CN102188610B - Chinese medicinal composition with effect of improving sleeping and preparation method thereof - Google Patents
Chinese medicinal composition with effect of improving sleeping and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal composition with the effect of improving sleeping and a preparation method thereof. The Chinese medicinal composition comprises the following components in percentage by weight: 1 to 30 percent of glossy ganoderma, 0 to 30 percent of dried longan pulp, 0 to 30 percent of spina date seed, 0 to 30 percent of platycladi seed, 0 to 30 percent of tuber fleeceflower stem, 0 to 30 percent of Siberian solomonseal rhizome, 0 to 30 percent of Chinese date and 0.1 to 40 percent of auxiliary materials. In the Chinese medicinal composition, on the basis of the conventional theory of traditional Chinese medical science, Chinese medicines capable of soothing nerves and improving the sleeping quality effectively are screened and are subjected to scientific compatibility, so that the mutually-synergistic effect of the Chinese medicines are exerted to obtain a formula of the Chinese medicinal composition with the effect of improving the sleeping. In the Chinese medicinal composition, the glossy ganoderma is used for tonifying qi and restoring vital energy and nourishing heart and calming nerves; the spina date seed is sour in taste and red in colors, acts on two channels of heart and liver, is used for tonifying liver yin and nourishing mind, and is used as a monarch medicine; the platycladi seed and the tuber fleeceflower stem are sweet in taste and neutral in nature, and are used for nourishing heart qi, moistening kidney dryness, calming soul and nourishing blood and tranquilizing; the dried longan pulp is used for tonifying yang and qi, tonifying spleen and storach and yin blood; the Siberian solomonseal rhizome is used for tonifying middle-Jiao and qi; and the Chinese date also can be used for tonifying qi and enriching blood. By combining the medicines, qi and blood are full, and the mind can be nourished, so the Chinese medicinal composition has the health-care effect of improving the sleeping.
Description
Technical field
The present invention relates to the field of Chinese medicines, more particularly, relate to a kind of Chinese medicine composition of improving sleep function and preparation method thereof that has.
Background technology
Sleep is the necessary process of people's life, is healthy indispensable part, and people's brain needs sleep, if the people loses and to sleep human nerve is first, the reconstruction of related organization and regenerating just has been difficult to.It is that sleeping as seen is how important to human body in sleep that the people has time of 1/3rd in life.So-called insomnia, be often referred to the patient on the length of one's sleep and or quality do not meet and affect a kind of subjectivity experience of social function on daytime.Insomnia is modal sleep disorder, refers to not having enough sleep that a variety of causes causes, difficulty falling asleep, early awakening, and the normal spiritedness of patient is tired, feel dizzy, have a headache that tinnitus, shortness of breath and palpitation, memory are not concentrated, degradation shows under work efficiency.It is dizzy, dizzy, weak that people's second day of evening insomnia will be felt, people's general performance is also poor, as poor as spirit, movement velocity, to the response speed of things, also can slow down, daytime lassitude, have dizzy spells, absent minded.If the long-time sleeping deficiency, brain can not get enough rests, except headache, dizziness, inappetence, because memory coding also can make a mistake, therefore can cause that memory obviously goes down.Insomnia also can damage people's immunocompetence, causes the problems such as susceptible disease.Insomnia also can obviously reduce people's quality of life, as appearring in face too early, wrinkle, skin pigment deepen, and the presenility that seemed, the life-span also can shorten.The traditional Chinese medical science thinks that " insomnia " claims again " being insomnia ", allly easily wakes up to be difficult to fall asleep or sleep or lies awake all night as main clinical manifestation person, all belongs to this category.Insomnia often because of lack of preservation of spirit be, the closest with the heart, liver, spleen relation, because of heart storing spirit, liver storing soul, the defeated cloth seminal fluid of spleen, be source of generating QI and blood, god, soul must rely sustenance and the nourishing of gas and blood.The capable heart arteries and veins of gas, cloudy blood nourishes heart arteries and veins, and in the QI-blood circulation arteries and veins, gains in depth of comprehension are nourished, it is unable that the deficiency of vital energy is transported blood, and the deficiency of YIN sering is not smooth, and hyperamization does not reach the heart, and the heart is become homeless foster, and can not nourish internal organs, the meridians that make moist a little less than the gas deficiency of YIN, and then affect the operation of nutrient blood, whole induced insomnia forms.
Summary of the invention
The objective of the invention is, on the basis of existing theory of Chinese medical science, to filter out and can effectively calm the nerves, improve the Chinese medicine of sleep quality, carry out the science compatibility, bring into play its mutual synergism, thereby obtain a kind of Chinese medicine composition composition formula that improves sleep function that has.
Another object of the present invention is to provide the preparation method of this Chinese medicine composition.
Chinese medicine composition of the present invention counts by weight percentage and comprises following component:
Ganoderma 1%～30%, Arillus Longan 0%～30%, Semen Ziziphi Spinosae 0%～30%,
Semen Platycladi 0%～30%, Caulis Polygoni Multiflori 0%～30%, Rhizoma Polygonati 0%～30%,
Fructus Jujubae 0%～30%, adjuvant 0.1～40%,
Above-mentioned Chinese medicine composition, described Chinese medicine composition adjuvant comprises Fruit powder 0%～30%, edible essence 0%～30%, sweeting agent 0%～30%, acidic flavoring agent 0%～30%, filler 0%～30%, lubricant 0%～30%, antiseptic 0%～30%, suspending agent 0%～30%, food coloring 0%～30%, diluent 0%～30%%, plasticizer 0%～30%, makes peroral dosage form.
Above-mentioned Chinese medicine composition, described peroral dosage form comprises powder, granule, tablet, hard capsule, soft capsule and oral liquid.
The preparation method of above-mentioned Chinese medicine composition, by each component mixed material feeding, water decocts, and then is condensed into extractum, after drying, gets final product.
The preparation method of above-mentioned Chinese medicine composition, Ganoderma 1%～30%, Arillus Longan 0%～30%, Semen Ziziphi Spinosae 0%～30%, Semen Platycladi 0%～30%, Caulis Polygoni Multiflori 0%～30%, Rhizoma Polygonati 0%～30%, Fructus Jujubae 0%～30% water are decocted, then be condensed into concentrated solution, get final product after drying.
The preparation method of above-mentioned Chinese medicine composition, directly allocated with the extract of each component.
Above-mentioned Chinese medicine composition, described Chinese medicine composition is made various peroral dosage forms together with acceptable adjuvant on bromatology, as powder, granule, tablet, hard capsule, soft capsule and oral liquid.
Above-mentioned Chinese medicine composition, described Chinese medicine composition is made various peroral dosage forms together with acceptable composition on bromatology, as powder, granule, tablet, hard capsule, soft capsule, oral liquid, soft sweet.
The invention has the beneficial effects as follows on the basis of existing theory of Chinese medical science, filter out and can effectively calm the nerves, improve the Chinese medicine of sleep quality, carry out the science compatibility, bring into play its mutual synergism, thereby obtain a kind of Chinese medicine composition composition formula that improves sleep function that has.In this Chinese medicine composition, with Ganoderma QI invigorating tonify deficiency, tranquilizing by nourishing the heart, Semen Ziziphi Spinosae sour in the mouth red complexion enters conscience two warps, the cloudy nourishing the heart to keep a sound mind of tonifying liver, and what reuse is monarch drug; Semen Platycladi, both sweet in the mouth of Caulis Polygoni Multiflori are put down, the gas that nourishes heart, and the profit kidney is dry, and the peace soul is determined soul, nourishing blood to tranquillize the mind; Arillus Longan tonifying YANG QI invigorating, tonifying the spleen and stomach, large nourishing YIN blood; The Rhizoma Polygonati invigorating the spleen and replenishing QI; Fructus Jujubae also can vigorate qi and replenish the blood, and all medicines share, and QI and blood is full, and gains in depth of comprehension are foster to moisten, and has the health-care effect that improves sleep.On the other hand, modern study shows that the Semen Ziziphi Spinosae water decoction truly has the effect of improving sleep, and the effect that other are respectively distinguished the flavor of raw medicinal herbs or are improved sleep or are improved cardiac function, have positive effect for the improvement of sleeping.Therefore, we select medicine scientific and reasonable.
Below in conjunction with accompanying drawing, specific embodiments of the invention are elaborated:
The accompanying drawing explanation
Fig. 1 is the oral liquid preparation technology flow chart of Chinese medicine composition of the present invention;
Fig. 2 is the Preparation Technology of Granules flow chart of Chinese medicine composition of the present invention;
Fig. 3 is the hard capsule preparation technology flow chart of Chinese medicine composition of the present invention;
Fig. 4 is the tablet producing technology flow chart of Chinese medicine composition of the present invention;
Fig. 5 is the powder preparation technology flow chart of Chinese medicine composition of the present invention;
Fig. 6 is the soft capsule preparation technology flow chart of Chinese medicine composition of the present invention.
The specific embodiment
Chinese medicine composition of the present invention counts by weight percentage and comprises following component:
Ganoderma 1%～30%, Arillus Longan 0%～30%, Semen Ziziphi Spinosae 0%～30%,
Semen Platycladi 0%～30%, Caulis Polygoni Multiflori 0%～30%, Rhizoma Polygonati 0%～30%,
Fructus Jujubae 0%～30%, adjuvant 0.1～30%.
Described Chinese medicine composition adjuvant comprises Fruit powder 0%～30%, edible essence 0%～30%, sweeting agent 0%～30%, acidic flavoring agent 0%～30%, filler 0%～30%, lubricant 0%～30%, antiseptic 0%～30%, suspending agent 0%～30%, food coloring 0%～30%, diluent 0%～30%%, plasticizer 0%～30%, makes peroral dosage form.
Fruit powder in described adjuvant: one or more in orange powder, Fructus Citri Limoniae powder, cherry powder, apple powder, coconut palm powder form; Edible essence: one or more in orange essence, Fructus Citri Limoniae essence, cherry essence, apple essence, cocoanut flavour form; Sweeting agent: one or more in sucralose, acesulfame potassium, aspartame, mogroside, neotame form; Acidic flavoring agent: one or more in citric acid, malic acid, lactic acid, citric acid form; Filler: one or more in fructose, sugar alcohols, sucrose, starch, dextrin form; Lubricant: one or more in Pulvis Talci, magnesium stearate, silicon dioxide, stearic acid form; Antiseptic: one or more in sodium benzoate, Potassium Benzoate, sorbic acid methyl ester, ethylparaben, P-hydroxybenzoic acid phenyl ester form; Suspending agent: one or more in sodium carboxymethyl cellulose, sodium alginate, Cera Flava form; Food coloring: one or more in burnt sugar coloring, Gardenia Yellow, curcumin, chlorophyll form; Diluent: one or more in vegetable oil, propylene glycol, molecular weight polyethylene glycol 400～2000 form; Plasticizer: by glycerol, sodium carboxymethyl cellulose, sorbitol, oleamide sodium sulfonate, one or more form.
In above-mentioned traditional Chinese medical science compositions, described peroral dosage form comprises powder, granule, tablet, hard capsule, soft capsule and oral liquid.
Embodiment mono-:
The preparation of the oral liquid of Chinese medicine composition of the present invention
Take each component according to following percentage by weight:
Ganoderma 10%, Arillus Longan 10%, Semen Ziziphi Spinosae 10%,
Semen Platycladi 10%, Caulis Polygoni Multiflori 10%, Rhizoma Polygonati 10%,
Fructus Jujubae 15%, apple powder 24.6%, citric acid 0.3%,
Sodium benzoate 0.05%, mogroside 0.03% apple essence 0.02%, add appropriate purified water standardize solution.
Preparation method: by all raw material decoction pieces after the assay was approved, standby, take according to need of production and extracted, concentrate, obtain concentrated solution, add apple essence, mogroside, citric acid, sodium benzoate, purified water mix homogeneously, after instantaneous sterilizing, upper filling machine fill, get final product after sterilizing.
Embodiment bis-:
The preparation of the granule of Chinese medicine composition of the present invention
Take each component according to following percentage by weight:
Ganoderma 5%, Arillus Longan 5% Semen Ziziphi Spinosae 5%,
Semen Platycladi 5%, Caulis Polygoni Multiflori 5% Rhizoma Polygonati 5%,
Fructus Jujubae 15%, apple powder 15%, erythritol 19.98%,
Dextrin 20%, aspartame 0.02%,
Preparation method: by all raw material decoction pieces after the assay was approved, standby, take according to need of production and extracted, concentrate, obtain concentrated solution, add granulator on dextrin, erythritol, apple powder, aspartame mix homogeneously to granulate, after granulate, get final product.
Embodiment tri-:
The preparation of the hard capsule of Chinese medicine composition of the present invention
Take each component according to following percentage by weight:
Ganoderma 10%, Arillus Longan 10%, Semen Ziziphi Spinosae 10%,
Semen Platycladi 10%, Caulis Polygoni Multiflori 10%, Rhizoma Polygonati 10%,
Fructus Jujubae 5%, dextrin 35%,
Preparation method: by all raw material decoction pieces after the assay was approved, standby, take according to need of production and extracted, concentrate, obtain concentrated solution.Add granulator on the dextrin mix homogeneously to granulate, dry rear granulate, then fill with Autocapsulefillingmachine, after polishing, gets final product.
Inspection body's toxicological test through State Food and Drug Administration approval proves, this product has no side effect, and is nontoxic level product.Prove to there is the health care that improves sleep through the animal function test.
Sample carries out the Toxicological evaluation test according to " health food check and assessment technique standard " (2003 editions) pertinent regulations, and result is as follows:
1, acute toxicity test: the maximum tolerated dose MTD of the acute oral of male and female white mice all is greater than 20000mg/kg.
2, micronucleus test result: feminine gender.
3, sperm malformation test result: feminine gender.
4, Salmonella reversion test result: feminine gender.
5, within 30 days, feed result: the laboratory animal growing state is good, hematological examination, and biochemical analysis, when histological examination result of main dirty body is compared with matched group, all no significant difference.
Function:
Capsule is the yellowish-brown powder, the human body recommended amounts is 3.2g/60kg body weight every day, three dosage groups are established in this zoopery, be equivalent to respectively 5,10,30 times of human body recommended dose, per os gives sample 30 days continuously, and experimental result shows: sample can obviously shorten time for falling asleep after animal injection barbital, extend the length of one's sleep, increases the number of animals of falling asleep after injection pentobarbital sodium sub-threshold dose, Sleep latency after shortening injection barbital sodium, and without obviously directly sleep effect.Capsule has to mice the sleep function of improvement.
Embodiment tetra-:
The preparation of the tablet of Chinese medicine composition of the present invention
Take each component according to following percentage by weight:
Ganoderma 5%, Arillus Longan 5%, Semen Ziziphi Spinosae 10%,
Semen Platycladi 10%, Caulis Polygoni Multiflori 5%, Rhizoma Polygonati 10%,
Fructus Jujubae 5%, dextrin 25%, hydroxyl isomaltulose 24.9%,
Cherry essence 0.01%, mogroside 0.02%, silicon dioxide 0.04%, magnesium stearate 0.03%,
Preparation method: by all raw material decoction pieces after the assay was approved, standby, take according to need of production and extracted, concentrate, obtain concentrated solution.Add granulator on appropriate dextrin, hydroxyl isomaltulose, mogroside mix homogeneously to granulate, granulate, then add tablet machine tabletting on cherry essence, silicon dioxide, magnesium stearate to get final product.
Embodiment five:
The preparation of the powder of Chinese medicine composition of the present invention
Ganoderma 5%, Arillus Longan 5%, Semen Ziziphi Spinosae 10%,
Semen Platycladi 10%, Caulis Polygoni Multiflori 5%, Rhizoma Polygonati 10%,
Fructus Jujubae 5%, dextrin 15%, cherry powder 5%,
Erythritol 24.8%, fructose 5%, Fructus Citri Limoniae essence 0.2%,
Preparation method: by all raw material decoction pieces after the assay was approved, standby, take according to need of production and extracted, concentrate, obtain concentrated solution.After adding appropriate dextrin drying, then get final product after adding Fructus Citri Limoniae essence, fructose, cherry powder, erythritol always to mix.
Embodiment six:
The preparation of the soft capsule of Chinese medicine composition of the present invention
Feed liquid: Ganoderma 10%, Arillus Longan 10%, Semen Ziziphi Spinosae 10%,
Semen Platycladi 5%, Caulis Polygoni Multiflori 10%, Rhizoma Polygonati 10%,
Fructus Jujubae 10%, dextrin 15%, soybean oil 19.5%,
Cera Flava 0.5%,
Glue: gelatin 45%, glycerol 15%, purified water 39%,
Burnt sugar coloring 0.8%, ethylparaben 0.2%
Preparation method: by all raw material decoction pieces after the assay was approved, standby, take according to need of production and extracted, concentrate, obtain concentrated solution.After adding appropriate dextrin drying, obtain extract powder.Make suspended matter after mixing according to components by weight percent extract powder, soybean oil, Cera Flava, after mixing with gelatin, glycerol, purified water, burnt sugar coloring, ethylparaben, make rubber, the fill of content suspended matter is pressed into to soft capsule, after washing ball, drying and get final product.
Claims (10)
1. one kind has the Chinese medicine composition that improves sleep function, counts by weight percentage and takes following each component:
Ganoderma 5%～10%, Arillus Longan 5%～10%, Semen Ziziphi Spinosae 5%～10%,
Semen Platycladi 5%～10%, Caulis Polygoni Multiflori 5%～10%, Rhizoma Polygonati 5%～10%,
Fructus Jujubae 5%～15%, adjuvant 0.1～40%.
2. Chinese medicine composition according to claim 1, it is characterized in that: described Chinese medicine composition adjuvant comprises Fruit powder 0%～30%, edible essence 0%～30%, sweeting agent 0%～30%, acidic flavoring agent 0%～30%, filler 0%～30%, lubricant 0%～30%, antiseptic 0%～30%, suspending agent 0%～30%, food coloring 0%～30%, diluent 0%～30%, plasticizer 0%～30%, makes peroral dosage form;
The weight percentage of above-mentioned each Chinese medicine composition adjuvant is zero when different.
3. Chinese medicine composition according to claim 2, it is characterized in that: described peroral dosage form comprises powder, granule, tablet, hard capsule, soft capsule and oral liquid.
4. the preparation method of a Chinese medicine composition as claimed in claim 1 is characterized in that: by each component mixed material feeding, water decocts, and then is condensed into extractum, after drying, gets final product.
5. the preparation method of a Chinese medicine composition claimed in claim 1, it is characterized in that: Ganoderma 5%～10%, Arillus Longan 5%～10%, Semen Ziziphi Spinosae 5%～10%, Semen Platycladi 5%～10%, Caulis Polygoni Multiflori 5%～10%, Rhizoma Polygonati 5%～10%, Fructus Jujubae 5%～15%, adjuvant 0.1～40% water are decocted, then be condensed into concentrated solution, get final product after drying.
6. the preparation method of Chinese medicine composition according to claim 5, is characterized in that: directly with the extract of each component, allocated.
7. Chinese medicine composition according to claim 1, it is characterized in that: described Chinese medicine composition is made various peroral dosage forms together with acceptable adjuvant on bromatology.
8. Chinese medicine composition according to claim 7, it is characterized in that: described peroral dosage form is powder, granule, tablet, hard capsule, soft capsule or oral liquid.
9. Chinese medicine composition according to claim 1, it is characterized in that: described Chinese medicine composition is made various peroral dosage forms together with acceptable composition on bromatology.
10. Chinese medicine composition according to claim 9, it is characterized in that: described peroral dosage form is powder, granule, tablet, hard capsule, soft capsule, oral liquid or soft sweet.
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103083543B (en) * | 2011-11-08 | 2014-07-23 | 陕西方舟制药有限公司 | Chinese medicinal composition for soothing nerves and nourishing brain and preparation method thereof |
| CN102512527B (en) * | 2011-12-26 | 2013-04-24 | 吕怀霞 | Traditional Chinese medicine composition for treating post-stroke depression |
| CN104055871A (en) * | 2014-07-10 | 2014-09-24 | 海南医学院 | Traditional Chinese medicinal composition for improving sleeping quality and application of traditional Chinese medicinal composition |
| CN109363180A (en) * | 2018-12-12 | 2019-02-22 | 江西美咖贸易有限公司 | A kind of health-preserving food and preparation method thereof convenient for improving the elderly's sleep |
| CN112649536A (en) * | 2020-12-31 | 2021-04-13 | 北京康立生医药技术开发有限公司 | Method for detecting functional components of composition |
| CN114009773A (en) * | 2021-10-14 | 2022-02-08 | 宁夏医科大学 | Composition with sleep improving effect and preparation method and application thereof |
| CN115212271B (en) * | 2022-08-11 | 2023-08-11 | 北京了未元中医药研究有限公司 | Traditional Chinese medicine composition for preventing or treating insomnia and preparation method and application thereof |
| CN115192668B (en) * | 2022-09-15 | 2022-12-13 | 江中药业股份有限公司 | Lucid ganoderma compound extract and preparation method and application thereof |
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| CN101518575A (en) * | 2008-02-27 | 2009-09-02 | 北京绿源求证科技发展有限责任公司 | Traditional Chinese medicine for treating diabetic insomnia |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101518575A (en) * | 2008-02-27 | 2009-09-02 | 北京绿源求证科技发展有限责任公司 | Traditional Chinese medicine for treating diabetic insomnia |
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Effective date of registration: 20170123 Address after: 528402 Dongming Road, Guangdong city of Zhongshan province (Shiqi District Private Science and Technology Park) Patentee after: Perfect (China) Co., Ltd. Patentee after: Perfect (Guangdong) Commodity Co., Ltd. Address before: 528402 Dongming Road, Guangdong city of Zhongshan province (Shiqi District Private Science and Technology Park) Patentee before: Perfect (China) Co., Ltd. |