WO2020097982A1 - Essential oil composition for scalp care and use - Google Patents

Essential oil composition for scalp care and use Download PDF

Info

Publication number
WO2020097982A1
WO2020097982A1 PCT/CN2018/117883 CN2018117883W WO2020097982A1 WO 2020097982 A1 WO2020097982 A1 WO 2020097982A1 CN 2018117883 W CN2018117883 W CN 2018117883W WO 2020097982 A1 WO2020097982 A1 WO 2020097982A1
Authority
WO
WIPO (PCT)
Prior art keywords
essential oil
scalp
oil composition
scalp care
oil
Prior art date
Application number
PCT/CN2018/117883
Other languages
French (fr)
Chinese (zh)
Inventor
龚盛昭
石磊
Original Assignee
广东轻工职业技术学院
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 广东轻工职业技术学院 filed Critical 广东轻工职业技术学院
Publication of WO2020097982A1 publication Critical patent/WO2020097982A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

Definitions

  • the invention belongs to the field of cosmetics, and particularly relates to an essential oil composition for scalp care and its application.
  • a healthy scalp ecological environment is maintained by three major balances: oil, flora, and metabolic balance. If the three major balanced environments are out of balance, the scalp is prone to oil and becomes greasy, harmful bacteria grow in large numbers, and itchy head appears. At the same time, the scalp cuticle is metabolized too quickly to form dandruff. In addition, the scalp is the second thinnest skin in the human body, and its aging speed is 6 times faster than that of the face. The wind, sun, dyeing, and hot air drying of the hair will cause the scalp to be dry, prone to aging, and inflammation. It will also dry the hair, split the hair, damage the scales, and make the hair fragile.
  • humectants such as glycerin and some conditioning agents such as cationic polymers or silicone oil.
  • the moisturizing agent in the care products has a short residence time on the hair and is not easy to be absorbed in time, and the cationic polymer or silicone oil will be adsorbed on the scalp and hair. Long-term use will not only prevent the scalp from absorbing the effective ingredients, but also bring Abnormal metabolism of scalp microenvironment, hair is easy to greasy and so on. Remaining cleansing products can solve some hair problems, but often bring negative effects such as greasiness, sticky feel and white flakes after use.
  • Essential oil has a small molecular weight, can easily penetrate the skin and be absorbed, and enter the deep layer of the skin. It has a very good effect on scalp blood circulation, revitalizing hair roots and promoting hair growth. Essential oil hair care products are gradually favored by people.
  • CN201810008867X discloses a scalp care essential oil and its preparation process, which consists of: tea tree seeds, lavender, basil, turmeric, black sesame, Shouwu, ginseng, rosemary; the scalp care essential oil can effectively care for the scalp, using plants
  • He Chinese medicine has the functions of astringing pores, promoting cell regeneration, promoting blood circulation, conditioning oily scalp, reducing the damage caused by traditional chemical shampoo to the scalp, and protecting the scalp.
  • CN2016108082475 discloses an oily scalp hair growth essential oil composed of: rosemary oil, geranium essential oil, lavender essential oil, sandalwood oil, ylang oil, lemon oil, eucalyptus essential oil, patchouli oil, happy sage essential oil Jojoba oil; can promote hair growth in the scalp area, inhibit excessive secretion of scalp oil, and is rich in vitamins and minerals, improve the absorption and maintenance of external water by the hair follicles, and repair the damaged keratinocytes .
  • CN201710940858X discloses a scalp care essential oil that effectively relieves neurogenic pruritus, which consists of manuka essential oil, tea tree essential oil, and oxidized corn oil.
  • the scalp care essential oil of the present invention effectively relieves neurogenic stubborn itching.
  • the primary object of the present invention is to provide an essential oil composition for scalp care.
  • the present invention provides an essential oil composition having scalp blood circulation, promoting cell growth, activating hair roots to promote hair growth, and having the effect of removing scalp acne and dandruff.
  • Another object of the present invention is to provide the use of the above-mentioned essential oil composition for scalp care.
  • An essential oil composition for scalp care made of the following weight percent components: ginger essential oil 0.05-10.0%; citronella essential oil 0.1-5.0%; tea tree essential oil 0.05-6.0%; frankincense essential oil 0.1-6.0%; cedar essential oil 0.1 ⁇ 6.0%; the base oil is the balance.
  • the essential oil composition for scalp care is made of the following weight percent components: ginger essential oil 0.1-8.0%; citronella essential oil 0.1-3.0%; tea tree essential oil 0.1-5.0%; frankincense essential oil 0.1-5.0 %; Cedar essential oil 0.1 to 4.0%; base oil is the balance.
  • the essential oil composition for scalp care is made of the following components by weight: ginger essential oil 1.1-2.0%; citronella essential oil 0.5-0.6%; tea tree essential oil 0.7-0.8%; frankincense essential oil 0.9- 1.3%; cedar essential oil 0.8-1.3%; base oil is the balance.
  • the essential oil composition for scalp care is made of the following components by weight: ginger essential oil 1.5%; citronella essential oil 0.5%; tea tree essential oil 0.7%; frankincense essential oil 1.2%; cedar essential oil 1.1%; foundation Oil is the balance.
  • the essential oil composition for scalp care is made of the following components by weight: ginger essential oil 1.2%; citronella essential oil 0.6%; tea tree essential oil 0.8%; frankincense essential oil 1.2%; cedar essential oil 1.2%; foundation Oil is the balance.
  • the essential oil composition for scalp care is made of the following weight percent components: ginger essential oil 1.1%; citronella essential oil 0.5%; tea tree essential oil 0.8%; frankincense essential oil 1.3%; cedar essential oil 1.3%; foundation Oil is the balance.
  • the essential oil composition for scalp care is made of the following components by weight: ginger essential oil 2.0%; citronella essential oil 0.6%; tea tree essential oil 0.7%; frankincense essential oil 0.9%; cedar essential oil 0.8%; foundation Oil is the balance.
  • the base oil mentioned above is a mixture of one or more of grape seed oil, wheat germ oil, olive oil and jojoba oil.
  • Another object of the present invention is to provide the use of the above-mentioned essential oil composition for scalp care in cosmetics.
  • the present invention adopts the following technical solutions:
  • An application of an essential oil composition for scalp care in the preparation of cosmetics which contains the essential oil composition for scalp care, and the amount added in cosmetics is 0.1 to 50% in mass fraction (preferably 0.2 ⁇ 25%).
  • the present invention also provides a cosmetic for scalp care, which contains the above-mentioned essential oil composition for scalp care.
  • the cosmetics contain the above-mentioned essential oil composition for scalp care in a mass fraction of 0.1 to 50% (preferably 0.2 to 25%).
  • the cosmetics are: liquids, lotions, creams, sprays, essences, essential oils, soaps, and care products.
  • the present invention provides a scalp massage essential oil, which includes components as follows:
  • the present invention provides a scalp care shampoo, including the following mass fraction components:
  • the present invention provides a scalp care conditioner, which includes components as follows:
  • the essential oil composition for scalp care of the present invention is guided by Junchen Zuoshen's traditional Chinese medicine formula theory and obtained through extensive experimental research by the inventor. It is selected from ginger essential oil, citronella essential oil, tea tree essential oil, frankincense essential oil, cedar essential oil The best formula can be obtained by carrying out the compatibility experiment according to a specific ratio.
  • the ginger essential oil in the composition of the present invention is a monarch medicine, which has the effects of promoting blood circulation and stasis, promoting blood circulation, and promoting hair growth; citronella essential oil and cedar essential oil are ministerial medicines, and both citronella essential oil and cedar essential oil have significant dredge pores, oil control, Sterilization and removal of scalp acne; tea tree essential oil is an adjuvant with strong antibacterial and anti-dandruff effects; frankincense essential oil is a medicine, frankincense essential oil has antibacterial properties, promotes scarring of wounds, enhances cell activity, and promotes cell regeneration.
  • the present invention has the following advantages and effects:
  • the blood circulation and cell growth promoting effects of the essential oil composition are used to activate hair roots to promote hair growth, and the sterilizing and oil controlling effects of the essential oil composition are used Removes scalp acne to prevent hair loss, and uses the moisturizing effect and anti-free radical effect of the essential oil composition to achieve anti-dandruff effect, thereby achieving scalp care goals.
  • test methods without specific test conditions are generally based on conventional test conditions or test conditions recommended by the manufacturer.
  • Example 1 An essential oil composition for scalp care (I)
  • An essential oil composition for scalp care made of the following weight percent components: ginger essential oil 1.5%; citronella essential oil 0.5%; tea tree essential oil 0.7%; frankincense essential oil 1.2%; cedar essential oil 1.1%; grape seed oil remaining the amount.
  • Example 2 An essential oil composition for scalp care (II)
  • An essential oil composition for scalp care made of the following weight percent components: ginger essential oil 1.2%; citronella essential oil 0.6%; tea tree essential oil 0.8%; frankincense essential oil 1.2%; cedar essential oil 1.2%; jojoba oil for the rest the amount.
  • Example 3 An essential oil composition for scalp care (III)
  • An essential oil composition for scalp care made of the following weight percent components: ginger essential oil 1.1%; citronella essential oil 0.5%; tea tree essential oil 0.8%; frankincense essential oil 1.3%; cedar essential oil 1.3%; olive oil as the balance .
  • Example 4 An essential oil composition for scalp care (IV)
  • An essential oil composition for scalp care made of the following weight percent components: ginger essential oil 2.0%; citronella essential oil 0.6%; tea tree essential oil 0.7%; frankincense essential oil 0.9%; cedar essential oil 0.8%; wheat germ oil remaining the amount.
  • the test method is the Oxford Cup method (also called the tube and dish method), which is a common method for determining the potency of antibiotics at home and abroad, and is also a method prescribed by the multinational pharmacopoeia.
  • the samples to be tested are judged to be Malassezia (Pityrosporum pityrosporum), Malassezia furfur (Pityrosporum orbiculare) in Latin, purchase unit: Guangdong Provincial Microbial Culture Collection Center, GIM2.181 ) Inhibition.
  • Test sample The products prepared in Example 1 and Comparative Examples 1 to 6 were diluted with olive oil to 5 times as the test sample.
  • test bacteria began to grow
  • sample to be tested spread around with the Oxford cup as the origin, forming a circular area where the colony could not grow, which was the "bacteriostatic circle".
  • the sensitivity level is determined according to the diameter of the bacteriostatic circle.
  • the diameter of the bacteriostatic circle For the judgment standard, refer to Table 2 below.
  • Example 1 the products of Example 1, Comparative Examples 1 to 6 were diluted with olive oil to 5 times as a sample, and the changes in the skin moisture content of the tester after using the sample were compared.
  • This test refers to the light industry standard "Guide to Evaluation of Moisturizing Efficacy of Cosmetics" to test the moisturizing efficacy of the samples.
  • the principle of this method is: the capacitance method is used to determine the moisture content of the horny layer of the human skin is based on the difference between the dielectric constant of water and other substances. Can represent the moisture content of the scalp.
  • Example 1 and Comparative Examples 1 to 6 were applied to the test site, respectively.
  • the test time points are before the sample application (0h), 1h and 2h after the sample application.
  • the sample application amount is 2.0 ⁇ 0.1 mg / cm 2 .
  • Example 1 of the present invention still has a high moisture content in the skin 2 hours after use, indicating that the essential oil composition prepared by the present invention has a good moisturizing effect.
  • the hydration rate in each time period is lower than that of the sample of Example 1 of the present invention. It can be seen that after the scientific combination of essential oils, the moisturizing effect is improved under the same dosage, and the essential oils play a good synergistic moisturizing and synergistic effect.
  • Example 1 the products prepared in Example 1 and Comparative Examples 1 to 6 were formulated into a sample ethanol solution with a concentration of 1%, and the following experiments were conducted.
  • A1 is the absorbance value of the blank control
  • A2 is the absorbance value of the sample.
  • Hydroxyl radical scavenging rate (%) [A3-A4-(A3-A5)] / A1 ⁇ 100%
  • A3 is the absorbance value of the reaction system before no sample is added;
  • A4 is the absorbance value of the system after the sample is cleared ⁇ OH;
  • A5 is the absorbance value of the system after the blank control is cleared ⁇ OH.
  • Example 1 of the present invention has a superoxide anion scavenging rate of over 85% and a hydroxyl radical scavenging rate of about 85%, indicating that the composition of the present invention has a significant free radical scavenging effect
  • the unilateral essential oils in Comparative Examples 1 to 5 and the base oil in Comparative Example 6 have much better free radical scavenging rate, indicating that after scientific compounding, the composition has a synergistic effect.
  • Subjects A total of 30 volunteers, including 20 women and 10 men, aged 20-40 years.
  • Test method Take a 0.03mL sample with a syringe and place it in the medicine room of the spot test tape. Immediately apply the spot test tape with the sample longitudinally from the lower part to the normal skin of the left forearm. And make the test article evenly distributed. Mark the test site for easy observation. The skin was applied every 24 hours, and half an hour after the patch was uncovered, it was checked in accordance with the terms of the CTFA guidelines (1981). A total of 6 patch tests were carried out. On the 6th day after the application of the patch, additional examinations were carried out in order to observe late reactions. The data was compared using the results of the last inspection. Identify the following Table 6 as the standard:
  • a scalp massage essential oil containing the essential oil composition for scalp care is described in Table 8:
  • Preparation method Mix isododecane, dioctyl carbonate, ethylhexyl hydrogenated olive oleate, unsaponifiable matter of hydrogenated olive oil, vitamin E, and essential oil composition (I), and mix well.
  • a scalp care shampoo containing the essential oil composition for scalp care is described in Table 9:
  • a scalp care conditioner containing the essential oil composition for scalp care is described in Table 10:
  • Preparation method Add behenyl trimethyl ammonium chloride and disodium ethylenediaminetetraacetic acid to deionized water and heat to 80 ° C to form an aqueous phase. Mix glyceryl monostearate, cetearyl alcohol, and polydimethylsiloxane, and heat to 80 ° C to form the oil phase. Add the oil phase and the water phase to the emulsifying pot, stir evenly, after emulsifying and homogenizing for 5 minutes, when stirring and cooling to 50 ° C, add phenoxyethanol, p-hydroxyacetophenone and the essential oil composition (I) of the invention Stir well and cool to 38 ° C, which is a scalp care conditioner.
  • Evaluation samples the products prepared using Application Example 1 and Comparative Example 1.
  • Evaluation method 30 subjects with seborrheic alopecia were selected, all male, aged 30-45 years old. The method of application was to spray the sample on the scalp after each shampoo and massage the scalp for 5 minutes. After 2 months of use, the evaluation was made from five aspects: improvement in hair loss, scalp moisture, scalp refreshing, scalp acne improvement, and hair frizz improvement.
  • Evaluation criteria 1 point-poor, 2 points-poor, 3 points-fair, 4 points-good, 5 points-very good.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)

Abstract

The present invention belongs to the field of cosmetics, and an essential oil composition for scalp care and use are disclosed. The essential oil composition is made from the following components by weight percentages: 0.05 to 10.0% of ginger essential oil; 0.1 to 5.0% of Cymbopogon citratus essential oil; 0.05 to 6.0% of tea essential oil; 0.1 to 6.0% of mastic essential oil; 0.1 to 6.0% of cedar essential oil; and the balance of basic oils. The essential oil composition of the present invention is obtained by means of extensive experimental research by the inventors under the guidance of the theory of monarch, minister, assistant and guide in traditional Chinese medicine prescriptions. In the essential oil composition of the present invention, various components are compounded in a specific proportion to achieve synergistic effects. Effects of the essential oil composition for promoting blood circulation and promoting cell growth are used for promoting hair growth, bactericidal and oil-controlling effects of the essential oil composition are used for removing scalp acne and preventing hair loss, and a moisturizing effect and an anti-free radical effect of the essential oil composition are used for achieving the effect of removing dandruff, thereby achieving the aim of scalp care.

Description

一种头皮护理用精油组合物及应用Essential oil composition for scalp care and application 技术领域Technical field
本发明属于化妆品领域，具体涉及一种头皮护理用精油组合物及应用。The invention belongs to the field of cosmetics, and particularly relates to an essential oil composition for scalp care and its application.
背景技术Background technique
随着人们的生活水平和生活品质的不断提高，消费者对日常生活必备的美容护肤品的要求越来越高，越来越注重“回归自然”倾向植物护肤理念的影响。With the continuous improvement of people's living standards and quality of life, consumers have higher and higher requirements for the beauty skin care products necessary for daily life, and pay more and more attention to the influence of the "return to nature" tendency plant skin care concept.
近年来，由于人们生活节奏加快、熬夜、饮食不规律、烫染头发以及环境污染等因素，导致头皮健康问题日益突出。中国健康教育协会头皮健康研究中心的数据显示，我国60％以上的成年人的头皮都存在不同程度的健康问题。但人们对头皮护理的认知仍处于较低水平，市面上头皮护理产品仍较少。In recent years, scalp health problems have become increasingly prominent due to factors such as accelerated life rhythm, staying up late, irregular diet, perm hair dyeing, and environmental pollution. Data from the China Health Education Association Scalp Health Research Center show that more than 60% of adults in China have scalp health problems to varying degrees. However, people's awareness of scalp care is still at a low level, and there are still few scalp care products on the market.
健康的头皮生态环境由三大平衡维持：油脂、菌群、代谢平衡。如果三大平衡环境失衡，则头皮容易出油，变得油腻，有害菌大量滋生，出现头痒现象，同时，头皮角质层代谢过快，形成头屑。此外，头皮是人体第二薄皮肤，其衰老速度比脸皮快6倍。头发的风吹日晒、染烫、热风吹干等都会导致头皮的干燥、易衰老、发炎等，也会使头发干燥、分叉掉发、毛鳞片受损、发质脆弱。A healthy scalp ecological environment is maintained by three major balances: oil, flora, and metabolic balance. If the three major balanced environments are out of balance, the scalp is prone to oil and becomes greasy, harmful bacteria grow in large numbers, and itchy head appears. At the same time, the scalp cuticle is metabolized too quickly to form dandruff. In addition, the scalp is the second thinnest skin in the human body, and its aging speed is 6 times faster than that of the face. The wind, sun, dyeing, and hot air drying of the hair will cause the scalp to be dry, prone to aging, and inflammation. It will also dry the hair, split the hair, damage the scales, and make the hair fragile.
为解决头皮干燥、易衰老和头发干枯毛躁、毛鳞片受损问题，目前，市面上洗去型洗护产品较多添加甘油等保湿剂和一些阳离子聚合物或硅油等调理剂。但洗护产品中的保湿剂在头发上停留时间短，不易被及时吸收，而阳离子聚合物或硅油会吸附在头皮和头发上，长期使用不仅会阻碍头皮对功效成分的吸收，还会带来头皮微环境代谢异常，头发容易油腻等。留存型洗护产品能解决一些头发问题，但往往带来使用后易油腻、粘手感、白屑等负面作用。In order to solve the problems of dry scalp, aging, dry hair and frizz, and damage to hair scales, at present, rinse-off products on the market often add humectants such as glycerin and some conditioning agents such as cationic polymers or silicone oil. However, the moisturizing agent in the care products has a short residence time on the hair and is not easy to be absorbed in time, and the cationic polymer or silicone oil will be adsorbed on the scalp and hair. Long-term use will not only prevent the scalp from absorbing the effective ingredients, but also bring Abnormal metabolism of scalp microenvironment, hair is easy to greasy and so on. Remaining cleansing products can solve some hair problems, but often bring negative effects such as greasiness, sticky feel and white flakes after use.
精油分子量小，容易渗透皮肤被吸收，并进入皮肤深层，对于头皮活血和赋活毛根、促进毛发生长具有非常好的功效，精油护发品逐渐深受人们的青睐。Essential oil has a small molecular weight, can easily penetrate the skin and be absorbed, and enter the deep layer of the skin. It has a very good effect on scalp blood circulation, revitalizing hair roots and promoting hair growth. Essential oil hair care products are gradually favored by people.
CN201810008867X公开了一种头皮护理精油及其制备工艺，其组成为：茶树籽、薰衣草、罗勒、姜黄、黑芝麻、首乌、人参、迷迭香；该头皮护理精油能够有效的护理头皮，采用植物和中药作为原配方，具有收敛毛孔、促进细胞再生、促进血液循环、调理油性头皮的功效，减少传统化学洗发露对头皮造成的伤害，保护头皮。CN201810008867X discloses a scalp care essential oil and its preparation process, which consists of: tea tree seeds, lavender, basil, turmeric, black sesame, Shouwu, ginseng, rosemary; the scalp care essential oil can effectively care for the scalp, using plants As the original formula, He Chinese medicine has the functions of astringing pores, promoting cell regeneration, promoting blood circulation, conditioning oily scalp, reducing the damage caused by traditional chemical shampoo to the scalp, and protecting the scalp.
CN2016108082475公开了一种油性头皮增发精油，其组成为：迷迭香油、天竺葵精油、薰衣草精油、檀香油、依兰油、柠檬油、尤加利精油、广藿香油、快乐鼠尾草精油、荷荷巴油；可以促进头皮部位的毛发生长，抑制头皮油脂的过分分泌，并且含有丰富的维生素与矿物质，增进毛囊对外界水分的吸收和维持，对头皮受损的角质素细胞起修护作用。CN2016108082475 discloses an oily scalp hair growth essential oil composed of: rosemary oil, geranium essential oil, lavender essential oil, sandalwood oil, ylang oil, lemon oil, eucalyptus essential oil, patchouli oil, happy sage essential oil Jojoba oil; can promote hair growth in the scalp area, inhibit excessive secretion of scalp oil, and is rich in vitamins and minerals, improve the absorption and maintenance of external water by the hair follicles, and repair the damaged keratinocytes .
CN201710940858X公开了一种有效缓解神经源性瘙痒的头皮护理精油，其组成为：麦卢卡精油、茶树精油、氧化玉米油。本发明所述头皮护理精油有效缓解神经源性顽固瘙痒。CN201710940858X discloses a scalp care essential oil that effectively relieves neurogenic pruritus, which consists of manuka essential oil, tea tree essential oil, and oxidized corn oil. The scalp care essential oil of the present invention effectively relieves neurogenic stubborn itching.
发明内容Summary of the invention
为了克服现有技术的缺点与不足，本发明的首要目的在于提供一种头皮护理用精油组合物。本发明以君臣佐使的中医理论为依据，提供一种具有头皮活血、促进细胞生长、赋活毛根从而促进毛发生长，并兼具去除头皮粉刺和头皮屑功效的精油组合物。In order to overcome the shortcomings and deficiencies of the prior art, the primary object of the present invention is to provide an essential oil composition for scalp care. Based on the Chinese medicine theory of Junchen Zuoshen, the present invention provides an essential oil composition having scalp blood circulation, promoting cell growth, activating hair roots to promote hair growth, and having the effect of removing scalp acne and dandruff.
本发明的另一目的在于提供上述一种头皮护理用精油组合物的应用。Another object of the present invention is to provide the use of the above-mentioned essential oil composition for scalp care.
本发明的目的通过下述技术方案实现：The object of the present invention is achieved by the following technical solutions:
一种头皮护理用精油组合物，由如下重量百分比的组分制成：姜精油0.05～10.0％；香茅精油0.1～5.0％；茶树精油0.05～6.0％；乳香精油0.1～6.0％；雪松精油0.1～6.0％；基础油为余量。An essential oil composition for scalp care, made of the following weight percent components: ginger essential oil 0.05-10.0%; citronella essential oil 0.1-5.0%; tea tree essential oil 0.05-6.0%; frankincense essential oil 0.1-6.0%; cedar essential oil 0.1 ～ 6.0%; the base oil is the balance.
优选的，所述的头皮护理用精油组合物，由如下重量百分比的组分制成：姜精油0.1～8.0％；香茅精油0.1～3.0％；茶树精油0.1～5.0％；乳香精油0.1～5.0％；雪松精油0.1～4.0％；基础油为余量。Preferably, the essential oil composition for scalp care is made of the following weight percent components: ginger essential oil 0.1-8.0%; citronella essential oil 0.1-3.0%; tea tree essential oil 0.1-5.0%; frankincense essential oil 0.1-5.0 %; Cedar essential oil 0.1 to 4.0%; base oil is the balance.
进一步优选的，所述的头皮护理用精油组合物，由如下重量百分比的组分制成：姜精油1.1～2.0％；香茅精油0.5～0.6％；茶树精油0.7～0.8％；乳香精油0.9～1.3％；雪松精油0.8～1.3％；基础油为余量。Further preferably, the essential oil composition for scalp care is made of the following components by weight: ginger essential oil 1.1-2.0%; citronella essential oil 0.5-0.6%; tea tree essential oil 0.7-0.8%; frankincense essential oil 0.9- 1.3%; cedar essential oil 0.8-1.3%; base oil is the balance.
优选的，所述的头皮护理用精油组合物，由如下重量百分比的组分制成：姜精油1.5％；香茅精油0.5％；茶树精油0.7％；乳香精油1.2％；雪松精油1.1％；基础油为余量。Preferably, the essential oil composition for scalp care is made of the following components by weight: ginger essential oil 1.5%; citronella essential oil 0.5%; tea tree essential oil 0.7%; frankincense essential oil 1.2%; cedar essential oil 1.1%; foundation Oil is the balance.
优选的，所述的头皮护理用精油组合物，由如下重量百分比的组分制成：姜精油1.2％；香茅精油0.6％；茶树精油0.8％；乳香精油1.2％；雪松精油1.2％；基础油为余量。Preferably, the essential oil composition for scalp care is made of the following components by weight: ginger essential oil 1.2%; citronella essential oil 0.6%; tea tree essential oil 0.8%; frankincense essential oil 1.2%; cedar essential oil 1.2%; foundation Oil is the balance.
优选的，所述的头皮护理用精油组合物，由如下重量百分比的组分制成： 姜精油1.1％；香茅精油0.5％；茶树精油0.8％；乳香精油1.3％；雪松精油1.3％；基础油为余量。Preferably, the essential oil composition for scalp care is made of the following weight percent components: ginger essential oil 1.1%; citronella essential oil 0.5%; tea tree essential oil 0.8%; frankincense essential oil 1.3%; cedar essential oil 1.3%; foundation Oil is the balance.
优选的，所述的头皮护理用精油组合物，由如下重量百分比的组分制成：姜精油2.0％；香茅精油0.6％；茶树精油0.7％；乳香精油0.9％；雪松精油0.8％；基础油为余量。Preferably, the essential oil composition for scalp care is made of the following components by weight: ginger essential oil 2.0%; citronella essential oil 0.6%; tea tree essential oil 0.7%; frankincense essential oil 0.9%; cedar essential oil 0.8%; foundation Oil is the balance.
以上所述的基础油为葡萄籽油、小麦胚芽油、橄榄油、霍霍巴油中的一种或多种的混合物。The base oil mentioned above is a mixture of one or more of grape seed oil, wheat germ oil, olive oil and jojoba oil.
本发明的再一目的在于提供上述一种头皮护理用精油组合物在化妆品中的应用。Another object of the present invention is to provide the use of the above-mentioned essential oil composition for scalp care in cosmetics.
为了达到本发明的这一目的，本发明采取了如下技术方案：In order to achieve this object of the present invention, the present invention adopts the following technical solutions:
一种头皮护理用精油组合物在制备化妆品中的应用，所述化妆品中含有所述的头皮护理用的精油组合物，在化妆品中的添加量以质量分数计为0.1～50％(优选为0.2～25％)。An application of an essential oil composition for scalp care in the preparation of cosmetics, which contains the essential oil composition for scalp care, and the amount added in cosmetics is 0.1 to 50% in mass fraction (preferably 0.2 ~ 25%).
本发明还提供一种头皮护理用化妆品，该化妆品含有上述头皮护理用精油组合物。The present invention also provides a cosmetic for scalp care, which contains the above-mentioned essential oil composition for scalp care.
优选的，该化妆品含有上述以质量分数计为0.1～50％(优选为0.2～25％)的头皮护理用精油组合物。Preferably, the cosmetics contain the above-mentioned essential oil composition for scalp care in a mass fraction of 0.1 to 50% (preferably 0.2 to 25%).
所述的化妆品为：水剂、乳液类、膏霜类、喷雾类、精华类、精油类、皂类、洗护类。The cosmetics are: liquids, lotions, creams, sprays, essences, essential oils, soaps, and care products.
具体的，本发明提供一种头皮按摩精油，包括如下质量分数计的组分：Specifically, the present invention provides a scalp massage essential oil, which includes components as follows:
组分名称Component name 质量分数/％Quality score /%
异构十二烷Isododecane 余量margin
碳酸二辛酯Dioctyl carbonate 32.432.4
氢化橄榄油酸乙基己酯Hydrogenated ethylhexyl oleate 0.50.5
氢化橄榄油不皂化物Hydrogenated olive oil unsaponifiable 0.10.1
维生素EVitamin E 1.01.0
本发明所述的精油组合物Essential oil composition according to the invention 25.025.0
具体的，本发明提供一种头皮护理洗头水，包括如下质量分数计的组分：Specifically, the present invention provides a scalp care shampoo, including the following mass fraction components:
组分名称Component name 质量分数/％Quality score /%
水water 余量margin
椰油酰水解燕麦蛋白钾Cocoyl Hydrolyzed Oat Protein Potassium 28.3028.30
椰油酰谷氨酸二钠Cocoyl glutamate disodium 11.6011.60
聚季铵盐-10Polyquaternium-10 0.230.23
柠檬酸Citric acid 0.450.45
柠檬酸钠Sodium citrate 0.050.05
水解玉米淀粉Hydrolyzed corn starch 0.420.42
对羟基苯乙酮P-hydroxyacetophenone 0.400.40
椰油酰胺甲基MEACocamide methyl MEA 0.550.55
苯氧乙醇Phenoxyethanol 0.450.45
本发明所述的精油组合物Essential oil composition according to the invention 0.200.20
具体的，本发明提供一种头皮护理护发素，包括如下质量分数计的组分：Specifically, the present invention provides a scalp care conditioner, which includes components as follows:
物质名称Substance name 质量分数/％Quality score /%
二十二烷基三甲基氯化铵Behenyl trimethyl ammonium chloride 4.24.2
单硬脂酸甘油酯Glyceryl monostearate 2.12.1
聚二甲基硅氧烷Polydimethylsiloxane 3.23.2
十六十八醇Cetostearyl alcohol 3.43.4
乙二胺四乙酸二钠Disodium EDTA 0.050.05
本发明所述的精油组合物Essential oil composition according to the invention 10.010.0
对羟基苯乙酮P-hydroxyacetophenone 0.30.3
苯氧乙醇Phenoxyethanol 0.40.4
去离子水Deionized water 余量margin
本发明的依据：Basis of the invention:
本发明的一种头皮护理用精油组合物是以君臣佐使的中医组方理论为指导，经发明人大量的实验研究获得的，精选了姜精油、香茅精油、茶树精油、乳香精油、雪松精油按照特定的比例进行配伍实验得到的最佳组方。本发明组合物中姜精油为君药，具有活血化瘀、促进血液循环、促进毛发生长功效；香茅精油和雪松精油为臣药，香茅精油和雪松精油都具有显著的疏通毛孔、控油、杀菌、去除头皮粉刺作用；茶树精油为佐药，具有强效抗菌去头屑功效；乳香精油为使药，乳香精油具有抗菌，促进伤口结疤和增强细胞活性、促进细胞新生的功效。The essential oil composition for scalp care of the present invention is guided by Junchen Zuoshen's traditional Chinese medicine formula theory and obtained through extensive experimental research by the inventor. It is selected from ginger essential oil, citronella essential oil, tea tree essential oil, frankincense essential oil, cedar essential oil The best formula can be obtained by carrying out the compatibility experiment according to a specific ratio. The ginger essential oil in the composition of the present invention is a monarch medicine, which has the effects of promoting blood circulation and stasis, promoting blood circulation, and promoting hair growth; citronella essential oil and cedar essential oil are ministerial medicines, and both citronella essential oil and cedar essential oil have significant dredge pores, oil control, Sterilization and removal of scalp acne; tea tree essential oil is an adjuvant with strong antibacterial and anti-dandruff effects; frankincense essential oil is a medicine, frankincense essential oil has antibacterial properties, promotes scarring of wounds, enhances cell activity, and promotes cell regeneration.
本发明相对于现有技术具有如下的优点及效果：Compared with the prior art, the present invention has the following advantages and effects:
本发明的精油组合物中各种组分按照特定比例进行搭配，达到协同增效， 利用精油组合物的活血和促进细胞生长功效赋活毛根从而促进毛发生长，利用精油组合物的杀菌和控油功效去除头皮粉刺从而防脱发，利用精油组合物的保湿作用和抗自由基作用达到去头皮屑功效，从而达到头皮护理目标。Various components of the essential oil composition of the present invention are matched according to a specific ratio to achieve synergistic synergies. The blood circulation and cell growth promoting effects of the essential oil composition are used to activate hair roots to promote hair growth, and the sterilizing and oil controlling effects of the essential oil composition are used Removes scalp acne to prevent hair loss, and uses the moisturizing effect and anti-free radical effect of the essential oil composition to achieve anti-dandruff effect, thereby achieving scalp care goals.
具体实施方式detailed description
下面结合实施例对本发明作进一步详细的描述，但本发明的实施方式不限于此。The present invention will be described in further detail below with reference to examples, but the embodiments of the present invention are not limited thereto.
下列实施例中未注明具体实验条件的试验方法，通常按照常规实验条件或按照制造厂所建议的实验条件。In the following examples, the test methods without specific test conditions are generally based on conventional test conditions or test conditions recommended by the manufacturer.
实施例1一种头皮护理用精油组合物(Ⅰ)Example 1 An essential oil composition for scalp care (Ⅰ)
一种头皮护理用精油组合物，由如下重量百分比的组分制成：姜精油1.5％；香茅精油0.5％；茶树精油0.7％；乳香精油1.2％；雪松精油1.1％；葡萄籽油为余量。An essential oil composition for scalp care, made of the following weight percent components: ginger essential oil 1.5%; citronella essential oil 0.5%; tea tree essential oil 0.7%; frankincense essential oil 1.2%; cedar essential oil 1.1%; grape seed oil remaining the amount.
实施例2一种头皮护理用精油组合物(Ⅱ)Example 2 An essential oil composition for scalp care (Ⅱ)
一种头皮护理用精油组合物，由如下重量百分比的组分制成：姜精油1.2％；香茅精油0.6％；茶树精油0.8％；乳香精油1.2％；雪松精油1.2％；霍霍巴油为余量。An essential oil composition for scalp care, made of the following weight percent components: ginger essential oil 1.2%; citronella essential oil 0.6%; tea tree essential oil 0.8%; frankincense essential oil 1.2%; cedar essential oil 1.2%; jojoba oil for the rest the amount.
实施例3一种头皮护理用精油组合物(Ⅲ)Example 3 An essential oil composition for scalp care (Ⅲ)
一种头皮护理用精油组合物，由如下重量百分比的组分制成：姜精油1.1％；香茅精油0.5％；茶树精油0.8％；乳香精油1.3％；雪松精油1.3％；橄榄油为余量。An essential oil composition for scalp care, made of the following weight percent components: ginger essential oil 1.1%; citronella essential oil 0.5%; tea tree essential oil 0.8%; frankincense essential oil 1.3%; cedar essential oil 1.3%; olive oil as the balance .
实施例4一种头皮护理用精油组合物(Ⅳ)Example 4 An essential oil composition for scalp care (Ⅳ)
一种头皮护理用精油组合物，由如下重量百分比的组分制成：姜精油2.0％；香茅精油0.6％；茶树精油0.7％；乳香精油0.9％；雪松精油0.8％；小麦胚芽油为余量。An essential oil composition for scalp care, made of the following weight percent components: ginger essential oil 2.0%; citronella essential oil 0.6%; tea tree essential oil 0.7%; frankincense essential oil 0.9%; cedar essential oil 0.8%; wheat germ oil remaining the amount.
对比例1～6单种精油与基础油的组合物Comparative Examples 1 to 6 Combination of single essential oil and base oil
具体组合方式见表1所示。The specific combination is shown in Table 1.
表1Table 1
成分ingredient 对比例1Comparative Example 1 对比例2Comparative Example 2 对比例3Comparative Example 3 对比例4Comparative Example 4 对比例5Comparative Example 5 对比例6Comparative Example 6
姜精油Ginger essential oil 5％5% 00 00 00 00 00
香茅精油Lemongrass essential oil 00 5％5% 00 00 00 00
雪松精油Cedar essential oil 00 00 5％5% 00 00 00
茶树精油Tea tree oil 00 00 00 5％5% 00 00
乳香精油Frankincense essential oil 00 00 00 00 5％5% 00
葡萄籽油grape seed oil 95％95% 95％95% 95％95% 95％95% 95％95% 100％100%
试验例1抑菌圈试验Test Example 1 Bacteriostatic Zone Test
测试方法为牛津杯法(也叫管碟法)，此方法是国内外测定抗生素效价通用方法，也是多国药典规定的方法。通过抑菌圈测试，判断待测样品对马拉色菌(糠秕马拉色菌(糠秕孢子菌)，拉丁文Malassezia furfur(Pityrosporum orbiculare)，购买单位：广东省微生物菌种保藏中心，GIM2.181)的抑制作用。The test method is the Oxford Cup method (also called the tube and dish method), which is a common method for determining the potency of antibiotics at home and abroad, and is also a method prescribed by the multinational pharmacopoeia. Through the bacteriostatic zone test, the samples to be tested are judged to be Malassezia (Pityrosporum pityrosporum), Malassezia furfur (Pityrosporum orbiculare) in Latin, purchase unit: Guangdong Provincial Microbial Culture Collection Center, GIM2.181 ) Inhibition.
测试样品：实施例1和对比例1～6制备的产品用橄榄油稀释至5倍后作为待测样。Test sample: The products prepared in Example 1 and Comparative Examples 1 to 6 were diluted with olive oil to 5 times as the test sample.
以无菌操作，将经过高温灭菌的培养基倒入直径9cm的无菌培养皿中，使每个培养皿有15～20mL的培养基，冷却后，加入0.2mL马拉色菌菌悬液，用涂布棒将培养基表面涂布均匀，用镊子将牛津杯垂直放上相应培养基表面，轻轻加压，使其与培养基接触无空隙，每个平板可放3支小管，分别向各小管中滴加0.1mL的各种待测样，并做好标记，勿使其外溢。马拉色菌：置37℃培养箱厌氧培养2～5天后，观察结果。Aseptically, pour the high-temperature sterilized medium into a sterile petri dish with a diameter of 9 cm so that each dish has 15-20 mL of medium. After cooling, add 0.2 mL of Malassezia suspension , Coat the surface of the culture medium evenly with a coating rod, put the Oxford cup vertically on the surface of the corresponding culture medium with tweezers, and gently pressurize it so that there is no gap in contact with the culture medium. Each plate can hold 3 small tubes Add 0.1mL of each sample to be dropped into each small tube, and mark it well so that it does not overflow. Malassezia: After anaerobic cultivation in a 37 ° C incubator for 2 to 5 days, observe the results.
在培养时，一方面试验菌开始生长，另一方面待测样以牛津杯为原点向四周扩散，形成菌落不能生长的圆形区域，为“抑菌圈”。抑菌圈越大，祛痘效果越好。During the cultivation, on the one hand, the test bacteria began to grow, on the other hand, the sample to be tested spread around with the Oxford cup as the origin, forming a circular area where the colony could not grow, which was the "bacteriostatic circle". The larger the bacteriostatic zone, the better the acne removing effect.
药敏实验的结果，按抑菌圈直径大小判定敏感度高低，判断标准参考下表2。According to the results of the drug susceptibility test, the sensitivity level is determined according to the diameter of the bacteriostatic circle. For the judgment standard, refer to Table 2 below.
表2药物敏感实验判定标准Table 2 Judgment criteria for drug sensitivity experiments
抑菌圈直径(毫米)Diameter of inhibition zone (mm) 敏感度Sensitivity
20以上20 or more 极敏Extremely sensitive
15～2015 ～ 20 高敏Gao Min
10～1410 ～ 14 中敏Zhong Min
10以下10 or less 低敏Hypoallergenic
00 不敏Insensitive
测试结果，如表3所示。The test results are shown in Table 3.
表3抑菌圈试验测试结果Table 3 Test results of the inhibition zone test
Figure PCTCN2018117883-appb-000001
Figure PCTCN2018117883-appb-000001
结果表明，本发明中的实施例1～4抑制马拉色菌效果非常显著，说明精油组合物具有非常好的抗菌去屑效果；而且均比单方精油的效果好，说明精油复配对马拉色菌抑制有协同增效作用。The results show that the examples 1 to 4 of the present invention have very significant inhibitory effects on malassezia, indicating that the essential oil composition has a very good antibacterial and anti-dandruff effect; and they are all better than the effect of the single essential oil, indicating that the essential oil is compounded with malasse Bacterial inhibition has a synergistic effect.
试验例2头皮保湿效果测试Test Example 2 Scalp moisturizing effect test
实验材料：选用实施例1、对比例1～6产品用橄榄油稀释至5倍后作为样品，比较样品在使用后，试用者皮肤含水量的变化。Experimental materials: the products of Example 1, Comparative Examples 1 to 6 were diluted with olive oil to 5 times as a sample, and the changes in the skin moisture content of the tester after using the sample were compared.
本试验参照轻工行业标准《化妆品保湿功效评价指南》对样品进行保湿功效测试。此方法的原理是：采用电容法测定人体皮肤角质层的水分含量是基于水和其他物质的介电常数差异显著，按照皮肤角质层水分含量的不同，测得的皮肤的电容值不同，其参数可代表头皮水分含量。This test refers to the light industry standard "Guide to Evaluation of Moisturizing Efficacy of Cosmetics" to test the moisturizing efficacy of the samples. The principle of this method is: the capacitance method is used to determine the moisture content of the horny layer of the human skin is based on the difference between the dielectric constant of water and other substances. Can represent the moisture content of the scalp.
选取40名染烫发质的受试者，所有受试者无任何头皮过敏史或者头皮疾患史，受试部位无任何异常。受试者女；年龄21～45岁。整个测试过程均在恒温恒湿实验室进行，室温为20℃～22℃，湿度为40％～60％。采用Corneometer CM825(德国Courage+Khazaka公司，购于北京金宏帆)进行测定每个实验部位的水分含量。数值越大，表明角质层含水量越高。选择头部后侧作为测试部位(5cm×5cm)。测试前，受试者统一用同款洗发水洗头，吹干，然后保持一定***平衡30min。分别将实施例1和对比例1～6的样品涂抹于测试部位。测试时间点分别为涂样前(0h)，涂样后1h，2h。样品涂抹量为2.0±0.1mg/cm 2。 Forty permed subjects were selected. All subjects had no history of scalp allergy or scalp disease, and there were no abnormalities at the test site. Subject female; aged 21-45 years old. The entire test process is carried out in a constant temperature and humidity laboratory, with a room temperature of 20 ° C to 22 ° C and a humidity of 40% to 60%. Corneometer CM825 (Courage + Khazaka, Germany, purchased from Beijing Jinhongfan) was used to determine the moisture content of each experimental site. The larger the value, the higher the water content of the stratum corneum. Select the back side of the head as the test site (5cm × 5cm). Before the test, the subjects uniformly washed their hair with the same type of shampoo, dried them, and then maintained a certain posture balance for 30 minutes. The samples of Example 1 and Comparative Examples 1 to 6 were applied to the test site, respectively. The test time points are before the sample application (0h), 1h and 2h after the sample application. The sample application amount is 2.0 ± 0.1 mg / cm 2 .
再通过计算得出志愿者在不同时间间隔点的平均水合率，用公式(1)计算水合率：Then calculate the average hydration rate of volunteers at different time intervals, and calculate the hydration rate using formula (1):
Figure PCTCN2018117883-appb-000002
Figure PCTCN2018117883-appb-000002
结果见表4所示。The results are shown in Table 4.
表4Table 4
Figure PCTCN2018117883-appb-000003
Figure PCTCN2018117883-appb-000003
从表4可以得出，本发明实施例1样品在使用后2小时，皮肤仍具有很高的水分含量，说明本发明制备的精油组合物具有较好的保湿效果。而使用对比例1～6样品，在每个时间段的水合率均比本发明实施例1样品均低。由此可知，精油经过科学组合后，在用量一致的情况下，保湿效果得到提高，精油间起到了良好的协同保湿增效作用。It can be drawn from Table 4 that the sample of Example 1 of the present invention still has a high moisture content in the skin 2 hours after use, indicating that the essential oil composition prepared by the present invention has a good moisturizing effect. Using the samples of Comparative Examples 1 to 6, the hydration rate in each time period is lower than that of the sample of Example 1 of the present invention. It can be seen that after the scientific combination of essential oils, the moisturizing effect is improved under the same dosage, and the essential oils play a good synergistic moisturizing and synergistic effect.
试验例3清除自由基试验Test Example 3 Free radical scavenging test
1、试样的配制1. Preparation of samples
分别将实施例1和对比例1～6制备的产品配成浓度为1％的样品乙醇溶液，进行下面实验。Separately, the products prepared in Example 1 and Comparative Examples 1 to 6 were formulated into a sample ethanol solution with a concentration of 1%, and the following experiments were conducted.
2、对超氧阴离子自由基清除能力评价2. Evaluation of superoxide anion free radical scavenging ability
取0.05mol/L pH＝8.2的Tris-HCl缓冲液4.5mL，于25℃水浴锅中预热20min。再加入1mL样品乙醇溶液和0.4mL 25mmol/L的邻苯三酚溶液，混匀后，于25℃水浴中反应5min，加入8mol/L的HCl 1.0mL终止反应。以Tris-HCl缓冲液作参比，在299nm处测吸光度值。空白对照用1mL样品乙醇溶液的溶剂来替代样品。Take 4.5mL of Tris-HCl buffer with 0.05mol / L pH = 8.2 and preheat in a 25 ° C water bath for 20min. Then add 1 mL of sample ethanol solution and 0.4 mL of 25 mmol / L pyrogallol solution. After mixing, react in a 25 ° C water bath for 5 min. Add 8 mol / L HCl 1.0 mL to stop the reaction. With Tris-HCl buffer as reference, the absorbance value was measured at 299nm. The blank control replaces the sample with 1 mL of sample ethanol solution.
超氧阴离子自由基清除率(％)＝[1－(A2/A1)]×100％Superoxide anion radical scavenging rate (%) = [1－ (A2 / A1)] × 100%
式中A1为空白对照的吸光度值；A2为样品的吸光度值。In the formula, A1 is the absorbance value of the blank control; A2 is the absorbance value of the sample.
3、对羟自由基的清除能力评价3. Evaluation of scavenging ability of hydroxyl radicals
在25mL比色管中依次加入2mmol/L FeSO 4 3mL，1mmol/L H 2O 2 3mL，摇匀，接着加入6mmol/L水杨酸3mL，摇匀，于37℃水浴加热15min后取出，测其吸光度；分别加入一定浓度的待测液，摇匀，继续水浴加热15min，取出测其吸光度。下式为待测液对羟自由基(·OH)的清除率： In a 25mL colorimetric tube, add 2mmol / L FeSO 4 3mL, 1mmol / L H 2 O 2 3mL, shake well, then add 6mmol / L salicylic acid 3mL, shake well, take it out after heating in a 37 ° C water bath for 15min, and measure its Absorbance; add a certain concentration of the test solution, shake well, continue heating in the water bath for 15min, take out and measure its absorbance. The following formula is the clearance rate of the test solution to hydroxyl radical (· OH):
羟自由基清除率(％)＝[A3－A4－(A3－A5)]/A1×100％Hydroxyl radical scavenging rate (%) = [A3-A4-(A3-A5)] / A1 × 100%
式中A3为未加样品前反应体系的吸光度值；A4为样品清除·OH后体系的吸光度值；A5为空白对照清除·OH后体系的吸光度值。In the formula, A3 is the absorbance value of the reaction system before no sample is added; A4 is the absorbance value of the system after the sample is cleared · OH; A5 is the absorbance value of the system after the blank control is cleared · OH.
4、样品抗自由基的对比测试4. Comparative test of samples against free radicals
表5自由基清除率功能评价结果Table 5 Free radical scavenging rate functional evaluation results
Figure PCTCN2018117883-appb-000004
Figure PCTCN2018117883-appb-000004
实验表明，本发明的实施例1精油组合物对超氧阴离子清除率高达85％以上，对羟自由基清除率在85％左右，说明本发明的组合物有显著的清除自由基效果，而且比对比例1～5中单方精油和对比例6基础油对自由基的清除率效果好得多，说明经过科学复配后，组合物间起到了协同增效作用。Experiments show that the essential oil composition of Example 1 of the present invention has a superoxide anion scavenging rate of over 85% and a hydroxyl radical scavenging rate of about 85%, indicating that the composition of the present invention has a significant free radical scavenging effect The unilateral essential oils in Comparative Examples 1 to 5 and the base oil in Comparative Example 6 have much better free radical scavenging rate, indicating that after scientific compounding, the composition has a synergistic effect.
试验例4皮肤刺激性实验Test Example 4 Skin irritation experiment
实验材料：选用实施例1、对比例1～6产品用橄榄油稀释5倍后作为样品。Experimental materials: the products of Example 1, Comparative Examples 1 to 6 were diluted 5 times with olive oil as samples.
受试者：共30名志愿者，其中女性：20名，男性10名，年龄在20～40岁。Subjects: A total of 30 volunteers, including 20 women and 10 men, aged 20-40 years.
试验方法：用注射器取0.03mL样品置于斑试胶带的药室内，立即将置有样品的斑试胶带从下部开始纵向贴于左前臂的正常皮肤上，同时逐个轻压药室以驱除空气，并使试验物均匀分布。试验部位做好标记，以便观察。每隔24小时贴肤一次，揭开贴片后半个小时，则按照CTFA指南(1981年)的术语进行了检查。共进行了6次斑贴实验，贴肤结束后的第6天，为了观察迟发反应，进行了追加检查。数据则利用最后一次检查结果，进行了比较。鉴定以下表6为标准进行：Test method: Take a 0.03mL sample with a syringe and place it in the medicine room of the spot test tape. Immediately apply the spot test tape with the sample longitudinally from the lower part to the normal skin of the left forearm. And make the test article evenly distributed. Mark the test site for easy observation. The skin was applied every 24 hours, and half an hour after the patch was uncovered, it was checked in accordance with the terms of the CTFA guidelines (1981). A total of 6 patch tests were carried out. On the 6th day after the application of the patch, additional examinations were carried out in order to observe late reactions. The data was compared using the results of the last inspection. Identify the following Table 6 as the standard:
表6皮肤刺激鉴定标准Table 6 Identification criteria for skin irritation
等级grade 符号symbol 鉴定标准Identification standard
00 -- 阴性反应：无刺激、无红斑Negative reaction: no irritation, no erythema
11 ±± 可疑反应：轻度红斑Suspicious reaction: mild erythema
22 ++ 弱阳性反应：红斑Weak positive reaction: erythema
33 ++++ 强阳性反应：红斑、丘疹、水疱Strong positive reactions: erythema, papules, blisters
44 ++++++ 极强阳性反应：严重浮肿、大泡Very strong positive reaction: severe edema, large bubbles
试验结果：如表7所示。Test results: as shown in Table 7.
表7皮肤刺激测试结果Table 7 Skin irritation test results
贴皮次数Number of skinning 实施例1Example 1 对比例1Comparative Example 1 对比例2Comparative Example 2 对比例3Comparative Example 3 对比例4Comparative Example 4 对比例5Comparative Example 5 对比例6Comparative Example 6
11 00 1次+1 time + 1次±1 time ± 1次±1 time ± 1次±1 time ± 1次±1 time ± 00
22 00 1次±1 time ± 1次+1 time + 00 00 00 00
33 00 00 00 1次±1 time ± 00 00 00
44 00 00 00 00 1次±1 time ± 00 00
55 00 00 00 00 00 00 00
66 00 00 00 00 00 00 00
合计total 00 1次±,1次+1 time ±, 1 time + 1次±,1次+1 time ±, 1 time + 2次±2 times ± 2次±2 times ± 1次±1 time ± 00
表7结果显示，本发明实施例1精油组合物样品与对比例6基础油样品刺激性相当，均未发现志愿者出现刺激，而且刺激性比对比例1～5单方精油样品低得多。由此可知，精油经过科学组合后，在用量一致的情况下，比单独使用更温和。The results in Table 7 show that the sample of the essential oil composition of Example 1 of the present invention is comparable to the sample of the base oil of Comparative Example 6, and no irritation was found in the volunteers, and the irritation is much lower than that of the samples of unilateral essential oils of Comparative Examples 1 to 5. It can be seen that after scientific combination of essential oils, in the case of consistent dosage, it is more gentle than single use.
应用实施例1头皮按摩精油Application Example 1 Scalp Massage Essential Oil
一种含有所述的头皮护理用的精油组合物的头皮按摩精油，具体配方如表8所示：A scalp massage essential oil containing the essential oil composition for scalp care is described in Table 8:
表8Table 8
组分名称Component name 质量分数/％Quality score /%
异构十二烷Isododecane 余量margin
碳酸二辛酯Dioctyl carbonate 32.432.4
氢化橄榄油酸乙基己酯Hydrogenated ethylhexyl oleate 0.50.5
氢化橄榄油不皂化物Hydrogenated olive oil unsaponifiable 0.10.1
维生素EVitamin E 1.01.0
实施例1制备的精油组合物(Ⅰ)Essential oil composition prepared in Example 1 (Ⅰ) 25.025.0
制备方法：将异构十二烷、碳酸二辛酯、氢化橄榄油酸乙基己酯、氢化橄榄油不皂化物、维E、精油组合物(Ⅰ)混合，搅拌均匀即可。Preparation method: Mix isododecane, dioctyl carbonate, ethylhexyl hydrogenated olive oleate, unsaponifiable matter of hydrogenated olive oil, vitamin E, and essential oil composition (I), and mix well.
应用对比例1普通头皮按摩油Apply Comparative Example 1 Ordinary Scalp Massage Oil
除了不含有本发明的精油组合物(Ⅰ)外，其他与应用实施例1一致。It is the same as Application Example 1 except that it does not contain the essential oil composition (I) of the present invention.
应用实施例2头皮护理洗头水Application Example 2 Scalp Care Shampoo
一种含有所述的头皮护理用的精油组合物的头皮护理洗头水，具体配方如表9所示：A scalp care shampoo containing the essential oil composition for scalp care is described in Table 9:
表9Table 9
组分名称Component name 质量分数/％Quality score /%
水water 余量margin
椰油酰水解燕麦蛋白钾Cocoyl Hydrolyzed Oat Protein Potassium 28.3028.30
椰油酰谷氨酸二钠Cocoyl glutamate disodium 11.6011.60
聚季铵盐-10Polyquaternium-10 0.230.23
柠檬酸Citric acid 0.450.45
柠檬酸钠Sodium citrate 0.050.05
水解玉米淀粉Hydrolyzed corn starch 0.420.42
对羟基苯乙酮P-hydroxyacetophenone 0.400.40
椰油酰胺甲基MEACocamide methyl MEA 0.550.55
苯氧乙醇Phenoxyethanol 0.450.45
本发明所述的精油组合物(Ⅰ)Essential oil composition (Ⅰ) according to the present invention 0.200.20
制备方法：Preparation:
(1)按上述配方称取原料；(1) Weigh the raw materials according to the above formula;
(2)将上述去离子水、椰油酰水解燕麦蛋白钾、椰油酰谷氨酸二钠、聚季铵盐-10、水解玉米淀粉、椰油酰胺甲基MEA投入乳化锅加热到80℃，搅拌混合均匀，使其完全溶解；(2) Put the above-mentioned deionized water, cocoyl hydrolyzed potassium oat protein, disodium cocoyl glutamate, polyquaternium-10, hydrolyzed corn starch, cocoamide methyl MEA into the emulsifying pot and heat to 80 ℃ , Stir and mix to make it completely dissolved;
(3)降温到50℃加入本发明所述的精油组合物(Ⅰ)、对羟基苯乙酮、苯氧乙醇和柠檬酸-柠檬酸钠缓冲液将pH值调至5.0～7.0，搅拌均匀；(3) Reduce the temperature to 50 ° C and add the essential oil composition (I), p-hydroxyacetophenone, phenoxyethanol and citric acid-sodium citrate buffer to adjust the pH to 5.0-7.0, and stir evenly;
(4)抽真空，搅拌均匀，降温到37℃出料。(4) Vacuum, stir evenly, lower the temperature to 37 ℃ to discharge.
应用实施例3头皮护理护发素Application Example 3 Scalp Care Conditioner
一种含有所述的头皮护理用的精油组合物的头皮护理护发素，具体配方如表10所示：A scalp care conditioner containing the essential oil composition for scalp care is described in Table 10:
表10Table 10
物质名称Substance name 质量分数/％Quality score /%
二十二烷基三甲基氯化铵Behenyl trimethyl ammonium chloride 4.24.2
单硬脂酸甘油酯Glyceryl monostearate 2.12.1
聚二甲基硅氧烷Polydimethylsiloxane 3.23.2
十六十八醇Cetostearyl alcohol 3.43.4
乙二胺四乙酸二钠Disodium EDTA 0.050.05
本发明的精油组合物(Ⅰ)The essential oil composition of the present invention (Ⅰ) 10.010.0
对羟基苯乙酮P-hydroxyacetophenone 0.30.3
苯氧乙醇Phenoxyethanol 0.40.4
去离子水Deionized water 余量margin
制备方法：将二十二烷基三甲基氯化铵、乙二胺四乙酸二钠加入至去离子水中，加热至80℃，为水相。将单硬脂酸甘油酯、十六十八醇、聚二甲基硅氧烷混合，加热至80℃，为油相。将油相和水相加到乳化锅中，搅拌均匀，乳化均质5分钟后，搅拌冷却至50℃时，加入苯氧乙醇、对羟基苯乙酮和本发明的精油组合物(Ⅰ)，搅拌均匀，冷却至38℃，即为头皮护理护发素。Preparation method: Add behenyl trimethyl ammonium chloride and disodium ethylenediaminetetraacetic acid to deionized water and heat to 80 ° C to form an aqueous phase. Mix glyceryl monostearate, cetearyl alcohol, and polydimethylsiloxane, and heat to 80 ° C to form the oil phase. Add the oil phase and the water phase to the emulsifying pot, stir evenly, after emulsifying and homogenizing for 5 minutes, when stirring and cooling to 50 ° C, add phenoxyethanol, p-hydroxyacetophenone and the essential oil composition (Ⅰ) of the invention Stir well and cool to 38 ° C, which is a scalp care conditioner.
效果实施例1头皮效果评价Effect Example 1 Evaluation of scalp effect
评价样品：应用实施例1和应用对比例1制备的产品。Evaluation samples: the products prepared using Application Example 1 and Comparative Example 1.
评价方法：选取30名脂溢性脱发的受试者，均为男性，年龄在30～45岁，使用方法为每次洗头后，将样品喷于头皮上，按摩头皮5分钟。使用2个月后，从脱发改善度、头皮滋润度、头皮清爽度、头皮粉刺改善度、头发毛躁改善度五个方面进行评价。Evaluation method: 30 subjects with seborrheic alopecia were selected, all male, aged 30-45 years old. The method of application was to spray the sample on the scalp after each shampoo and massage the scalp for 5 minutes. After 2 months of use, the evaluation was made from five aspects: improvement in hair loss, scalp moisture, scalp refreshing, scalp acne improvement, and hair frizz improvement.
评价标准：1分-差，2分-较差，3分-一般，4分-较好，5分-很好。Evaluation criteria: 1 point-poor, 2 points-poor, 3 points-fair, 4 points-good, 5 points-very good.
评价结果：见表11所示。Evaluation results: see Table 11.
表11评价结果Table 11 Evaluation results
评价项目Evaluation project 应用实施例1Application Example 1 应用对比例1Application Comparative Example 1
脱发改善度Hair loss improvement 4.44.4 1.81.8
头皮滋润度Scalp moisture 4.64.6 3.43.4
头皮清爽度Scalp refreshing 4.74.7 2.82.8
头皮粉刺改善度Scalp improvement 4.34.3 3.23.2
改善头发毛躁度Improve hair frizz 4.84.8 3.53.5
由表11结果可知，应用实施例1产品脱发改善度、对头皮的滋润度、清爽度、头皮粉刺改善度和头发毛躁改善度都明显优于应用对比例1。说明添加有本发明的精油组合物可以滋润头皮，改善脱发，改善头发毛躁，改善头皮粉刺，同时不油腻，起到头皮护理的作用。It can be seen from the results in Table 11 that the hair loss improvement degree, moisturizing degree to the scalp, refreshing degree, scalp acne improvement degree and hair frizziness improvement of the product of Application Example 1 are significantly better than those of Application Comparative Example 1. It shows that adding the essential oil composition of the present invention can moisturize the scalp, improve hair loss, improve hair frizz, improve scalp acne, and at the same time, it is not greasy and plays the role of scalp care.
上述实施例为本发明较佳的实施方式，但本发明的实施方式并不受上述实施例的限制，其他的任何未背离本发明的精神实质与原理下所作的改变、修饰、替代、组合、简化，均应为等效的置换方式，都包含在本发明的保护范围之内。The above embodiments are preferred embodiments of the present invention, but the embodiments of the present invention are not limited by the above embodiments. Any other changes, modifications, substitutions, combinations, changes, modifications, substitutions, combinations, etc. that do not depart from the spirit and principles of the present invention The simplifications should all be equivalent replacement methods, which are all included in the protection scope of the present invention.

Claims (10)

  1. 一种头皮护理用精油组合物，其特征在于：由如下重量百分比的组分制成：姜精油0.05～10.0％；香茅精油0.1～5.0％；茶树精油0.05～6.0％；乳香精油0.1～6.0％；雪松精油0.1～6.0％；基础油为余量。An essential oil composition for scalp care, characterized by being made of the following components by weight: ginger essential oil 0.05-10.0%; citronella essential oil 0.1-5.0%; tea tree essential oil 0.05-6.0%; frankincense essential oil 0.1-6.0 %; Cedar essential oil 0.1 to 6.0%; base oil is the balance.
  2. 根据权利要求1所述的头皮护理用精油组合物，其特征在于：由如下重量百分比的组分制成：姜精油0.1～8.0％；香茅精油0.1～3.0％；茶树精油0.1～5.0％；乳香精油0.1～5.0％；雪松精油0.1～4.0％；基础油为余量。The essential oil composition for scalp care according to claim 1, which is made of the following components by weight: ginger essential oil 0.1-8.0%; citronella essential oil 0.1-3.0%; tea tree essential oil 0.1-5.0%; Frankincense essential oil 0.1-5.0%; Cedar essential oil 0.1-4.0%; Base oil is the balance.
  3. 根据权利要求1所述的头皮护理用精油组合物，其特征在于：由如下重量百分比的组分制成：姜精油1.1～2.0％；香茅精油0.5～0.6％；茶树精油0.7～0.8％；乳香精油0.9～1.3％；雪松精油0.8～1.3％；基础油为余量。The essential oil composition for scalp care according to claim 1, which is made of the following components by weight: ginger essential oil 1.1-2.0%; citronella essential oil 0.5-0.6%; tea tree essential oil 0.7-0.8%; Frankincense essential oil 0.9-1.3%; Cedar essential oil 0.8-1.3%; Base oil is the balance.
  4. 根据权利要求1～3任一项所述的头皮护理用精油组合物，其特征在于：The essential oil composition for scalp care according to any one of claims 1 to 3, characterized in that:
    所述的基础油为葡萄籽油、小麦胚芽油、橄榄油、霍霍巴油中的一种或多种的混合物。The base oil is a mixture of one or more of grape seed oil, wheat germ oil, olive oil, and jojoba oil.
  5. 权利要求1～4任一项所述的头皮护理用精油组合物在制备化妆品中的应用。Use of the essential oil composition for scalp care according to any one of claims 1 to 4 in the preparation of cosmetics.
  6. 根据权利要求5所述的应用，其特征在于：所述的头皮护理用精油组合物在化妆品中的添加量以质量分数计为0.1～50％。The use according to claim 5, characterized in that the amount of the essential oil composition for scalp care added to cosmetics is 0.1-50% in terms of mass fraction.
  7. 一种头皮护理用化妆品，其特征在于：含有权利要求1～4任一项所述的头皮护理用精油组合物。A cosmetic for scalp care, comprising the essential oil composition for scalp care according to any one of claims 1 to 4.
  8. 根据权利要求7所述的头皮护理用化妆品，其特征在于：The cosmetic for scalp care according to claim 7, characterized in that:
    所述化妆品含有以质量分数计为0.1～50％的头皮护理用精油组合物。The cosmetics contain an essential oil composition for scalp care in a mass fraction of 0.1 to 50%.
  9. 根据权利要求7或8所述的头皮护理用化妆品，其特征在于：所述的化妆品为：水剂、乳液类、膏霜类、喷雾类、精华类、精油类、皂类、洗护类。The cosmetic for scalp care according to claim 7 or 8, wherein the cosmetics are: liquids, lotions, creams, sprays, essences, essential oils, soaps, and care products.
  10. 根据权利要求7或8所述的头皮护理用化妆品，其特征在于：The cosmetic for scalp care according to claim 7 or 8, wherein:
    所述的头皮按摩精油，包括如下质量分数计的组分：The scalp massage essential oil includes components as follows:
    Figure PCTCN2018117883-appb-100001
    Figure PCTCN2018117883-appb-100001
    所述的头皮护理洗头水，包括如下质量分数计的组分：The scalp care shampoo includes the following components by mass fraction:
    Figure PCTCN2018117883-appb-100002
    Figure PCTCN2018117883-appb-100002
    所述的头皮护理护发素，包括如下质量分数计的组分：The scalp care conditioner includes components as follows:
    Figure PCTCN2018117883-appb-100003
    Figure PCTCN2018117883-appb-100003
PCT/CN2018/117883 2018-11-15 2018-11-28 Essential oil composition for scalp care and use WO2020097982A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201811361720.5A CN109381375B (en) 2018-11-15 2018-11-15 Essential oil composition for scalp care and application
CN201811361720.5 2018-11-15

Publications (1)

Publication Number Publication Date
WO2020097982A1 true WO2020097982A1 (en) 2020-05-22

Family

ID=65429309

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2018/117883 WO2020097982A1 (en) 2018-11-15 2018-11-28 Essential oil composition for scalp care and use

Country Status (2)

Country Link
CN (1) CN109381375B (en)
WO (1) WO2020097982A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110420154A (en) * 2019-08-29 2019-11-08 广东轻工职业技术学院 A kind of Anti-hair loss traditional Chinese medicine composition and the preparation method and application thereof
CN112675093A (en) * 2021-01-11 2021-04-20 广东成烨泰生物科技有限公司 Plant scalp care composition, scalp care solution and preparation method thereof

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104173240A (en) * 2014-08-28 2014-12-03 青岛永通电梯工程有限公司 Compound tea tree essential oil
CN105213224A (en) * 2015-09-22 2016-01-06 拉芳家化股份有限公司 A kind of Haircare composition of moisturizing
CN106580730A (en) * 2016-12-12 2017-04-26 广州环亚化妆品科技有限公司 Silicone oil-free transparent shampoo adopting cereal amino acid salts as surfactant, and production method thereof
CN106937922A (en) * 2017-05-23 2017-07-11 邓子坚 A kind of anti-acne compound essential oil
CN107519046A (en) * 2017-08-01 2017-12-29 深圳慧镁尔科技有限公司 A kind of anticreep strengthen the hair hair growth composition, preparation method and applications
CN107802551A (en) * 2017-12-08 2018-03-16 广州环亚化妆品科技有限公司 A kind of shampoo and preparation method thereof
CN108309836A (en) * 2018-04-27 2018-07-24 广州环亚化妆品科技有限公司 A kind of compound plant essential oil and its preparation method and application
CN108478504A (en) * 2018-05-03 2018-09-04 云南健牛生物科技有限公司 A kind of efficient sterilizing anticreep shampoo and preparation method thereof
CN108542805A (en) * 2018-04-26 2018-09-18 江西中医药大学 Anti-acne compound essential oil preparation and its preparation method and application

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101705157B (en) * 2009-11-17 2012-06-06 宁波旷世智源工艺设计股份有限公司 Aromatic candle with skin care effect and preparation method thereof
KR20140060093A (en) * 2012-11-09 2014-05-19 이영호 Shampoo compositions and preparation method thereof
CN104161705A (en) * 2014-08-21 2014-11-26 青岛蓝图文化传播有限公司市南分公司 Anti-dandruff compound essential oil
CN104288003A (en) * 2014-09-18 2015-01-21 青岛永通电梯工程有限公司 Hair care essential oil with effects of relieving itching and removing dandruff

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104173240A (en) * 2014-08-28 2014-12-03 青岛永通电梯工程有限公司 Compound tea tree essential oil
CN105213224A (en) * 2015-09-22 2016-01-06 拉芳家化股份有限公司 A kind of Haircare composition of moisturizing
CN106580730A (en) * 2016-12-12 2017-04-26 广州环亚化妆品科技有限公司 Silicone oil-free transparent shampoo adopting cereal amino acid salts as surfactant, and production method thereof
CN106937922A (en) * 2017-05-23 2017-07-11 邓子坚 A kind of anti-acne compound essential oil
CN107519046A (en) * 2017-08-01 2017-12-29 深圳慧镁尔科技有限公司 A kind of anticreep strengthen the hair hair growth composition, preparation method and applications
CN107802551A (en) * 2017-12-08 2018-03-16 广州环亚化妆品科技有限公司 A kind of shampoo and preparation method thereof
CN108542805A (en) * 2018-04-26 2018-09-18 江西中医药大学 Anti-acne compound essential oil preparation and its preparation method and application
CN108309836A (en) * 2018-04-27 2018-07-24 广州环亚化妆品科技有限公司 A kind of compound plant essential oil and its preparation method and application
CN108478504A (en) * 2018-05-03 2018-09-04 云南健牛生物科技有限公司 A kind of efficient sterilizing anticreep shampoo and preparation method thereof

Also Published As

Publication number Publication date
CN109381375B (en) 2021-06-04
CN109381375A (en) 2019-02-26

Similar Documents

Publication Publication Date Title
RU2537243C2 (en) Oral preparation, preparation for injections, skin preparation for external use and cosmetic method for wrinkle prevention or smoothing
CN109044915B (en) Infant hip-protecting cream and preparation process thereof
CN109350591B (en) Dry facial mask for beautifying face and preparation method thereof
CN109260059B (en) Essential oil composition with acne removing and skin repairing effects and application thereof
CN110755331B (en) Antibacterial infant washing and caring preparation and application thereof
CN108113894A (en) A kind of infant's activity milky lotion and preparation method thereof
CN114796024B (en) Bionic sebum composition for skin barrier repair, and preparation method and application thereof
CN106389139A (en) Acne-removing, mark-eliminating and skin-protecting multifunctional preparation and preparation method thereof
WO2020097982A1 (en) Essential oil composition for scalp care and use
CN110960463A (en) Shampoo composition containing hemp leaf extract composite preparation
CN108852900A (en) A kind of antibacterial facial mask and preparation method thereof containing tridecanoic peptide
CN1357321A (en) Inflammation and red spot reducing method
WO2012010022A1 (en) New use of hesperetin
CN103202796B (en) Skin care composition and face cream with acne treatment efficacy and preparation method of face cream
CN112773733A (en) Acne-removing composition and preparation method of emulsion thereof
CN109453098B (en) Soothing composition and preparation method and application thereof
CN115337351B (en) Traditional Chinese medicine compound essential oil
CN115429738A (en) Acne-removing repairing revitalizing essence and preparation method thereof
CN103211741B (en) Skincare composition and lotion with anti-acne effect, and preparation method of skincare composition
CN109330947A (en) A kind of oil control and acne removal toner and preparation method thereof
CN115969725A (en) Skin care composition for soothing and repairing sensitive muscles and preparation method and application thereof
CN108852944A (en) It is a kind of using OPC as tridecanoic peptide antibacterial repair latex of carrier and preparation method thereof
KR102115668B1 (en) Cosmetic composition having anti-acne activity comprising probiotics fermentation product
CN109330917B (en) Essential oil composition with whitening, anti-aging and moisturizing effects and application thereof
CN113693976A (en) Sericin stock solution shampoo and preparation method thereof

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18940020

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18940020

Country of ref document: EP

Kind code of ref document: A1