CN106942227A - A kind of bactericidal composition containing mandestrobin and its application - Google Patents
A kind of bactericidal composition containing mandestrobin and its application Download PDFInfo
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- CN106942227A CN106942227A CN201710247101.2A CN201710247101A CN106942227A CN 106942227 A CN106942227 A CN 106942227A CN 201710247101 A CN201710247101 A CN 201710247101A CN 106942227 A CN106942227 A CN 106942227A
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- Prior art keywords
- mandestrobin
- metrafenone
- bactericidal composition
- mass ratio
- composition containing
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of bactericidal composition containing mandestrobin, its active ingredient is mandestrobin and metrafenone, and both mass ratioes are 1:50~50:1.The multiple diseases that the present composition can be used on preventing and treating crops, be particularly suitable for use in preventing and treating kernel approaches, pomaceous fruit and berry fruits powdery mildew, with the features such as dosage is low, synergistic effect is obvious, security is good.
Description
Technical field
The present invention relates to a kind of composition pesticide, more particularly to a kind of bactericidal composition containing mandestrobin and its
The application of disease on crops is prevented and treated, belongs to technical field of pesticide.
Background technology
Mandestrobin is the methoxy acrylic bactericide of SUMITOMO CHEMICAL exploitation, is that cytochrome b c1 is combined
Thing inhibitor, the features such as with wide spectrum, interior suction, preventative pesticide supplying effect is optimal.In recent years in European Union, Canada and the big profit of Australia
Asia registered, be mainly used in preventing and treating kernel approaches (apricot, cherry, peach, Lee) brown rot, fruit white rot of grape, gray mold and powdery mildew,
The diseases such as grey mould fruit rot of strawberry, sclerotinia rot of colza and Diseases of Turfgrass, effective ingredient consumption is 210-420g/hm2.It is particularly suitable for
Compounding exploitation is carried out from the bactericide of the different mechanisms of action.
Metrafenone, english common name：Metrafenone, is the new type bactericide developed by BASF AG.To paddy
Powdery mildew on the crops such as thing, grape, cucumber, peach, cherry has special efficacy, while protruding take-all effect.It acts on machine
Reason is novel, adheres to the development and formation of spore during spore germination by disturbing, suppresses the spore germination of powdery mildew；Secondly, by dry
The foundation and formation of polarity actin tissue are disturbed, the formation of the mycelium apical cell of germ is interfered and is suppressed, from
And mycelial normal development and growth are hindered, suppress and hinder the infringement of Powdery Mildew.Metrafenone is registered in China,
42%SC, effective ingredient consumption is 90-180g/hm2。
In production practices, powdery mildew easily develops immunity to drugs, and triazole type, methoxy acrylic is currently mainly used and kills
The medicaments such as microbial inoculum are prevented and treated, such as Tebuconazole and Fluoxastrobin.Due to obvious using causing resistance to rise for many years, under prevention effect
Drop, therefore it is badly in need of the new pesticide control of research and development.At present, there is not yet metrafenone carries out compounding exploitation use with mandestrobin
In the relevant report for preventing and treating powdery mildew.
The content of the invention
It is an object of the invention to provide a kind of synergistic effect is obvious, dosage is low, security good, be adapted to agriculturally produce
A kind of bactericidal composition containing mandestrobin used.
To achieve the above object of the invention, the technical solution adopted by the present invention is：
A kind of bactericidal composition containing mandestrobin, it is characterised in that：Contain active ingredient mandestrobin
And metrafenone, both mass ratioes are 1:50-50:1, preferred mass ratio is 1:10-10:1, more preferably mass ratio is 1:5-5:1.
The gross mass percentage composition of the bactericidal composition active ingredient be 5%-80%, remaining be auxiliary agent, carrier and its
He is beneficial to the effective ingredient known substance that stable and drug effect is played in storage and use.
The bactericidal composition can be prepared with conventional method, i.e. the active compound containing effective ingredient and suitable auxiliary agent, can
Any formulation agriculturally allowed with being processed into, preferable formulation have missible oil, microemulsion, aqueous emulsion, suspending agent, dry suspending agent,
Microcapsule suspending agent, water dispersible granules, wettable powder or soluble granule.
Powdery mildew, gray mold, brown rot, sclerotiniose, the full rot of the bactericidal composition on Different Crop is prevented and treated etc.
The application of disease, is particularly suitable for use in preventing and treating including powdery mildew on the berries including grape, apricot, cherry, Lee and stone fruit
Application.
Bactericidal composition of the present invention compared with prior art, can at least produce following beneficial effect：
(1), can be effective with notable synergistic effect after two kinds of active ingredients are compounded according to the above ratio in the present composition
Delay the drug-fast generation of pathogen；
(2) production Pesticides usage amount and access times, reduction production and use cost are effectively reduced, further effectively
Reduce environmental pollution and residues of pesticides.
Embodiment
For the object, technical solutions and advantages of the present invention are more clearly understood, with reference to embodiment in the present invention
Appearance is described further, but the present invention is limited to absolutely not these examples.
After the pesticide active ingredient mixing of different types of structure, three kinds of type of action, i.e. summation action, increasing are typically exhibited
Effect is acted on and antagonism, but is specially which kind of effect, it is impossible to predicted, only just be can know that by substantial amounts of experiment.
Assays Example：Mandestrobin is compounded with metrafenone and the Toxicity Determination of grape powdery mildew is tried
Test
Subjects：Grape powdery mildew (Uncinula necator Schw, Burr)
Test method：
(Deng Lijun etc., melon powdery mildew Isolated leaf inoculation technique study, Chinese melon are determined using Isolated leaf inoculation method
Dish, 2015,28 (3)：18-21.).Medicament is made into series concentration on the basis of trial test, each concentration, which is set, to be repeated 4 times, and is set
Blank control.Blade disease-free on new slightly the 5th, the 6 section position of susceptible variety grape (Carignan) is chosen, the petiole of 0.5cm length is stayed, uses
Scissors is chamfer, and running water is rinsed 2 times, then soaks 10S with 75% ethanol, then is rinsed 2 times with distilled water, is placed in 5% time
Soaking disinfection 3min in sodium chlorate, then with aseptic water washing 3 times.Blade is placed in super-clean bench and is covered with sterilized filter paper
In culture dish, after water is blotted, petiole is inserted in the double layer culture dish device equipped with sterilized water.With hedgehog hydnum sprayer by decoction
Uniformly it is sprayed onto on grape leave, is defined by leaf surface in moisture film shape.By on the grape leave for infecting powdery mildew after decoction is dry
Powdery Mildew spore be configured to 1 × 10 with sterilized water5Individual/mL spore suspension, takes 20 μ L bacterium solutions uniform with liquid-transfering gun
Be inoculated in face of blade, be put into 22 DEG C, relative humidity 70%, intensity of illumination be 2000Lx, the photoperiod is 10-14 hours/day
Cultivated 7 days in incubator.Incidence is investigated after 5-7 days, preventive effect is calculated.Sick leaf grade scale refers to NY/T 1156.4-
2006。
Statistical analysis is carried out with DPS statistical analysis softwares, the EC of each medicament is calculated50, and mixture is calculated according to the abundant methods of Sun Yun
Co-toxicity coefficient (CTC).
The computing formula of co-toxicity coefficient is as follows：
Survey toxicity index (ATI)=(standard agent EC50/ reagent agent EC50)×100
In theoretical toxicity index (TTI)=A medicaments ATI × mixture in A percentage composition+B medicaments ATI × mixture B hundred
Divide content
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/mixture theoretical toxicity index (TTI)] × 100
When CTC≤80, then composition shows as antagonism, as 80 ＜ CTC ＜ 120, then composition shows as being added and made
With when CTC >=120, then composition shows as synergistic effect.Toxicity Determination is the results detailed in Table 1.
Table 1mandestrobin compounds the Toxicity Determination result of the test to grape powdery mildew with metrafenone
Toxicity Determination result of the test shows in table 1, and mandestrobin is compounded 1 with metrafenone:50-50:1 proportioning
In the range of 120 are all higher than to the toxicity test co-toxicity coefficient of grape powdery mildew, show as synergistic effect.Particularly match 1:
5-5:When between 1, listed proportioning co-toxicity coefficient is above 200, and synergistic effect is most obvious.
Bactericidal composition of the present invention can be according to the crop of required preventing and treating, local environment condition, prevention and controls, cost accounting
Deng various factors, effective ingredient is processed into acceptable formulation in pesticides application, preferable agent together with auxiliary agent and carrier
Type has missible oil, microemulsion, aqueous emulsion, suspending agent, dry suspending agent, microcapsule suspending agent, water dispersible granules, wettable powder or solvable
Granula.Adjuvant used, carrier and process technology are using known component.In above-mentioned various formulations, effective active in composition
The gross mass percentage composition of composition is 5%-80%, for example, when mandestrobin and metrafenone weight/mass percentage composition are respectively
When 5% and 1%, gross mass percentage composition is 6%.
Example of formulations 1：
Weigh mandestrobin active compounds, metrafenone active compound and corresponding additive in mass ratio, using wet granulation it is size-reduced,
Be mixed, granulate, sieve after be made water dispersible granules of the present invention.
The mass ratio of mandestrobin and metrafenone can be 50 in the present embodiment：1~1：Change between 50, Liang Zhezong
Weight/mass percentage composition be still 51%, form new embodiment.
Example of formulations 2：
Mandestrobin active compounds, metrafenone active compound and corresponding additive are weighed in mass ratio, by filler, active compound, auxiliary agent
Mixture, it is levigate, mixing etc. process be made wettable powder of the present invention.
The mass ratio of mandestrobin and metrafenone can be 50 in the present embodiment：1~1：50 (examples 50：1、10：1、1：
1、1：10、1:50) change between, both total weight/mass percentage compositions are still 51%, form new embodiment.
Example of formulations 3：
Weigh mandestrobin active compounds, metrafenone active compound and emulsifying agent, solvent in mass ratio, by mandestrobin,
Metrafenone active compound, most of turpentine-based vegetable oil ND-45 input modulation kettles, start agitator and are mixed, original is made under agitation
Medicine is dissolved in solvent；After (if needing cooling when temperature is higher) after active compound all dissolving, agriculture breast 600#, agriculture breast are added
2000# and remaining solvent continue to mix, and temperature in the kettle is down into room temperature after mixing, that is, missible oil system of the present invention is made
Agent.
The mass ratio of mandestrobin and metrafenone can be 50 in the present embodiment：1~1：50 (examples 50：1、10：1、1：
1、1：10、1:50) change between, both total weight/mass percentage compositions are still 22%, form new example of formulations.
Example of formulations 4：
By recipe requirements, mandestrobin active compounds, metrafenone active compound, cosolvent, emulsifying agent, antifreezing agent etc. are mixed and stirred
Mix dissolving and oil phase is made, under 60-90r/min stirrings and high shear forces, deionized water is directly added into oil phase, stir about
30min, produces aqueous emulsion product of the present invention.
The mass ratio of mandestrobin and metrafenone can be 50 in this example of formulations：1~1：50 (examples 50：1、10：
1、1：1、1：10、1:50) change between, both total weight/mass percentage compositions are still 11%, form new embodiment.
Example of formulations 5：
By recipe requirements, mandestrobin active compounds, metrafenone active compound, cosolvent, emulsifying agent are mixed into dissolving system
Into oil phase, under 60-90r/min stirring actions, deionized water is directly added into oil phase, 15-30min is stirred, obtains transparent liquid
Body.Microemulsion of the present invention is produced after analyzing each qualified.
The mass ratio of mandestrobin and metrafenone can be 50 in the present embodiment：1~1：50 (examples 50：1、10：1、1：
1、1：10、1:50) change between, both total weight/mass percentage compositions are still 24%, form new embodiment.
Example of formulations 6：
According to formula, in the dispersion tank of high speed agitator is had, active compound and calcium lignosulfonate are dispersed in water, slightly
Crush active compound；This mixture through coarse crushing is continually fed into grater with constant displacement pump, carried out finely pulverized；With medium
Separation, the material of discharge send into last blending tank, the methocel solution modulated in addition are added blending tank, with having crushed
Material equably mix, obtain final suspending agent.
The mass ratio of mandestrobin and metrafenone can be 50 in the present embodiment：1~1：50 (examples 50：1、10：1、1：
1、1：10、1:50) change between, both total weight/mass percentage compositions are still 48%, form new embodiment.
Example of formulations 7：
According to formula, in the dispersion tank of high speed agitator is had, active compound and calcium lignosulfonate are dispersed in water, slightly
Crush active compound；This mixture through coarse crushing is continually fed into grater with constant displacement pump, carried out finely pulverized；With medium
Separation, the material of discharge send into last blending tank, the methocel solution modulated in addition are added blending tank, with having crushed
Material equably mix, obtain final suspending agent.
The mass ratio of mandestrobin and metrafenone can be 50 in the present embodiment：1~1：50 (examples 50：1、10：1、1：
1、1：10、1:50) change between, both total weight/mass percentage compositions are still 42%, form new embodiment.
Example of formulations 8：
Weigh in mass ratio mandestrobin active compounds, metrafenone active compound and corresponding additive, filler etc. be mixed into it is homogeneous
Powder, is passed through the water slurry that certain solid content is made through being sanded for sand mill, and average grain diameter is 2 μm -5 μm, then hangs water
Supernatant liquid is by being spray-dried granulating, so that final dry suspending agent is made.
The mass ratio of mandestrobin and metrafenone can be 50 in the present embodiment：1~1：50 (examples 50：1、10：1、1：
1、1：10、1:50) change between, both total weight/mass percentage compositions are still 60%, form new embodiment.
Example of formulations 9：
Mandestrobin active compounds, metrafenone active compound and corresponding additive etc. are weighed in mass ratio, are mixed, compounding kettle stirring,
Oil phase, then clipped scattered solidify afterwards encystation mixed with water is made, microcapsule suspending agent product is made.
The mass ratio of mandestrobin and metrafenone can be 50 in the present embodiment：1~1：50 (examples 50：1、10：1、1：
1、1：10、1:50) change between, both total weight/mass percentage compositions are still 44%, form new embodiment.
Example of formulations 10：
Weigh mandestrobin active compounds, metrafenone active compound and corresponding additive etc. in mass ratio, it is size-reduced, mix, mediate,
After extruding, dry filter, soluble granule product is made.
The mass ratio of mandestrobin and metrafenone can be 50 in the present embodiment：1~1：50 (examples 50：1、10：1、1：
1、1：10、1:50) change between, both total weight/mass percentage compositions are still 80%, form new embodiment.
Example of formulations 11
By recipe requirements, mandestrobin active compounds, metrafenone active compound, cosolvent, emulsifying agent, antifreezing agent etc. are mixed and stirred
Mix dissolving and oil phase is made, under 60-90r/min stirrings and high shear forces, deionized water is directly added into oil phase, stir about
30min, produces aqueous emulsion product of the present invention.
Nylar can be 50 with the mass ratio of pyridine quinazoline in this example of formulations：1~1：50 (examples 50：1、10：1、
1：1、1：10、1:50) change between, both total weight/mass percentage compositions are still 5%, form new embodiment.
Field information embodiment：Mandestrobin compounds the field control effectiveness test to uncinula necator with metrafenone
Experiment is carried out on Liaoning Province's Xingcheng City grape Demonstration Garden summer black grape, and experimental field former years powdery mildew occurs heavier.
Test medicine and dosage refer to table 2, often handle 4 repetitions, per 8 plants of grapes of cell, totally 52 cells, random district's groups arrangement.Adopt
Conventional spray-on process is used, decoction consumption is 5L/ areas, uniformly sprays complete stool, do not dripped for degree with squirting blade.Carry out at the initial stage of a disease
First time dispenser, carries out second of dispenser after 12 days, separately set clear water and be processed as blank control.State of an illness radix is investigated before dispenser,
With 14 days investigation prevention effects after second of dispenser before second of dispenser.10 young sprouts are investigated per cell, per the tip from top to bottom certainly
5th leaf is instituted an inquiry, and investigates 10 leaves, and the percentage that every leaf accounts for full wafer leaf area by lesion area is classified, and is classified
Standard is referring to NY/T 1464.12-2007.
Table 2mandestrobin compounds the field control effectiveness test result to uncinula necator with metrafenone
Claims (6)
1. a kind of bactericidal composition containing mandestrobin, it is characterised in that：The active ingredient of the bactericidal composition is
Mandestrobin and metrafenone, both mass ratioes are 1:50-50:1.
2. the bactericidal composition according to claim 1 containing mandestrobin, it is characterised in that：Active ingredient
The mass ratio of mandestrobin and metrafenone is 1:10-10:1.
3. the bactericidal composition according to claim 2 containing mandestrobin, it is characterised in that：Active ingredient
The mass ratio of mandestrobin and metrafenone is 1:5-5:1.
4. the bactericidal composition containing mandestrobin according to any one of claims 1 to 3, it is characterised in that：Group
The gross mass percentage composition of effective ingredient is 5%-80% in compound.
5. the bactericidal composition according to claim 4 containing mandestrobin, it is characterised in that：Practical application when system
Into missible oil, microemulsion, aqueous emulsion, suspending agent, dry suspending agent, microcapsule suspending agent, water dispersible granules, wettable powder or solvable grain
Agent.
6. the bactericidal composition containing mandestrobin described in claim 1 is in preventing and treating kernel approaches, pomaceous fruit and berries water
The application of powdery mildew on fruit.
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| CN201710247101.2A CN106942227A (en) | 2017-04-17 | 2017-04-17 | A kind of bactericidal composition containing mandestrobin and its application |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102834006B (en) * | 2010-03-03 | 2014-12-31 | 住友化学株式会社 | Plant disease controlling composition and method for controlling plant disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102834006B (en) * | 2010-03-03 | 2014-12-31 | 住友化学株式会社 | Plant disease controlling composition and method for controlling plant disease |
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Application publication date: 20170714 |