CN106962420A - A kind of disposable thimerosal based on plant extracts and preparation method thereof - Google Patents

A kind of disposable thimerosal based on plant extracts and preparation method thereof Download PDF

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Publication number
CN106962420A
CN106962420A CN201710344213.XA CN201710344213A CN106962420A CN 106962420 A CN106962420 A CN 106962420A CN 201710344213 A CN201710344213 A CN 201710344213A CN 106962420 A CN106962420 A CN 106962420A
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CN
China
Prior art keywords
plant extracts
thimerosal
disposable
preparation
disposable thimerosal
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Pending
Application number
CN201710344213.XA
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Chinese (zh)
Inventor
陈嘉
张明灯
王琳
施雪涛
林成燊
张伟
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Guangzhou Peptide Biotechnology Co Ltd
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Guangzhou Peptide Biotechnology Co Ltd
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Priority to CN201710344213.XA priority Critical patent/CN106962420A/en
Publication of CN106962420A publication Critical patent/CN106962420A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
    • A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A01N65/36—Rutaceae [Rue family], e.g. lime, orange, lemon, corktree or pricklyash

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Pest Control & Pesticides (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)

Abstract

The invention belongs to Field of Fine Chemicals, a kind of disposable thimerosal based on plant extracts and preparation method thereof is specifically disclosed.The disposable thimerosal each component and weight/mass percentage composition based on plant extracts are as follows：Grapefruit seed extract is 0.05~10%, and Tea Polyphenols is 0.01~10%, and Tween 80 is 0~3%, and sodium citrate is 0~1%, and fermenting alcohol is 35~99.4%, and surplus is pure water.Disposable thimerosal of the present invention based on plant extracts belongs to plant extracts disinfectant preparation, and available for fruit cleaning, chopping board and mould proof, the kitchen and bath's sterilization of furniture etc., safety non-toxic simultaneously can be from cleaning；Disinfection Effect is excellent, environmentally safe.

Description

A kind of disposable thimerosal based on plant extracts and preparation method thereof
Technical field
The invention belongs to Field of Fine Chemicals, it is related to a Plant Extracts disinfectant preparation, more particularly to one kind is based on Disposable thimerosal of safety non-toxic of plant extracts and preparation method thereof.
Background technology
There is substantial amounts of bacterium among environment for human survival.These bacteriums are harmless a bit, but some can cause seriously Disease, threaten human health.In view of the haze weather in the wet weather of southern china and the north, and people are to height life matter The continuous pursuit of amount, how effectively the bacterium in suppression living environment, life of keeping fit, are the mankind's chasing after all the time Ask.In order to kill bacterium, the mankind employ a variety of bactericide.But bactericide at present all exist it is very big the problem of.Such as The most frequently used alcohol can cause oral cavity canceration；Antibiotic can reduce body immunity, and produce " superbacteria "；More for another example Synthetic antibacterial agents, are such as used for " triclosan " of toothpaste, are also found to have carcinogenic phenomenon.
The content of the invention
In order to overcome a series of problems present in current thimerosal, primary and foremost purpose of the invention is to provide a kind of based on plant The disposable thimerosal of safety non-toxic that thing extract is made, it is a further object to provide the preparation side of the thimerosal Method.
The object of the invention is achieved through the following technical solutions：
A kind of disposable thimerosal based on plant extracts, using the disposable thimerosal gross mass based on plant extracts as 100% meter, each component and weight/mass percentage composition are as follows：Grapefruit seed extract is 0.05~10%, and Tea Polyphenols is 0.01~10%, Tween 80 is 0~3%, and sodium citrate is 0~1%, and fermenting alcohol is 35~99.4%, and surplus is pure water.Further, it is described Component preferred weight percentage composition is as follows：Grapefruit seed extract is 2%, and Tea Polyphenols is 1%, and Tween 80 is 0.1%, and sodium citrate is 0.2%, fermenting alcohol is 35%, and surplus is pure water.
The Tea Polyphenols be green-tea extract, the Tween 80 and sodium citrate be pharmaceutical grade or food-grade commercially available prod, The fermenting alcohol is ethanol made from saccharomycetes to make fermentation, and the pure water is food-grade pure water.
Major antibacterial composition is grapefruit seed extract and Tea Polyphenols, tool in the disposable thimerosal based on plant extracts There is the effect such as removing free radical, antibacterial, antiviral.
A kind of preparation method of the disposable thimerosal based on plant extracts, its step is：
（1）By 0.05~10% grapefruit seed extract, 0.01~10% Tea Polyphenols, 0~3% Tween 80 and 35~99.4% fermentations Ethanol is mixed, and is stirred, is obtained mixed solution a；
（2）Pure water is added in mixed solution a, stirred, and with the pH value of 0~1% sodium citrate regulation solution to 4~ 8, stirring obtains the disposable thimerosal of the present invention based on plant extracts to solution clarification.
Compared with prior art, the present invention has advantages below and beneficial effect：
（1）Disposable thimerosal of the present invention based on plant extracts, the west of its major antibacterial composition excellent antibacterial effect Shaddock seed extract and green-tea extract（Tea Polyphenols）, major antibacterial composition is direct to be extracted from plant, and safety non-toxic is edible With, can from cleaning；The disposable thimerosal can be used for cleaning fruit and directly eat；Table trencher or knife can also be sprayed at On tool, prevent its mouldy；Wardrobe or toilet can also be sprayed at, the peculiar smell that bacterium and mould bring is eliminated；
（2）Disposable thimerosal of the present invention based on plant extracts, can effectively reduce fruit, chopping board surface and health Between bacterial concentration, it is excellent to the bactericidal effect of staphylococcus aureus, Escherichia coli and mould, it is environmentally safe.
Embodiment
With reference to embodiment, the present invention is described in further detail, but the implementation of the present invention is not limited to this.
Embodiment 1
A kind of disposable thimerosal based on plant extracts, each component and weight/mass percentage composition are as follows：Grapefruit seed extract is 2%, Tea Polyphenols is 1%, and Tween 80 is 0.1%, and sodium citrate is 0.2%, and fermenting alcohol is 35%, and pure water is 61.7%.It is described to be based on planting The pH value of the disposable thimerosal of thing extract is 4.6.Prepared thimerosal is made after spray, according to 1mL/m2Consumption It is sprayed on apple, apple surface work bacterial number（cuf/m2）：It is 882 ± 139 before sprinkling, is 89 ± 12 after sprinkling；According to 1mL/m2Consumption be sprayed on table trencher, plate surface of cutting the dish live bacterial number（cuf/m2）：It is 1827 ± 221, sprinkling before sprinkling It is 120 ± 32 afterwards；According to 3mL/m3Consumption be sprayed in toilet, bacterial number living in toilet（cuf/m3）：It is before sprinkling 50341 ± 3215, it is 8939 ± 819 after sprinkling；Disinfection Effect is excellent.In the lab, using pure water according to 1:100 dilutions Thimerosal afterwards, the sterilizing rate to staphylococcus aureus in 5 minutes is 99.12%, is to the sterilizing rate of Escherichia coli 99.27%, the sterilizing rate to Pseudomonas aeruginosa is 99.93%.
Embodiment 2
A kind of disposable thimerosal based on plant extracts, each component and weight/mass percentage composition are as follows：Grapefruit seed extract is 0.05%, Tea Polyphenols is 0.01%, and Tween 80 is 0%, and sodium citrate is 0.1%, and fermenting alcohol is 99.4%, and pure water is 0.44%. The pH value of the disposable thimerosal based on plant extracts is 4.0.Prepared thimerosal is made after spray, according to 1mL/m2Consumption be sprayed on apple, apple surface live bacterial number（cuf/m2）：It is 882 ± 139 before sprinkling, is after sprinkling 289±57；According to 1mL/m2Consumption be sprayed on table trencher, plate surface of cutting the dish live bacterial number（cuf/m2）：It is before sprinkling 1827 ± 221, it is 811 ± 156 after sprinkling；According to 3mL/m3Consumption be sprayed in toilet, bacterial number living in toilet （cuf/m3）：It is 50341 ± 3215 before sprinkling, is 23212 ± 2220 after sprinkling.In the lab, using pure water according to 1: Thimerosal after 100 dilutions, the sterilizing rate to staphylococcus aureus in 5 minutes is 81.21%, the sterilization to Escherichia coli Rate is 65.12%, and the sterilizing rate to Pseudomonas aeruginosa is 50.32%.
Embodiment 3
A kind of disposable thimerosal based on plant extracts, each component and weight/mass percentage composition are as follows：Grapefruit seed extract is 10%, Tea Polyphenols is 10%, and Tween 80 is 0%, and sodium citrate is 0%, and fermenting alcohol is 70%, and pure water is 10%.It is described to be based on planting The pH value of the disposable thimerosal of thing extract is 8.0.Prepared thimerosal is made after spray, according to 1mL/m2Consumption It is sprayed on apple, apple surface work bacterial number（cuf/m2）：It is 882 ± 139 before sprinkling, is 102 ± 33 after sprinkling；According to 1mL/m2Consumption be sprayed on table trencher, plate surface of cutting the dish live bacterial number（cuf/m2）：It is 1827 ± 221, sprinkling before sprinkling It is 183 ± 58 afterwards；According to 3mL/m3Consumption be sprayed in toilet, bacterial number living in toilet（cuf/m3）：It is before sprinkling 50341 ± 3215, it is 10289 ± 1331 after sprinkling.In the lab, using pure water according to 1:Thimerosal after 100 dilutions, Sterilizing rate to staphylococcus aureus in 5 minutes is 98.89%, and the sterilizing rate to Escherichia coli is 97.52%, to green pus The sterilizing rate of bacillus is 94.98%.
Embodiment 4
A kind of disposable thimerosal based on plant extracts, each component and weight/mass percentage composition are as follows：Grapefruit seed extract is 3%, Tea Polyphenols is 0.2%, and Tween 80 is 3%, and sodium citrate is 1%, and fermenting alcohol is 65%, and pure water is 27.8%.It is described to be based on plant The pH value of the disposable thimerosal of extract is 4.2.Prepared thimerosal is made after spray, according to 1mL/m2Consumption spray Spill on apple, apple surface is lived bacterial number（cuf/m2）：It is 882 ± 139 before sprinkling, is 289 ± 78 after sprinkling；According to 1mL/m2Consumption be sprayed on table trencher, plate surface of cutting the dish live bacterial number（cuf/m2）：It is 1827 ± 221, sprinkling before sprinkling It is 331 ± 95 afterwards；According to 3mL/m3Consumption be sprayed in toilet, bacterial number living in toilet（cuf/m3）：It is before sprinkling 50341 ± 3215, it is 19937 ± 1242 after sprinkling.In the lab, using pure water according to 1:Thimerosal after 100 dilutions, Sterilizing rate to staphylococcus aureus in 5 minutes is 97.16%, and the sterilizing rate to Escherichia coli is 98.09%, to green pus The sterilizing rate of bacillus is 97.33%.
Above-described embodiment is preferably embodiment, but embodiments of the present invention are not by above-described embodiment of the invention Limitation, other any Spirit Essences without departing from the present invention and the change made under principle, modification, replacement, combine, simplification, Equivalent substitute mode is should be, is included within protection scope of the present invention.

Claims (4)

1. a kind of disposable thimerosal based on plant extracts, it is characterised in that disappeared with disposable based on plant extracts Venom gross mass is 100% meter, and each component and weight/mass percentage composition are as follows：Grapefruit seed extract is 0.05~10%, and Tea Polyphenols is 0.01~10%, Tween 80 is 0~3%, and sodium citrate is 0~1%, and fermenting alcohol is 35~99.4%, and surplus is pure water.
2. the disposable thimerosal according to claim 1 based on plant extracts, it is characterised in that the Tea Polyphenols is green Tea extraction.
3. the disposable thimerosal according to claim 1 based on plant extracts, it is characterised in that the fermenting alcohol is Ethanol made from saccharomycetes to make fermentation.
4. the preparation method of the disposable thimerosal based on plant extracts described in any one of claims 1 to 3, its feature exists In the preparation method comprises the following steps：
（1）By 0.05~10% grapefruit seed extract, 0.01~10% Tea Polyphenols, 0~3% Tween 80 and 35~99.4% fermentations Ethanol is mixed, and is stirred, is obtained mixed solution a；
（2）Pure water is added in mixed solution a, stirred, and with the pH value of 0~1% sodium citrate regulation solution to 4~ 8, stirring obtains the disposable thimerosal of the present invention based on plant extracts to solution clarification.
CN201710344213.XA 2017-05-16 2017-05-16 A kind of disposable thimerosal based on plant extracts and preparation method thereof Pending CN106962420A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108703921A (en) * 2018-09-08 2018-10-26 山东卓健医疗科技有限公司 Children's virus rapid-curing cutback hand sanitizing fluid
CN108743702A (en) * 2018-06-09 2018-11-06 江苏海尔滋生物科技有限公司 A kind of anti-haze poison spray and preparation method thereof
CN112111339A (en) * 2020-09-30 2020-12-22 贵州中志农业科技有限公司 No-clean lemon cleaning agent

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108743702A (en) * 2018-06-09 2018-11-06 江苏海尔滋生物科技有限公司 A kind of anti-haze poison spray and preparation method thereof
CN108703921A (en) * 2018-09-08 2018-10-26 山东卓健医疗科技有限公司 Children's virus rapid-curing cutback hand sanitizing fluid
CN112111339A (en) * 2020-09-30 2020-12-22 贵州中志农业科技有限公司 No-clean lemon cleaning agent

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