CN107228824A - A kind of sticky detection method of medical bio bressing - Google Patents
A kind of sticky detection method of medical bio bressing Download PDFInfo
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- CN107228824A CN107228824A CN201710366770.1A CN201710366770A CN107228824A CN 107228824 A CN107228824 A CN 107228824A CN 201710366770 A CN201710366770 A CN 201710366770A CN 107228824 A CN107228824 A CN 107228824A
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- 238000001514 detection method Methods 0.000 title claims abstract description 40
- 238000012360 testing method Methods 0.000 claims abstract description 50
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000002504 physiological saline solution Substances 0.000 claims abstract description 8
- 102000009123 Fibrin Human genes 0.000 claims description 20
- 108010073385 Fibrin Proteins 0.000 claims description 20
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 20
- 229950003499 fibrin Drugs 0.000 claims description 20
- 241001465754 Metazoa Species 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 14
- 229920001661 Chitosan Polymers 0.000 claims description 12
- 102000008186 Collagen Human genes 0.000 claims description 11
- 108010035532 Collagen Proteins 0.000 claims description 11
- 238000012545 processing Methods 0.000 claims description 11
- 239000004744 fabric Substances 0.000 claims description 10
- 239000000853 adhesive Substances 0.000 claims description 9
- 230000001070 adhesive effect Effects 0.000 claims description 9
- 239000010985 leather Substances 0.000 claims description 5
- 210000003491 skin Anatomy 0.000 claims description 5
- 230000008569 process Effects 0.000 claims description 4
- 210000002615 epidermis Anatomy 0.000 claims description 3
- 239000004627 regenerated cellulose Substances 0.000 claims description 3
- 230000008901 benefit Effects 0.000 abstract description 2
- 208000027418 Wounds and injury Diseases 0.000 description 18
- 239000002390 adhesive tape Substances 0.000 description 12
- 238000004519 manufacturing process Methods 0.000 description 11
- 241000143060 Americamysis bahia Species 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 5
- 241001460053 Laides Species 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 229910001220 stainless steel Inorganic materials 0.000 description 5
- 239000010935 stainless steel Substances 0.000 description 5
- 229920000742 Cotton Polymers 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 239000000835 fiber Substances 0.000 description 4
- 239000004745 nonwoven fabric Substances 0.000 description 4
- 238000005096 rolling process Methods 0.000 description 4
- 239000003643 water by type Substances 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 229910000831 Steel Inorganic materials 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 238000012827 research and development Methods 0.000 description 2
- 238000004088 simulation Methods 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 108010034963 tachocomb Proteins 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 1
- 206010054949 Metaplasia Diseases 0.000 description 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
- 208000031737 Tissue Adhesions Diseases 0.000 description 1
- 206010051373 Wound haemorrhage Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000015689 metaplastic ossification Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- 229910052760 oxygen Inorganic materials 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N19/00—Investigating materials by mechanical methods
- G01N19/04—Measuring adhesive force between materials, e.g. of sealing tape, of coating
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention relates to a kind of sticky detection method of medical bio bressing, the sticky detection method of medical bio bressing of the present invention comprises the following steps：Medical bio bressing is fixed on breadboard, then water or physiological saline are uniformly sprayed on medical bio bressing, take again and stick medium and medical bio bressing bonding, then determine medical bio bressing with universal testing machine or peeling strength test machine and stick the peel strength after medium bonding.Sticky detection method of the present invention embodies the viscosity of medical bio bressing with peel strength, has the advantages that to quantify that detection, stability is high, repeatability is high.
Description
Technical field
The invention belongs to the analysis detection field of medical material, and in particular to a kind of sticky detection side of medical bio bressing
Method.
Background technology
Medical bio bressing common at present includes chitosan sponge, oxidized regenerated cellulose dressing, gelfoam, collagen
Protein sponge, fibrin patch, adhesive fibrin etc., medical bio bressing is contacted with the surface of a wound, is sticked on the surface of a wound and is played
Protection and anastalsis.
Absorbability, permeability, bioaffinity, bonding strength, mechanical strength of medical bio bressing etc. are all to evaluate it
The index of performance.Wherein, bonding strength is an important indicator of medical bio bressing, unfavorable if the viscosity of dressing is too weak
In the extraneous foreign matter of isolation or microorganism, if the viscosity of dressing is too strong, the surface of a wound of easily being adhered when changing causes machine again
Tool is damaged, the viscosity of the dressing that the surface of a wound of different situations is applicable also difference.Therefore, in the researching and developing of medical bio bressing, raw
During production and use, it is required for detecting its viscosity, the firmness adhered to the surface of a wound during determining that dressing is used.So
And in a practical situation, because when dressing is contacted with the surface of a wound, its viscosity can be with the uptake to blood or diffusate and absorption
The change of time and change, so can only by rule of thumb be gone to evaluate the viscosity of dressing by medical personnel, and can only provide qualitatively
As a result, it is impossible to which the index of quantitative goes to assess the viscosity of dressing, it is difficult to instruct the R＆D work and industry of medical bio bressing
Metaplasia is produced.
The conventional method being measured to the viscosity of material has rolling ball method etc., the applicable object model of this class detection method
Enclose wide, the specific aim to medical bio bressing is not strong.For example, rolling ball method applies to pressure-sensitive tape and similar to pressure-sensitive adhesive
The test of the tack of alternate product, cardinal principle is the adhesive faces in the adhesive tape adhesiveness face, according to the rules length that roll across steel ball
The maximum ball size that can be clung assesses its sticky size, or the steel ball of a prescribed level is rolled across into adhesive tape adhesiveness face,
The size that its is sticky is assessed with the distance of its rolling.But, the testing procedure of rolling ball method and actually making for medical bio bressing
It is very big with difference in operation, it is difficult to embody viscosity of the dressing in practical application；Secondly, the method for testing step is complicated, stable
Property, poor repeatability；Moreover, this method is unable to the index of quantitative as evaluation criteria, can only entry evaluation dressing viscosity.
The adhesion testing of Tachocomb surface of a wound bleeding-stopping dressing is also a kind of tack determination method, and it utilizes the surface of a wound in animal body
Viscosity to dressing carries out qualitative evaluation.The detection method although simulate dressing be used for stop blooding with the practical application of tissue adhesion
Scene, but stability and poor repeatability, its measurement result is easily by animal individual difference, the skilled operation degree of tester
Or the influence of surgical experience；Secondly, the detection method also fails to the index of quantitative as evaluation criteria；Furthermore, this method
It is mainly used in investigating the viscosity of Tachocomb this dressing in surgical operation with organ wound, is not suitable for determining other medical lifes
The viscosity of thing dressing, is not suitable for determining the viscosity of dressing and surface wound yet；Moreover, this method needs to use animal body, move
The processing cost that the supply of object is difficult to meet animal body after substantial amounts of determination test, experiment is high.
Therefore, because special role and the complexity of use environment of medical bio bressing, existing sticky detection method
It can not quantify, detect the viscosity of medical bio bressing exactly, and there is stability, poor repeatability, to the behaviour of tester
The shortcomings of being required high.At present, in medical material industry also it is not a kind of can quantitatively, detect medical bio bressing exactly
Sticky detection method.
The content of the invention
Based on this, it is an object of the present invention to provide a kind of sticky detection method of medical bio bressing, it has can be fixed
Amount detection, the advantage that stability is high, repeatability is high.
The technical solution adopted by the present invention is as follows：
A kind of sticky detection method of medical bio bressing, comprises the following steps：
Medical bio bressing is fixed on breadboard, water or physiological saline are uniformly then sprayed at medical bio bressing
On, then take and stick medium and medical bio bressing and bond, then determine medical life with universal testing machine or peeling strength test machine
Thing dressing is with sticking the peel strength after medium bonding.
Relative to existing sticky detection method, the present invention is determined using universal testing machine or peel strength machine and peeled off by force
Degree, using the peel strength that measures as the quantitative target for assessing medical bio bressing adhesive strength, be easy to according to specific data come
The firmness adhered to when dressing is used with the surface of a wound is determined, also allows for carrying out definite comparison to the adhesive strength of different dressing,
Peel strength is bigger, illustrates that the viscosity of dressing is stronger.Secondly, the present invention is before peel strength is determined, first water or physiological saline
Uniformly it is sprayed on medical bio bressing, simulates and absorb diffusate or blood when dressing is contacted with the surface of a wound and wetted application
Scene, makes the peel strength measured more to embody adhesive strength of the dressing in practical application.Moreover, the viscosity inspection of the present invention
Survey that method and step is simple, testing conditions are easy to control, require low to the operation of tester, the accuracy of its testing result depends on ten thousand
The automation equipments such as energy testing machine, therefore, the stability and repeatability of the sticky detection method are more preferable.The present invention has filled up quantitative
Detect the sticky technological gap of medical bio bressing, the quality control in research and development and industrialized production to medical bio bressing
There is directive significance.
Further, the medical bio bressing is fibrin patch, collagen protein sponge, chitosan sponge dressing, oxygen
Change regenerated cellulose dressing, gelfoam dressing or adhesive fibrin.
Further, the amount that water or physiological saline are uniformly sprayed on medical bio bressing is 0.01ml/cm2~
0.05ml/cm2, the liquid-drop diameter of ejection is less than 1mm.The local overly moist of medical bio bressing or overdrying are avoided, peel strength is influenceed
Testing result.
Further, the medium that sticks is fresh animal epidermis, processing animals leather, dermatine or fabric.Stick
The material price of medium is cheap, advantageously reduces testing cost.
Further, the fresh animal micromicro is pigskin, ox-hide, sheepskin etc., and its thickness is 0.5mm~3mm, and processing is dynamic
The thickness of thing leather is 0.5mm~3mm, and the thickness of dermatine is 0.5mm~3mm, and the thickness of fabric is 0.1mm~2mm.
Further, the fabric is woven fabric or non-woven cloth.
The more flat smooth of fresh animal epidermis, processing animals leather and dermatine simulation people's body surface or animal body surface
The surface of a wound, the peel strength measured is more represented the firmness that dressing sticks with surface wound in practical application.Fabric
Out-of-flatness, the more coarse surface of a wound is simulated, such as treated liver surface of a wound makes the peel strength measured to embody dressing
The firmness sticked in practical application with the organ surface of a wound.
Further, the medical bio bressing and stick the adhesion process of medium temperature be 10 DEG C~40 DEG C, it is relative
Humidity is progress under conditions of 30%~70%.The adhesive strength of medical bio bressing can by environment temperature and humidity shadow
Ring, therefore by limiting temperature and humidity when bonding, Essential Environment condition of the simulation dressing in practical application, it is ensured that measure
Peel strength can represent adhesive strength of the dressing in practical application.
Further, it is 0.5min~90min the time required to adhesion process of the medical bio bressing with sticking medium.
When medical bio bressing is contacted with the surface of a wound, its viscosity would generally increase with the extension with surface of a wound time of contact, until reaching
Maximum.Therefore, by limiting the time bonded, it is ensured that medical bio bressing is fully bonded with sticking medium, makes the stripping measured
Greatest viscosity can be represented from intensity, the standard for weighing dressing viscosity can be used as.
Further, universal testing machine or the peeling strength test machine determines medical bio with 180 ° of peel angle and applied
Expect and stick the peel strength of medium.
Further, universal testing machine or the peeling strength test machine determines medical bio bressing and sticks the stripping of medium
During from intensity, draw speed used is 200mm/min~400mm/min.By selecting suitable draw speed, it is ensured that omnipotent
Testing machine or peeling strength test function measure accurate and effective stripping curve, are conducive to obtaining accurate peel strength detection
As a result.
Embodiment
Example one：Fibrin patch viscosity detection
Medical bio bressing to be measured：Fibrin patch is (wide：4.5cm, it is long：9.0cm).
Stick medium：Wash cotton (thickness：0.5mm).
Equipment and reagent：Breadboard (stainless steel, it is thick：1.6mm~1.9mm, it is long：150mm ± 1mm, it is wide：50mm±
1mm), peeling strength test machine (model BLD-1028, the production of Dongguan Bo Laide experimental instruments and equipment limiteds), disposable nothing
(the upper husky watt medical courses in general industry of dried shrimps is limited for shower nozzle in bacterium syringe (specification is 2.5ml), disposable sterile duplex medicament-mixing bag
Company produce), weight roller, deionized water, double faced adhesive tape.
Sticky detection method is as follows：
First, the backing that fibrin is pasted is fixed on breadboard with double faced adhesive tape, the tested surface court for pasting fibrin
On.Then, 2.3ml deionized waters are drawn with syringe, 0.05ml/cm is pressed by shower nozzle2Injection flow rate be uniformly sprayed at fiber egg
Stick in vain, shower nozzle is 15cm with the distance that fibrin is pasted, and the drop diameter of ejection is less than 1mm, in mist-like, it is impossible to make fiber
The local overly moist of albumen patch or overdrying.Then, the small cardiosymphysis of tested surface that cotton is pasted with fibrin is washed in water intaking, is pressed lightly on and is smoothed
Bonding place, then roll with weight roller bonding place back and forth 3~5 times, then temperature be 25 DEG C ± 3 DEG C, humidity be 55% ± 5%
Under the conditions of stand 30min.Finally, 180 ° of the free end doubling of cotton, then free end and the breadboard that cotton will be washed will be washed
It is upper and lower respectively to be held on testing machine, release surface is consistent with testing machine line, confirm install it is errorless after, testing machine with
300mm/min ± 10mm/min speed, which rises, realizes continuous stripping, and draws stripping curve, and processing obtains testing result.
Viscosity of the present embodiment respectively to three fibrin patches is detected that the mean peel strength measured is
243.27gf/cm, relative standard deviation RSD are 5.6%.
Example two：Fibrin patch viscosity detection
Medical bio bressing to be measured：Fibrin patch is (wide：4.5cm, it is long：9.0cm).
Stick medium：Dermatine (thickness：1mm).
Equipment and reagent：Breadboard (stainless steel, it is thick：1.6mm~1.9mm, it is long：150mm ± 1mm, it is wide：50mm±
1mm), peeling strength test machine (model BLD-1028, the production of Dongguan Bo Laide experimental instruments and equipment limiteds), disposable nothing
Shower nozzle (upper husky watt of limited public affairs of medical courses in general industry of dried shrimps in bacterium syringe (specification is 1ml), disposable sterile duplex medicament-mixing bag
Department production), weight roller, deionized water, double faced adhesive tape.
Sticky detection method is as follows：
First, the backing that fibrin is pasted is fixed on breadboard with double faced adhesive tape, the tested surface court for pasting fibrin
On.Then, 0.5ml deionized waters are drawn with syringe, 0.01ml/cm is pressed by shower nozzle2Injection flow rate be uniformly sprayed at fiber egg
Stick in vain, shower nozzle is 20cm with the distance that fibrin is pasted, and the drop diameter of ejection is less than 1mm, in mist-like, it is impossible to make fiber
The local overly moist of albumen patch or overdrying.Then, the small cardiosymphysis of tested surface for taking dermatine to be pasted with fibrin, presses lightly on and smooths
Bonding place, then roll with weight roller bonding place back and forth 3~5 times, then temperature be 20 DEG C ± 2 DEG C, humidity be 60% ± 5%
Under the conditions of stand 10min.Finally, by 180 ° of the free end doubling of dermatine, then by the free end of dermatine and breadboard
It is upper and lower respectively to be held on testing machine, release surface is consistent with testing machine line, confirm install it is errorless after, testing machine with
250mm/min ± 10mm/min speed, which rises, realizes continuous stripping, and draws stripping curve, and processing obtains testing result.
Viscosity of the present embodiment respectively to three fibrin patches is detected that the mean peel strength measured is
219.13gf/cm, relative standard deviation RSD are 6.0%.
Example three：Collagen protein sponge viscosity detection
Medical bio bressing to be measured：Collagen protein sponge is (wide：4.0cm, it is long：10.0cm).
Stick medium：Non-woven fabrics (thickness：0.3mm).
Equipment and reagent：Breadboard (stainless steel, it is thick：1.6mm~1.9mm, it is long：150mm ± 1mm, it is wide：50mm±
1mm), peeling strength test machine (model BLD-1028, the production of Dongguan Bo Laide experimental instruments and equipment limiteds), disposable nothing
Shower nozzle (upper husky watt of limited public affairs of medical courses in general industry of dried shrimps in bacterium syringe (specification is 1ml), disposable sterile duplex medicament-mixing bag
Department production), weight roller, deionized water, double faced adhesive tape.
Sticky detection method is as follows：
First, the backing of collagen protein sponge is fixed on breadboard with double faced adhesive tape, makes the to be measured of collagen protein sponge
Up.Then, 0.5ml deionized waters are drawn with syringe, 0.01ml/cm is pressed by shower nozzle2Injection flow rate be uniformly sprayed at glue
In former protein sponge, the distance of shower nozzle and collagen protein sponge is 20cm, and the drop diameter of ejection is less than 1mm, in mist-like, no
The local overly moist of collagen protein sponge or overdrying can be made.Then, the small cardiosymphysis of tested surface of non-woven fabrics and collagen protein sponge is taken, gently
Light press smooths bonding place, then rolls with weight roller bonding place back and forth 3~5 times, then temperature be 30 DEG C ± 3 DEG C, humidity be
60min is stood under conditions of 55% ± 10%.Finally, by 180 ° of the free end doubling of non-woven fabrics, then by the free end of non-woven fabrics
With breadboard is upper and lower respectively is held on testing machine, release surface is consistent with testing machine line, confirm to install it is errorless after, examination
Test machine and the continuous stripping of realization is risen with 250mm/min ± 10mm/min speed, and draw stripping curve, processing obtains detection and tied
Really.
Viscosity of the present embodiment respectively to three collagen protein sponges is detected that the mean peel strength measured is
92.26gf/cm, relative standard deviation RSD are 5.4%.
Example four：Chitosan sponge dressing viscosity detection
Medical bio bressing to be measured：Chitosan biological sponge dressing is (wide：4.5cm, it is long：9cm).
Stick medium：(surfacing, deoils fresh porcine skin, thickness：2.5mm).
Equipment and reagent：Breadboard (stainless steel, it is thick：1.6mm~1.9mm, it is long：150mm ± 1mm, it is wide：50mm±
1mm), peeling strength test machine (model BLD-1028, the production of Dongguan Bo Laide experimental instruments and equipment limiteds), disposable nothing
Shower nozzle (upper husky watt of limited public affairs of medical courses in general industry of dried shrimps in bacterium syringe (specification is 1ml), disposable sterile duplex medicament-mixing bag
Department production), weight roller, deionized water, double faced adhesive tape.
Sticky detection method is as follows：
First, the backing of chitosan biological sponge dressing is fixed on breadboard with double faced adhesive tape, makes chitosan biological sea
Continuous dressing it is to be measured up.Then, 1ml deionized waters are drawn with syringe, 0.02ml/cm is pressed by shower nozzle2Injection flow rate it is equal
Even to be sprayed on chitosan biological sponge dressing, the distance of shower nozzle and chitosan biological sponge dressing is 18cm, the water droplet of ejection
Diameter is less than 1mm, in mist-like, it is impossible to make the local overly moist of chitosan biological sponge dressing or overdrying.Then, take fresh porcine skin with
The small cardiosymphysis of tested surface of chitosan biological sponge dressing, presses lightly on and smooths bonding place, then roll bonding back and forth with weight roller
Place 3~5 times, then temperature be 25 DEG C ± 2 DEG C, humidity be to stand 5min under conditions of 55% ± 5%.Finally, by fresh pig
180 ° of the free end doubling of skin, then be held on the free end of fresh porcine skin and breadboard are upper and lower respectively on testing machine, make stripping
Face is consistent with testing machine line, after confirming that installation is errorless, and testing machine is risen with 350mm/min ± 10mm/min speed to be realized
It is continuous to peel off, and stripping curve is drawn, processing obtains testing result.
Viscosity of the present embodiment respectively to three chitosan biological sponge dressings is detected that the average stripping measured is strong
Spend for 92.01gf/cm, relative standard deviation RSD is 4.3%.
Example five：Gelfoam viscosity detection
Medical bio bressing to be measured：Absorbable gelatin sponge is (wide：4.5cm, it is long：8cm, thickness：0.5cm).
Stick medium：(surfacing, deoils fresh ox-hide, thickness：2mm).
Equipment and reagent：Breadboard (stainless steel, it is thick：1.6mm~1.9mm, it is long：150mm ± 1mm, it is wide：50mm±
1mm), peeling strength test machine (model BLD-1028, the production of Dongguan Bo Laide experimental instruments and equipment limiteds), disposable nothing
Shower nozzle (upper husky watt of limited public affairs of medical courses in general industry of dried shrimps in bacterium syringe (specification is 1ml), disposable sterile duplex medicament-mixing bag
Department production), weight roller, physiological saline, double faced adhesive tape.
Sticky detection method is as follows：
First, the backing of gelfoam is fixed on breadboard with double faced adhesive tape, makes the to be measured face-up of gelfoam.So
Afterwards, 0.9ml physiological saline is drawn with syringe, 0.02ml/cm is pressed by shower nozzle2Injection flow rate be uniformly sprayed on gelfoam,
The distance of shower nozzle and gelfoam is 18cm, and the drop diameter of ejection is less than 1mm, in mist-like, it is impossible to make gelfoam local
Overly moist or overdrying.Then, the small cardiosymphysis of tested surface of fresh ox-hide and gelfoam is taken, presses lightly on and smooths bonding place, then use
Weight roller rolls bonding place 3~5 times back and forth, then temperature be 15 DEG C ± 3 DEG C, humidity be standing under conditions of 50% ± 10%
90min.Finally, by 180 ° of the free end doubling of fresh ox-hide, then the free end of fresh ox-hide and breadboard distinguished into upper and lower folder
Be held on testing machine, release surface is consistent with testing machine line, confirm install it is errorless after, testing machine with 350mm/min ±
10mm/min speed, which rises, realizes continuous stripping, and draws stripping curve, and processing obtains testing result.
Viscosity of the present embodiment respectively to three gelfoams is detected that the mean peel strength measured is
45.80gf/cm, relative standard deviation RSD are 3.9%.
Embodiment described above only expresses the several embodiments of the present invention, and it describes more specific and detailed, but simultaneously
Can not therefore it be construed as limiting the scope of the patent.It should be pointed out that coming for one of ordinary skill in the art
Say, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present invention
Scope.
Claims (10)
1. the sticky detection method of a kind of medical bio bressing, it is characterised in that comprise the following steps：
Medical bio bressing is fixed on breadboard, then water or physiological saline are uniformly sprayed on medical bio bressing,
Take again and stick medium and medical bio bressing bonding, then determining medical bio with universal testing machine or peeling strength test machine applies
Expect and stick the peel strength after medium bonding.
2. the sticky detection method of medical bio bressing according to claim 1, it is characterised in that：The medical bio is applied
Expect for fibrin patch, collagen protein sponge, chitosan sponge dressing, oxidized regenerated cellulose dressing, gelfoam dressing or
Adhesive fibrin.
3. the sticky detection method of medical bio bressing according to claim 1, it is characterised in that：Water or physiological saline are equal
The even amount being sprayed on medical bio bressing is 0.01ml/cm2~0.05ml/cm2, the liquid-drop diameter of ejection is less than 1mm.
4. the sticky detection method of medical bio bressing according to claim 1, it is characterised in that：The medium that sticks is
Fresh animal epidermis, processing animals leather, dermatine or fabric.
5. the sticky detection method of medical bio bressing according to claim 4, it is characterised in that：The fresh animal skin
Thickness be 0.5mm~3mm, the thickness of processing animals leather is 0.5mm~3mm, and the thickness of dermatine is 0.5mm~3mm,
The thickness of fabric is 0.1mm~2mm.
6. the sticky detection method of medical bio bressing according to claim 4, it is characterised in that：The fabric is woven
Cloth or non-woven cloth.
7. the sticky detection method of medical bio bressing according to claim 1, it is characterised in that：The medical bio is applied
Expect and stick the adhesion process of medium temperature be 10 DEG C~40 DEG C, relative humidity be progress under conditions of 30%~70%.
8. the sticky detection method of medical bio bressing according to claim 7, it is characterised in that：The medical bio is applied
The adhesion process required time expected and stick medium is 0.5min~90min.
9. the sticky detection method of medical bio bressing according to claim 1, it is characterised in that：The universal testing machine
Or peeling strength test machine determines medical bio bressing with 180 ° of peel angle and sticks the peel strength of medium.
10. the sticky detection method of medical bio bressing according to claim 9, it is characterised in that：The universal test
When machine or peeling strength test machine determine medical bio bressing and stick the peel strength of medium, draw speed used is
200mm/min~400mm/min.
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| CN201710366770.1A CN107228824B (en) | 2017-05-23 | 2017-05-23 | Method for detecting viscosity of medical biological dressing |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108072605A (en) * | 2017-11-27 | 2018-05-25 | 惠州拓邦电气技术有限公司 | A kind of test method of electrodes of lithium-ion batteries peel strength |
| CN110095408A (en) * | 2018-01-30 | 2019-08-06 | 香港理工大学 | The viscosity test device and test method of textile and skin |
| CN110095408B (en) * | 2018-01-30 | 2023-01-03 | 香港理工大学 | Method for testing viscosity of textile and skin |
| CN112088297A (en) * | 2018-03-22 | 2020-12-15 | 西兰丁姆医疗公司 | Method for determining adhesion of hemostatic tissue sealant patch |
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| JP7227341B2 (en) | 2018-03-22 | 2023-02-21 | シーレーンチウム メディカル リミテッド | Method for Measuring Adhesion of Hemostatic Tissue Sealant Patches |
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