CN107319164A - A kind of complex compound of secondary Complexing Iron and its production and use - Google Patents
A kind of complex compound of secondary Complexing Iron and its production and use Download PDFInfo
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- CN107319164A CN107319164A CN201710723240.8A CN201710723240A CN107319164A CN 107319164 A CN107319164 A CN 107319164A CN 201710723240 A CN201710723240 A CN 201710723240A CN 107319164 A CN107319164 A CN 107319164A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
Abstract
The present invention relates to a kind of complex compound, particularly a kind of complex compound of secondary Complexing Iron, preparation method and its purposes in animal feed additive.A kind of complex compound of secondary Complexing Iron, first by sucrose Complexing Iron, then again with the ferrous ion in amino-acid complex waste liquid and filter residue, it is ensured that iron reaction is complete, finally again by sucrose iron product and the ferrous product mix of amino-acid complex.The complex compound of the secondary Complexing Iron of the present invention had both possessed sucrose Complexing Iron low cost, growth promoting function clear advantage, but also with the ferrous biological value height of amino-acid complex, the advantage that chemical property is stable, palatability is good, with merely with amino-acid complex (chelating) compared with micro- used cost, present invention reduces 30 40% use cost.
Description
Technical field
The present invention relates to a kind of complex compound, particularly a kind of complex compound of secondary Complexing Iron, preparation method and its in animal
Purposes in feed addictive.
Background technology
The nutritive physiology function of iron:1st, as the component of carrier and enzyme：Iron take part in the group of hemoglobin and myoglobins
Into being responsible for the important function of oxygen and carbon dioxide in carrier.In addition, iron directly participates in cytochrome oxidase, peroxidating
The composition of thing enzyme and xanthine oxidase etc..Divalence or ferric ion again be activate carbohydrate metabolism various enzymes not
The activation factor that can lack；2nd, protein synthesis and energetic supersession are participated in：The content of iron directly affects the content of phosphorus in animal body,
The synthesis of DNA during iron deficiency in liver cell can be suppressed because lacking phosphorus, and the mitochondria and microsome in histocyte are abnormal.This
Outside, iron participates in the energy metabolism in zooblast as the component of cytochromes.Romslo thinks the release of energy i (in vivo)
The quantity that mitochondria assembles iron is depended on, and both are directly proportional；3rd, physiology defence and immunity function：Newborn iron in leucocyte or milk
The iron ion dissociated in enteron aisle can be combined into compound by albumen, in order to the utilization of Bacillus acidi lactici, while inhibiting large intestine
The effect of bacillus, can prevent the diarrhoea of new born animal especially piglet well.
Asiderosis can cause with excessive：1st, anaemia：This is the most notable symptom of animal iron deficiency.Iron can influence vivo protein
The synthesis of matter, during iron deficiency, the mitochondria and microsome in liver cell and other histocytes are abnormal, and cromoci content declines,
Protein is synthesized and energy utilization is obstructed, and anaemia, Body weight loss occurs in animal.The explanation of another mechanism of action is：After iron deficiency,
The DNA synthesis of lymphocyte is disturbed, and loses the sensitiveness to specific antigen, and the stress ability of body fight infections declines, easily
Infected, the destruction of red blood cell accelerates after infection, causes animal anaemia；2nd, oxidation-reduction process is disorderly, lesion occurs：Research card
It is bright, there is the enzyme of more than half to contain iron, or the competence exertion biochemical action in the presence of iron in tricarboxylic acid cycle.Iron deficiency can cause this
The activity of a little enzymes is severely impacted, so as to influence the transport and storage of internal oxygen.In addition, ferrous sulfide compound is proved
Critical effect is all played in many redox reactions of biosystem.Iron insufficient supply, respiratory chain and peroxide
Oxidation-reduction process can get muddled, and influence the eubolism of body；3rd, immunologic function is reduced：Immunologic function is reduced, and is added
Bacterium and the sensitiveness of parasitic infection, so that body weight and growing for body length are adversely affected.The abdomen of such as piglet
Rush down and the high death rate；4th, iron poisoning：Normal addition chalybeate amount is generally below 0.014% in pig perfect compound feed, and broiler chicken is just
Normal addition is 0.008%, and laying hen is 0.005%, if more than 20 times of the addition amount of being above standard just occurs in chronic iron
Malicious phenomenon.The dosis tolerata of iron is generally large.The dosis tolerata 3000mg of iron in pig feeding daily ration, ox and fowl are 1000mg.But addition
Excessively, poisoning is easily caused.The toxic dose of 3-10 age in days Piglet by Oral ferrous sulfate is：600mg body weight, 1-3h may occur in which after feeding
Poisoning symptom.In addition, intravenous injection molysite is more much bigger than oral toxicity.It can also draw after shot high dose iron preparation, 3-5h
Play piglet poisoning.Hu Xingui (1999) is reported, gives piggy injection chalybeate 200ml, that is, is mended iron and reached 450-750mg, in occurring as soon as
Toxication shape.Flush is shown as, dull mind, astasia is short of breath, and hypothermia is drowsiness, then goes into a coma, seriously
When it is dead.
Application of the iron additive on animal productiong：The iron additive used in current feed experienced three development ranks
Section, first generation product is inorganic iron：Ferrous sulfate, ferrous carbonate, ferric oxide, iron chloride, frerrous chloride etc.；Second generation product
That is organic salt iron：Ferric lactate, ferrodextranum, ferrous citrate, fumaric acid iron etc.；The third generation is protein sources or chelating amino acids
Iron：Ferrous methionine chelate, threonine chelated iron etc..Inorganic iron：Ferrous sulfate is good inorganic source of iron, especially seven water sulphur
Sour ferrous salt is most widely used in current feed industry.Japanese scholars (1993) research shows, in the food stuff for chicken laying of laying period
Middle mix 100mg FeSO4Powder feed, can prevent the hypoferric anemia of hen, and then improve laying rate more than 25%.Due to
Ferrous sulfate dissolubility is good and can be as effective heme moiety, so being often used in mending iron to piglet, typically, for prevention son
Blows or bacterial infection toxin, it is ensured that normal growth, 2-3 ages in days should just mend iron.The mode of supplement chalybeate has directly to piglet
Mend and iron and mend two kinds of iron indirectly by parent, such as, with ferrous sulfate 200mg iron supply sow, containing for iron in pig manure can be improved
Amount, makes piglet eat sow excrement 50-80g daily, can obtain the iron of prevention anaemia enough.
Organic Iron：The organic salt such as ferrodextranum, ferrous citrate, ferric lactate dissolubility is good, it is easy absorb, biological value compared with
High, stability is also high compared with inorganic salts.Organic salt iron is main in Production of Livestock and Poultry to be played nutrition and is immunized.(1) in terms of nutrition：
Organic Iron, organic cobalt and vitamin optimum organization, mend iron effect substantially rapid.The reproductive performance of sow can be improved, improves young
Pig survival rate, birth weight.Can improve egg fowl lay eggs quality, reduce shell-breaking rate, deepen yolk color, reduce stress.(2) it is immunized
Aspect：Piglet anaemia is effectively prevented, suppresses cub diarrhoea, piglet white scour.
Amino acid chelated iron：Amino acid chelated iron is a kind of ligand (amino acid) same metal ion species (trace element)
A kind of complex compound of the cyclic structure formed.Common chelate ring has five-membered ring and hexatomic ring, and wherein a-amino acid chelated iron is
Five-membered ring, beta-amino acids chelated iron is hexatomic ring.Trace element after chelating amino acids, is generated the moderate chelating of stability constant
Thing, these chelates utilize Amino Acid Absorption passage in small intestine, it is to avoid operated with passing through mineral element Ions Absorption passage
Other mineral elements competition and antagonism.The biochemical property of other chelate is more stablized, and effectively resists other in daily ration and supports
Divide and adverse effect occurs therewith.Chelate solubility property in body is good, it is easy absorb, utilization rate it is high.In addition, amino acid chelated iron
Also there is certain sterilization and immunologic function.It is believed that, chelated microelements are in particular organization, target organ or functional site
Play specific function.
At present, iron is added in internal feed still based on inorganic iron (ferrous sulfate).Its cost is low, and processing technology is simple,
Wide material sources, and the growth to livestock and poultry, breeding, production, immune etc. have preferable facilitation.But the iron ion in inorganic iron
Easily with other mineral ion antagonisms, compete, cause utilization rate to decline, food consumption increase can not increasingly meet modern production
Demand.Organic acid iron is better than inorganic iron stability, and biological value is high, and growth promoting function substantially, but still can not solve mineral element
Antagonism and race problem between ion.The appearance of amino acid chelated iron, effectively alleviates this interionic interaction.
Current biological value highest is amino acid chelated iron, and it has following particular advantages：1. in terms of nutrition：1st, it is biological
Potency highest, stability are good；2nd, the antagonism between mineral element is effectively alleviated；3rd, it is not only that body provides trace element, and
Also provide essential amino acid；4th, palatability is good, it is to avoid unnecessary waste.2. process aspect：Ammonia in amino acid chelated iron
Base acid derives from the enzymolysis of protein sources.For example some puffed soybeans of current many protein sources, keratoprotein, industrial waste, Industry Waste
Slag, liquid, quantity are big, are but difficult by, cause the very big wasting of resources.These protein sources digest the cheap amino of the high-quality produced
Acid is used for producing amino acid chelated iron, kills two birds with one stone.
However, micro- with the amino-acid complex (chelating) of the synthesis such as the higher lysine of price, methionine, glycine
Although biological value is higher, its use cost is also of a relatively high, especially under current feed market environment with keen competition, drop
The demand of low use cost is increasingly highlighted.
Therefore, inventor uses sucrose Complexing Iron, the iron then not reacted completely with amino-acid complex again, both reduces into
This, moreover it is possible to keep certain biological value.
The information for being disclosed in the background section is merely intended to understanding of the increase to the general background of the present invention, without answering
When the prior art for being considered as recognizing or implying the information structure in any form well known to persons skilled in the art.
The content of the invention
For deficiencies of the prior art, the present invention provides one kind and had both possessed sucrose Complexing Iron low cost, growth-promoting
Long effect clear advantage is high, the advantage that chemical property is stable, palatability is good but also with the ferrous biological value of amino-acid complex
Complex compound of secondary Complexing Iron and preparation method thereof.
To achieve the above object, the technical scheme that the present invention is provided is as follows：
A kind of complex compound of secondary Complexing Iron, it includes iron sucrose and amino acid-ferrous；
The iron sucrose is made up of sucrose and soluble ferrous salt of complex reaction；
The amino acid-ferrous ferrous salt by amino acid and solubility is made up of complex reaction.
Preferably, described soluble ferrous salt is any in ferrous sulfate heptahydrate, frerrous chloride, ferrous carbonate
Kind.
Preferably, the amino acid is any of methionine, cystine, glycine.
Present invention also offers the preparation method of the complex compound of described secondary Complexing Iron, comprise the following steps：
Take the raw material of following parts by weight：25-32 parts of sucrose, 50-65 parts of water, 30-35 parts of soluble ferrous salt, amino acid
5-20 parts, it is prepared from according to the following steps：
(1) after the sucrose water in reactor is dissolved, soluble ferrous salt is added, pH value is adjusted to 11-12；
(2) heating response device is to reactor temperature after 80 DEG C of device Nei Wenduda, is kept at 70-80 DEG C, and lasting stirring is anti-
1-2h is answered, iron sucrose solution is made；
(3) cooling iron sucrose solution is separated by filtration to normal temperature, obtains the first separating liquid and the first sediment, the first separation
Liquid adds the sedimentation of 75% ethanol solution, obtains the second separating liquid and the second sediment, and the second sediment centrifugation suction filtration is dried, sieved
Divide, detect, iron sucrose is made；
(4) the second separating liquid is evaporated, ethanol is reclaimed, while the 3rd separating liquid is obtained, by the 3rd separating liquid and step (3) institute
Obtain after the mixing of the first sediment, the ferrous ion concentration in detection mixture, add amino acid, tune pH value is 6-7；
(5) stirring reaction 60-70min is continued, it is ferrous that amino-acid complex is made in concentration, dry, crushing, screening；
(6) gained iron sucrose is mixed with amino-acid complex ferrous iron, that is, the complex compound of secondary Complexing Iron is made.
Preferably, the mass ratio of first separating liquid and 75% ethanol solution is 1: 2.
Preferably, first separating liquid can return to the mother liquor as dissolving saccharose, circulation step (1)~(3).
Preferably, in the step (3), drying as vacuum drying.
Preferably, in the step (4), the mol ratio of amino acid and ferrous ion is 2:1.
Preferably, in the step (6), iron sucrose and amino-acid complex ferrous iron 2-5 in mass ratio:1-3 is mixed.
Present invention also offers purposes of the complex compound of described secondary Complexing Iron as animal feed additive, itself and feeding
Feeding animals after material mixing.
Further, the addition of animal feed additive is 200g/ tons of feeds.
There are a pair of lone pair electrons on the glycosidic bond of sucrose (few disaccharides), while transition metal ions (M=Cu2+、Zn2+、Mn2 +、Fe2+、Ca2+) there is suitable unoccupied orbital, can be with sucrose formation " coordination effect ", after chemical reaction under suitable temperature environment
Complexing forms complex state metal, is absorbed beneficial to animal body.It is as follows that it forms molecular structural formula：
Above-mentioned figure is the micro- molecular structural formula of sucrose, wherein M=Cu2+、Zn2+、Mn2+、Fe2+、Ca2+。
Because the reaction of sucrose trace-element complex is complicated, product is different from general amino-acid chelate, many category
In macromolecular structure, the molecular weight not determined.
Inventor makes full use of waste water evaporation to reclaim after ethanol remaining waste liquid and be separated by filtration the mixing of obtained filter residue
Thing, secondary complex reaction is carried out with amino acid by the ferrous ion in the mixture, generates the moderate complex compound of stability constant, this
A little complex compounds utilize Amino Acid Absorption passage in small intestine, it is to avoid with operated by mineral element Ions Absorption passage other
The competition of mineral element and antagonism.The biochemical property of other complex compound is more stablized, and effectively resists the nutrient of other in daily ration therewith
Generation adverse effect.Complex compound solubility property in body is good, it is easy absorb, utilization rate it is high.In addition, amino-acid complex ferrous iron also has
There are certain sterilization and immunologic function.
At present, the complex products of most of amino acid and trace element are all by 1 with amino acid with trace element both at home and abroad:
1 mol ratio is come the product being complexed, and what is obtained is the not neutral complex compound of electricity.The not neutral complex ion of electricity is absorbed into by animal
Enter before cell, can be by other anion, such as PO in substrate in animal body4 3-、SO4 2-、CO3 2-Etc. the suction of many negatively charged ions
Draw, interception is combined into ionic bond, so as to stop that complex ion smoothly absorbs and utilized.Because 1:The complex compound of 1 mol ratio only has
One complexing ring, so bioactivity is also than 2:1 mol ratio it is low, the amount that causes complex compound to be absorbed by animal is not uncertain, not yet
It is stable.And step 2 of the present invention) described in amino-acid complex it is ferrous, amino acid and the ferrous ion mol ratio of complex reaction are
2：1, step 2) obtained product is organic complex, complete electroneutral.
The application method of complex compound of the secondary Complexing Iron of the present invention is：After being well mixed with feed, for pig, chicken, duck,
Ox and the feeding of sheep, addition are 200g/ tons of feeds.
Compared with prior art, the present invention has the advantages that：
(1) complex compound of secondary Complexing Iron of the invention, it is then useless with amino-acid complex again first by sucrose Complexing Iron
Ferrous ion in liquid and filter residue, it is ensured that iron reaction is complete, finally again mixes the ferrous product of sucrose iron product and amino-acid complex
Close.The mixture had both possessed sucrose Complexing Iron low cost, growth promoting function clear advantage, biological but also with iron-amino acid complex
The advantage that potency is high, chemical property is stable, palatability is good, with it is simple with amino-acid complex (chelating) trace element it is used into
Originally compare, present invention reduces 30-40% use cost.
(2) complex compound of secondary Complexing Iron of the invention, iron sucrose dissolubility therein is good, it is easy absorb, stability it is good, make
For feed addictive, the excrement excretion of feed source trace element can be substantially reduced, pollution of the aquaculture to environment is reduced, moreover it is possible to change
Kind meat is yellowish pink, strengthens the anti-oxidation function of body, significantly improves the vigor of the GSH-Px in liver, muscle, improve serum T-
AOC and T-SOD, reduces UN, significantly improves the Nutrient Apparent Digestibilities such as feed CP, EE, calcium, phosphorus, increases the deposition of nitrogen, moreover it is possible to aobvious
Write and improve serum levels of iron and liver iron content.Iron sucrose can also effectively prevent piglet anaemia in immunology, suppress cub diarrhoea,
Piglet white scour.Iron sucrose is in terms of nutrition, and vitamin optimum organization, mend iron effect it is substantially rapid, it is possible to increase sow it is numerous
Grow performance, improve piglet survival rate, birth weight, can improve egg fowl lay eggs quality, reduce shell-breaking rate, deepen yolk color, subtract
Less stress.
(3) complex compound of secondary Complexing Iron of the invention, amino-acid complex ferrous iron therein can effectively alleviate mineral element
Between antagonism, only body does not provide trace elements iron, and also provides essential amino acid, and palatability is good, it is to avoid need not
The waste wanted.Amino-acid complex ferrous iron utilizes Amino Acid Absorption passage in small intestine, it is to avoid with being inhaled by mineral element ion
Receive competition and the antagonism of other mineral elements of passage operating.The biochemical property of the other complex compound is more stablized, and effectively resists
Adverse effect occurs therewith for the nutrient of other in daily ration.Complex compound solubility property in body is good, it is easy absorb, utilization rate it is high.In addition,
Amino-acid complex is ferrous also to have certain sterilization and immunologic function.
(4) complex compound of secondary Complexing Iron of the invention, organic trace element amount ratio inorganic ions is few, and absorbs profit
3-4 times is higher by with rate, waste is not resulted in, while problem of environmental pollution is improved, the security to people is improved.
(5) complex compound of secondary Complexing Iron of the invention is compared with inorganic iron, and trap is high, with high content of technology, and effect is high,
Growth promoting gaining effect is good, lower than use cost with amino acid iron phase, significantly improves the core competitiveness of product.
Embodiment
With reference to specific embodiment, the embodiment to the present invention is described in detail, it is to be understood that this hair
Bright protection domain is not limited by embodiment.
Embodiment 1：
A kind of complex compound of secondary Complexing Iron, it is made up of sucrose, soluble ferrite and amino acid.
The preparation method of the complex compound of described secondary Complexing Iron, comprises the following steps：
(1) toward in reactor plus 25 parts by weight sucrose, plus after the water dissolving saccharose of 50 parts by weight, add 30 parts by weight
Ferrous sulfate heptahydrate, hydrogenation aqueous solution of sodium oxide alkalization, the pH of regulation solution is 11, and heating response kettle keeps temperature in the kettle to exist
Between 70-80 DEG C, complex reaction 1h is carried out, course of reaction is stirred continuously, generate iron sucrose solution, be separated by filtration, obtain filter residue A
And filtrate a, 75% ethanol solution that 2 times of parts by weight are added in filtrate a is precipitated, the completely rear centrifugation suction filtration of precipitation is obtained
Filter residue B and filtrate b, filter residue B vacuum drying drying, screening, detection obtain iron sucrose product；Described filtrate can return to work
For the mother liquor of dissolving saccharose, the reaction of above-mentioned generation iron sucrose is recyclable to be carried out；
(2) step (1) is centrifuged into filtered filtrate b evaporations and reclaims ethanol, and obtain extraction raffinate c, by extraction raffinate c and filter residue A
Mixing, obtains mixture, detects mixture ferrous ions concentration, is then 2 by amino acid and ferrous ion:1 mol ratio
Methionine is added, is 6 with the pH of sodium hydrate aqueous solution regulation system, reaction temperature is controlled at 70 DEG C, carries out complex reaction, instead
Answer time control in 60min, after reaction terminates, concentrate, dry, then crushed with pulverizer, then sieved, detection is
Obtain amino-acid complex ferrous；
(3) by sucrose iron product and the ferrous product in mass ratio 5 of amino-acid complex:3 are mixed, that is, obtain secondary complexing
The complex compound of iron.
Embodiment 2：
A kind of complex compound of secondary Complexing Iron, it is made up of sucrose, soluble ferrite and amino acid.
The preparation method of the complex compound of described secondary Complexing Iron, comprises the following steps：
(1) toward in reactor plus 32 parts by weight sucrose, plus after the water dissolving saccharose of 65 parts by weight, add 11 parts by weight chlorine
Change ferrous, hydrogenation aqueous solution of sodium oxide alkalization, the pH of regulation solution is 12, heating response kettle keeps temperature in the kettle at 70-80 DEG C
Between, complex reaction 2h is carried out, course of reaction is stirred continuously, generate iron sucrose solution, be separated by filtration, obtain filter residue A and filtrate
A, by filtrate a add 2 times of parts by weight 75% ethanol solution precipitated, precipitation completely after centrifuge suction filtration, obtain filter residue B and
Filtrate b, filter residue B vacuum drying drying, screening, detection obtain iron sucrose product；Described filtrate can return to as dissolving sugarcane
The mother liquor of sugar, the reaction of above-mentioned generation iron sucrose is recyclable to be carried out；
(2) step (1) is centrifuged into filtered filtrate b evaporations and reclaims ethanol, and obtain extraction raffinate c, by extraction raffinate c and filter residue A
Mixing, obtains mixture, detects mixture ferrous ions concentration, is then 2 by amino acid and ferrous ion:1 mol ratio
Cystine is added, is 7 with the pH of sodium hydrate aqueous solution regulation system, reaction temperature is controlled at 80 DEG C, carries out complex reaction, instead
Answer time control in 70min, after reaction terminates, concentrate, dry, then crushed with pulverizer, then sieved, detection is
Obtain amino-acid complex ferrous；
(3) by sucrose iron product and the ferrous product in mass ratio 2 of amino-acid complex:1 is mixed, that is, obtains secondary complexing
The complex compound of iron.
Embodiment 3：
A kind of complex compound of secondary Complexing Iron, it is made up of sucrose, soluble ferrous salt and amino acid.
The preparation method of the complex compound of described secondary Complexing Iron, comprises the following steps：
(1) toward in reactor plus 30 parts by weight sucrose, plus after the water dissolving saccharose of 55 parts by weight, add 33 parts by weight carbon
It is sour ferrous, hydrogenation aqueous solution of sodium oxide alkalization, the pH of regulation solution is 11, and heating response kettle keeps temperature in the kettle at 70-80 DEG C
Between, complex reaction 1.5h is carried out, course of reaction is stirred continuously, generate iron sucrose solution, be separated by filtration, obtain filter residue A and filter
Liquid a, 75% ethanol solution that 2 times of parts by weight are added in filtrate a is precipitated, the completely rear centrifugation suction filtration of precipitation, obtains filter residue B
And filtrate b, filter residue B vacuum drying drying, screening, detection, that is, obtain iron sucrose product；Described filtrate can return to as dissolving
The mother liquor of sucrose, the reaction of above-mentioned generation iron sucrose is recyclable to be carried out；
(2) step (1) is centrifuged into filtered filtrate b evaporations and reclaims ethanol, and obtain extraction raffinate c, by extraction raffinate c and filter residue A
Mixing, obtains mixture, detects mixture ferrous ions concentration, is then 2 by amino acid and ferrous ion:1 mol ratio
Glycine is added, is 6.5 with the pH of sodium hydrate aqueous solution regulation system, reaction temperature is controlled at 75 DEG C, carries out complex reaction,
Reaction time control is in 65min, after reaction terminates, and concentrates, dries, then is crushed with pulverizer, is then sieved, detected
Obtain amino-acid complex ferrous；
(3) by sucrose iron product and the ferrous product in mass ratio 1 of amino-acid complex:1 is mixed, that is, obtains secondary complexing
The complex compound of iron.
Embodiment 4：The application effect of the complex compound of the secondary Complexing Iron of the present invention
4.1 experiments are divided to two groups：The complex compound for the secondary Complexing Iron that test group is used is method system in 1-3 of the embodiment of the present invention
For what is gone out；The inorganic ferrous sulfate that control group is used is that commercial sulfuric acid is ferrous.
4.2 experimental animal：Sow and piglet.
4.3 experimental designs (are shown in Table 1).
The iron added in the feed of table 1 in the complex compound and ferrous sulfate of secondary Complexing Iron
4.4 feeding management：Nursery house uses slatted floor child care equipment, and house temperature control system is in 22-25 DEG C, relative humidity control
In 65-75%.Experiment the last week is cleaned, washed away and sterilized to pig house and various feeding utensils, is sprayed ground with caustic soda, is enclosed
The facilities such as column, trough, keep colony house ventilation, cleaning, dry during experiment.
4.5 testing index：Daily gain, feed efficiency, feedstuff-meat ratio, the feed intake in each cycle etc..
4.6 result of the test
(1) add respectively in the diet of the latter half of gestation of sow and whole lactation period (farrowing first 7 days to lactation the 26th day)
Plus the complex compound and ferrous sulfate of secondary Complexing Iron, test obtained result such as table 2.
Add secondary in the diet of the latter half of gestation of the sow of table 2 and whole lactation period (farrowing first 7 days to lactation the 26th day)
The complex compound and ferrous sulfate of Complexing Iron
| Project | Secondary complexing iron complex group | Ferrous sulfate group |
| Sow head number/head | 50 | 50 |
| Gestational period feed intake/pound | 510±6.2 | 516±5.3 |
| Lactation period feed intake/pound | 252±14.6 | 257±13.7 |
| Lactation period/day | 17.6±0.5 | 17.8±0.5 |
| Sow lactation period weightlessness/pound | 9.9±4.3 | 9.4±4.2 |
| Nest litter size/head | 10.4±0.5 | 10.1±0.4 |
| The number of live birth/head | 9.9±0.5 | 9.7±0.5 |
(2) 50 sows are divided into two groups, add secondary complexing iron complex and ferrous sulfate respectively in diet, iron adds
Dosage is 50mg/kg.30 days are observed after the sow gestation phase to the 20th day lactation period piglet death rate and nest number pigs weaned, knot
Fruit such as table 3.
Secondary complexing iron complex and the ferrous sulfate piglet death rate and nest number pigs weaned are added in the diet of table 3 respectively
| Project | Nest number pigs weaned/head | The death rate/% |
| Experimental group | 9.6 | 1.32 |
| Control group | 9.1 | 2.41 |
As shown in Table 3, test group and the nest number pigs weaned difference of control group are little, but add secondary Complexing Iron complexing
The piglet death rate of the experimental group of thing is substantially reduced, lower than control group by 45.22%.
(3) 50 close weanling pigs of body weight are randomly assigned into two groups, one group add secondary Complexing Iron complex compound (iron
Addition 100mg/kg), one group adds ferrous sulfate (iron addition is 100mg/kg).
Table 4 adds the production performance of the weanling pig of secondary complexing iron complex group
| Project | Experimental group | Control group |
| Number pigs weaned/head | 25 | 25 |
| Starting weight/kg | 17.67±3.22 | 17.71±3.41 |
| End weight/kg | 55.18±4.52 | 55.32±5.21 |
| Weightening/kg | 37.45±1.21 | 37.76±1.52 |
| Daily gain/g | 601±36.51 | 596±25.68 |
| Total augment weight/kg | 654.6 | 646.7 |
| Total feed consumption weight/kg | 1720.23 | 1782.59 |
| Feed-weight ratio | 2.57 | 2.71 |
As shown in Table 4, the daily gain of experimental group is slightly above control group, but then difference is somewhat big for feed-weight ratio.
(4) 50 close weanling pigs of body weight and sow are randomly assigned into two groups respectively, one group adds secondary Complexing Iron
Complex compound (iron addition 100mg/kg), one group adds ferrous sulfate (iron addition be 100mg/kg), detection pig it is blood red
Protein concentration, red blood cell number and ferro concentration in serum.
The complexing iron complexs of table 5 two times to sow hemoglobin concentration, red blood cell number, ferro concentration in serum influence
As can be seen from Table 5, the hemoglobin of experimental group, red blood cell number are higher all than control group, and two groups are present significantly
Difference；When 21 age in days, experimental group Iron in Serum content is higher than control group, it is seen then that secondary Complexing Iron of the invention
Complex compound is more conducive to the growth performance that sow improves sow.
The complexing iron complexs of table 6 two times to piglet hemoglobin concentration, red blood cell number, ferro concentration in serum influence
As shown in Table 6,7 age in days piglets of experimental group and hemoglobin, red blood cell number and the serum levels of iron of 21 age in days piglets contain
Amount is above control group.
In summary, the complex compound of the secondary Complexing Iron of the present invention is added in the diet of in-pig to be effectively reduced
It is born the death rate of piglet and weanling pig, is improved piglet weightening, reduces the death rate, increase weanling pig head number, reduce and adopt
Appetite, the effect for shortening lactation period；The complex compound of secondary Complexing Iron is added in weanling pig, then can reduce the material meat of piglet
Than improving the growth performance of piglet.
It is foregoing to the present invention specific illustrative embodiment description be in order to illustrate and illustration purpose.These descriptions
It is not wishing to limit the invention to disclosed precise forms, and it will be apparent that according to above-mentioned teaching, can be much changed
And change.The purpose of selecting and describing the exemplary embodiment is that explaining that the certain principles and its reality of the present invention should
With so that those skilled in the art can realize and using the present invention a variety of exemplaries and
A variety of selections and change.The scope of the present invention is intended to be limited by claims and its equivalents.
Claims (10)
1. a kind of complex compound of secondary Complexing Iron, it is characterised in that including iron sucrose and amino acid-ferrous；
The iron sucrose is made up of sucrose and soluble ferrous salt of complex reaction；
The amino acid-ferrous ferrous salt by amino acid and solubility is made up of complex reaction.
2. the complex compound of secondary iron according to claim 1, it is characterised in that described soluble ferrous salt is seven water
Any of ferrous sulfate, frerrous chloride, ferrous carbonate.
3. the complex compound of secondary iron according to claim 1, it is characterised in that the amino acid be methionine, cystine,
Any of glycine.
4. the preparation method of the complex compound of secondary Complexing Iron according to claim 1, it is characterised in that take following parts by weight
Raw material：25-32 parts of sucrose, 50-65 parts of water, 30-35 parts of soluble ferrous salt, 5-20 parts of amino acid is made according to the following steps
It is standby to form：
(1) after the sucrose water in reactor is dissolved, soluble ferrous salt is added, pH value is adjusted to 11-12；
(2) heating response device continues stirring reaction 1- to after 80 DEG C of device Nei Wenduda, keeping reactor temperature at 70-80 DEG C
2h, is made iron sucrose solution；
(3) cooling iron sucrose solution is separated by filtration to normal temperature, obtains the first separating liquid and the first sediment, the first separating liquid adds
Enter the sedimentation of 75% ethanol solution, obtain the second separating liquid and the second sediment, the second sediment centrifugation suction filtration is dried, sieves, examined
Survey, iron sucrose is made；
(4) the second separating liquid is evaporated, ethanol is reclaimed, while obtain the 3rd separating liquid, by obtained by the 3rd separating liquid and step (3) the
After the mixing of one sediment, the ferrous ion concentration in detection mixture adds amino acid, and tune pH value is 6-7；
(5) stirring reaction 60-70min is continued, it is ferrous that amino-acid complex is made in concentration, dry, crushing, screening；
(6) gained iron sucrose is mixed with amino-acid complex ferrous iron, that is, the complex compound of secondary Complexing Iron is made.
5. the preparation method of the complex compound of secondary Complexing Iron according to claim 4, it is characterised in that first separation
The mass ratio of liquid and 75% ethanol solution is 1: 2.
6. the preparation method of the complex compound of secondary Complexing Iron according to claim 4, it is characterised in that first separation
Liquid can return to the mother liquor as dissolving saccharose, circulation step (1)~(3).
7. the preparation method of the complex compound of secondary Complexing Iron according to claim 4, it is characterised in that the step (4)
In, the mol ratio of amino acid and ferrous ion is 2:1.
8. the preparation method of the complex compound of secondary Complexing Iron according to claim 4, it is characterised in that iron sucrose and amino
Acid complexing ferrous iron 2-5 in mass ratio:1-3 is mixed.
9. the complex compound purposes of secondary Complexing Iron according to claim 1, it is characterised in that added as animal feed
Agent, feeding animals after being mixed with feed.
10. the complex compound purposes of secondary Complexing Iron according to claim 9, it is characterised in that animal feed additive
Addition is 200g/ tons of feeds.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107712357A (en) * | 2017-11-21 | 2018-02-23 | 天峨县宏昌农机专业合作社 | A kind of complex compound of secondary Complexing Iron and preparation method thereof |
| CN107751577A (en) * | 2017-11-21 | 2018-03-06 | 天峨县宏昌农机专业合作社 | A kind of complex compound of secondary complexing zinc and application thereof |
| CN107873969A (en) * | 2017-11-21 | 2018-04-06 | 天峨县宏昌农机专业合作社 | A kind of complex compound of secondary complexing calcium |
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| CN102626180A (en) * | 2012-04-10 | 2012-08-08 | 南宁市泽威尔饲料有限责任公司 | Amino acid chelating compound organic feed additive and production method thereof |
| CN106243162A (en) * | 2016-08-01 | 2016-12-21 | 南宁市泽威尔饲料有限责任公司 | The preparation method of sucrose complex |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102626180A (en) * | 2012-04-10 | 2012-08-08 | 南宁市泽威尔饲料有限责任公司 | Amino acid chelating compound organic feed additive and production method thereof |
| CN106243162A (en) * | 2016-08-01 | 2016-12-21 | 南宁市泽威尔饲料有限责任公司 | The preparation method of sucrose complex |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107712357A (en) * | 2017-11-21 | 2018-02-23 | 天峨县宏昌农机专业合作社 | A kind of complex compound of secondary Complexing Iron and preparation method thereof |
| CN107751577A (en) * | 2017-11-21 | 2018-03-06 | 天峨县宏昌农机专业合作社 | A kind of complex compound of secondary complexing zinc and application thereof |
| CN107873969A (en) * | 2017-11-21 | 2018-04-06 | 天峨县宏昌农机专业合作社 | A kind of complex compound of secondary complexing calcium |
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Application publication date: 20171107 |