CN107432733A - Implanted intraocular pressure monitor - Google Patents
Implanted intraocular pressure monitor Download PDFInfo
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- CN107432733A CN107432733A CN201710393827.7A CN201710393827A CN107432733A CN 107432733 A CN107432733 A CN 107432733A CN 201710393827 A CN201710393827 A CN 201710393827A CN 107432733 A CN107432733 A CN 107432733A
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- Prior art keywords
- intraocular pressure
- pressure monitor
- pressure
- seal cavity
- deformation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/16—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring intraocular pressure, e.g. tonometers
Abstract
The invention provides a kind of implanted intraocular pressure monitor, it includes:Seal cavity, its end, which has, follows the intensity of pressure to change and produce the deformation film of deformation;Supporting part, it couples with the seal cavity, and positions the direction of the deformation film of the seal cavity;Pressure sensor, it is arranged in the seal cavity, and the deformation by detecting the deformation film changes to obtain pressure signal;And signal transmitting apparatus, it is arranged in the supporting part, and the pressure signal from the pressure sensor is transferred into outside.In implanted intraocular pressure monitor involved in the present invention, can directly and precision highland measure intraocular pressure.
Description
Technical field
The present invention relates to a kind of implanted intraocular pressure monitor.
Background technology
Glaucoma is the irreversibility diseases causing blindness to rank first.The whole world there are about 60,000,000 glaucoma patients at present, wherein
8400000 blindness.Crowd's prevalence of glaucoma about 2.6% more than China, 40 years old, wherein blind rate about 30%.Glaucoma
Pathogenesis is complicated, generally believes and (sometimes referred to as " intraocular pressure ") increases relevant, the rise of pathologic intraocular pressure or fluctuation with intraocular pressure
Cause retinal ganglion cells death, optic atrophy, the gradual defect in the visual field, until total blindness.
Due to most of glaucoma patients in early stage without any symptom, patient often because defect of visual field and before go just
Examine, but visual function damage now is very serious.In developed country, the glaucoma patient for having half does not know that oneself suffers from green light
Eye;And the disease of oneself is known nothing in developing country, the glaucoma patient for having up to 90%.Chinese glaucoma patient
Treatment rate only has 10%~20%, and many patients are reached an advanced stage just to go to a doctor, add treatment difficulty and blinding it is general
Rate.Therefore, for being diagnosed as the patient of glaucoma, maximally effective chronic diseases management strategy is exactly by the treatment such as eye drops or operation
Means reduce intraocular pressure, and keep its stable, so as to slow down and control the progress of impaired vision, remain with use eyesight throughout one's life.
At present, hospital is most of measures intraocular pressure using outside intraocular pressure detector.Such measuring method includes single-point eye
Pressure measurement and tonometry in 24 hours.Spot measurement includes two kinds of planishing type and pressure-sinking type, it is necessary to which patient goes to a doctor in hospital outpatient
When measure.Wherein Goldmann tonometers, it is generally acknowledged tonometry " goldstandard ".Before patient is sitting in slit-lamp, point fiber crops
Medicine and fluorescein measure.Intraocular pressure is calculated by flattening the weight needed for cornea.Therefore measurement intraocular pressure value is thick by cornea
The influence of the physical signs such as degree, curvature, elasticity, there is some difference with true intraocular pressure value.It is generally believed that corneal thickness increases
20-30m, the higher 1mmHg of measurement intraocular pressure value.Tonometry in 24 hours, which needs to be in hospital, to be measured, per 2-4 hours once, totally 12 times, note
Intraocular fluctuation is recorded, so as to capture the intraocular pressure high level that outpatient service single-point tonometry fails to capture.Especially for intraocular pressure
The more obvious patient of fluctuation, can be with adjusting and optimizing administration time.
The content of the invention
However, above-mentioned measuring method is required for completing under the auxiliary of doctor, glaucoma patient can not be in daily life shape
Tonometry is voluntarily carried out under state, therefore the intraocular pressure data under the daily life state among going to a doctor twice can not be obtained.One
Aspect, for doctor, can not obtain in time patient's intraocular pressure data issue corresponding therapeutic scheme even therapeutic scheme it is wrong,
Therefore, also all there is visual function and is persistently damaged to some extent in the glaucoma patient in above-mentioned therapeutic modality;On the other hand,
For patients, due to lacking Dynamic intraocular pressure data as feedback and excitation, it coordinates the compliance for performing therapeutic scheme non-
It is often low, directly result in further visual field damage progress;When also resulting in next time medical, doctor can not judge that visual field damage enters
Exhibition is due to that therapeutic scheme needs to optimize and revise or patient fails effectively to perform therapeutic scheme.
The present invention is completed in view of above-mentioned present situation, its object is to, there is provided one kind is easy to continuous monitoring intraocular
The implanted intraocular pressure monitor of pressure.
Therefore, the invention provides a kind of implanted intraocular pressure monitor, it includes:A kind of implanted intraocular pressure monitor, its
Including:Seal cavity, its end, which has, follows the intensity of pressure to change and produce the deformation film of deformation;Supporting part, its with it is described close
Cavity connection is sealed, and positions the direction of the deformation film of the seal cavity;Pressure sensor, it is arranged on the sealing
In cavity, and the deformation by detecting the deformation film changes to obtain pressure signal;And signal transmitting apparatus, it is set
Outside is transferred in the supporting part, and by the pressure signal from the pressure sensor.
In implanted intraocular pressure monitor involved in the present invention, due to the deformation of the sensing intraocular pressure of intraocular pressure monitor
Film can directly contact the tissue fluid in eyes, therefore, it is possible to the pressure of direct measurement intraocular.Accordingly, with respect to conventional outside
Detection of eyeball tension device for measuring the mode of intraocular pressure, implanted intraocular pressure monitor of the invention, can more precisely measure eye
Interior pressure.
In addition, in implanted intraocular pressure monitor involved in the present invention, alternatively, in addition to process circuit, the place
Pressure sensor described in circuit drives is managed, and the pressure signal to being obtained by the pressure sensor is handled.Thus, energy
The pressure signal that noise is inhibited enough is obtained, so as to improve the measurement accuracy of intraocular pressure.
In addition, in implanted intraocular pressure monitor involved in the present invention, alternatively, the signal transmitting apparatus receive from
The energy of outside input, and the energy is supplied to pressure sensor via the process circuit.Further optionally, institute
Energy of the signal transmitting apparatus reception from outside input is stated, and is supplied to pressure to pass via the process circuit energy
Sensor., can be from external reception energy by signal transmitting apparatus, while pressure signal effectively can be transferred to outside.
In addition, the signal transmitting apparatus can be coil.In this case, can be via wirelessly progress energy and data
Transmission.
In addition, in implanted intraocular pressure monitor involved in the present invention, alternatively, the pressure sensor is to carry light
The pressure sensor of grid, and the pressure sensor includes laser and photodetector, and the photodetector passes through spy
The stripe order recognition of the light for being sent by the laser and being interfered by the grating is surveyed to obtain the deformation of the deformation film
Change, to calculate the pressure signal.In this case, deformation film is obtained by identifying the change of interference striations
Deformation variable quantity, thereby, it is possible to accurately measure the deformation variable quantity of deformation film, so as to obtain more accurate pressure letter
Number.
In addition, in implanted intraocular pressure monitor involved in the present invention, alternatively, the pressure sensor and the shape
Become intermembranous formation internal cavity.
In addition, in implanted intraocular pressure monitor involved in the present invention, alternatively, the internal cavity is by extending to
The pipeline of the supporting part connects with extraneous air.In this case, internal cavity and external air pressure can be ensured
Keep in balance, drifted about thus, it is possible to pressure signal when suppressing measurement intraocular pressure.
In addition, in implanted intraocular pressure monitor involved in the present invention, alternatively, the seal cavity is cylindrical.
In this case, seal cavity can be more easily manufactured
In addition, in implanted intraocular pressure monitor involved in the present invention, alternatively, the supporting part includes setting
The jut stated the base portion of signal transmitting apparatus and stretched out from the base portion, the jut are fixed with the seal cavity
Connection.
In addition, in implanted intraocular pressure monitor involved in the present invention, alternatively, the base portion is in the form of annular discs.
In addition, in implanted intraocular pressure monitor involved in the present invention, alternatively, the supporting part, which is additionally provided with, to be used for
The mounting hole of surgical instrument operation.
In addition, in implanted intraocular pressure monitor involved in the present invention, alternatively, the distal cannula and the near-end
Part couples via outer tube.Thereby, it is possible to realize distal cannula with proximal part by outer tube to couple.
In accordance with the invention it is possible to direct and precision highland measures the pressure of intraocular.
Brief description of the drawings
Fig. 1 is the three-dimensional structure diagram for showing the implanted intraocular pressure monitor involved by embodiments of the present invention.
Fig. 2 is to show another three-dimensional structure diagram of implanted intraocular pressure monitor involved by embodiments of the present invention.
Fig. 3 is the implantation position for showing the implanted intraocular pressure monitor involved by embodiments of the present invention in eyes
Schematic diagram.
Fig. 4 is the seal cavity and supporting part for showing the implanted intraocular pressure monitor involved by embodiments of the present invention
The structure chart of separation.
Fig. 5 is the internal structure schematic diagram for showing the implanted intraocular pressure monitor shown in Fig. 1.
Fig. 6 is the schematic diagram of the coil of the implanted intraocular pressure monitor involved by embodiments of the present invention.
Fig. 7 is to show showing for pressure sensor in the implanted intraocular pressure monitor involved by embodiments of the present invention
It is intended to.
Symbol description:
1 ... implanted intraocular pressure monitor, 2 ... eyes, 10 ... seal cavities, 12 ... cavity walls, 14 ... deformation films, 16 ...
Feed through structures 20 ... supporting part, 22 ... base portions, 100 ... pressure sensors, 200 ... process circuits, 16 ... feed-through holes, 300 ... lines
Circle.
Embodiment
Hereinafter, refer to the attached drawing, the preferred embodiment of the present invention is explained.In the following description, for identical
Part assign identical symbol, the repetitive description thereof will be omitted.Scheme in addition, accompanying drawing is simply schematical, the mutual chi of part
Very little ratio or the shape of part etc. can be with the differences of reality.
Fig. 1 is the three-dimensional structure diagram for showing the implanted intraocular pressure monitor involved by embodiments of the present invention.Fig. 2 is
Show another three-dimensional structure diagram of implanted intraocular pressure monitor involved by embodiments of the present invention.Fig. 3 is to show this hair
The schematic diagram of implanted intraocular pressure monitor involved by bright embodiment in the implantation position of eyes.
As depicted in figs. 1 and 2, implanted intraocular pressure monitor 1 involved in the present invention (also referred to as " intraocular pressure monitor 1 ") can be with
Substantially it is in " T " character form structure.Intraocular pressure monitor 1 includes seal cavity 10 and the supporting part 20 coupled with seal cavity 10.In addition,
Although being in " T " character form structure this embodiment illustrates intraocular pressure monitor 1, present embodiment is not particularly limited intraocular pressure
The shape of monitor 1, such as can also be other shapes structure, such as cylinder, parabolical, pylon shape etc..
In the present embodiment, gas can be filled with seal cavity 10, such as is filled with the indifferent gas such as nitrogen, argon gas
Body.In addition, in the case where intraocular pressure monitor 1 is in " T " character form structure, the supporting part 20 coupled with seal cavity 10 (is specifically
The outer region of supporting part 20) outer surface of eyeball can be fitted in.
Intraocular pressure monitor 1 involved in the present invention can be implanted in many positions of eyes so as to direct measurement intraocular
The intensity of pressure.Implantable position for example including in cornea, anterior chamber, back room, vitreum, sheaf space, upper strata train of thought on retina
Film, suprachoroidal space, secondary conjunctiva, sclera are outer, in sclera, eye circumference, trabeculectomy position, trabeculectomy position, or
Cyclodialysis space etc..
In the present embodiment, intraocular pressure monitor 1 can be implanted in the anterior chamber of eyes, and make the deformation of seal cavity 10
Eye inner tissue liquid of the film contact positioned at anterior chamber.As an example, Fig. 3 shows the anterior chamber 2a that intraocular pressure monitor 1 is implanted to eyes 2
Situation.In this example, by the way that intraocular pressure monitor 1 to be implanted in the anterior chamber of eyes, so as to which intraocular pressure monitor 1 can be surveyed directly
Measure the intensity of pressure of intraocular.
In some instances, can battery (minicell) be set in intraocular pressure monitor 1 to be supplied to intraocular pressure monitor 1
Electricity.In addition, in other examples, can also be powered by the external equipment coupled with intraocular pressure monitor 1, such as external electricity
Source passes to intraocular pressure monitor 1 by way of being wirelessly transferred.
In some instances, intraocular pressure can be performed as often as measuring by intraocular pressure monitor 1.It is, for example, possible to use
The hand-held reader (not shown) coupled with intraocular pressure monitor 1 measures.As an example, the hand-held reader can be with
The receiving coil (not shown) for the pressure signal that part and reception with emitted energy emit from intraocular pressure monitor 1.
By the hand-held reader, it can both be powered to intraocular pressure monitor 1, the pressure measured by intraocular pressure monitor 1 can also be received
Signal.
In the present embodiment, the measurement of intraocular pressure can monitor (discontinuous monitoring) in a manner of interruption, can also
Monitored (continuous monitoring) in a manner of continuous (such as enough frequency).Intraocular pressure monitor 1 is read by hand-held reader
Pressure data, it may be determined that daily Diurnal IOP curve, so as to detect peak intraocular pressure and pressure peak.Hand-held is read can be automatic
Ground by the patient's intraocular pressure information transmission obtained to the doctor in charge, so as to help the intraocular pressure situation of doctor remote monitor patient.
The direct tonometry data obtained by intraocular pressure monitor 1 have many benefits.For example, tonometry data can
To trigger alarm to patient, and transmit this data to long-range server or the office of the patient doctor in charge.In addition, hair
Being sent to the data of remote server can be analyzed, such as carry out data mining to determine statistical trend and analysis.By
This, by these data, doctor can be to monitor patient's state of an illness, to allow patient to obtain timely and effectively control in time
Treat.
Referring again to Fig. 3, eyes include sclera and crystalline lens, and crystalline lens makes light refraction and the retina in eyes is formed
Image.Retina includes cone cell and rod cell, can detect light color susceptibility and high visual sensitivity.Retina is also
Including blind spot, optic nerve collects and is connected to brain herein.Iris is located above crystalline lens, its in the dark in response to light and
Expansion is but shunk in bright light, and the light intensity being so mapped on retina can strengthen and weaken respectively.Before eyes include
Portion and rear portion, crystalline lens are just arranged between.Front portion includes aqueous humor, and rear portion includes vitreum.The rear chamber of eyes prolongs
Stretch between iris and lenticular preceding coating, and including aqueous humor.Front portion includes the back room.The liquid of eyes is generally from back room
Anterior chamber is discharged into, and is discharged to outside schlemm's canal to keep intraocular pressure.
The measurement end (end for including deformation film) of intraocular pressure monitor 1 can be implanted to the anterior chamber of eyes, supervise intraocular pressure
The front end for surveying device 1 directly contacts with the tissue fluid in eyes, so as to which intraocular pressure monitor 1 is capable of the intraocular pressure of direct measurement eyes
Power.
In the present embodiment, the size of intraocular pressure monitor 1 is not particularly limited, such as the length of intraocular pressure monitor 1 can
Up to 2~15mm.In addition, from the viewpoint of the current operation safety, the width of its widest part is about 5mm, in this case, can
Reduce postoperative complication.
Fig. 4 is the seal cavity and supporting part for showing the implanted intraocular pressure monitor involved by embodiments of the present invention
The structure chart of separation.Fig. 5 is the internal structure schematic diagram for showing the implanted intraocular pressure monitor shown in Fig. 1.
In the present embodiment, the intensity of pressure is followed to change and produce as shown in figure 4, the end of seal cavity 10 can have
The deformation film 14 of raw deformation.In some instances, the end of seal cavity 10 can be front end, i.e. be contacted with eye inner tissue liquid
One end.
In addition, in some instances, deformation film 14 can be elastic membrane.After intraocular pressure monitor 1 is implanted to assigned position,
Deformation film 14 positioned at the front end of seal cavity 10 will directly contact with the tissue fluid of inside ofeye, because deformation film 14 can follow
Intraocular pressure Strength Changes and produce deformation, therefore, by deformation film 14, the intensity of pressure of eye inner tissue's liquid can be obtained.
In the present embodiment, seal cavity 10 can be in substantially cylindric.In addition, seal cavity 10 can be by side wall
12nd, deformation film 14 and feed through structures 16 are formed.In addition, although present embodiment shows seal cavity 10 to be substantially cylindric,
But seal cavity 10 can also be other shapes, such as cuboid or irregular shape etc..
In the present embodiment, side wall 12 can be shaped generally as cyclic structure.Thickness (the i.e. thickness of ring wall of side wall 12
Degree) it is not particularly limited, such as in some instances, the ring wall thickness of side wall 12 is about that more than 0.3mm just can reach good
Support strength, for example, the ring wall thickness of side wall 12 is preferably 0.3mm~1mm.
In addition, in the present embodiment, deformation film 14 can be arranged on the end of side wall 12, feed through structures 16 are arranged on side
The other end of wall 12.In addition, for example deformation film 14, side wall 12 and feed through structures 16 can be welded on one by way of welding
Rise.Here, the mode of welding can be used well known to a person skilled in the art technology such as laser welding, therefore, in this explanation
It will not be described in great detail in book.
In the present embodiment, side wall 12 can be by selected from titanium and its alloy, noble metal (including gold, silver and platinum group metal
(ruthenium, rhodium, palladium, osmium, iridium, platinum)) and its alloy, medical grade (biograde) stainless steel, tantalum, niobium, Nitinol (Nitinol) or
At least one of nickel cobalt chrome molybdenum (MP35N) is formed.In addition, side wall 12 preferably can be by titanium or titanium alloy material structure
Into.
With reference to figure 5, feed through structures 16 can be by ceramic bases 16c and the metal for being filled in feed-through hole 16a and feed-through hole 16b
Post is formed.In such a case, it is possible to realize ceramic bases 16c both sides via the gold for being filled in feed-through hole 16a and feed-through hole 16b
Belong to post and it is conductive.
In addition, for the ease of the electrical connection with process circuit 200 (being described later on), can also be enterprising in ceramic bases 16c
Row metal patterns.Can include the metal pattern on ceramic bases 16c the step of metal deposit (deposition) or
The Conventional process steps such as (sputtering), photoetching (lithography), etching (etching) are sputtered, due to these conventional works
Skill step belongs to known technology, therefore repeats no more here.In addition, the metal pattern in ceramic bases 11 can also be adopted
With known silk-screen printing technique.
As shown in figure 4, it is filled with metal column in feed-through hole 16a, 16b.The shape of metal column can respectively with feed-through hole
16a, 16b coordinate.By setting feed through structures 16, so as to ensure the high-air-tightness of seal cavity 10, and can enough ensures
The conduction of the both sides of feed through structures 16.
In addition, in seal cavity 10, pressure sensor 100 and process circuit 200 are provided with.Because seal cavity 10 needs
To be retained in for a long time in eyes as implant, therefore the side wall 12 of seal cavity 10, deformation film 14 and feed through structures 16 are each
Part needs directly to contact with the tissue fluid in eyes, faces internal complex physiologic environment.Therefore, the biology of seal cavity 10
Security, it is chronically implanted requirement such as ISO 10993 (international standard), GB/T 16886 that the needs such as reliability meet correlation
(Chinese Industrial Standards (CIS)) etc..
In general, in order to ensure the biological safety of intraocular pressure monitor 1, it is chronically implanted reliability etc., seal cavity 10
On the one hand by the abiotic security component in intraocular pressure monitor 1 such as IC chip, printed circuit board (PCB) (PCB) with being implanted portion
Position (such as tissue fluid) isolation;On the other hand, drawn and believed from the seal cavity 10 by feed-through hole 16a, 16b of feed through structures 16
Number interactive function wire.That is, the circuit of seal cavity 10 is drawn out to signal via feed-through hole 16a, 16b of feed through structures 16
Transmitting device (being coil 300 here) (referring to Fig. 6).
As shown in Figure 3 and Figure 4, supporting part 20 couples with seal cavity 10.Supporting part 20 can include base portion 22 and from base
The jut 24 that portion 22 is stretched out.In addition, base portion 22 for example can be with the form of annular discs, jut 24 is in generally a cylindrical shape.In addition, projection
Portion 24 can be in raised 24a, the 24b of relative both sides along implantation direction arrangement (with reference to figure 4).In this case, due to
Raised 24a and raised 24b are provided with the both sides of jut 24, therefore can be easier to make the otch of eyeball surface (sclera is cut
Mouthful) such as watertight naturally, the suture for the mouth that is thus more beneficial for performing the operation.
In addition, signal transmitting apparatus can be provided with base portion 22.In the present embodiment, signal transmitting apparatus can be
Coil 300 (referring to Fig. 5).Coil 300 can be via feed through structures 16 (being specifically via feed-through hole 16a, 16b) and process circuit
200 connections.
In addition, Fig. 6 is the schematic diagram of the coil 300 of the implanted intraocular pressure monitor involved by embodiments of the present invention.
As shown in fig. 6, coil 300 can receive the energy from outside input as reception antenna, can also be monitored from intraocular pressure is arranged on
Battery (not shown) inside device 1 obtains energy.Coil 300 is as transmitting antenna by the pressure from pressure sensor 100
Signal is transferred to outside.In other words, the pressure signal from pressure sensor 100 is via (the specifically annular seal space of seal cavity 10
The feed through structures 16 of body) and it is transferred to the coil 300 of supporting part 20.Here, feed-through hole 16a, 16b and coil of feed through structures 16
Connecting line 420,440 electrically connect.By coil 300, effectively the pressure signal of intraocular can be transferred to outside eye, simultaneously will
Energy outside eye is transferred to the intraocular pressure monitor 1 of intraocular, the monitoring thus, it is possible to realize convenient intraocular pressure.
In the present embodiment, pressure sensor 100 can be couple to outside reading via process circuit 200, coil 300
Take device (not shown).Here, external reader can determine disease according to the intraocular pressure and outside atmospheric pressure directly measured
The intraocular pressure of people.Because atmospheric pressure can fluctuated about in the range of ± 10mmHg, and can also with the height above sea level of patient and
Become, thus according to the atmospheric pressure outside the intraocular pressure and eyes obtained by intraocular pressure monitor 1 determine to be obtained final
Intraocular pressure, thus, it is possible to significantly improve report to doctor and the accuracy of the intraocular pressure of patient.
External reader for example can determine the intraocular pressure of patient according to the intraocular pressure and atmospheric pressure directly measured.For example,
External reader can include barometric pressure sensor, so as to the intraocular pressure and the locality that are directly measured according to pressure sensor 100
Atmospheric pressure determines to report intraocular pressure to doctor and patient.Alternatively, external reader can also include determining that patient is geographical
The special circuit of position, and patient present position can be determined using patient location information according to the Weather information of meteorology
Pressure.The geographical position coordinates of patient can be by mobile phone or global positioning system (GPS) electricity with external reader
Road is positioned.
It is well known that atmospheric pressure can slowly fluctuate with Changes in weather, and about in ± 10mmHg magnitude.
In this case, can in data processing stage according to weather information come the correction made to the patient's intraocular pressure measured, there is provided essence
Really higher intraocular pressure value.In addition, the position by determining patient, can be with the determination atmospheric pressure related to height above sea level where patient
Fluctuation, and for determining the intraocular pressure of patient.For example, the big of patient position and height above sea level is subtracted from the intraocular pressure directly measured
Atmospheric pressure, to determine the intraocular pressure corrected of the report to doctor and patient, it thus can determine that intraocular pressure of the report to doctor and patient.
Fig. 7 is to show showing for pressure sensor in the implanted intraocular pressure monitor involved by embodiments of the present invention
It is intended to.Pressure sensor 100 is arranged in seal cavity 10 and close to deformation film, and pressure sensor 100 is by detecting deformation
The deformation of film changes to obtain pressure signal.Internal cavity 16 is formed between pressure sensor 100 and deformation film 14.
In the present embodiment, pressure sensor 100 can use the pressure sensor with grating.Specifically, press
Force snesor 100 includes substrate 110, grating 120 and the laser 150 and light being arranged between substrate 110 and grating 120
Electric explorer 130.Laser 150 projects laser L at an angle relative to substrate 110.Grating 120 is translucent grating
Structure, its material are not particularly limited.Thus, some is passed through grating 120 by the laser for inciding grating 120, there is one
Shunt excitation light is reflected by grating 120.
As shown in fig. 7, in some instances, the laser L launched by laser 150 advances in the direction along shown by arrow.
Diffraction occurs after running into grating 120 by laser L and transmission, some laser L are reflected by grating 120, and some laser L is direct
Through grating 120.And captured by reflection by photodetector 130.It is distorted film 14 through the laser of grating 120 and reflects
Return.The laser of this two parts reflection will interfere, and the light distribution of interference light is detected by photodetector 130.Due to
Deformation film 14 can follow intraocular pressure Strength Changes and produce deformation, therefore, in above-mentioned optical diffraction and interventional procedures, two
The interference fringe that shunt excitation light is formed will change.Because different interference fringes corresponds to different light distribution, photodetection
The light intensity that device 130 is detected is also different.Thus, by analyzing the relation of intraocular pressure and luminous intensity, thus, it is possible to obtain intraocular pressure
The intensity of pressure.
In the present embodiment, the energy of laser 150 can be provided by the battery being arranged in intraocular pressure monitor 1,
Energy can be obtained from outside by coil 300.Laser 150 can use such as Vcsel.It is this
Laser can launch the laser perpendicular to the surface of laser, therefore, use Vcsel, Neng Gourong
Change places and control the injection direction of laser.Here, photodetector 130 can be set multiple, such as two.
In the present embodiment, jut 24 can be fixedly connected (referring to Fig. 5) with seal cavity 10.In addition, by prominent
Portion 24 is played, the direction of the deformation film 14 of location sealing cavity 10 can be facilitated.
In addition, in the present embodiment, process circuit 200 can be with driving pressure sensor 100, and to by pressure sensing
The pressure signal that device 100 obtains is handled.Process circuit 200 can include example by being made on printed circuit board (PCB) (PCB)
Such as resistor, capacitor or inductor discrete component or IC chip (IC) such as application specific integrated circuit
(ASIC), PLD (FPGA), electricallyerasable ROM (EEROM) (EEPROM) etc. and form.In addition, process circuit
200 can also be other functional parts, as long as disclosure satisfy that specific implantation with desired function.In addition, process circuit
200 can be formed by PCB layer is folded.Thus, it is possible to effectively reduce the occupied area of process circuit 200.
In the present embodiment, process circuit 200 is such as can play to input signal, stimulus signal or detection signal
Various signals carry out the effect of signal transacting.
In addition, in order to improve the measurement accuracy of intraocular pressure monitor 1, internal cavity 16 can also be made by extending to supporting part
20 pipeline (not shown) connects with extraneous air.Because internal cavity 16 is connected by pipeline with extraneous air, therefore, it is possible to
Reduce measurement error caused by external air pressure changes, improve the measurement accuracy of intraocular pressure monitor 1.
Pressure sensor 100 involved by present embodiment can be made by the method for MEMS (MEMS)
Make.For example, pressure sensor 100 can include the monolithic sensor supported with substrate (such as substrate of glass).Alternatively, pressure
Sensor 100 can also include mixed type sensor, and it has the flexible substrates for being supported on such as flexible printed circuit board (PCB)
On pressure sensor for micro electro-mechanical system, e.g. polyimide flex printed circuit board (PCB).
The method that intraocular pressure monitor 1 is implanted into glasses is not particularly limited.For example, packaged intraocular pressure can be monitored
Device 1 is placed into sleeve pipe, and intraocular pressure monitor 1 is sent into implant site such as anterior chamber close to applying tired Mu Shi by means of delivery
The position of pipe.
In some instances, in supporting part 20, it is additionally provided with the mounting hole 22a for surgical instrument operation.It is for example, logical
It is chimeric with mounting hole 22a to cross the means of delivery of ophthalmologic operation, so as to intraocular pressure monitor 1 is implanted into by means of delivery
To predetermined portion such as anterior chamber.Means of delivery size is suitable to receive intraocular pressure monitor 1.
Although being illustrated above in association with drawings and embodiments to the present invention, it is not intended to limit
The present invention, it will be appreciated that to those skilled in the art, without departing from the spirit and scope of the present invention, can
To be deformed and be changed to the present invention, these deformations and change are each fallen within the scope of the claimed protection of the present invention.
Claims (10)
- A kind of 1. implanted intraocular pressure monitor, it is characterised in that:Including:Seal cavity, its end, which has, follows the intensity of pressure to change and produce the deformation film of deformation;Supporting part, it couples with the seal cavity, and positions the direction of the deformation film of the seal cavity;Pressure sensor, it is arranged in the seal cavity, and the deformation by detecting the deformation film changes to obtain Pressure signal;AndSignal transmitting apparatus, it is arranged in the supporting part, and by the pressure signal from the pressure sensor It is transferred to outside.
- 2. implanted intraocular pressure monitor as claimed in claim 1, it is characterised in that:Also including process circuit, the process circuit drives the pressure sensor, and to being obtained by the pressure sensor Pressure signal handled.
- 3. implanted intraocular pressure monitor as claimed in claim 2, it is characterised in that:The signal transmitting apparatus receives the energy from outside input, and the energy is supplied to via the process circuit Pressure sensor.
- 4. the implanted intraocular pressure monitor as described in any one of claims 1 to 3, it is characterised in that:The pressure sensor is the pressure sensor with grating, andThe pressure sensor includes laser and photodetector, and the photodetector is sent out by detecting by the laser The stripe order recognition for the light for going out and being interfered by the grating changes to obtain the deformation of the deformation film, described to calculate Pressure signal.
- 5. implanted intraocular pressure monitor as claimed in claim 4, it is characterised in that:Internal cavity is formed between the pressure sensor and the deformation film.
- 6. implanted intraocular pressure monitor as claimed in claim 5, it is characterised in that:The internal cavity is connected by extending to the pipeline of the supporting part with extraneous air.
- 7. the implanted intraocular pressure monitor as described in any one of claims 1 to 3, it is characterised in that:The seal cavity is cylindrical.
- 8. the implanted intraocular pressure monitor as described in any one of claims 1 to 3, it is characterised in that:The supporting part includes the base portion for being provided with the signal transmitting apparatus and the jut stretched out from the base portion,The jut is fixedly connected with the seal cavity.
- 9. implanted intraocular pressure monitor as claimed in claim 1, it is characterised in that:The base portion is in the form of annular discs.
- 10. implanted intraocular pressure monitor as claimed in claim 1, it is characterised in that:The supporting part is additionally provided with the mounting hole for surgical instrument operation.
Priority Applications (2)
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CN114569063A (en) * | 2022-04-24 | 2022-06-03 | 明澈生物科技(苏州)有限公司 | Intraocular pressure sensor |
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CN109157189A (en) | 2019-01-08 |
CN109157190B (en) | 2019-10-01 |
CN107432733B (en) | 2019-08-20 |
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