方法
DK3310404T3 (da) 2015-06-17 2024-03-25 Hollister Inc Selektivt vanddesintegrerbare materialer og katetre fremstillet af sådanne materialer
US10064273B2 (en) 2015-10-20 2018-08-28 MR Label Company Antimicrobial copper sheet overlays and related methods for making and using
JP7449299B2 (ja) * 2018-10-15 2024-03-13 ケアフュージョン ３０３、インコーポレイテッド 抗菌性の無針コネクタ又はカテーテル
NL2022839B1 (en) * 2019-03-29 2020-10-06 Encapson B V An echogenic coating for ultrasound imaging of medical devices in deep tissue layers.
WO2020255079A1 (en) * 2019-06-21 2020-12-24 Bar-Ilan University Improved medical tubing and method for producing said tubing

Family Cites Families (211)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3184376A (en) 1965-05-18 Method of producing antiseptic composition
US861231A (en) 1906-05-03 1907-07-23 Johnson & Johnson Surgical ligature.
US1642089A (en) 1920-01-08 1927-09-13 Gen Zeolite Company Process and material for sterilization of liquids
US1685204A (en) 1920-10-08 1928-09-25 Gen Zeolite Company Liquid-treating material and method of making same
US1557234A (en) 1923-09-14 1925-10-13 Bechhold Heinrich Filter
US1557235A (en) 1924-07-01 1925-10-13 Becthold Heinrich Filter
US1691755A (en) 1927-07-05 1928-11-13 Henry F Buttner Dental plate and process for plating same
US2283883A (en) 1938-07-27 1942-05-19 Sacora Soc An Commercio Olii R Method of preparing oligodynamic filters
US2363354A (en) 1939-11-16 1944-11-21 Libbey Owens Ford Glass Co Method of making mirrors
US2459896A (en) 1945-01-18 1949-01-25 Schwarz George Silver impregnation
US2459897A (en) 1945-07-25 1949-01-25 Schwarz George Silver impregnation
US2421079A (en) 1946-01-31 1947-05-27 Narcus Harold Method for silvering nonconductive materials
GB646921A (en) 1947-04-24 1950-11-29 Standard Telephones Cables Ltd Metallisation of non-metallic surfaces
US2562488A (en) 1947-10-06 1951-07-31 Bactericidal Res Inc Germicidal reaction products of silver salts and monohydroxy-monoamino alkanes
US2602757A (en) 1948-04-09 1952-07-08 Morris S Kantrowitz Method and composition for producing silver coatings
US2653893A (en) 1948-08-20 1953-09-29 Isabella B Romans Methods of applying oligodynamic silver and articles produced thereby
US2689191A (en) 1948-12-10 1954-09-14 Rca Corp Formation of reflecting coatings
US2702253A (en) 1950-11-01 1955-02-15 Gasaccumulator Svenska Ab Surface metallizing method
US2758106A (en) 1951-03-06 1956-08-07 Heraeus Gmbh W C Improvements in the production of polymerisation products using redox catalysts
US2689809A (en) 1951-10-08 1954-09-21 Permachem Corp Self-sterilizing article and its preparation
US2879175A (en) 1953-10-23 1959-03-24 Ericsson Telefon Ab L M Method for producing a silver coating on a non metallic material
US2822289A (en) 1954-08-18 1958-02-04 Olin Mathieson Method of coating a surface with silver from solution
GB777679A (en) 1954-08-30 1957-06-26 Stanley Dunlop Improvements in or relating to microbicidal compositions
US2813059A (en) 1954-11-12 1957-11-12 A O Edwards Oligodynamic silver treating process and microbicidal product
US2813056A (en) 1955-03-29 1957-11-12 A O Edwards Oligodynamic silver solution and process of rendering a surface microbicidal
US3092552A (en) 1958-05-19 1963-06-04 Albert C Nolte Oligodynamic silver compositions and uses
US2947282A (en) 1958-08-06 1960-08-02 Brown Co D S Microbicidal elastomer articles
US3228881A (en) 1963-01-04 1966-01-11 Chevron Res Dispersions of discrete particles of ferromagnetic metals
US3300336A (en) 1963-09-09 1967-01-24 Scient Chemicals Inc Metal containing compositions, processes and products
US3396727A (en) 1964-01-06 1968-08-13 Nolte Albert C Jr Drainage tube for body fluids provided with filtering means coated with bacterial preventive material
US3380848A (en) 1964-05-27 1968-04-30 Polymer Res Corp Of America Method of producing solid polymeric material having bactericidal properties
US3404028A (en) 1965-12-23 1968-10-01 Agriculture Usa Process for treating a cellulosic textile fabric with an insoluble telluride to render the fabric resistant to attack by micro-organisms
GB1167285A (en) 1967-03-15 1969-10-15 Ceskoslovenska Akademie Ved Method of Preserving Hydrophilic Gels
US3561995A (en) 1967-04-03 1971-02-09 M & T Chemicals Inc Method of activating a polymer surface and resultant article
US3953545A (en) 1967-05-25 1976-04-27 Arthur Stoy Polymers containing silver and copper
US3734897A (en) 1968-05-17 1973-05-22 Ceskoslovenska Akademie Ved Polymers containing silver and copper derived from cyano and sulfonic containing monomers
US3598127A (en) 1968-06-06 1971-08-10 James G Wepsic Catheter having antibacterial substance therein provided with means permitting slow release of said substance
US3639575A (en) 1968-06-19 1972-02-01 Basf Wyandotte Corp Silver ion gel compositions and method of using the same
US3566874A (en) 1968-08-13 1971-03-02 Nat Patent Dev Corp Catheter
US3610247A (en) 1969-03-03 1971-10-05 Richard R Jackson Surface-anesthetizing medical appliance
CS148810B1 (zh) 1969-06-13 1973-05-24
US3761590A (en) 1970-05-18 1973-09-25 Research Corp Silver sulfadiazine used in the treatment of burns
US3695921A (en) 1970-09-09 1972-10-03 Nat Patent Dev Corp Method of coating a catheter
US3699956A (en) 1970-10-01 1972-10-24 Tecna Corp Percutaneous lead device
US3975350A (en) 1972-08-02 1976-08-17 Princeton Polymer Laboratories, Incorporated Hydrophilic or hydrogel carrier systems such as coatings, body implants and other articles
US3822238A (en) 1972-08-02 1974-07-02 Princeton Polymer Lab Hydrophilic polyurethane polymers
US3902500A (en) 1974-03-01 1975-09-02 Gale E Dryden Endotracheal catheter with means for positive ventilation and sterile technique
FR2330025A1 (fr) 1975-10-27 1977-05-27 Ceskoslovenska Akademie Ved Lentilles de contact en un polymere hydrophile
US4564361A (en) 1975-11-18 1986-01-14 Hiroshi Akiyama Catheter
US4054139A (en) 1975-11-20 1977-10-18 Crossley Kent B Oligodynamic catheter
US4076622A (en) 1976-06-22 1978-02-28 Rohm And Haas Company Microbiocidal macroreticular ion exchange resins, their method of preparation and use
US4197220A (en) 1976-08-27 1980-04-08 California Institute Of Technology Impregnated metal-polymeric functional beads
GB1588230A (en) 1976-09-27 1981-04-15 British Industrial Plastics Artificial resin powder coating compositions
US4156066A (en) 1977-06-23 1979-05-22 Tyndale Plains - Hunter Ltd. Polyurethane polymers characterized by lactone groups and hydroxyl groups in the polymer backbone
US4284444A (en) 1977-08-01 1981-08-18 Herculite Protective Fabrics Corporation Activated polymer materials and process for making same
US4256067A (en) 1978-04-07 1981-03-17 Honda Giken Kogyo Kabushiki Kaisha Oblong piston rings for internal combustion engine
US4327721A (en) 1978-07-07 1982-05-04 George Hanover Endotracheal tube with topical agent delivery system and method of using the same
US4255550A (en) 1978-12-22 1981-03-10 Tyndale Plains - Hunter Ltd. Polyurethane polymers characterized by carboxylate groups and hydroxyl groups in the polymer backbone
US4579731A (en) 1979-01-11 1986-04-01 Key Pharmaceuticals, Inc. Polymeric diffusion burn matrix and method of use
US4479795A (en) 1979-06-29 1984-10-30 The Procter & Gamble Company Antimicrobial polymer compositions
IT1145696B (it) 1979-08-24 1986-11-05 Rhone Poulenc Ind Procedimento di preparazione di perle magnetiche di polimeri vinilaromatici
US4252677A (en) 1979-12-04 1981-02-24 Xerox Corporation Preparation of colloidal dispersion of nickel, palladium and platinum by the polymer-catalyzed decomposition of carbonyl compounds thereof
US4252678A (en) 1979-12-04 1981-02-24 Xerox Corporation Preparation of colloidal dispersions of ruthenium, rhodium, osmium and iridium by the polymer-catalyzed decomposition of carbonyl cluster compounds thereof
JPS57500588A (zh) 1980-03-27 1982-04-08
FR2480764B1 (fr) 1980-04-18 1985-10-04 Rhone Poulenc Spec Chim Latex de polymeres magnetiques et procede de preparation
DE3026258A1 (de) 1980-07-11 1982-01-28 Gebrüder Wagschal GmbH & Co KG Feinmechanik, Feinoptik-Medizin-Technik, 2804 Lilienthal Gebrauchsgegenstand, abdeckelement zum abdecken oder umhuellen der gebrauchsgegenstaende und verfahren zu deren herstellung
US4483688A (en) 1980-09-22 1984-11-20 Hiroshi Akiyama Catheter
US4359558A (en) 1980-11-12 1982-11-16 Tyndale Plains-Hunter, Ltd. Polyurethane diacrylate compositions
US4421660A (en) 1980-12-15 1983-12-20 The Dow Chemical Company Colloidal size hydrophobic polymers particulate having discrete particles of an inorganic material dispersed therein
FR2504014A1 (fr) 1981-04-17 1982-10-22 Porges Tube endo-tracheal ou tracheotomique a ballon pour anesthesie
US4539234A (en) 1981-05-27 1985-09-03 Unitika Ltd. Urethral catheter capable of preventing urinary tract infection and process for producing the same
US4734097A (en) 1981-09-25 1988-03-29 Nippon Oil Company, Ltd. Medical material of polyvinyl alcohol and process of making
US4436855A (en) 1982-05-12 1984-03-13 The Lubrizol Corporation Two-component urethane coating system
US4443577A (en) 1982-05-12 1984-04-17 The Lubrizol Corporation One-component moisture curable urethane coating system
DE3228849C2 (de) 1982-08-02 1989-06-08 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 8000 München In den Körper einzuführendes medizinisches Gerät
US4603152A (en) 1982-11-05 1986-07-29 Baxter Travenol Laboratories, Inc. Antimicrobial compositions
DE3300203A1 (de) 1983-01-05 1984-07-05 Zinon Dr.med. 3000 Hannover Douvlis Trachealtubus mit anschluss- und fixiervorrichtungen
JPS59133235A (ja) 1983-01-21 1984-07-31 Kanebo Ltd 殺菌性ポリマー組成物及びその製造法
DE3302567A1 (de) 1983-01-26 1984-07-26 Christoph Dr. 8011 Höhenkirchen Steidle Katheter
US4540631A (en) 1983-03-28 1985-09-10 Phillips Petroleum Company Treatment of polymer using silver
US4592920A (en) 1983-05-20 1986-06-03 Baxter Travenol Laboratories, Inc. Method for the production of an antimicrobial catheter
US4563184A (en) 1983-10-17 1986-01-07 Bernard Korol Synthetic resin wound dressing and method of treatment using same
US4820292A (en) 1983-10-17 1989-04-11 Enguay Pharmaceutical Associates Anti-microbial sensitivity test and testing stratum
US4542169A (en) 1983-12-12 1985-09-17 Rohm And Haas Company Biomedical devices containing isothiazolones to control bacteria growth
US4569673A (en) 1984-01-12 1986-02-11 Battelle Development Corporation Bacterial barrier for indwelling catheters and other medical devices
JPS60232085A (ja) 1984-04-28 1985-11-18 Kanegafuchi Chem Ind Co Ltd 無菌的濾過方法
US4563485A (en) 1984-04-30 1986-01-07 The Trustees Of Columbia University In The City Of New York Injection-resistant materials and method of making same through use of nalidixic acid derivatives
US4581028A (en) 1984-04-30 1986-04-08 The Trustees Of Columbia University In The City Of New York Infection-resistant materials and method of making same through use of sulfonamides
US4725314A (en) 1984-05-07 1988-02-16 Shipley Company Inc. Catalytic metal of reduced particle size
JPS6137248A (ja) 1984-07-31 1986-02-22 テルモ株式会社 医療用器具
EP0229862A3 (en) 1986-01-24 1987-09-30 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Medical instrument
US4677143A (en) 1984-10-01 1987-06-30 Baxter Travenol Laboratories, Inc. Antimicrobial compositions
ATE88324T1 (de) 1984-12-28 1993-05-15 Johnson Matthey Plc Antimikrobielle zusammensetzungen.
US4632108A (en) 1985-02-21 1986-12-30 Sherwood Medical Company Tube and material for use in laser surgery
DE3508644A1 (de) * 1985-03-12 1986-09-18 Bayer Ag, 5090 Leverkusen Verfahren und verbindung von profilen
US4642267A (en) 1985-05-06 1987-02-10 Hydromer, Inc. Hydrophilic polymer blend
US4612337A (en) 1985-05-30 1986-09-16 The Trustees Of Columbia University In The City Of New York Method for preparing infection-resistant materials
US4886505A (en) 1985-06-07 1989-12-12 Becton, Dickinson And Company Antimicrobial surfaces and inhibition of microorganism growth thereby
US4810582A (en) 1985-11-12 1989-03-07 Tyndale Plains-Hunter Ltd. Hydrophilic polyurethane composition
US4847049A (en) 1985-12-18 1989-07-11 Vitaphore Corporation Method of forming chelated collagen having bactericidal properties
US4729914A (en) 1985-12-30 1988-03-08 Tyndale Plains-Hunter Ltd. Hydrophilic coating and substrate coated therewith
US5413788A (en) 1986-07-03 1995-05-09 Johnson Matthey Public Limited Company Antimicrobial compositions
GB8616294D0 (en) 1986-07-03 1986-08-13 Johnson Matthey Plc Antimicrobial compositions
JPS6323960A (ja) 1986-07-16 1988-02-01 Zenji Hagiwara 非晶質アルミノ珪酸塩粒子を含有する高分子体及びその製造方法
US4728323A (en) 1986-07-24 1988-03-01 Minnesota Mining And Manufacturing Company Antimicrobial wound dressings
US4810543A (en) 1986-10-17 1989-03-07 Tyndale Plains-Hunter Ltd. Articles having low friction surfaces and production thereof
US4952411A (en) 1987-02-25 1990-08-28 Trustees Of Columbia University In The City Of New York Method of inhibiting the transmission of AIDS virus
US5334588A (en) 1987-02-25 1994-08-02 The Trustees Of Columbia University In The City Of New York Composition for inhibiting transmission of hepatitis B virus
FR2613372B1 (fr) 1987-04-03 1989-06-09 Rhone Poulenc Chimie Particules composites polymere/metal compactes, dispersions aqueuses desdites particules, leur procede de preparation et leur application en biologie
JPS6415056A (en) 1987-07-09 1989-01-19 Hanarou Maeda Body indwelling tube
DE3725728A1 (de) 1987-08-04 1989-02-16 Freudenberg Carl Fa Medizinisches geraet und verfahren zu seiner herstellung
US4915694A (en) 1987-10-02 1990-04-10 Vitaphore Corporation Antimicrobial wound dressing and skin fixator for percutaneous conduits
JPH01113464A (ja) 1987-10-26 1989-05-02 Agency Of Ind Science & Technol 着色高分子重合体の製造方法
US4902503A (en) 1987-11-25 1990-02-20 Unitika Ltd. Antimicrobial latex composition
US4871790A (en) 1987-11-25 1989-10-03 Minnesota Mining And Manufacturing Company Colloidal metals in monomers or polymers
AU2800489A (en) 1987-12-02 1989-07-05 Tyndale Plains-Hunter Ltd. Hydrophilic polyurethanes of improved strength
US5344712A (en) 1990-06-29 1994-09-06 Ppg Industries, Inc. Abrasion resistant siloxane coatings containing ceria
US5201724A (en) 1987-12-23 1993-04-13 The Victoria University Of Manchester Catheter
US5019096A (en) 1988-02-11 1991-05-28 Trustees Of Columbia University In The City Of New York Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same
US4789720A (en) 1988-03-09 1988-12-06 Tyndale Plains-Hunter, Ltd. Hydrophilic polyurethanes prepared from mixed oxyalkylene glycols
US4950256A (en) 1988-04-07 1990-08-21 Luther Medical Products, Inc. Non-thrombogenic intravascular time release catheter
US4933178A (en) 1988-10-07 1990-06-12 Biointerface Technologies, Inc. Metal-based antimicrobial coating
KR900005942A (ko) 1988-10-19 1990-05-07 원본미기재 레이져 차단막
US5013306A (en) 1989-01-18 1991-05-07 Becton, Dickinson And Company Anti-infective and antithrombogenic medical articles and method for their preparation
IE64997B1 (en) 1989-01-18 1995-10-04 Becton Dickinson Co Anti-infection and antithrombogenic medical articles and method for their preparation
US5165952A (en) 1989-01-18 1992-11-24 Becton, Dickinson And Company Anti-infective and antithrombogenic medical articles and method for their preparation
US4999210A (en) 1989-01-18 1991-03-12 Becton, Dickinson And Company Anti-infective and antithrombogenic medical articles and method for their preparation
US5173531A (en) 1989-02-01 1992-12-22 Union Oil Company Of California Antistatic textile compositions and sol/gel/polymer compositions
FI95816C (fi) 1989-05-04 1996-03-25 Ad Tech Holdings Ltd Antimikrobinen esine ja menetelmä sen valmistamiseksi
US5320908A (en) 1989-05-04 1994-06-14 Ad Tech Holdings Limited Deposition of an extremely thin silver layer on a nonconducting substrate
DE3916648C1 (zh) 1989-05-22 1990-09-06 Fa. Carl Freudenberg, 6940 Weinheim, De
US5037395A (en) 1989-06-02 1991-08-06 Denco, Inc. Catheter for suppressing tunnel infection
US5061254A (en) 1989-06-21 1991-10-29 Becton, Dickinson And Company Thermoplastic elastomeric hydrophilic polyetherurethane expandable catheter
DE8915538U1 (de) 1989-07-04 1990-10-31 Drzezga, Wolfgang, Dr.med., 8000 München Endotracheal-Tubus
DE3942112A1 (de) 1989-12-20 1991-06-27 Braun Melsungen Ag Medizinische vorrichtung mit einem oligodynamisch wirkenden material
US5146916A (en) 1990-01-05 1992-09-15 Catalani Angelo S Endotracheal tube incorporating a drug-irrigation device
US5833665A (en) 1990-06-14 1998-11-10 Integra Lifesciences I, Ltd. Polyurethane-biopolymer composite
US5334691A (en) 1990-07-24 1994-08-02 Tyndale Plains-Hunter Ltd. Hydrophilic polyurethanes of improved strength
US5102401A (en) 1990-08-22 1992-04-07 Becton, Dickinson And Company Expandable catheter having hydrophobic surface
US5160790A (en) 1990-11-01 1992-11-03 C. R. Bard, Inc. Lubricious hydrogel coatings
CA2033107C (en) 1990-12-24 2001-06-12 Robert Edward Burrell Actively sterile surfaces
US5295978A (en) * 1990-12-28 1994-03-22 Union Carbide Chemicals & Plastics Technology Corporation Biocompatible hydrophilic complexes and process for preparation and use
US5061424A (en) 1991-01-22 1991-10-29 Becton, Dickinson And Company Method for applying a lubricious coating to an article
US5762638A (en) 1991-02-27 1998-06-09 Shikani; Alain H. Anti-infective and anti-inflammatory releasing systems for medical devices
US5520664A (en) 1991-03-01 1996-05-28 Spire Corporation Catheter having a long-lasting antimicrobial surface treatment
US5662913A (en) 1991-04-10 1997-09-02 Capelli; Christopher C. Antimicrobial compositions useful for medical applications
BR9205879A (pt) 1991-04-10 1994-07-05 Christopher C Capelli Composição antimicrobiana, composição adesiva, processo de tratamento de infecção em mamífero e processo para conferir proteção antimicrobiana a um paciente
DE4115390C2 (de) 1991-05-07 1998-01-29 Grose Siestrup C Dr Medizinische Vorrichtung zur Infektionsprophylaxe und Therapie durch Erzeugung eines permanent keimtötenden Silberionenflusses im Bereich von Hautdurchleitungen
US5503840A (en) 1991-08-09 1996-04-02 E. I. Du Pont De Nemours And Company Antimicrobial compositions, process for preparing the same and use
US5180585A (en) 1991-08-09 1993-01-19 E. I. Du Pont De Nemours And Company Antimicrobial compositions, process for preparing the same and use
EP0677989B1 (en) 1991-08-09 1998-09-16 E.I. Du Pont De Nemours And Company Antimicrobial compositions, process for preparing the same and use
JPH05230325A (ja) 1992-02-24 1993-09-07 Polyplastics Co 防菌、防カビ性ポリアセタール樹脂組成物
US5685961A (en) 1992-03-27 1997-11-11 P & D Medical Coatings, Inc. Method for fabrication of metallized medical devices
US5322887A (en) 1992-05-18 1994-06-21 Eastman Kodak Company Polymeric particles and a method of preparing the same
US6106853A (en) 1992-05-19 2000-08-22 Cox; James P. Processes, apparatus, and treatment agent/composition for devolatizing and stabilizing vaporous pollutants and their sources
GEP20002074B (en) 1992-05-19 2000-05-10 Westaim Tech Inc Ca Modified Material and Method for its Production
US5492763A (en) 1992-06-08 1996-02-20 Spire Corporation Infection resistant medical devices and process
US5357636A (en) 1992-06-30 1994-10-25 Dresdner Jr Karl P Flexible protective medical gloves and methods for their use
DE4226810C1 (de) 1992-08-13 1994-01-27 Theodor Dipl Ing Krall Schläuche und andere Gegenstände aus Kunststoffen für den medizinischen Bedarf, die von Keimen nicht besiedelbar sind und Verfahren zu ihrer Herstellung
US5227434A (en) 1992-08-26 1993-07-13 Olin Corporation Moisture curable polymers
US5344455A (en) 1992-10-30 1994-09-06 Medtronic, Inc. Graft polymer articles having bioactive surfaces
US5322520A (en) 1992-11-12 1994-06-21 Implemed, Inc. Iontophoretic structure for medical devices
US5848995A (en) 1993-04-09 1998-12-15 Walder; Anthony J. Anti-infective medical article and method for its preparation
US5439969A (en) 1993-04-21 1995-08-08 James A. Bolton Substrate-reactive coating composition
DE4316920A1 (de) 1993-05-20 1994-11-24 Michael Dr Med Hartmann Endotrachealer Tubus
US5567495A (en) 1993-08-06 1996-10-22 The Trustees Of Columbia University In The City Of New York Infection resistant medical devices
US5454886A (en) 1993-11-18 1995-10-03 Westaim Technologies Inc. Process of activating anti-microbial materials
US5849311A (en) 1996-10-28 1998-12-15 Biopolymerix, Inc. Contact-killing non-leaching antimicrobial materials
US5817325A (en) 1996-10-28 1998-10-06 Biopolymerix, Inc. Contact-killing antimicrobial devices
US5788687A (en) 1994-02-01 1998-08-04 Caphco, Inc Compositions and devices for controlled release of active ingredients
WO1995020878A1 (de) 1994-02-01 1995-08-10 Theodor Krall Verfahren zur herstellung von bakteriziden/fungiziden kunststoffkörpern
US5708023A (en) 1994-03-28 1998-01-13 The Trustees Of Columbia University In The City Of New York Zinc gluconate gel compositions
JPH0880597A (ja) 1994-07-14 1996-03-26 Kyodo Printing Co Ltd 抗菌性積層体、これを用いた袋体、容器および成形カップ
EP0786440B1 (en) 1994-10-14 2002-12-11 Mitsubishi Rayon Co., Ltd. Artificial marble and process for producing the same
JP3121503B2 (ja) 1994-10-18 2001-01-09 レンゴー株式会社 抗菌剤
US5916947A (en) 1994-12-02 1999-06-29 Cape Cod Research, Inc. Zinc oxide photoactive antifoulant material
JP2860951B2 (ja) 1995-01-12 1999-02-24 株式会社萩原技研 抗菌性ポリマー組成物
US5573783A (en) * 1995-02-13 1996-11-12 Nano Systems L.L.C. Redispersible nanoparticulate film matrices with protective overcoats
US5739178A (en) 1995-05-15 1998-04-14 Allergan Polymer, article and method for inhibiting the growth of ocular pathogens in eye care products
US5772640A (en) 1996-01-05 1998-06-30 The Trustees Of Columbia University Of The City Of New York Triclosan-containing medical devices
WO1997002038A1 (en) 1995-06-30 1997-01-23 Capelli Christopher C Silver-based pharmaceutical compositions
EP0760378B1 (en) 1995-09-01 1999-01-27 Shin-Etsu Chemical Co., Ltd. Polymer scale deposition preventive agent
DE69627515T2 (de) 1995-09-28 2004-02-26 Corning Inc. Material zur verleihung von nicht-klebenden und nicht-benetzenden eigenschaften
US5709672A (en) 1995-11-01 1998-01-20 Texas Tech University Health Sciences Center Silastic and polymer-based catheters with improved antimicrobial/antifungal properties
CA2243649C (en) 1996-02-15 2009-08-04 J. Paul Santerre Bioresponsive pharmacologically-active polymers and articles made therefrom
US6015816A (en) 1996-02-29 2000-01-18 The Research Foundation Of State University Of New York Antimicrobial compositions
US5736591A (en) 1996-03-01 1998-04-07 The Goodyear Tire & Rubber Co. Latex with resistance to bacterial growth
DE19640365A1 (de) 1996-09-30 1998-04-02 Basf Ag Polymer-Wasserstoffperoxid-Komplexe
US5997517A (en) 1997-01-27 1999-12-07 Sts Biopolymers, Inc. Bonding layers for medical device surface coatings
DE19715426A1 (de) 1997-04-14 1998-10-15 Bayer Ag Blockierte Isocyanatgruppen aufweisende kolloidale Metalloxide
US5928174A (en) 1997-11-14 1999-07-27 Acrymed Wound dressing device
US6605751B1 (en) 1997-11-14 2003-08-12 Acrymed Silver-containing compositions, devices and methods for making
US5965636A (en) 1998-08-04 1999-10-12 Callaway Corporation Stabilization of encapsulated colloidal metal oxides
DE19837731A1 (de) 1998-08-20 2000-02-24 Degussa Verfahren zum Beschichten der Strömungskanäle eines monolithischen Katalysatortragkörpers mit einer Beschichtungsdispersion
US6329488B1 (en) 1998-11-10 2001-12-11 C. R. Bard, Inc. Silane copolymer coatings
US6596401B1 (en) 1998-11-10 2003-07-22 C. R. Bard Inc. Silane copolymer compositions containing active agents
US6436422B1 (en) * 1998-11-23 2002-08-20 Agion Technologies L.L.C. Antibiotic hydrophilic polymer coating
US6296863B1 (en) * 1998-11-23 2001-10-02 Agion Technologies, Llc Antimicrobial fabric and medical graft of the fabric
US6399689B1 (en) 1999-03-03 2002-06-04 Lilly Industries, Inc. Abrasion resistant coatings
US6224579B1 (en) 1999-03-31 2001-05-01 The Trustees Of Columbia University In The City Of New York Triclosan and silver compound containing medical devices
US6478861B1 (en) 1999-06-25 2002-11-12 Videojet Technologies Inc. Laser markable coating
JP4272764B2 (ja) 1999-08-20 2009-06-03 キヤノン株式会社 数値制御データ作成装置、数値制御加工システム、数値制御データ作成方法及び記憶媒体
US7179849B2 (en) 1999-12-15 2007-02-20 C. R. Bard, Inc. Antimicrobial compositions containing colloids of oligodynamic metals
US6579539B2 (en) 1999-12-22 2003-06-17 C. R. Bard, Inc. Dual mode antimicrobial compositions
DE60118052T2 (de) 2000-04-13 2006-10-26 Jsr Corp. Überzugsmittel, Verfahren zur Herstellung, gehärtetes Produkt und Beschichtungsfilm
AU2001288317A1 (en) * 2000-08-30 2002-03-13 Agion Technologies, Llc Bi-laminar, hyaluronan coatings with silver-based anti-microbial properties
DK1343510T3 (da) 2000-11-29 2010-08-30 Convatec Technologies Inc Lysstabiliserede antimikrobielle materialer
FR2823113B1 (fr) 2001-04-06 2005-12-16 Oreal Composition cosmetique anti-rides a effet immediat a base de dispersion aqueuse d'au moins une charge minerale
CA2445740A1 (en) 2001-04-23 2002-10-31 Nucryst Pharmaceuticals Corp. Use of metals to treat inflammatory skin conditions
DE10128625A1 (de) 2001-06-13 2002-03-14 Ursapharm Arzneimittel Gmbh Mikrobizid beschichteter Gegenstand, Verfahren zu dessen Herstellung und dessen Verwendung
AU2007248387A1 (en) 2006-03-03 2007-11-15 C. R. Bard, Inc. Antimicrobial coating

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102170923A (zh) * 2008-09-30 2011-08-31 伊西康公司 用抗感染剂涂覆医疗器件的金属表面的方法
CN102438473A (zh) * 2009-03-11 2012-05-02 安塞尔有限公司 无粉抗微生物涂层手套
CN102695528A (zh) * 2009-08-21 2012-09-26 诺万公司 创伤敷料、其使用方法及其形成方法
US10376538B2 (en) 2009-08-21 2019-08-13 Novan, Inc. Topical gels and methods of using the same
US9919072B2 (en) 2009-08-21 2018-03-20 Novan, Inc. Wound dressings, methods of using the same and methods of forming the same
CN102695528B (zh) * 2009-08-21 2016-07-13 诺万公司 创伤敷料、其使用方法及其形成方法
US9737561B2 (en) 2009-08-21 2017-08-22 Novan, Inc. Topical gels and methods of using the same
US9526738B2 (en) 2009-08-21 2016-12-27 Novan, Inc. Topical gels and methods of using the same
US11583608B2 (en) 2009-08-21 2023-02-21 Novan, Inc. Wound dressings, methods of using the same and methods of forming the same
CN102639164A (zh) * 2009-10-28 2012-08-15 伊西康公司 具有用于医疗装置的优选微结构的抗微生物涂层
US8808724B2 (en) 2009-10-28 2014-08-19 Ethicon, Inc. Antimicrobial coatings with preferred microstructure for medical devices
CN103153353A (zh) * 2010-06-04 2013-06-12 史密斯医疗Asd公司 抗菌润滑剂
CN103554542A (zh) * 2013-11-11 2014-02-05 镇江苏惠乳胶制品有限公司 一种乳胶手套的涂层工艺
CN107205956A (zh) * 2014-10-30 2017-09-26 纺织品技术股份有限公司 输送***
CN109475661A (zh) * 2015-06-08 2019-03-15 奥特克国际公开有限公司 基于硅-聚碳酸酯二醇的聚氨酯溶液的制备方法
CN105536073A (zh) * 2015-12-22 2016-05-04 华中科技大学 一种以peo-ldpe合金为基体的含铜节育材料及其器件
CN105536073B (zh) * 2015-12-22 2018-06-12 华中科技大学 一种以peo-ldpe合金为基体的含铜节育材料及其器件
CN107441580A (zh) * 2016-05-03 2017-12-08 B·布莱恩·阿维图姆股份公司 包括抗微生物表面涂层的医疗装置以及用于控制此装置的表面上的微生物的方法
CN107441580B (zh) * 2016-05-03 2022-07-29 B·布莱恩·阿维图姆股份公司 包括抗微生物表面涂层的医疗装置以及用于控制此装置的表面上的微生物的方法
CN106075531A (zh) * 2016-06-16 2016-11-09 湖州科达化工燃料有限公司 一种消肿止痛的医用薄膜
CN106474531A (zh) * 2016-11-09 2017-03-08 泰州市榕兴医疗用品股份有限公司 一种含有抗菌剂的缝合线及制备方法
CN106880876A (zh) * 2017-02-24 2017-06-23 创领心律管理医疗器械（上海）有限公司 一种植入性医疗器械的抗菌涂层的制备方法
CN106938061B (zh) * 2017-04-17 2020-10-16 科睿驰（深圳）医疗科技发展有限公司 一种改善介入器械表面的涂层方法
CN106938061A (zh) * 2017-04-17 2017-07-11 科睿驰（深圳）医疗科技发展有限公司 一种改善介入器械表面的涂层方法
CN108066012A (zh) * 2018-01-10 2018-05-25 新乡市华康卫材有限公司 一种医疗用无菌手套
CN111909448A (zh) * 2020-07-02 2020-11-10 中国人民解放军西部战区总医院 医用材料、针刺穴位的辅助支架及其制备方法

Also Published As

Publication number Publication date
WO2003047636A3 (en) 2003-10-02
JP2005511144A (ja) 2005-04-28
WO2003047636A2 (en) 2003-06-12
US20050064176A1 (en) 2005-03-24
AU2002357050A1 (en) 2003-06-17
EP1450866A2 (en) 2004-09-01
US7820284B2 (en) 2010-10-26
AU2002357050A8 (en) 2003-06-17
EP1450866A4 (en) 2007-02-28
MXPA04005332A (es) 2005-05-16
CA2468780A1 (en) 2003-06-12

Similar Documents

Publication Publication Date Title
CN1612804A (zh) 抗微生物医用器材、抗微生物聚合物涂层及其制备方法
JP5618460B2 (ja) 細菌接着およびバイオフィルム形成の阻害のための抗微生物コーティング
US8512731B2 (en) Antimicrobial coatings for medical devices and methods for making and using them
DE60316595T2 (de) Sperrschicht für wirkstoffhaltige polymere beschichtungen
US8414547B2 (en) Modulating agents for antimicrobial coatings
US7378156B2 (en) Antimicrobial compositions containing colloids of oligodynamic metals
US10709819B2 (en) Method for coating catheters with a layer of antimicrobial agent
JP5799023B2 (ja) 迅速放出可能な抗菌剤を有する短時間使用のための医療デバイス
CN102176928A (zh) 具有可控释放的抗菌剂的医学装置
JP2002506369A (ja) 接着性の可撓性ヒドロゲル及び薬用コーティング
CN101801449A (zh) 具有无菌屏障的福利导尿管
WO2014012171A1 (en) Anti-microbial gel formulations containing a silver (i) periodate
WO1999023127A1 (fr) Polymere greffe et moulages realises a partir de celui-ci pour fournitures medicales
JP2003512094A (ja) 埋め込み物による感染を防止するためのヨウ素の電気分解的生成
Rose et al. Prevention of biofilm formation by methacrylate-based copolymer films loaded with rifampin, clarithromycin, doxycycline alone or in combination
EP2986342B1 (en) Antimicrobial catheters
EP2968686A1 (en) Polymeric coatings having antimicrobial properties
JP3541627B2 (ja) グラフトポリマーおよびそれを用いた医療用成型品
EP0607284A1 (en) Therapeutic agent in hydrophilic matrix
JP2000510713A (ja) イオン導入材料
JP2003225300A (ja) 医療用具およびその製造方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication