CN105250729A - Dendrobium officinale electuary and preparing method thereof - Google Patents
Dendrobium officinale electuary and preparing method thereof Download PDFInfo
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Abstract
The invention relates to a dendrobium officinale electuary. The dendrobium officinale electuary is characterized by being prepared from, by weight, 40-250 parts of dendrobium officinale, 30-170 parts of radix ophiopogonis, 3-17 parts of liquorice, 7-40 parts of American ginseng extract, 2-12 parts of lucid ganoderma extract, 50-300 parts of lactose and 1-6 parts of stevioside, and lactose and stevioside are auxiliary materials. Dendrobium officinale, radix ophiopogonis and liquorice are extracted firstly with a specific method, so that crude polysaccharide yield and extraction ratio are high under the corresponding extraction condition. Due to the fact that the specific kinds of medicinal materials are adopted to be matched, compared with an electuary which does not contain radix ophiopogonis and/or liquorice, the optimum efficacy of the medicinal materials adopted in the formula is realized through synergism between the medicinal materials and main functional components.
Description
[technical field]
The present invention relates to biological and new medical technology Chinese herbal medicine field of deep, be specifically related to the application of electuary containing Herba Dendrobii and preparation method thereof and raising immunity.
[background technology]
Modern society, the pathogenetic underlying causes of a lot of disease is that hypoimmunity or immunity are unsound.Human immune system is perfect, then body is harmonious, healthy; Otherwise body is impaired, show as easy infection or easy sick state." in healthy energy deposits, heresy can not be done, gathering of heresy, and its gas must be empty ", healthy energy just refers to the resistance against diseases of human body, namely immunity, and positive QI-insufficiency shows as deficient syndrome, notices that protection immune system is without prejudice most important.
Herba Dendrobii (DendrobiumofficinaleKimuraetMigo) is also referred to as Herba Dendrobii, and it is the dry stem of orchid, has the effect of " nourishing YIN and clearing away heat; reinforcing stomach reg fluid ", the title have " help Herba mesonae chinensis " among the people, as far back as Qin Han dynasty, Shennong's Herbal just records Herba Dendrobii " main damaging the spleen and stomach; eliminating impediment; the therapeutic method to keep the adverse QI flowing downwards, tonifying five ZANG-organs asthenia weakness and emaciation, reinforcing YIN-essence; take thick the intestines and stomach for a long time ", and it is first of " China's nine large Herba mesonae chinensis " to become book " Taoist Scriptures " honor before more than 1,000 years.Li Shizhen (1518-1593 A.D.) evaluates Herba Dendrobii " reinforcing YIN-essence benefit is smart, thick the intestines and stomach, never sufficient in benefit, flat gastric qi, longue meat, and Fructus Alpiniae Oxyphyllae, except frightened, made light of one's life by commiting suicide and prolonged life " in Compendium of Material Medica; Among the peoplely be called help Herba mesonae chinensis, international medicinal plants circle is called " medicine circle giant panda ".Due to YIN nourishing benefiting action and the health-care effect widely of Herba Dendrobii brilliance, be regarded as the treasure in Herba Dendrobii always, 2010 version " Chinese Pharmacopoeia " Herba Dendrobii is single-row and be different from other Herba Dendrobiis.
Having another name called dwarf lilyturf, book band grass, Radix Ophiopogonis, Radix Ophiopogonis Radix Ophiopogonis (Ophiopogonjaponicus), is Liliaceae Ophiopogon perennial evergreen herbaceous plant.Fibrous root is more sturdy, and the top of root or middle part are often expanded becomes fusiform meat fritter, is used as medicine with tuber.The compositions such as steroidal saponin, polysaccharide, flavonoid, aminoacid, trace element are mainly comprised in Radix Ophiopogonis, the research of Radix Ophiopogonis polysaccharide pharmacological action in recent years shows, Radix Ophiopogonis polysaccharide has multiple drug effect, mainly concentrates on immunocompetence, resists myocardial ischemia, the aspect such as blood sugar lowering, anoxia enduring, antiallergic.
Radix Panacis Quinquefolii is the dry root of Araliaceae Radix Panacis Quinquefolii (PanaxquinguefoliumL.), is one of famous and precious supplementing QI and nourishing YIN medicine.There is invigorating qi and benefiting blood, lung heat clearing kidney, cool heart spleen, clear asthenic fire, promoting the production of body fluid to quench thirst, nourishing YIN brought down a fever, adjust tonifying five ZANG-organs, effect such as relieving restlessness, controlling nocturnal emission with astringent drugs of calming the nerves.Radix Panacis Quinquefolii main component comprises saponin, protein, aminoacid, nucleic acid, peptide class, sterols, flavonoid, polysaccharide, starch, volatile oil, vitamin, pectic substance, fatty acid, mineral and trace element, pharmacological research shows, Radix Panacis Quinquefolii contains multiple physiologically active ingredient, wherein ginsenoside and polysaccharide are effective ingredient main in Radix Panacis Quinquefolii, are also the most significant materials of physiologically active.Radix Panacis Quinquefolii has enhancing immunity, anticancer, resisting fatigue, anti-hypoxia, anti-ageing several functions of waiting for a long time.
Ganoderma (GanodermaLucidumKarst), profile is umbrella, cap kidney shape, semicircle or subcircular, is the sporophore of On Polyporaceae Ganoderma.There is effect of invigorating QI and tranquilization, relieving cough and asthma, for dizzy sleeplessness, shortness of breath and palpitation, asthenia cough with asthma.The medicinal history having more than 2000 year in China of Ganoderma, is considered as the magical treasure of strengthening by means of tonics, strengthening the body resistance by successive dynasties medicine man.Ganoderma is containing polysaccharide, ucleosides, furans, sterols, alkaloid, triterpenes, oils, several amino acids and protein-based, enzyme, organic germanium and various trace elements etc., polysaccharide is its main active, has effects such as improving immunoregulation capability, Tumor suppression, resisting fatigue, suppression oxygen-derived free radicals, protecting liver and detoxication, raising oxygen deficit tolerance, calmness and heart tonifying.
Radix Glycyrrhizae (GlycyrrhizauralensisFisch) is called: state is old, Herba Hedyotis cantonensis, Glycyrrhiza uralensis Fisch., sweet root.Pulse family, Glycyrrhiza perennial herb, root and root stock sturdy, be a kind of tonification Chinese herbal medicine.To the good a kind of medicine of human body, medicinal part is root and rhizome.Containing various active composition in Radix Glycyrrhizae, mainly triterpenes, flavonoid, polysaccharide, also have Coumarins, amino acids, alkaloids, volatile oil and various trace elements etc. in addition, pharmacological research mainly concentrates on the compounds such as polysaccharide, glycyrrhizic acid, enoxolone, total flavones, single flavone, and polysaccharide works the main active strengthening immunologic function in Radix Glycyrrhizae.
According to the result of state food pharmaceuticals administration general bureau health food data base querying, the health food that Herba Dendrobii/Herba Dendrobii is relevant has 78 kinds, wherein the health product raw material of more than 78% is Herba Dendrobii or Herba Dendrobii and Radix Panacis Quinquefolii, what the basis of this two tastes medicine was added Ganoderma or Sporoderm-broken Ganoderma Lucidum Spore powder is 15%, at Herba Dendrobii be add Radix Ophiopogonis in the health product of primary raw material only have 8%, and by Herba Dendrobii, Radix Ophiopogonis, Radix Panacis Quinquefolii extract, the health product of Ganoderma extract and the comprehensive compatibility of Radix Glycyrrhizae do not inquire in state food pharmaceuticals administration general bureau national OTC.
[summary of the invention]
The object of this invention is to provide a kind of with Herba Dendrobii, Radix Ophiopogonis, Radix Panacis Quinquefolii extract, Ganoderma extract and Radix Glycyrrhizae for raw material, there is the health food of enhancing immunity.By synergism, reach effect of enhancing immunity, improve the comprehensive adjustment ability of human body.
The object of the invention is to have come by following technical solution:
A kind of Herba Dendrobii electuary, it is characterized in that, described electuary comprises 40-250 part Herba Dendrobii by weight, 30-170 part Radix Ophiopogonis, 3-17 part Radix Glycyrrhizae, 7-40 part Radix Panacis Quinquefolii extract, 2-12 part Ganoderma extract and as 50 ~ 300 parts of lactose of adjuvant and 1 ~ 6 part of stevioside.
Preferably, Herba Dendrobii is 60-220 weight portion; Be more preferably 100-150 weight portion.
Preferably, Radix Ophiopogonis is 50-140 weight portion; Be more preferably 80-120 weight portion.
Preferably, Radix Panacis Quinquefolii extract is 10-30 weight portion; Be more preferably 12-25 weight portion.
Preferably, Radix Glycyrrhizae is 5-15 weight portion, is more preferably 6-12 weight portion.
Further, the present invention also provides the preparation method of above-mentioned Herba Dendrobii electuary, it is characterized in that, described preparation method comprises the steps:
(1) raw material pre-treatment
(1) broken: the Herba Dendrobii of formula ratio is added crusher in crushing, for subsequent use;
(2) extract: Herba Dendrobii and Radix Ophiopogonis, Radix Glycyrrhizae are mixed in extraction pot, add the drinking water of 8-40 times amount, soak 1h, be heated to 90 DEG C, extract 1-3h, feed liquid is filtered, and extracts 3 times, merges feed liquid;
(3) concentrated: feed liquid vacuum to be drawn in two effect concentrators, at 60 ~ 80 DEG C, vacuum be concentrate under-0.06 ~-0.08MPa, is concentrated into relative density 1.12 ~ 1.14, obtains concentrated extract;
(2) sieve
100 mesh sieves crossed by lactose;
(3) with slurry: the deal being 15:1 by solid-to-liquid ratio gets purified water heated and boiled, add Radix Panacis Quinquefolii extract, Ganoderma extract, stevioside, limit edged is uniformly mixed, mixing 10min, add concentrated extract again, heat while stirring, boil insulation 10min, 200 orders filter, obtain serosity;
Described Radix Panacis Quinquefolii extract is that to choose American ginseng root be raw material, and cut off and pulverize rear ethanol extraction, then filter to get filtrate, by filtrate after concentrating under reduced pressure, namely spraying dry obtains Radix Panacis Quinquefolii extract.
Ganoderma extract is raw material with Ganoderma sporophore, and add edible ethanol after pulverizing and sieving and extract, filtering and concentrating obtains alcohol-extracted extract, and alcohol-extracted extract concentrates through water extraction again, and centrifugal, spraying dry, namely obtains Ganoderma extract after sieving;
(4) boiling granulating
Lactose after sieving is added in fluid bed granulator material container, setting temperature of charge 50 ~ 60 DEG C, dry 20 ~ 30min, the serosity prepared is sprayed in fluid bed granulator and granulates, granulate and terminate, be dried to moisture and be less than 3%, temperature of charge is down to less than 40 DEG C, rewinding;
(5) granulate: granule is crossed 14 orders and 65 mesh sieve granulate.
Preferably, in the extraction step (2) of step (one), Herba Dendrobii and Radix Ophiopogonis, Radix Glycyrrhizae are mixed in extraction pot, add the drinking water of 14 or 16 times amount, soak 1h, be heated to 90 DEG C, extract 1.5-2.0h, feed liquid is filtered, and extracts 3 times, merges feed liquid.
Finally carry out collecting granules, weigh, identify, and carry out subpackage by technological requirement, and the conventional steps such as packaging, inspection warehouse-in.
Further, the invention provides Herba Dendrobii electuary for the preparation of the purposes improving immunity medicine.
Usefulness of the present invention is:
The bioactive substances such as the aminoacid containing polysaccharide, polyphenols, dendrobine, trace element and needed by human in Herba Dendrobii are one of desirable material of natural health tea.Dendrobium officinale polysaccharide can offset the violent decline adding caused peripheral leukocytes of Immunosuppressant Cyclophosphamide under experiment condition forcefully, eliminate its destructive side effect, migration inhibitory factor can also be produced by Promote immunity systemic lymphoid cell, effectively offsetting the side effect adding caused lifting mobile inhibition index of cyclophosphamide, is a kind of of great value Chinese medicine para-immunity reinforcing agent.
The present invention adopts specific method first to extract Herba Dendrobii, Radix Ophiopogonis and Radix Glycyrrhizae, under corresponding extraction conditions, better result can be obtained in crude polysaccharides yield, paste-forming rate, select this several specific medical material matched simultaneously, compare and lack Radix Ophiopogonis and/or Radix Glycyrrhizae, can enhancing immunity greatly, each medicine and main composition synergism thereof, play the optimum medicine efficacy of formulation of drug.
[detailed description of the invention]
Below in conjunction with embodiment, summary of the invention is described further:
Embodiment one:
A kind of ferrum dry measure used in former times electuary with enhancing immunity of the present embodiment, its effective ingredient forms primarily of the raw material of following quality:
150 parts of Herba Dendrobii, 120 parts of Radix Ophiopogonis, 25 parts of Radix Panacis Quinquefolii extracts, 8 parts of Ganoderma extracts, 12 parts of Radix Glycyrrhizaes, 250 parts of lactose and 3 parts of stevioside.
Above-mentioned ferrum dry measure used in former times electuary preparation method, comprises the following steps:
(1) broken: the Herba Dendrobii of formula ratio is added crusher in crushing, for subsequent use;
(2) extract: Herba Dendrobii and Radix Ophiopogonis, Radix Glycyrrhizae are mixed in extraction pot, add the drinking water of 8-40 times amount, soak 1h, be heated to 90 DEG C, extract 1-3h, feed liquid is filtered, and extracts 3 times, merges feed liquid; To select in leaching process with Extracting temperature, extraction time, solid-liquid ratio, extraction time, for investigation factor, to carry out orthogonal experiment, draw polyoses content and the high experimental program of paste-forming rate, specific experiment result as shown in Table 1 and Table 2.
Table 1
Table 2
Amount/medical material amount × 100% of crude polysaccharides in crude polysaccharides yield=extracting solution
Dry cream amount/medical material amount × 100% in paste-forming rate=extracting solution
Comprehensive grading=crude polysaccharides yield/maximum crude polysaccharides yield × 0.6 × 100+ paste-forming rate/maximum paste-forming rate × 0.4 × 100;
As can be seen here, the extraction conditions of above-mentioned numbering 4 is most preferred, and namely Extracting temperature is 90 DEG C, extraction time is 1.5-2.0 hour, solid-liquid ratio is 1:14 or 1:16, extraction time is 3 times.
(3) concentrated: feed liquid vacuum to be drawn in two effect concentrators, at 60 ~ 80 DEG C, vacuum be concentrate under-0.06 ~-0.08MPa, is concentrated into relative density 1.12 ~ 1.14, obtains concentrated extract.
(2) sieve
100 mesh sieves crossed by lactose;
(3) with slurry: the deal being 15:1 by solid-to-liquid ratio gets appropriate purified water heated and boiled, add Radix Panacis Quinquefolii extract, Ganoderma extract, stevioside, limit edged is uniformly mixed, mixing 10min, add concentrated clear paste again, heat while stirring, boil insulation 10min, 200 orders filter, for subsequent use;
Described Radix Panacis Quinquefolii extract is that to choose American ginseng root be raw material, and cut off and pulverize rear ethanol extraction, then filter to get filtrate, by filtrate after concentrating under reduced pressure, namely spraying dry obtains Radix Panacis Quinquefolii extract.
Ganoderma extract is raw material with Ganoderma sporophore, and add edible ethanol after pulverizing and sieving and extract, filtering and concentrating obtains alcohol-extracted extract, and alcohol-extracted extract concentrates through water extraction again, and centrifugal, spraying dry, namely obtains Ganoderma extract after sieving.
(4) boiling granulating
Lactose after sieving is added in fluid bed granulator material container, starting device, setting temperature of charge 50 ~ 60 DEG C, dry 20 ~ 30min, regulates atomizing pressure, peristaltic pump frequency and blower fan frequency according to material boiling situation, is sprayed in fluid bed granulator by the serosity prepared and granulate, granulate and terminate, be dried to moisture and be less than 3%, temperature of charge is down to less than 40 DEG C, rewinding;
(5) granulate: granule is crossed 14 orders and 65 mesh sieve granulate, collecting granules, weighs, identifies;
(6) subpackage: carry out subpackage by technological requirement;
(7) pack: with the granulate date for the date of manufacture, formulate lot number, labeling, packaging simultaneously;
(8) inspection warehouse-in: by standard test after finished product sampling, warehousing after passing.
Comparative examples A: except wherein not containing except Radix Ophiopogonis, all the other are all with embodiment one;
Comparative examples B: except wherein not containing except Radix Glycyrrhizae, all the other are all with embodiment one;
Comparative examples C: except wherein not containing except Radix Ophiopogonis and Radix Glycyrrhizae, all the other are all with embodiment one.
Embodiment two: toxicological study is tested
One, experiment purpose:
By contrast experiment, the safety of the ferrum dry measure used in former times electuary prepared by Evaluation operation example 1.
Two, laboratory sample and character:
Sample is light brown yellow granule, for subsequent use.
Three, experimental technique:
3.1 acute oral toxicity tests:
3.1.1 laboratory animal: SD rat, body weight 180-200g; ICR mice, body weight 18 ~ 20g.
3.1.2 dosage and medication: experiment adopts maximum tolerated dose method, before contamination, overnight fasting, not water restriction.If 20.0g/kg body weight dosage group.20 animals, each class of male and female, adopts per os gavage mode.Embodiment 1 gained granule adds deionized water, is made into 0.5mg/mL, by 20mL/kg body weight, and gavage twice, every minor tick 4h.
3.2Ames tests: Salmonella typhimurium back mutation is tested.
3.2.1 test adopts dull and stereotyped incorporation methods: select 5000 μ g/ wares to be maximum dose level, embodiment 1 gained granule adds deionized water, is made into 50000 μ g/mL, and is diluted to 10000,2000,400 and 80 μ g/mL successively, for test after moist heat sterilization.Matched group is set.
3.3 mouse marrow cell micro nuclear tests:
3.3.1 laboratory animal ICR mice, body weight 25-30g.
3.3.2 dosage and medication: establish 2.5,5.0 and 10.0g/kg body weight three dosage groups, and set matched group.Often organize 10 mices, female, hero half and half.Interval 24h is adopted to give sample.After last administration, 6h puts to death mice, and get its bone marrow of sternum film-making, methanol is fixed, and Gimsa dyes.
3.4 mouse inbred strain:
3.4.1 laboratory animal ICR mice, body weight 30 ~ 35g.
3.4.2 dosage and medication: establish 2.5,5.0 and 10.0g/kg body weight three dosage groups, and set matched group.Often organize 6 male mices, gavage, continuous 5 days.Within 35th day, put to death mice, get epididymis, microscopy.Record rate of teratosperm.
Four, experimental result
Ferrum dry measure used in former times electuary Toxicological evaluation result of the test prepared by embodiment 1: large and small Mus acute oral maximum tolerated dose bisexuality is not and is greater than 20.0g/kg, belongs to nontoxic; Salmonella reversion test, mouse marrow cell micro nuclear test and mouse inbred strain result are feminine gender, do not show mutagenicity.
Embodiment three: enhancing immunity function test
One, experiment purpose:
By contrast experiment, the enhancing functional trial of comparative examples A, B, C compared by the ferrum dry measure used in former times electuary prepared by Evaluation operation example 1.
Two, laboratory sample and character:
Adopt sample obtained by above-described embodiment one, comparative examples A, sample obtained by B, C.
Three, experimental technique:
3.1 laboratory animals: ICR mice, female, body weight 20 ± 2g.
3.2 dose design: three dosage groups and negative control group (deionized water) are established in experiment.Low middle high three dosage are respectively 0.5,1.0,3.0g/kg body weight, be equivalent to 5,10 and 30 times of people's recommended amounts, gavage gives sample.Sample obtained by comparative examples A, B, C dosage used is middle dosage 1.0g/kg.
3.3 experimental techniques:
3.3.1 conversion test;
3.3.2 sheep red blood cell (SRBC) (SRBC) inducing mouse DTH (the sufficient sole of the foot thickens method);
3.3.3 mice hemolysin test;
3.3.4 antibody-producting cell detects (Jerne improves slide method);
3.3.5 Turnover of Mouse Peritoneal Macrophages engulfs chicken red blood cell test;
3.3.6 mice carbonic clearance is tested;
3.3.7NK cytoactive detection;
3.3.8 internal organs/body weight ratio.
Four, experimental result
Basic, normal, high three dosage groups are established in this experiment, and be equivalent to 5,10,30 times of the actual intake of people respectively, establish negative control group (deionized water) simultaneously, continuous 29-32 days per os gives the ferrum dry measure used in former times electuary prepared by embodiment 1 of various dose.Experimental result shows: as table 3, table 4 and table 5, and the ferrum dry measure used in former times electuary three dosage group mouse lymphocyte multiplication capacity optical density difference prepared by embodiment 1 all obviously raises, and about middle dosage group mice, sufficient sole of the foot portion obviously raises with 0 hour thickness difference for 24 hours; Middle and high dosage group mice hemolysis plaque number all obviously raises; The phagocytic percentage that high dose group Turnover of Mouse Peritoneal Macrophages engulfs chicken red blood cell obviously raises, and the phagocytic index that middle and high dosage group Turnover of Mouse Peritoneal Macrophages engulfs chicken red blood cell all obviously raises, and difference all has significance.Under equal experiment condition, the sample obtained by comparative examples A, B of Isodose, mouse lymphocyte multiplication capacity optical density difference does not show rising, sufficient sole of the foot portion 24 hours and 0 hour thickness difference ferrum dry measure used in former times electuary experimental group lower than middle dosage group about mice; The same low dose group of mice hemolysis plaque number rising index, the Turnover of Mouse Peritoneal Macrophages phagocytic percentage of engulfing chicken red blood cell lower than same dosage group embodiment 1 prepared by ferrum dry measure used in former times electuary.Sample obtained by comparative examples C, all experiment indexes are all lower than the low dose group prepared by embodiment.
Table 3
Table 4
Table 5
It can thus be appreciated that the ferrum dry measure used in former times electuary containing special component prepared by embodiment one is compared and is not increased significantly in enhancing immunity containing Radix Ophiopogonis, the Comparative Examples A of Radix Glycyrrhizae, B and C.
Above-described embodiment is only for illustrating technical conceive and the feature of this explanation; its object is to person skilled in the art can be understood content of the present invention and implement according to this; can not limit the scope of the invention with this; all equivalences done according to spirit of the present invention change or modify, and all should contain the row of protection scope of the present invention.
Claims (9)
1. a Herba Dendrobii electuary, is characterized in that described electuary comprises 40-250 part Herba Dendrobii by weight, 30-170 part Radix Ophiopogonis, 3-17 part Radix Glycyrrhizae, 7-40 part Radix Panacis Quinquefolii extract, 2-12 part Ganoderma extract and as 50 ~ 300 parts of lactose of adjuvant and 1 ~ 6 part of stevioside.
2. Herba Dendrobii electuary according to claim 1, is characterized in that, Herba Dendrobii is 60-220 weight portion.
3. Herba Dendrobii electuary according to claim 2, is characterized in that, Herba Dendrobii is 100-150 weight portion.
4. Herba Dendrobii electuary according to claim 1, is characterized in that, Radix Ophiopogonis is 80-120 weight portion.
5. Herba Dendrobii electuary according to claim 1, is characterized in that, Radix Panacis Quinquefolii extract is 12-25 weight portion.
6. Herba Dendrobii electuary according to claim 1, is characterized in that, Radix Glycyrrhizae is 6-12 weight portion.
7., according to the preparation method of the arbitrary described Herba Dendrobii electuary of claim 1 to 6, it is characterized in that, described preparation method comprises the steps:
(1) raw material pre-treatment
(1) broken: the Herba Dendrobii of formula ratio is added crusher in crushing, for subsequent use;
(2) extract: Herba Dendrobii and Radix Ophiopogonis, Radix Glycyrrhizae are mixed in extraction pot, add the drinking water of 8-40 times amount, soak 1h, be heated to 90 DEG C, extract 1-3h, feed liquid is filtered, and extracts 3 times, merges feed liquid;
(3) concentrated: feed liquid vacuum to be drawn in two effect concentrators, at 60 ~ 80 DEG C, vacuum be concentrate under-0.06 ~-0.08MPa, is concentrated into relative density 1.12 ~ 1.14, obtains concentrated extract;
(2) sieve
100 mesh sieves crossed by lactose;
(3) with slurry: the deal being 15:1 by solid-to-liquid ratio gets purified water heated and boiled, add Radix Panacis Quinquefolii extract, Ganoderma extract, stevioside, limit edged is uniformly mixed, mixing 10min, add concentrated extract again, heat while stirring, boil insulation 10min, 200 orders filter, obtain serosity;
Described Radix Panacis Quinquefolii extract is that to choose American ginseng root be raw material, and cut off and pulverize rear ethanol extraction, then filter to get filtrate, by filtrate after concentrating under reduced pressure, namely spraying dry obtains Radix Panacis Quinquefolii extract;
Ganoderma extract is raw material with Ganoderma sporophore, and add edible ethanol after pulverizing and sieving and extract, filtering and concentrating obtains alcohol-extracted extract, and alcohol-extracted extract concentrates through water extraction again, and centrifugal, spraying dry, namely obtains Ganoderma extract after sieving;
(4) boiling granulating
Lactose after sieving is added in fluid bed granulator material container, setting temperature of charge 50 ~ 60 DEG C, dry 20 ~ 30min, the serosity prepared is sprayed in fluid bed granulator and granulates, granulate and terminate, be dried to moisture and be less than 3%, temperature of charge is down to less than 40 DEG C, rewinding;
(5) granulate: granule is crossed 14 orders and 65 mesh sieve granulate.
8. preparation method according to claim 7, it is characterized in that, in the extraction step (2) of step (one), Herba Dendrobii and Radix Ophiopogonis, Radix Glycyrrhizae are mixed in extraction pot, add the drinking water of 14 or 16 times amount, soak 1h, be heated to 90 DEG C, extract 1.5-2.0h, feed liquid is filtered, extract 3 times, merge feed liquid.
9. according to the purposes of the arbitrary described Herba Dendrobii electuary of claim 1 to 8 for the preparation of raising immunity medicine.
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| CN112021566A (en) * | 2020-08-24 | 2020-12-04 | 浙江红石梁集团天台山乌药有限公司 | Dendrobium officinale, American ginseng and radix ophiopogonis granules |
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| 郭建生等: "《保健品与亚健康》", 31 May 2009, 中国中医药出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105707889A (en) * | 2016-03-10 | 2016-06-29 | 浙江万寿康药业有限公司 | Dendrobium officinale oral liquid and preparing technology thereof |
| CN112021566A (en) * | 2020-08-24 | 2020-12-04 | 浙江红石梁集团天台山乌药有限公司 | Dendrobium officinale, American ginseng and radix ophiopogonis granules |
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