CN107049869A - A kind of children special-purpose mosquito-repellent water - Google Patents
A kind of children special-purpose mosquito-repellent water Download PDFInfo
- Publication number
- CN107049869A CN107049869A CN201710336307.2A CN201710336307A CN107049869A CN 107049869 A CN107049869 A CN 107049869A CN 201710336307 A CN201710336307 A CN 201710336307A CN 107049869 A CN107049869 A CN 107049869A
- Authority
- CN
- China
- Prior art keywords
- mosquito
- repellent water
- children special
- water
- mung bean
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention mainly relates to natural drug biosynthesis technology field, a kind of children special-purpose mosquito-repellent water is disclosed, is made up of following raw material：Pelargonium roseum, ivy glorybind, speedwell, touch perfume, honeybee face cream, mung bean, aloe, sea-buckthorn, olive oil, algal polysaccharides；Fragrant strong, safety non-toxic, without toxic chemicals and alcohol, can keep preventing 100% bite by mosquitos in 5 ~ 6 hours, hence it is evident that improve repelling effect；Mosquito-repellent water abundant raw material, is that pure Chinese medicine is extracted, safety non-toxic is not stimulated, and fragrance comes from traditional Chinese medicine ingredients in itself, without any essence and preservative, green and healthy；Pelargonium roseum, ivy glorybind, speedwell, touch fragrant and honeybee face cream aromatic flavour, rich in multiple fragrance composition, avoid using essence, the sense organ of mosquito can be upset, make mosquito away from human body, it is to avoid bite by mosquitos, acetum is added after crushing, the material composition that acid is dissolved in raw material can be removed, it is to avoid the injury to skin.
Description
Technical field
The invention mainly relates to natural drug biosynthesis technology field, more particularly to a kind of children special-purpose mosquito-repellent water.
Background technology
Mosquito-repellent water, be used for mosquito expelling, it is to avoid the liquid of bite by mosquitos, main component be mosquito repellent amine and alcohol, easily
Cause allergy, and children bear a pretty, delicate skin, and be easier to cause allergy during using mosquito-repellent water, dermatitis can be caused when serious, keeping away
New injury can be brought while exempting from bite by mosquitos again, accordingly, it would be desirable to a kind of children special-purpose mosquito-repellent water.
The content of the invention
In order to make up the defect of prior art, it is an object of the invention to provide a kind of children special-purpose mosquito-repellent water.
A kind of children special-purpose mosquito-repellent water, is made up of the raw material of following parts by weight：Pelargonium roseum 21 ~ 23, ivy glorybind 17 ~
19th, speedwell 17 ~ 19, touch perfume 14 ~ 16, honeybee face cream 14 ~ 16, mung bean 11 ~ 13, aloe 11 ~ 13, sea-buckthorn 11 ~ 13, olive oil 5 ~
7th, algal polysaccharides 0.6 ~ 0.8.
Described mung bean, for the fresh mung bean that ought be produced per year, the weight ratio of mung bean grain and GREEN PEAS is 8 ~ 10:1.
A kind of preparation method of children special-purpose mosquito-repellent water, comprises the following steps：
（1）By Pelargonium roseum, ivy glorybind, speedwell, touch fragrant and honeybee face cream and clean, aromatic flavour, rich in multiple fragrance into
Point, it is to avoid essence is used, the sense organ of mosquito can be upset, makes mosquito away from human body, it is to avoid bite by mosquitos, freeze-drying is extremely
Water content is 3 ~ 5%, is crushed, and the volume fraction for adding 8 ~ 10 times of amounts of Pelargonium roseum weight is 2.3 ~ 2.5% acetum, in
4 ~ 6 DEG C are soaked 6 ~ 7 hours, can remove the material composition that acid is dissolved in raw material, it is to avoid the injury to skin, and filtrate is abandoned in filtering,
Filter residue is cleaned, a filter residue is obtained；
（2）Mung bean is cleaned, the water of 2000 ~ 2500 times of amounts of mung bean weight is added, heating infusion to volume is original 1/10, cold
But to 40 ~ 45 DEG C, sweet mung bean soup is obtained；
（3）Aloe and sea-buckthorn are cleaned, crushed, aloe sea-buckthorn slurry is obtained；
（4）Filter residue and aloe sea-buckthorn slurry are added into sweet mung bean soup, is well mixed, is added complex enzyme, make the quality of complex enzyme dense
Spend for 0.03 ~ 0.05%, in 42 ~ 44 DEG C of stirring enzymolysis 200 ~ 220 minutes, destroy the institutional framework of raw material, improve raw material and utilize
Rate, saves a large amount of production costs, must digest slurry；
（5）Angel wine yeast is accessed into enzymolysis slurry, and addition is the 4 ~ 5% of enzymolysis volume of slurry, is well mixed, it is placed in 32 ~
34 DEG C of ferment at constant temperature 2 ~ 3 days, 17 ~ 19 DEG C are reduced to by temperature, are stood 3 ~ 4 days, are sufficiently destroyed the macromolecular nutritional ingredient of raw material, are produced
The nutrition of raw small molecule and flavor component, tart up, and nourish skin, and the alcohol that fermentation is produced can soak raw material, carry
High effective component extraction rate, obtains fermentation slurry；
（6）Fermentation slurry is filtered, secondary filtrate and secondary filter residue is obtained, secondary filter residue weight 600 ~ 700 is added into secondary filter residue
The water measured again, it is original 1/10 that heating, which is boiled to volume, filters, obtains three filtrates and three filter residues, fermentation residue is added again
The water of 400 ~ 500 times of amounts of weight, it is original 1/10 that heating, which is boiled to volume, and filtering obtains four filtrates and four filter residues, merges
Secondary, three times and four filtrates, rotary evaporation in vacuo obtain extraction concentrate to alcohol-free；
（7）Concentrate will be extracted to filter through 0.22 μm of supermicro filtration membrane, olive oil and algal polysaccharides are added, carry out two sections of homogeneous,
Raw material is sufficiently mixed, in stable condition, not stratified, no precipitation is easy to use, is sterilized 20 ~ 25 minutes through 121 DEG C, be cooled to room
Temperature, obtains children special-purpose mosquito-repellent water；
（8）Packaging, obtains finished product.
The step（1）Freeze-drying, cryogenic temperature be -43 ~ -41 DEG C, dividing plate heating-up temperature be 37 ~ 39 DEG C.
The step（4）Complex enzyme, be made up of the raw material of following parts by weight：Cellulase 14 ~ 16, amylase 12 ~ 14,
Hemicellulase 7 ~ 9, pectase 6 ~ 8.
The step（6）Rotary evaporation in vacuo, temperature is 43 ~ 45 DEG C, rotating speed is 57 ~ 59 revs/min.
The step（7）Two sections of homogeneous, temperature is 67 ~ 69 DEG C, and first paragraph homogenization pressure is 32 ~ 34MPa, and second segment is equal
Matter pressure is 11 ~ 13MPa.
The application method of the children special-purpose mosquito-repellent water, can be applied directly to child skin and clothing without dilution, can add
Enter the hair washing water and water for bathing of children, washed hair and had a bath.
It is an advantage of the invention that：A kind of children special-purpose mosquito-repellent water that the present invention is provided, fragrant strong, safety non-toxic, is free of
Toxic chemicals and alcohol, will not cause the allergic and dermatitis of children, can keep preventing 100% mosquito in 5 ~ 6 hours
Bite, hence it is evident that improve repelling effect；Mosquito-repellent water abundant raw material, is that pure Chinese medicine is extracted, safety non-toxic is not stimulated, and fragrance comes from
Traditional Chinese medicine ingredients in itself, without any essence and preservative, green and healthy；Pelargonium roseum, ivy glorybind, speedwell, touch it is fragrant and
Honeybee face cream aromatic flavour, rich in multiple fragrance composition, it is to avoid use essence, can upset the sense organ of mosquito, make mosquito remote
From human body, it is to avoid bite by mosquitos, acetum is added after crushing, the material composition that acid is dissolved in raw material can be removed, it is to avoid right
The injury of skin；Mung bean, aloe, sea-buckthorn, olive oil and algal polysaccharides, can beauty and skin care, injured skin is carried out quick
Repair, increase skin antiallergic, improve children's skin immunity；Mung bean is added water after infusion, is fully dissolved out effective in mung bean
Composition, adds a filter residue and aloe sea-buckthorn slurry, is digested, destroy the institutional framework of raw material, improve raw material availability
11.6%, save a large amount of production costs；Access Angel wine yeast is added after enzymolysis to be fermented, and is sufficiently destroyed the big of raw material
Molecular nutrition composition, produces nutrition and the flavor component of small molecule, tarts up, and nourishes skin, and the alcohol that fermentation is produced
Raw material can be soaked, and is added water through multiple infusion, effective component extraction rate is improved；Two are carried out after adding olive oil and algal polysaccharides
Duan Junzhi, is sufficiently mixed raw material, in stable condition, not stratified, no precipitation, easy to use.
Embodiment
Illustrate the present invention with specific embodiment below.
Embodiment 1
A kind of children special-purpose mosquito-repellent water, is made up of the raw material of following parts by weight：Pelargonium roseum 21, ivy glorybind 17, speedwell 17,
Touch perfume 14, honeybee face cream 14, mung bean 11, aloe 11, sea-buckthorn 11, olive oil 5, algal polysaccharides 0.6.
Described mung bean, for the fresh mung bean that ought be produced per year, the weight ratio of mung bean grain and GREEN PEAS is 8:1.
A kind of preparation method of children special-purpose mosquito-repellent water, comprises the following steps：
（1）By Pelargonium roseum, ivy glorybind, speedwell, touch fragrant and honeybee face cream and clean, aromatic flavour, rich in multiple fragrance into
Point, it is to avoid essence is used, the sense organ of mosquito can be upset, makes mosquito away from human body, it is to avoid bite by mosquitos, freeze-drying is extremely
Water content is 3 ~ 5%, is crushed, and the volume fraction for adding 8 times of amounts of Pelargonium roseum weight is 2.3% acetum, in 4 DEG C of immersions
6 hours, the material composition that acid is dissolved in raw material can be removed, it is to avoid the injury to skin, filtering abandons filtrate, filter residue is cleaned,
Obtain a filter residue；
（2）Mung bean is cleaned, the water of 2000 times of amounts of mung bean weight is added, heating infusion to volume is original 1/10, is cooled to
40 ~ 45 DEG C, obtain sweet mung bean soup；
（3）Aloe and sea-buckthorn are cleaned, crushed, aloe sea-buckthorn slurry is obtained；
（4）Filter residue and aloe sea-buckthorn slurry are added into sweet mung bean soup, is well mixed, is added complex enzyme, make the quality of complex enzyme dense
Spend for 0.03%, in 42 DEG C of stirring enzymolysis 200 minutes, destroy the institutional framework of raw material, improve raw material availability, save a large amount of raw
Cost is produced, slurry must be digested；
（5）Angel wine yeast is accessed into enzymolysis slurry, addition is the 4% of enzymolysis volume of slurry, is well mixed, is placed in 32 DEG C
Ferment at constant temperature 2 days, 17 DEG C are reduced to by temperature, stand 4 days, are sufficiently destroyed the macromolecular nutritional ingredient of raw material, produce small molecule
Nutrition and flavor component, tart up, and nourish skin, and the alcohol that fermentation is produced can soak raw material, improve active ingredient
Recovery rate, obtains fermentation slurry；
（6）Fermentation slurry is filtered, secondary filtrate and secondary filter residue is obtained, secondary 700 times of amounts of filter residue weight are added into secondary filter residue
Water, it is original 1/10 that heating, which is boiled to volume, and filtering obtains three filtrates and three filter residues, and fermentation residue weight is added again
The water of 500 times of amounts, it is original 1/10 that heating, which is boiled to volume, and filtering obtains four filtrates and four filter residues, merge it is secondary, three
Secondary and four filtrates, rotary evaporation in vacuo obtains extraction concentrate to alcohol-free；
（7）Concentrate will be extracted to filter through 0.22 μm of supermicro filtration membrane, olive oil and algal polysaccharides are added, carry out two sections of homogeneous,
Raw material is sufficiently mixed, in stable condition, not stratified, no precipitation is easy to use, is sterilized 25 minutes through 121 DEG C, be cooled to room temperature,
Obtain children special-purpose mosquito-repellent water；
（8）Packaging, obtains finished product.
The step（1）Freeze-drying, cryogenic temperature be -42 DEG C, dividing plate heating-up temperature be 38 DEG C.
The step（4）Complex enzyme, be made up of the raw material of following parts by weight：Cellulase 15, amylase 13, hemicellulose
Plain enzyme 8, pectase 7.
The step（6）Rotary evaporation in vacuo, temperature is 44 DEG C, rotating speed is 58 revs/min.
The step（7）Two sections of homogeneous, temperature be 68 DEG C, first paragraph homogenization pressure be 33MPa, second segment homogenization pressure
For 12MPa.
The application method of the children special-purpose mosquito-repellent water, can be applied directly to child skin and clothing without dilution, can add
Enter the hair washing water and water for bathing of children, washed hair and had a bath.
Embodiment 2
A kind of children special-purpose mosquito-repellent water, is made up of the raw material of following parts by weight：Pelargonium roseum 22, ivy glorybind 18, speedwell 18,
Touch perfume 15, honeybee face cream 15, mung bean 12, aloe 12, sea-buckthorn 12, olive oil 6, algal polysaccharides 0.7.
Described mung bean, for the fresh mung bean that ought be produced per year, the weight ratio of mung bean grain and GREEN PEAS is 9:1.
Preparation and application be the same as Example 1.
Embodiment 3
A kind of children special-purpose mosquito-repellent water, is made up of the raw material of following parts by weight：Pelargonium roseum 23, ivy glorybind 19, speedwell 19,
Touch perfume 16, honeybee face cream 16, mung bean 13, aloe 13, sea-buckthorn 13, olive oil 7, algal polysaccharides 0.8.
Described mung bean, for the fresh mung bean that ought be produced per year, the weight ratio of mung bean grain and GREEN PEAS is 10:1.
Preparation and application be the same as Example 1.
Comparative example 1
Remove Pelargonium roseum and ivy glorybind, remaining preparation and application, be the same as Example 1.
Comparative example 2
Remove speedwell and touch perfume (or spice), remaining preparation and application, be the same as Example 1.
Comparative example 3
Remove honeybee face cream and mung bean, remaining preparation and application, be the same as Example 1.
Comparative example 4
Remove aloe and sea-buckthorn, remaining preparation and application, be the same as Example 1.
Comparative example 5
Remove olive oil and algal polysaccharides, remaining preparation and application, be the same as Example 1.
Comparative example 6
Removal step（4）In complex enzyme, remaining preparation and application, be the same as Example 1.
Comparative example 7
Removal step（5）In Angel wine yeast, remaining preparation and application, be the same as Example 1.
Comparative example 8
Removal step（7）In two sections of homogeneous, remaining preparation and application, be the same as Example 1.
Comparative example 9
Existing Metadelphene mosquito-repellent water.
The repelling effect of embodiment and comparative example mosquito-repellent water compares：
The adult that selection aedes albopictus is not sucked blood for 4-5 days after sprouting wings, male and female half and half, detection is according to " agriculture chemical registration health desinsection
Agent indoor harmacological effect is evaluated " (GB/T17322.10-1998)；Testing conditions：26 ± 1 DEG C of environment temperature, relative humidity 65 ± 5%,
Experimental result：Smear different time after each group mosquito-repellent water and averagely bite frequency (secondary/2 minutes), embodiment and comparative example mosquito-repellent water
Repelling effect be relatively shown in Table 1.
Table 1：The repelling effect of embodiment and comparative example mosquito-repellent water compares
| Project | 2h | 3h | 4h | 5h | 6h | 7h | 8h |
| Embodiment 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 |
| Embodiment 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Embodiment 3 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
| Comparative example 1 | 3 | 3 | 4 | 5 | 6 | 5 | 7 |
| Comparative example 2 | 5 | 6 | 4 | 7 | 6 | 8 | 7 |
| Comparative example 3 | 6 | 5 | 7 | 5 | 6 | 8 | 6 |
| Comparative example 4 | 3 | 1 | 4 | 3 | 5 | 4 | 5 |
| Comparative example 5 | 2 | 3 | 3 | 2 | 4 | 3 | 4 |
| Comparative example 6 | 1 | 3 | 1 | 2 | 4 | 2 | 5 |
| Comparative example 7 | 2 | 1 | 3 | 3 | 4 | 3 | 6 |
| Comparative example 8 | 3 | 2 | 4 | 1 | 4 | 3 | 5 |
| Comparative example 9 | 0 | 0 | 0 | 2 | 1 | 2 | 3 |
| Blank group | 53 | 52 | 50 | 53 | 51 | 52 | 56 |
Show from the result of table 1, the children special-purpose mosquito-repellent water of embodiment, repelling effect is 100% in 6h, in 8h, mosquito repellent is imitated
Fruit is substantially better than comparative example, illustrates that the children special-purpose mosquito-repellent water that the present invention is provided has good repelling effect.
The anti-inflammatory of embodiment and comparative example mosquito-repellent water repairs effect：
By cleaning agent kunming mice 130,13 groups are randomly divided into, every group 10, male and female half and half, embodiment and comparative example are applied respectively
The mosquito-repellent water of the group is smeared, blank control group smeared physiological saline, in 1 hour after coating, dimethylbenzene 0.03ml drops is right in mouse
Auricular concha two sides causes inflammation, after 2 hours, and mouse is dislocated and put to death, circle is removed at the symmetrical place of left and right ear respectively with diameter 6mm card punch
Auricle, assay balance is weighed, and the weight differences of ears is swelling, and the anti-inflammatory of embodiment and comparative example mosquito-repellent water is repaired effect and is shown in Table
2。
Table 2：The anti-inflammatory of embodiment and comparative example mosquito-repellent water repairs effect
| Project | Mouse number/(only) | Auricle swelling degree/(mg) |
| Embodiment 1 | 20 | 11.63 |
| Embodiment 2 | 20 | 11.56 |
| Embodiment 3 | 20 | 11.54 |
| Comparative example 1 | 20 | 14.52 |
| Comparative example 2 | 20 | 14.76 |
| Comparative example 3 | 20 | 14.95 |
| Comparative example 4 | 20 | 15.72 |
| Comparative example 5 | 20 | 15.83 |
| Comparative example 6 | 20 | 12.77 |
| Comparative example 7 | 20 | 12.37 |
| Comparative example 8 | 20 | 12.52 |
| Comparative example 9 | 20 | 17.32 |
| Blank control group | 20 | 18.03 |
From the results shown in Table 2, the children special-purpose mosquito-repellent water of embodiment group is used for after mouse, the auricle swelling degree of small white mouse
It is substantially small compared with comparative example group and blank control group, illustrate that the children special-purpose mosquito-repellent water that the present invention is provided has obvious anti-inflammatory reparation
Effect.
The malicious combability measurements of embodiment and comparative example children special-purpose mosquito-repellent water：
The children special-purpose mosquito-repellent water of appropriate embodiment and comparative example is taken respectively, it is standby.
（1）Rat oral acute toxicity test：
Experimental group：Big white mouse 130, is randomly divided into 13 groups, every group 10, male and female half and half, respectively by embodiment and comparative example
Children special-purpose mosquito-repellent water gives experiment rat by the oral gavage of 1ml/kgbw amounts, is given once per 4h, observes 7d after four times, see
Any poisoning symptom is whether there is to see；Negative control group：Experimental animal 10, male and female half and half do not give children special-purpose mosquito-repellent water, with examination
Group controlled observation simultaneously is tested, 3 are the results are shown in Table；
（2）Mouse inbred strain：
Experimental group：Male mice 140, is randomly divided into 14 groups, every group 10, respectively by embodiment and the children special-purpose of comparative example
Mosquito-repellent water presses 1ml/kgbw amount, the male mice of the continuous 5d difference gavages group；Positive controls：Mouse essence will easily be caused
The mitomycin C of son distortion presses the male mice of the 1ml/kgbw dosage continuous 5d gavages group；Negative control group：It will be difficult to draw
The distilled water of mouse sperm distortion is played by the male mice of the 1ml/kgbw dosage continuous 5d gavages group, 3 are the results are shown in Table；
Table 3：The malicious combability measurements of embodiment and comparative example children special-purpose mosquito-repellent water
| Project | Rat oral acute toxicity test | Micronucleus number/(‰) |
| Embodiment 1 | None is abnormal or dead | 1.72 |
| Embodiment 2 | None is abnormal or dead | 1.74 |
| Embodiment 3 | None is abnormal or dead | 1.72 |
| Comparative example 1 | None is abnormal or dead | 1.74 |
| Comparative example 2 | None is abnormal or dead | 1.73 |
| Comparative example 3 | None is abnormal or dead | 1.74 |
| Comparative example 4 | None is abnormal or dead | 1.72 |
| Comparative example 5 | None is abnormal or dead | 1.74 |
| Comparative example 6 | None is abnormal or dead | 1.72 |
| Comparative example 7 | None is abnormal or dead | 1.73 |
| Comparative example 8 | None is abnormal or dead | 1.72 |
| Comparative example 9 | None is abnormal or dead | 1.73 |
| Positive controls | — | 18.46 |
| Negative control group | None is abnormal or dead | 1.72 |
Note："-" indicate without.
Show from the result of table 3, children special-purpose mosquito-repellent water of the invention, it is right with feminine gender after rat oral acute toxicity test
Identical according to organizing, none is abnormal or dead, shows the children special-purpose mosquito-repellent water safety non-toxic that the present invention is provided, mouse sperm deformity
After experiment, the mouse sperm deformity rate of embodiment is suitable with negative control group, hence it is evident that less than positive controls, shows that the present invention is carried
The children special-purpose mosquito-repellent water of confession will not produce detrimental effect to the reproduction cell of mouse.
Claims (8)
1. a kind of children special-purpose mosquito-repellent water, it is characterised in that be made up of the raw material of following parts by weight：Pelargonium roseum 21 ~ 23, beat
Bowl spend 17 ~ 19, speedwell 17 ~ 19, touch perfume 14 ~ 16, honeybee face cream 14 ~ 16, mung bean 11 ~ 13, aloe 11 ~ 13, sea-buckthorn 11 ~ 13,
Olive oil 5 ~ 7, algal polysaccharides 0.6 ~ 0.8.
2. children special-purpose mosquito-repellent water according to claim 1, it is characterised in that described mung bean, to be new bud green when what is produced per year
The weight ratio of beans, mung bean grain and GREEN PEAS is 8 ~ 10:1.
3. a kind of preparation method of the mosquito-repellent water of children special-purpose according to claim 1, it is characterised in that comprise the following steps：
（1）By Pelargonium roseum, ivy glorybind, speedwell, touch fragrant and honeybee face cream and clean, freeze-drying to water content is 3 ~ 5%,
Crush, the volume fraction for adding 8 ~ 10 times of amounts of Pelargonium roseum weight is 2.3 ~ 2.5% acetum, and 6 ~ 7 are soaked in 4 ~ 6 DEG C
Hour, filtering abandons filtrate, filter residue is cleaned, obtains a filter residue；
（2）Mung bean is cleaned, the water of 2000 ~ 2500 times of amounts of mung bean weight is added, heating infusion to volume is original 1/10, cold
But to 40 ~ 45 DEG C, sweet mung bean soup is obtained；
（3）Aloe and sea-buckthorn are cleaned, crushed, aloe sea-buckthorn slurry is obtained；
（4）Filter residue and aloe sea-buckthorn slurry are added into sweet mung bean soup, is well mixed, is added complex enzyme, make the quality of complex enzyme dense
Spend for 0.03 ~ 0.05%, in 42 ~ 44 DEG C of stirring enzymolysis 200 ~ 220 minutes, slurry must be digested；
（5）Angel wine yeast is accessed into enzymolysis slurry, and addition is the 4 ~ 5% of enzymolysis volume of slurry, is well mixed, it is placed in 32 ~
34 DEG C of ferment at constant temperature 2 ~ 3 days, 17 ~ 19 DEG C are reduced to by temperature, are stood 3 ~ 4 days, are obtained fermentation slurry；
（6）Fermentation slurry is filtered, secondary filtrate and secondary filter residue is obtained, secondary filter residue weight 600 ~ 700 is added into secondary filter residue
The water measured again, it is original 1/10 that heating, which is boiled to volume, filters, obtains three filtrates and three filter residues, fermentation residue is added again
The water of 400 ~ 500 times of amounts of weight, it is original 1/10 that heating, which is boiled to volume, and filtering obtains four filtrates and four filter residues, merges
Secondary, three times and four filtrates, rotary evaporation in vacuo obtain extraction concentrate to alcohol-free；
（7）Concentrate will be extracted to filter through 0.22 μm of supermicro filtration membrane, olive oil and algal polysaccharides are added, carry out two sections of homogeneous,
Sterilized 20 ~ 25 minutes through 121 DEG C, be cooled to room temperature, obtain children special-purpose mosquito-repellent water；
（8）Packaging, obtains finished product.
4. the preparation method of children special-purpose mosquito-repellent water according to claim 3, it is characterised in that the step（1）Freezing
Dry, cryogenic temperature is -43 ~ -41 DEG C, dividing plate heating-up temperature is 37 ~ 39 DEG C.
5. the preparation method of children special-purpose mosquito-repellent water according to claim 3, it is characterised in that the step（4）It is compound
Enzyme, is made up of the raw material of following parts by weight：Cellulase 14 ~ 16, amylase 12 ~ 14, hemicellulase 7 ~ 9, pectase 6 ~ 8.
6. the preparation method of children special-purpose mosquito-repellent water according to claim 3, it is characterised in that the step（6）Vacuum
Rotary evaporation, temperature is 43 ~ 45 DEG C, rotating speed is 57 ~ 59 revs/min.
7. the preparation method of children special-purpose mosquito-repellent water according to claim 3, it is characterised in that the step（7）Two sections
Homogeneous, temperature is 67 ~ 69 DEG C, and first paragraph homogenization pressure is 32 ~ 34MPa, and second segment homogenization pressure is 11 ~ 13MPa.
8. according to the application method of any one of the claim 1 ~ 7 children special-purpose mosquito-repellent water, it is characterised in that can without dilution
Child skin and clothing are applied directly to, the hair washing water and water for bathing of children can be added, washed hair and had a bath.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710336307.2A CN107049869A (en) | 2017-05-13 | 2017-05-13 | A kind of children special-purpose mosquito-repellent water |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710336307.2A CN107049869A (en) | 2017-05-13 | 2017-05-13 | A kind of children special-purpose mosquito-repellent water |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107049869A true CN107049869A (en) | 2017-08-18 |
Family
ID=59597794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710336307.2A Pending CN107049869A (en) | 2017-05-13 | 2017-05-13 | A kind of children special-purpose mosquito-repellent water |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107049869A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107648417A (en) * | 2017-09-19 | 2018-02-02 | 刘炳发 | A kind of external application Chinese medicine for preventing and treating motion sickness |
| CN108403493A (en) * | 2018-03-30 | 2018-08-17 | 深圳市芭格美生物科技有限公司 | A kind of biological enzyme processing and corrosion-resistant mosquito-expelling and antipruritic plant extraction liquid and the preparation method and application thereof |
| CN108553392A (en) * | 2018-07-04 | 2018-09-21 | 钟鹏 | A kind of preparation method of whitening spot-removing moisturizing aloe cold cream |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1722859A1 (en) * | 2003-12-15 | 2006-11-22 | Natura Cosméticos S.A. | A base composition for preparing multi-functional formulations for care and protection of the skin and hair |
| CN104666139A (en) * | 2013-11-27 | 2015-06-03 | 丁阿维 | Composite mosquito-repellent toner and preparation method thereof |
-
2017
- 2017-05-13 CN CN201710336307.2A patent/CN107049869A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1722859A1 (en) * | 2003-12-15 | 2006-11-22 | Natura Cosméticos S.A. | A base composition for preparing multi-functional formulations for care and protection of the skin and hair |
| CN104666139A (en) * | 2013-11-27 | 2015-06-03 | 丁阿维 | Composite mosquito-repellent toner and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 南京中医药大学: "《中药大辞典 上册》", 31 March 2006 * |
| 朱立春等: "《一本书学会家庭养花和阳台种菜》", 31 August 2015, 中国华侨出版社 * |
| 李光武等: "《精油物语》", 31 January 2010, 安徽科学技术出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107648417A (en) * | 2017-09-19 | 2018-02-02 | 刘炳发 | A kind of external application Chinese medicine for preventing and treating motion sickness |
| CN108403493A (en) * | 2018-03-30 | 2018-08-17 | 深圳市芭格美生物科技有限公司 | A kind of biological enzyme processing and corrosion-resistant mosquito-expelling and antipruritic plant extraction liquid and the preparation method and application thereof |
| CN108553392A (en) * | 2018-07-04 | 2018-09-21 | 钟鹏 | A kind of preparation method of whitening spot-removing moisturizing aloe cold cream |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107874049A (en) | A kind of rose enzyme drink of biology extraction and preparation method thereof | |
| CN106721717A (en) | A kind of preparation technology containing highly-water-soluble dietary fiber jujube juice or red date concentrated clear juice | |
| CN108887674A (en) | A kind of preparation method of lycium ruthenicum composite enzyme liquid | |
| CN105533524B (en) | A kind of black garlic pectase and preparation method thereof | |
| CN106282287A (en) | A kind of method extracting Semen Ginkgo biologically active polypeptide | |
| CN107049869A (en) | A kind of children special-purpose mosquito-repellent water | |
| CN105331476A (en) | Low-alcohol grape wine and preparation method thereof | |
| CN103301321B (en) | Thrombolytic active polysaccharide mixture preparation technology | |
| CN107307254A (en) | One kind moistens the lung and relieve the cough tendril-leaved fritillary bulb Chinese herbal health-caring beverage and preparation method thereof | |
| CN106666304A (en) | Noni fruit drink with anti-aging function and preparation method thereof | |
| CN103315359A (en) | Grifola frondosus solid state fermentation functional beverage and its preparation method | |
| CN106962938A (en) | A kind of bitter buckwheat ferment and preparation method thereof | |
| CN107279973A (en) | Honeysuckle ferment and preparation method thereof | |
| CN111869807A (en) | Anti-depression nutritional granules and preparation method thereof | |
| CN110050928A (en) | A kind of honey raisin tree lactacidase fermenting beverage formula and preparation method thereof | |
| CN105400661A (en) | Lotus leaf wine and preparation method thereof | |
| CN112430516B (en) | Fermented raspberry wine and preparation method thereof | |
| KR101681639B1 (en) | A method for preparing an mask-pack sheet added with the fermented extract of at least one herb consisting of Poncirus Fructus, Torilis japonica DC and Plantaginis Semen showing potent skin beauty treatment effect and the mask-pack sheet prepared thereby | |
| CN107119089A (en) | Corn oligosaccharides beverage method and corn oligosaccharides beverage are prepared based on alpha amylase | |
| CN107319222A (en) | A kind of Anshen Bunao gynostemma pentaphylla Chinese herbal health-caring beverage and preparation method thereof | |
| CN113244140A (en) | Composition for regulating skin micro-ecological balance and application and preparation method thereof | |
| CN107509838A (en) | A kind of preparation method of fermented black rice tea | |
| CN110693794A (en) | Preparation method of pine needle hydrolat amino acid facial cleanser | |
| CN107281052A (en) | A kind of beauty and skin care capsule | |
| CN106860781A (en) | A kind of application of Rhizopus oryzae solid state fermentation extract, preparation method and its anticancer function |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170818 |