CN107048360A - Prepare the fermentation composition and preparation method of the plant enzyme with recuperating gastrointestinal tract function of relaxing bowel - Google Patents

Prepare the fermentation composition and preparation method of the plant enzyme with recuperating gastrointestinal tract function of relaxing bowel Download PDF

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CN107048360A
CN107048360A CN201710233948.5A CN201710233948A CN107048360A CN 107048360 A CN107048360 A CN 107048360A CN 201710233948 A CN201710233948 A CN 201710233948A CN 107048360 A CN107048360 A CN 107048360A
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fermentation
fermentation composition
plant
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weight
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姜红成
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482—Cassia, e.g. golden shower tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8967—Lilium, e.g. tiger lily or Easter lily
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The present invention provides a kind of fermentation composition for preparing the plant enzyme with recuperating gastrointestinal tract function of relaxing bowel, is made up of functional oligose, probiotics and Chinese medical extract；Chinese medical extract is extracted by the raw material of following parts by weight and formed：0.3~2 part of fructus cannabis, 0.5~2.6 part of cassia seed, 0.1~1.6 part of radish seed, 0.2~2 part of lily, 0.1~1.2 part of aloe, 0.3~2 part of hawthorn, 0.1~1.4 part of brush-cherry seed and 0.3~2 part of mulberries.The fermentation composition is novel fermentation product, is that the bacterium bag is easy to use for preparing ferment " fermentation bacterium bag ", the industrialized production of suitable all kinds of plant enzymes.

Description

Prepare the fermentation composition of the plant enzyme with recuperating gastrointestinal tract function of relaxing bowel And preparation method
Technical field
The invention belongs to prevent conditioning maintenance product field, more particularly to prepared by one kind to relax bowel work(with recuperating gastrointestinal tract The fermentation composition and preparation method of the plant enzyme of energy.
Background technology
Plant enzyme is by plants such as tens of kinds of different vegetables and fruits, cereal, seaweeds and mushroom classes, through spontaneous fermentation development Into, the nutrition elite in plant is remained, various ferment, oligosaccharides and a variety of vitamins and the mineral matter needed containing human body, again Abundant SOD antioxidase compositions can be produced, internal oxidation resistance, and then strengthen immunity is improved.
Existing traditional handicraft and modern crafts to ferment has all done further improvement, while also occurring in that some addition benefits Health food prepared by the ferment and ferment of raw bacterium.Probiotics fermention fruits and vegetables, can activate the effective efficiency composition in fruits and vegetables, molten Go out active effect material of more elite.Patent CN106174179A is related to a kind of enzyme composition with effect of relaxing bowel, Said composition includes following component：Probiotics 1-15 parts by weight, plant enzyme stoste 10-120 parts by weight and Chinese medical extract 10- 80 parts by weight；The enzyme composition is inoculated with prebiotic to be mixed after the sterilized technique of Chinese medical extract with plant enzyme stoste Flora carries out sealed fermenting and formed；The Chinese medical extract is extracted by the bulk drug of following parts by weight and formed：2-10 parts of sea-buckthorn, thorn 2-10 parts of rose fruit, 1-8 parts of Chinese yam, 2-10 parts of Asian puccoon, 2-8 parts of charred FRUCTUS CRATAEGI, 1-8 parts of tangerine core, 0.5-6 parts of grapefruit flower, silene aprica 0.5-5 parts of 0.5-6 parts, 0.5-6 parts of jujube and dried orange peel.The enzyme composition, which combines probiotics and functional oligose, to be made With, and traditional Chinese medicine ingredients are added, reach the effect of relaxing bowel.
But the preparation of above-mentioned formula is applied to individual and directly taken, and the plant enzyme stoste of fixation can not expire when reusing Sufficient different taste Man's Demands, and its preparation method is coarse, Chinese medicine dreg sense is strong in the ferment effervescent tablet being prepared into, and mouthfeel is not It is good.And on the other hand, existing ferment bucket prepares plant enzyme using fruit, sugar and water as raw material so that plant enzyme is in Front yard can be prepared, easy to operate.But also having many weak points, the time prepared by 1. ferment is still longer, and easily makes Standby failure；2. made from plant enzyme effect it is indefinite, user can not oneself control prepare effect of plant enzyme, effect is not Substantially；3. the low molecular sugar and polysaccharide majority in the plants such as fruit can not be utilized, it is impossible to be converted into the oligosaccharide of given efficacy.Pin To the deficiency, applicant, which puts forth effort research, has shortening ferment preparation time, easy to use and logical with recuperating gastrointestinal tract ease constipation Just the fermentation composition of effect, i.e. ferment bag.
The content of the invention
It is contemplated that at least solving one of technical problem present in prior art.Therefore, one object of the present invention It is to propose a kind of fermentation composition for preparing the plant enzyme with recuperating gastrointestinal tract function of relaxing bowel, the fermentation composition For directly putting type fermented microbial inoculum, probiotics and functional oligose are used in combination, while adding traditional Chinese medicine ingredients, said composition is existed While with good gut flora regulatory function, the conversion of small molecular sugar and polysaccharide to oligosaccharide can be promoted.The fermentation Effect that plant enzyme prepared by composition plays regulating gastointestinal, relaxed bowel.
Technical scheme is as follows：
A kind of fermentation composition for preparing the plant enzyme with recuperating gastrointestinal tract function of relaxing bowel, the fermentation composition For direct putting type plant enzyme fermenting agent, the fermentation composition includes the component of following parts by weight：0.1~5 part of probiotics With 0.01~10 part of Chinese medical extract,
Wherein, the probiotics is the one or more in Bifidobacterium, lactobacillus and streptococcus thermophilus Freeze-dried powder；
The Chinese medical extract is extracted by the raw material of following parts by weight and formed：0.3~2 part of fructus cannabis, 0.5~2.6 part Cassia seed, 0.1~1.6 part of radish seed, 0.2~2 part of lily, 0.1~1.2 part of aloe, 0.3~2 part of hawthorn, 0.1~1.4 part of brush-cherry seed and 0.3~2 part of mulberries；
The preparation method of the fermentation composition at least comprises the steps：
The particulate fine powder that the functional oligose and Chinese medical extract of predetermined weight number are made uniformly mixes sterilization, kills It is well mixed, granulates with probiotic powder after bacterium, the fermentation composition of powdery is made.
Further in scheme, the fermentation composition also includes 3~22 parts of functional oligose.
Probiotics and functional oligose reasonable combination are used, and both have mutual promoting action, can be doubled to enteron aisle The regulatory function of flora, so that the effect based on gut flora plays more preferable strengthen immunity；And in the traditional Chinese medicine ingredients added, With splendid function of relaxing bowel, such as fructus cannabis, cassia seed, aloe, brush-cherry seed, the compatibility between them, further Ground improves effect of the moisturize laxation of the fermentation composition.And powdery is made in fermentation composition, implementation phase formula is produced, just In the later stage direct plunge into use or family oriented use.
Further, functional oligose of the fermentation composition by parts by weight for 5~10 parts, 1~3 part prebiotic Bacterium and 0.5~1 Chinese medical extract composition.
Further, Chinese medical extract is extracted by the raw material of following parts by weight and formed：：0.9~1.4 part of fructus cannabis, 1~ 1.5 parts of cassia seed, 0.4~0.9 part of radish seed, 0.6~1.2 part of lily, 0.3~0.6 part of aloe, 0.9~1.2 part Hawthorn, 0.6~0.9 part of brush-cherry seed and 0.9~1.4 part of mulberries.
In such scheme, the functional oligose is selected from chitosan, xylo-oligosaccharide, kanjak mannan-oligosaccharides, sweet dew Oligosaccharide, milk ketose, raffinose, soyabean oligosaccharides, FOS, galactooligosaccharide, lactosucrose, konjac mannan sugar, One or more in trehalose, palatinose and inulin；
Bifidobacterium includes bifidobacterium longum (B.longum), short Bifidobacterium Bifidum (B.breve) (B.breve), bifidobacterium infantis And the one or more in bifidobacterium lactis (B.ifidobacterium) (B.infantis)；
Lactobacillus includes Lactobacillus rhamnosus (L.rhamnosus), Lactobacillus casei (Lactobacillus Casei), lactobacillus acidophilus (L.acidophilus), Lactobacillus plantarum (Lactobacillus plantarum), the newborn bar of saliva Bacterium (Lactobacillus salivarius), Lactobacillus helveticus (Lactobacillus helveticus), Bu Shi lactobacillus (Lactobacillus buchneri), lactobacillus bulgaricus (Lactobacillus.Bulgaricus), the newborn bar of secondary cheese One kind or several in bacterium (Lactobacillus paracasei) and lactobacillus reuteri (Lactobacillus reuteri) Kind.
The preferred scheme of the fermentation composition of the present invention, in addition to the resistant dextrin that parts by weight are 10~30 parts, resistance Dextrin is that a kind of Low Caloric Polydextrose processed by starch belongs to low molecule water-soluble dietary fiber, common with other components Use, improve the absorptivity of nutrition, at the same beneficial to the shaping of fermentation composition granule, and further promote intestines peristalsis, protect Intestinal health is held, and controls the absorption of grease and sugar.
Further, the functional oligose is soyabean oligosaccharides, and soyabean oligosaccharides can promote Bifidobacterium in enteron aisle Growth, promotes enterocinesia to accelerate excretion and the generation and absorption of Parenteral Nutrition material, and produce defecating feces excretion；
The probiotics is probiotics powder agent, is uniformly mixed by the pulvis of following parts by weight：Bifidobacterium 4.5~ 2.3~3 parts of 6 parts, 1~2.6 part of lactobacillus bulgaricus, 2~2.8 parts of lactobacillus acidophilus and lactobacillus paracasei, the benefit The viable bacteria content of raw bacteria powder is 2 × 106~2 × 1010cfu/g；By all kinds of strains of reasonable disposition and consumption, optimize this patent The strain of products'texture, can effectively shorten fermentation composition in the time for preparing plant enzyme, and it is steady that it can be made to prepare texture Fixed plant enzyme.
The source of above-mentioned all kinds of probiotics powder agents：It is the pulvis of commercially available all kinds of strains or by will be commercially available all kinds of Strain is collected by centrifugation with after washing thalline, drying is prepared into active powder through Liquid Culture.
In the one of preferred scheme of fermentation composition of the present invention, it is 1 that the fermentation composition, which also includes parts by weight, ~3 parts of saccharomycete, 1~3 part of acetobacter and 1~5 part of lactic acid bacteria；
The preparation method of the fermentation composition also includes：
(1) softwood is made in the fermentation composition of the powdery of 1/2 amount, is well mixed with the lactic acid bacteria of the parts by weight Extrusion is carried out afterwards and makes ball, and capsule core is made；
(2) fermentation composition of the powdery of 1/2 amount is mixed with the saccharomycete and acetobacter of the parts by weight It is even, softwood thing is made, it is standby；
(3) obtained capsule core is placed in the coating solution prepared in advance, be coated；
(4) the round as a ball extruding in the softwood thing of step (2) to the coating capsule core after Cotton seeds, then be dried, produce Pellet fermentation composition；
Wherein, the coating solution is by 100-55,0.1-2 parts of Eudragit L that parts by weight are 0.4-10 parts Hydroxypropyl Methylcellulose Phathalate and 0.05-0.2 parts of castor oil add the aqueous dispersion that appropriate purified water is configured to.
The preparation method of fermentation composition of the present invention, comprises the following steps：
(1) preparation of Chinese medical extract：
The fructus cannabis of predetermined weight part, cassia seed, radish seed, lily, aloe, hawthorn, brush-cherry seed are respectively crushed into slightly Powder, the water of various 8 times of weight of coarse powder and mulberries keeps 4h at 80-90 DEG C of temperature, is then cooled to 40 DEG C, plus 2 times of weights The alcohol reflux 4h that concentration is 75% is measured, filtering obtains the first filtrate；The water of 3 times of weight of filter residue is added, at 80-90 DEG C of temperature 2.5h is kept, 30 DEG C is then cooled to, filters to obtain the second filtrate；Merging filtrate, is concentrated under reduced pressure, is freeze-dried, low-temperature grinding into It is ground into 0.05-0.2mm traditional Chinese medicine fine powder；
(2) height that 3000-5000 turns is carried out after the traditional Chinese medicine fine powder in step (1) is mixed with emulsifying agent, water with cutter Speed shearing, is added dropwise wall material monomer and carries out wall building, form nano level Chinese medicine particulate while stirring；
(3) the Chinese medicine particulate in the functional oligose, resistant dextrin and step (2) of predetermined weight number is uniformly mixed Close, sterilized by heat exchanger, condition is 99 DEG C, 300s；
(4) mixture is cooled to 40-45 DEG C after sterilizing, and the probiotics for adding scheduled volume is freeze-dried, is added after being well mixed Dry granulating machine is granulated, and the fermentation composition of powdery is made, and sterile packing is produced.
Fermentation composition viable bacteria rate prepared by the above method is high, the traditional Chinese medicine fine powder delicate mouthfeel of particulate processing, Chinese medicine particulate The capsule heart is slowly discharged, with good slow release effect by processes such as dissolving, infiltration, diffusions through membranous wall.
A further object of the present invention is to provide a kind of plant enzyme with recuperating gastrointestinal tract function of relaxing bowel, is pin Personal or Homemade plant enzyme is formulated, the preparation method of the plant enzyme comprises the following steps：
(a) powdery fermentation composition is prepared
(b) mixed material：1kg plant material is cleaned, is put into the sugar of 0.3~0.6kg weight in ferment bucket, adds 5 ~6L pure water, be well mixed, while add weight be 20~50g the step of (a) prepare fermentation composition to ferment bucket Interior, capping carries out lucifuge fermentation in fermentation temperature is 28~30 DEG C of environment；
(c) ferment：Fermentate in ferment bucket is carried out after stirring sooner or later once daily, 5~8d of fermentation, filtering, i.e., Obtain plant enzyme.
This method simple and fast, realizes the self-control of various functions plant enzyme, and this method preferably uses ferment bucket and made Standby, ferment bucket is from market sale；Also the vessel of closed environment can be used to be prepared.
Another preferred scheme of the preparation method of plant enzyme of the present invention, the described method comprises the following steps：
A) fermentation composition of powdery is prepared
B) preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight adds into plant material Enter 10L pure water, be well mixed, stand after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extraction liquid；
C) preparation of plant enzyme stoste：Composite flora is inoculated with into plant extraction liquid, mixing is placed in closed environment, carried out Lucifuge is fermented 1~2 month, obtains plant enzyme stoste；
Wherein inoculum concentration is 8~12%；Composite flora is saccharomyces cerevisiae, the newborn subspecies of Lactobacillus delbrueckii, Lactobacillus plantarum, leather It is several in Lan Shi lactobacillus, lactobacillus acidophilus and acetobacter；
D) preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L Water and plant material 0.5kg, the plant enzyme stoste for adding 150ml are fermented in closed environment, and fermentation temperature is 28 ~30 DEG C, deflate 1~2 time daily, after 1~2d of fermentation；Fermentation composition prepared by 30g step a) is added, fermentation temperature is not Become, continue the 3-4d that ferments, filtering produces plant enzyme.
Which is applied to industrial production, with reference to the secondary of plant enzyme stoste first fermentation and fermentation composition of the present invention Multistage deep layer liquid state fermentation is realized in fermentation；Greatly improve fermentation efficiency.It can release in fermentation process and be enclosed in Chinese medicine or plant Structure and intracellular nutrients element, retain the original active material of plant, insoluble fibre is changed into solvable in plant Property dietary fiber improve effect of original plant.
The preferred scheme of the preparation method of another plant enzyme, the use of the fermentation composition also constructed for double-deck pellet Method, the preparation method comprises the following steps：
I the fermentation composition of pellet) is prepared
II) the preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of 1kg weight is added into plant material, and 10L pure water is added, is well mixed, is stood after 1~2d of extraction, high-temperature sterilization is carried out, filtering obtains plant extraction liquid；
III) the preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L water and plant extraction liquid 1kg, add 30g step II) prepare pellet fermentation composition, in closed environment carry out Fermentation；Fermentation temperature is 30~32 DEG C, is deflated 1~2 time daily；Ferment after 1~2d, insertion conduit is passed through air, daily ventilation 2-4 times, each 10-30min, and control fermentation temperature to be 35~37 DEG C；Filtered after 5~7d of fermentation, produce plant enzyme.
This method simple and fast, realizes the self-control of various functions plant enzyme, and fermentation process is simply deep, once-through operation Realize second order fermentation, or even multistage fermentation；The plant enzyme rich in nutrition content being prepared into, human absorptivity is high, further carries Its high effect.
The present invention has the following advantages that compared with prior art：
The fermentation composition that the present invention is developed is novel fermentation product, is for preparing ferment " fermentation bacterium bag ", improveing Direct addition probiotics prepares the traditional handicraft of plant enzyme, and the bacterium bag is easy to use, can directly be existed with powdered bacterium bag Sell on the market, can also put into the industrialized production of all kinds of plant enzymes, realize that matching somebody with somebody for plant enzyme is used and diversification Functional configuration, is greatly enhanced the preparation efficiency of plant enzyme.
The traditional Chinese medicinal components added in the fermentation composition of the present invention have its physiologically active and health-care effect, while being prebiotic Bacterium supplements the nutrients in fermentation, with higher practical value, and the traditional Chinese medicine ingredients of the present invention can effective recuperating gastrointestinal tract profit Intestines defaecation；Rationally, curative effect is clear and definite, with Synergistic for compatibility between probiotics, functional oligose and Chinese medicine each component Effect.
The plant enzyme of the present invention meets requirement and the development trend of health products, and plant enzyme can be produced largely to be had to human body The comprehensive plant enzyme of benefit, metabolism and function adjustment of these enzymes to human body plays an important role, while also containing vitamin, mineral The nutritional ingredients such as matter, amino acid, organic acid, oligosaccharide.The present invention is fermented by adding above-mentioned fermentation composition, fermentation group Traditional Chinese medicine ingredients in compound are changed through probiotics, are become small molecule by macromolecular, are easily absorbed by the body；The addition of probiotics can Toxicity can be decomposed by improving in Chinese medicine taste, fermentation process, realization really has no toxic side effect, while prepared by the fermentation composition Plant enzyme improves drug effect, the regulation gut flora of energy highly significant compared to traditional Chinese medicine.The plant enzyme is particularly suitable for Intestine-dryness due to consumption of fluid, stagnation of QI due to dyspepsia, the crowd of abdominal distention constipation and use, taken as daily drinks as the food of routine servicing, Improve lipid-metabolism from the angle effected a permanent cure, improve body immunity etc., realize the purpose of health care.
In addition, the technical process that the direct addition of fermentation composition prepares plant enzyme is simple, it is with low cost, it is easy to accomplish big Large-scale production, compared to prior art, shortens the time for preparing and fermenting, and safe preparation process.
The source of the Chinese medicine material composition of the present invention：
Fructus cannabis：This product is moraceae plants hemp Cannabis sativa L. dry mature fruit.
Cassia seed：This product is legume Cassia Cassia obtusifolia L. or little Cassia tora Cassia tora L. Dry mature seed.
Radish seed：This product is crucifer radish Raphanus sativus L. dry mature seed.
Lily：Product are liliaceous plant tiger lily Lilium lancifolium Thunb., lily Lilium brownii F.E.Brown var.viridulum Baker or Lilium tenuifolium Lilium pumilum DC. dry meat scale leaf.
Aloe：This product is liliaceous plant aloe barbadensis Miller Aloe barbadensis Miller, Aloe ferox Miller Aloeferox Miller or other belong to the dry product of concentrated juice of kindred plant leaf together.
Hawthorn：This product is rosaceous plant large-fruited Chinese hawthorn Crataegus pinnatifida Bge.var.major N.E.Br. or hawthorn Crataegus pinnatifida Bge. dry mature fruit.
Brush-cherry seed：This product is rosaceous plant Europe Lee (sour fourth, Xiao Li are red) Prunus humilis Bunge., strongly fragrant Lee is (red Plum) Prunus japonica Thunb. or Amygdalus pedunculata Prunus pedunculata Maxim. dry mature seed.
Mulberries：This product is moraceae plants mulberry Morus alba L. drying fruit ear.
Embodiment
The fermentation composition of embodiment 1
The prescription of the fermentation composition of the present embodiment is：
Functional oligose：Soyabean oligosaccharides 80g
Probiotics powder agent：24g, wherein containing 4.5 parts of Bifidobacterium, 1 part of lactobacillus bulgaricus, thermophilic in per g probiotic powders 2.3 parts of 2 parts of Lactobacillus lactis and lactobacillus paracasei；
Traditional Chinese medicine ingredients：8g, is formed wherein being extracted per g Chinese medical extracts by the raw material of following portions by weight：Fructus cannabis 0.9 Part, 1 part of cassia seed, 0.4 part of radish seed, 0.6 part of lily, 0.3 part of aloe, 0.9 part of hawthorn, 0.6 part of brush-cherry seed and mulberries 0.9 Part；
Resistant dextrin 80g.
Preparation method：
(1) preparation of Chinese medical extract：
The fructus cannabis of predetermined weight part, cassia seed, radish seed, lily, aloe, hawthorn, brush-cherry seed are respectively crushed into slightly Powder, the water of various 8 times of weight of coarse powder and mulberries keeps 4h at 80-90 DEG C of temperature, is then cooled to 40 DEG C, plus 2 times of weights The alcohol reflux 4h that concentration is 75% is measured, filtering obtains the first filtrate；The water of 3 times of weight of filter residue is added, at 80-90 DEG C of temperature 2.5h is kept, 30 DEG C is then cooled to, filters to obtain the second filtrate；Merging filtrate, is concentrated under reduced pressure, is freeze-dried, low-temperature grinding into It is ground into 0.05-0.2mm traditional Chinese medicine fine powder；
(2) height that 3000-5000 turns is carried out after the traditional Chinese medicine fine powder in step (1) is mixed with emulsifying agent, water with cutter Speed shearing, is added dropwise wall material monomer and carries out wall building, form nano level Chinese medicine particulate while stirring；
(3) the Chinese medicine particulate in the functional oligose, resistant dextrin and step (2) of predetermined weight number is uniformly mixed Close, sterilized by heat exchanger, condition is 99 DEG C, 300s；
(4) mixture is cooled to 40-45 DEG C after sterilizing, and the probiotics for adding scheduled volume is freeze-dried, is added after being well mixed Dry granulating machine is granulated, and the fermentation composition of powdery, sterile pack, every bag of 30g is made.
The fermentation composition of embodiment 2
The prescription of the fermentation composition of the present embodiment is：
Functional oligose：Soyabean oligosaccharides 50g
Probiotics powder agent：10g, wherein containing 6 parts of Bifidobacterium, 2.6 parts of lactobacillus bulgaricus, thermophilic in per g probiotic powders 3 parts of 2.8 parts of Lactobacillus lactis and lactobacillus paracasei；
Traditional Chinese medicine ingredients：5g, is formed wherein being extracted per g Chinese medical extracts by the raw material of following portions by weight：Fructus cannabis 1.4 Part, 1.5 parts of cassia seed, 0.9 part of radish seed, 1.2 parts of lily, 0.6 part of aloe, 1.2 parts of hawthorn, 0.9 part of brush-cherry seed and mulberries 1.4 part.
Preparation method：
(1) preparation of Chinese medical extract：
The fructus cannabis of predetermined weight part, cassia seed, radish seed, lily, aloe, hawthorn, brush-cherry seed are respectively crushed into slightly Powder, the water of various 8 times of weight of coarse powder and mulberries keeps 4h at 80-90 DEG C of temperature, is then cooled to 40 DEG C, plus 2 times of weights The alcohol reflux 4h that concentration is 75% is measured, filtering obtains the first filtrate；The water of 3 times of weight of filter residue is added, at 80-90 DEG C of temperature 2.5h is kept, 30 DEG C is then cooled to, filters to obtain the second filtrate；Merging filtrate, is concentrated under reduced pressure, is freeze-dried, low-temperature grinding into It is ground into 0.05-0.2mm traditional Chinese medicine fine powder；
(2) height that 3000-5000 turns is carried out after the traditional Chinese medicine fine powder in step (1) is mixed with emulsifying agent, water with cutter Speed shearing, is added dropwise wall material monomer and carries out wall building, form nano level Chinese medicine particulate while stirring；
(3) the Chinese medicine particulate in the functional oligose of predetermined weight number and step (2) is uniformly mixed, passes through heat exchange Device is sterilized, and condition is 99 DEG C, 300s；
(4) mixture is cooled to 40-45 DEG C after sterilizing, and the probiotics for adding scheduled volume is freeze-dried, is added after being well mixed Dry granulating machine is granulated, and the fermentation composition of powdery, sterile pack, every bag of 30g is made.
The fermentation composition of embodiment 3
The prescription of the fermentation composition of the present embodiment is：
Functional oligose：Soyabean oligosaccharides 60g
Probiotics powder agent：2g, wherein containing 5.5 parts of Bifidobacterium, 2 parts of lactobacillus bulgaricus, acidophilus in per g probiotic powders 2.6 parts of 2.4 parts of lactobacillus and lactobacillus paracasei；
Traditional Chinese medicine ingredients：0.2g, is formed wherein being extracted per g Chinese medical extracts by the raw material of following portions by weight：Fructus cannabis 0.3 Part, 0.5 part of cassia seed, 0.1 part of radish seed, 0.2 part of lily, 0.1 part of aloe, 0.3 part of hawthorn, 0.1 part of brush-cherry seed and mulberries 0.3 part；
Resistant dextrin 200g
Preparation method：Prepared according to the preparation method of embodiment 1, pulvis, every bag of 30g is made.
The fermentation composition of embodiment 4
The prescription of the fermentation composition of the present embodiment is：
Functional oligose：Chitosan 104g, mannan-oligosaccharides 116g；
Probiotics powder agent：50g, wherein in per g probiotic powders containing 5.5 parts of Bifidobacterium, 2.4 parts of lactobacillus bulgaricus, 2.4 parts of 1.7 parts of lactobacillus acidophilus and Lactobacillus plantarum；
Traditional Chinese medicine ingredients：100g, is formed wherein being extracted per g Chinese medical extracts by the raw material of following portions by weight：Fructus cannabis 2 2 parts of part, 2.6 parts of cassia seed, 1.6 parts of radish seed, 2 parts of lily, 1.2 parts of aloe, 2 parts of hawthorn, 1.4 parts of brush-cherry seed and mulberries.
Preparation method：Prepared according to the preparation method of embodiment 2, pulvis, every bag of 30g is made.
The fermentation composition of embodiment 5
The prescription of the fermentation composition of the present embodiment is：
The oligomeric xylo-oligosaccharide 83g of feature, soy oligosaccharides Icing Sugar 61g, FOS 56g；
Probiotics powder agent：20g, wherein containing 4 parts of bifidobacterium longum, 1.8 parts of Lactobacillus casei, saliva in per g probiotic powders 2.2 parts of 0.9 part of lactobacillus, 1.5 parts of lactobacillus acidophilus and Lactobacillus plantarum；Sugar：
Traditional Chinese medicine ingredients：50g, is formed wherein being extracted per g Chinese medical extracts by the raw material of following portions by weight：Fructus cannabis 1.3 Part, 1 part of cassia seed, 0.5 part of radish seed, 0.7 part of lily, 0.8 part of aloe, 1 part of hawthorn, 0.5 part of brush-cherry seed and mulberries 0.8 Part；
Resistant dextrin 300g.
Preparation method：Prepared according to the preparation method of embodiment 1, pulvis, every bag of 30g is made.
The fermentation composition of embodiment 6
The prescription of the fermentation composition of the present embodiment is：
Functional oligose：Xylo-oligosaccharide 43g, mannan-oligosaccharides 40g, FOS 23g, galactooligosaccharide 22g and Trehalose 19g；
Probiotics powder agent：10.1g, wherein containing 2.3 parts of bifidobacterium breve, 2 parts of bifidobacterium lactis, mouse in per g probiotic powders 2.4 parts of lactobacillus of Lee's sugar, 1.3 parts of Lactobacillus helveticus, 1 part of Bu Shi lactobacillus, 1.7 parts of lactobacillus bulgaricus and secondary cheese breast 0.9 part of bacillus；
Traditional Chinese medicine ingredients：4.55g, is formed wherein being extracted per g Chinese medical extracts by the raw material of following portions by weight：Fructus cannabis 0.6 part, 2 parts of cassia seed, 1.1 parts of radish seed, 1.5 parts of lily, 0.4 part of aloe, 0.8 part of hawthorn, 1.2 parts of brush-cherry seed and mulberries 1.6 part；
Resistant dextrin 70.5g.
Preparation method：Prepared according to the preparation method of embodiment 1, pulvis, every bag of 30g is made.
The fermentation composition of embodiment 7
The prescription of the fermentation composition of the present embodiment is：
The pulvis fermentation composition 32g that embodiment 1 is made；Saccharomycete 1g；Acetobacter 1g；Lactic acid bacteria 1g；Coating solution by Eudragit L 100-5520g, Hydroxypropyl Methylcellulose Phathalate 5g and the appropriate purifying of castor oil 2.5g additions Water is prepared；
Preparation method：
(1) softwood is made in the pulvis fermentation composition of 1/2 amount, after being well mixed with the lactic acid bacteria of the parts by weight Carry out extrusion and make ball, capsule core is made；
(2) the pulvis fermentation composition of 1/2 amount is well mixed with the saccharomycete and acetobacter of the parts by weight, Softwood thing is made, it is standby；
(3) obtained capsule core is placed in the coating solution prepared in advance, be coated；
(4) the round as a ball extruding in the softwood thing of step (2) to the coating capsule core after Cotton seeds, then be dried, produce Pellet fermentation composition, packaging.
Wherein obtained pellet diameters are 4-7mm, a diameter of 2-5mm of capsule core；It is preferred that pellet diameters 5mm, capsule core is a diameter of 2.8mm。
The fermentation composition of embodiment 8
The prescription of the fermentation composition of the present embodiment is：
The pulvis fermentation composition 23.1g that embodiment 3 is made；Saccharomycete 3g；Acetobacter 3g；Lactic acid bacteria 5g；Coating solution It is appropriate pure by Eudragit L 100-5510g, Hydroxypropyl Methylcellulose Phathalate 2g and castor oil 0.2g addition Change water to prepare；
Preparation method：
(2) softwood is made in the pulvis fermentation composition of 1/2 amount, after being well mixed with the lactic acid bacteria of the parts by weight Carry out extrusion and make ball, capsule core is made；
(2) the pulvis fermentation composition of 1/2 amount is well mixed with the saccharomycete and acetobacter of the parts by weight, Softwood thing is made, it is standby；
(3) obtained capsule core is placed in the coating solution prepared in advance, be coated；
(4) the round as a ball extruding in the softwood thing of step (2) to the coating capsule core after Cotton seeds, then be dried, produce Pellet fermentation composition, packaging.
Wherein obtained pellet diameters are 4-7mm, a diameter of 2-5mm of capsule core；It is preferred that pellet diameters 5mm, capsule core is a diameter of 2.8mm。
The plant enzyme of embodiment 9
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition：Prepared according to the fermentation composition of embodiment 1；
B) preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight adds into plant material Enter 10L pure water, be well mixed, stand after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extraction liquid；
C) preparation of plant enzyme stoste：Composite flora is inoculated with into plant extraction liquid, mixing is placed in closed environment, carried out Lucifuge is fermented 2 months, obtains plant enzyme stoste；
Wherein inoculum concentration is 12%；Composite flora is Lactobacillus plantarum, gram lactobacillus, lactobacillus acidophilus and acetic acid In bacillus；
D) preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L Water and plant material 0.5kg, the plant enzyme stoste for adding 150ml are fermented in closed environment, and fermentation temperature is 28 ~30 DEG C, deflate 1~2 time daily, after 1~2d of fermentation；Fermentation composition prepared by 30g step a) is added, fermentation temperature is not Become, continue the 3-4d that ferments, filtering produces plant enzyme.
Wherein, plant material selects apple 500g, soybean 200g and tomato 300g, and clean section is used.
Organoleptic parameters：The plant enzyme uniform color, free from admixture, in bronzing, there is strong fruity and fermentation fragrance, mouth Sense is mellow, and comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
The plant enzyme of embodiment 10
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition：Prepared according to the fermentation composition of embodiment 2；
B) preparation of plant extraction liquid：1kg plant material is cleaned, the sugared to plant material of 0.3~0.6kg weight is added In, and 5~6L pure water is added, it is well mixed, stands after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extract Liquid；
C) mixing and initial fermentation：Add plant of fermentation composition of the weight for 60g step a) preparations into step b) In thing extract solution, mixing is placed in closed environment, keeps 28 DEG C of fermentation temperature, carries out lucifuge fermentation, obtains initial fermentation liquid；
D) zymotic fluid carries out after-ripening 7d in closed environment, filtering, produces plant enzyme.
Wherein, plant material selects Kiwi berry 100g, strawberry 90g, hawthorn 40g, mango 220g, carrot 80g, ternip 140g, Chinese cabbage 150g, agaric 80g and mushroom 100g.
Organoleptic parameters：The plant enzyme uniform color, between buff and brown, having, strong fruity and fermentation are fragrant Gas, mellow in taste, comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
The plant enzyme of embodiment 11
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition：Prepared according to the fermentation composition of embodiment 3；
B) preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight adds into plant material Enter 10L pure water, be well mixed, stand after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extraction liquid；
C) preparation of plant enzyme stoste：Composite flora is inoculated with into plant extraction liquid, mixing is placed in closed environment, carried out Lucifuge is fermented 1 month, obtains plant enzyme stoste；
Wherein inoculum concentration is 8~12%；Composite flora is saccharomyces cerevisiae, the newborn subspecies of Lactobacillus delbrueckii, Lactobacillus plantarum, leather It is several in Lan Shi lactobacillus, lactobacillus acidophilus and acetobacter；
D) preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L Water and plant material 0.5kg, the plant enzyme stoste for adding 150ml are fermented in closed environment, and fermentation temperature is 28 ~30 DEG C, deflate 1~2 time daily, after 1~2d of fermentation；Fermentation composition prepared by 30g step a) is added, fermentation temperature is not Become, continue the 3-4d that ferments, filtering produces plant enzyme.
Wherein, plant material selects passion fruit 120g, citrus 200g, grape 100g, Chinese yam 50g, pumpkin 220g, celery 40g, water spinach 50g, bean sprouts 50g, sea-tangle 60g, seaweed 40g and asparagus 70g.
Organoleptic parameters：The plant enzyme uniform color, in dark brown, has strong fruity and the fragrance that ferments, mellow in taste, Comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
The plant enzyme of embodiment 12
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition：Prepared according to the fermentation composition of embodiment 5；
B) preparation of plant extraction liquid：1kg plant material is cleaned, the sugared to plant material of 0.3~0.6kg weight is added In, and 5~6L pure water is added, it is well mixed, stands after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extract Liquid；
C) mixing and initial fermentation：The fermentation composition for the step a) preparations that weight is 30~60g is added into step b) Plant extraction liquid in, mixing is placed in closed environment, keeps 30 DEG C of fermentation temperature, carries out lucifuge fermentation, obtains initial fermentation liquid；
D) zymotic fluid carries out after-ripening 7d in closed environment, filtering, produces plant enzyme.
Wherein, plant material selects apple 500g, soybean 200g and tomato 300g.
Organoleptic parameters：The plant enzyme uniform color, in bronzing, has strong fruity and the fragrance that ferments, mellow in taste, Comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
The plant enzyme of embodiment 13
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition：Prepared according to the fermentation composition of embodiment 1；
B) mixed material：1kg plant material is cleaned, is put into the sugar of 0.3~0.6kg weight in ferment bucket, addition 5~ 6L pure water, is well mixed, while add in fermentation composition to the ferment bucket that weight is prepared for 20~50g step a), Capping, lucifuge fermentation is carried out in fermentation temperature is 28~30 DEG C of environment；
C) ferment：Fermentate in ferment bucket is carried out after stirring sooner or later once daily, 4~6d of fermentation, filtering is produced Plant enzyme.
Wherein, plant material selects apple 500g, soybean 200g and tomato 300g.
Organoleptic parameters：The plant enzyme uniform color, in bronzing, has strong fruity and the fragrance that ferments, mellow in taste, Comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
The plant enzyme of embodiment 14
The plant enzyme of the present embodiment is prepared from by following methods：
I the fermentation composition of pellet) is prepared according to embodiment 7
II) the preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of 1kg weight is added into plant material, and 10L pure water is added, is well mixed, is stood after 1~2d of extraction, high-temperature sterilization is carried out, filtering obtains plant extraction liquid；
III) the preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L water and plant extraction liquid 1kg, add 30g step II) prepare pellet fermentation composition, in closed environment carry out Fermentation；Fermentation temperature is 30~32 DEG C, is deflated 1~2 time daily；Ferment after 1~2d, insertion conduit is passed through air, daily ventilation 2-4 times, each 10-30min, and control fermentation temperature to be 35~37 DEG C；Filtered after 5~7d of fermentation, produce plant enzyme.
Wherein, plant material selects apple 500g, soybean 200g and tomato 300g.
Organoleptic parameters：The plant enzyme uniform color, in bronzing, has strong fruity and the fragrance that ferments, mellow in taste, Comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
Observation to the pellet fermentation composition fermentation process of embodiment 7：Pellet fermentation composition during the fermentation, ball The outer layer component of grain dissolves rapidly in the solution, and subsequent capsule core dissolving is slow, and coating membrane fades away after about 1-2d, and capsule core is completely molten Solution.
The fermentation composition of comparative examples 1
The prescription of the fermentation composition of the present embodiment is：
Functional oligose：Soyabean oligosaccharides 80g
Probiotics powder agent：24g, wherein containing 4.5 parts of Bifidobacterium, 1 part of lactobacillus bulgaricus, thermophilic in per g probiotic powders 2.3 parts of 2 parts of Lactobacillus lactis and lactobacillus paracasei；
Resistant dextrin 80g.
Preparation method：
(1) functional oligose of predetermined weight number, resistant dextrin are uniformly mixed, sterilized by heat exchanger, Condition is 99 DEG C, 300s；
(2) mixture is cooled to 40-45 DEG C after sterilizing, and the probiotics for adding scheduled volume is freeze-dried, is added after being well mixed Dry granulating machine is granulated, and the fermentation composition of powdery, sterile pack, every bag of 30g is made.
The plant enzyme of comparative examples 2
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition：Prepared by the fermentation composition of comparative examples 1；
B) preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight adds into plant material Enter 10L pure water, be well mixed, stand after extraction 2d, carry out high-temperature sterilization, filtering obtains plant extraction liquid；
C) preparation of plant enzyme stoste：Composite flora is inoculated with into plant extraction liquid, mixing is placed in closed environment, carried out Lucifuge is fermented 1~2 month, obtains plant enzyme stoste；
Wherein inoculum concentration is 12%；Composite flora is Lactobacillus plantarum, gram lactobacillus, lactobacillus acidophilus and acetic acid In bacillus；
D) preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L Water and plant material 0.5kg, the plant enzyme stoste for adding 150ml are fermented in closed environment, and fermentation temperature is 28 ~30 DEG C, deflate 1~2 time daily, after 1~2d of fermentation；Fermentation composition prepared by 30g step a) is added, fermentation temperature is not Become, continue the 3-4d that ferments, filtering produces plant enzyme.
Wherein, plant material selects apple 500g, soybean 200g and tomato 300g.
The plant enzyme of comparative examples 3
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of plant extraction liquid：1kg plant material is cleaned, the sugared to plant material of 0.3~0.6kg weight is added In, and 5~6L pure water is added, it is well mixed, stands after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extract Liquid；
B) mixing and initial fermentation：It is inoculated with plant extraction liquid of the compound probiotic into step b), mixing is placed in closed Environment, keeps 30 DEG C of fermentation temperature, carries out lucifuge fermentation, obtains initial fermentation liquid；
C) zymotic fluid carries out after-ripening 7d in closed environment, takes Partial fermentation liquid to filter, does organoleptic parameters；Continue after-ripening 14d, takes Partial fermentation liquid to filter, does organoleptic parameters.
Wherein, compound probiotic be Bifidobacterium, Lactobacillus rhamnosus, Lactobacillus casei,
Lactobacillus acidophilus and Lactobacillus plantarum；Inoculum concentration is 8% (mass percent)；
Plant material selects apple 500g, soybean 200g and tomato 300g.
The organoleptic parameters of zymotic fluid after 7 days：The plant enzyme color and luster is in bronzing, and tissue mobility is big, entrance slightly has Stimulation, sweet taste are heavier；The organoleptic parameters of zymotic fluid after 14 days：The plant enzyme uniform color, in bronzing, there is strong Fruity is not stimulated with fermentation fragrance, mellow in taste, comfortable acid, entrance, and pleasant impression is sweet.Understand, plant prepared by conventional method The fermentation time that ferment needs is longer than the fermentation time of the embodiment of the present invention.
Comparative examples 4
The prescription of the fermentation composition of the present embodiment is same as Example 1
Fermentation composition preparation method：
(1) preparation of Chinese medical extract：
The fructus cannabis of predetermined weight part, cassia seed, radish seed, lily, aloe, hawthorn, brush-cherry seed are respectively crushed into slightly Powder, the water of various 8 times of weight of coarse powder and mulberries keeps 4h at 80-90 DEG C of temperature, is then cooled to 40 DEG C, plus 2 times of weights The alcohol reflux 4h that concentration is 75% is measured, filtering obtains the first filtrate；The water of 3 times of weight of filter residue is added, at 80-90 DEG C of temperature 2.5h is kept, 30 DEG C is then cooled to, filters to obtain the second filtrate；Merging filtrate, is concentrated under reduced pressure, is freeze-dried, low-temperature grinding into It is ground into 0.05-0.2mm traditional Chinese medicine fine powder；
(2) functional oligose of predetermined weight number, probiotics powder agent, resistant dextrin are uniformly mixed, by mixed powder Dry granulating machine granulation is added, the granule of fermentation composition, pack, every bag of 30g is made.
Plant enzyme preparation method：Method according to embodiment 9 is prepared into plant enzyme.
Organoleptic parameters：The plant enzyme color and luster is uneven, muddy, has floating object, in bronzing, fruit flavor is thin, and entrance is not Stimulate.The viable bacteria survival detection of the fermentation composition of test example 1
Fermentation composition prepared by the embodiment of the present invention 1, embodiment 7 and comparative examples 4, is prepared with sterilized water and survived Bacterium number is 2 × 108CFU/mL solution to be measured, is saved backup in 4 DEG C；
The 10mL kept the solution to be measured of going bail for is injected into test tube 1, and 10 are diluted to step by step using ten times-8, take 1mL to dilute The MRS agar mediums that 45 DEG C are cooled to after sterilizing are poured on flat board (sterilizing), shaken up rapidly on flat board by liquid.Again will The test tube 2 of solution to be measured equipped with 10mL, which is placed in 80-90 DEG C of water-bath, heats 15-25min, takes the solution to be measured after heating to enter Row ten is diluted to 10 step by step again-8, 1mL dilutions are taken on flat board, and the MRS agar mediums that 45 DEG C are cooled to after sterilizing are poured into Shake up on flat board (sterilizing) and rapidly.Flat board before finally heating and after heating cultivates 24h under the conditions of 35 DEG C, calculates Number of viable before and after heating.
As a result show, Viable detection is respectively 89.8%, 90% and 62.4%.
The viable bacteria survival detection of the plant enzyme of test example 2
1st, simulate the gastric juice and the resistance test of intestinal juice
100g/L hydrochloric acid 16.4mL plus distilled water diluting is taken, it is respectively 1.5,2.5 and 3.5 to make pH value, take the dilute salt of 100mL Acid solution, is separately added into 1g pepsins, it is fully dissolved, and obtains simulate the gastric juice, and miillpore filter degerming (0.22 μm) is standby.Take Potassium dihydrogen phosphate 6.8g, the 500mL that adds water makes dissolving, and pH value is adjusted to 6.8 with 0.1moL/L sodium hydroxide solutions；Separately take tryptose Enzyme 10g, the 100mL that adds water makes dissolving, after two liquid are mixed, is diluted with water to 1000ml, obtains simulated intestinal fluid, miillpore filter is degerming (0.22 μm) is standby.
Embodiment 9 that 1mL is kept and the plant enzyme solution of embodiment 14 is taken to be added in 9mL simulate the gastric juice (i.e. ten Dilute step by step again), and rapid fully mixing on the oscillator, it is subsequently placed in 30-45 DEG C of quiescent culture 2-4h.Respectively 1h, 2h, Nutrient solution is taken out when 3h, 4h and remaining viable count is counted immediately, is compared, as a result shows with former viable count, viable bacteria is deposited Motility rate is respectively 98.3% and 98.5%.Then each 1mL of nutrient solution that different time is digested in simulated gastric fluid is taken, is inoculated with respectively In 9mL pH value in 6.8 simulated intestinal fluid, to be placed in 30-45 DEG C of quiescent culture 2-4h, and sample, survey in 0,3,6,24h respectively Its fixed viable count, is compared, it is 99% as a result to show Viable detection with former viable count.
The animal experiment that the plant enzyme of test example 3 relaxes bowel
Foundation《Health food is examined and assessment technique specification》Bowel relaxing functions detection method to embodiment 9, embodiment 11, real The plant enzyme that example 12, embodiment 13, embodiment 14, comparative examples 2 and comparative examples 3 prepare is applied to be commented Valency, it is specific as follows：
1st, test method：
1.1 experimental animals select adult female mice, body weight 18~22g, every group 10；Method is given for oral gavage and made Mould medicaments compound diphenoxylate, sets up Constipated mice, gavage prepared Chinese ink, determines first grain row's melena defecation time, 5 small of mouse When interior defecation grain number and defecation weight, to reflect the defecation situation of model mice.
1.2 packet situations are：
Group 1：The plant enzyme of gavage embodiment 9；
Group 2：The plant enzyme of gavage embodiment 11；
Group 3：The plant enzyme of gavage embodiment 12；
Group 4：The plant enzyme of gavage embodiment 13；
Group 5：The plant enzyme of gavage embodiment 14；
Group 6：The plant enzyme of gavage comparative examples 2；
Group 7：The plant enzyme of gavage comparative examples 3；
Above-mentioned group mouse is taken twice daily, and each 10ml takes after being diluted with warm water；
Group 8：Model control group, the physiological saline of gavage equivalent；
Group 9：Blank control group, the physiological saline of gavage equivalent.
The foundation of 1.3 models
After given the test agent 7 days, each group mouse fasting can't help water 16 hours.
9 blank control groups of group give compound diphenoxylate to distilled water, 1~8 gavage of group.
The specific method of 1.4 index determinings
Group 1~8 is to compound diphenoxylate after 0.5 hour, and group 1~9 gives mouse prepared Chinese ink gavage, and the equal single cage of animal is raised Support, normal water feed, since being filled prepared Chinese ink, record in every small mouse's head grain row's melena time, 5 hours row's melena grain number and again Amount.
2nd, result of the test：
Concrete outcome is shown in Table 1.
The each group mouse defecation result of table 1
From the above results, the effect that the plant enzyme of group 1 and group 5 relaxes bowel is more notable, even better than organizes 9 Blank control group, plant enzyme effect prepared by the no added traditional Chinese medicine ingredients fermentation composition of group 6 is worst, as a result shows, group 1 and group The effect of plant enzyme prepared by the fermentation composition of 5 formulas substantially than other formulas is more notable.
The human feeding trial that the plant enzyme of test example 4 relaxes bowel
1st, test method：
The patient that selection 84 suffers from constipation, the curative effect to medicine of the present invention is observed.
Diagnostic criteria：One week less than 3 times persons of stool, without organic constipation person and habitual constipation person.
Subject is randomly divided into 4 groups, every group of 21 people, packet situation is：
Group 1：The plant enzyme of gavage embodiment 9；
Group 2：The plant enzyme of gavage embodiment 13；
Group 3：The plant enzyme of gavage embodiment 14；
Group 4：The plant enzyme of gavage comparative examples 2.
Group 1~4 is taken twice daily, and each 60ml takes 7 days after being diluted with warm water.Between experimental period diet with Amount of exercise with being consistent before experiment, indices in test-meal test start and at the end of each test once.
2nd, observation index：
2.1 efficiency index：Subject is inquired and recorded daily, is taken while recording subject before given the test agent 6 days and experiment when situation；The change of defecation frequency before and after record subject's test-meal.
2.2 defecation condition：(suffered from abdominal pain or anus burn feeling, bearing down, sense of discomfort, whether just frequently according to difficult defecation degree But difficult defecation and measure the symptom such as few) be divided into I-IV grade, statistics integrated value.
I grades (0 point)：Defecation is normal；
II grades (1 point)：Only bearing down, sense of discomfort；
III level (2 points)：Bearing down, sense of discomfort substantially, or have just frequency but a difficult defecation and measure it is few, it is less occur suffering from abdominal pain or Anus burn feeling；
IV grades (3 points)：Often occur suffering from abdominal pain or anus burn feeling, influence defecation.
2.3 excrement states：It is divided into I-III grades according to Bristol fecal character classification.
I grades (0 point)：It is smooth and soft as sausage or snake；As sausage, there is slight crack on surface；Soft agglomerate, some limbus (being easily drained)；
II grades (1 point)：Sausage shape, but have agglomerate；Loose bulk, edge roughness, as slimy excrement；
III level (2 points)：The hard group of separation, as fruit stone (should not be discharged).
3rd, result of the test
Each group case comparitive study the results are shown in Table 2.
Defecation result after the test-meal of table 2
From the above results, the group 1-3 plant enzyme effect that relaxes bowel is shown as significantly, and best results is organize 1 With group 3；And the plant enzyme effect for organizing 4 no added traditional Chinese medicine ingredients fermentation compositions preparations is poor.
Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that：Not In the case of departing from the principle and objective of the present invention a variety of change, modification, replacement and modification can be carried out to these embodiments, this The scope of invention is limited by claim and its equivalent.

Claims (10)

1. a kind of fermentation composition for preparing the plant enzyme with recuperating gastrointestinal tract function of relaxing bowel, it is characterised in that should Fermentation composition is direct putting type plant enzyme fermenting agent, and the fermentation composition includes the component of following parts by weight：It is prebiotic 0.01~10 part of 0.1~5 part of bacterium and Chinese medical extract,
Wherein, the probiotics is one or more of jellies in Bifidobacterium, lactobacillus and streptococcus thermophilus Dry powder；
The Chinese medical extract is extracted by the raw material of following parts by weight and formed：0.3~2 part of fructus cannabis, 0.5~2.6 part certainly Pine torch, 0.1~1.6 part of radish seed, 0.2~2 part of lily, 0.1~1.2 part of aloe, 0.3~2 part of hawthorn, 0.1~ 1.4 parts of brush-cherry seed and 0.3~2 part of mulberries；
The preparation method of the fermentation composition at least comprises the steps：
The particulate fine powder that the functional oligose and Chinese medical extract of predetermined weight number are made uniformly mixes sterilization, after sterilization It is well mixed, granulates with probiotic powder, the fermentation composition of powdery is made.
2. fermentation composition as claimed in claim 1, it is characterised in that the fermentation composition also includes functional oligose 3~22 parts.
3. fermentation composition as claimed in claim 2, it is characterised in that the fermentation composition is 5~10 by parts by weight The functional oligose, 1~3 part of probiotics and 0.5~1 part of Chinese medical extract composition of part；
The Chinese medical extract is extracted by the raw material of following parts by weight and formed：0.9~1.4 part of fructus cannabis, 1~1.5 part certainly Pine torch, 0.4~0.9 part of radish seed, 0.6~1.2 part of lily, 0.3~0.6 part of aloe, 0.9~1.2 part of hawthorn, 0.6~0.9 part of brush-cherry seed and 0.9~1.4 part of mulberries；
The functional oligose is selected from chitosan, xylo-oligosaccharide, kanjak mannan-oligosaccharides, mannan-oligosaccharides, milk ketose, cotton Seed sugar, soyabean oligosaccharides, FOS, galactooligosaccharide, lactosucrose, konjac mannan sugar, trehalose, palatinose and One or more in inulin；
The Bifidobacterium includes one kind in bifidobacterium longum, bifidobacterium breve, bifidobacterium infantis and bifidobacterium lactis Or it is several；
The lactobacillus include Lactobacillus rhamnosus, Lactobacillus casei, lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus salivarius, Lactobacillus helveticus, Bu Shi lactobacillus, lactobacillus bulgaricus, lactobacillus paracasei and one kind or several in lactobacillus reuteri Kind.
4. fermentation composition as claimed in claim 1, it is characterised in that it is 10 that the fermentation composition, which also includes parts by weight, ~30 parts of resistant dextrin.
5. fermentation composition as claimed in claim 1, it is characterised in that the functional oligose is soyabean oligosaccharides；
The probiotics is probiotics powder agent, is uniformly mixed by the pulvis of following parts by weight：4.5~6 parts of Bifidobacterium, 2.3~3 parts of 1~2.6 part of lactobacillus bulgaricus, 2~2.8 parts of lactobacillus acidophilus and lactobacillus paracasei, the probiotics The viable bacteria content of pulvis is 2 × 106~2 × 1010cfu/g。
6. such as fermentation composition according to any one of claims 1 to 5, it is characterised in that the fermentation composition also includes Parts by weight are 1~3 part of saccharomycete, 1~3 part of acetobacter and 1~5 part of lactic acid bacteria；
The preparation method of the fermentation composition also includes：
(1) softwood is made in the fermentation composition of the powdery of 1/2 amount, is well mixed with the lactic acid bacteria of the parts by weight laggard Row extrusion makes ball, and capsule core is made；
(2) fermentation composition of the powdery of 1/2 amount is well mixed with the saccharomycete and acetobacter of the parts by weight, made It is standby into softwood thing；
(3) obtained capsule core is placed in the coating solution prepared in advance, be coated；
(4) the round as a ball extruding in the softwood thing of step (2) to the coating capsule core after Cotton seeds, then be dried, produce pellet Fermentation composition；
Wherein, the coating solution is by the adjacent benzene for 100-55,0.1-2 parts of the Eudragit L that parts by weight are 0.4-10 parts Dioctyl phthalate hydroxypropyl methyl cellulose and 0.05-0.2 parts of castor oil add the aqueous dispersion that appropriate purified water is configured to.
7. a kind of preparation method of fermentation composition as claimed in claim 4, it is characterised in that methods described includes following step Suddenly：
1) preparation of Chinese medical extract：
The fructus cannabis of predetermined weight part, cassia seed, radish seed, lily, aloe, hawthorn, brush-cherry seed are respectively crushed into coarse powder, respectively The water of kind of 8 times of weight of coarse powder and mulberries, 4h is kept at 80-90 DEG C of temperature, is then cooled to 40 DEG C, plus 2 times of weight are dense The alcohol reflux 4h for 75% is spent, filters, obtains the first filtrate；The water of 3 times of weight of filter residue is added, is kept at 80-90 DEG C of temperature 2.5h, is then cooled to 30 DEG C, filters to obtain the second filtrate；Merging filtrate, is concentrated under reduced pressure, is freeze-dried, and low-temperature grinding is into crushing Into 0.05-0.2mm traditional Chinese medicine fine powder；
2) by step 1) in traditional Chinese medicine fine powder mixed with emulsifying agent, water after carried out with cutter 3000-5000 turn high speed shear, Wall material monomer is added dropwise while stirring and carries out wall building, nano level Chinese medicine particulate is formed；
3) by the functional oligose, resistant dextrin and step 2 of predetermined weight number) in Chinese medicine particulate uniformly mix, pass through Heat exchanger is sterilized, and condition is 99 DEG C, 300s；
4) mixture is cooled to 40-45 DEG C after sterilizing, and the probiotics for adding scheduled volume is freeze-dried, and adding dry method after being well mixed makes Grain machine granulation, is made the fermentation composition of powdery, sterile packing is produced.
8. the preparation side of the plant enzyme with recuperating gastrointestinal tract function of relaxing bowel any one of a kind of claim 1-5 Method, it is characterised in that the described method comprises the following steps：
(a) powdery fermentation composition is prepared
(b) mixed material：1kg plant material is cleaned, is put into the sugar of 0.3~0.6kg weight in ferment bucket, adds 5~6L Pure water, be well mixed, at the same add weight be 20~50g the step of (a) prepare fermentation composition to ferment bucket in, envelope Lid, lucifuge fermentation is carried out in fermentation temperature is 28~30 DEG C of environment；
(c) ferment：Fermentate in ferment bucket is carried out after stirring sooner or later once daily, 5~8d of fermentation, filtering produces plant Thing ferment.
9. the preparation side of the plant enzyme with recuperating gastrointestinal tract function of relaxing bowel any one of a kind of claim 1-5 Method, it is characterised in that the described method comprises the following steps：
A) fermentation composition of powdery is prepared
B) preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight is added into plant material 10L pure water, is well mixed, and stands after 1~2d of extraction, carries out high-temperature sterilization, and filtering obtains plant extraction liquid；
C) preparation of plant enzyme stoste：Composite flora is inoculated with into plant extraction liquid, mixing is placed in closed environment, carries out lucifuge Fermentation 1~2 month, obtains plant enzyme stoste；
Wherein inoculum concentration is 8~12%；Composite flora is saccharomyces cerevisiae, the newborn subspecies of Lactobacillus delbrueckii, Lactobacillus plantarum, gram It is several in lactobacillus, lactobacillus acidophilus and acetobacter；
D) preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L water with And plant material 0.5kg, add 150ml plant enzyme stoste fermented in closed environment, fermentation temperature be 28~30 DEG C, deflate 1~2 time daily, after 1~2d of fermentation；Fermentation composition prepared by 30g step a) is added, fermentation temperature is constant, after Supervention ferment 3-4d, filtering, produces plant enzyme.
10. the preparation method of the plant enzyme with recuperating gastrointestinal tract function of relaxing bowel, its feature described in a kind of claim 6 It is, the described method comprises the following steps：
I the fermentation composition of pellet) is prepared
II) the preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight is added into plant material 10L pure water, is well mixed, and stands after 1~2d of extraction, carries out high-temperature sterilization, and filtering obtains plant extraction liquid；
III) the preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L water And plant extraction liquid 1kg, add 30g step II) prepare pellet fermentation composition, sent out in closed environment Ferment；Fermentation temperature is 30~32 DEG C, is deflated 1~2 time daily；Ferment after 1~2d, insertion conduit is passed through air, and ventilate 2-4 daily It is secondary, each 10-30min, and control fermentation temperature to be 35~37 DEG C；Filtered after 5~7d of fermentation, produce plant enzyme.
CN201710233948.5A 2017-04-11 2017-04-11 Prepare the fermentation composition and preparation method of the plant enzyme with recuperating gastrointestinal tract function of relaxing bowel Pending CN107048360A (en)

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CN108477460A (en) * 2018-04-18 2018-09-04 湖南喜玫瑰医药生物科技有限公司 A kind of composition and preparation method thereof having effect of relaxing bowel
CN109832534A (en) * 2018-08-01 2019-06-04 北京姿美堂生物技术有限公司 A kind of functional garden stuff ferment solid beverage and preparation method thereof
CN109985115A (en) * 2019-05-23 2019-07-09 河南中医药大学 A kind of Chinese medicine tea bag for treating constipation
CN110013443A (en) * 2019-01-22 2019-07-16 名臣健康用品股份有限公司 A kind of Chinese medicine composition toothpaste containing functional oligose
CN111035660A (en) * 2020-01-13 2020-04-21 刘敏 Polygonal gastric mucosa probiotic powder with good absorption effect
CN111213875A (en) * 2018-12-24 2020-06-02 国润民富科技发展有限公司 Preparation method of cerasus humilis composite Chinese herbal medicine enzyme cream with functions of dispelling effects of alcohol and protecting liver
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CN107495049A (en) * 2017-10-17 2017-12-22 广东达明益派生物科技有限公司 Composition for preparing probiotic fermented fruit and vegetable beverage with intestine moistening and bowel relaxing functions, beverage containing composition and preparation method of beverage
CN107874251A (en) * 2017-11-14 2018-04-06 广东健来福云健康科技股份有限公司 A kind of eight delicacies probiotic composition with strengthening the spleen and stomach benefit function of intestinal canal
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CN108477460A (en) * 2018-04-18 2018-09-04 湖南喜玫瑰医药生物科技有限公司 A kind of composition and preparation method thereof having effect of relaxing bowel
CN109832534A (en) * 2018-08-01 2019-06-04 北京姿美堂生物技术有限公司 A kind of functional garden stuff ferment solid beverage and preparation method thereof
CN111213875A (en) * 2018-12-24 2020-06-02 国润民富科技发展有限公司 Preparation method of cerasus humilis composite Chinese herbal medicine enzyme cream with functions of dispelling effects of alcohol and protecting liver
CN110013443A (en) * 2019-01-22 2019-07-16 名臣健康用品股份有限公司 A kind of Chinese medicine composition toothpaste containing functional oligose
CN109985115A (en) * 2019-05-23 2019-07-09 河南中医药大学 A kind of Chinese medicine tea bag for treating constipation
CN109985115B (en) * 2019-05-23 2021-07-23 河南中医药大学 Traditional Chinese medicine tea bag for treating constipation
CN111035660A (en) * 2020-01-13 2020-04-21 刘敏 Polygonal gastric mucosa probiotic powder with good absorption effect
CN114468280A (en) * 2022-03-04 2022-05-13 国珍健康科技（北京）有限公司 Enzyme for preventing obesity and regulating intestinal flora and preparation method and application thereof
CN114601157A (en) * 2022-03-17 2022-06-10 上海兆一医疗科技有限公司 Food additive for promoting defecation
CN116622587A (en) * 2023-06-27 2023-08-22 深圳市波尔顿科技有限公司 Probiotic prepared by synthetic biological method, composition and application thereof
CN116622587B (en) * 2023-06-27 2023-09-19 深圳市波尔顿科技有限公司 Probiotic prepared by synthetic biological method, composition and application thereof

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