CN106188200B - The preparation method of sucrose zinc complex - Google Patents
The preparation method of sucrose zinc complex Download PDFInfo
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- CN106188200B CN106188200B CN201610613957.2A CN201610613957A CN106188200B CN 106188200 B CN106188200 B CN 106188200B CN 201610613957 A CN201610613957 A CN 201610613957A CN 106188200 B CN106188200 B CN 106188200B
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
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- C—CHEMISTRY; METALLURGY
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
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Abstract
The invention discloses a kind of preparation methods of sucrose zinc complex, it is by sucrose and white vitriol complex reaction, obtain sucrose zinc solution, then it filters after cooling, filter residue and filtrate are obtained, filtrate is added ethanol water and is settled out complex compound, and precipitating centrifugation is filtered, vacuum drying drying obtains purer sucrose complexing zinc product；The zinc ion concentration for detecting filter residue is 1:4 according to the molar ratio of sucrose and zinc ion, continuously adds sucrose and white vitriol, will be centrifuged filtered waste water back to the mother liquor in reaction kettle as dissolving saccharose, circular response continues generation sucrose zinc.The present invention prepares the process of sucrose zinc, not waste of resource, reduces production cost, improves production efficiency.Sucrose zinc is obtained with safe and efficient, high performance-price ratio advantage, can be applied to be suitble to the production comprehensive animal feed of nutrition.
Description
Technical field
The present invention relates to a kind of complex compounds, especially sucrose zinc complex and preparation method thereof, and disclose its purposes.
Background technique
Zinc is microelement necessary to animal, does not maintain only animal body growth and development institute required, and is also animal
Immune system normal development, the key for maintaining immune function.Zinc is the constituent or activator of a variety of enzymes in animal body, packet
Alkaline phosphatase, carbonic anhydrase, alcohol dehydrogenase, lactic dehydrogenase, glutamte dehydrogenase and carboxypeptidase etc., zinc and ribose core are included
The biosynthesis of sour DNA and protein has close ties, the constituent of zinc or insulin.When animal zinc-deficiency
When show as appetite stimulator, growth retardation, the incomplete angling of skin occurs therewith, zinc-deficiency has an effect on Bone Development for Animals and make to grow
Bone malformation, poultry propagation function reduction, hatching of breeding eggs rate reduce etc., and the proper splitting of animal immune cell when zinc-deficiency, point
Change is also suppressed, and the activity and quantity of immunocyte are greatly lowered, protein biosynthesis block, to damage the immune of body
Function.Reasonable zinc level can strengthening immune system, resistivity of the enhancing animal to disease.Geng Ailian etc. (1997) is with containing zinc
39.5, the Diet Hai Lanbai laying hen of 121.5,151.5,181.5,211.5 and 891.5mg/kg, through 10 weeks find, with
The content of the raising of feed zinc level, serum globulins significantly improves, and high zinc group serum IgG, IgM, IgA content dramatically increase.
Many researchers think that suitable zinc amount can increase animal appetite, enhance antioxidant ability of organism, promote pancreas islet
The synthesis and secretion of plain and insulin-like growth factor etc. promote breeding performonce fo animals to reinforce anabolism.Xu Zirong etc.
(2001) report Pharmacological Level of Zinc is seemingly a kind of group effect to the growth promoting function of pig, on the one hand by improving a poor appetite, improving and adopt
Appetite and feed digestibility and promote to grow；On the other hand, by removing interior free yl, immunity is improved, in genetic transcription
Level enhances the synthesis of certain zymoproteins, promotes the synthesis and secretion of insulin, reinforces anabolism and promotes growth.
Male animal zinc-deficiency can cause convoluted seminiferous tubule epithelial cell structure to be abnormal, cause gonad development and function by
Damage, Sperm specific enzyme are obstructed, sexual desire decline；Dam zinc-deficiency can lead to ovarian atrophy, and oestrous cycle disorder postpones heat or do not send out
Feelings, embryonic development is abnormal, and the death rate increases, and difficult labour, stillborn foetus and malformation fetus increase.Reasonable Zinc supplementation can improve animal
Reproductive performance.
High zinc (especially zinc oxide), it is most of to be excreted in environment with excrement, it can cause environment pollution.Canadian state
The maximum additive amount of zinc in daily ration is defined as 500mg/kg by feed association of family.Organic zinc especially zinc-amino acid chelate, such as
Zinc methionine acts on microelement necessary to growth of animal and amino acid, synthesizes the Chelating state chemical combination with cyclic structure
Object is a kind of micro element supplement agent close to natural form in animal body.Compared with inorganic zinc, have efficient, less toxic, low
Pollution, easy the features such as absorbing.Simultaneously as different tissues and enzyme system need ratio and quantity to certain amino acid in animal body
Difference, therefore by the zinc of chelating specific amino acids or peptides, it can be increased corresponding Zn-ef ficiency and transport each specific group
It knits and the chance (Fang Luoyun, 2001) in enzyme system.Studies have reported that zinc methionine is improving animal immunizing power, improve animal
Production performance, the significant effect for improving product quality etc. are higher than inorganic zinc (Wang Gang, 2006).But zinc-amino acid chelate is raw
Production. art is relative complex, higher cost, and cost and inorganic zinc are comparably 6-8: 1, limits popularization and application in production.So
And from the aspect of investment-return rate, 18 times higher than inorganic zinc of zinc-amino acid chelate or so (meter peak etc., 2001).
But with the progress of the development of feed industry and aquaculture, the feed addictives such as microelement, amino acid are had become
For the indispensable raw material of mixed feed.Various dose is added according to different animals nutritional need in people in mixed feed
The feed addictives such as microelement, amino acid carry out balanced nutrients composition, promote animal productiong, improvement product quality to reach, mention
High feed conversion rate reduces feeding cost, the purpose increased economic efficiency.
However, with amino-acid complex (chelating) microelement of the synthesis such as the higher lysine of price, methionine, glycine
Although biological value is higher, its use cost is also relatively high, especially under current feed market environment with keen competition, drop
The demand of low use cost is increasingly prominent.
Therefore, in order to reduce use cost, the present inventor makes full use of the locality that Guangxi cane planting is wide, sugar industry is flourishing
Affluent resources, by the complex reaction of sucrose and zinc salt, obtain sucrose zinc, greatly reduce enterprise using sucrose as primary raw material
Production cost, improve the competitiveness of enterprise.
Summary of the invention
It is a kind of with safe and efficient, high sexual valence the purpose of the present invention is In view of the above shortcomings of the prior art, providing
The advantage of ratio will play the sucrose zinc of positive guidance and impetus to the development of organic trace element industry even animal husbandry
Complex compound.
The present invention is implemented as follows:
The preparation method of sucrose zinc complex of the present invention includes the following steps:
Step 1: sucrose and water are uniformly mixed according to the ratio of weight fraction 25-32:40-50, according to sucrose and seven water
The weight fraction of zinc sulfate is that white vitriol is added in 25-32:85-100, and sodium hydrate aqueous solution adjusting pH 11-12 is added and obtains
To reaction solution；
Step 2: reaction solution obtained by step 1 is kept the temperature 1-2 hours under the conditions of 65-75 DEG C of temperature, being stirred continuously, it is cooling
It is separated by filtration, obtains filter residue and filtrate；
It is 1: 2 addition 75% by the weight ratio of filtrate and 75% ethanol water Step 3: taking filtrate obtained by step 2
Ethanol water room temperature precipitates 1.5-3 hours, and sediment is filtered by centrifugation, obtained waste water and sediment, and sediment is through true
Sky is dry, and detection obtains sucrose zinc product；
Step 4: taking filter residue in step 2 and detecting zinc ion concentration therein, according to the molar ratio of sucrose and zinc ion
Sucrose and zinc salt are added into filter residue for 1:4, takes step 3 to be centrifuged filtered waste water dissolution and sucrose is added and zinc salt is added
Filter residue, the pH 11-12 that adding sodium hydroxide aqueous solution adjusts solution obtain reaction solution；
Step 5: reaction solution in step 4 is taken to repeat Step 2: step 3 and step 4 are reacted, circular response is generated
Sucrose zinc.
The zinc salt is white vitriol.
The concentration of the sodium hydrate aqueous solution is 0.1-2mol/L.
The sucrose zinc complex is as feed addictive, and for the feeding of pig, chicken, duck, ox and sheep, additive amount is
200g/ tons of feeds.
There are a pair of of lone pair electrons, while transition metal ions (M=Cu on the glycosidic bond of sucrose (few disaccharides)2+、Zn2+、 Mn2 +、Fe2+、Ca2+) there is suitable unoccupied orbital, under suitable temperature environment " coordination effect ", after chemical reaction can be formed with sucrose
Complexing forms complex state metal, is absorbed and utilized conducive to animal body.It is as follows that it forms molecular structural formula:
Above-mentioned formula is sucrose microelement molecular structural formula, wherein M=Cu2+、Zn2+、Mn2+、Fe2+、Ca2+。
Because the reaction of sucrose trace-element complex is complicated, product is different from general amino-acid chelate, belong to more
In macromolecular structure, the molecular weight that does not determine.
The above-mentioned mechanism for preparing sucrose zinc is by sucrose and Zn2+After reacting forming complex, sucrose zinc complex is utilized
Insoluble in ethyl alcohol, Precipitation is then dry to can be obtained solid sucrose complexing zinc.
Inventor is first primary refiltering after the cooling of sucrose zinc solution before ethyl alcohol is added, and its object is to excessive
Microelement is remained in the form of filter residue, as one of sucrose circulation complex reaction object, by filtrate: the weight of 75% ethanol solution
It measures ratio=1: 2 and 75% ethanol solution progress room temperature precipitating is added, principle is: excessive microelement does not dissolve in ethyl alcohol, therefore
It to be filtered this out first before ethyl alcohol is added.Again ethyl alcohol polarity it is weaker, and sucrose zinc this be polyhydroxy salt, polarity compared with
Greatly, according to the principle of similar intermiscibility, sucrose zinc is slightly soluble in ethyl alcohol, the two is separated, so that it may obtain purer sucrose zinc
Product.And inventor is application No. is 201410463827.6, entitled " microelement sucrose complex compound feed addictive and its system
Preparation Method and application " patent be that various microelements are added and carry out complex reactions, what is obtained is using cane molasses as primary raw material
Microelement sucrose complex compound feed addictive is complicated premix.Just contain a large amount of impurity in cane molasses itself,
Microelement complexing is added again, excessive microelement and impurity are not removed, and obtained product is containing miscellaneous actually
The premix of matter and excessive microelement, compared with the present invention, the action function of the two is completely different.
The application method of sucrose zinc complex of the present invention is: after mixing with feed, for pig, chicken, duck, ox and sheep
Feeding, additive amount are 200g/ tons of feeds.
Compared with prior art, the positive effect of the present invention is:
1, sucrose zinc complex of the present invention obtains sucrose zinc solution by the complex reaction of sucrose and white vitriol,
It will be refiltered once after the cooling of sucrose zinc solution before ethyl alcohol is added, and filter residue and filtrate be obtained, by filtrate: 75% ethanol water
Weight ratio=1: 2 be added 75% ethanol waters carry out room temperature precipitatings after, will precipitating centrifugation filter, vacuum drying drying, sieve
Divide, detection, obtains purer sucrose zinc product；The zinc ion concentration of two filter residue of detecting step, according to sucrose and zinc ion
Molar ratio is 1:4, continuously adds sucrose and white vitriol, and step 3 is centrifuged filtered waste water and is returned in reaction kettle and is made
For the mother liquor of dissolving saccharose, circular response is carried out with identical reaction condition and continues to generate sucrose zinc.The present invention prepares sucrose zinc
Process, be the chemical process of a circular response, realize the recycling of the energy, meet the requirement of Green Chemistry, reduce
Production cost, improves production efficiency.
2, sucrose zinc complex of the present invention, due to sucrose addition and have fine palatability good, slight sugar sweet fragrance makes
It obtains livestock and poultry and likes feeding.
3, the present invention is using sucrose as primary raw material, obtained sucrose zinc, uses amino-acid complex (chelating) micro member with simple
Cost used in element is compared, and present invention reduces the use costs of 20-30%.
4, the complex compound of sucrose zinc of the present invention, dissolubility is good, it is easy absorb, stability it is good, can be obvious as feed addictive
The excrement excretion of feed source microelement is reduced, pollution of the aquaculture to environment is reduced, moreover it is possible to improve meat yellowish pink, enhance body
Anti-oxidation function, significantly improve the vigor of liver, GSH-Px in muscle, improve serum T-AOC and T-SOD, reduce UN, show
Writing improves the Nutrient Apparent Digestibilities such as feed CP, EE, calcium, phosphorus, increases the deposition of nitrogen, moreover it is possible to significantly improve serum levels of iron and liver iron contains
Amount.After sucrose manganese enters in animal stomach, absorbable organic zinc is generated with gastric acid slow reaction, can thus be promoted
Nascent quality, wean survival rate and the wean quality of piglet；The Intestinal Morphology for improving piglet, promotes the digestion of nutriment to inhale
It receives, adjusts animal growth.
5, the complex compound of sucrose zinc of the present invention, organic trace element amount ratio inorganic ions is few, and absorption rate is high
It 3-4 times out, not will cause waste, while problem of environmental pollution is improved, the safety of people be improved.
The above description is only an overview of the technical scheme of the present invention, in order to better understand the technical means of the present invention,
And it can be implemented in accordance with the contents of the specification, and in order to allow above and other objects, features and advantages of the invention can
It is clearer and more comprehensible, below in conjunction with preferred embodiment, detailed description are as follows.
Specific embodiment
The following detailed description of a specific embodiment of the invention, as part of this specification, by embodiment come
Illustrate that the principle of the present invention, other aspects of the present invention, feature and its advantage will become apparent by the detailed description.
Embodiment 1
The preparation method of sucrose zinc complex includes the following steps:
Step 1: add the sucrose of 25 parts by weight into reaction kettle, and after the water dissolving saccharose for adding 40 parts by weight, adding sodium hydroxide
It is water-soluble basified, adjust the pH 11 of solution；
Step 2: heating reaction kettle, keeps temperature in the kettle at 65 DEG C, adds 85 parts by weight white vitriols and be complexed
Reaction 1 hour, reaction process is stirred continuously, and generates sucrose zinc solution, and cold filtration separation obtains filter residue and filtrate；
Step 3: pressing filtrate: weight ratio=1 of 75% ethanol water: 2, which are added 75% ethanol water progress room temperature, sinks
It forms sediment, the sedimentation time is 1.5 hours, and sediment is filtered by centrifugation, and obtained Sewage treatment utilizes, and sediment is vacuum dried,
Detection obtains sucrose zinc product；
Step 4: the zinc ion concentration of two filter residue of detecting step, is 1:4 according to the molar ratio of sucrose and zinc ion, continues
The sucrose of 25 parts by weight and the white vitriol (63 parts by weight of zinc ion concentration measured here) of 22 parts by weight is added, by step
Filtered waste water is centrifuged in three back to the mother liquor in reaction kettle as dissolving saccharose, adding sodium hydroxide is water-soluble basified, tune
Save the pH 11 of solution；
Step 5: heating reaction kettle, keeps temperature in the kettle to carry out complex reaction between 65 DEG C, the condition of reaction process with
Step 2: step 3 is identical, circular response continues to generate sucrose zinc.
Embodiment 2
The preparation method of sucrose zinc complex includes the following steps:
Step 1: add the sucrose of 28 parts by weight into reaction kettle, and after the water dissolving saccharose for adding 45 parts by weight, adding sodium hydroxide
It is water-soluble basified, adjust the pH 11 of solution；
Step 2: heating reaction kettle, keeps temperature in the kettle at 70 DEG C, adds 95 parts by weight white vitriols and be complexed
Reaction 1.5 hours, reaction process is stirred continuously, and generates sucrose zinc solution, and cold filtration separation obtains filter residue and filtrate；
Step 3: pressing filtrate: weight ratio=1 of 75% ethanol water: 2, which are added 75% ethanol water progress room temperature, sinks
It forms sediment, the sedimentation time is 2 hours, and sediment is filtered by centrifugation, and obtained Sewage treatment utilizes, and sediment is vacuum dried, inspection
It surveys and obtains sucrose zinc product；
Step 4: the zinc ion concentration of filter residue, is 1:4 according to the molar ratio of sucrose and zinc ion, continuously adds 28 weight
Part sucrose and 25 parts by weight white vitriols (zinc ion concentration measured here is 70 parts by weight), step 2 is centrifuged and is filtered
Waste water afterwards returns to the mother liquor in reaction kettle as dissolving saccharose, and adding sodium hydroxide is water-soluble basified, adjusts the pH of solution
11；
Step 5: heating reaction kettle, keeps temperature in the kettle in 70 DEG C of progress complex reactions, the condition and step of reaction process
Two, step 3 is identical, and circular response continues to generate sucrose zinc.
Embodiment 3
The preparation method of sucrose zinc complex includes the following steps:
Step 1: add the sucrose of 32 parts by weight into reaction kettle, and after the water dissolving saccharose for adding 50 parts by weight, adding sodium hydroxide
It is water-soluble basified, adjust the pH 12 of solution；
Step 2: heating reaction kettle, keeps temperature in the kettle at 75 DEG C, adds 100 parts by weight white vitriols and carry out network
Reaction 2 hours is closed, reaction process is stirred continuously, and generates sucrose zinc solution, and cold filtration separation obtains filter residue and filtrate；
Step 3: pressing filtrate: weight ratio=1 of 75% ethanol water: 2, which are added 75% ethanol water progress room temperature, sinks
It forms sediment, the sedimentation time is 3 hours, and sediment is filtered by centrifugation, and obtained Sewage treatment utilizes, and sediment is vacuum dried, inspection
It surveys and obtains sucrose zinc product；
Step 4: in detecting step two filter residue zinc ion concentration, according to the molar ratio of sucrose and zinc ion be 1:4, after
It is continuous that 32 parts by weight of sucrose and 25 parts by weight white vitriols (zinc ion concentration measured here is 75 parts by weight) are added, it will walk
The filtered waste water of rapid 1) centrifugation returns to the mother liquor in reaction kettle as dissolving saccharose, and adding sodium hydroxide is water-soluble basified, adjusts
Save the pH 12 of solution；
Step 5: heating reaction kettle, keeps temperature in the kettle in 75 DEG C of progress complex reactions, the condition and step of reaction process
Two, step 3 is identical, and circular response continues to generate sucrose zinc.
Application implementation test
1, experimental design: basal diet is identical, and the additive amount of zinc is 100mg/kg, and test is divided into two processing, right
Zinc source is provided according to a group inorganic zinc (100% zinc sulfate), test group sucrose zinc provides zinc source, and each processing group sets 3 repetitions
2, the source of test material: inorganic zinc (feed level zinc sulfate) market purchasing, organic zinc (sucrose zinc) is by Nan Ningze
Weir feed Co., Ltd develops
3, experimental animal and Nutrition Management: test selects 28 ages in days to wean tri-crossbreeding 18, according to weight, gender
The consistency principle is divided into 2 groups, receive a kind of processing method at random；Colony house uses slatted floor child care equipment, and house temperature control system exists
25 DEG C of 22-, relative humidity is controlled in 65%-75%.Experiment the last week cleans pig house and various feeding utensils, is washed away
And disinfection keeps colony house ventilation, cleaning, drying with facilities such as caustic soda sprinkling ground, fence, troughs during experiment；It is artificial to add
Material, is freely eaten and drinking-water, conventinal breeding management, experimental period 28d, early period are (1-14d) and later period (15-28d) two week
Phase.
4, testing index and method
On-test weighing, grouping, test 14d and 28d, stop weighing after expecting 12h, calculate the average day for testing each period pig
Weight gain, records daily feeding coal and feed intake.
6, result and analysis
In the weanling pig daily ration of routine dose zinc supplementation (100mg/kg), zinc sulfate and sucrose zinc are to weanling pig growth
The influence such as table 1 of energy.
1 zinc sulfate of table and influence of the sucrose zinc to Growth Performance of Weaning Piglets
| Project | Sucrose zinc group | Zinc sulfate group |
| Starting weight (kg) | 6.93±0.14 | 6.92±0.12 |
| End weight (kg) | 16.81±0.82 | 16.31±0.086 |
| Daily gain early period (g/d) | 276±42.3 | 218±20.7 |
| Later period daily gain (g/d) | 418±14.8 | 450±53.5 |
| Full period daily gain (g/d) | 347±35.6 | 336±25.5 |
| Feed intake early period (g/d) | 349±19.8 | 281±26.4 |
| Later period feed intake (g/d) | 703±29.4 | 676±53.9 |
| Full period feed intake (g/d) | 528±49.4 | 479±29.4 |
| Early period feed-weight ratio | 1.27±0.078 | 1.29±0.065 |
| Later period feed-weight ratio | 1.70±0.086 | 1.48±0.105 |
| Full period feed-weight ratio | 1.54±0.044 | 1.42±0.046 |
As seen from the above table: using one group of the sucrose zinc feed intake in early period than using one group of zinc sulfate to increase 26.1%
More than, daily gain improves 22.6% or more, and feed-weight ratio improves 4.2%.Result of study shows organic zinc source (sucrose zinc) to disconnected
The effect that milk piglet growth performance influences is more obvious than the effect of zinc sulfate.
Compared with prior art, the positive effect of the present invention is:
1, sucrose zinc complex of the present invention obtains sucrose zinc solution by the complex reaction of sucrose and white vitriol,
It will be refiltered once after the cooling of sucrose zinc solution before ethyl alcohol is added, and filter residue and filtrate be obtained, by filtrate: 75% ethanol water
Weight ratio=1: 2 be added 75% ethanol waters carry out room temperature precipitatings after, will precipitating centrifugation filter, vacuum drying drying, sieve
Divide, detection, obtains purer sucrose zinc product；The zinc ion concentration of two filter residue of detecting step, according to sucrose and zinc ion
Molar ratio is 1: 4, continuously adds sucrose and white vitriol, and step 3 is centrifuged filtered waste water and is returned in reaction kettle and is made
For the mother liquor of dissolving saccharose, circular response is carried out with identical reaction condition and continues to generate sucrose zinc.The present invention prepares sucrose zinc
Process, be the chemical process of a circular response, realize the recycling of the energy, meet the requirement of Green Chemistry, reduce
Production cost, improves production efficiency.
2, sucrose zinc complex of the present invention, due to sucrose addition and have fine palatability good, slight sugar sweet fragrance makes
It obtains livestock and poultry and likes feeding.
3, the present invention is using sucrose as primary raw material, obtained sucrose zinc, uses amino-acid complex (chelating) micro member with simple
Cost used in element is compared, and present invention reduces the use costs of 20-30%.
4, the complex compound of sucrose zinc of the present invention, dissolubility is good, it is easy absorb, stability it is good, can be obvious as feed addictive
The excrement excretion of feed source microelement is reduced, pollution of the aquaculture to environment is reduced, moreover it is possible to improve meat yellowish pink, enhance body
Anti-oxidation function, significantly improve the vigor of liver, GSH-Px in muscle, improve serum T-AOC and T-SOD, reduce UN, show
Writing improves the Nutrient Apparent Digestibilities such as feed CP, EE, calcium, phosphorus, increases the deposition of nitrogen, moreover it is possible to significantly improve serum levels of iron and liver iron contains
Amount.After sucrose manganese enters in animal stomach, absorbable organic zinc is generated with gastric acid slow reaction, can thus be promoted
Nascent quality, wean survival rate and the wean quality of piglet；The Intestinal Morphology for improving piglet, promotes the digestion of nutriment to inhale
It receives, adjusts animal growth.
5, the complex compound of sucrose zinc of the present invention, organic trace element amount ratio inorganic ions is few, and absorption rate is high
It 3-4 times out, not will cause waste, while problem of environmental pollution is improved, the safety of people be improved.
The above is a preferred embodiment of the present invention, cannot limit the right model of the present invention with this certainly
It encloses, it is noted that for those skilled in the art, without departing from the principle of the present invention, may be used also
To make several improvement and variation, these, which improve and change, is also considered as protection scope of the present invention.
Claims (2)
1. a kind of preparation method of sucrose zinc complex, which comprises the steps of:
Step 1: sucrose and water are uniformly mixed according to the ratio of weight fraction 25-32:40-50, according to sucrose and seven water sulfuric acid
The weight fraction of zinc is that white vitriol is added in 25-32:85-100, and sodium hydrate aqueous solution adjusting pH 11-12 is added and obtains instead
Answer liquid；
Step 2: reaction solution obtained by step 1 is kept the temperature 1-2 hours under the conditions of 65-75 DEG C of temperature, being stirred continuously, cold filtration
Separation, obtains filter residue and filtrate；
It is 1: 2 75% ethyl alcohol of addition by the weight ratio of filtrate and 75% ethanol water Step 3: taking filtrate obtained by step 2
Aqueous solution room temperature precipitates 1.5-3 hours, and sediment is filtered by centrifugation, obtained waste water and sediment, and sediment is dry through vacuum
Dry, detection obtains sucrose zinc product；
It is 1:4 according to the molar ratio of sucrose and zinc ion Step 4: taking filter residue in step 2 and detecting zinc ion concentration therein
Sucrose and zinc salt are added into filter residue, takes step 3 to be centrifuged filtered waste water dissolution and sucrose is added and the filter residue of zinc salt is added,
The pH 11-12 that adding sodium hydroxide aqueous solution adjusts solution obtains reaction solution；
Step 5: reaction solution in step 4 is taken to repeat Step 2: step 3 and step 4 are reacted, circular response generates sucrose
Zinc；
The zinc salt is white vitriol；
The concentration of the sodium hydrate aqueous solution is 0.1-2mol/L.
2. the preparation method of sucrose zinc complex as described in claim 1, it is characterised in that: the sucrose zinc complex conduct
Feed addictive, for the feeding of pig, chicken, duck, ox and sheep, additive amount is 200g/ tons of feeds.
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| US20090299052A1 (en) * | 2004-12-06 | 2009-12-03 | Emcure Pharmaceuticals Limited | cost-effective process for preparation of manufacture of iron sucrose |
| CN101671373A (en) * | 2009-10-10 | 2010-03-17 | 天津中敖生物科技有限公司 | Preparation method for iron sucrose bulk drug and injection thereof |
| CN103040730A (en) * | 2011-10-13 | 2013-04-17 | 天津中敖生物科技有限公司 | Iron sucrose injection and preparation method thereof |
| CN104206735A (en) * | 2014-09-13 | 2014-12-17 | 南宁市泽威尔饲料有限责任公司 | Microelement sucrose complex feed additive as well as preparation method and application thereof |
| CN105145253A (en) * | 2015-09-10 | 2015-12-16 | 南宁市马山县福源生态农业发展有限公司 | Method for planting organic passion fruit trees |
| CN105394351A (en) * | 2015-10-27 | 2016-03-16 | 南宁市泽威尔饲料有限责任公司 | Oligosaccharide chelated composite trace element mineral matter supplement and preparation method thereof |
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