CN104095917A - Chinese patent medicine for treating child hyperpyretic convulsion and preparation method thereof - Google Patents
Chinese patent medicine for treating child hyperpyretic convulsion and preparation method thereof Download PDFInfo
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- CN104095917A CN104095917A CN201410288027.5A CN201410288027A CN104095917A CN 104095917 A CN104095917 A CN 104095917A CN 201410288027 A CN201410288027 A CN 201410288027A CN 104095917 A CN104095917 A CN 104095917A
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Abstract
The invention provides Chinese patent medicine, ginseng bezoar powder, used for treating child hyperpyretic convulsion. The Chinese patent medicine comprises the following traditional Chinese medicinal materials by weight: 900-1100 parts of in vitro cultivated bezoar, 850-1150 parts of ginseng and 400-600 parts of peppermint water, and the peppermint water is packaged independently; the in vitro cultivated bezoar, which is first type new national traditional Chinese medicine, is chosen as the main medicine, so that the Chinese patent medicine is enabled to have better heat clearing and anticonvulsant effects; a new superfine smashing technology is adopted, and the medicine is used with powder, high in medicinal material availability, small in taking dosage every time and higher in safety, and suitable for patients to take for a long time. According to the invention, the Chinese patent medicine has the functions of clearing away heart-fire and calming liver, and relieving worry, dizziness and fright, has a stable and prominent curative effect on treating the child hyperpyretic convulsion, and can treat both manifestation and root cause of diseases, and repeated attacks can be effectively prevented.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly relate to a kind of compound Chinese medicinal preparation for the treatment of children with high fever induced convulsions and preparation method thereof.
Background technology
Children with high fever induced convulsions (Febrile convulsion, FC) refer to the high heat due to the non-central nervous system infection of children's and the convulsions that causes, it is the common emergency case of department of pediatrics, mainly betide 6 months～5 years old children's, the child morbidity rate of majority state report is 2%-5%, and China's investigation is 3.9%.Approximately 50% pure febrile convulsion infant afterwards adstante febre shows effect again or repeatedly, and the number of times of reaccessing is more, and the probability that brain injury occurs is higher, and the ratio that changes epilepsy into also increases.
Clinical manifestation is body temperature when more than 38 ℃, and on loss of consciousness, two, turning over, staring or looking side ways appears in sudden onset, there is general or local convulsion simultaneously, the time of origin several seconds, severe patient can show effect repeatedly, is even persistent state threat to life to several minutes.It is a kind of special epilepsy syndrome in children's's period, the about 3%-4% of sickness rate, and there is higher relapse rate, domestic data shows that relapse rate is 30%-40%, approximately have 5% to develop into epilepsy, FC can be divided into two kinds of pure (simple febrile convulsion, SFC) and complexity (complex febrile convulsion, CFC).
Doctor trained in Western medicine is mainly to give oral anticonvulsant drug prevention hyperpyrexia convulsion recurrence at present, but short term effect and late result are imprecise, need long-term prescription, the generally at least 2 years course for the treatment of, and this type of medicine has inhibitory action widely to central nervous system, if long-term taking will affect the neural growth promoter of children's, affect children's's cognitive competence, so method loses more than gain.And in hyperpyrexia convulsion non-acute stage without effective prevention method.Children with high fever induced convulsions belongs to the category of the traditional Chinese medical science " acute infantile convulsion ".At present, utilize treatment by Chinese herbs hyperpyrexia convulsion to report to some extent, most literature report take heat clearing away, eliminating phlegm, relieve dizziness, high fever, infantile convulsions, epilepsy, etc., relieving convulsion be fundamentum, in general, stage of attack bring down a fever spasmolytic effect still can, but to nearly unavailable fruit in prevention of recurrence.
The pure technology of Chinese medicine ultra-fine powder has been brought a revolution to innovation of Chinese medicinal dosage form and the modernization of Chinese medicine; owing to having improved cell wall breaking rate, specific surface area, effective ingredient dissolution, bioavailability; pharmacological action be can strengthen, reduce dosage, medical material and protection herb resource saved; also can improve abnormal smells from the patient, mouthfeel simultaneously, improve drug quality.
Summary of the invention
Object of the present invention, be exactly object of the present invention be exactly for above-mentioned the deficiencies in the prior art, provide a kind of and be used as medicine and simple process with In vitro cultured Calculus Bovis, the compound Chinese medicinal preparation Radix Ginseng Calculus Bovis that curative effect is treated children with high fever induced convulsions is preferably loose.
Technical solution of the present invention is:
A kind of Chinese patent medicine-Radix Ginseng Calculus Bovis for the treatment of children with high fever induced convulsions falls apart, and it is characterized in that: the Chinese crude drug that comprises following weight component: In vitro cultured Calculus Bovis 900-1100 part, and Radix Ginseng 850-1150 part, aqua methnae 400-600 part, wherein aqua methnae separately wraps.
A kind of preferred technical solution is: a kind of Chinese patent medicine-Radix Ginseng Calculus Bovis for the treatment of children with high fever induced convulsions falls apart; it is characterized in that: the Chinese crude drug that comprises following weight component: 900 parts of In vitro cultured Calculus Boviss; 850 parts of Radix Ginsengs, 400 parts of aqua methnae, wherein aqua methnae separately wraps.
Prepare the loose method of Chinese patent medicine-Radix Ginseng Calculus Bovis for the treatment of children with high fever induced convulsions, it is characterized in that: step is as follows:
The first step: get Radix Ginseng Chinese crude drug, obtain dry ginseng's decoction pieces after only making, dry and cooling;
Second step: measure dry ginseng's decoction pieces and In vitro cultured Calculus Bovis by prescription, pulverize through disintegrating machine, and mix rear mistake 50～100 mesh sieves, obtain Radix Ginseng Calculus Bovis coarse powder;
The 3rd step: get Radix Ginseng Calculus Bovis coarse powder, ultra micro shatters rear mistake 200～500 mesh sieves, obtains Radix Ginseng Calculus Bovis superfine powder;
The 4th step: get Radix Ginseng Calculus Bovis superfine powder and add appropriate alcoholic solution soft material processed, then cross 14～40 mesh sieves and obtain wet granular, must do granule after 40～90 ℃ of oven dry;
The 5th step: by 2 mistake 18～40 mesh sieves of dry granule, obtain finished granule, by finished granule subpackage, separately get Herba Menthae Aromatic water and separately wrap according to quantity.
Press recipe quantity, with warm boiled water, granule is taken with Herba Menthae Aromatic water simultaneously.
The present invention be advantageous in that: febrile convulsion infants conscience is had a surplus especially outstanding, surpassed normal physiological range, and this causes the basic reason that children with high fever induced convulsions occurs just.From stabilizing the excessive pathogenesis of having a surplus of conscience, set about, from organic conception, take into account and improve immunity and reduce convulsions susceptibility, develop a kind of for prevention and treatment children with high fever induced convulsions innovation compound Chinese medicinal preparation, this Chinese medicine has the suppressing the hyperactive liver of clearing away heart-fire, the relieve dizziness, high fever, infantile convulsions, epilepsy, etc. effect of spasmolytic of emergency.To children with high fever induced convulsions treating both the principal and secondary aspects of a disease, effectively solve easily the problem of outbreak repeatedly, when curing the disease, improve infant body constitution, improve its resistance against diseases.This is according to traditional Chinese medicine theory reasonable formula, the production of believing and put on market after, development prospect is huge, economic benefits.
Through demonstrations such as pharmacodynamics for many years, toxicology tests, steady quality of the present invention, safe and reliable:
1. pharmacodynamic study:
Product of the present invention has significant heat clearing away, anticonvulsant effect.Radix Ginseng Calculus Bovis is loose to be caused rat fever, typhoid fever paratyphoid fever triple vaccine to yeast and causes fever in rabbits and 2,4-DNP and cause fever in rabbits and all have obvious inhibitory action; Caffeine and sodium benzoate is caused to mice convulsion and pentetrazole causes mice convulsion, all have obvious antagonism.The present invention to hot bath induction SD rat convulsions animal model test result childhood show, can faint from fear incubation period by significant prolongation rat, can significantly shorten duration of status convulsion, can significantly reduce convulsive attack degree.
2. stability experiment:
The present invention carries out 0-24 month observation to three batch samples of trial production, investigates result and shows that the indexs such as its character, discriminating, content, the outward appearance uniformity, moisture, microbial limit have no significant change, and show steady quality of the present invention.
3. toxicologic study:
Product of the present invention is pressed maximum dosage-feeding to the administration of NIH mouse stomach with Cmax, and a TDD is 9.6g crude drug/kg, and the animal appearance activity of administration rear section reduces, and look asthenia, has no other obvious abnormal response in addition.After 3 hours, it is normal that animal recovers substantially.Continuous Observation has no animal dead on the 14th, and Normal-weight increases.Last is put to death mice after weighing and is cutd open inspection, perusal, main organs no abnormality seen.Can think: Radix Ginseng Calculus Bovis is loose to be given maximum dose 9.6g crude drug/kg(to NIH mouse stomach and be approximately equivalent to 87.5 times of clinical consumption per day), have no overt toxicity.
Composition principle of the present invention: in side, Calculus Bovis has heat-clearing and toxic substances removing, endogenous wind stopping relieving convulsion, the effect of waking up the patient from unconsciousness by dissipating phlegm, cures mainly epidemic febrile disease and infantile convulsion, high fever coma, spasm tic.As < < herbal classic > > cloud: " main infantile convulsion cold and heat; the mad convulsion of intenseness of heat ", and < < Mingyi Bielu > > cloud: " treating children's's all kinds of diseases and ailments; all epilepsy heat; mouth is not opened; adult is mad insane, again degeneration ".Modern pharmacology confirms, and Calculus Bovis has antipyretic and cooling effect, can reduce rat temperature due to yeast and 2,4-dinitrophenol, can reduce normal rat body temperature.Taurine is one of effective ingredient of Calculus Bovis refrigeration function; Calculus Bovis also has anticonvulsant effect, and Calculus Bovis can resist the mice convulsion that caffeine, Picrotoxin, pentetrazole etc. cause, extends the incubation period of fainting from fear.Taurine is the effective ingredient of Calculus Bovis central nerve inhibition effect, and cortex, brain stem, spinal cord are all had to certain inhibitory action, thinks that at present taurine may be a kind of maincenter inhibitory aminoacid.In side, Radix Ginseng has strongly invigorating primordial QI, and multiple arteries and veins is admittedly de-, and invigorating the spleen to benefit the lung, promotes the production of body fluid, the effect of calming the nerves.For weak body and prostration, interior-heat is quenched one's thirst, and prolonged illness is empty wins, palpitation with fear insomnia.As < < herbal classic > >, record Radix Ginseng " spasmolytic is throbbed with fear, and removes pathogen for tonifying five ZANG-organs, peace spirit, improving eyesight, happy Fructus Alpiniae Oxyphyllae ".Modern pharmacology confirms, Radix Ginseng is to central nervous excitation and inhibition regulating action, nootropic effect and anticonvulsant action on the main manifestations that affects of central functions, Radix Ginseng has enhancing human body immunity function in addition, engulf the clean up ability of the reticuloendothelial system that ginsenoside can strengthen many animals to colloid carbon granules, staphylococcus aureus, chicken red blood cell, promotes the complement of guinea pig serum to generate.Ginsenoside and ginseng polysaccharide are the effective ingredient that Radix Ginseng improves immunologic function.Aqua methnae is current clinical conventional taste masking, carminative, is mainly used in taste masking and gastrointestinal aerofluxus.All medicine compatibilities are proper, have the suppressing the hyperactive liver of clearing away heart-fire, the emergency spasmolytic effect that relieves dizziness, high fever, infantile convulsions, epilepsy, etc.The party forms rationally, and each component is at the row of " eighteen incompatible medicaments ", " nineteen medicaments of mutual restraint ", and without incompatibility.
In addition the present invention's prescription has good ancient literature basis; formula for a product derives from the total micro-side > > volume three of < children's < health: " fever of the body Fang Zhi; Radix Ginseng Calculus Bovis is loose, treatment children's fever (of children) accompanied by fear is as fire.Also control Wen Zhuan." " with Radix Ginseng Calculus Bovis, be divided into end; the aqua methnae of take is adjusted lower to good " Wen Zhuan is on the books in < < chao's treatise on the causes and symptoms of diseases > > < < Taiping Royal Prescriptions > >, is the exclusive name of disease of department of pediatrics in ancient times.Above-mentioned two books claim: " children's Wen Zhuanzhe, uncomfortable by internal organs, inside there is latent heat, or hold Su Han under the arm, all fight in gastric qi.Foot sun is bright is the warp of stomach, the muscle of main body.Its discomfort in the stomach, the capable heap soil or fertilizer over and around the roots of gas is puckery, therefore accumulate long-pending body heat, Wen Zhuan by name ".
Product of the present invention is used as medicine with national Chinese medicine one kind new medicine-In vitro cultured Calculus Bovis; make this product there is better heat clearing away, anticonvulsant effect; adopt ultra micro to shatter technology new technique; with powder, be used as medicine; effectively improved medical material availability high; reduced dosage, safety is higher, suitable patient's long-term taking.Chinese medicine preparation of the present invention has the suppressing the hyperactive liver of clearing away heart-fire, the relieve dizziness, high fever, infantile convulsions, epilepsy, etc. medicinal efficacy of spasmolytic of emergency, and treatment children with high fever induced convulsions clinical efficacy is stable outstanding, can treating both the principal and secondary aspects of a disease, and can effectively prevent repeatedly to show effect.
The specific embodiment
Embodiment 1
Get Radix Ginseng and spread out and select the impurity being wherein mingled with, clean and remove impurity, after draining away the water, the Radix Ginseng slice that must wet, dries under 50～90 ℃ of conditions, must dry ginseng's decoction pieces after cooling.By recipe quantity, take respectively dry ginseng's decoction pieces 900g, In vitro cultured Calculus Bovis 850g, after pulverizer pulverizing mixes, 50～100 mesh sieves obtain coarse powder excessively, and coarse powder shatters through ultra micro again, excessively after 200～500 mesh sieves, obtains superfine powder.In Radix Ginseng Calculus Bovis superfine powder, add appropriate alcoholic solution soft material processed; 14～40 mesh sieves are granulated; wet granular is dry under 40～90 ℃ of conditions; must do granule; dry granule is chosen 18～40 order granule packagings and is become finished product after 2 screenings; aqua methnae 400ml separately wraps, and finally will divide the dry finished granule of Radix Ginseng Calculus Bovis of wrapping and divide the aqua methnae of wrapping by recipe quantity mounted box.
Embodiment 2
Get Radix Ginseng and spread out and select the impurity being wherein mingled with, clean and remove impurity, after draining away the water, the Radix Ginseng slice that must wet, dries under 50～90 ℃ of conditions, must dry ginseng's decoction pieces after cooling.By recipe quantity, take respectively dry ginseng's decoction pieces 1100g, In vitro cultured Calculus Bovis 1150g, after pulverizer pulverizing mixes, 50～100 mesh sieves of looking over so as to check obtain coarse powder, and coarse powder shatters through ultra micro again, excessively after 200～500 mesh sieves, obtains superfine powder.In Radix Ginseng Calculus Bovis superfine powder, add appropriate alcoholic solution soft material processed; 14～40 mesh sieves are granulated; wet granular is dry under 40～90 ℃ of conditions; must do granule; dry granule is chosen 18～40 order granule packagings and is become finished product after 2 screenings; aqua methnae 600ml separately wraps, and finally will divide the dry finished granule of Radix Ginseng Calculus Bovis of wrapping and divide the aqua methnae of wrapping by recipe quantity mounted box.
Claims (3)
1. Chinese patent medicine-Radix Ginseng Calculus Bovis for the treatment of children with high fever induced convulsions is loose, it is characterized in that: the Chinese crude drug that comprises following weight component: In vitro cultured Calculus Bovis 900-1100 part, and Radix Ginseng 850-1150 part, aqua methnae 400-600 part, wherein aqua methnae separately wraps.
2. a kind of Chinese patent medicine-Radix Ginseng Calculus Bovis for the treatment of children with high fever induced convulsions as claimed in claim 1 falls apart, and it is characterized in that: the Chinese crude drug that comprises following weight component: 900 parts of In vitro cultured Calculus Boviss, and 850 parts of Radix Ginsengs, 400 parts of aqua methnae, wherein aqua methnae separately wraps.
3. the loose method of Chinese patent medicine-Radix Ginseng Calculus Bovis of preparing treatment children with high fever induced convulsions as claimed in claim 1, is characterized in that: step is as follows:
The first step: get Radix Ginseng Chinese crude drug, obtain dry ginseng's decoction pieces after only making, dry and cooling;
Second step: measure dry ginseng's decoction pieces and In vitro cultured Calculus Bovis by prescription, pulverize through disintegrating machine, and mix rear mistake 50～100 mesh sieves, obtain Radix Ginseng Calculus Bovis coarse powder;
The 3rd step: get Radix Ginseng Calculus Bovis coarse powder, ultra micro shatters rear mistake 200～500 mesh sieves, obtains Radix Ginseng Calculus Bovis superfine powder;
The 4th step: get Radix Ginseng Calculus Bovis superfine powder and add appropriate alcoholic solution soft material processed, then cross 14～40 mesh sieves and obtain wet granular, must do granule after 40～90 ℃ of oven dry;
The 5th step: by 2 mistake 18～40 mesh sieves of dry granule, obtain finished granule, by finished granule subpackage, separately get Herba Menthae Aromatic water and separately wrap according to quantity, finally will divide the dry finished granule of Radix Ginseng Calculus Bovis of wrapping and divide the aqua methnae of wrapping by recipe quantity mounted box.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113730502A (en) * | 2021-09-29 | 2021-12-03 | 陕西盘龙药业集团股份有限公司 | Pharmaceutical application of bezoar anticonvulsant cultured in vitro, pharmaceutical composition based on bezoar anticonvulsant cultured in vitro and preparation method of pharmaceutical composition |
| CN114504604A (en) * | 2022-04-08 | 2022-05-17 | 中国中医科学院中药研究所 | Traditional Chinese medicine composition for treating infectious fever and preparation method thereof |
-
2014
- 2014-06-25 CN CN201410288027.5A patent/CN104095917A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 佚名: "《小儿卫生总微论方》", 31 August 1958, 上海卫生出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113730502A (en) * | 2021-09-29 | 2021-12-03 | 陕西盘龙药业集团股份有限公司 | Pharmaceutical application of bezoar anticonvulsant cultured in vitro, pharmaceutical composition based on bezoar anticonvulsant cultured in vitro and preparation method of pharmaceutical composition |
| CN114504604A (en) * | 2022-04-08 | 2022-05-17 | 中国中医科学院中药研究所 | Traditional Chinese medicine composition for treating infectious fever and preparation method thereof |
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Application publication date: 20141015 |