CN106962937A - Prepare fermentation composition and preparation method with prevention conditioning hypertension, high fat of blood, hyperglycaemia and routine servicing effect plant enzyme - Google Patents
Prepare fermentation composition and preparation method with prevention conditioning hypertension, high fat of blood, hyperglycaemia and routine servicing effect plant enzyme Download PDFInfo
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides the fermentation composition with prevention conditioning hypertension, high fat of blood, hyperglycaemia and routine servicing effect plant enzyme is prepared, it is made up of functional oligose, probiotics and Chinese medical extract；Additionally provide the plant enzyme of fermentation composition preparation method and its preparation.The fermentation composition is novel fermentation product, is that the bacterium bag is easy to use for preparing ferment " fermentation bacterium bag ", the industrialized production of suitable all kinds of plant enzymes.
Description
Technical field
The invention belongs to prevent conditioning maintenance product field, more particularly to one kind is prepared with prevention conditioning hypertension, high blood
The fermentation composition and preparation method of fat, hyperglycaemia and routine servicing effect plant enzyme.
Background technology
Ferment, also known as " enzyme ", ferment participate in all vital movements of human body：Such as think deeply, move, sleep, breathing, anger
Anger, happiness or secretion hormone etc. are all the action results centered on ferment.Plant enzyme is always ferment class product
Best seller.Plant enzyme is by plants such as tens of kinds of different vegetables and fruits, cereal, seaweeds and mushroom classes, through spontaneous fermentation development
Into, the nutrition elite in plant is remained, various ferment, oligosaccharides and a variety of vitamins and the mineral matter needed containing human body, again
Abundant SOD antioxidase compositions can be produced, internal oxidation resistance, and then strengthen immunity is improved.
Existing traditional handicraft and modern crafts to ferment has all done further improvement, while also occurring in that some addition benefits
Health food prepared by the ferment and ferment of raw bacterium.Probiotics fermention fruits and vegetables, can activate the effective efficiency composition in fruits and vegetables, molten
Go out active effect material of more elite.The heart, cerebrovascular metabolic function plant ferment can be improved as disclosed in patent CN103355666A
In the preparation method of plain drink, using various plants as Solution culture method base, using compound probiotic as conversion instrument, sent out using liquid
Drink prepared by ferment technique, record can improve body metabolism disorder, and prevention of cardiovascular disease reduces " three high ".But the patent
Formula components it is complicated, and can not be on a large scale flexibly using or being used in the industrial manufacturing processes of different ferment；In order to carry
Effect of the high ferment in terms of metabolism, coordinating intestines and stomach function in vivo is promoted, and adapt to use on a large scale, applicant
The fermentate for preparing ferment is further improved, and develops the formula for the function affect for improving ferment.
There is physiologically active, not by human body hydrochloric acid in gastric juice, gastric enzyme degraded in addition, functional oligose is a class, do not inhaled in small intestine
Receive, reach the oligosaccharide of big intestines；Oligosaccharide is prebiotics, is the substrate of the growth of probiotics, and with promoting, human body is prebiotic
The physiological functions such as the propagation of bacterium.By the way that probiotics and functional oligose are used in conjunction with, between the two with synergy, energy
Promote the regulatory function to gut flora.Co between probiotics and oligosaccharide, be probiotic in symphysis unit and
Co between prebiotics, they complement each other, and play a role jointly, promote beneficial bacterium growing multiplication, suppress harmful bacteria
Growth；Research shows that both uses can increase the quantity of Bifidobacterium in healthy human faecal mass, but individually take probiotics and have no
This effect.
Based on above-mentioned technology, the artificial feature for improving ferment of application is added with the ferment fermentate of prior art
The traditional Chinese medicine ingredients of effect, enable its ferment prepared effectively to adjust gut flora, strengthen immunity, and have function.
On the other hand, existing ferment bucket, prepares plant enzyme so that plant enzyme using fruit, sugar and water as raw material
It can be prepared in family, it is easy to operate.But also having many weak points, the time prepared by 1. ferment is still longer, Er Qierong
Easily prepare failure；2. made from plant enzyme effect it is indefinite, user can not oneself control prepare effect of plant enzyme, than
Such as there is the plant enzyme of reduction " three high " effect；3. the low molecular sugar and polysaccharide majority in the plants such as fruit can not be utilized, no
The oligosaccharide of given efficacy can be converted into.For the deficiency, applicant, which puts forth effort research, to be had shortening ferment preparation time, uses
Fermentation composition convenient and with prevention or reduction " three high " effect, i.e. ferment bag.
The content of the invention
It is contemplated that at least solving one of technical problem present in prior art.Therefore, one object of the present invention
It is to propose a kind of fermentation for preparing and nursing one's health hypertension, high fat of blood, hyperglycaemia and routine servicing effect plant enzyme with prevention
Composition, the fermentation composition is directly putting type fermented microbial inoculum, and probiotics and functional oligose are used in combination, while in addition
Medicine composition, makes said composition while with good gut flora regulatory function, can promote small molecular sugar and polysaccharide to
The conversion of oligosaccharide.The plant enzyme prepared with the fermentation composition plays effect of prevention or treatment " three high ", and to " three
Height " crowd has effects that routine servicing.
Technical scheme is as follows：
It is a kind of to prepare the fermentation with prevention conditioning hypertension, high fat of blood, hyperglycaemia and routine servicing effect plant enzyme
Composition, the fermentation composition is direct putting type plant enzyme fermenting agent, and the fermentation composition includes following parts by weight
Component：0.01~10 part of 3~22 parts of functional oligose, 0.1~5 part of probiotics and Chinese medical extract,
Wherein, the probiotics is the one or more in Bifidobacterium, lactobacillus and streptococcus thermophilus
Freeze-dried powder；
Every part of Chinese medical extract is extracted by the raw material of following parts by weight and formed：0.3~2 part of matrimony vine, 0.5~3 part
Mulberries, 0.1~1.6 part of sea-buckthorn, 0.5~3 part of the root of kudzu vine, 0.3~2 part of the stem of noble dendrobium and 0.5~3 part of cassia seed；
The preparation method of the fermentation composition at least comprises the steps：
The fine powder that the functional oligose and Chinese medical extract of predetermined weight number are made is sterilized after mixing, after sterilization with
Probiotics powder agent is uniformly mixed, granulation, and the fermentation composition of powdery is made.
Probiotics and functional oligose reasonable combination are used, and both have mutual promoting action, can be doubled to enteron aisle
The regulatory function of flora, so that the effect based on gut flora plays more preferable strengthen immunity；And the traditional Chinese medicine ingredients added, enter
The effects such as one step realizes prevention or treatment obesity, diabetes, hypertension, high fat of blood or tumour.On the other hand, by fermentation composition
Be made powdery, the production of implementation phase formula, be easy to the later stage direct plunge into use or family oriented is used.
Further, functional oligose of the fermentation composition by parts by weight for 5~10 parts, 1~3 part prebiotic
Bacterium and 0.5~1 part of Chinese medical extract composition.
Further, Chinese medical extract is extracted by the raw material of following parts by weight and formed：0.9~1.2 part of matrimony vine, 1.2~
1.5 parts of mulberries, 0.6~1.1 part of sea-buckthorn, 1.2~1.5 parts of the root of kudzu vine, 0.9~1.2 part of the stem of noble dendrobium and 1~1.3 part
Cassia seed.
In such scheme, the functional oligose is selected from chitosan, xylo-oligosaccharide, kanjak mannan-oligosaccharides, sweet dew
Oligosaccharide, milk ketose, raffinose, soyabean oligosaccharides, FOS, galactooligosaccharide, lactosucrose, konjac mannan sugar,
One or more in trehalose, palatinose and inulin；
Bifidobacterium includes bifidobacterium longum (B.longum), short Bifidobacterium Bifidum (B.breve) (B.breve), bifidobacterium infantis
And the one or more in bifidobacterium lactis (B.ifidobacterium) (B.infantis)；
Lactobacillus includes Lactobacillus rhamnosus (L.rhamnosus), Lactobacillus casei (Lactobacillus
Casei), lactobacillus acidophilus (L.acidophilus), Lactobacillus plantarum (Lactobacillus plantarum), the newborn bar of saliva
Bacterium (Lactobacillus salivarius), Lactobacillus helveticus (Lactobacillus helveticus), Bu Shi lactobacillus
(Lactobacillus buchneri), lactobacillus bulgaricus (Lactobacillus.Bulgaricus), the newborn bar of secondary cheese
One kind or several in bacterium (Lactobacillus paracasei) and lactobacillus reuteri (Lactobacillus reuteri)
Kind.
The preferred scheme of the fermentation composition of the present invention, in addition to the maltodextrin that parts by weight are 10~30 parts, malt
Dextrin is used in conjunction with other components, further promotes intestines peristalsis, keeps intestinal health, and control the absorption of grease and sugar.
Further, oligoisomaltose, 0.015-0.05 of the functional oligose by parts by weight for 8-10 parts
The chitosan of part and 0.06-0.1 parts of xylo-oligosaccharide composition；
The probiotics is probiotics powder agent, is uniformly mixed by the pulvis of following parts by weight：Bifidobacterium 45~
60 parts, 20~25 parts of Lactobacillus rhamnosus, 12~16 parts of Lactobacillus casei, 14~18 parts of lactobacillus acidophilus and Lactobacillus plantarum
23~30 parts, the viable bacteria content of the probiotics powder agent is 2 × 108~8 × 108cfu/g；By all kinds of strains of reasonable disposition and
Consumption, optimizes the strain of this patent products'texture, can effectively shorten fermentation composition in the time for preparing plant enzyme, and can make
It prepares the stable plant enzyme of texture.
The source of above-mentioned all kinds of probiotics powder agents：It is the pulvis of commercially available all kinds of strains or by will be commercially available all kinds of
Strain is collected by centrifugation with after washing thalline, drying is prepared into active powder through Liquid Culture.
In another inventive technique scheme, fermentation composition of the invention also includes the acetic acid that parts by weight are 1~5 part
Bacillus and 1~5 part of lactic acid bacteria；
The preparation method of the fermentation composition also includes：
(1) softwood is made in the fermentation composition of the powdery of 1/2 amount, is well mixed with the lactic acid bacteria of the parts by weight
Extrusion is carried out afterwards and makes ball, and capsule core is made；
(2) fermentation composition of the powdery of 1/2 amount is well mixed with the acetobacter of the parts by weight, be made soft
Material thing, it is standby；
(3) obtained capsule core is placed in the coating solution prepared in advance, be coated；
(4) the round as a ball extruding in the softwood thing of step (2) to the coating capsule core after Cotton seeds, then be dried, produce
Pellet fermentation composition；
Wherein, the coating solution is by the adjacent benzene for the acroleic acid resin No. II, 0.05-1 parts that parts by weight are 0.4-10 parts
Dicarboxylate and 0-5 parts of castor oil add the aqueous dispersion that appropriate purified water is configured to.
As above, the fermentation pill with double-layer structural is prepared into, outer layer fermentation ball is mixed with acetobacter, internal layer fermentation ball
Lactic acid bacteria is mixed with, the step of eliminating post incoulation composite bacteria improves the convenience that product is used；And lead between ectonexine
The time limit that internal layer pill starts dissolving can effectively be extended by crossing coating membrane and separate, and reach two-stage inoculation ferment effect, be realized deep
Layer liquid state fermentation.
The preparation method of the fermentation composition of powdery of the present invention, comprises the following steps：
1) preparation of Chinese medical extract：
The root of kudzu vine and cassia seed of the parts by weight are crushed respectively, 60 mesh sieves are crossed, root of kudzu vine powder and Cassia Seed is made；
By root of kudzu vine powder, the matrimony vine of Cassia Seed and predetermined weight part, mulberries, sea-buckthorn, 8 times of weight of the stem of noble dendrobium water,
4h is kept at 80-90 DEG C of temperature, 40 DEG C, plus the alcohol reflux 4h that 2 times of weight concentrations are 75%, filtering is then cooled to, obtains
First filtrate；Add the water of 3 times of weight of filter residue, 2.5h kept at 80-90 DEG C of temperature, be then cooled to 30 DEG C, filtering, the
Two filtrates；Merging filtrate, is concentrated under reduced pressure, is freeze-dried, and low-temperature grinding is into the traditional Chinese medicine fine powder for being ground into 0.05-0.2mm；
2) by step 1) in traditional Chinese medicine fine powder mixed with emulsifying agent, water after carry out high speed shear with cutter, form particle
Particle diameter is less than 50 microns of Chinese medicine particulate；
3) by the functional oligose, maltodextrin and step 2 of predetermined weight number) in Chinese medicine particulate uniformly mix,
Sterilized by heat exchanger, condition is 99 DEG C, 300s；
4) mixture is cooled to 40-45 DEG C after sterilizing, and the probiotics for adding scheduled volume is freeze-dried, is added after being well mixed dry
Method comminutor is granulated, and the fermentation composition of powdery is made, and sterile packing is produced.
Fermentation composition viable bacteria rate prepared by the above method is high, the traditional Chinese medicine fine powder delicate mouthfeel of particulate processing, the plant of preparation
Thing ferment is without muddy thing, and color and luster is pure.
A further object of the present invention, which is to provide, a kind of to be had prevention conditioning hypertension, high fat of blood, hyperglycaemia and daily supports
The plant enzyme of effect is protected, the plant enzyme is, for raw material, to add the fermentation composition of preceding claim with plant and sugar,
By made from liquid state fermentation culture process.
The preferred scheme of the present invention, is formulated for personal or Homemade plant enzyme, plant enzyme
Preparation method comprises the following steps：
(a) powdery fermentation composition is prepared
(b) mixed material：1kg plant material is cleaned, is put into the sugar of 0.3~0.6kg weight in ferment bucket, adds 5
~6L pure water, be well mixed, while add weight be 20~50g the step of (a) prepare fermentation composition to ferment bucket
Interior, capping carries out lucifuge fermentation in fermentation temperature is 28~30 DEG C of environment；
(c) ferment：Fermentate in ferment bucket is carried out after stirring sooner or later once daily, 5~8d of fermentation, filtering, i.e.,
Obtain plant enzyme.
This method simple and fast, realizes the self-control of various functions plant enzyme, and this method preferably uses ferment bucket and made
Standby, ferment bucket is from market sale；Also the vessel of closed environment can be used to be prepared.
Another preferred scheme of the preparation method of plant enzyme of the present invention, comprises the following steps：
A) fermentation composition of powdery is prepared
B) preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight adds into plant material
Enter 10L pure water, be well mixed, stand after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extraction liquid；
C) preparation of plant enzyme stoste：Composite flora is inoculated with into plant extraction liquid, mixing is placed in closed environment, carried out
Lucifuge is fermented 1~2 month, obtains plant enzyme stoste；
Wherein inoculum concentration is 8~12%；Composite flora is saccharomyces cerevisiae, the newborn subspecies of Lactobacillus delbrueckii, Lactobacillus plantarum, leather
It is several in Lan Shi lactobacillus, lactobacillus acidophilus and acetobacter；
D) preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L
Water and plant material 1kg, add fermentation composition prepared by 150ml plant enzyme stoste and 30g step a), in closed
Fermented in environment, fermentation temperature is 28~30 DEG C, is deflated 1~2 time daily, after 4~6d of fermentation, filtering produces plant ferment
Element.
The preferred scheme of the preparation method of another plant enzyme, the use of the fermentation composition also constructed for double-deck pellet
Method, the preparation method comprises the following steps：
I the fermentation composition of pellet) is prepared
II) the preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of 1kg weight is added into plant material, and
10L pure water is added, is well mixed, is stood after 1~2d of extraction, high-temperature sterilization is carried out, filtering obtains plant extraction liquid；
III) the preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g,
8L water and plant extraction liquid 1kg, add 30g step II) prepare pellet fermentation composition, in closed environment carry out
Fermentation；Fermentation temperature is 30~32 DEG C, is deflated 1~2 time daily；Ferment after 1~2d, insertion conduit is passed through air, daily ventilation
2-4 times, each 10-30min, and control fermentation temperature to be 35~37 DEG C；Filtered after 5~7d of fermentation, produce plant enzyme.
The present invention has the following advantages that compared with prior art：
The fermentation composition that the present invention is developed is novel fermentation product, is for preparing ferment " fermentation bacterium bag ", improveing
Direct addition probiotics prepares the traditional handicraft of plant enzyme, and the bacterium bag is easy to use, can directly with the bacterium bag of pulvis in city
Sold on face, can also put into the industrialized production of all kinds of plant enzymes, realize matching somebody with somebody i.e. with the work(with diversification for plant enzyme
Energy property configuration, is greatly enhanced the preparation efficiency of plant enzyme.
The traditional Chinese medicinal components added in the fermentation composition of the present invention have its physiologically active and health-care effect, while being prebiotic
Bacterium supplements the nutrients in fermentation, and high blood can effectively be prevented or be treated to the traditional Chinese medicine ingredients with higher practical value, and the present invention
The diseases such as pressure, high fat of blood and hyperglycaemia；Rationally, curative effect is bright for compatibility between probiotics, functional oligose and Chinese medicine each component
Really, the effect with Synergistic.
The plant enzyme of the present invention meets requirement and the development trend of health products, and plant enzyme can be produced largely to be had to human body
The comprehensive plant enzyme of benefit, metabolism and function adjustment of these enzymes to human body plays an important role, while also containing vitamin, mineral
The nutritional ingredients such as matter, amino acid, organic acid, oligosaccharide.The present invention is fermented by adding above-mentioned fermentation composition, fermentation group
Traditional Chinese medicine ingredients in compound are changed through probiotics, are become small molecule by macromolecular, are easily absorbed by the body；The addition of probiotics can
Toxicity can be decomposed by improving in Chinese medicine taste, fermentation process, realization really has no toxic side effect, while prepared by the fermentation composition
Plant enzyme improves serum total cholesterol, the glycerine three in drug effect, the reduction blood of energy highly significant compared to traditional Chinese medicine
The content of ester, increases hdl level, adjusts gut flora.The suitable hyperglycaemia blood fat of the plant ferment, obese people with
And elderly population is used, taken as daily drinks, lipid-metabolism is improved from the angle effected a permanent cure, improve body immunity etc., it is real
The purpose of existing health care.
In addition, the technical process that the direct addition of fermentation composition prepares plant enzyme is simple, it is with low cost, it is easy to accomplish big
Large-scale production, compared to prior art, shortens the time for preparing and fermenting, and safe preparation process.
The source of the Chinese medicine material composition of the present invention：
Matrimony vine：This product is plant of Solanaceae lycium barbarum Lycium barbarum L. dry mature fruit.
Mulberries：This product is moraceae plants mulberry Morus alba L. drying fruit ear.
Sea-buckthorn：This strain Mongols, Tibetan conventional crude drugs.For Elaeangnaceae hippophae plant sea-buckthorn Hippophae
Rhamnoides L. dry mature fruit.
The root of kudzu vine：This product is legume pueraria lobata Pueraria lobata (Willd.) Ohwi or sweet kudzu Pueraria
Thomsonii Benth. dry root.
The stem of noble dendrobium：This product is orchid dendrobium loddigesii Rolfe Dendrobium loddigesii Rolfe., stem of Eyeshaped Dendrobium
Dendrobium fimbriatum Hook.var.oculatum Hook., HERBA DENDROBII Dendrobium chrysanthum
Wall., dendrobium candidum Dendrobium candidum Wall.ex Lindl. or HERBA DENDROBII Dendrobium nobile
Lindl. fresh or dry stem.
Cassia seed：This product is legume Cassia Cassia obtusifolia L. or little Cassia tora Cassia tora L.
Dry mature seed.
Embodiment
The fermentation composition of embodiment 1
The prescription of the fermentation composition of the present embodiment is：
Functional oligose：Oligoisomaltose 80g chitosan 0.15g xylo-oligosaccharides 0.6g
Probiotics powder agent：24.225g, wherein in per g probiotic powders containing 4.5 parts of Bifidobacterium, 2 parts of Lactobacillus rhamnosus,
1.6 parts of Lactobacillus casei, 1.8 parts of lactobacillus acidophilus, 2.3 parts of Lactobacillus plantarum；
Traditional Chinese medicine ingredients：8.075g, is formed wherein being extracted per g Chinese medical extracts by the raw material of following portions by weight：Matrimony vine 0.9
1 part of part, 1.2 parts of mulberries, 0.6 part of sea-buckthorn, 1.2 parts of the root of kudzu vine, 0.9 part of the stem of noble dendrobium and cassia seed；
Maltodextrin 80.75g
Preparation method：
(1) preparation of Chinese medical extract：
The root of kudzu vine and cassia seed of the parts by weight are crushed respectively, 60 mesh sieves are crossed, root of kudzu vine powder and Cassia Seed is made；
By root of kudzu vine powder, the matrimony vine of Cassia Seed and predetermined weight part, mulberries, sea-buckthorn, 8 times of weight of the stem of noble dendrobium water,
4h is kept at 80-90 DEG C of temperature, 40 DEG C, plus the alcohol reflux 4h that 2 times of weight concentrations are 75%, filtering is then cooled to, obtains
First filtrate；Add the water of 3 times of weight of filter residue, 2.5h kept at 80-90 DEG C of temperature, be then cooled to 30 DEG C, filtering, the
Two filtrates；Merging filtrate, is concentrated under reduced pressure, is freeze-dried, and low-temperature grinding is into the traditional Chinese medicine fine powder for being ground into 0.05-0.2mm；
(2) high speed shear, formation are carried out after the traditional Chinese medicine fine powder in step (1) is mixed with emulsifying agent, water with cutter
Grain particle diameter is less than 50 microns of Chinese medicine particulate；
(3) the Chinese medicine particulate in the functional oligose, maltodextrin and step (2) of predetermined weight number is uniformly mixed
Close, sterilized by heat exchanger, condition is 99 DEG C, 300s；
(4) mixture is cooled to 40-45 DEG C after sterilizing, and the probiotics for adding scheduled volume is freeze-dried, is added after being well mixed
Dry granulating machine is granulated, and the fermentation composition of powdery is made, and sterile packing is produced.
The fermentation composition of embodiment 2
The prescription of the fermentation composition of the present embodiment is：
Functional oligose：Oligoisomaltose 100g, chitosan 0.5g, xylo-oligosaccharide 1g；
Probiotics powder agent：20.03g, wherein containing 6 parts of Bifidobacterium, 2.2 parts of Lactobacillus rhamnosus in per g probiotic powders, doing
1.2 parts of Lactobacillus paracasei, 1.4 parts of lactobacillus acidophilus, 3 parts of Lactobacillus plantarum；
Traditional Chinese medicine ingredients：10.02g, is formed wherein being extracted per g Chinese medical extracts by the raw material of following portions by weight：Matrimony vine 1.2
1.3 parts of part, 1.5 parts of mulberries, 1.1 parts of sea-buckthorn, 1.5 parts of the root of kudzu vine, 1.2 parts of the stem of noble dendrobium and cassia seed；
Preparation method：
(1) preparation of Chinese medical extract：
The root of kudzu vine and cassia seed of the parts by weight are crushed respectively, 60 mesh sieves are crossed, root of kudzu vine powder and Cassia Seed is made；
By root of kudzu vine powder, the matrimony vine of Cassia Seed and predetermined weight part, mulberries, sea-buckthorn, 8 times of weight of the stem of noble dendrobium water,
4h is kept at 80-90 DEG C of temperature, 40 DEG C, plus the alcohol reflux 4h that 2 times of weight concentrations are 75%, filtering is then cooled to, obtains
First filtrate；Add the water of 3 times of weight of filter residue, 2.5h kept at 80-90 DEG C of temperature, be then cooled to 30 DEG C, filtering, the
Two filtrates；Merging filtrate, is concentrated under reduced pressure, is freeze-dried, and low-temperature grinding is into the traditional Chinese medicine fine powder for being ground into 0.05-0.2mm；
(2) high speed shear, formation are carried out after the traditional Chinese medicine fine powder in step (1) is mixed with emulsifying agent, water with cutter
Grain particle diameter is less than 50 microns of Chinese medicine particulate；
(3) the Chinese medicine particulate in the functional oligose of predetermined weight number and step (2) is uniformly mixed, passes through heat exchange
Device is sterilized, and condition is 99 DEG C, 300s；
(4) mixture is cooled to 40-45 DEG C after sterilizing, and the probiotics for adding scheduled volume is freeze-dried, is added after being well mixed
Dry granulating machine is granulated, and the fermentation composition of powdery is made, and sterile packing is produced.
The fermentation composition of embodiment 3
The prescription of the fermentation composition of the present embodiment is：
Functional oligose：Oligoisomaltose 60g, chitosan 0.2g, xylo-oligosaccharide 0.8g；
Probiotics powder agent：2.03g, wherein in per g probiotic powders containing 4.4 parts of Bifidobacterium, 2.3 parts of Lactobacillus rhamnosus,
1.4 parts of Lactobacillus casei, 1.6 parts of lactobacillus acidophilus, 2.6 parts of Lactobacillus plantarum；
Traditional Chinese medicine ingredients：0.203g, is formed wherein being extracted per g Chinese medical extracts by the raw material of following portions by weight：Matrimony vine 2
3 parts of part, 3 parts of mulberries, 1.6 parts of sea-buckthorn, 3 parts of the root of kudzu vine, 2 parts of the stem of noble dendrobium and cassia seed；
Maltodextrin 609g
Preparation method：Prepared according to the preparation method of embodiment 1, pulvis, every bag of 30g is made.
The fermentation composition of embodiment 4
The prescription of the fermentation composition of the present embodiment is：
Functional oligose：Oligoisomaltose 81g, chitosan 0.2g, xylo-oligosaccharide 0.9g；
Probiotics powder agent：18.66g, wherein in per g probiotic powders containing 5.5 parts of Bifidobacterium, 2.4 parts of Lactobacillus rhamnosus,
1.3 parts of Lactobacillus casei, 1.7 parts of lactobacillus acidophilus, 2.4 parts of Lactobacillus plantarum；
Traditional Chinese medicine ingredients：37.3g, is formed wherein being extracted per g Chinese medical extracts by the raw material of following portions by weight：Matrimony vine 0.3
0.5 part of part, 0.5 part of mulberries, 0.1 part of sea-buckthorn, 0.5 part of the root of kudzu vine, 0.3 part of the stem of noble dendrobium and cassia seed；
Preparation method：Prepared according to the preparation method of embodiment 2, pulvis, every bag of 30g is made.
The fermentation composition of embodiment 5
The prescription of the fermentation composition of the present embodiment is：
Functional oligose：Xylo-oligosaccharide 43g soy oligosaccharides Icing Sugar 11g FOSs 8g
Probiotics powder agent：15.5g, wherein containing 4 parts of bifidobacterium longum, 1.8 parts of Lactobacillus casei, saliva in per g probiotic powders
2.2 parts of 0.9 part of liquid lactobacillus, 1.5 parts of lactobacillus acidophilus and Lactobacillus plantarum；
Traditional Chinese medicine ingredients：38.75g；Extracted and formed by the raw material of following portions by weight wherein per g Chinese medical extracts：Matrimony vine 1.2
Part, 2.1 parts of mulberries, 1.3 parts of sea-buckthorn, 2.1 parts of the root of kudzu vine, 0.9 part of the stem of noble dendrobium, 1.8 parts of cassia seed；
Maltodextrin 155g
Preparation method：Prepared according to the preparation method of embodiment 1, pulvis, every bag of 30g is made.
The fermentation composition of embodiment 6
The prescription of the fermentation composition of the present embodiment is：
Functional oligose：Kanjak mannan-oligosaccharides 53g, mannan-oligosaccharides 23g, trehalose 15g；Probiotics powder agent：
10.1g, wherein containing 2.3 parts of bifidobacterium breve, 2 parts of bifidobacterium lactis, 2.4 parts of Lactobacillus rhamnosus, Switzerland in per g probiotic powders
9 parts of 1.3 parts of lactobacillus, 1 part of Bu Shi lactobacillus, 1.7 parts of lactobacillus bulgaricus and lactobacillus paracasei；
Traditional Chinese medicine ingredients：4.55g；Extracted and formed by the raw material of following portions by weight wherein per g Chinese medical extracts：Matrimony vine 1.4
Part, 2.6 parts of mulberries, 0.5 part of sea-buckthorn, 1.6 parts of the root of kudzu vine, 0.8 part of the stem of noble dendrobium and cassia seed 2.1g；
Maltodextrin 111g
Preparation method：Prepared according to the preparation method of embodiment 1, pulvis, every bag of 30g is made.
The fermentation composition of embodiment 7
The prescription of the fermentation composition of the present embodiment is：
The pulvis fermentation composition 24g that embodiment 1 is made；Acetobacter 1g；Lactic acid bacteria 1g；Coating solution is by acroleic acid resin
II 20g, diethyl phthalate 2.5g and the appropriate purifying of castor oil 0.5g additions are prepared；
Preparation method：
(1) softwood is made in the pulvis fermentation composition of 1/2 amount, after being well mixed with the lactic acid bacteria of the parts by weight
Carry out extrusion and make ball, capsule core is made；
(2) the pulvis fermentation composition of 1/2 amount is well mixed with the acetobacter of the parts by weight, softwood is made
Thing, it is standby；
(3) obtained capsule core is placed in the coating solution prepared in advance, be coated；
(4) the round as a ball extruding in the softwood thing of step (2) to the coating capsule core after Cotton seeds, then be dried, produce
Pellet fermentation composition, packaging.
Wherein obtained pellet diameters are 4-7mm, a diameter of 2-5mm of capsule core；It is preferred that pellet diameters 5mm, capsule core is a diameter of
2.8mm。
The fermentation composition of embodiment 8
The pulvis fermentation composition 33.11g that embodiment 3 is made；Acetobacter 5g；Lactic acid bacteria 5g；Coating solution is by acrylic acid
The appropriate purifying of resin II 20g, diethyl phthalate 2g addition is prepared；Preparation method：
(1) softwood is made in the pulvis fermentation composition of 1/2 amount, after being well mixed with the lactic acid bacteria of the parts by weight
Carry out extrusion and make ball, capsule core is made；
(2) the pulvis fermentation composition of 1/2 amount is well mixed with the acetobacter of the parts by weight, softwood is made
Thing, it is standby；
(3) obtained capsule core is placed in the coating solution prepared in advance, be coated；
(4) the round as a ball extruding in the softwood thing of step (2) to the coating capsule core after Cotton seeds, then be dried, produce
Pellet fermentation composition, packaging.
Wherein obtained pellet diameters are 4-7mm, a diameter of 2-5mm of capsule core；It is preferred that pellet diameters 5mm, capsule core is a diameter of
2.8mm。
The plant enzyme of embodiment 9
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition:Prepared according to the fermentation composition of embodiment 1；
B) preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight adds into plant material
Enter 10L pure water, be well mixed, stand after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extraction liquid；
C) preparation of plant enzyme stoste：Composite flora is inoculated with into plant extraction liquid, mixing is placed in closed environment, carried out
Lucifuge is fermented 2 months, obtains plant enzyme stoste；
Wherein inoculum concentration is 12%；Composite flora is Lactobacillus plantarum, gram lactobacillus, lactobacillus acidophilus and acetic acid
In bacillus；
D) preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L
Water and plant material 1kg, add fermentation composition prepared by 150ml plant enzyme stoste and 30g step a), in closed
Fermented in environment, fermentation temperature is 28~30 DEG C, is deflated 1~2 time daily, after fermentation 6d, filtering produces plant enzyme.
Wherein, plant material selects apple 500g, guava soybean g and tomato 300g, and clean section is used.
Organoleptic parameters：The plant enzyme uniform color, in bronzing, has strong fruity and the fragrance that ferments, mellow in taste,
Comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
The plant enzyme of embodiment 10
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition：Prepared according to the fermentation composition of embodiment 2；
B) preparation of plant extraction liquid：1kg plant material is cleaned, the sugared to plant material of 0.3~0.6kg weight is added
In, and 5~6L pure water is added, it is well mixed, stands after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extract
Liquid；
C) mixing and initial fermentation：Add plant of fermentation composition of the weight for 60g step a) preparations into step b)
In thing extract solution, mixing is placed in closed environment, keeps 28 DEG C of fermentation temperature, carries out lucifuge fermentation, obtains initial fermentation liquid；
D) zymotic fluid carries out after-ripening 7d in closed environment, filtering, produces plant enzyme.
Wherein, plant material selects Kiwi berry 100g, strawberry 90g, hawthorn 40g, mango 220g, carrot 80g, ternip
140g, Chinese cabbage 150g, agaric 80g and mushroom 100g.
Organoleptic parameters：The plant enzyme uniform color, between buff and brown, having, strong fruity and fermentation are fragrant
Gas, mellow in taste, comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
The plant enzyme of embodiment 11
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition：Prepared according to the fermentation composition of embodiment 3；
B) preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight adds into plant material
Enter 10L pure water, be well mixed, stand after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extraction liquid；
C) preparation of plant enzyme stoste：Composite flora is inoculated with into plant extraction liquid, mixing is placed in closed environment, carried out
Lucifuge is fermented 1 month, obtains plant enzyme stoste；
Wherein inoculum concentration is 8~12%；Composite flora is saccharomyces cerevisiae, the newborn subspecies of Lactobacillus delbrueckii, Lactobacillus plantarum, leather
It is several in Lan Shi lactobacillus, lactobacillus acidophilus and acetobacter；
D) preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L
Water and plant material 1kg, add fermentation composition prepared by 150ml plant enzyme stoste and 30g step a), in closed
Fermented in environment, fermentation temperature is 28~30 DEG C, is deflated 1~2 time daily, after fermentation 4d, filtering produces plant enzyme.
Wherein, plant material selects passion fruit 120g, citrus 200g, grape 100g, Chinese yam 50g, pumpkin 220g, celery
40g, water spinach 50g, bean sprouts 50g, sea-tangle 60g, seaweed 40g and asparagus 70g.
Organoleptic parameters：The plant enzyme uniform color, in dark brown, has strong fruity and the fragrance that ferments, mellow in taste,
Comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
The plant enzyme of embodiment 12
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition：Prepared according to the fermentation composition of embodiment 6；
B) preparation of plant extraction liquid：1kg plant material is cleaned, the sugared to plant material of 0.3~0.6kg weight is added
In, and 5~6L pure water is added, it is well mixed, stands after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extract
Liquid；
C) mixing and initial fermentation：The fermentation composition for the step a) preparations that weight is 30~60g is added into step b)
Plant extraction liquid in, mixing is placed in closed environment, keeps 30 DEG C of fermentation temperature, carries out lucifuge fermentation, obtains initial fermentation liquid；
D) zymotic fluid carries out after-ripening 7d in closed environment, filtering, produces plant enzyme.
Wherein, plant material selects apple 500g, soybean 200g and tomato 300g.
Organoleptic parameters：The plant enzyme uniform color, in bronzing, has strong fruity and the fragrance that ferments, mellow in taste,
Comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
The plant enzyme of embodiment 13
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition：Prepared according to the fermentation composition of embodiment 1；
B) mixed material：1kg plant material is cleaned, is put into the sugar of 0.3~0.6kg weight in ferment bucket, addition 5~
6L pure water, is well mixed, while add in fermentation composition to the ferment bucket that weight is prepared for 20~50g step a),
Capping, lucifuge fermentation is carried out in fermentation temperature is 28~30 DEG C of environment；
C) ferment：Fermentate in ferment bucket is carried out after stirring sooner or later once daily, 4~6d of fermentation, filtering is produced
Plant enzyme.
Wherein, plant material selects apple 500g, soybean 200g and tomato 300g.
Organoleptic parameters：The plant enzyme uniform color, in bronzing, has strong fruity and the fragrance that ferments, mellow in taste,
Comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
The plant enzyme of embodiment 14
The plant enzyme of the present embodiment is prepared from by following methods：
I the fermentation composition of pellet) is prepared according to embodiment 7
II) the preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of 1kg weight is added into plant material, and
10L pure water is added, is well mixed, is stood after 1~2d of extraction, high-temperature sterilization is carried out, filtering obtains plant extraction liquid；
III) the preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g,
8L water and plant extraction liquid 1kg, add 30g step II) prepare pellet fermentation composition, in closed environment carry out
Fermentation；Fermentation temperature is 30~32 DEG C, is deflated 1~2 time daily；Ferment after 1~2d, insertion conduit is passed through air, daily ventilation
2-4 times, each 10-30min, and control fermentation temperature to be 35~37 DEG C；Filtered after 5~7d of fermentation, produce plant enzyme.
Wherein, plant material selects apple 500g, soybean 200g and tomato 300g.
Organoleptic parameters：The plant enzyme uniform color, in bronzing, has strong fruity and the fragrance that ferments, mellow in taste,
Comfortable acid, entrance is not stimulated, and pleasant impression is sweet.
Observation to the pellet fermentation composition fermentation process of embodiment 7：Pellet fermentation composition during the fermentation, ball
The outer layer component of grain dissolves rapidly in the solution, and subsequent capsule core dissolving is slow, and coating membrane fades away after about 1-2d, and capsule core is completely molten
Solution.
The fermentation composition of comparative examples 1
The prescription of the fermentation composition of the present embodiment is：：
Functional oligose：Oligoisomaltose 80g chitosan 0.15g xylo-oligosaccharides 0.6g
Probiotics powder agent：8.075g, wherein containing 4.5 parts of Bifidobacterium, 2 parts of Lactobacillus rhamnosus in per g probiotic powders, doing
1.6 parts of Lactobacillus paracasei, 1.8 parts of lactobacillus acidophilus, 2.3 parts of Lactobacillus plantarum；
Maltodextrin 80.75g.
Preparation method：
(1) functional oligose of predetermined weight number, maltodextrin are uniformly mixed, sterilized by heat exchanger,
Condition is 99 DEG C, 300s；
(2) mixture is cooled to 40-45 DEG C after sterilizing, and the probiotics for adding scheduled volume is freeze-dried, is added after being well mixed
Dry granulating machine is granulated, and the fermentation composition of powdery, sterile pack, every bag of 30g is made.
The plant enzyme of comparative examples 2
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of fermentation composition：Prepared by the fermentation composition of comparative examples 1；
B) preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight adds into plant material
Enter 10L pure water, be well mixed, stand after extraction 2d, carry out high-temperature sterilization, filtering obtains plant extraction liquid；
C) preparation of plant enzyme stoste：Composite flora is inoculated with into plant extraction liquid, mixing is placed in closed environment, carried out
Lucifuge is fermented 1~2 month, obtains plant enzyme stoste；
Wherein inoculum concentration is 12%；Composite flora is Lactobacillus plantarum, gram lactobacillus, lactobacillus acidophilus and acetic acid
In bacillus；
D) preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L
Water and plant material 1kg, add fermentation composition prepared by 150ml plant enzyme stoste and 30g step a), in closed
Fermented in environment, fermentation temperature is 28~30 DEG C, is deflated 1~2 time daily, after fermentation 6d, filtering produces plant enzyme.
Wherein, plant material selects apple 500g, soybean 200g and tomato 300g.
The plant enzyme of comparative examples 3
The plant enzyme of the present embodiment is prepared from by following methods：
A) preparation of plant extraction liquid：1kg plant material is cleaned, the sugared to plant material of 0.3~0.6kg weight is added
In, and 5~6L pure water is added, it is well mixed, stands after 1~2d of extraction, carry out high-temperature sterilization, filtering obtains plant extract
Liquid；
B) mixing and initial fermentation：It is inoculated with plant extraction liquid of the compound probiotic into step b), mixing is placed in closed
Environment, keeps 30 DEG C of fermentation temperature, carries out lucifuge fermentation, obtains initial fermentation liquid；
C) zymotic fluid carries out after-ripening 7d in closed environment, takes Partial fermentation liquid to filter, does organoleptic parameters；Continue after-ripening
14d, takes Partial fermentation liquid to filter, does organoleptic parameters.
Wherein, compound probiotic be Bifidobacterium, Lactobacillus rhamnosus, Lactobacillus casei,
Lactobacillus acidophilus and Lactobacillus plantarum；Inoculum concentration is 8% (mass percent)；
Plant material selects apple 500g, soybean 200g and tomato 300g.
The organoleptic parameters of zymotic fluid after 7 days：The plant enzyme color and luster is in bronzing, and tissue mobility is big, entrance slightly has
Stimulation, sweet taste are heavier；The organoleptic parameters of zymotic fluid after 14 days：The plant enzyme uniform color, in bronzing, there is strong
Fruity is not stimulated with fermentation fragrance, mellow in taste, comfortable acid, entrance, and pleasant impression is sweet.Understand, plant prepared by conventional method
Fermentation time of the fermentation time than embodiment 9-11 that ferment needs is longer.
Oligosaccharide content detection in the plant enzyme of test example 1
1st, instrument
Using Japanese Shimadzu LC-4A high performance liquid chromatographs, PID-2AS differential refraction detectors, WatersTCM post constant temperature
Case, WATERS745 integrators.
2nd, chromatography experiment condition
(1) column temperature：Selected column temperature is 40 DEG C and is used as experimental condition.
(2) mobile phase：It is fine using second：The ratio of water is respectively 65：35；70：30；75：25 and 80:：20 4 kinds combine into
Row experimental study.Sucrose, gossypose, the retention time of stachyose are respectively 7.14,11.05,17.45 points, whole separation determination
Process can be completed within the time of 20 minutes.
(3) chromatographic condition：Chromatographic column：Waters Spherisorb 5μmNH24.6×250mm；Column temperature:40℃；Flowing
Phase：Second is fine：Water is 7：3；Flow velocity：1ml/min；Differential refraction detector；Range is 0.5.
3rd, the processing of test sample
The ferment solution of embodiment 9 is dissolved with 4 parts of alcohol constant volumes and fully shaking, filtrate passes through 0.45 after filter paper filtering
μm organic membrane filtration after upper machine determine.
(2) after sample being dissolved with 3 parts of water, dissolved with 7 parts of fine constant volumes of second and fully shaking, filtrate passes through after filter paper filtering
Upper machine is determined after 0.45 μm of organic membrane filtration.
4th, result and analysis
The measure of 4.1 standard curves
(1) preparation of standard liquid:0.2500g gossyposes and stachyose are accurately weighed respectively, are settled to water dissolving
10ml, concentration is 20mg/ml storing solution；Then be configured to concentration be respectively 2.5,5.0,7.5,10.0,15.0mg/ml makes
Use liquid.Glucose, fructose, sucrose are configured to 2mg/ml standard liquid respectively, qualitative for being carried out to these three sugar.
(2) draw respectively and use liquid 10ul, the chromatographic condition in 2.2 (3) determines peak height.As a result show, gossypose is returned
Equation is y=-0.2566+0.1204x, and coefficient correlation is r=0.9591；Stachyose is y=0.0996+0.1314x, phase relation
Number is r=0.9844.It is proportionate between concentration and peak height, correlation is good, is quantitative determined available for external standard method.
The measure of 4.2 samples
(1) it is put into after 150ml samples are dissolved with 40ml85% ethanol in ultrasonic wave and vibrates 10min, is used after taking-up
85% ethanol is transferred to constant volume in 50ml volumetric flasks, is filtered after mixing with filter paper, and filtrate is surveyed by upper machine after 0.45 μm of filter membrane
It is fixed.
(2) it is fine for second through the selected mobile phase of experiment：Water (7：3), glucose can not be had with fructose on this condition
Effect separation, retention time is all 6.04, but sucrose and raffinose, stachyose good separating effect, its retention time is respectively 7.54,
11.32 and 18.09min.
Measurement result is shown in Table 1：
Raffinose and stachyose measurement result (unit in the plant enzyme of table 1：mg/100ml)
As a result show, the plant macromolecular sugar in plant enzyme has been converted into small molecule oligosaccharide, and high conversion rate；Wood
Sugar and raffinose can turn into the foodstuff of enteral beneficial bacterium Bifidobacterium Bifidum, can fast breeding Bifidobacterium Bifidum, effectively suppress harmful
Bacterium breeds, and promotes intestines peristalsis, thus, it is possible to prevent a large amount of generations of harmful substance in enteron aisle, mitigates burden of liver, so as to rise
To preventing and treat the effect of " three high ".
The viable bacteria survival detection of the fermentation composition of test example 2
Fermentation composition prepared by the embodiment of the present invention 1 and embodiment 7, be prepared into sterilized water viable count for 2 ×
108CFU/mL solution to be measured, is saved backup in 4 DEG C；
The 10mL kept the solution to be measured of going bail for is injected into test tube 1, and 10 are diluted to step by step using ten times-8, take 1mL to dilute
The MRS agar mediums that 45 DEG C are cooled to after sterilizing are poured on flat board (sterilizing), shaken up rapidly on flat board by liquid.Again will
The test tube 2 of solution to be measured equipped with 10mL, which is placed in 80-90 DEG C of water-bath, heats 15-25min, takes the solution to be measured after heating to enter
Row ten is diluted to 10 step by step again-8, 1mL dilutions are taken on flat board, and the MRS agar mediums that 45 DEG C are cooled to after sterilizing are poured into
Shake up on flat board (sterilizing) and rapidly.Flat board before finally heating and after heating cultivates 24h under the conditions of 35 DEG C, calculates
Number of viable before and after heating.
As a result show, Viable detection is respectively 89% and 87%.
The viable bacteria survival detection of the plant enzyme of test example 3
1st, simulate the gastric juice and the resistance test of intestinal juice
100g/L hydrochloric acid 16.4mL plus distilled water diluting is taken, it is respectively 1.5,2.5 and 3.5 to make pH value, take the dilute salt of 100mL
Acid solution, is separately added into 1g pepsins, it is fully dissolved, and obtains simulate the gastric juice, and miillpore filter degerming (0.22 μm) is standby.Take
Potassium dihydrogen phosphate 6.8g, the 500mL that adds water makes dissolving, and pH value is adjusted to 6.8 with 0.1moL/L sodium hydroxide solutions；Separately take tryptose
Enzyme 10g, the 100mL that adds water makes dissolving, after two liquid are mixed, is diluted with water to 1000ml, obtains simulated intestinal fluid, miillpore filter is degerming
(0.22 μm) is standby.
The plant enzyme solution of embodiment 9 that 1mL is kept and embodiment 14 is taken to be added in 9mL simulate the gastric juice respectively
(i.e. ten times dilute step by step), and rapid fully mixing on the oscillator, are subsequently placed in 30-45 DEG C of quiescent culture 2-4h.Exist respectively
Nutrient solution is taken out when 1h, 2h, 3h, 4h and remaining viable count is counted immediately, is compared, as a result shows with former viable count,
Viable detection is respectively 96% and 98%.Then each 1mL of nutrient solution that different time is digested in simulated gastric fluid is taken, is connect respectively
Plant in 9mL pH value in 6.8 simulated intestinal fluid, to be placed in 30-45 DEG C of quiescent culture 2-4h, and sampled respectively in 0,3,6,24h,
Its viable count is determined, is compared with former viable count, as a result shows that Viable detection reaches 99% respectively.
The plant enzyme reducing blood lipid of test example 4
Foundation《Health food is examined and assessment technique specification》Auxiliary hyperglycemic, hypolipemic function human trial evaluation method
It is prepared by embodiment 9, embodiment 11, embodiment 12, embodiment 13, embodiment 14, comparative examples 2 and comparative examples 3
The plant enzyme of acquisition carries out the evaluation of clinical experience side, specific as follows：
1st, evaluation method：
Select 44 type II diabetes people, the wherein people of male 21, the people of women 23, the range of age 38-75 Sui, without serious conscience
The complication such as kidney, rear contrast design in taking before test-meal.
Subject is randomly divided into 4 groups, every group of 11 people, subject's original diet control and activity are constant, and packet situation is：
Group 1：The plant enzyme of edible embodiment 9；
Group 2：The plant enzyme of edible embodiment 13；
Group 3：The plant enzyme of edible embodiment 14；
Group 4：The plant enzyme of edible comparative examples 2；
It is taken twice daily, each 60ml takes after being diluted with warm water.
Patient's blood pressure, stool and urine, the change of body weight are monitored, and the blood glucose determined on an empty stomach with 2 hours after the meal (uses grape glycosyloxy
Chemical-enzyme method)；Determine blood fat (T-CHOL TC, triglycerides TG and HDL HDL-C).
2nd, effect criterion：
It is effective：Cardinal symptom disappears, and declines on an empty stomach and before the relatively treatment of the blood glucose of 2 hours after the meal and is no more than 30%；TC is reduced
＞ 20%；TG reduces ＞ 30%；HDL-C rises ＞ 0.208mmol/L.
Effectively：Cardinal symptom is obviously improved, and declines on an empty stomach and before the blood glucose of 2 hours is relatively treated after the meal no more than 10%；TC
Reduce ＞ 10%；TG reduces ＞ 15%；HDL-C rises ＞ 0.104mmol/L；
It is invalid：Cardinal symptom is not improved, and the blood glucose of 2 hours is dropped by less than 10% before relatively treating on an empty stomach and after the meal；Blood
Fat standard is not up to effective standard person.
3rd, evaluation result：
Compared with before test-meal, after test-meal 30 days, the blood pressure of the patient of each group ferment, stool and urine, body weight are taken without aobvious
Sex differernce is write, but fasting blood-glucose, after the meal 2 hours blood glucoses have obvious reduction, and concrete outcome is shown in Table 2.
The blood glucose test results of the test-meal sufferer of table 2
From the above results, the plant enzyme blood sugar decreasing effect of group 1, group 2 and group 3 is more notable, and group 3 is optimal；4 nothings of group
The plant enzyme effect for adding the preparation of traditional Chinese medicine ingredients fermentation composition is worst.
Compared with before test-meal, after test-meal 30 days, before taking the cholesterol of the patient of each group ferment, triglycerides compared with test-meal
There is obvious reduction, HDL is compared with there is obvious rise before test-meal, concrete outcome is shown in Table 3.
The lipids detection result of the test-meal sufferer of table 3
From the above results, the plant enzyme lipid-lowering effect of group 1, group 2 and group 3 is more notable, and group 3 is optimal；4 nothings of group
The plant enzyme effect for adding the preparation of traditional Chinese medicine ingredients fermentation composition is worst.
The plant enzyme hypotensive of test example 5
1st, evaluation method：
Ferment of the present invention is taken according to 40 patients for being diagnosed as hypertension, the curative effect to plant enzyme of the present invention is seen
Examine evaluation.
Diagnostic criteria：Systolic pressure is equal to or higher than 160mmHg, and diastolic pressure is equal to or higher than 95mmHg, and both have a warp
Examine, you can make a definite diagnosis.
Subject is randomly divided into 4 groups, every group of 10 people, packet situation is：
Group 1：The plant enzyme of edible embodiment 9；
Group 2：The plant enzyme of edible embodiment 13；
Group 3：The plant enzyme of edible embodiment 14；
Group 4：The plant enzyme of edible comparative examples 2；
It is taken twice daily, each 60ml, is taken after being diluted with warm water 30 days.Diet and amount of exercise between experimental period
With being consistent before experiment, indices in test-meal test start and at the end of each test once.
2nd, effect criterion：
It is effective：More than diastole drops 10mmHg, and reach normal range (NR)；Though diastolic pressure is not near normal, decline
20mmHg or more, need to possess one of which；
Effectively：Diastole drops are not as good as 10mmHg, but to reach normal range (NR)；The preceding decline 10 of diastolic pressure relatively treatment~
19mmHg, but not up to normal range (NR)；Systolic pressure declines 30mmHg before relatively treating, and need to possess one of which；
It is invalid：Not up to above standard.
3rd, evaluation result
Each group case treatment comparitive study the results are shown in Table 4.
Blood pressure measurement before and after the test-meal of table 4
From the above results, group 1, group 2, the plant enzyme blood pressure lowering effect of group 3 are shown as significantly, and best results are
Group 3；And the plant enzyme effect for organizing 4 no added traditional Chinese medicine ingredients fermentation compositions preparations is worst；.
Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that：Not
In the case of departing from the principle and objective of the present invention a variety of change, modification, replacement and modification can be carried out to these embodiments, this
The scope of invention is limited by claim and its equivalent.
Claims (10)
1. a kind of prepare the fermentation group with prevention conditioning hypertension, high fat of blood, hyperglycaemia and routine servicing effect plant enzyme
Compound, it is characterised in that the fermentation composition is direct putting type plant enzyme fermenting agent, the fermentation composition includes following weight
Measure the component of number：0.01~10 part of 3~22 parts of functional oligose, 0.1~5 part of probiotics and Chinese medical extract,
Wherein, the probiotics is one or more of jellies in Bifidobacterium, lactobacillus and streptococcus thermophilus
Dry powder；
Every part of Chinese medical extract is extracted by the raw material of following parts by weight and formed：0.3~2 part of matrimony vine, 0.5~3 part of mulberry
Shen, 0.1~1.6 part of sea-buckthorn, 0.5~3 part of the root of kudzu vine, 0.3~2 part of the stem of noble dendrobium and 0.5~3 part of cassia seed；
The preparation method of the fermentation composition at least comprises the steps：
The fine powder that the functional oligose and Chinese medical extract of predetermined weight number are made is sterilized after mixing, after sterilization with it is prebiotic
Bacteria powder is uniformly mixed, granulation, and the fermentation composition of powdery is made.
2. fermentation composition as claimed in claim 1, it is characterised in that the fermentation composition is 5~10 by parts by weight
The functional oligose, 1~3 part of probiotics and 0.5~1 part of Chinese medical extract composition of part；
Every part of Chinese medical extract is extracted by the raw material of following parts by weight and formed：0.9~1.2 part of matrimony vine, 1.2~1.5 parts
Mulberries, 0.6~1.1 part of sea-buckthorn, 1.2~1.5 parts of the root of kudzu vine, 0.9~1.2 part of the stem of noble dendrobium and 1~1.3 part of Cassia
Son.
3. fermentation composition as claimed in claim 1, it is characterised in that the functional oligose is selected from chitosan, low
Xylan, kanjak mannan-oligosaccharides, mannan-oligosaccharides, milk ketose, raffinose, soyabean oligosaccharides, FOS, oligomeric gala
One or more in sugar, lactosucrose, konjac mannan sugar, trehalose, palatinose and inulin；
The Bifidobacterium includes one kind in bifidobacterium longum, bifidobacterium breve, bifidobacterium infantis and bifidobacterium lactis
Or it is several；
The lactobacillus include Lactobacillus rhamnosus, Lactobacillus casei, lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus salivarius,
Lactobacillus helveticus, Bu Shi lactobacillus, lactobacillus bulgaricus, lactobacillus paracasei and one kind or several in lactobacillus reuteri
Kind.
4. fermentation composition as claimed in claim 1, it is characterised in that it is 10 that the fermentation composition, which also includes parts by weight,
~30 parts of maltodextrin.
5. fermentation composition as claimed in claim 4, it is characterised in that the functional oligose is 8-10 by parts by weight
The oligoisomaltose, 0.015-0.05 parts of chitosan and 0.06-0.1 parts of xylo-oligosaccharide composition of part；
The probiotics is probiotics powder agent, is uniformly mixed by the pulvis of following parts by weight：45~60 parts of Bifidobacterium,
20~25 parts of Lactobacillus rhamnosus, 12~16 parts of Lactobacillus casei, 14~18 parts of lactobacillus acidophilus and Lactobacillus plantarum 23~
30 parts, the viable bacteria content of the probiotics powder agent is 2 × 108~8 × 108cfu/g。
6. such as fermentation composition according to any one of claims 1 to 5, it is characterised in that the fermentation composition also includes
Acetobacter and 1~5 part of lactic acid bacteria of the parts by weight for 1~5 part；
The preparation method of the fermentation composition also includes：
(1) softwood is made in the fermentation composition of the powdery of 1/2 amount, is well mixed with the lactic acid bacteria of the parts by weight laggard
Row extrusion makes ball, and capsule core is made；
(2) fermentation composition of the powdery of 1/2 amount is well mixed with the acetobacter of the parts by weight, softwood is made
Thing, it is standby；
(3) obtained capsule core is placed in the coating solution prepared in advance, be coated；
(4) the round as a ball extruding in the softwood thing of step (2) to the coating capsule core after Cotton seeds, then be dried, produce pellet
Fermentation composition；
Wherein, the coating solution is by the O-phthalic for the acroleic acid resin No. II, 0.05-1 parts that parts by weight are 0.4-10 parts
Diethyl phthalate and 0-5 parts of castor oil add the aqueous dispersion that appropriate purified water is configured to.
7. fermentation composition as claimed in claim 4, it is characterised in that the preparation method bag of the fermentation composition of the powdery
Include following steps：
1) preparation of Chinese medical extract：
The root of kudzu vine and cassia seed of the parts by weight are crushed respectively, 60 mesh sieves are crossed, root of kudzu vine powder and Cassia Seed is made；
By root of kudzu vine powder, the matrimony vine of Cassia Seed and predetermined weight part, mulberries, sea-buckthorn, 8 times of weight of the stem of noble dendrobium water, in temperature
4h is kept at 80-90 DEG C of degree, 40 DEG C, plus the alcohol reflux 4h that 2 times of weight concentrations are 75%, filtering is then cooled to, obtains first
Filtrate；Add the water of 3 times of weight of filter residue, 2.5h kept at 80-90 DEG C of temperature, be then cooled to 30 DEG C, filtering, the second filter
Liquid；Merging filtrate, is concentrated under reduced pressure, is freeze-dried, and low-temperature grinding is into the traditional Chinese medicine fine powder for being ground into 0.05-0.2mm；
2) by step 1) in traditional Chinese medicine fine powder mixed with emulsifying agent, water after carry out high speed shear with cutter, form grain diameter
Chinese medicine particulate less than 50 microns；
3) by the functional oligose, maltodextrin and step 2 of predetermined weight number) in Chinese medicine particulate uniformly mix, pass through
Heat exchanger is sterilized, and condition is 99 DEG C, 300s；
4) mixture is cooled to 40-45 DEG C after sterilizing, and the probiotics for adding scheduled volume is freeze-dried, and adding dry method after being well mixed makes
Grain machine granulation, is made the fermentation composition of powdery, sterile packing is produced.
8. there is prevention conditioning hypertension, high fat of blood, hyperglycaemia and routine servicing any one of a kind of claim 1-5
The preparation method of the plant enzyme of effect, it is characterised in that the preparation method comprises the following steps：
(a) powdery fermentation composition is prepared
(b) mixed material：1kg plant material is cleaned, is put into the sugar of 0.3~0.6kg weight in ferment bucket, adds 5~6L
Pure water, be well mixed, at the same add weight be 20~50g the step of (a) prepare fermentation composition to ferment bucket in, envelope
Lid, lucifuge fermentation is carried out in fermentation temperature is 28~30 DEG C of environment；
(c) ferment：Fermentate in ferment bucket is carried out after stirring sooner or later once daily, 5~8d of fermentation, filtering produces plant
Thing ferment.
9. there is prevention conditioning hypertension, high fat of blood, hyperglycaemia and routine servicing any one of a kind of claim 1-5
The preparation method of the plant enzyme of effect, it is characterised in that the preparation method comprises the following steps：
A) fermentation composition of powdery is prepared
B) preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight is added into plant material
10L pure water, is well mixed, and stands after 1~2d of extraction, carries out high-temperature sterilization, and filtering obtains plant extraction liquid；
C) preparation of plant enzyme stoste：Composite flora is inoculated with into plant extraction liquid, mixing is placed in closed environment, carries out lucifuge
Fermentation 1~2 month, obtains plant enzyme stoste；
Wherein inoculum concentration is 8~12%；Composite flora is saccharomyces cerevisiae, the newborn subspecies of Lactobacillus delbrueckii, Lactobacillus plantarum, gram
It is several in lactobacillus, lactobacillus acidophilus and acetobacter；
D) preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L water with
And plant material 1kg, fermentation composition prepared by 150ml plant enzyme stoste and 30g step a) is added, in closed environment
Middle to be fermented, fermentation temperature is 28~30 DEG C, is deflated 1~2 time daily, after 4~6d of fermentation, and filtering produces plant enzyme.
10. the plant with prevention conditioning hypertension, high fat of blood, hyperglycaemia and routine servicing effect described in a kind of claim 6
The preparation method of thing ferment, it is characterised in that the preparation method comprises the following steps：
I the fermentation composition of pellet) is prepared
II) the preparation of plant extraction liquid：3kg plant material is cleaned, the sugar of addition 1kg weight is added into plant material
10L pure water, is well mixed, and stands after 1~2d of extraction, carries out high-temperature sterilization, and filtering obtains plant extraction liquid；
III) the preparation of plant enzyme：From more than 10L drum, addition native malt sugar 125g, vitamine C sodium 5g, 8L water
And plant extraction liquid 1kg, add 30g step II) prepare pellet fermentation composition, sent out in closed environment
Ferment；Fermentation temperature is 30~32 DEG C, is deflated 1~2 time daily；Ferment after 1~2d, insertion conduit is passed through air, and ventilate 2-4 daily
It is secondary, each 10-30min, and control fermentation temperature to be 35~37 DEG C；Filtered after 5~7d of fermentation, produce plant enzyme.
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| CN115025132A (en) * | 2022-06-09 | 2022-09-09 | 康永波 | Synbiotic composition and preparation method and application thereof |
| CN115025132B (en) * | 2022-06-09 | 2024-01-30 | 康永波 | Synbiotic composition and preparation method and application thereof |
| CN118064335A (en) * | 2024-04-22 | 2024-05-24 | 晏龙国科(山东)微生物科技有限公司 | Probiotic bacteria and composition with function of relieving nonalcoholic fatty liver and application thereof |
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Application publication date: 20170721 |