CN203561576U - Device for measuring bioadhesion in vitro of bioadhesion preparation - Google Patents
Device for measuring bioadhesion in vitro of bioadhesion preparation Download PDFInfo
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- CN203561576U CN203561576U CN201320673633.XU CN201320673633U CN203561576U CN 203561576 U CN203561576 U CN 203561576U CN 201320673633 U CN201320673633 U CN 201320673633U CN 203561576 U CN203561576 U CN 203561576U
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Abstract
The utility model provides a device for measuring the bioadhesion in vitro of a bioadhesion preparation. The device comprises a fixed platform which is provided with a force measuring instrument and a two-dimension moving platform; the two-dimension moving platform is provided with a bonding region for holding bioadhesion materials; in testing, one side of the bioadhesion preparation is connected with the bioadhesion materials in the bonding region, and the other side of the bioadhesion preparation is connected with the force measuring instrument. The device for measuring the bioadhesion in vitro of the bioadhesion preparation has the advantages of low expense, intuitive and reliable result, capability of processing a plurality of samples once, simplicity and rapidity in operation, good reproducibility, high precision and the like, and is suitable for measurement on the bioadhesion of bioadhesion materials.
Description
Technical field
The utility model belongs to System In Pharmaceutical Preparation Analysis technical field of measurement and test, relates to a kind of device of measuring biologic adhesion preparation external biological adhesion.
Background technology
Biologic adhesion preparation is the more Novel Drug Delivery Systems of Recent study, many macromolecular materials and biological slime or body tissue mucomembranous surface interact, can produce the clinging power of long period, be called bioadhesion, people are successfully applied to oral cavity by some bioadhesive drug delivery system at present, nasal cavity, rectum, uterus and vagina etc., this type of preparation can be made into tablet, film, gel, the multiple formulation such as stylus, adhere to human oral cavity, nasal cavity, intestines and stomach, the specific regions such as vagina, by the transhipment delivering medicament of mucous membrane, reach the effect of whole body or topical therapeutic, to reach target administration, the action time of prolong drug, control the release rate of medicine, alleviate the toxic and side effect of medicine, improve the object of drug bioavailability, and obtained obvious effect.Tablet technique is simple, and volume is little, and it is convenient to use, store, and controlled-release effect is good, is formulation the most frequently used in biologic adhesion preparation.
Late 1970s, it is the carrier of steroidal anti-inflammatory drugs that Nagai adopts adhesion polymkeric substance first, topical treatment aphtha, obtain good result for the treatment of, after this biologic adhesion preparation obtains extensive concern, wherein adhesive tablet is most widely used formulation, at present in the U.S., mucous membrane of mouth adhesion preparation goes on the market in succession, be useful on the testosterone mouth cheek sheet for the treatment of male sexual hypofunction disease, for the Miconazole mouth cheek sheet of anti-fungal infection, for medicines such as analgesic fentanyl mouth cheek sheets, domestic also have an amlexanox, the mouth paster listings such as metronidazole, the bioadhesive drug delivery system market share is progressively growing trend.
Bioadhesion power refers to the completely separation required maximum, force of adhesion material and mucous membrane, and the size of adhesion has determined the absorption of medicine and the action time of medicine, therefore the mensuration of adhesion size is had great importance.But in Chinese Pharmacopoeia, there is no a mouthful assay method for cheek sheet bioadhesion in vitro at present, only has the assay method of patch adhesion, in pharmacopeia, the mensuration of adhesion is weighed by three indexs, just viscous force, hold viscous force and peel strength, domestic and foreign literature all adopts the measurement index of peel strength as adhesion, all adopt homemade bioadhesion power apparatus to measure the bioadhesion power of each prescription, install simple and crude, accuracy and repeatability are poor, lack accuracy, can not serve as the standard of weighing bioadhesion power.
Utility model content
The technical matters that the utility model solves is to provide a kind of device of measuring biologic adhesion preparation external biological adhesion, can accurately measure the bioadhesion in vitro of biologic adhesion preparation.
The utility model is to be achieved through the following technical solutions:
A device of measuring biologic adhesion preparation external biological adhesion, is characterized in that, comprises stationary platform, and the two-dimensional movement platform that stationary platform is provided with dynamometry instrument and can moves is provided with the sticking area of placing bioadhesive material on two-dimensional movement platform; When test, biologic adhesion preparation one side is connected with the bioadhesive material on sticking area, and a side is connected with dynamometer.
Described two-dimensional movement stand is established in orbit, after being driven along track up and down or move left and right.
Described two-dimensional movement platform is manual actuation, or connection drive motor drives.
The sticking area of described two-dimensional movement platform is provided with is convenient to the fixing hole of bioadhesive material or projection.
Maximum, force when described dynamometry instrument record adhesion preparation is separation with bioadhesive material, and show.
Described dynamometry instrument is dynamometer, and tautness meter or thrust meter are also connected with computing machine by efficiency conversion device or power energy converter, send to computing machine to carry out quantitatively in real time its measurement result by converter.
Compared with prior art, the utlity model has following useful technique effect:
The device of the measurement biologic adhesion preparation external biological adhesion that the utility model provides, required bioadhesive material (such as mucous membrane) can be fixed on two-dimensional movement platform, the one side of measured biologic adhesion preparation (such as adhesion tablet) is connected with two-dimensional movement platform, one side is connected with dynamometer, by the movement of two-dimensional movement platform, realize the separation of biologic adhesion preparation and bioadhesive material, record the maximum, force of biologic adhesion preparation when separation with bioadhesive material, be bioadhesion power.
The device of the measurement biologic adhesion preparation external biological adhesion that the utility model provides, expense is cheap, and visual result is reliable, the multiple samples of energy single treatment, have simple to operate, rapid, favorable reproducibility, precision advantages of higher, is suitable for the mensuration of bioadhesive material.
Accompanying drawing explanation
Fig. 1 is structural representation of the present utility model;
Wherein: 1 is dynamometry instrument; 2 is stationary platform; 3 is two-dimensional movement platform.
Embodiment
Below in conjunction with accompanying drawing, the utility model is described in further detail, described in be to explanation of the present utility model rather than restriction.
Referring to Fig. 1, a kind of device of measuring biologic adhesion preparation external biological adhesion, comprises stationary platform 2, and the two-dimensional movement platform 3 that stationary platform 2 is provided with dynamometry instrument 1 and can moves is provided with the sticking area of placing bioadhesive material on two-dimensional movement platform 3; When test, biologic adhesion preparation one side is connected with the bioadhesive material on sticking area, and a side is connected with dynamometry instrument 1.
Concrete, described two-dimensional movement platform 3 sets up in orbit, when receiving after driving along rail moving.And described two-dimensional movement platform 3 also can be connected with the motor or the handwheel that drive, by such as stepper motor, the connection of common electric machine etc., makes automatic or manual two-dimensional movement platform, easy to operate.
The sticking area of described two-dimensional movement platform 3 is provided with is convenient to the fixing hole of mucosal bioadhesive material or projection.Such as, on two-dimensional movement platform, can do suitable processing such as beating circular hole etc., so that immobile mucosa or preparation facilitate continued operation.
Maximum, force when described dynamometry instrument record adhesion preparation is separation with bioadhesive material, and show.Or described dynamometer also can be connected with computing machine by efficiency conversion device, dynamometer sends to computing machine by efficiency conversion device in real time by its measurement result; By computing machine, carry out quantitative (such as can checking record value or record value being depicted as to curve, its top is maximum, force, is also bioadhesion power) of maximum, force.Concrete, dynamometry instrument can be tautness meter, dynamometer etc., and its converter such as energy converter, efficiency conversion device of can exerting oneself is connected with computing machine.
Concrete, in the device of above-mentioned measurement biologic adhesion preparation external biological adhesion, stationary platform material can be selected such as poly (methyl methacrylate) plate, plastic plate, the surface plate that silica gel plate etc. can be fixing, preferably silica gel plate.And two-dimensional movement platform can be used the smooth plate of any material.
The device of measuring biologic adhesion preparation external biological adhesion, the operation when measuring is as follows:
Required biomembrane material is fixed on two-dimensional movement platform, the one side of measured adhesion tablet and dynamometer part are connected and fixed, the adhesion tablet another side of required mensuration is wetting with manual simulation's biological fluid, contact a period of time with biomembrane material compressing, start two-dimensional movement platform, record the maximum, force of adhesion tablet when separation with bioadhesive material, be bioadhesion power.
The mensuration embodiment that provides a kind of concrete bioadhesion power below, comprises following operation:
(1) preparation of Fluconazole oral cavity adherent emplastrum: get the auxiliary material that appropriate Fluconazole adds corresponding proportion, mix, compressing tablet.
(2) oral mucosa of rabbit is firmly pasted on to the sticking area on two-dimensional movement platform with xanthan gum, one side of Fluconazole oral cavity adherent emplastrum to be measured is wetting with a small amount of artificial saliva, be covered in rapidly on rabbit mucous membrane, make sticking tablet and mucous membrane close contact, apply respectively external force 1.5N simultaneously, 1.0N, 0.5N, 0.3N and 0.1N, continue 3 minutes, after 3 minutes, remove external force, start two-dimensional movement platform, record the registration of dynamometer, be the external biological adhesion (in 6) of adhesion tablet.
(3) measurement result of Fluconazole external biological adhesion is as shown in the table:
| Apply external force (N) | 1.5 | 1.0 | 0.5 | 0.3 | 0.1 |
| Bioadhesion in vitro (g) | 100.5 | 76.9 | 42.3 | 29.7 | 20.4 |
Or carry out following measurement:
(1) preparation of Fluconazole oral cavity adherent emplastrum: get the auxiliary material that appropriate Fluconazole adds corresponding proportion, mix, compressing tablet.
(2) oral mucosa of rabbit is firmly pasted on to the sticking area on two-dimensional movement platform with xanthan gum, a side of Fluconazole oral cavity adherent emplastrum to be measured is wetting with a small amount of artificial saliva, be covered in rapidly on rabbit mucous membrane, make sticking tablet and mucous membrane close contact, 0.5N, continues 3 minutes respectively, 5 minutes, 10 minutes, 20 minutes, after 30 minutes, remove external force, start two-dimensional movement platform, record the registration of dynamometer, be the external biological adhesion (in 6) of adhesion tablet.
(3) measurement result of Fluconazole external biological adhesion is as shown in the table:
| Duration (min) | 3 | 5 | 10 | 20 | 30 |
| Bioadhesion in vitro (g) | 42.3 | 49.1 | 61.8 | 68.5 | 73.4 |
The device of the measurement biologic adhesion preparation external biological adhesion that the utility model provides, expense is cheap, especially adopting computing machine to carry out reading of maximum, force, be that result is more intuitive and reliable, and the multiple samples of energy single treatment, have simple to operate, rapidly, favorable reproducibility, precision advantages of higher, is suitable for the mensuration of the bioadhesion power of bioadhesive material.
Claims (6)
1. measure the device of biologic adhesion preparation external biological adhesion for one kind, it is characterized in that, comprise stationary platform (2), the two-dimensional movement platform (3) that stationary platform (2) is provided with dynamometry instrument (1) and can moves, is provided with the sticking area of placing bioadhesive material on two-dimensional movement platform (3); When test, biologic adhesion preparation one side is connected with the bioadhesive material on sticking area, and a side is connected with dynamometer (1).
2. the device of measurement biologic adhesion preparation external biological adhesion as claimed in claim 1, is characterized in that, described two-dimensional movement platform (3) sets up in orbit, after being driven along track up and down or move left and right.
3. the device of measurement biologic adhesion preparation external biological adhesion as claimed in claim 2, is characterized in that, described two-dimensional movement platform (3) is manual actuation, or connection drive motor drives.
4. the device of measurement biologic adhesion preparation external biological adhesion as claimed in claim 1, is characterized in that, the sticking area of described two-dimensional movement platform (3) is provided with is convenient to the fixing hole of bioadhesive material or projection.
5. the device of measurement biologic adhesion preparation external biological adhesion as claimed in claim 1, is characterized in that, described dynamometry instrument (1) records the maximum, force of adhesion preparation when separation with bioadhesive material, and shows.
6. the device of measurement biologic adhesion preparation external biological adhesion as claimed in claim 1, it is characterized in that, described dynamometry instrument is dynamometer, tautness meter or thrust meter, also by efficiency conversion device or power energy converter, be connected with computing machine, by converter, send to computing machine to carry out quantitatively in real time its measurement result.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320673633.XU CN203561576U (en) | 2013-10-28 | 2013-10-28 | Device for measuring bioadhesion in vitro of bioadhesion preparation |
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|---|---|---|---|
| CN201320673633.XU CN203561576U (en) | 2013-10-28 | 2013-10-28 | Device for measuring bioadhesion in vitro of bioadhesion preparation |
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| CN203561576U true CN203561576U (en) | 2014-04-23 |
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| CN201320673633.XU Expired - Fee Related CN203561576U (en) | 2013-10-28 | 2013-10-28 | Device for measuring bioadhesion in vitro of bioadhesion preparation |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105181579A (en) * | 2015-08-12 | 2015-12-23 | 成都医学院 | Instrument for determination of adhesive force and application thereof |
| CN107228824A (en) * | 2017-05-23 | 2017-10-03 | 广州市众为生物技术有限公司 | A kind of sticky detection method of medical bio bressing |
| CN107490541A (en) * | 2016-06-12 | 2017-12-19 | 武汉武药科技有限公司 | Paste the detection means and detection method of piece adhesion property in oral cavity |
| CN109470631A (en) * | 2017-09-08 | 2019-03-15 | 东洋橡胶工业株式会社 | The adhesive test method of rubber and the adhesive test system of rubber |
| CN111929235A (en) * | 2020-08-12 | 2020-11-13 | 赛轮集团股份有限公司 | Apparatus and method for testing tire label adhesion |
| EP4050324A4 (en) * | 2020-12-30 | 2022-08-31 | China Tobacco Yunnan Industrial Co., Ltd | Test system and test method for lip sticking force of tipping paper for cigarettes |
| RU2796420C1 (en) * | 2020-12-30 | 2023-05-23 | Чайна Табакко Юньнань Индастриал Ко., Лтд | Testing system and method for testing force of adhesion of cigarette tip paper to lips |
-
2013
- 2013-10-28 CN CN201320673633.XU patent/CN203561576U/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105181579A (en) * | 2015-08-12 | 2015-12-23 | 成都医学院 | Instrument for determination of adhesive force and application thereof |
| CN105181579B (en) * | 2015-08-12 | 2018-05-29 | 成都医学院 | A kind of instrument for measuring adhesive force and its application |
| CN107490541A (en) * | 2016-06-12 | 2017-12-19 | 武汉武药科技有限公司 | Paste the detection means and detection method of piece adhesion property in oral cavity |
| CN107228824A (en) * | 2017-05-23 | 2017-10-03 | 广州市众为生物技术有限公司 | A kind of sticky detection method of medical bio bressing |
| CN109470631A (en) * | 2017-09-08 | 2019-03-15 | 东洋橡胶工业株式会社 | The adhesive test method of rubber and the adhesive test system of rubber |
| CN111929235A (en) * | 2020-08-12 | 2020-11-13 | 赛轮集团股份有限公司 | Apparatus and method for testing tire label adhesion |
| EP4050324A4 (en) * | 2020-12-30 | 2022-08-31 | China Tobacco Yunnan Industrial Co., Ltd | Test system and test method for lip sticking force of tipping paper for cigarettes |
| RU2796420C1 (en) * | 2020-12-30 | 2023-05-23 | Чайна Табакко Юньнань Индастриал Ко., Лтд | Testing system and method for testing force of adhesion of cigarette tip paper to lips |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140423 Termination date: 20151028 |
|
| EXPY | Termination of patent right or utility model |