CN106982994B - A kind of milk cow plant essential oil composition and preparation method thereof - Google Patents
A kind of milk cow plant essential oil composition and preparation method thereof Download PDFInfo
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- CN106982994B CN106982994B CN201710166082.0A CN201710166082A CN106982994B CN 106982994 B CN106982994 B CN 106982994B CN 201710166082 A CN201710166082 A CN 201710166082A CN 106982994 B CN106982994 B CN 106982994B
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- milk cow
- thymol
- carvacrol
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- 239000000203 mixture Substances 0.000 title claims abstract description 83
- 241000283690 Bos taurus Species 0.000 title claims abstract description 69
- 235000013336 milk Nutrition 0.000 title claims abstract description 66
- 239000008267 milk Substances 0.000 title claims abstract description 66
- 210000004080 milk Anatomy 0.000 title claims abstract description 66
- 239000000341 volatile oil Substances 0.000 title claims abstract description 52
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims abstract description 136
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims abstract description 92
- 210000004767 rumen Anatomy 0.000 claims abstract description 74
- 239000005844 Thymol Substances 0.000 claims abstract description 68
- 229960000790 thymol Drugs 0.000 claims abstract description 68
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 claims abstract description 60
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 claims abstract description 60
- 235000007746 carvacrol Nutrition 0.000 claims abstract description 60
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 claims abstract description 60
- 235000013985 cinnamic acid Nutrition 0.000 claims abstract description 48
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims abstract description 48
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims abstract description 47
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims abstract description 47
- 229930016911 cinnamic acid Natural products 0.000 claims abstract description 47
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims abstract description 46
- 239000005770 Eugenol Substances 0.000 claims abstract description 46
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims abstract description 46
- 229960002217 eugenol Drugs 0.000 claims abstract description 46
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- 239000002253 acid Substances 0.000 claims description 14
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- 125000001931 aliphatic group Chemical group 0.000 claims description 11
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- 239000000194 fatty acid Substances 0.000 claims description 10
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
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- 235000003441 saturated fatty acids Nutrition 0.000 claims description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 6
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- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 3
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- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 3
- 239000000661 sodium alginate Substances 0.000 claims description 3
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- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 claims description 2
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- AXMVYSVVTMKQSL-UHFFFAOYSA-N UNPD142122 Natural products OC1=CC=C(C=CC=O)C=C1O AXMVYSVVTMKQSL-UHFFFAOYSA-N 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
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- GAOZTHIDHYLHMS-KEOBGNEYSA-N monensin A Chemical group C([C@@](O1)(C)[C@H]2CC[C@@](O2)(CC)[C@H]2[C@H](C[C@@H](O2)[C@@H]2[C@H](C[C@@H](C)[C@](O)(CO)O2)C)C)C[C@@]21C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H](OC)[C@H](C)C(O)=O)O2 GAOZTHIDHYLHMS-KEOBGNEYSA-N 0.000 abstract description 6
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- 206010012735 Diarrhoea Diseases 0.000 abstract description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 63
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- 235000019260 propionic acid Nutrition 0.000 description 30
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 30
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- 238000000855 fermentation Methods 0.000 description 14
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Landscapes
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A kind of milk cow plant essential oil composition of present invention offer and preparation method thereof.Milk cow plant essential oil composition includes the component of following parts by weight：The mixture of 1-8 parts of eugenol, 1-15 parts of cinnamic acid and the carvacrol and Thymol that are handled through rumen bypass through sustained release processing, the carvacrol of the rumen bypass processing and the mixture of Thymol include 10-40 parts of 1-8 parts of carvacrol, 1-8 parts of Thymol and rumen bypass carrier.When preparation, carvacrol and Thymol are done into rumen bypass coating with rumen bypass with carrier, obtained product is uniformly mixed with eugenol and cinnamic acid, obtains milk cow plant essential oil composition.A kind of milk cow plant essential oil composition of present invention offer and preparation method thereof, it is mainly used for substituting Rumensin in cud, harmful bacteria is killed in suppression in milk cow enteron aisle simultaneously, promote beneficial bacterium proliferation, prevent diarrhea of dairy cow and constipation, somatic number is reduced, butterfat percnetage and protein ratio are improved while improving the output of milk.
Description
Technical field
The invention belongs to field of feed additive technology more particularly to a kind of milk cow plant essential oil composition and its preparations
Method.
Background technology
The use of antibiotic ionophore (Rumensin) can reduce energy caused by lumen fermentation and protein
Loss.However, drug-fast bacteria may be remained and generate in livestock products without by big well-established by adding antibiotic in feed.
In January, 2006, European Union has prohibited the use of antibiotic.China cannot clearly add antibiotic in milk cow forage.
Based on this, the begin one's study substitute of antibiotic of animal nutrition science man regulates and controls lumen fermentation, including yeast, organic
Acid, plant extracts (mainly plants essential oil) and probiotic.
Plants essential oil has extensive antibacterial activity, has inhibitory or killing effect for Gram-negative bacteria and positive bacteria.These
What substance had can promote lumen fermentation, some inhibition lumen fermentations, some inhibition methane to generate, and what is had can change volatility
The composition and nitrogen metabolism of aliphatic acid.Some are the study found that certain plants essential oil and its group branch change each volatile fatty acid
Ratio, effect is similar with coban (for example reducing proportion of acetic acid, increase propionic acid ratio), these are considered as addition plant essence
The Beneficial Effect of oil.
Thymol (C10H14O), it is also Thymol, is the isomer of carvacrol, to most of Gram-positives
Bacterium and Gram-negative bacteria have inhibiting effect, are the active constituents for studying a kind of more plants essential oil at present.Borchers
(1965) influence of the thymol to lumen fermentation is had studied in vitro method, adding the thymol of 1000mg/L reduces culture
The concentration of ammonia nitrogen improves the concentration of amino acid nitrogen, illustrates that it can inhibit deamination.Evans etc. (2000) reports,
Under the conditions of pure culture, thymol has an impact bargen's streptococcus and the energetic supersession for ruminating the crescent monad of beast.It can be dropped
The concentration of low methane and lactic acid, but the production of nutritive digestibility and general volatile aliphatic acid can be reduced by improving additive capacity
Amount.Addition 100-400mg/L thymols make the ratio of acetic acid and propionic acid increase.Sensitivity of the crescent monad to thymol
Property by force than bargen's streptococcus (main Lactic Acid Producing), so as to cause the accumulation of lactic acid in rumen fluid, causes rumen fluid ph to drop
It is low, it has a negative impact to lumen fermentation.And the purpose of regulating rumen is exactly the opposite, it should try hard to reduce the concentration of lactic acid.It answers
The growth of the stimulation meniscus monad, inhibits the growth of bargen's streptococcus.It is slow that cud can be added while adding thymol
Electuary (NaHCO3 etc.).Castillejos etc. (2006) in vitro study shows that the thymol of 50mg/L does not have lumen fermentation
It influences, but the dosage of 500mg/L reduces the concentration of general volatile aliphatic acid and ammoniacal nitrogen；Long-term continuous cultivation and fermentation system
Result of study shows that the optimal dose of thymol is 50-500mg/L.In addition, the effect of thymol is by daily ration and cud
The influence of pH value.In daily ration essence slightly than being 40: 60 (coarse fodder is alfalfa), under conditions of pH is 6.4, thymol improves
The ratio of acetic acid and propionic acid.In daily ration essence slightly than being 90: 10 (coarse fodder is stalk, and fine fodder is corn, barley and dregs of beans), pH is
Under the conditions of 5.5, thymol reduces the ratio of acetic acid and propionic acid.
Eugenol (C10H12O2) have extensive antibacterial activity, be cloves, cassia oil main active.Continuous culture
Fermentation system reduces the molar ratio of acetic acid and branched chain fatty acid studies have shown that adding 2.2mg/L, improves mole of propionic acid
Ratio.Eugenol can also influence the metabolism of nitrogen, improve the concentration of peptide and reduce the concentration of amino acid nitrogen, illustrate that it can be reduced
The activity of rumen fluid peptase.Busquet etc. (2006) is studies have shown that eugenol can regulate and control the fermentation of cud, the total volatilization of reduction
Property aliphatic acid and ammoniacal nitrogen concentration, the linear molar ratio for improving propionic acid, the influence to acetic acid and butyric acid is in quadratic effect.One
As for, suitable dosage can improve dietary digestibility of energy and the utilization ratio of nitrogen.There is data to suggest that in daily ration essence slightly than being 40
: under conditions of 60 (fine fodder is corn, barley and dregs of beans, and coarse fodder is alfalfa), eugenol reduces branched chain fatty acid and tumor
The concentration of gastric juice ammoniacal nitrogen, deamination are inhibited.Daily ration essence slightly than for 90: 10 (coarse fodder is stalk, fine fodder be corn,
Dregs of beans and barley) under the conditions of, eugenol reduces the concentration of general volatile aliphatic acid and the ratio of propionic acid, improves the ratio of acetic acid
The ratio of example and acetic acid/propionic acid.This fermentation pattern is unfavorable to beef cattle production, and is advantageous to lactating cow.
Cinnamic acid (C9H8O) has antibacterial activity, is the main active of cassia oil, accounts for 75% of extract or so.
Cardozo etc. (2005) reports that experiment uses dosage for the continuous culture system of 0.22mg/L rumen fluids, the results showed that, it is right
Nitrogen metabolism has regulating and controlling effect, inhibits the activity of peptase, but to volatile fatty acid almost without effect.Cassia oil and cinnamic acid
Additive capacity, which is 3000mg/L rumen fluids, reduces general volatile aliphatic acid and ammonia nitrogen concentration.To single volatile fatty acid ratio
Influence it is different, cassia oil improves the molar ratio of acetic acid, but is not influenced on the molar ratio of propionic acid and butyric acid,
Cinnamic acid improves the ratio of propionic acid, is not influenced on acetic acid and butyric acid.These results indicate that cinnamic acid is the main of cassia oil
Active constituent, the other compositions in cassia oil have interaction, the effect of cinnamic acid more ideal with cinnamic acid.Busquet etc.
(2005) every liter of rumen fluid is had studied using Dual-flow continuous culture fermentation system and adds 31.2,312mg cinnamic acids respectively to tumor
The influence of stomach fermentation.The result shows which reduce the molar ratio of acetic acid, the molar ratio of propionic acid and butyric acid is improved.Ferme
It is reported Deng (2004), cinnamic acid can reduce the quantity of melaninogenicus, and this bacterium has the function of deamination.Above experiment knot
Fruit and discussion are obtained based on milk cow under conditions of high coarse fodder daily ration.Cardozo etc. (2005) uses smart slightly ratio for 90: 10
The rumen fluid of beef cattle under the conditions of daily ration, the in vitro study effect of cassia oil and cinnamic acid.When pH is 7, can both improve
The ratio of acetic acid and propionic acid reduces the concentration of ammonia nitrogen, shows that nutrient utilization ratio reduces.Comparatively, when pH is 5.5,
Ammonia nitrogen concentration and the third ratio of second all reduce.
(2011) such as domestic scholars woods waves have studied cinnamon oil, origanum oil and its main component cinnamic acid, perfume (or spice) in vitro method
0,50,200,500 and 750mg/L, hair are added in the influence that celery phenol ferments to vitro Rumen and methane generates in zymotic fluid respectively
Existing general volatile fatty acid concentration is reduced with the increase of plants essential oil additive amount, and high dose (500,750mg/L) addition
When, entire fermentation process is significantly inhibited.
In conclusion addition cinnamic acid and eugenol have positive acting to function of rumen of cow, you can to improve in cud
Propionic acid yield reduces acetic acid/propionic acid ratio.And add thymol has negative role to function of rumen of cow, that is, reduces propionic acid production
Amount improves acetic acid/propionic acid ratio.
Han Xu (2013) on laying hen studies have shown that addition origanum oil after can reduce enteron aisle Escherichia coli, Salmonella
The quantity of bacterium improves enteron aisle lactic acid bacteria and bifidobacteria, improves the height of intestinal villi, reduce the depth of crypts, improves
The activity of enteron aisle amylase, trypsase and lipase, increases glucose transporters (SGLT1, GLUT2) and small peptide transhipment carries
The mrna expression amount of body (PePT1), and then improve laying hen enteron aisle digestion and absorption function, improve the quantity of small bowel lymphatics cell.Hao
Dan Dan (2014), further studies have shown that can improve the amount of CD4+ in spleen after addition origanum oil, reduces CD8+ on laying hen
Amount, improve CD4+/CD8+ ratios, the amount of IgG, IgA, IgM in chicken serum can be improved.The expression quantity of IL-2mRNA in spleen
It is significantly improved with the expression quantity of IL-4mRNA.Show that the immunity of body significantly enhances.
Invention content
In view of the problems of prior art, a kind of milk cow plant essential oil composition of present invention offer and its preparation side
Method is mainly used for substituting Rumensin in cud, while harmful bacteria is killed in suppression in milk cow enteron aisle, promotes beneficial bacterium proliferation, prevents
Diarrhea of dairy cow and constipation reduce somatic number, and butterfat percnetage and protein ratio are improved while improving the output of milk.
The technical solution that the present invention solves above-mentioned technical problem is as follows：
The present invention provides a kind of milk cow plant essential oil composition, includes the component of following parts by weight：1-8 parts of eugenol,
The mixture of 1-15 parts of cinnamic acid and the carvacrol and Thymol that are handled through rumen bypass, the carvacrol of the rumen bypass processing
Mixture with Thymol includes 10-40 parts of 1-8 parts of carvacrol, 1-8 parts of Thymol and rumen bypass carrier.
The beneficial effects of the invention are as follows：
Cinnamic acid and eugenol have positive acting to ruminant tumor gastric function, you can to improve propionic acid yield in cud,
Acetic acid/propionic acid ratio is reduced, inhibits peptidase activity to reduce the concentration of ammoniacal nitrogen, improves the production performance of ruminant.And thyme
Phenol and carvacrol have negative role to function of rumen of cow, that is, reduce propionic acid yield, improve acetic acid/propionic acid ratio.So in milk cow
Upper cinnamic acid and eugenol can play the role of substituting Rumensin.
Rumen bypass Cotton seeds are carried out to carvacrol and Thymol with carrier by rumen bypass, make carvacrol and thyme
Phenol is rumen-protected, to enable carvacrol and Thymol to play a role in enteron aisle.Carvacrol and Thymol are in intestines
Restraining and sterilizing bacteria effect is played in road, improves birth canal small intestinal villous height, reduces Crypt depth, while improving enteron aisle digestive enzyme
Property, and then the digestion, absorption and transhipment for improving enteron aisle to the nutriment of nutriment are played, dairy cattle is improved, is carried
High ox body immunity reduces somatic number in milk, reduces the effect of mammitis incidence.
Eugenol, cinnamic acid are conducive to using above-mentioned proportional region and give full play to positive effect effect in cud, reaches drop
Low rumen fluid ammonia nitrogen concentration reduces the third ratio of second, promotes the effect of rumen microorganism growth；The ratio of carvacrol, Thymol
Range can make carvacrol, Thymol play maximum effect in milk cow rear intestinal, preferably inhibit harmful bacteria growth, promote
Beneficial bacterium is proliferated, and is ensured intestinal microflora balance, is reached raising milk cow immunity, improve dairy cattle, improves and raise
Expect the purpose of conversion ratio.
Further, include the component of following parts by weight：In 3-5 parts of eugenol, 8-10 parts of cinnamic acid, 3-5 parts of carvacrol, hundred
10-40 parts of carrier of fragrant phenol 3-5 parts and rumen bypass.
Advantageous effect using the above scheme is：
Using above-mentioned proportional region, the successful preparation of sustained release coating and rumen bypass coating may further ensure that, it is ensured that
Eugenol and cinnamic acid play a role in cud, and Thymol and carvacrol play a role in rear intestinal.
Further, the rumen bypass is saturated fatty acid with carrier.
Take having the beneficial effect that for said program：Rumen bypass packet is carried out to carvacrol and Thymol by saturated fatty acid
Clothing processing, keeps carvacrol and Thymol rumen-protected, to enable carvacrol and Thymol to play work in enteron aisle
With.Carvacrol and Thymol play restraining and sterilizing bacteria effect in enteron aisle, improve birth canal small intestinal villous height, and it is deep to reduce crypts
Degree, while Activity of Digestive Enzymes in Intestine is improved, and then play and improve enteron aisle to the digestion of the nutriment of nutriment, absorption and turn
Fortune improves dairy cattle, improves ox body immunity, reduces somatic number in milk, reduces the effect of mammitis incidence.
Further, in the saturated fatty acid, including C16-C18 saturated fatty acids, the content of C16-C18 saturated fatty acids are
70% or more of saturated fatty acid.
Take having the beneficial effect that for said program：
Selection saturated fatty acid is more advantageous to product and passes through cud；Ruminant is conducive to full using C16-C18
Consumption with aliphatic acid is absorbed and is utilized.
Preferably, the content of C16-C18 can further increase utilizing status of the milk cow to aliphatic acid for 70% or more.
Further, the rumen bypass is selected from stearic acid, stearate, the hydrogenated fatty acid of animal or plant, fat with carrier
The mixing of one or more of fat alcohols or acrylic resin IV.
Having the beneficial effect that using the above scheme：
Be conducive to further increase the effect of rumen bypass using the aliphatic acid of mentioned kind.
Further, further include coating carrier 1-20 parts by weight and adsorbent 10-40 parts by weight
Further, further include solvent 20-60 parts by weight.The solvent can be water.
Take having the beneficial effect that for said program：
Cinnamic acid and eugenol have positive acting to ruminant tumor gastric function, you can to improve propionic acid yield in cud,
Acetic acid/propionic acid ratio is reduced, inhibits peptidase activity to reduce the concentration of ammoniacal nitrogen, improves the production performance of ruminant.And thyme
Phenol and carvacrol have negative role to function of rumen of cow, that is, reduce propionic acid yield, improve acetic acid/propionic acid ratio.So in milk cow
Upper cinnamic acid and eugenol can play the role of substituting Rumensin.
Sustained release coating processing is carried out to eugenol and cinnamic acid by coating carrier, makes cinnamic acid and eugenol with sustained release agent
Form exist, be conducive to extend the action time of eugenol and cinnamic acid in cud, keep its continual in cud
It plays a role.
Solvent is conducive to fully dissolve coating carrier, and eugenol and cinnamic acid is fully emulsified, is uniformly mixed, avoids fourth
Fragrant phenol, cinnamic acid volatilization；Adsorbent can make solvent adsorption, be conducive to avoid eugenol, cinnamic acid volatilization.
Further, the coating carrier includes methylcellulose and yellow mustard glue, and the parts by weight of methylcellulose are 0.5-10
Part, the parts by weight of yellow mustard glue are 0.5-10 parts.
It is used cooperatively as coating carrier and the suitable proportioning of setting, first for it using methylcellulose and yellow mustard glue
Any one of his raw material or methylcellulose and yellow mustard glue raw material, are more advantageous to slow release of the product in cud, reach
Slow release effect avoids essential oil from volatilizing and aoxidize, reduces effect.
Further, the methylcellulose is a kind of in hydroxymethyl cellulose, sodium carboxymethylcellulose and sodium alginate
Or several mixing；And/or the adsorbent is white carbon；And/or the solvent is water.
Advantageous effect using the above scheme is：
Be conducive to further increase the effect of coating using the methylcellulose of mentioned kind.
The present invention provides a kind of preparation method of above-mentioned milk cow plant essential oil composition, includes the following steps：
Carvacrol and Thymol are done into rumen bypass coating with rumen bypass with carrier, obtained product and eugenol and Chinese cassia tree
Aldehyde is uniformly mixed, and obtains milk cow plant essential oil composition.
Advantageous effect using the above scheme is：
Eugenol, cinnamic acid give full play to positive effect effect in cud, and reaching reduces rumen fluid ammonia nitrogen concentration, reduces second
Acid/propionic acid ratio promotes the effect of rumen microorganism growth.Carvacrol and Thymol were carried out with carrier by rumen bypass
Cud Cotton seeds keep carvacrol and Thymol rumen-protected, to enable carvacrol and Thymol in enteron aisle
It plays a role.Carvacrol and Thymol play restraining and sterilizing bacteria effect in enteron aisle, improve birth canal small intestinal villous height, reduce hidden
Nest depth, while Activity of Digestive Enzymes in Intestine is improved, and then play digestion, the absorption for improving enteron aisle to the nutriment of nutriment
And transhipment, dairy cattle is improved, ox body immunity is improved, reduces somatic number in milk, reduces the work of mammitis incidence
With.
The present invention also provides a kind of preparation methods of above-mentioned milk cow plant essential oil composition, include the following steps：
Coating carrier is dissolved in solvent, eugenol is added and cinnamic acid is uniformly mixed, is added and inhales in the product after mixing
Attached dose of absorption, obtains the first mixture；Carvacrol and Thymol are done into rumen bypass coating with carrier with rumen bypass, obtain second
Mixture；By the first mixture and the second mixture mixing, milk cow plant essential oil composition is obtained.
Advantageous effect using the above scheme is：
Sustained release agent replacement Rumensin is made in cinnamic acid and eugenol to play a role in cud, third can be further increased
Acid yield reduces the ratio of acetic acid/propionic acid, improves function of rumen, and it is more permanent to play a role.Carvacrol and Thymol are used
It is rumen-protected that restraining and sterilizing bacteria effect is played in enteron aisle, digestion, absorption and the transhipment of enteral nutrition substance are improved, ox body is improved
Immunity reduces somatic number in milk.
Further, the specific method for carvacrol and Thymol being done rumen bypass coating with rumen bypass with carrier includes following
Step：Rumen bypass is heated to melt with carrier, carvacrol and Thymol are added according to the ratio, mixing is spray-dried, is cold later
But.
Advantageous effect using the above scheme is：Be conducive to plants essential oil to be sufficiently mixed with saturated fatty acid, ensure product
The uniformity and rumen bypass rate.
Specific implementation mode
The principles and features of the present invention are described below, and the given examples are served only to explain the present invention, is not intended to limit
Determine the scope of the present invention.
A kind of milk cow plant essential oil composition, includes the component of following parts by weight：1-8 parts of eugenol, cinnamic acid 1-15
The mixture of part and the carvacrol and Thymol that are handled through rumen bypass, the carvacrol and Thymol of the rumen bypass processing
Mixture include 10-40 parts of 1-8 parts of carvacrol, 1-8 parts of Thymol and rumen bypass carrier.
When preparation, include the following steps：Carvacrol and Thymol are done into rumen bypass coating with carrier with rumen bypass, obtained
Product be uniformly mixed with eugenol and cinnamic acid, obtain milk cow plant essential oil composition
Preferably, in above-mentioned formula, eugenol 3-5 parts by weight, cinnamic acid 8-10 parts by weight, carvacrol 3-5 parts by weight, hundred
In fragrant phenol 3-5 parts by weight.
In above-mentioned formula, the rumen bypass is saturated fatty acid with carrier；
Preferably, the fusing point of saturated fatty acid is 52 DEG C or 52 DEG C or more.
Preferably, in the saturated fatty acid, the content of C16-C18 saturated fatty acids is 70% or more of saturated fatty acid.
Saturated fatty acid includes stearic acid, stearate, the hydrogenated fatty acid of animal or plant, aliphatic alcohols or acrylic acid
It can also be wherein several mixing that resin IV etc., which can be one such,.
In order to enhance the slow release effect of eugenol and cinnamic acid, a kind of milk cow plant essential oil composition, including it is following heavy
Measure the component of part：1-8 parts of eugenol, 1-15 parts of cinnamic acid, 1-8 parts of carvacrol, 1-8 parts of Thymol, rumen bypass carrier 10-
20-60 parts of 40 parts, 1-20 parts of coating carrier, 10-40 parts of adsorbent and solvent.Preferably, in above-mentioned formula, eugenol 3-5 weights
Measure part, cinnamic acid 8-10 parts by weight, carvacrol 3-5 parts by weight, Thymol 3-5 parts by weight.
The coating carrier includes methylcellulose and yellow mustard glue, and the parts by weight of methylcellulose are 0.5-10 parts, yellow mustard
The parts by weight of glue are 0.5-10 parts.
Yellow mustard glue refers to the colloid extracted from yellow mustard seeds, can prepare or purchased in market obtain by the conventional method of this field
.
Methylcellulose is a kind of substance that can be dissolved in water.The methylcellulose is selected from hydroxymethyl cellulose, carboxymethyl
It can also be wherein several mixing that sodium cellulosate and sodium alginate etc., which can be one of which,；And/or the adsorbent is white
Carbon black；And/or the solvent is water.
When preparation, include the following steps：
Coating carrier is dissolved in solvent, eugenol is added and cinnamic acid is uniformly mixed, is added into the product after mixing
Adsorbent adsorbs, and obtains the first mixture；Carvacrol and Thymol are done into rumen bypass coating with carrier with rumen bypass, obtain
Two mixtures；By the first mixture and the second mixture mixing, milk cow plant essential oil composition is obtained.
Note that the first mixture and the second mixture are merely for convenience of description, it is suitable the priority for limiting and preparing is not represented
Sequence.For example, it is also possible to the first mixture can also be prepared again by first preparing the second mixture, it can also be by the first mixture and second
Mixture is prepared simultaneously.
In above-mentioned steps, the specific method that carvacrol and Thymol are made to rumen bypass coating of rumen bypass of carrier includes
Following steps：Rumen bypass is heated to 90 DEG C of meltings with carrier, carvacrol is added according to the ratio and Thymol, mixing are sprayed later
Mist is dry, cooling.Rumen bypass is heated to 90 DEG C with carrier, is conducive to saturated fatty acid and fully melts, be conducive to plants essential oil
It is sufficiently mixed with saturated fatty acid, ensures the uniformity and rumen bypass rate of product.
Embodiment 1
This example prepares the milk cow plant essential oil composition of total plants essential oil content 10%, includes the following steps：
1) eugenol 30g, cinnamic acid 40g, carvacrol 10g are weighed, Thymol 20g is spare.
2) methylcellulose 8g and yellow 17 grams of mustard glue are weighed, the two is dissolved in 295ml distilled water, eugenol and meat is added
Cinnamic aldehyde is uniformly mixed, adds 180g white carbons, mixes, is adsorbed using white carbon, obtain the first mixture.
3) weighing saturated fatty acid 400g, (in the saturated fatty acid, the content of C16-C18 saturated fatty acids is 72%, is satisfied
Fusing point with aliphatic acid is 52 DEG C), 90 DEG C of meltings are heated to, carvacrol and Thymol and mixing are added into molten product,
Mixed product is sprayed onto in cooling tower by the nozzle of drying machine with centrifugal spray to get to the second mixture.
4) the first mixture and the second mixture are uniformly mixed, obtain the milk cow plant essence of plants essential oil content 10%
Fluid composition.
Embodiment 2
This example prepares the milk cow plant essential oil composition of total plants essential oil content 20%, includes the following steps：
1) eugenol 80g, cinnamic acid 70g, carvacrol 30g are weighed, Thymol 20g is spare.
2) methylcellulose 10g and yellow 20 grams of mustard glue are weighed, the two is dissolved in 200ml distilled water, be added eugenol and
Cinnamic acid is uniformly mixed, adds 400g white carbons, is uniformly mixed, is adsorbed using white carbon, obtain the first mixture.
3) weigh saturated fatty acid 170g (in the saturated fatty acid, the contents of C16-C18 saturated fatty acids is 72%,
The fusing point of saturated fatty acid is 52 DEG C), 90 DEG C of meltings are heated to, carvacrol and Thymol are added into molten product and mixes
It is even, mixed product is sprayed onto in cooling tower by the nozzle of drying machine with centrifugal spray to get the second mixture.
4) the first mixture and the second mixture are uniformly mixed, obtain the milk cow plant essence of plants essential oil content 20%
Fluid composition.
Embodiment 3
This example prepares the milk cow plant essential oil composition of total plants essential oil content 25%, includes the following steps：
1) eugenol 50g, cinnamic acid 100g, carvacrol 50g are weighed, Thymol 50g is spare.
2) methylcellulose 10g and yellow 20 grams of mustard glue are weighed, the two is dissolved in 350ml distilled water, be added eugenol and
Cinnamic acid is uniformly mixed, adds 200g white carbons, mixes, is adsorbed using white carbon, obtain the first mixture.
3) weighing saturated fatty acid 170g, (in the saturated fatty acid, the content of C16-C18 saturated fatty acids is 72%, is satisfied
Fusing point with aliphatic acid is 52 DEG C), 90 DEG C of meltings are heated to, carvacrol and Thymol and mixing are added into molten product,
Mixed product is sprayed onto in cooling tower by the nozzle of drying machine with centrifugal spray to get the second mixture.
4) the first mixture and the second mixture are uniformly mixed, obtain the milk cow plant essence of plants essential oil content 25%
Fluid composition.
Embodiment 4
On the basis of embodiment 1, the weight for the raw material for preparing milk cow plant essential oil composition is adjusted to：Eugenol
10g, cinnamic acid 10g, carvacrol 80g, Thymol 10g, methylcellulose 5g, yellow mustard glue 5g, saturated fatty acid 100g, hard charcoal
Black 100g and distilled water 600g, remaining is same as Example 1.The preparation method of milk cow plant essential oil composition and embodiment 1
It is identical.
Embodiment 5
On the basis of embodiment 1, the weight for the raw material for preparing milk cow plant essential oil composition is adjusted to：Eugenol
20g, cinnamic acid 150g, carvacrol 30g, Thymol 80g, methylcellulose 100g, yellow mustard glue 100g, saturated fatty acid
100g, white carbon 120g and distilled water 300g, remaining is same as Example 1.The preparation method of milk cow plant essential oil composition
It is same as Example 1.
Effect example
In order to verify the properties of product of plant essential oil composition prepared by the present invention, feeding experiment is carried out, feelings are embodied
Condition is as follows：
1, experimental animal
Select lactation age in days close (average according to principle similar in age, body condition, parity in certain intensive thousand pasture
Lactation age in days 80 days) healthy holstein cow 40, be randomly divided into 4 groups, every group 10.Wherein experimental group 30, is divided into I
Group, II groups, III groups, control group 10；Experimental group control group milk cow normally feeds according to NRC feeding standards.
2, experimental design
It tests in 8 days Mays in 2016, June, 7 end of day, added up to 30 days, and 3 test groups feed of the invention real respectively
Apply example 1, embodiment 2,3 resulting composition of embodiment, 2 gram/〃 days, control group Cow-feeding basal diet.
3, sample collection
Milk performance
The experimental group and control group 0d after on-test, 7d, 14d, 21d and 30d the record output of milk and newborn index and
Somatic number.
4, Indexs measure：
Newborn index：Use dairy products analyzer.
5, data processing：
Data analysis is carried out using spss19.0 data processing softwares, is as a result indicated with " mean+SD ".
6, experimental result
Influence to milk cow production performance is shown in Table 1：
Influence of the table 1 to milk cow production performance
Same column indicates that difference is not notable (P > 0.05) without letter or data shoulder mark same letter, different lowercase letters
Significant difference (P < 0.05), different capitalizations indicate difference extremely significantly (P < 0.01).
7, test result analysis
After above each index analysis result can be seen that feeding plant essential oil composition of the present invention, it can significantly improve
Milk production of cow, highest improve 3.5kg；Milk-quality is significantly improved, wherein lactoprotein and butterfat percnetage highest improves 0.2, lactose
Highest improves 0.35.This illustrates that the present composition can improve propionic acid yield, reduces the ratio of acetic acid/propionic acid, improves cud
Function.Meanwhile rumen bypass carvacrol and Thymol play a role in enteron aisle, improve enteron aisle height of naps, and it is deep to reduce crypts
Degree improves digestive enzyme activity, increases digestibility of the milk cow to nutriment, improves efficiency of feed utilization.And then improve milk cow
Milk yield and breast matter amount.In addition, the present composition can enhance milk cow immunity of organisms, milk cow premunition is improved, is reduced
Somatic number in milk improves milk-quality.
Embodiment 4 can also obtain similar effect with embodiment 5.
Inventor further study show that, in the case where other raw materials are constant, using " eugenol 3-5 parts by weight, Chinese cassia tree
Aldehyde 8-10 parts by weight, carvacrol 3-5 parts by weight, Thymol 3-5 parts by weight " production performance can further increase.
In conclusion experiment through the invention can illustrate, sustained release agent, which is made, in cinnamic acid and eugenol substitutes cud
Element plays a role in cud, promotes the proliferation of rumen microorganism in cud, improves Volatile fatty acid contents in cud, can
To improve propionic acid yield, the ratio of acetic acid/propionic acid is reduced, improves function of rumen.
Rumen bypass is made in carvacrol and Thymol, allows its safety cud, is played a role in enteron aisle.Sheep's-parsley
Phenol and Thymol discharge in enteron aisle, and lactic acid bacteria and Bifidobacterium proliferation, suppression in enteron aisle is promoted to kill enteron aisle Escherichia coli, sramana
The harmful bacterias such as Salmonella improve nutrient digestion, absorption and transhipment.Somatic number is reduced simultaneously, reduces the incidence of mammitis,
And protein ratio and butter oil rate can be improved while improving the output of milk.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of milk cow plant essential oil composition, which is characterized in that include the component of following parts by weight：1-8 parts of eugenol, meat
The mixture of 1-15 parts of cinnamic aldehyde and the carvacrol and Thymol that are handled through rumen bypass, the carvacrol of rumen bypass processing and
The mixture of Thymol includes 10-40 parts of 1-8 parts of carvacrol, 1-8 parts of Thymol and rumen bypass carrier.
2. a kind of milk cow plant essential oil composition according to claim 1, which is characterized in that include the group of following parts by weight
Point：10-40 parts of carrier of 3-5 parts of eugenol, 8-10 parts of cinnamic acid, 3-5 parts of carvacrol, 3-5 parts of Thymol and rumen bypass.
3. a kind of milk cow plant essential oil composition according to claim 1, which is characterized in that the rumen bypass is with carrier
Saturated fatty acid；In the saturated fatty acid, including C16-C18 saturated fatty acids, the content of C16-C18 saturated fatty acids is saturation
70% or more of aliphatic acid.
4. a kind of milk cow plant essential oil composition according to claim 1, which is characterized in that the rumen bypass is selected with carrier
From one or more of stearic acid, stearate, the hydrogenated fatty acid of animal or plant, aliphatic alcohols or acrylic resin IV
Mixing.
5. according to a kind of any one of claim 1-4 milk cow plant essential oil compositions, which is characterized in that further include coating
Carrier 1-20 parts by weight and adsorbent 10-40 parts by weight.
6. a kind of milk cow plant essential oil composition according to claim 5, which is characterized in that further include solvent 20-60 weights
Part is measured, the solvent is water.
7. a kind of milk cow plant essential oil composition according to claim 6, which is characterized in that the coating carrier includes first
The parts by weight of base cellulose and yellow mustard glue, methylcellulose are 0.5-10 parts, and the parts by weight of yellow mustard glue are 0.5-10 parts, the first
The mixing one or more of in hydroxymethyl cellulose, sodium carboxymethylcellulose and sodium alginate of base cellulose, the absorption
Agent is white carbon.
8. a kind of preparation method of any one of claim 1-4 milk cow plant essential oil compositions, which is characterized in that including
Following steps：
Carvacrol and Thymol are done into rumen bypass coating with rumen bypass with carrier, obtained product and eugenol and cinnamic acid are mixed
It closes uniformly, obtains milk cow plant essential oil composition.
9. a kind of preparation method of the 6 or 7 milk cow plant essential oil composition of claim, which is characterized in that including following
Step：
Coating carrier is dissolved in solvent, eugenol is added and cinnamic acid is uniformly mixed, adsorbent is added in the product after mixing
Absorption, obtains the first mixture；Carvacrol and Thymol are done into rumen bypass coating with carrier with rumen bypass, obtain the second mixing
Object；By the first mixture and the second mixture mixing, milk cow plant essential oil composition is obtained.
10. the preparation method of milk cow plant essential oil composition according to claim 9, which is characterized in that by carvacrol and
The specific method that Thymol makes rumen bypass coating of rumen bypass of carrier includes the following steps：Rumen bypass is heated to carrier
Melting, is added carvacrol and Thymol according to the ratio, and mixing is spray-dried, is cooling later.
Priority Applications (1)
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| CN110353114A (en) * | 2019-08-22 | 2019-10-22 | 南京泛成生物科技有限公司 | A kind of cow feed additive and its preparation process |
| CN113796393B (en) * | 2020-06-17 | 2023-06-27 | 迈迪生物科技有限公司 | Environment-friendly essential oil emulsion with lasting slow release capability and preparation method and application thereof |
| CN112075538A (en) * | 2020-09-16 | 2020-12-15 | 谷实生物集团股份有限公司 | Formula for improving meat tenderness and intramuscular fat content of beef cattle and processing technology |
| CN112586610A (en) * | 2020-12-15 | 2021-04-02 | 张德奎 | Extended release formulation for antibiotic replacement therapy |
| CN113892561A (en) * | 2021-10-27 | 2022-01-07 | 潍坊加易加生物科技有限公司 | Slow-release feed additive for pigs and poultry and preparation method and application thereof |
| CN116035125A (en) * | 2023-03-07 | 2023-05-02 | 吉林省农业科学院 | Rumen slow-release methane inhibitor for cattle and sheep and production method thereof |
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