CN107183473A - A kind of sealwort Semen sesami nigrum effervescence granular - Google Patents
A kind of sealwort Semen sesami nigrum effervescence granular Download PDFInfo
- Publication number
- CN107183473A CN107183473A CN201710381530.9A CN201710381530A CN107183473A CN 107183473 A CN107183473 A CN 107183473A CN 201710381530 A CN201710381530 A CN 201710381530A CN 107183473 A CN107183473 A CN 107183473A
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- parts
- sealwort
- semen sesami
- sesami nigrum
- raw material
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- 210000000582 semen Anatomy 0.000 title claims abstract description 41
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 49
- 239000002994 raw material Substances 0.000 claims abstract description 45
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
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- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims abstract description 24
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- 239000000463 material Substances 0.000 claims abstract description 22
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract description 21
- 239000004378 Glycyrrhizin Substances 0.000 claims abstract description 20
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims abstract description 20
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- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims abstract description 20
- 235000019410 glycyrrhizin Nutrition 0.000 claims abstract description 20
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 20
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- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 claims description 13
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- 206010013954 Dysphoria Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
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- 241000218231 Moraceae Species 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
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- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/40—Effervescence-generating compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
- Confectionery (AREA)
Abstract
A kind of sealwort Semen sesami nigrum effervescence granular, is prepared from by the raw material and auxiliary material of following parts by weight：Raw material：40 60 parts of sealwort, 20 40 parts of Semen sesami nigrum, 18 22 parts of mulberry fruit, 25 35 parts of matrimony vine, 8 12 parts of jujube kernel, 8 12 parts of radish seed, 58 parts of the bark of official magnolia, 12 16 parts of the fruit of glossy privet；Auxiliary material：45 50 parts of citric acid, 45 50 parts of saleratus, 150 200 parts of maltodextrin, 20 26 parts of Macrogol 4000,0.5 1 parts of glycyrrhizin, 57 parts of fructose.Without caking under the conditions of effervescence granular prepared by the present invention is long time stored, rapid dissolving after adding water, and also dissolving is complete, noresidue, the bad smell of Chinese medicine can be covered, with good palatability, with significant filling liver kidney, black beard and hair, antitoxic heart-soothing and sedative, promote the production of body fluid to quench thirst, tranquilize the mind and promote the intelligence function.
Description
Technical field
The invention belongs to food processing technology field, and in particular to a kind of sealwort Semen sesami nigrum effervescence granular and its preparation side
Method.
Background technology
With the quickening and increasing environmental pollution of modern life rhythm, many people especially the elderly, sitting office
City white collar and student be suffering from the not enough illness of hepatic and renal function, be mainly shown as dizziness, fatigue, poliosis, xerophtalmia,
The symptom such as soreness and weakness of waist and knees, being irritable and getting angry easily, dysphoria in chestpalms-soles, there is no clear and definite treatment method and targeted drug at present.
Effervesce is a kind of new formulation developed in recent years, is made up of raw material and disintegrant, and effervesce can accelerate disintegration
With dissolve, improve bioavilability, feed change taste itself, improve mouthfeel, take into account the advantage of liquid preparation and solid pharmaceutical preparation,
And effervescent tablet only has Vc effervescent tablets in the market, less several such as effervescent tablet of replenishing the calcium, aspirin effervescent tablet, not pin
The effervescent formulation used the not enough crowd of hepatic and renal function.
The content of the invention
The purpose of the present invention be that for solve the deficiencies in the prior art provide it is a kind of there is filling liver kidney, it is black beard and hair, peaceful
Heart and tranquilizing mind, promote the production of body fluid to quench thirst, the sealwort Semen sesami nigrum effervescence granular of tranquilize the mind and promote the intelligence function.
The purpose of the present invention is realized with following technical proposals：
A kind of sealwort Semen sesami nigrum effervescence granular, is prepared from by the raw material and auxiliary material of following parts by weight：
Raw material：40-60 parts of sealwort, 20-40 parts of Semen sesami nigrum, 18-22 parts of mulberry fruit, 25-35 parts of matrimony vine, 8-12 parts of jujube kernel, Lay
8-12 parts of Fu, 5-8 parts of the bark of official magnolia, 12-16 parts of the fruit of glossy privet；
Auxiliary material：45-50 parts of citric acid, 45-50 parts of saleratus, 150-200 parts of maltodextrin, Macrogol 4000 20-
26 parts, 0.5-1 parts of glycyrrhizin, 5-7 parts of fructose.
It is preferred that, it is prepared from by the raw material of following parts by weight：
Raw material：50 parts of sealwort, 30 parts of Semen sesami nigrum, 20 parts of mulberry fruit, 30 parts of matrimony vine, 10 parts of jujube kernel, 10 parts of radish seed, the bark of official magnolia
6.5 parts, 14 parts of the fruit of glossy privet；
Auxiliary material：47.5 parts of citric acid, 47.5 parts of saleratus, 175 parts of maltodextrin, 23 parts of Macrogol 4000, radix glycyrrhizae
0.75 part of glucin, 6 parts of fructose.
The preparation method of sealwort Semen sesami nigrum effervescence granular as described above, comprises the following steps：
(1) prepared by raw material extraction stiff paste：Above-mentioned raw materials are taken to add water extraction, filtering takes filtrate to be concentrated into relative density to be
1.25-1.35 medicinal extract, it is standby；
(2) preparation of acid particles：Take whole citric acids, all 45-55% of whole maltodextrin weight, poly- second two
45-55%, the 45-55% of all fructose weight of alcohol, whole glycyrrhizin weight；The 45-55% of medicinal extract total amount is added, with water
For wetting agent, softwood is made, then using wet granulation, is dried under the conditions of 40-60 DEG C to water content and is less than 6%；
(3) preparation of alkali grain：Take whole saleratus, step (2) remaining maltodextrin, glycyrrhizin, fructose
And medicinal extract, using water as wetting agent, softwood is made, then using wet granulation, dries to water content and is less than under the conditions of 40-60 DEG C
6%；
(4) alkali grain that the acid particles and step (3) obtained step (2) is obtained is well mixed, and is produced.
Concretely comprised the following steps in step (1) and take above-mentioned raw materials plus 8-12 times of quality water to boil extraction 1.5-2h, filtering takes residue
Repeat to extract, then filter, merge filtrate twice, be concentrated into the medicinal extract that relative density is 1.25-1.35.
In inventive formulation raw material, sealwort can boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing, for deficiency of spleen-QI and stomach-QI, fatigue and asthenia,
Deficiency of stomach-Yin, dry deficiency of food, deficiency syndrome of the lung cough caused by dryness, overstrain cough hemoptysis, asthenia of essence and blood, soreness and weakness of waist and knees, poliosis, Heat Diabetes.Black sesame
Fiber crops can filling liver kidney, benefiting essence-blood, ease constipation is dry, dizzy for blood and essence asthenia, Hiccough and deaf, poliosis, post disease alopecia, intestines
Dry constipation；Mulberry fruit can nourishing yin and supplementing blood, fluid dryness, for the deficiency of liver-yin and kidney-yin, dizziness and tinnitus, palpitation and insomnia, poliosis, Tianjin wound
Yearningly, Heat Diabetes, dry constipation of intestines.Matrimony vine can be nourishing liver and kidney, benefiting shrewd head, for consumption consumptive loss, soreness of waist and knee joint, dizziness and tinnitus,
Impotence and seminal emission, Heat Diabetes, blood deficiency chlorosis, blurred vision.Jujube kernel can nourishing heart tonifying liver, antitoxic heart-soothing and sedative, arrest sweating promotes the production of body fluid, for void
Tired egersis, horrified to much dream, body void hidrosis, injury thirst.Radish seed be used for retention of food and drink, abdominal distention, can help digestion de-swelling, sending down abnormally ascending
Resolving sputum.The bark of official magnolia is used for stagnation of QI due to dyspepsia, abdominal distention constipation, damp retention in middle-jiao.The fruit of glossy privet can kidney tonifying enriching yin, nourish the liver to improve visual acuity, available for liver kidney
Deficiency, dizziness and tinnitus, graying of hair and two blurred visions are recklessly.
In above-mentioned raw materials, using sealwort and Semen sesami nigrum as major ingredient, to liver-kidney tonifying, black beard and hair；Matrimony vine, the fruit of glossy privet may help to
Enriching yin and nourishing kidney, nourish the liver to improve visual acuity；Mulberry fruit can be used for enriching blood, and jujube kernel helps nourishing heart, therefore, and matrimony vine, the fruit of glossy privet, mulberry fruit, jujube kernel can be from
Each side enhancing sealwort, effect of Semen sesami nigrum, and can be reduced caused by above-mentioned raw materials are taken excessively using radish seed magnolia obovata
The problem of abdominal distension stagnation of the circulation of vital energy；Therefore, the raw material comprehensive function of above-mentioned a variety of integration of drinking and medicinal herbs, the obtained solid beverage of preparation, which has, to be shown
The filling liver kidney of work, black beard and hair, antitoxic heart-soothing and sedative, promote the production of body fluid to quench thirst, effect of tranquilize the mind and promote the intelligence.
Mulberry fruit, matrimony vine are respectively provided with certain sweet taste, can be to a certain extent cover other raw bands come bitter taste, make bubble
The compound sweetener glycyrrhizin and fructose added when rising, can further improve mouthfeel, and glycyrrhizin is carried from radix glycyrrhizae
The glycyrrhetate obtained, with functions such as certain treatment hepatic injury, anti-oxidant and immunological regulations, the biology of enhancing raw material is living
Sexual function；The effervescence granular that citric acid is prepared as acid source dissolves rapid, while there is good flavored action, but its moisture absorption
Property also very strong, the easy sticky caking of the effervescence granular prepared；Use maltodextrin, fructose for filler and dispersant, gather
Ethylene glycol 4000 is lubricant and anticaking agent, can well prevent caking sticky.Using saleratus as alkali source, it can supplement
Blood potassium content in body, improves the symptom such as body lassitude, One's spirits are drooping, dysphoria.
Therefore, without caking under the conditions of the effervescence granular of the invention prepared can be made long time stored, rapid dissolving after adding water,
And dissolving is complete, noresidue can cover the bad smell of Chinese medicine, with good palatability, with significant filling liver kidney,
Black beard and hair, antitoxic heart-soothing and sedative, promote the production of body fluid to quench thirst, tranquilize the mind and promote the intelligence function.
Embodiment
Embodiment 1
A kind of sealwort Semen sesami nigrum effervescence granular, it is prepared from by the raw material and auxiliary material of following parts by weight：
Raw material：40-60 parts of sealwort, 20-40 parts of Semen sesami nigrum, 18-22 parts of mulberry fruit, 25-35 parts of matrimony vine, 8-12 parts of jujube kernel, Lay
8-12 parts of Fu, 5-8 parts of the bark of official magnolia, 12-16 parts of the fruit of glossy privet；
Auxiliary material：45-50 parts of citric acid, 45-50 parts of saleratus, 150-200 parts of maltodextrin, Macrogol 4000 20-
26 parts, 0.5-1 parts of glycyrrhizin, 5-7 parts of fructose.
The preparation method of above-mentioned sealwort Semen sesami nigrum effervescence granular, comprises the following steps：
(1) prepared by raw material extraction stiff paste：Above-mentioned raw materials plus 8-12 times of quality water is taken to boil extraction 1.5-2h, filtering takes residual
Slag repeats to extract, and then filters, and merges filtrate twice, is concentrated into the medicinal extract that relative density is 1.25-1.35, standby；
(2) preparation of acid particles：Take whole citric acids, all 45-55% of whole maltodextrin weight, poly- second two
45-55%, the 45-55% of all fructose weight of alcohol, whole glycyrrhizin weight；The 45-55% of medicinal extract total amount is added, with water
For wetting agent, softwood is made, then using wet granulation, is dried under the conditions of 40-60 DEG C to water content and is less than 6%；
(3) preparation of alkali grain：Take whole saleratus, step (2) remaining maltodextrin, glycyrrhizin, fructose
And medicinal extract, using water as wetting agent, softwood is made, then using wet granulation, dries to water content and is less than under the conditions of 40-60 DEG C
6%；
(4) alkali grain that the acid particles and step (3) obtained step (2) is obtained is well mixed, and is produced.
Embodiment 2
A kind of sealwort Semen sesami nigrum effervescence granular, it is prepared from by the raw material and auxiliary material of following parts by weight：
Raw material：50 parts of sealwort, 30 parts of Semen sesami nigrum, 20 parts of mulberry fruit, 30 parts of matrimony vine, 10 parts of jujube kernel, 10 parts of radish seed, the bark of official magnolia
6.5 parts, 14 parts of the fruit of glossy privet；
Auxiliary material：47.5 parts of citric acid, 47.5 parts of saleratus, 175 parts of maltodextrin, 23 parts of Macrogol 4000, radix glycyrrhizae
0.75 part of glucin, 6 parts of fructose.
The preparation method of above-mentioned sealwort Semen sesami nigrum effervescence granular, comprises the following steps：
(1) prepared by raw material extraction stiff paste：Above-mentioned raw materials plus 10 times of quality water are taken to boil extraction 105min, filtering takes residue
Repeat to extract, then filter, merge filtrate twice, be concentrated into the medicinal extract that relative density is 1.30, it is standby；
(2) preparation of acid particles：Take whole citric acids, the 50% of whole maltodextrin weight, it is whole polyethylene glycol, complete
50%, the 50% of all fructose weight of portion's glycyrrhizin weight；The 50% of medicinal extract total amount is added, using water as wetting agent, is made
Softwood, then using wet granulation, dries to water content under the conditions of 50 DEG C and is less than 6%；
(3) preparation of alkali grain：Take whole saleratus, step (2) remaining maltodextrin, glycyrrhizin, fructose
And medicinal extract, using water as wetting agent, softwood is made, then using wet granulation, dries to water content and is less than under the conditions of 50 DEG C
6%；
(4) alkali grain that the acid particles and step (3) obtained step (2) is obtained is well mixed, and is produced.
It is molten rapidly adding water after without caking under the conditions of the effervescence granular that is prepared using said ratio and method is long time stored
Solution, and dissolving is complete, and noresidue can cover the bad smell of Chinese medicine, with good palatability, with significant tonifying liver
Kidney, black beard and hair, antitoxic heart-soothing and sedative, promote the production of body fluid to quench thirst, tranquilize the mind and promote the intelligence function.
Embodiment 3
A kind of sealwort Semen sesami nigrum effervescence granular, it is prepared from by the raw material and auxiliary material of following parts by weight：
Raw material：50 parts of sealwort, 30 parts of Semen sesami nigrum, 20 parts of mulberry fruit, 30 parts of matrimony vine, 10 parts of jujube kernel, 10 parts of radish seed, the bark of official magnolia
6.5 parts, 14 parts of the fruit of glossy privet；
Auxiliary material：48 parts of citric acid, 46 parts of saleratus, 180 parts of maltodextrin, 23 parts of Macrogol 4000, glycyrrhizin
0.75 part, 6 parts of fructose.Preparation method be the same as Example 2.
It is molten rapidly adding water after without caking under the conditions of the effervescence granular that is prepared using said ratio and method is long time stored
Solution, and dissolving is complete, and noresidue can cover the bad smell of Chinese medicine, with good palatability, with significant tonifying liver
Kidney, black beard and hair, antitoxic heart-soothing and sedative, promote the production of body fluid to quench thirst, tranquilize the mind and promote the intelligence function.
Comparative example 1
A kind of sealwort Semen sesami nigrum effervescence granular, it is prepared from by the raw material and auxiliary material of following parts by weight：
Raw material：50 parts of sealwort, 30 parts of Semen sesami nigrum, 20 parts of mulberry fruit, 30 parts of matrimony vine, 10 parts of jujube kernel, 10 parts of radish seed, the bark of official magnolia
6.5 parts, 14 parts of the fruit of glossy privet；
Auxiliary material：47.5 parts of tartaric acid, 47.5 parts of saleratus, 175 parts of maltodextrin, 23 parts of Macrogol 4000, radix glycyrrhizae
0.75 part of glucin, 6 parts of fructose.
Preparation method be the same as Example 2.Citric acid compared with Example 2, is changed to tartaric acid by this example, using said ratio and
Method prepare effervescence granular have significant filling liver kidney, black beard and hair, antitoxic heart-soothing and sedative, promote the production of body fluid to quench thirst, tranquilize the mind and promote the intelligence function, still
There is caking under the conditions of long time stored, dissolution velocity is slow, and dissolving is incomplete, there is residual.
Comparative example 2
A kind of sealwort Semen sesami nigrum effervescence granular, it is prepared from by the raw material and auxiliary material of following parts by weight：
Raw material：50 parts of sealwort, 30 parts of Semen sesami nigrum, 20 parts of mulberry fruit, 30 parts of matrimony vine, 10 parts of jujube kernel, 10 parts of radish seed, the bark of official magnolia
6.5 parts, 14 parts of the fruit of glossy privet；
Auxiliary material：47.5 parts of citric acid, 47.5 parts of sodium acid carbonate, 175 parts of maltodextrin, 23 parts of Macrogol 4000, radix glycyrrhizae
0.75 part of glucin, 6 parts of fructose.
Preparation method be the same as Example 2.Saleratus compared with Example 2, is changed to sodium acid carbonate by this example, is matched somebody with somebody using above-mentioned
Without caking under the conditions of effervescence granular than preparing with method is long time stored, rapid dissolving after adding water, and also dissolving is complete, nothing
Residual, can cover the bad smell of Chinese medicine, with good palatability, with significant filling liver kidney, black beard and hair, promote the production of body fluid only
Yearningly, function, but the effect of antitoxic heart-soothing and sedative, tranquilize the mind and promote the intelligence is poor.
Comparative example 3
A kind of sealwort Semen sesami nigrum effervescence granular, it is prepared from by the raw material and auxiliary material of following parts by weight：
Raw material：50 parts of sealwort, 30 parts of Semen sesami nigrum, 20 parts of mulberry fruit, 30 parts of matrimony vine, 10 parts of jujube kernel, 10 parts of radish seed, the bark of official magnolia
6.5 parts, 14 parts of the fruit of glossy privet；
Auxiliary material：47.5 parts of citric acid, 47.5 parts of saleratus, 175 parts of mannitol, 23 parts of Macrogol 4000, glycyrrhizin
Plain 0.75 part, 6 parts of fructose.
Preparation method be the same as Example 2.Maltodextrin compared with Example 2, is changed to mannitol by this example, using said ratio
The effervescence granular prepared with method has good palatability, with significant filling liver kidney, black beard and hair, antitoxic heart-soothing and sedative, promotes the production of body fluid only
Yearningly, tranquilize the mind and promote the intelligence function, it is long time stored under the conditions of without caking, and dissolving is complete, noresidue, but dissolved adding water after compared with
Slowly.
Comparative example 4
A kind of sealwort Semen sesami nigrum effervescence granular, it is prepared from by the raw material and auxiliary material of following parts by weight：
Raw material：50 parts of sealwort, 30 parts of Semen sesami nigrum, 20 parts of mulberry fruit, 30 parts of matrimony vine, 10 parts of jujube kernel, 10 parts of radish seed, the bark of official magnolia
6.5 parts, 14 parts of the fruit of glossy privet；
Auxiliary material：47.5 parts of citric acid, 47.5 parts of saleratus, 175 parts of maltodextrin, PVP23 parts, glycyrrhizin 0.75
Part, 6 parts of fructose.
Preparation method be the same as Example 2.Macrogol 4000 compared with Example 2, is changed to PVP by this example, is matched somebody with somebody using above-mentioned
Than there is good palatability with effervescence granular prepared by method, with significant filling liver kidney, black beard and hair, antitoxic heart-soothing and sedative, promote the production of body fluid
Quench the thirst, tranquilize the mind and promote the intelligence function, but it is long time stored under the conditions of have a caking, dissolution velocity is slow, and dissolving is incomplete, there is residual
Stay.
Dissolve comparative test：
The effervescence granular (No. 1 group) that is obtained respectively to the proportioning according to embodiment 2, obtained according to the proportioning of comparative example 1
Yam, kudzuvine root effervescence granular (No. 2 groups), obtained according to the proportioning of comparative example 2 yam, kudzuvine root effervescence granular (No. 3 groups),
Yam, kudzuvine root effervescence granular (No. 4 groups) that proportioning according to comparative example 3 is obtained, the mountain obtained according to the proportioning of comparative example 4
The water that medicine root of kudzu vine effervescence granular (No. 5 groups) adds equivalent is dissolved, and caking is whether there is and molten before four groups of effervescence granular dissolvings of observation
Whether particle has residual after solution, and records the dissolving time limit.
Result of the test such as table 1：
Table 1
The composition of raw materials for the sealwort Semen sesami nigrum effervescence granular that 4-18 of the embodiment of the present invention is provided is shown in Table 2-3, and accessory formula is shown in
Table 4-5, other be the same as Examples 2.
Table 2
| Raw material | Embodiment 4 | Embodiment 5 | Embodiment 6 | Embodiment 7 | Embodiment 8 | Embodiment 9 | Embodiment 10 | Embodiment 11 |
| Sealwort | 50 | 55 | 40 | 60 | 45 | 40 | 50 | 45 |
| Semen sesami nigrum | 30 | 20 | 35 | 25 | 40 | 30 | 20 | 35 |
| Mulberries | 18 | 21 | 19 | 22 | 20 | 18 | 21 | 19 |
| Matrimony vine | 35 | 27 | 33 | 25 | 31 | 27 | 25 | 29 |
| Jujube kernel | 10 | 8 | 11 | 9 | 12 | 10 | 8 | 11 |
| Radish seed | 9 | 8 | 10 | 9 | 8 | 11 | 9 | 12 |
| The bark of official magnolia | 7 | 5 | 8 | 5 | 7 | 6 | 8 | 7 |
| The fruit of glossy privet | 12 | 15 | 13 | 16 | 14 | 12 | 15 | 13 |
Table 3
| Raw material | Embodiment 12 | Embodiment 13 | Embodiment 14 | Embodiment 15 | Embodiment 16 | Embodiment 17 | Embodiment 18 |
| Sealwort | 55 | 50 | 60 | 55 | 40 | 60 | 45 |
| Semen sesami nigrum | 25 | 40 | 30 | 20 | 35 | 25 | 40 |
| Mulberries | 22 | 20 | 18 | 21 | 19 | 22 | 20 |
| Matrimony vine | 30 | 31 | 29 | 33 | 27 | 35 | 30 |
| Jujube kernel | 9 | 12 | 10 | 8 | 11 | 9 | 12 |
| Radish seed | 10 | 12 | 11 | 10 | 12 | 11 | 8 |
| The bark of official magnolia | 6 | 8 | 6 | 5 | 7 | 6 | 8 |
| The fruit of glossy privet | 16 | 14 | 12 | 15 | 13 | 16 | 14 |
Table 4
| Raw material | Embodiment 4 | Embodiment 5 | Embodiment 6 | Embodiment 7 | Embodiment 8 | Embodiment 9 | Embodiment 10 | Embodiment 11 |
| Citric acid | 47 | 49 | 45 | 48 | 46 | 49 | 47 | 50 |
| Saleratus | 48 | 45 | 49 | 46 | 50 | 47 | 45 | 48 |
| Maltodextrin | 200 | 150 | 180 | 160 | 190 | 150 | 170 | 160 |
| Macrogol 4000 | 23 | 24 | 20 | 24 | 21 | 25 | 22 | 26 |
| Glycyrrhizin | 0.6 | 0.9 | 0.5 | 0.7 | 0.6 | 0.8 | 0.7 | 0.9 |
| Fructose | 5.5 | 5 | 6 | 5.5 | 6.5 | 5 | 7 | 5.5 |
Table 5
| Raw material | Embodiment 12 | Embodiment 13 | Embodiment 14 | Embodiment 15 | Embodiment 16 | Embodiment 17 | Embodiment 18 |
| Citric acid | 48 | 16 | 49 | 17 | 50 | 46 | 18 |
| Saleratus | 46 | 49 | 47 | 50 | 46 | 48 | 47 |
| Maltodextrin | 180 | 170 | 190 | 180 | 200 | 190 | 170 |
| Macrogol 4000 | 23 | 22 | 24 | 21 | 25 | 20 | 26 |
| Glycyrrhizin | 0.8 | 1 | 0.9 | 0.7 | 1 | 0.5 | 0.8 |
| Fructose | 6.5 | 6 | 7 | 6.5 | 6 | 7 | 5 |
Nutritional test
The present invention using tcm diagnosis be the weak patient of liver kidney deficiency as research object, selection tcm diagnosis is the weak mark of liver kidney deficiency
Standard is that dizziness, fatigue, poliosis, xerophtalmia, soreness and weakness of waist and knees, urine frequency are more, and tongue fur is light white, and arteries and veins is thin and delicate, outside mainly to show
Absent minded, operating efficiency is low, memory loss.Man, each 10 people of female in the object of observation is made a definite diagnosis, without other serious diseases
Disease, the age is 25-45 Sui, average age 38 years old, gives above crowd the edible product 100g for doing inventive embodiments 2 daily, holds
The judgement of curative effect is carried out after continuous 20 days.
Effective standard is：Pulse condition strengthens, and hair blackening can concentrate one's energy, antitoxic heart-soothing and sedative, and urine frequency to be changed
It is kind.
Effectively standard is：Pulse condition is stronger, some blackening of hair, and spirit can substantially be concentrated, and sense of fatigue weakens.
Invalid standard is：Cardinal symptom compares without improvement or aggravated；Wherein, it is whole to diagnose and the judgement of curative effect is gone out
From same doctor, while obtaining the feedback of patient by the way of survey, curative effect is finally determined by both combinations.
It is effective in this experiment to have 12 people, obvious effective rate 60%, effective 8 people, effective percentage 40%, invalid 0 people, inefficiency 0%.
Above test result indicates that the sealwort Semen sesami nigrum effervescence granular that the present invention is provided has well for filling liver kidney, pitch-black hair
Health-care effect, the daily beverage of people can be used as.
The case for drinking the sealwort Semen sesami nigrum effervescence granular that the present invention is provided below in conjunction with part is further detailed：
1. Mr. Zeng, a semiconducter engineering teacher, long-term overtime work is tired, causes that liver kidney deficiency is weak, and hair bleaches, fatigue, small
Just frequently, the sealwort Semen sesami nigrum effervescence granular 100g provided in the embodiment of the present invention 2 is provided in daily food and drink, 20 are persistently drunk
My god, health is significantly improved, hair blackening, and sense of fatigue disappears, and urine frequency to be significantly improved, and spirit also can
Enough high concentrations.
2. Mrs Wang, is engaged in translation, often goes on business, and operating pressure is big, and liver kidney deficiency is weak, sleep insufficiency, irregular menstruation, waist and knee
It is aching and limp, it is listless, the sealwort Semen sesami nigrum solid drink provided in the embodiment of the present invention 2 is provided daily in diet and leisure
Expect 100g, persistently drink 20 days, sleep is substantially improved, menstruation rule, spirit and QI cleaning.
Claims (4)
1. a kind of sealwort Semen sesami nigrum effervescence granular, it is characterised in that be prepared from by the raw material and auxiliary material of following parts by weight：
Raw material：40-60 parts of sealwort, 20-40 parts of Semen sesami nigrum, 18-22 parts of mulberry fruit, 25-35 parts of matrimony vine, 8-12 parts of jujube kernel, radish seed
8-12 parts, 5-8 parts of the bark of official magnolia, 12-16 parts of the fruit of glossy privet；
Auxiliary material：45-50 parts of citric acid, 45-50 parts of saleratus, 150-200 parts of maltodextrin, Macrogol 4000 20-26
Part, 0.5-1 parts of glycyrrhizin, 5-7 parts of fructose.
2. sealwort Semen sesami nigrum effervescence granular as claimed in claim 1, it is characterised in that prepared by the raw material of following parts by weight and
Into：
Raw material：50 parts of sealwort, 30 parts of Semen sesami nigrum, 20 parts of mulberry fruit, 30 parts of matrimony vine, 10 parts of jujube kernel, 10 parts of radish seed, 6.5 parts of the bark of official magnolia,
14 parts of the fruit of glossy privet；
Auxiliary material：47.5 parts of citric acid, 47.5 parts of saleratus, 175 parts of maltodextrin, 23 parts of Macrogol 4000, glycyrrhizin
0.75 part, 6 parts of fructose.
3. the preparation method of sealwort Semen sesami nigrum effervescence granular as described in claim any one of 1-2, it is characterised in that including following
Step：
（1）It is prepared by raw material extraction stiff paste：Above-mentioned raw materials are taken to add water extraction, filtering takes filtrate to be concentrated into relative density for 1.25-
1.35 medicinal extract, it is standby；
（2）The preparation of acid particles：Take whole citric acids, the 45-55% of whole maltodextrin weight, whole polyethylene glycol, whole
45-55%, the 45-55% of all fructose weight of glycyrrhizin weight；The 45-55% of medicinal extract total amount is added, using water as wetting agent,
Softwood is made, then using wet granulation, is dried under the conditions of 40-60 DEG C to water content and is less than 6%；
（3）The preparation of alkali grain：Take whole saleratus, step（2）Remaining maltodextrin, glycyrrhizin, fructose and leaching
Cream, using water as wetting agent, is made softwood, then using wet granulation, is dried under the conditions of 40-60 DEG C to water content and is less than 6%；
（4）By step（2）Obtained acid particles and step（3）The alkali grain of acquisition is well mixed, and is produced.
4. the preparation method of sealwort Semen sesami nigrum effervescence granular as claimed in claim 3, it is characterised in that step（1）Middle specific steps
To take above-mentioned raw materials plus 8-12 times of quality water to boil extraction 1.5-2h, filtering takes residue to repeat extraction, then filtered, and merges two
Secondary filtrate, is concentrated into the medicinal extract that relative density is 1.25-1.35.
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| CN104547555A (en) * | 2015-02-06 | 2015-04-29 | 广州白云山潘高寿药业股份有限公司 | Traditional Chinese medicinal composition having functions of enriching yin and nourishing kidney as well as preparation method and application of traditional Chinese medicinal composition |
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| CN104547555A (en) * | 2015-02-06 | 2015-04-29 | 广州白云山潘高寿药业股份有限公司 | Traditional Chinese medicinal composition having functions of enriching yin and nourishing kidney as well as preparation method and application of traditional Chinese medicinal composition |
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Application publication date: 20170922 |