JP6869415B2 - Skin care compositions that improve skin barrier function, methods of manufacturing skin care compositions and skin care products - Google Patents
Skin care compositions that improve skin barrier function, methods of manufacturing skin care compositions and skin care products Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9739—Bryophyta [mosses]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
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Description
本発明は、化粧品技術領域に関し、特に皮膚バリア機能を改善するスキンケア組成物及びその使用方法に関する。 The present invention relates to the field of cosmetic technology, and particularly to a skin care composition for improving a skin barrier function and a method of using the same.
近年、環境汚染、季節の変化、仕事と生活のストレスの増加によって引き起こされる皮膚の敏感性は、人間の健康に影響を与える社会問題となっている。敏感肌の症状を持っている人の数は、大幅に増えており、自分が敏感肌であると思っている人が増えている。 In recent years, skin sensitivities caused by environmental pollution, seasonal changes, and increased work and life stress have become social problems affecting human health. The number of people with sensitive skin symptoms has increased significantly, and more people think they have sensitive skin.
皮膚の敏感性の問題に対する一般的な解決策は、皮膚の物理的バリアを改善することである。皮膚の物理的バリアは、皮脂膜、細胞間脂質、ムコ多糖類などで構成されており、外部からの有害物質の侵入を防ぎ、保湿効果と抗炎症効果を有する。しかしながら、広義な皮膚バリアには、角質層の物理的または機械的バリアに加えて、化学的バリア、微生物バリア、及び免疫バリアなどが含まれる。健康な皮膚は、外部刺激に対して過度に敏感に反応しないことに加えて、水分と油分の分泌量のバランスがよいこと、皮膚が光沢と弾力性を有すること、シワが年齢に相応しいこと、肌色が均一でシミがないこと、日光への反応が正常で病気がないことを満たす必要がある。 A common solution to the problem of skin sensitivity is to improve the physical barrier of the skin. The physical barrier of the skin is composed of a sebaceous membrane, intercellular lipids, mucopolysaccharides, etc., prevents the invasion of harmful substances from the outside, and has a moisturizing effect and an anti-inflammatory effect. However, broader skin barriers include chemical barriers, microbial barriers, immune barriers, and the like, in addition to the physical or mechanical barriers of the stratum corneum. In addition to not being overly sensitive to external stimuli, healthy skin has a good balance of water and oil secretion, the skin is shiny and elastic, and wrinkles are age-appropriate. It is necessary to satisfy that the skin color is uniform and there are no stains, the response to sunlight is normal, and there is no disease.
今まで、スキンケア製品に使用することにより、皮脂分泌、皮膚の弾力性、保湿性、有害な細菌に対する抵抗力などを顕著に改善することができる皮膚バリア機能改善効果を有し、皮膚を全面的にケアすることができる皮膚バリア機能を改善するスキンケア組成物は、まだ発見されていない。 Until now, when used in skin care products, it has the effect of improving the skin barrier function, which can significantly improve sebum secretion, skin elasticity, moisturizing property, resistance to harmful bacteria, etc. No skin care composition has yet been discovered that improves the skin barrier function that can be cared for.
従来技術の欠点又は欠陥を克服するために、本発明の主な目的は、スキンケア製品に使用することにより、皮脂分泌、皮膚の弾力性、保湿性、有害な細菌に対する抵抗力などを顕著に改善することができる皮膚バリア機能改善効果を有する皮膚バリア機能を改善するスキンケア組成物を提供することである。 In order to overcome the shortcomings or deficiencies of the prior art, the main object of the present invention is to significantly improve sebum secretion, skin elasticity, moisturizing property, resistance to harmful bacteria, etc. by using it in skin care products. It is to provide a skin care composition which improves the skin barrier function which has the effect of improving the skin barrier function which can be done.
本発明の他の目的は、上記の皮膚バリア機能を改善するスキンケア組成物の使用方法を提供することである。 Another object of the present invention is to provide a method of using a skin care composition that improves the above-mentioned skin barrier function.
本発明のある様態によれば、前述した皮膚バリア機能を改善するスキンケア組成物は、総重量が１００重量部で、ハナビラタケエキス、モスエキス、スベリヒユエキス、及びＰＣＡ亜鉛を含む。 According to a certain aspect of the present invention, the skin care composition for improving the skin barrier function described above has a total weight of 100 parts by weight and contains sparassis crispa extract, moss extract, purslane extract, and PCA zinc.
ここで、ハナビラタケエキス、モスエキス、スベリヒユエキス、及びＰＣＡ亜鉛の重量比は、４０−８０：１−１０：１０−６０：１−１０である。 Here, the weight ratio of Sparassis crispa extract, moss extract, purslane extract, and PCA zinc is 40-80: 1-10: 10-60: 1-10.
ハナビラタケエキス、モスエキス、スベリヒユエキス、及びＰＣＡ亜鉛の重量比を４０−８０：１−１０：１０−６０：１−１０に調整するだけで、得られるスキンケア組成物をスキンケア製品に使用することにより、皮脂分泌、皮膚の弾力性、保湿性、有害な細菌に対する抵抗力などを顕著に改善することができる皮膚バリア機能改善効果を得られる。ハナビラタケエキス、モスエキス、スベリヒユエキス、及びＰＣＡ亜鉛の重量比が大きすぎる場合、スキンケア組成物をスキンケア製品に使用すると、溶解性が低くなり、安定した組成物が得られない。ハナビラタケエキス、モスエキス、スベリヒユエキス、及びＰＣＡ亜鉛の重量比が小さすぎる場合、スキンケア組成物をスキンケア製品に使用すると、改善効果が得られない。好ましくは、ハナビラタケエキス、モスエキス、スベリヒユエキス、及びＰＣＡ亜鉛の重量比は、５０−７０：１−５：２０−５０：１−５である。 By simply adjusting the weight ratio of Hanabira bamboo extract, moss extract, purslane extract, and PCA zinc to 40-80: 1-10: 10-60: 1-10, the resulting skin care composition can be used in skin care products. It is possible to obtain a skin barrier function improving effect that can remarkably improve sebum secretion, skin elasticity, moisturizing property, resistance to harmful bacteria, and the like. If the weight ratio of Sparassis crispa extract, Moss extract, Purslane extract, and PCA zinc is too large, the use of the skin care composition in skin care products will result in poor solubility and a stable composition will not be obtained. If the weight ratio of Sparassis crispa extract, Moss extract, Purslane extract, and PCA zinc is too small, the use of the skin care composition in skin care products will not produce any improving effect. Preferably, the weight ratio of Sparassis crispa extract, moss extract, purslane extract, and PCA zinc is 50-70: 1-5: 20-50: 1-5.
ハナビラタケエキスの生産プロセスは、論文《ハナビラタケ多糖の抽出、分離精製及び生物活性の研究》を参照されたい。工業化生産プロセスにおいて、製品が比較的複雑で、精製などの工程が省略されるため、具体的なプロセスにはある程度の違いがある。 For the production process of Sparassis crispa extract, refer to the paper "Extraction of Sparassis crispa polysaccharide, separation and purification, and research on biological activity". In the industrial production process, the product is relatively complicated and steps such as refining are omitted, so there are some differences in the specific process.
ここで、モスエキスの生産プロセスは以下の通りである。洗浄されたヒメツリガネゴケに無菌水を加え、高速ミキサで機械的に粉砕し細胞壁破壊処理を行った後に、８０−９０℃の高温で１時間保温し、ろ過することにより透明な液体が得られ、噴霧乾燥することにより粉末状物質が得られる。 Here, the production process of moss extract is as follows. Sterile water is added to the washed Himetsuriganegoke, and it is mechanically crushed with a high-speed mixer to destroy the cell wall. Then, it is kept warm at a high temperature of 80-90 ° C. for 1 hour and filtered to obtain a transparent liquid, which is then sprayed. A powdery substance is obtained by drying.
ここで、スベリヒユエキスの生産プロセスは、花安堂生物科技集団有限公司の特許文献（スベリヒユの抽出液の製造方法、ＺＬ２０１６１０１００８１５．６）を参照されたい。 Here, for the production process of purslane extract, refer to the patent document of Hanayasudo Biotechnology Group Co., Ltd. (Method for producing purslane extract, ZL201610100815.6).
ここで、前記スキンケア組成物的ｐＨは、４．０−６．５である。 Here, the skin care composition pH is 4.0-6.5.
また、本発明の他の様態によれば、前述したスキンケア組成物をスキンケア製品として使用する使用方法が公開される。 Further, according to another aspect of the present invention, a method of using the above-mentioned skin care composition as a skin care product is disclosed.
ここで、前記スキンケア組成物の添加量は、スキンケア製品の総重量の１−２０ｗｔ％である。 Here, the amount of the skin care composition added is 1 to 20 wt% of the total weight of the skin care product.
従来の技術に比べ、本発明の態様は、下記の有益な効果を奏する。
本発明では、ハナビラタケエキス、モスエキス、スベリヒユエキス、及びＰＣＡ亜鉛を特定の重量比で配合することにより、スキンケア組成物が得られる。それをスキンケア製品に使用することにより、皮脂分泌、皮膚の弾力性、保湿性、有害な細菌に対する抵抗力などを顕著に改善することができる皮膚バリア機能改善効果を得られ、皮膚を全面的にケアすることができる。
Compared with the prior art, the embodiments of the present invention have the following beneficial effects.
In the present invention, a skin care composition can be obtained by blending Sparassis crispa extract, Moss extract, Purslane extract, and PCA zinc in a specific weight ratio. By using it in skin care products, it is possible to obtain a skin barrier function improving effect that can significantly improve sebum secretion, skin elasticity, moisturizing property, resistance to harmful bacteria, etc. Can be cared for.
以下、具体的な実施形態により本発明を詳しく説明する。以下の実施例は本発明の好ましい実施形態であるが、本発明の実施形態を限定するものではない。 Hereinafter, the present invention will be described in detail according to specific embodiments. The following examples are preferred embodiments of the present invention, but do not limit the embodiments of the present invention.
各性能指標の測定方法は以下の通りである。
１）皮脂分泌の減少量についての評価方法
被験者集団：１８−３５歳、健常な中国人の男性と女性の被験者、脂性肌
被験者数：３０人
試用部位：顔部
使用方法：朝晩洗顔した後、適量のテストサンプルを顔部に塗布し、吸収されるまで軽くマッサージする
使用時間：８Ｗ
評価方法：被験者が試験サンプルを使用する前、使用した２Ｗ後、４Ｗ後、８Ｗ後に、マルチプローブ皮膚測定システムＭＰＡ１０＋ＭＰＡ５８０（Ｃ＆Ｋ）のＳＥＢＵＭＥＴＥＲ測定プローブにより同じ部位の皮脂量を統計し、平均値を取り、初期値と比較して油脂分泌減少率を計算する。
The measurement method of each performance index is as follows.
1) Evaluation method for the amount of decrease in sebum secretion Subject group: 18-35 years old, healthy Chinese male and female subjects, oily skin Number of subjects: 30 Trial site: Face Usage: After washing the face in the morning and evening Apply an appropriate amount of test sample to the face and massage lightly until it is absorbed. Usage time: 8W
Evaluation method: Before the subject uses the test sample, after 2W, 4W, and 8W, the sebum amount of the same site is statistic using the SEBUMETER measurement probe of the multi-probe skin measurement system MPA10 + MPA580 (C & K), and the average value is taken. , Calculate the rate of decrease in sebum secretion by comparing with the initial value.
２）皮膚弾力性改善度についての評価方法
被験者集団：１８−３５歳、健常な中国人の男性と女性の被験者
被験者数：３０人
試用部位：顔部
使用方法：朝晩洗顔した後、適量のテストサンプルを顔部に塗布し、吸収されるまで軽くマッサージする
使用時間：８Ｗ
評価方法：被験者が試験サンプルを使用する前、使用した２Ｗ後、４Ｗ後、８Ｗ後に、マルチプローブ皮膚測定システムＭＰＡ１０＋ＭＰＡ５８０（Ｃ＆Ｋ）のＭＰＡ５８０測定プローブにより同じ部位の皮膚の弾性値を統計し、平均値を取り、初期値と比較して弾力性改善率を計算する（高弾性値は改善があることを示す）。
2) Evaluation method for improvement of skin elasticity Subject group: 18-35 years old, healthy Chinese male and female subjects Number of subjects: 30 Trial site: Face Usage: After washing the face in the morning and evening, an appropriate amount of test Apply the sample to the face and massage lightly until absorbed. Usage time: 8W
Evaluation method: Before the test sample was used by the subject, after 2W, 4W, and 8W, the elasticity value of the skin at the same site was statistic using the MPA580 measurement probe of the multi-probe skin measurement system MPA10 + MPA580 (C & K), and the average value. And calculate the elasticity improvement rate by comparing with the initial value (high elasticity value indicates that there is improvement).
３）経皮水分喪失の改善率についての評価方法
被験者集団：１８−３５歳、健常な中国人の男性と女性の被験者
被験者数：３０人
試用部位：顔部
使用方法：朝晩洗顔した後、適量のテストサンプルを顔部に塗布し、吸収されるまで軽くマッサージする
使用時間：８Ｗ
評価方法：被験者が試験サンプルを使用する前、使用した２Ｗ後、４Ｗ後、８Ｗ後に、マルチプローブ皮膚測定システムＭＰＡ１０＋ＭＰＡ５８０（Ｃ＆Ｋ）のＴｅｗａｍｅｔｅｒ ＴＭ３００測定プローブにより同じ部位の経皮水分喪失量を統計し、平均値を取り、初期値と比較して経皮水分喪失の改善率を計算する（経皮水分喪失量が減少することは改善があることを示す）。
3) Evaluation method for improvement rate of transdermal water loss Subject group: 18-35 years old, healthy Chinese male and female subjects Number of subjects: 30 Trial site: Face Usage: Appropriate amount after washing face in the morning and evening Apply the test sample of No. 1 to the face and massage lightly until it is absorbed. Usage time: 8W
Evaluation method: Before the test sample was used, after 2W, 4W, and 8W, the amount of transdermal water loss at the same site was statistic using the Tewameter TM300 measurement probe of the multi-probe skin measurement system MPA10 + MPA580 (C & K). Take the average value and calculate the improvement rate of percutaneous water loss compared to the initial value (decrease in percutaneous water loss indicates improvement).
４）菌種の菌残存率についての評価方法
１０ｇのサンプルを取り、純水で１００ｇに１０倍希釈し、１ｇのＴｗｅｅｎ ８０を加えて製品中の防腐剤を阻害し、１ｍｌの細菌懸濁液を接種して均一に攪拌し、細菌懸濁液の濃度は、１０6〜１０7ＣＦＵ／ｍｌである。接種したサンプルを３０±２℃のインキュベーターに入れて培養し、２４ｈ後にサンプルを採取してコロニーカウントする。異なる種類の微生物は、単独で接種する必要がある。コロニーの総数が初期値から５０−１００％増加することを「＋＋＋」として記録し、コロニーの総数が初期値から２０−５０％増加することを「＋＋」として記録し、コロニーの総数が初期値から０−２０％増加することを「＋」として記録し、コロニーの総数が初期値から減少することを「−」として記録する。
4) Evaluation method for bacterial survival rate of bacterial species Take a 10 g sample, dilute it 10 times to 100 g with pure water, add 1 g of Tween 80 to inhibit the preservative in the product, and 1 ml of bacterial suspension. stirring uniformly inoculated with the concentration of the bacterial suspension is 10 6 ~10 7 CFU / ml. The inoculated sample is placed in an incubator at 30 ± 2 ° C. and cultured, and after 24 hours, the sample is collected and colony count is performed. Different types of microorganisms need to be inoculated alone. A 50-100% increase in the total number of colonies from the initial value is recorded as "++++", a 20-50% increase in the total number of colonies from the initial value is recorded as "++", and the total number of colonies is the initial value. A 0-20% increase from is recorded as a "+" and a decrease in the total number of colonies from the initial value is recorded as a "-".
実施例Ａ１−Ａ５及び比較例Ｂ１−Ｂ４：スキンケア組成物の製造
表１の比率でハナビラタケエキス、モスエキス、スベリヒユエキス、及びＰＣＡ亜鉛を常温で混合し、均一に撹拌することにより、スキンケア組成物が得られる。
Example A1-A5 and Comparative Example B1-B4: Production of skin care composition Sparassis crispa extract, moss extract, purslane extract, and PCA zinc are mixed at room temperature in the ratio shown in Table 1 and uniformly stirred to obtain a skin care composition. can get.
実施例１−５及び比較例１−４：スキンケア組成物の使用方法
表２の比率で前述より得られたスキンケア組成物を４５℃以下の温度でスキンケア製品に加え、均一に撹拌する。具体的な製造方法は以下の通りである。室温でＬｅｃｉｇｅｌ、Ａｒｉｓｔｏｆｌｅｘ ＡＶＣ、一部のグリセリン９０％、ポリエチレングリコール−８、１，２−ペンタンジオール、ビス−ＰＥＧ−１８メチルエーテルジメチルシラン、フェノキシエタノール及びグリチルリチン酸二カリウムを純水に加え、粉末が完全に湿った後、７０℃まで加熱し、事前に混合したＰＥＧ−６０水添ヒマシ油、トリエチルヘキサノイン及び残りのグリセリン１０％を加え、約１０００ｒｐｍで高速攪拌し、混合、均一化した後に、４５℃以下の温度に冷却し、事前に調製したスキンケア組成物を加える。関連する各性能指標の測定結果を表３−６に示す。
Examples 1-5 and Comparative Example 1-4: How to use the skin care composition The skin care composition obtained from the above in the ratio shown in Table 2 is added to the skin care product at a temperature of 45 ° C. or lower, and the mixture is uniformly stirred. The specific manufacturing method is as follows. At room temperature, Lecigel, Aristoflex AVC, 90% glycerin, polyethylene glycol-8, 1,2-pentanediol, bis-PEG-18 methyl ether dimethylsilane, phenoxyethanol and dipotassium glycyrrhizinate were added to pure water to form a powder. After completely moistening, heat to 70 ° C., add premixed PEG-60 hydrogenated castor oil, triethylhexanoin and the remaining 10% glycerin, stir at high speed at about 1000 rpm, mix and homogenize, and then. Cool to a temperature below 45 ° C. and add the pre-prepared skin care composition. The measurement results of each related performance index are shown in Table 3-6.
Claims (6)
ことを特徴とする皮膚バリア機能を改善するスキンケア組成物。 The total weight is 100 parts by weight, Sparassis crispa extract, saw including Hime Adenophora moss extract, Portulaca oleracea extract, and the PCA zinc, the Sparassis crispa extract, the Princess Adenophora moss extract, the purslane extract, and the weight ratio of the PCA zinc, 40-80: 1 A skin care composition that improves skin barrier function, characterized by being -10: 10-60: 1-10.
ことを特徴とする請求項１に記載の皮膚バリア機能を改善するスキンケア組成物。 The skin according to claim 1 , wherein the weight ratio of the sparassis crispa extract, the physcomitrella patens extract , the purslane extract, and the PCA zinc is 50-70: 1-5: 20-50: 1-5. A skin care composition that improves the barrier function.
ことを特徴とする請求項１に記載の皮膚バリア機能を改善するスキンケア組成物。 The skin care composition for improving the skin barrier function according to claim 1, wherein the pH of the skin care composition is 4.0-6.5.
前記ハナビラタケエキスは、ハナビラタケを無菌水に加え、高温殺菌、酵素分解した後に、防腐剤を加え、ろ過し、殺菌することにより水溶液として得られ、
前記ヒメツリガネゴケエキスは、ヒメツリガネゴケを機械的に粉砕し細胞壁破壊処理を行った後に、無菌水を加え、高温で抽出し、ろ過し、噴霧乾燥することにより粉末状物質として得られ、
前記スベリヒユエキスは、スベリヒユを切断し、粉砕した後に、無菌水を加え、高温で攪拌し、ろ過し、防腐剤を加えることにより水溶液として得られる、
ことを特徴とするスキンケア組成物の製造方法。 The method for producing a skin care composition according to claim 1.
The Sparassis crispa extract is obtained as an aqueous solution by adding Sparassis crispa to sterile water, sterilizing at high temperature, enzymatically decomposing, adding a preservative, filtering, and sterilizing.
The Physcomitrella patens extract is obtained as a powdery substance by mechanically crushing Physcomitrella patens, cell wall destruction treatment, then adding sterile water, extracting at high temperature, filtering, and spray-drying.
The purslane extract can be obtained as an aqueous solution by cutting purslane, pulverizing it, adding sterile water, stirring it at a high temperature, filtering it, and adding a preservative.
A method for producing a skin care composition.
前記スキンケア組成物の添加量は、前記スキンケア製品の総重量の１−２０ｗｔ％である
ことを特徴とするスキンケア製品。 The skin care product according to claim 5.
The amount of the skin care composition, skin care products, characterized in that said a 1-20Wt% of the total weight of the skin care products.
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