CN107441440A - 一种治疗儿童腹泻的药物及其制备方法 - Google Patents
一种治疗儿童腹泻的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗儿童腹泻的药物及其制备方法,属于中医中药技术领域。本发明治疗儿童腹泻的药物,由如下原料组成:茯苓、人参、葛根、砂仁、徐长卿、陈皮、山楂、薏苡仁、补骨脂、绞股蓝、甘草、三七、蜂蜜。本发明中治疗儿童腹泻的药物配方合理,可针对急性腹泻、迁延性腹泻和慢性腹泻都具有较好地治疗效果。本发明药物制备工艺简单,制备过程中对环境无污染,药物的有效成分的提取率高达97.1%~98.4%。本发明中急性腹泻有效率93.8%~96.8%,迁延性腹泻有效率97.1%~97.5%,慢性腹泻有效率96.9%~100%,总有效率96%~98%,相比较对比例增加33.3%~36.1%,治疗效果显著。
Description
技术领域
本发明属于中医中药技术领域,具体涉及一种治疗儿童腹泻的药物及其制备方法。
背景技术
腹泻,是多病原、多因素引起的以腹泻为主的一组疾病。主要特点为大便次数增多和性状改变,可伴有发热、呕吐、腹痛等症状及不同程度水、电解质、酸碱平衡紊乱。病原可由病毒(主要为人类轮状病毒及其他肠道病毒)、细菌(致病性大肠杆菌、产毒性大肠杆菌、出血性大肠杆菌、侵袭性大肠杆菌以及鼠伤寒沙门氏菌、空肠弯曲菌、耶氏菌、金葡菌等)、寄生虫、真菌等引起。肠道外感染、滥用抗生素所致的肠道菌群紊乱、过敏、喂养不当及气候因素也可致病,是2岁以下婴幼儿的常见病。通常,根据病程可将腹泻分为急性腹泻(病程<2周)、迁延性腹泻(病程2周~2月)和慢性腹泻(病程>2月)。
当前,对于儿童腹泻病多采用西医疗法,使用药物和注射液体的方法进行治疗。由于小孩爱哭闹,对于注射液体治疗不宜采用,况且在治疗过程中使用了部分抗生素,对于正在健康成长的儿童是不利的。对于药物治疗,治疗效果不显著,而且所需的时间较长。中医疗法采用内服和外敷相结合的方式,现有技术中对腹泻的治疗时间较长,一般达到了5~7天,况且中药时间较长,对于肠胃有较大的伤害,而且不能够保证足够的营养需求。经对现有技术的文献检索发现,中国专利公开号CN105126008A,公开日2015年12月9日的专利申请公开了一种治疗小儿腹泻的中药组合物及其制备方法,该发明使用口服液或颗粒剂服用,2天具有明显效果,大便次数减少,连续服用七天,儿童进食量增加,精神状态良好,但是其所需要的时间较长。
发明内容
本发明的目的在于提供一种治疗时间短,可保持药物的营养特性,能够针对不同病程的腹泻病治疗效果俱佳的治疗儿童腹泻的药物及其制备方法。
为了达到上述目的,本发明采用以下技术方案予以实现。
一种治疗儿童腹泻的药物,由如下重量份的原料组成:茯苓22~28份、人参14~30份、葛根20~26份、砂仁15~20份、徐长卿12~17份、陈皮11~17份、山楂7~10份、薏苡仁9~14份、补骨脂8~14份、绞股蓝7~12份、甘草6~11份、三七4~10份、蜂蜜4~8份。
作为优选,所述的治疗儿童腹泻的药物,由如下重量份的原料组成:茯苓25份、人参22份、葛根23份、砂仁17份、徐长卿14.5份、陈皮14份、山楂8.5份、薏苡仁11.5份、补骨脂11份、绞股蓝9.5份、甘草8份、三七7份、蜂蜜6份。
所述的治疗儿童腹泻的药物的制备方法,包括如下步骤:
1)取配方中的人参和山楂,分别对其进行水蒸气蒸馏提取,提取挥发油,得到人参挥发油提取物和山楂挥发油提取物,备用;
2)取酥油置于锅中用文火加热融化,然后将葛根和山楂一起放入其中进行翻炒,3~6min后捞出葛根和山楂,滤去酥油,然后放入到5~7倍重量份的水中浸泡28~40min后,煎煮1次,煎煮时间1.5小时,滤过后加药材重量的8~10倍重量的水煎煮三次,滤过后合并三次滤液,100目滤过,滤液加热浓缩成50℃下相对密度为1.15~1.24的稠膏ⅰ,备用;
3)取配方量的茯苓、砂仁、薏苡仁、补骨脂、三七混合粉碎,过30目筛,加7~10倍药材量体积分数为85%的乙醇中超声提取2~3次,每次15~25min,过滤,合并滤液,然后将滤液减压浓缩至原体积的1/5,得浓缩液B,保留超声提取后的药渣C;向药渣C中加入5倍量85%的乙醇回流提取4次,每次1.5h,合并提取液,得乙醇提取液,回收乙醇并浓缩,得浓缩液D;所述的超声波频率为45~50kHz,功率320W,提取温度45~48℃;
4)将配方中的徐长卿、陈皮、绞股蓝、甘草置于65℃的纯化水中,浸泡40min后煎煮,水开后保持压力在0.15~0.18MPa微沸35min,然后将上述煎煮液通过0.65um的过滤器过滤,滤液加热浓缩成50℃下相对密度为1.30的稠膏ⅱ,备用;合并浓缩液B和浓缩液D,向其中加入蜂蜜搅拌均匀,接着将人参挥发油提取物、山楂挥发油提取物、稠膏ⅰ、稠膏ⅱ加入其中混匀,再加入药学上可接受的辅料,制成颗粒剂。
根据《中国药典》以及中医药史料记载,上述配方中中药材的药理活性如下:
茯苓:甘、淡,平。归心、肺、脾、肾经。利水渗湿,健脾,宁心。用于水肿尿少,痰饮眩悸,脾虚食少,便溏泄泻,心神不安,惊悸失眠。
人参:甘、微苦,微温。归脾、肺、心、肾经。大补元气,复脉固脱,补脾益肺,生津养血,安神益智。用于体虚欲脱,肢冷脉微,脾虚食少,肺虚喘咳,津伤口渴,内热消渴,气血亏虚,久病虚羸,惊悸失眠,阳痿宫冷。
葛根:甘、辛,凉。归脾、胃、肺经。解肌退热,生津止渴,透疹,升阳止泻,通经活络,解酒毒。用于外感发热头痛,项背强痛,口渴,消渴,麻疹不透,热痢,泄泻,眩晕头痛,中风偏瘫,胸痹心痛,酒毒伤中。
砂仁:辛,温。归脾、胃、肾经。化湿开胃,温脾止泻,理气安胎。用于湿油中阻,脘痞不饥,脾胃虚寒,呕吐泄泻,妊娠恶阻,胎动不安。
徐长卿:辛,温。归肝、胃经。祛风,化湿,止痛,止痒。用于风湿痹痛,胃痛胀满,牙痛,腰痛,跌扑伤痛,风疹、湿疹。
陈皮:苦、辛,温。归肺、脾经。理气健脾,燥湿化痰。用于脘腹胀满,食少吐泻,咳嗽痰多。
山楂:酸、甘,微温。归脾、胃、肝经。消食健胃,行气散瘀,化浊降脂。用于肉食积滞,胃脘胀满,泻痢腹痛,瘀血经闭,产后瘀阻,心腹刺痛,胸痹心痛,疝气疼痛,髙脂血症。焦山楂消食导滞作用增强。用于肉食积滞,泻痢不爽。
薏苡仁:甘、淡,凉。归脾、胃、肺经。利水渗湿,健脾止泻,除痹,排脓,解毒散结。用于水肿,脚气,小便不利,脾虚泄泻,湿痹拘挛,肺痈,肠痈,赘疣,癌肿。
补骨脂:辛、苦,温。归肾、脾经。温肾助阳,纳气平喘,温脾止泻;外用消风祛斑。用于肾阳不足,阳痿遗精,遗尿尿频,腰滕冷痛,肾虛作喘,五更泄泻;外用治白癱风,斑秃。
绞股蓝:味苦;微甘;性凉。归肺;脾;肾经。益气健脾,化痰止咳,清热解毒。
甘草:甘,平。归心、肺、脾、胃经。补脾益气,淸热解毒,祛痰止咳,缓急止痛,调和诸药。用于脾胃虚弱,倦怠乏力,心悸气短,咳嗽痰多,脘腹、四肢挛急疼痛,痈肿疮毒,缓解药物毒性、烈性。
三七:甘、微苦,温。归肝、胃经。散瘀止血,消肿定痛。用于咯血,吐血,鯉血,便血,崩漏,外伤出血,胸腹刺痛,跌扑肿痛。
蜂蜜:甘,平。归肺、脾、大肠经。补中,润燥,止痛,解毒;外用生肌敛疮。用于脘腹虚痛,肺燥干咳,肠燥便秘,解乌头类药毒;外治疮疡不敛,水火烫伤。
与现有技术相比,本发明的有益技术效果:
1)本发明中治疗儿童腹泻的药物配方合理,可针对急性腹泻、迁延性腹泻和慢性腹泻都具有较好地治疗效果。本发明药物制备工艺简单,制备过程中对环境无污染,药物的有效成分的提取率高达97.1%~98.4%。
2)本发明通过对葛根和山楂用酥油翻炒后,然后再进行煎煮。一方面是为了保证药物具有较高的提取率,另一方面使得酥油中的营养成分完全渗入到药物中,保证药物具有较高的营养需求。酥油中含有丰富的营养成分,每100g酥油含有能量860千卡,蛋白质1.5g,脂肪94.4g,碳水化合物1.1g,以及含有胆固醇、维生素A、核黄素、维生素E和钙、磷、钾、钠、镁、铁、锌、硒、铜等各种大量元素和微量元素。利用本发明的处理后能够使得药物具有酥油独特的风味和滋味,有利于儿童更容易服用。
3)本发明中治疗儿童腹泻的药物具有补脾益肺、生津止渴、通经活络、化湿开胃、温脾止泻、淸热解毒、祛痰止咳、调和诸药的功效。本发明中急性腹泻有效率93.8%~96.8%,迁延性腹泻有效率97.1%~97.5%,慢性腹泻有效率96.9%~100%,总有效率96%~98%,相比较对比例增加33.3%~36.1%,治疗效果显著。
具体实施方式
下面通过具体实施例,对本发明的技术方案作进一步地具体说明。应当理解,本发明的实施例并不局限于下面的实施例,对本发明所作的任何形式上的变通和/或改变都将落入本发明的保护范围。
实施例1
一种治疗儿童腹泻的药物,由如下重量的原料组成:茯苓22g、人参14g、葛根20g、砂仁15g、徐长卿12g、陈皮11g、山楂7g、薏苡仁9g、补骨脂8g、绞股蓝7g、甘草6g、三七4g、蜂蜜4g。
所述的治疗儿童腹泻的药物的制备方法,包括如下步骤:
1)取配方中的人参和山楂,分别对其进行水蒸气蒸馏提取,提取挥发油,得到人参挥发油提取物和山楂挥发油提取物,备用;
2)取酥油置于锅中用文火加热融化,然后将葛根和山楂一起放入其中进行翻炒,3~6min后捞出葛根和山楂,滤去酥油,然后放入到5~7倍重量份的水中浸泡28~40min后,煎煮1次,煎煮时间1.5小时,滤过后加药材重量的8~10倍重量的水煎煮三次,滤过后合并三次滤液,100目滤过,滤液加热浓缩成50℃下相对密度为1.15~1.24的稠膏ⅰ,备用;
3)取配方量的茯苓、砂仁、薏苡仁、补骨脂、三七混合粉碎,过30目筛,加7~10倍药材量体积分数为85%的乙醇中超声提取2~3次,每次15~25min,过滤,合并滤液,然后将滤液减压浓缩至原体积的1/5,得浓缩液B,保留超声提取后的药渣C;向药渣C中加入5倍量85%的乙醇回流提取4次,每次1.5h,合并提取液,得乙醇提取液,回收乙醇并浓缩,得浓缩液D;所述的超声波频率为45~50kHz,功率320W,提取温度45~48℃;
4)将配方中的徐长卿、陈皮、绞股蓝、甘草置于65℃的纯化水中,浸泡40min后煎煮,水开后保持压力在0.15~0.18MPa微沸35min,然后将上述煎煮液通过0.65um的过滤器过滤,滤液加热浓缩成50℃下相对密度为1.30的稠膏ⅱ,备用;合并浓缩液B和浓缩液D,向其中加入蜂蜜搅拌均匀,接着将人参挥发油提取物、山楂挥发油提取物、稠膏ⅰ、稠膏ⅱ加入其中混匀,再加入药学上可接受的辅料,制成颗粒剂。
实施例2
一种治疗儿童腹泻的药物,由如下重量份的原料组成:茯苓25g、人参22g、葛根23g、砂仁17g、徐长卿14.5g、陈皮14g、山楂8.5g、薏苡仁11.5g、补骨脂11g、绞股蓝9.5g、甘草8g、三七7g、蜂蜜6g。
所述治疗儿童腹泻药物的制备方法同实施例1。
实施例3
一种治疗儿童腹泻的药物,由如下重量的原料组成:茯苓28g、人参30g、葛根26g、砂仁20g、徐长卿17g、陈皮17g、山楂10g、薏苡仁14g、补骨脂14g、绞股蓝12g、甘草11g、三七10g、蜂蜜8g。
所述治疗儿童腹泻药物的制备方法同实施例1。
实验例
一、病例来源:在甘肃省平凉市选择400例腹泻儿童,其中实施例1为100例,实施例2为100例,实施例3为100例,对比例100例。
二、诊断标准:治愈:大便次数、性状及症状、体征完全恢复正常,异常理化亦恢复正常;显效:大便次数明显减少(减至治疗前的1/3或以下),性状好转,症状、体征及异常理化指标明显改善;无效:不符合以上标准者。
三、治疗方法:将本发明的腹泻药物制成颗粒剂,用袋装每袋9g,急性腹泻患者每次服用1/3袋,即服用3g,迁延性腹泻患者每次服用2/3袋,即服用6g,慢性腹泻患者每次服用4/3袋,即服用12g,上述三类患者均每天服用三次。
四、治疗结果:具体治疗效果如表1所示:
由上表可知,本发明中急性腹泻有效率93.8%~96.8%,迁延性腹泻有效率97.1%~97.5%,慢性腹泻有效率96.9%~100%,总有效率96%~98%,相比较对比例增加33.3%~36.1%。
五、典型病例:
1.常某,女,5个月大,家中腹泻4天后来我院治疗。病情:日排黄色稀水样便大约5-7次,量中等,无呕吐,无脱水,无发热及咳喘,无烦躁及抽搐,小便正常,精神状态不佳。经过服用本发明的颗粒剂,每次3g,每天3次,3天后痊愈,排便正常,精神状态良好。
2.甄某,男,三个月大,患者因咳嗽1周,加重伴气促、发热4天入院。患儿1周前接触感冒家人后出现流涕、咳嗽,无鼻塞、无痰,家长予“保婴丹”口服,症状未缓解。4天前患儿咳嗽渐加重,伴气促、口周发绀、发热,热峰38.9℃,无抽搐,无呕吐、腹泻,病后来我院治疗。经过服用本发明的颗粒剂,每次6g,每天3次,3天后痊愈,无咳嗽、也不流鼻涕,精神状态良好,症状缓解。
3.狄某,女,一岁零五个月,因呕吐、腹泻伴四肢浮肿3天,精神反应差2天入院,患者于3天前无明显诱因开始出现呕吐,呕吐胃内容物10余次,无咖啡样物,伴腹泻,每天解黄色水样便10余次,伴发热,最高体温38.5摄氏度,无咳嗽、咳痰,无气促,无抽搐,无解黑便、血便。经过服用本发明的颗粒剂,每次6g,每天3次,3天后痊愈,精神状态良好。
本发明可用其他的不违背本发明的精神或主要特征的具体形式来概述。无论从哪一点来看,本发明的上述实施方案都只能认为是对本发明的说明而不能限制本发明,权利要求书指出了本发明的范围,因此,在与本发明的权利要求书相当的含义和范围内的任何改变,都应认为是包括在权利要求书范围之内。
Claims (3)
1.一种治疗儿童腹泻的药物,其特征在于由如下重量份的原料组成:茯苓22~28份、人参14~30份、葛根20~26份、砂仁15~20份、徐长卿12~17份、陈皮11~17份、山楂7~10份、薏苡仁9~14份、补骨脂8~14份、绞股蓝7~12份、甘草6~11份、三七4~10份、蜂蜜4~8份。
2.根据权利要求1所述的一种治疗儿童腹泻的药物,其特征在于由如下重量份的原料组成:茯苓25份、人参22份、葛根23份、砂仁17份、徐长卿14.5份、陈皮14份、山楂8.5份、薏苡仁11.5份、补骨脂11份、绞股蓝9.5份、甘草8份、三七7份、蜂蜜6份。
3.根据权利要求1所述的一种治疗儿童腹泻的药物的制备方法,其特征在于包括如下步骤:
1)取配方中的人参和山楂,分别对其进行水蒸气蒸馏提取,提取挥发油,得到人参挥发油提取物和山楂挥发油提取物,备用;
2)取酥油置于锅中用文火加热融化,然后将葛根和山楂一起放入其中进行翻炒,3~6min后捞出葛根和山楂,滤去酥油,然后放入到5~7倍重量份的水中浸泡28~40min后,煎煮1次,煎煮时间1.5小时,滤过后加药材重量的8~10倍重量的水煎煮三次,滤过后合并三次滤液,100目滤过,滤液加热浓缩成50℃下相对密度为1.15~1.24的稠膏ⅰ,备用;
3)取配方量的茯苓、砂仁、薏苡仁、补骨脂、三七混合粉碎,过30目筛,加7~10倍药材量体积分数为85%的乙醇中超声提取2~3次,每次15~25min,过滤,合并滤液,然后将滤液减压浓缩至原体积的1/5,得浓缩液B,保留超声提取后的药渣C;向药渣C中加入5倍量85%的乙醇回流提取4次,每次1.5h,合并提取液,得乙醇提取液,回收乙醇并浓缩,得浓缩液D;所述的超声波频率为45~50kHz,功率320W,提取温度45~48℃;
4)将配方中的徐长卿、陈皮、绞股蓝、甘草置于65℃的纯化水中,浸泡40min后煎煮,水开后保持压力在0.15~0.18MPa微沸35min,然后将上述煎煮液通过0.65um的过滤器过滤,滤液加热浓缩成50℃下相对密度为1.30的稠膏ⅱ,备用;合并浓缩液B和浓缩液D,向其中加入蜂蜜搅拌均匀,接着将人参挥发油提取物、山楂挥发油提取物、稠膏ⅰ、稠膏ⅱ加入其中混匀,再加入药学上可接受的辅料,制成颗粒剂。
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