CN107362079A - A kind of whitening moisturizing face masque with antibacterial acne-removing and preparation method thereof - Google Patents
A kind of whitening moisturizing face masque with antibacterial acne-removing and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to daily chemical product technical field, and in particular to a kind of whitening moisturizing face masque with antibacterial acne-removing and preparation method thereof.Whitening moisturizing face masque provided by the invention with antibacterial acne-removing includes following components：P-Cymene, pneumatically conveying, anti-sensitizer, ceramide, squalene, hyaluronic acid, fucoidin, allantoin, niacinamide, glutathione, emulsifying agent, preservative and water.The present invention not only has good whitening, moistening effect and antibacterial anti-acne effect good, can effectively solve due to the excessive breed bacteria of facial mask nutritional ingredient and excessively carbuncled worry, small pox also have blood easily to infect to obtain problem to fat secretion after racking on the face for hebetic young boys and girls.
Description
Technical field
The invention belongs to daily chemical product technical field, and in particular to a kind of whitening moisturizing face masque with antibacterial acne-removing
And preparation method thereof.
Background technology
With advancing age, plus dry natural environment, water-deficient area particularly is dried in western part, skin of face
Moisture and nutrition can all be lost in, and be casted off a skin sometimes because of water shortage, or working clan occurs in face of the radiation of computer, printer etc., skin
It is wrinkle, dark yellow, loose, in terms of skin existing age it is mutually more far short of what is expected than actual age year, the image to people is brought very big tired
Disturb, the people for then paying attention to skin nursing both knows about the importance of face mask film.
Chinese patent application CN102743309A discloses a kind of moisture saver mask, and it is with deionized water, D-sorbite, water
It is one kind prepared by raw material to solve collagen, vitamin E, potassium alginate, hyaluronic acid, double imidazolidinyl urea and mulberry root extract
Some shortcomings and deficiencies part be present in facial mask, the patent of the disclosure：Double imidazolidinyl urea is that one kind is mainly used in cosmetics
Preservative, it is to reach corrosion-resistant purpose by slow release formaldehyde, its general addition no more than 0.3%, and
The addition of the displosure formula is 1-2%, thus prepared product to human body be exist it is potentially hazardous；Used hydrolysis
The molecular weight of collagen does not explain, and product efficacy prepared by disclosed method does not explain.
Chinese patent CN103599037B, which discloses a kind of green plum shrink facial mask shrink facial mask, includes honey ultrafine powder, palm fibre
Palmitic acid isopropyl propionate, glycerine, triethanolamine and green plum impregnation solution, green plum moisture lock mask of the present invention, there is unique moisturizing
Water lock function, the needs of skin water shortage can be met very well, moisture and substantial amounts of nutriment for skin supplement missing, effectively
Regulation skin water and oil balance, the purpose that can both reach oil-control effectively moisturizing and can also pin moisture.
Due to the existing excessive breed bacteria of facial mask nutritional ingredient, for hebetic young boys and girls, fat secretion is excessive on the face
Carbuncled worry, small pox also have blood easily to infect after racking, using the antibacterial effect of anti-inflammatory is not reached after common facial mask, therefore
Need to provide a kind of new technical scheme to solve the above problems.
The content of the invention
To solve problems of the prior art, the present invention provides a kind of skin whitening, moisturizing face with antibacterial acne-removing
Film and preparation method thereof.
A kind of whitening moisturizing face masque with antibacterial acne-removing of the present invention, including following components and its parts by weight：
P-Cymene 0.2-0.4 parts, pneumatically conveying 1-3 parts, anti-sensitizer 0.1-0.5 parts, -3 parts of Cer EOS,
Squalene 0.5-2.5 parts, hyaluronic acid 0.1-0.5 parts, fucoidin 0.5-3 parts, allantoin 0.5-1.5 parts, niacinamide 2-4
Part, glutathione 0.01-0.05 parts, emulsifying agent 1-3 parts, preservative 0.2-0.4 parts and water 65-85 parts.
Preferably, the described whitening moisturizing face masque with antibacterial acne-removing, by following components and its parts by weight array
Into：
0.3 part of P-Cymene, 2 parts of pneumatically conveying, 0.3 part of anti-sensitizer, Cer NS part, 1.5 parts of squalene,
0.3 part of hyaluronic acid, 2 parts of fucoidin, 1 part of allantoin, 3 parts of niacinamide, 0.03 part of glutathione, 2 parts of emulsifying agent, preservative
0.3 part and 75 parts of water.
Preferably, the preparation method of described pneumatically conveying comprises the following steps：
(1) 25.64g palmitic acids and thionyl chloride 23.79g are added into magnetic agitation reactor, then adds 0.5g five
Methyl diethylenetriamine, is heated to 60 DEG C of stirring reaction 2h, and reaction pours into the reactant in magnetic agitation reactor after terminating
Thionyl chloride is evaporated off in 70 DEG C of rotations of distiller, produces palmitoyl chloride；
(2) take 100ml three-necked flasks to add 15g kojic acids, be 5 with 60ml acetone and pyridine volume ratio:1 solution dissolving,
The palmitoyl chloride that 10g steps S1 is obtained is instilled in three-necked flask, is filtered, is dried after being washed at room temperature after reaction 2h with cooling water
Produce.
Preferably, described anti-sensitizer is purslane flavones.
Preferably, the extracting method of described purslane flavones is：Purslane 300g is weighed, 60 DEG C of dries pulverizings cross 80 mesh
It is placed in after sieve in 500ml conical flasks, with 80 DEG C of backflow 3h of 300ml petroleum ethers, obtains filtrate I and filter residue；300ml is used after filter residue drying
85 DEG C of backflow 2h of ethanol, obtain filtrate II；Merging filtrate I and II, it is concentrated and dried, produces.
Preferably, described emulsifying agent is glycerin monostearate.
Preferably, described preservative is by Phenoxyethanol and Sensiva SC50 in mass ratio 4:1 composition.
In addition, present invention also offers a kind of preparation method of the whitening moisturizing face masque with antibacterial acne-removing, including
Following steps：
S1, P-Cymene, pneumatically conveying, anti-sensitizer, squalene and emulsifying agent be placed in oil phase pot, stirring is simultaneously
70-80 DEG C is heated to, is uniformly mixing to obtain oil phase A；
Water is put into S2, aqueous phase pot, and adds hyaluronic acid, fucoidin and allantoin and is stirred and heated to 50-60 DEG C,
Stir to obtain aqueous phase B；
S3, the oil phase A that step S1 is obtained and the aqueous phase B that step S2 is obtained mixed into obtain material C；
S4, the material C that step S3 is obtained is cooled to 30-40 DEG C, adds niacinamide and glutathione and stir, drop
Ceramide is added after to room temperature and preservative produces.
P-Cymene CAS：8008-93-3；Ceramide CAS：100403-19-8；Squalene CAS：111-02-
4；Hyaluronic acid CAS：9004-61-9；Fucoidin CAS：9072-19-9；Allantoin CAS：97-59-6；Niacinamide
No. CAS：98-92-0；Glutathione CAS：70-18-8；Glycerin monostearate CAS：123-94-4；Phenoxyethanol CAS
Number：122-99-6；Sensiva SC50 CAS：70445-33-9；Bisabolol CAS：515-69-5；Palmitic acid CAS：
57-10-3；Thionyl chloride CAS：7719-09-7；Pentamethyl-diethylenetriamine CAS：3030-47-5.
Pneumatically conveying is the derivative of kojic acid by improvement, and it overcomes kojic acid to light, heat and metal ion
Unstability, kojic acid is maintained again and suppresses the activity of tyrosinase, block the effect of dermal melanin formation, and this suppression
It is more stronger than kojic acid, as a kind of new whitening additive, there is excellent stability and security, additionally as liposoluble
Property whitening active agent, additionally it is possible to be more effectively less readily available for absorption by the skin, while give skin tape to carry out good moisten effect.
Squalene is a kind of lipid unsaponifiable matter, is found from the liver oil of shark, is had and is improved internal super oxygen
Compound mutase SOD activity, enhancing immunity of organisms, anti-aging and the multiple functions such as antifatigue, it is a kind of avirulent to have
The marine biomaterial of preventing disease theraping effect.
Purslane flavones, which has, removes free radical and oxidation resistant effect, can be with delay skin aging, can be with from test example 1-6
Find out that the present invention is mutual using components such as P-Cymene, pneumatically conveying, purslane flavones, fucoidin and glutathione
Coordinate, synergy, the facial mask being prepared has good whitening, moisturizing and antibacterial acne-removing, in skin care and guarantor
Hold moisture of skin and it is elastic while there is antibacterial acne-removing, avoid and easily grown thin because facial mask nutritional ingredient is excessive
The drawbacks of bacterium.
It can be seen that there is the present invention whitening of antibacterial acne-removing to keep facial mask non-stimulated to skin from test example 1-2,
Suitable sensitive skin crowd uses；Facial mask skin whitening, moisturizing positive effect of the present invention is can be seen that from test example 3-4；From test example 5-
6 it can be seen that the present invention is cooperated using components such as P-Cymene, pneumatically conveying and purslane flavones, acted synergistically
With good antibacterial anti-acne effect.
Compared with prior art, the present invention not only has good skin whitening, moisturizing effect, and antibacterial anti-acne effect is good, can
Effectively to solve due to the excessive breed bacteria of facial mask nutritional ingredient and for hebetic young boys and girls fat secretion mistake on the face
More carbuncled worry, and small pox rack after also have the liable to infection problem of blood.
Embodiment
The present invention is described in further details below by specific embodiment, these embodiments are only used for the mesh of illustration
, it is in no way intended to limit protection scope of the present invention.
Embodiment 1-3, comparative example 1-2
Table 1 lists 1-3 of the embodiment of the present invention and comparative example 1-2 facial mask component and parts.
The embodiment of table 1 and comparative example facial mask component and part
A kind of whitening moisturizing face masque with antibacterial acne-removing of embodiment 1
The preparation method of described pneumatically conveying comprises the following steps：
(1) 25.64g palmitic acids and thionyl chloride 23.79g are added into magnetic agitation reactor, then adds 0.5g five
Methyl diethylenetriamine, is heated to 60 DEG C of stirring reaction 2h, and reaction pours into the reactant in magnetic agitation reactor after terminating
Thionyl chloride is evaporated off in 70 DEG C of rotations of distiller, produces palmitoyl chloride；
(2) take 100ml three-necked flasks to add 15g kojic acids, be 5 with 60ml acetone and pyridine volume ratio:1 solution dissolving,
The palmitoyl chloride that 10g steps S1 is obtained is instilled in three-necked flask, is filtered, is dried after being washed at room temperature after reaction 2h with cooling water
Produce.
The extracting method of described purslane flavones is：Purslane 300g is weighed, it is rearmounted that 60 DEG C of dries pulverizings cross 80 mesh sieves
In 500ml conical flasks, with 80 DEG C of backflow 3h of 300ml petroleum ethers, filtrate I and filter residue are obtained；300ml ethanol 85 is used after filter residue drying
DEG C backflow 2h, obtain filtrate II；Merging filtrate I and II, it is concentrated and dried, produces.
The preparation method of the described whitening moisturizing face masque with antibacterial acne-removing comprises the following steps：
S1, P-Cymene, pneumatically conveying, anti-sensitizer, squalene and emulsifying agent be placed in oil phase pot, stirring is simultaneously
70 DEG C are heated to, is uniformly mixing to obtain oil phase A；
Water is put into S2, aqueous phase pot, and adds hyaluronic acid, fucoidin and allantoin and is stirred and heated to 50 DEG C, is stirred
Mix uniform aqueous phase B；
S3, the oil phase A that step S1 is obtained and the aqueous phase B that step S2 is obtained mixed into obtain material C；
S4, the material C that step S3 is obtained is cooled to 30 DEG C, adds niacinamide and glutathione and stir, be down to
Ceramide is added after room temperature and preservative produces.
A kind of whitening moisturizing face masque with antibacterial acne-removing of embodiment 2
Described pneumatically conveying and the preparation method of purslane flavones are similar to Example 1.
The preparation method of the described whitening moisturizing face masque with antibacterial acne-removing comprises the following steps：
S1, P-Cymene, pneumatically conveying, anti-sensitizer, squalene and emulsifying agent be placed in oil phase pot, stirring is simultaneously
75 DEG C are heated to, is uniformly mixing to obtain oil phase A；
Water is put into S2, aqueous phase pot, and adds hyaluronic acid, fucoidin and allantoin and is stirred and heated to 55 DEG C, is stirred
Mix uniform aqueous phase B；
S3, the oil phase A that step S1 is obtained and the aqueous phase B that step S2 is obtained mixed into obtain material C；
S4, the material C that step S3 is obtained is cooled to 35 DEG C, adds niacinamide and glutathione and stir, be down to
Ceramide is added after room temperature and preservative produces.
A kind of whitening moisturizing face masque with antibacterial acne-removing of embodiment 3
Described pneumatically conveying and the preparation method of purslane flavones are similar to Example 1.
The preparation method of the described whitening moisturizing face masque with antibacterial acne-removing comprises the following steps：
S1, P-Cymene, pneumatically conveying, anti-sensitizer, squalene and emulsifying agent be placed in oil phase pot, stirring is simultaneously
80 DEG C are heated to, is uniformly mixing to obtain oil phase A；
Water is put into S2, aqueous phase pot, and adds hyaluronic acid, fucoidin and allantoin and is stirred and heated to 60 DEG C, is stirred
Mix uniform aqueous phase B；
S3, the oil phase A that step S1 is obtained and the aqueous phase B that step S2 is obtained mixed into obtain material C；
S4, the material C that step S3 is obtained is cooled to 40 DEG C, adds niacinamide and glutathione and stir, be down to
Ceramide is added after room temperature and preservative produces.
A kind of whitening moisturizing face masque with antibacterial acne-removing of comparative example 1
The preparation of described pneumatically conveying, purslane flavones and the whitening moisturizing face masque with antibacterial acne-removing
Method is similar to Example 2.
The difference of comparative example 1 and embodiment 2 is：Without pneumatically conveying, increase the content of ceramide.
A kind of whitening moisturizing face masque with antibacterial acne-removing of comparative example 2
The preparation of described pneumatically conveying, purslane flavones and the whitening moisturizing face masque with antibacterial acne-removing
Method is similar to Example 2.
The difference of comparative example 2 and embodiment 2 is：Anti-sensitizer purslane flavones is replaced with into bisabolol.
Test example 1：Safety evaluation
1. test material：Facial mask prepared by embodiment 1-3, comparative example 1-2.
2. subjects：50 people, between 30-50 year, each 25 people of men and women, subjects skin's health, no skin disease allergies,
Meet subject and volunteer inclusion criteria.
3. test method：Device is tried with closed patch experiment method from qualified spot, by tested material about 0.020-
For 0.025ml drops in spot examination device, external application special adhesive tape is covered on subject back, and tested material is removed after 12 hours, is observed respectively
0.5 after removal, dermoreaction in 6,12,24,48 hours, according to《Cosmetics health specification》Middle dermoreaction grade scale records it
As a result.
Human skin patch result is shown：The embodiment 1-3 and comparative example that 50 subjects are prepared by the present invention
1-2 facial masks carry out patch test, and dermoreaction was observed at 0.5,6,12,24,48 hour, wherein 0 there is skin adverse reaction,
Illustrate that experiment facial mask used is safe to use.
Test example 2：Sensitive skin crowd's effect test
1. test material：Facial mask prepared by embodiment 1-3 and comparative example 2.
2. subjects：Female, 25-35 year, 120 people divide 4 groups, and 1-4 groups are prepared using embodiment 1-3 and comparative example 2 respectively
Facial mask.
Skin health：Skin is more sensitive caused by acquired disposition, and every group of skin is almost consistent, causes original
Cause：10 people use steroids product, use the easy allergy of other cosmetics；10 people are quick using the improper caused skin of skin care item
Sense, cuticula are thinning；Skin surface damage, red blood silk are serious caused by 10 people cleaning is improper.
3. test method：The facial mask that every morning is prepared using the present invention, continuous use 1 month, as a result as shown in table 2.
Facial mask effect (unit prepared by the embodiment of table 2 and comparative example：People)
The facial mask that as can be seen from Table 2 prepared by 1-3 of the embodiment of the present invention causes sensitive skin people for sensitive skin crowd
Group's face recovers normal almost without allergic phenomena, cutin and red blood silk disappears, more preferable compared with the effect of comparative example 2, illustrates face of the present invention
Film is cooperated synergy using the component such as P-Cymene, pneumatically conveying, purslane flavones, adaptation that can be good
Allergic human population simultaneously improves its skin performance.And show no allergic phenomena, cutin using the personnel of the participation experiment of the facial mask of embodiment 2
Recovery is normal, red blood silk is wholly absent, and is the preferred embodiments of the present invention.
Test example 3：Suppress tyrosinase activity experiment
The color of human skin and kind of pigment present in skin are relevant with quantity, and wherein melanin is to skin color
Maximum is influenceed, tyrosinase is the most key in the forming process of melanin, and the work of whitening can be played by suppressing tyrosinase activity
With.
It is as follows to suppress tyrosinase activity tests concrete steps：Tetra- groups of sample liquids of A1, A2, B1, B2 are drawn with micropipettor
(distilled water 0.7ml, B1, B2 are wherein incorporated as in A1, A2, B1, B2 and adds testing sample 1ml), it is placed in 37 DEG C of water-baths permanent
Temperature 10 minutes, 0.3ml tyrosinase solutions are then respectively added into A2, B2, it is rapid to move into cuvette after reacting 5 minutes, make
Absorbance is surveyed at 475nm with ultraviolet-spectrophotometer, wherein the testing sample is to be made according to embodiment 1-3 and comparative example 1
Standby facial mask.
Respectively by the absorbance list of reaction solution, tyrosinase inhibition rate is sought by following equation.Inhibiting rate=[1- (B2-
B1)/(A2-A1)] × 100%, wherein A2-A1 is the absorbance change of the reaction solution under the conditions of no inhibitor, and B2-B1 is
The absorbance of reaction solution under the conditions of having inhibitor.
After the facial mask being prepared respectively according to embodiment 1-3 and comparative example 1 is tested according to above-mentioned test procedure, obtain
To according to embodiment 1-3 and the facial mask of the raw material of comparative example 1 preparation to the inhibitory action of tyrosinase, as a result as shown in table 3.
The embodiment of table 3 and comparative example facial mask are to tyrosinase inhibitory action result
As can be seen from Table 3 1-3 of the embodiment of the present invention prepare facial mask for tyrosinase inhibiting rate 80% with
On, and facial mask prepared by comparative example 1 is less than 75% to the inhibiting rate of tyrosinase, illustrates the present invention using P-Cymene, kojic acid
The components such as acid dipalmitate are cooperated, the activity of tyrosinase can preferably be suppressed by acting synergistically.And the inhibiting rate of embodiment 2
Up to 91.7%, it is the preferred embodiments of the present invention.
Test example 4：Moisture retention is evaluated
1. test material：Facial mask prepared by embodiment 1-3 and comparative example 1.
2. subjects：The people's age of female 50 between 20-40 year, is divided into 5 groups, every group of 10 people, 1 group of blank group, remaining 4 groups
The facial mask prepared respectively using embodiment 1-3 and comparative example 1；Health status：Subjects skin's health, no skin disease allergies,
Meet the selected scope of subject's aspiration.
3. test method：The skin elasticity tester MPA580 manufactured using German CK companies, selects constant negative pressure mould
Formula, skin elasticity and water content are tested, everyone tests one group of data in order to avoid injury skin, removes two maximums in each group
Value is with after two minimum values, taking the average value of remaining people.30min is tested after skin cleaning, and subject is sooner or later hard daily
Hold using above-mentioned trial target, be when test is not used respectively skip test, using periocualr skin after 2 weeks, 4 weeks it is elastic with it is aqueous
Measure, it is 450mbar that negative pressure is constant in test process.
Flexibility test explanation：Skin springback capacity when Ua- is without negative pressure；Skin maximum tension amount when Uf- has negative pressure；Ue- is constant
After negative pressure is added on skin, positioning elastic amount of tension；Uv：Uf-Ue is the visco-elastic portions of skin, or stretched for plastic
Amount；Ur：After cancelling negative pressure, skin will restore to the original state rapidly state, the elastic part tension values of recovery process；R2 definition：R2
The ratio between=Ua/Uf, maximum tension amount during with there is negative pressure, ratio illustrates that skin elasticity is better closer to 1；R5 definition：R5=
Ur/Ue, in skin recovery process elastic part with plus negative pressure process and the ratio between elastic part, ratio illustrates skin closer to 1
Elasticity is better；R6 definition：The ratio between R6=Uv/Ue, the plastic and elastic part of skin, ratio is smaller, illustrates skin bullet
Property is better；R7 definition：R7=Ur/Uf, the ratio between elastic part and maximum tension amount in skin recovery process, ratio closer to 1,
Illustrate that skin elasticity is better；Index explanation：Wherein closer to 1, R6 closer to 0, the elasticity of skin is better by R2, R5, R7；Water content
Test specification：Skin moisture content scope is classified：0-33 is water deficient, and 33-66 is normal, and 66-99 is that moisture is full.
4. test result is as shown in table 4 below and table 5.
The flexibility test result table of table 4
As shown in Table 4：Increased considerably using skin R2, R5, R7 after embodiment 1-3 facial mask the 2nd week and the 4th week, the 4th
Zhou Houqi indexes level off to 1, R6 reductions, after the 4th week its exponential approach in 0, and use skin R2 after the facial mask of comparative example 1,
R5, R7 ascensional range and R6 reduce amplitude and are significantly less than embodiment 1-3, illustrate the present invention using P-Cymene, the double palms of kojic acid
The components such as acid esters cooperate, synergy, have good wrinkle resistance.And using the facial mask of embodiment 2 after the 2nd week and the 4th week
Skin R2, R5, R7 increasing degree are maximum, and R6 reduces amplitude maximum, is the preferred embodiments of the present invention.
The water content test result table of table 5
Using embodiment 1-3, skin water content is obvious after the 2nd week and the 4th week compared with the facial mask of comparative example 1 as shown in Table 5
Improve, illustrate the present invention cooperated using the component such as P-Cymene, pneumatically conveying, synergy, have well
Moisturizing effect.And using the facial mask of embodiment 2 after the 2nd week and the 4th week moisture content of skin it is high compared with embodiment 1, embodiment 3, be this hair
Bright preferred embodiment.
Test example 5：Antibacterial tests
1. test material：Facial mask prepared by embodiment 1-3 and comparative example 2.
2. subjects：S. aureus colonies and typhoid bacillus bacterium colony.
3. test method：1) lower floor's aseptic culture medium is prepared：10mL agar mediums are poured into sterilized petri dishes, and make it
Condense.
2) upper strata inoculation medium is prepared：Take 45 DEG C ± 2 DEG C of agar medium 150mL to be put into flask, add bacterium bacterium
It is X to fall sum1Experiment bacterium solution.Vibration flask makes Multiple drug resistance uniform, pours into 5mL in each plate into step1, and make
It condenses, and inoculated agar culture face should use in 1h.
3) plate is respectively placed in 5 big containers of sterile closed grade, adds etc. big in this 5 sealing containers
Small beaker is used to deposit the facial mask of the 2ml according to embodiment 1-3 and the preparation of comparative example 2 respectively, sets and adds in the bottom of small beaker
The heater of hot small beaker promotes the volatilization of facial mask active principle, control gas componant in sealing container all the time with sterile sky
Gas composition is identical.After 24h culture, it is X to detect total number of bacterial colonies in culture medium2, and be calculated according to the following formula thin
Bacterium bacterium colony reduced rate.
Bacterial clump reduced rate=(X1-X2)/X1。
4. result of the test：The anti-bacterial result is shown in Table 6.
Table 6 bacterium colony reduced rate (%) result
| Group | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 2 |
| S. aureus colonies reduced rate | 85.12 | 87.18 | 83.24 | 80.34 |
| Typhoid bacillus bacterium colony reduced rate | 77.24 | 83.45 | 79.36 | 74.18 |
The facial mask that as can be seen from Table 6 prepared by 1-3 of the embodiment of the present invention causes golden grape compared with facial mask prepared by comparative example 2
Coccus bacterium colony and typhoid bacillus bacterium colony reduced rate is higher, effect is more preferable, illustrates the present invention using P-Cymene, the double palmitic acids of kojic acid
The components such as ester, purslane flavones cooperate, growth and breeding of the synergy for bacterium have good inhibiting effect.And
It is the preferred embodiments of the present invention using the gold-coloured staphylococci bacterium colony of embodiment 2 and typhoid bacillus bacterium colony reduced rate highest.
Test example 6：Anti-acne effect is evaluated
1. test material：Facial mask prepared by embodiment 1-3 and comparative example 2.
2. subjects：Female, 25-35 year, 120 people divide 4 groups, and 1-4 groups are prepared using embodiment 1-3 and comparative example 2 respectively
Facial mask.Skin health：Variola caused by various factors, causes reason：Skin oil and fat secretion is vigorous, get angry, pressure is big,
Often stay up late.
3. test method：Using embodiment 1-3 and the facial mask of comparative example 2 once in the morning and once at night, other any anti-acne productions are not applied to
Product.Effect assessment standard：1. dispel completely：Disappeared using all variola after 3 months；It is 2. effective：It is basic using variola after 3 months
Disappear, there is acne print；It is 3. effective：Reduced using variola after 3 months；It is 4. invalid：All variola symptoms are without significant change.As a result such as table
Shown in 7.
The embodiment 1-3 of table 7 and the anti-acne effect of comparative example 2
| Group | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 2 |
| Anti-acne completely/people | 20 | 25 | 19 | 14 |
| Effective/people | 5 | 4 | 6 | 9 |
| Effectively/people | 4 | 1 | 2 | 6 |
| Invalid/people | 1 | 0 | 3 | 1 |
Embodiment 1-3 is obvious relative to the anti-acne effect of comparative example 2 as can be seen from Table 7, and it is more to dispel complete number, wherein
Using the best results of embodiment 2 as the preferred embodiments of the present invention.Illustrate the present invention using P-Cymene, pneumatically conveying,
The components such as purslane flavones cooperate, synergy has good therapeutic effect for anti-acne symptom.
The above is only the preferred embodiment of the present invention, it should be pointed out that be above-mentioned preferred embodiment be not construed as to this
The limitation of invention, protection scope of the present invention should be defined by claim limited range.For the general of the art
For logical technical staff, without departing from the spirit and scope of the present invention, some improvements and modifications can also be made, these improvement
Protection scope of the present invention is also should be regarded as with retouching.
Claims (8)
1. a kind of whitening moisturizing face masque with antibacterial acne-removing, it is characterised in that including following components and its parts by weight：
P-Cymene 0.2-0.4 parts, pneumatically conveying 1-3 parts, anti-sensitizer 0.1-0.5 parts, -3 parts of Cer EOS, spiny dogfish
Alkene 0.5-2.5 parts, hyaluronic acid 0.1-0.5 parts, fucoidin 0.5-3 parts, allantoin 0.5-1.5 parts, niacinamide 2-4 parts, paddy
The sweet peptide 0.01-0.05 parts of Guang, emulsifying agent 1-3 parts, preservative 0.2-0.4 parts and water 65-85 parts.
2. the whitening moisturizing face masque according to claim 1 with antibacterial acne-removing, it is characterised in that by following components
And its parts by weight composition：
It is 0.3 part of P-Cymene, 2 parts of pneumatically conveying, 0.3 part of anti-sensitizer, Cer NS part, 1.5 parts of squalene, transparent
0.3 part of matter acid, 2 parts of fucoidin, 1 part of allantoin, 3 parts of niacinamide, 0.03 part of glutathione, 2 parts of emulsifying agent, preservative 0.3
75 parts of part and water.
3. the whitening moisturizing face masque according to claim 1 or 2 with antibacterial acne-removing, it is characterised in that described
The preparation method of pneumatically conveying comprises the following steps：
(1) 25.64g palmitic acids and thionyl chloride 23.79g are added into magnetic agitation reactor, then adds 0.5g pentamethyls
Diethylenetriamine, 60 DEG C of stirring reaction 2h are heated to, react and the reactant in magnetic agitation reactor is poured into distillation after terminating
Thionyl chloride is evaporated off in 70 DEG C of rotations of device, produces palmitoyl chloride；
(2) take 100ml three-necked flasks to add 15g kojic acids, be 5 with 60ml acetone and pyridine volume ratio:1 solution dissolving, by 10g
The palmitoyl chloride that step S1 is obtained is instilled in three-necked flask, is filtered, is drying to obtain after being washed at room temperature after reaction 2h with cooling water.
4. the whitening moisturizing face masque according to claim 1 or 2 with antibacterial acne-removing, it is characterised in that described
Anti-sensitizer is purslane flavones.
5. the whitening moisturizing face masque according to claim 4 with antibacterial acne-removing, it is characterised in that described dent
The extracting method of amaranth flavones is：Purslane 300g is weighed, 60 DEG C of dries pulverizings are placed in 500ml conical flasks after crossing 80 mesh sieves, are used
80 DEG C of backflow 3h of 300ml petroleum ethers, obtain filtrate I and filter residue；With 85 DEG C of backflow 2h of 300ml ethanol after filter residue drying, filtrate II is obtained；
Merging filtrate I and II, it is concentrated and dried, produces.
6. the whitening moisturizing face masque according to claim 1 or 2 with antibacterial acne-removing, it is characterised in that described
Emulsifying agent is glycerin monostearate.
7. the whitening moisturizing face masque according to claim 1 or 2 with antibacterial acne-removing, it is characterised in that described
Preservative is by Phenoxyethanol and Sensiva SC50 in mass ratio 4:1 composition.
8. the preparation method of the whitening moisturizing face masque with antibacterial acne-removing according to claim any one of 1-7, its
It is characterised by, comprises the following steps：
S1, P-Cymene, pneumatically conveying, anti-sensitizer, squalene and emulsifying agent be placed in oil phase pot, stir and heat
To 70-80 DEG C, oil phase A is uniformly mixing to obtain；
Water is put into S2, aqueous phase pot, and adds hyaluronic acid, fucoidin and allantoin and is stirred and heated to 50-60 DEG C, stirring
It is uniform to obtain aqueous phase B；
S3, the oil phase A that step S1 is obtained and the aqueous phase B that step S2 is obtained mixed into obtain material C；
S4, the material C that step S3 is obtained is cooled to 30-40 DEG C, adds niacinamide and glutathione and stir, be down to room
Ceramide is added after temperature and preservative produces.
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| CN108403621A (en) * | 2018-05-07 | 2018-08-17 | 广州度普生物科技有限公司 | A kind of antibacterial blemish clearing gel of multiple target point and preparation method thereof |
| CN109381355A (en) * | 2018-11-30 | 2019-02-26 | 广州润虹医药科技股份有限公司 | A kind of toner and preparation method thereof |
| CN110420224A (en) * | 2019-07-25 | 2019-11-08 | 江苏华豚药业有限公司 | The saponified application and preparation method thereof of filefish liver oil |
| CN111728887A (en) * | 2020-08-06 | 2020-10-02 | 江西沁华蔓医药科技有限公司 | Moisturizing mask and preparation method thereof |
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