CN106912949A - A kind of grifola frondosus spirulina complex preparation health food and preparation method thereof - Google Patents
A kind of grifola frondosus spirulina complex preparation health food and preparation method thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/748—Cyanobacteria, i.e. blue-green bacteria or blue-green algae, e.g. spirulina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/424—Gynostemma
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
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- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of grifola frondosus spirulina complex preparation health food and preparation method thereof, primary raw material count by weight including：1 10 parts of ash tree pollen, 15 parts of spirulina powder, 1 10 parts of Chinese yam, 13 parts of American Ginseng, 25 parts of gynostemma pentaphylla, by these raw materials using milling, hot water extraction, filtering, it is concentrated under reduced pressure be dried to obtain compound dry powder, be that raw material is prepared with the composite heal-care food for adjusting blood pressure and blood lipoid with compound dry powder.Verified through pharmacodynamic experiment, this compound health-care food can significantly improve the disorders of lipid metabolism of high fat diet induction, especially, can significantly reduce T-CHOL in serum（TC）, triglyceride（TG）And LDL-C（LDL‑C）And the level of blood sugar (GT).
Description
Technical field
The invention belongs to technical field of health care food, and in particular to a kind of grifola frondosus spirulina complex preparation health food and its system
Preparation Method.
Background technology
With the improvement of living standards with the change of rhythm of life, " three high diseases " incidence of disease for being referred to as " rich man's disease " is more next
Higher, particularly more than the 50 years old common disease of the elderly's health, high fat of blood can cause blood vessel embolism；Hypertension can cause
Cerebral hemorrhage and rupture of blood vessel in brain；Hyperglycaemia can cause diabetes.The number that cardiovascular and cerebrovascular disease is died from the whole world every year is up to
15000000 people, occupy the various causes of the death the first.Therefore health products of the exploitation with lowering blood pressure are found, is treated with ancillary drug,
The concern that side effect has caused people is reduced while effective control blood sugar and blood fat.
Grifola frondosus：Grifola frondosus gray is filbert, tender crisp, the taste such as shredded chicken of meat, crisp to lure mouth like yulan, deliciousness.Ash tree
Flower nutrition very abundant, nutritive value is very high, and amino acid contained, protein is higher by one times than mushroom, with anti-cancer, anticancer and carries
The effect of immune function of human body high, has significant curative effect to diseases such as cirrhosis, diabetes, oedema, athlete's foot, difficult urinations.Often to eat
Energy body-tonifying heath, prolongs life.Spirulina：Prokaryotes, the filamentous being made up of unicellular or many cells, cylinder, in thin
Loose or close well-regulated spiral rotation shape bending, shape such as clockwork feed, so gain the name.With mitigating cancer radiation, chemotherapy
The effects such as toxicity, raising immunologic function, reduction blood fat.Chinese yam has nourishing strong, aid digestion, holds back abnormal sweating, the work(of antidiarrheal
Effect.Its optimum is taken with ganoderma lucidum collocation, with the effect for preventing and treating diabetes.American Ginseng is Araliaceae Panax renascent herb
Plant, alias American ginseng, American ginseng etc., its main component are ginsenoside, can effectively strengthen nervous centralis, are reached with all worries set aside solidifying
The effects such as god, dispelling fatigue, enhancing memory.Informal dress American Ginseng can with anti-arrhythmia, resist myocardial ischemia, it is anti-cardiac muscle oxidation,
Many effects such as reinforcing cardiac contractility ability, nourishing the stomach to improve the production of body fluid, reducing blood sugar and blood lipid.The fruit of Chinese wolfberry be rich in LBP-X, gynostemma pentaphylla also known as
Paradise grass, is Curcurbitaceae, gynostemma pentaphyllum genus herbaceous stem Climbing Plant.Arrange in pairs or groups to boil water with gynostemma pentaphylla and ganoderma lucidum or brew up, height can be treated
The diseases such as blood pressure, high fat of blood, hyperglycaemia, fatty liver.And have functions that protecting liver and detoxication, lowering blood pressure and blood fat blood sugar.
With grifola frondosus, spirulina, Chinese yam etc. is prepared for a kind of health products of compound lowering blood pressure to the present invention for raw material,
Effect is significant of the product in terms of blood fat and blood pressure possesses preferable health value, in market due to health care list product on the market
It is upper that there is wide DEVELOPMENT PROSPECT.
The content of the invention
The purpose of the present invention is main to provide a kind of proportioning simply, and prescription collocation is reasonable, with significantly regulation glucose -lipid metabolism disorder, strengthens
The composite heal-care food of the effects such as immunity of body.
To achieve these goals, the present invention is adopted the following technical scheme that：
A kind of grifola frondosus spirulina composite heal-care food for adjusting blood pressure and blood lipoid and preparation method thereof, according to " the monarch and his subjects' assistant of the traditional Chinese medical science
Make " theoretical and modern nutriology knowledge, by raw material by the proportioning through milling, hot water extraction, filtering, being concentrated under reduced pressure is dried to obtain
Compound dry powder, being prepared as raw material with compound dry powder has the trophic function of the effects such as regulation blood sugar, blood fat, blood pressure and liver protection
Property food.Its primary raw material formula number meter includes：1-10 parts of ash tree pollen, spirulina powder 1-5 parts, Chinese yam 1-10
Part, American Ginseng 1-3 parts, gynostemma pentaphylla 2-5 parts.
Described grifola frondosus spirulina complex preparation health food of a kind of regulation blood pressure and blood lipoid and preparation method thereof, it is specific to prepare
Method is as follows：
A. Grifola Frondosa sporophore is worn into fine powder stand-by, ash tree pollen is taken by raw material proportioning, spirulina powder, Chinese yam, American Ginseng is twisted
Stock is blue, mixing；
B. the 20-50 times of water of weight is added in the mixed material of step A, 1-3h is extracted in 80-100 DEG C of extractor, passed through
Extract solution and filter residue are filtered to obtain, filter residue is repeated to extract 1-3 times, merge extract solution；
C. the extract solution after merging is placed in filter and is filtered, concentrated under the conditions of 60-100 DEG C, 0.05-0.095MPa,
Concentrate, through dry composite powder；
D. composite powder is prepared into oral liquid, capsule, tablet, electuary, solid beverage, the nutrition of different dosage forms, feature food
Product.
Composition principle of the invention is elaborated：
Grifola frondosus：Grifola frondosus gray is filbert, tender crisp, the taste such as shredded chicken of meat, crisp to lure mouth like yulan, deliciousness.Grifola frondosus are sought
Very abundant is supported, nutritive value is very high, and amino acid contained, protein is higher by one times than mushroom, with anti-cancer, anticancer and raising people
The effect of body immunity function, has significant curative effect to diseases such as cirrhosis, diabetes, oedema, athlete's foot, difficult urinations.Often to eat can be mended
Body is healthy and strong, and is prolonged life.
Spirulina：Prokaryotes, the filamentous being made up of unicellular or many cells, cylinder, in loose or closely have
The spiral rotation shape bending of rule, shape such as clockwork feed, so gain the name.With the toxicity for mitigating cancer radiation, chemotherapy, improve
The effects such as immunologic function, reduction blood fat.
Chinese yam：Chinese yam has and nourishes strong, aid digestion, the effect of hold back abnormal sweating, antidiarrheal.Its optimum is arranged in pairs or groups with ganoderma lucidum and is taken
With with the effect for preventing and treating diabetes.
American Ginseng：American Ginseng is Araliaceae Panax herbs perennial vegetation, alias American ginseng, American ginseng etc., its mainly into
Be divided into ginsenoside, can effectively strengthen nervous centralis, reach it is with all worries set aside with fixed attention, the effect such as dispelling fatigue, enhancing memory.Informal dress
American Ginseng can with anti-arrhythmia, resist myocardial ischemia, it is anti-cardiac muscle oxidation, reinforcing cardiac contractility ability, nourishing the stomach to improve the production of body fluid, hypoglycemic blood
Many effects such as fat.
Gynostemma pentaphylla：Gynostemma pentaphylla, also known as paradise grass, is Curcurbitaceae, gynostemma pentaphyllum genus herbaceous stem Climbing Plant.With gynostemma pentaphylla and ganoderma lucidum
Collocation is to boil water or brews up, and can treat the diseases such as hypertension, high fat of blood, hyperglycaemia, fatty liver.And have protecting liver and detoxication, auxiliary drop blood
Effect of piarhemia sugar.
Usefulness of the present invention：
1. all to use natural materials be raw material to the present invention, not only can direct auxiliary hyperglycemic, and can be to a certain extent
Auxiliary reducing blood lipid.
2. compatibility science of the present invention, safe and reliable, is suitable to industrialized production.
3. the present invention is a kind of grifola frondosus spirulina complex preparation health products, and effect of the product in terms of blood pressure and blood lipoid is adjusted shows
Write due to health care list product on the market, possess preferable health value, commercially with wide DEVELOPMENT PROSPECT.
Brief description of the drawings
Fig. 1 is that influence of the grifola frondosus spirulina complex preparation health products to the triglycerides of high fat diet inducing obesity rat is made
With；
Fig. 2 is that influence of the grifola frondosus spirulina complex preparation health products to the serum total cholesterol of high fat diet inducing obesity rat is made
With；
Fig. 3 is that influence of the grifola frondosus spirulina complex preparation health products to the HDL of high fat diet inducing obesity rat is made
With；
Fig. 4 is that influence of the grifola frondosus spirulina complex preparation health products to the low-density lipoprotein of high fat diet inducing obesity rat is made
With.
Specific embodiment
In order that content of the present invention easily facilitates understanding, with reference to specific embodiment to of the present invention
Technical scheme is described further, but the present invention is not limited only to this.
Case study on implementation one:
A kind of the step of preparation method of grifola frondosus spirulina complex preparation health food is：
A. 5 parts of ash tree pollen, 2 parts of spirulina powder, 5 parts of Chinese yam, 1 part of American Ginseng, the raw material proportioning that 2 parts of gynostemma pentaphylla are pressed（By weight
Part meter）, take ash tree pollen, spirulina powder, Chinese yam, American Ginseng, gynostemma pentaphylla, mixing；
B. 30 times of water of weight are added in the mixed material of step A, 1h is extracted in 100 DEG C of extractors, must extracted through filtering
Liquid and filter residue, filter residue is repeated to extract 2 times, merges extract solution；
C. the extract solution after merging is placed in filter and is filtered, concentrated under the conditions of 90 DEG C, 0.05-0.095MPa, obtain dense
Contracting liquid, through dry composite powder；
D., composite powder is prepared into the health-caring capsule of regulation blood pressure and blood lipoid.
Case study on implementation two:
A kind of the step of preparation method of grifola frondosus spirulina complex preparation health food is：
A. 10 parts of ash tree pollen, 5 parts of spirulina powder, 10 parts of Chinese yam, 3 parts of American Ginseng, the raw material proportioning that 5 parts of gynostemma pentaphylla are pressed（By weight
Amount part meter）, take ash tree pollen, spirulina powder, Chinese yam, American Ginseng, gynostemma pentaphylla, mixing；
B. 40 times of water of weight are added in the mixed material of step A, 2h is extracted in 90 DEG C of extractors, through filtering to obtain extract solution
And filter residue；
C. extract solution is placed in filter and is filtered, 10 times are concentrated under the conditions of 85 DEG C, 0.05-0.095MPa, must concentrated
Liquid；
D. concentrate is made the compound of auxiliary hyperglycemic blood fat by weight the ppm of Aspartame 500 and malic acid 0.5% is added
Health care oral liquid.
E, deployed oral liquid with saline bottle is filling, locking closure, become through water dip sterilization and after the assay was approved product while hot
Product.
Case study on implementation three:
A kind of the step of preparation method of grifola frondosus spirulina complex preparation health food is：
A. 8 parts of ash tree pollen, 3 parts of spirulina powder, 8 parts of Chinese yam, 2 parts of American Ginseng, the raw material proportioning that 3 parts of gynostemma pentaphylla are pressed（By weight
Part meter）, take ash tree pollen, spirulina powder, Chinese yam, American Ginseng, gynostemma pentaphylla, mixing；
B. 20 times of water of weight are added in the mixed material of step A, 1h is extracted in 95 DEG C of extractors, through filtering to obtain extract solution
And filter residue, filter residue is repeated to extract 3 times, merge extract solution；
C. the extract solution after merging is placed in filter and is filtered, 10 times are concentrated under the conditions of 95 DEG C, 0.05-0.095MPa,
Obtain concentrate；
D. concentrate is made the compound of auxiliary hyperglycemic blood fat by weight the ppm of Aspartame 300 and malic acid 0.3% is added
Health care oral liquid.
E, deployed oral liquid with saline bottle is filling, locking closure, become through water dip sterilization and after the assay was approved product while hot
Product.
Zoopery
Experimental technique：
To meet modern humans' life style（High fat diet custom based on animal food）Angle set out, it is high using sugar high
Fat feed（Basal feed 67%, lard 10%, sucrose 20%, cholesterol 3%）Set up the glucose -lipid metabolism disorder mould of high fat diet induction
Type, carries out the Dietary frequency feeding trial of 2 months by a definite date.Experiment sets 6 groups, including Normal group（NFD）, fat control group high
（HFD）With compound group（GFSP）.After giving given the test agent 60 days, fasting Wistar rats are anaesthetized, in clean bench, first
Blood is taken by the apex of the heart, it is solid by total courage in automatic biochemistry analyzer and kit assay serum by blood collection in heparin tube
Alcohol (TC), triglyceride (TG), HDL-C (HDL-C), LDL-C (LDL-C) and blood sugar
（GT）Etc. level.Experimental result as Figure 1-4, knowable to experimental result, for serum total cholesterol, model group with it is normal
Group is compared, and as a result has pole conspicuousness to raise（P<0.01）, compound group has the reduction of pole conspicuousness compared with model group, as a result（P<
0.01）, for triglycerides, model group compares with normal group, the rising for as a result having pole conspicuousness（P<0.01）, compound group with
Model group compares, and has pole conspicuousness reduction（P<0.01）.For HDL, model group compares with normal group, as a result
Having conspicuousness reduces（P<0.05）, compound group compares with model group, has conspicuousness to raise（P<0.05）, with regard to low-density lipoprotein
Speech, model group compares with normal group, as a result has pole conspicuousness to raise（P<0.01）, compound group compares with model group, there is extremely notable
Property reduce（P<0.01）.
Annex：Influence of the complex health care product to high fat diet inducing obesity rat blood index
Note：" NFD " refers to blank group, and gavage physiological saline feeds chow diet；
" HDF " refers to model group, gavage physiological saline；Feed high lipid food；
" GFSP " refers to the experimental group of compound gavage, feeds high lipid food；
The foregoing is only presently preferred embodiments of the present invention, all impartial changes done according to scope of the present invention patent with repair
Decorations, should all belong to covering scope of the invention.
Claims (3)
1. a kind of grifola frondosus spirulina complex preparation health food, it is characterised in that：The primary raw material of the compound health-care food is by weight
Amount number meter includes：1-10 parts, spirulina powder 1-5 parts, Chinese yam 1-10 parts, American Ginseng 1-3 parts, gynostemma pentaphylla 2-5 parts of ash tree pollen.
2. a kind of preparation method of grifola frondosus spirulina complex preparation health food as claimed in claim 1, it is characterised in that：Will
Raw material by proportioning through milling, hot water extraction, filtering, be concentrated under reduced pressure be dried to obtain compound dry powder, with compound dry powder as raw material
Prepare the nutrient functional foods with regulation blood pressure and blood lipoid effect.
3. the preparation method of a kind of grifola frondosus spirulina complex preparation health food according to claims 2, it is characterised in that：
Specific preparation method is as follows：
A. Grifola Frondosa sporophore is worn into fine powder stand-by, ash tree pollen is taken by raw material proportioning, spirulina powder, Chinese yam, American Ginseng is twisted
Stock is blue, mixing；
B. the 20-50 times of water of weight is added in the mixed material of step A, 1-3h is extracted in 80-100 DEG C of extractor, passed through
Extract solution and filter residue are filtered to obtain, filter residue is repeated to extract 1-3 times, merge extract solution；
C. the extract solution after merging is placed in filter and is filtered, concentrated under the conditions of 60-100 DEG C, 0.05-0.095MPa,
Concentrate, through dry composite powder；
D. composite powder is prepared into oral liquid, capsule, tablet, electuary, solid beverage, the nutrition of different dosage forms, feature food
Product.
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